insulin receptor-like 1 protein

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTS-----EYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRN--FCLEFCPN------NCP----RGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDH-YAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYC----GRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPV-------------VIDNLLPAKRYAFYAEAIRS---RVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNK--NQILINIDKDDTIMQFLDEYITKSFIKQN-------EIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTR---------WVSSNPDYW--------IIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +VC  +DIR   + +  L NC+VIEG L I ++  T      + SFP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  +GL NL  +  G VRI+ N  LCY+ TI+W+ I+        ++N  +   C + CP       NCP     G+ +++ CW H+ CQ VC   C  +   C       CCH ECLG C    D   CV+C+N   +GRCV+ C   +Y +++ RC++ S C +L  +     R+  H Y I ++ C+ +C  G   N     C  C   C K  C    G   I S+    E  GC  I    I    GG++L+  L      +  I   L+I +S ++ SL F R LR+I+G +    N            F   DN+NL +++D     ++ N+TI +G + F+ N KLC  +I   +     TK +  + D  I   +NGD A C++E L    +  S     ++     P    ++     LF  +   +NV++++  ++C   +W  V+  I  P+             ++  L P  +YA + + + +       +   SD+IY+ T+  NPS P++  + + SSS+I L W PP  PNG +T Y++ W R  E    + F  D C  K                 +   NQ++ E    +C  SC K  +QIL  +++      F D      F+ +        E P+ + K    G         N TV V  V   FP+T  S+ S P+       F+K+V    N+     + L H+T Y  E+QAC    N  + E +               CS  + +SA T P+   D+I     +     + V + W EPK PNG I+ Y + YR+Y  E EL      CV+R  +                          LR L PG Y  +I+  ++A  G+WT+  +F +      T+Y +     A +II  L  +F+            R R         + SSNP+Y          +Y  D WE+ R+ + +L     LG+GSFGMVY+G  +++             E +  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   33 EVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVER-CWTHSHCQKVCPTICKSHG--CTAE--GLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK-VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYS----------FYALDNQNLRQLWD----WSKHNLTITQGKLFFHYNPKLCLSEIHK-MEEVSGTKGRQERND--IALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPP-DFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD--IDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAE--DSELFELDYCL-KGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECC-SCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVG------NVTVAVPTVAA-FPNT--SSTSVPTSPEEHRPFEKVV----NKESLVISGLRHFTGYRIELQAC----NQDTPEER---------------CSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDE-ELHL----CVSRKHFALERGC-------------------RLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYV------TDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLR---ELGQGSFGMVYEGNARDIIK----------GEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLG 1091          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  YLR    E E         L      A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+ SSD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GG L      N  + +  +M  CW +NP  RP+F +I+  L+     +F   S++
Sbjct: 1100 LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPD--NCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF 1304          

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTS-----EYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRN--FCLEFCPN------NCP----RGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDH-YAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYC----GRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPV-------------VIDNLLPAKRYAFYAEAIRS---RVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNK--NQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTR---------WVSSNPDYW--------IIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +VC  +DIR   + +  L NC+VIEG L I ++  T      + SFP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  +GL NL  +  G VRI+ N  LCY+ TI+W+ I+        ++N  +   C + CP       NCP     G+ +++ CW H+ CQ VC   C  +   C       CCH ECLG C    D   CV+C+N   +GRCV+ C   +Y +++ RC++ S C +L  +     R+  H Y I ++ C+ +C  G   N     C  C   C K  C    G   I S+    E  GC  I    I    GG++L+  L      +  I   L+I +S ++ SL F R LR+I+G +    N            F   DN+NL +++D     ++ N+TI +G + F+ N KLC  +I   +     TK +  + D  I   +NGD A C++E L    +  S     ++     P    ++     LF  +   +NV++++  ++C   +W  V+  I  P+             ++  L P  +YA + + + +       +   SD+IY+ T+  NPS P++  + + SSS+I L W PP  PNG +T Y++ W R  E    + F  D C  K                 +   NQ++ E    +C  SC K  +QIL  +++      F D      F     +P+ + K    G         N TV V  V   FP+T  S+ S P+       F+K+V    N+     + L H+T Y  E+QAC    N  + E +               CS  + +SA T P+   D+I     +     + V + W EPK PNG I+ Y + YR+Y  E EL      CV+R  +                          LR L PG Y  +I+  ++A  G+WT+  +F +      T+Y +     A +II  L  +F+            R R         + SSNP+Y          +Y  D WE+ R+ + +L     LG+GSFGMVY+G  +++             E +  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   33 EVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVER-CWTHSHCQKVCPTICKSHG--CTAE--GLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK-VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYS----------FYALDNQNLRQLWD----WSKHNLTITQGKLFFHYNPKLCLSEIHK-MEEVSGTKGRQERND--IALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPP-DFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD--IDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAE--DSELFELDYCL-KGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECC-SCPKTDSQILKELEESSFRKTFEDYLHNVVF-----VPRPSRKRRSLGDVG------NVTVAVPTVAA-FPNT--SSTSVPTSPEEHRPFEKVV----NKESLVISGLRHFTGYRIELQAC----NQDTPEER---------------CSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDE-ELHL----CVSRKHFALERGC-------------------RLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYV------TDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLR---ELGQGSFGMVYEGNARDIIK----------GEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLG 1079          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  YLR    E E         L      A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+ SSD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GG L      N  + +  +M  CW +NP  RP+F +I+  L+     +F   S++
Sbjct: 1088 LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPD--NCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF 1292          

Query:  213 SNEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSEYS---FPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINM-RNFCLEFCPNNCPRGENLQK---------YCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYG-EGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCGRVLIHSINDFSEA---EGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTVE------GYIGKPVVIDNLLPAKRYAFYAEAIR-SRVEN---WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLE---IFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGE-CDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLER----TRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            S E     IDIR     +  L NCTVIEG L+I +++   +Y    FP L  IT  L+++ V G ++LG  FPNLT+IRG  L YNYA+VI E TNL  IGL NLR +  G +RI+ N  LCY++T++W+ I+        + N     C + CP         +K          CW  N CQ +C  +C K  + C  N  N CCHPECLG C   + D  CV+C++    G CV  C    Y+++  RC+    C N+ S  S+D    + + I D  C+++C  G  +N      C  C   C K         +I+  + A   +GC   + ++ I+I+ G +  S+ L      + ++   ++I  S ++ SL FL++LR+I G    + N            F V DN+NL +++D     +  N+TI  G + F  N KLC  +I   +     TK + SK D  I   +NG+ A C+ + L       S +   +  H   P       + T  +  KE   KNV++Y+  ++C   +W  V+        +   +++  L P  +YA Y +A+  + VEN       S+++Y+ T    PS P+++ + + SSS++ + WNPP  PNG ++ YI+ W R  +   ++  ++  +D    +  +   I  +      KT      +G  C C K        +      K        + ++  S      +P+   K  D    ++     +   R      N  + D   I+ P  E L   +        N+     +NL  +T Y  +I +C       + E++ L             CS+ + + A T P E  D+I           +S+ + W EP++PNG IL Y I+Y     +         CV+R E+                   +K G   L  L PG Y  +I+  +++  G+WT    F + + + +  + +  I   V +++I+  L +++  + +K+   R      + S NP+Y+    +Y  D WE+ R+ + M   +  LG+GSFGMVY+GV K +            DE +  VA+KT+N  +++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   29 SGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGK--RACTEN--NECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSD---SEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASE-LENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYS----------FYVLDNQNLQQLWD----WDHRNLTIKAGKMYFAFNPKLCVSEIYR-MEEVTGTKGRQSKGD--INTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYY--KEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK------VFENFLHNSIF----VPRPERKRRDV--MQVANTTMSSRSR------NTTAADTYNITDP--EELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSC-------NHEAEKLG------------CSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQR------ECVSRQEY-------------------RKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITM---SRELGQGSFGMVYEGVAKGVVK----------DEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLG 1067          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEG---FVSENQSHL--WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    E E        + S +   A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI TLA  PY+G+S+  V+++V +GG L      N   +L  +M  CW YNP  RPSF +II  ++   +  FR  S+Y
Sbjct: 1076 LVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFY 1280          

Query:  213 SNEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSEYS---FPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINM-RNFCLEFCPNNCPRGENLQK---------YCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYG-EGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCGRVLIHSINDFSEA---EGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTVE------GYIGKPVVIDNLLPAKRYAFYAEAIR-SRVEN---WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLE---IFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGE-CDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLER----TRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            S E     IDIR     +  L NCTVIEG L+I +++   +Y    FP L  IT  L+++ V G ++LG  FPNLT+IRG  L YNYA+VI E TNL  IGL NLR +  G +RI+ N  LCY++T++W+ I+        + N     C + CP         +K          CW  N CQ +C  +C K  + C  N  N CCHPECLG C   + D  CV+C++    G CV  C    Y+++  RC+    C N+ S  S+D    + + I D  C+++C  G  +N      C  C   C K         +I+  + A   +GC   + ++ I+I+ G +  S+ L      + ++   ++I  S ++ SL FL++LR+I G    + N            F V DN+NL +++D     +  N+TI  G + F  N KLC  +I   +     TK + SK D  I   +NG+ A C+ + L       S +   +  H   P       + T  +  KE   KNV++Y+  ++C   +W  V+        +   +++  L P  +YA Y +A+  + VEN       S+++Y+ T    PS P+++ + + SSS++ + WNPP  PNG ++ YI+ W R  +   ++  ++  +D    +  +   I  +      KT      +G  C C K        +      K        + ++  S      +P+   K  D    ++     +   R      N  + D   I+ P  E L   +        N+     +NL  +T Y  +I +C       + E++ L             CS+ + + A T P E  D+I           +S+ + W EP++PNG IL Y I+Y     +         CV+R E+                   +K G   L  L PG Y  +I+  +++  G+WT    F + +   +  + +  I   V +++I+  L +++  + +K+   R      + S NP+Y+    +Y  D WE+ R+ + M   +  LG+GSFGMVY+GV K +            DE +  VA+KT+N  +++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   29 SGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGK--RACTEN--NECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSD---SEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASE-LENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYS----------FYVLDNQNLQQLWD----WDHRNLTIKAGKMYFAFNPKLCVSEIYR-MEEVTGTKGRQSKGD--INTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYY--KEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK------VFENFLHNSIF----VPRPERKRRDV--MQVANTTMSSRSR------NTTAADTYNITDP--EELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSC-------NHEAEKLG------------CSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQR------ECVSRQEY-------------------RKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKR-YENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITM---SRELGQGSFGMVYEGVAKGVVK----------DEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLG 1066          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEG---FVSENQSHL--WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    E E        + S +   A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI TLA  PY+G+S+  V+++V +GG L      N   +L  +M  CW YNP  RPSF +II  ++   +  FR  S+Y
Sbjct: 1075 LVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFY 1279          

Query:  186 ITFTDSFKLSNEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIA-MVTLTSE----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLIN-MRNFCLEFCPNNC-PRGENLQK---------YCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGC-YGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKK-YCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVE-----GYIGKP-VVIDNLLPAKRYAFYAEAIRSRVE----NWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQ-----FLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKI-SSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            I  +  F L   +VC S+DIR   + +  L NC+V+EG L I  M T T E     SFP L ++T  L+++ V G ++L   FPNL +IRG  L   YA+VI E  +L  + L  L  V+ G VR++ N  LC+++TI+W  +    GA   + N +   C + CP      GE   K          CW  + CQ VC      +   C       CCH ECLGGC   E    CV+C+++   G C+  C    Y+Y++ RC++   C +L S       R   + I   +C+ QC  G  +N  +  C  C   C K+   G   I SI    +  GC  +E   I     G +L   L  +   +  I   L+I  S ++ SL F ++L++I                + +    V DN+NL ++     A     +TI  G + F  N +LC E I   L     T+ + +K +  I   +NGD A C+   L   V N++++   +    +   +  ++     ++  +   +N +++   ++C  Q+W  ++         +P V + +L P  +YA +  AI    E    +    S ++YL T    P+ P ++ + + SSS + + W PP   NG +T Y++ ++ L   G D ++ D C    +  R   S ++ R    +   + + E DC  C       Q+L  ++  +   Q     FL   IT        IP S WK V S +   ++           +     S+D                    +VP        + L H+TEY  +I AC    +                    + CS+ + + A T P    D I         + +SV + W EP  PNG IL Y I+YR+   EA     +  CV+R                   +   K G   L  L PG Y  +++  ++A  G+WT S  F I   +       +  +    V + +L  L  L  +Y KK+   RT + S NP+Y+    +Y  D WE+ R+ + ++     LG+GSFGMVY+G+ + L             E+   VA+KT+N  ++  E  EF+ EA  MK F+ +H+V+L G
Sbjct:   16 IFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVCPGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQRVCP---CPHGMACTAR--GECCHTECLGGCSQPEDPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPG----RASTFGIHQGSCLAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNLRQGYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLI----------RGDAMVDGNYTLYVLDNQNLQQLGSWVAA----GLTIPVGKIYFAFNPRLCLEHIYR-LEEVTGTRGRQNKAE--INPRTNGDRAACQTRTLRF-VSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDG-DLYLNDYCH---RGLRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHP-PPGQVLPPLEAQEASFQKKFENFLHNAIT--------IPISPWK-VTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQED--------------KVPRERAV--LSGLRHFTEYRIDIHACNHAAH-------------------TVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPPDPNGLILKYEIKYRRLGEEA-----TVLCVSR-------------------LRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKR--NRTLYASVNPEYFSASDMYVPDEWEVPREQISIIR---ELGQGSFGMVYEGLARGLEA----------GEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLG 1047          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLG-IMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  +LR    E E      Q  L      A +IADGM YL+  KFVHRDLAARNCM++    +KIGDFGM RDVY   YYRK  KG LPVRWMAPESL  G F+  SD+WS+GV+LWEI+TLA  PY+G+S+  V+++V  GG L          L L  +M  CW  NP  RPSF  I+  ++     +FR  S+Y
Sbjct: 1056 LVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVL---EELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFY 1260          

Query:  219 EKVCQSIDIRKRS------------------HVSLLTNCTVIEGDLYIAMV-------------TLTSEYS------FPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRG-----------------------ENLQKYCWHHNTCQNVCS-ESCAKNNQYCFMNDPN-RCCHPECLGGCYGEGDE-MCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDA--CVKQCSPGKQQN--------KITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCY--SIEDIYISIKEGG---SSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNI-SDSSFTVKCHSKVPDISLQNSALTALFMLKETTK---NVSQYELFNSCSEQNWRTV-----EGYIGKPV--VIDNLLPAKR------YAFYAEA---IRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEI 2072
            EK C  IDIR R                       + NCTV+EG L I+ V             +L   YS      FP L+EITG+L+++  +G   L   FPNL +I G++L  +YA++I     L IGL  L ++  GGVRI +N  LCY  TI+W  ++      + + N   + +      CPRG                       E +Q  CW + TCQ  C+ +      +     D N   CH +C+GGC    D   C +CKNV   G+C++KCD   Y    RRC++  +C+ L+   S          I+  A  C  +C  G Q N        K  G+CEI    C        + H I+ F +A+     +I D  ++I+  G   S ++  L   F+ +  I   L + +SS   SL+  R+LR I          E  +         V++N NL ++FD        ++T+  G+VS   N+ LC + I   ++   +    L  +D+     +NG+ A C+   + V +  + +DS F       + DI  Q   L      KE  +   N++  E  ++C + +W++V     E   G+P   +  ++ P +R      YA+Y      + +  +N   +S + ++ T    P  P  L    + S  I +TW  PL PNG++T Y I +R  E+
Sbjct:   67 EKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQS-CWSNTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKT-----VPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIV---CE-------INHVIDTFPKAQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRI----------EAKSLFRNLYAITVFENPNLKKLFDSTT-----DLTLDRGTVSIANNKMLCFKYIKQLMS---KLNIPLDPIDQS--EGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDID-QRKFLGYELFFKEVPRIDENMTIEEDRSACVD-SWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNG--VSKIGFVRTSYYTPDPP-TLALAQVDSDAIHITWEAPLQPNGDLTHYTIMWRENEV 741          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGF----------VSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSY 4361
            +V+ME+M+ G+L  YLR + E+ E F          +  ++ H WA QI DGM YL  +KF HRDLAARNCMIN    +KIGDFGMARD++Y  YY+   K  +PVRWM+PESL  G F   SD+WS+GV+L+E++TL + PY G+S+ +V+ Y+     ++             +M+ CW Y+P DRP+F  ++  L   A   FR+ S+
Sbjct: 1249 MVVMEMMDLGNLRDYLRSKRED-EVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPEC-CENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAEASPEFRDLSF 1457          

Query:  219 EKVCQSIDIRKRS------------------HVSLLTNCTVIEGDLYIAMV-------------TLTSEYS------FPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRG-----------------------ENLQKYCWHHNTCQNVCSES----CAKNNQYCFMNDPNRCCHPECLGGCYGEGDE-MCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDA--CVKQCSPGKQQN--------KITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCY--SIEDIYISIKEGG---SSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNI-SDSSFTVKCHSKVPDISLQNSALTALFMLKETTK---NVSQYELFNSCSEQNWRTV-----EGYIGKPV--VIDNLLPAKR------YAFYAEA---IRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEI 2072
            EK C  IDIR R                       + NCTV+EG L I+ V             +L   YS      FP L+EITG+L+++  +G   L   FPNL +I G++L  +YA++I     L IGL  L ++  GGVRI +N  LCY  TI+W  ++      + + N   + +      CPRG                       E +Q  CW + TCQ  C+        +    C  N     CH +C+GGC    D   C +CKNV   G+C++KCD   Y    RRC++  +C+ L+   S          I+  A  C  +C  G Q N        K  G+CEI    C        + H I+ F +A+     +I D  ++I+  G   S ++  L   F+ +  I   L + +SS   SL+  R+LR I          E  +         V++N NL ++FD        ++T+  G+VS   N+ LC + I   ++   +    L  +D+     +NG+ A C+   + V +  + +DS F       + DI  Q   L      KE  +   N++  E  ++C + +W++V     E   G+P   +  ++ P +R      YA+Y      + +  +N   +S + ++ T    P  P  L    + S  I +TW  PL PNG++T Y I +R  E+
Sbjct:  143 EKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQS-CWSNTTCQKSCAYDRLLPTKEIGPGCDANGDR--CHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKT-----VPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIV---CE-------INHVIDTFPKAQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRI----------EAKSLFRNLYAITVFENPNLKKLFDSTT-----DLTLDRGTVSIANNKMLCFKYIKQLMS---KLNIPLDPIDQS--EGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDID-QRKFLGYELFFKEVPRIDENMTIEEDRSACVD-SWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNG--VSKIGFVRTSYYTPDPP-TLALAQVDSDAIHITWEAPLQPNGDLTHYTIMWRENEV 817          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGF----------VSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSY 4361
            +V+ME+M+ G+L  YLR + E+ E F          +  ++ H WA QI DGM YL  +KF HRDLAARNCMIN    +KIGDFGMARD++Y  YY+   K  +PVRWM+PESL  G F   SD+WS+GV+L+E++TL + PY G+S+ +V+ Y+     ++             +M+ CW Y+P DRP+F  ++  L   A   FR+ S+
Sbjct: 1325 MVVMEMMDLGNLRDYLRSKRED-EVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPEC-CENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAEASPEFRDLSF 1533          

Query:  219 EKVCQSIDIRKRS------------------HVSLLTNCTVIEGDLYIAMV-------------TLTSEYS------FPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRG-----------------------ENLQKYCWHHNTCQNVCSES----CAKNNQYCFMNDPNRCCHPECLGGCYGEGDE-MCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDA--CVKQCSPGKQQN--------KITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCY--SIEDIYISIKEGG---SSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNI-SDSSFTVKCHSKVPDISLQNSALTALFMLKETTK---NVSQYELFNSCSEQNWRTV-----EGYIGKPV--VIDNLLPAKR------YAFYAEA---IRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEI 2072
            EK C  IDIR R                       + NCTV+EG L I+ V             +L   YS      FP L+EITG+L+++  +G   L   FPNL +I G++L  +YA++I     L IGL  L ++  GGVRI +N  LCY  TI+W  ++      + + N   + +      CPRG                       E +Q  CW + TCQ  C+        +    C  N     CH +C+GGC    D   C +CKNV   G+C++KCD   Y    RRC++  +C+ L+   S          I+  A  C  +C  G Q N        K  G+CEI    C        + H I+ F +A+     +I D  ++I+  G   S ++  L   F+ +  I   L + +SS   SL+  R+LR I          E  +         V++N NL ++FD        ++T+  G+VS   N+ LC + I   ++   +    L  +D+     +NG+ A C+   + V +  + +DS F       + DI  Q   L      KE  +   N++  E  ++C + +W++V     E   G+P   +  ++ P +R      YA+Y      + +  +N   +S + ++ T    P  P  L    + S  I +TW  PL PNG++T Y I +R  E+
Sbjct:  143 EKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQS-CWSNTTCQKSCAYDRLLPTKEIGPGCDANGDR--CHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKT-----VPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIV---CE-------INHVIDTFPKAQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRI----------EAKSLFRNLYAITVFENPNLKKLFDSTT-----DLTLDRGTVSIANNKMLCFKYIKQLMS---KLNIPLDPIDQS--EGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDID-QRKFLGYELFFKEVPRIDENMTIEEDRSACVD-SWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNG--VSKIGFVRTSYYTPDPP-TLALAQVDSDAIHITWEAPLQPNGDLTHYTIMWRENEV 817          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGF----------VSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSY 4361
            +V+ME+M+ G+L  YLR + E+ E F          +  ++ H WA QI DGM YL  +KF HRDLAARNCMIN    +KIGDFGMARD++Y  YY+   K  +PVRWM+PESL  G F   SD+WS+GV+L+E++TL + PY G+S+ +V+ Y+     ++             +M+ CW Y+P DRP+F  ++  L   A   FR+ S+
Sbjct: 1325 MVVMEMMDLGNLRDYLRSKRED-EVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPEC-CENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAEASPEFRDLSF 1533          

Query:  219 EKVCQSIDIRKRS------------------HVSLLTNCTVIEGDLYIAMV-------------TLTSEYS------FPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRG-----------------------ENLQKYCWHHNTCQNVCS-ESCAKNNQYCFMNDPN-RCCHPECLGGCYGEGDE-MCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDA--CVKQCSPGKQQN--------KITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCY--SIEDIYISIKEGG---SSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNI-SDSSFTVKCHSKVPDISLQNSALTALFMLKETTK---NVSQYELFNSCSEQNWRTV-----EGYIGKPV--VIDNLLPAKR------YAFYAEA---IRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEI 2072
            EK C  IDIR R                       + NCTV+EG L I+ V             +L   YS      FP L+EITG+L+++  +G   L   FPNL +I G++L  +YA++I     L IGL  L ++  GGVRI +N  LCY  TI+W  ++      + + N   + +      CPRG                       E +Q  CW + TCQ  C+ +      +     D N   CH +C+GGC    D   C +CKNV   G+C++KCD   Y    RRC++  +C+ L+   S          I+  A  C  +C  G Q N        K  G+CEI    C        + H I+ F +A+     +I D  ++I+  G   S ++  L   F+ +  I   L + +SS   SL+  R+LR I          E  +         V++N NL ++FD        ++T+  G+VS   N+ LC + I   ++   +    L  +D+     +NG+ A C+   + V +  + +DS F       + DI  Q   L      KE  +   N++  E  ++C + +W++V     E   G+P   +  ++ P +R      YA+Y      + +  +N   +S + ++ T    P  P  L    + S  I +TW  PL PNG++T Y I +R  E+
Sbjct:   96 EKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQS-CWSNTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKT-----VPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIV---CE-------INHVIDTFPKAQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRI----------EAKSLFRNLYAITVFENPNLKKLFDSTT-----DLTLDRGTVSIANNKMLCFKYIKQLMS---KLNIPLDPIDQS--EGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDID-QRKFLGYELFFKEVPRIDENMTIEEDRSACVD-SWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNG--VSKIGFVRTSYYTPDPP-TLALAQVDSDAIHITWEAPLQPNGDLTHYTIMWRENEV 770          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGF----------VSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSY 4361
            +V+ME+M+ G+L  YLR + E+ E F          +  ++ H WA QI DGM YL  +KF HRDLAARNCMIN    +KIGDFGMARD++Y  YY+   K  +PVRWM+PESL  G F   SD+WS+GV+L+E++TL + PY G+S+ +V+ Y+     ++             +M+ CW Y+P DRP+F  ++  L   A   FR+ S+
Sbjct: 1278 MVVMEMMDLGNLRDYLRSKRED-EVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPEC-CENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAEASPEFRDLSF 1486          

Query:  219 EKVCQSIDIRKRS------------------HVSLLTNCTVIEGDLYIAMV-------------TLTSEYS------FPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRG-----------------------ENLQKYCWHHNTCQNVCSES----CAKNNQYCFMNDPNRCCHPECLGGCYGEGDE-MCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDA--CVKQCSPGKQQN--------KITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCY--SIEDIYISIKEGG---SSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNI-SDSSFTVKCHSKVPDISLQNSALTALFMLKETTK---NVSQYELFNSCSEQNWRTV-----EGYIGKPV--VIDNLLPAKR------YAFYAEA---IRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEI 2072
            EK C  IDIR R                       + NCTV+EG L I+ V             +L   YS      FP L+EITG+L+++  +G   L   FPNL +I G++L  +YA++I     L IGL  L ++  GGVRI +N  LCY  TI+W  ++      + + N   + +      CPRG                       E +Q  CW + TCQ  C+        +    C  N     CH +C+GGC    D   C +CKNV   G+C++KCD   Y    RRC++  +C+ L+   S          I+  A  C  +C  G Q N        K  G+CEI    C        + H I+ F +A+     +I D  ++I+  G   S ++  L   F+ +  I   L + +SS   SL+  R+LR I          E  +         V++N NL ++FD        ++T+  G+VS   N+ LC + I   ++   +    L  +D+     +NG+ A C+   + V +  + +DS F       + DI  Q   L      KE  +   N++  E  ++C + +W++V     E   G+P   +  ++ P +R      YA+Y      + +  +N   +S + ++ T    P  P  L    + S  I +TW  PL PNG++T Y I +R  E+
Sbjct:  143 EKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQS-CWSNTTCQKSCAYDRLLPTKEIGPGCDANGDR--CHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKT-----VPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIV---CE-------INHVIDTFPKAQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRI----------EAKSLFRNLYAITVFENPNLKKLFDSTT-----DLTLDRGTVSIANNKMLCFKYIKQLMS---KLNIPLDPIDQS--EGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDID-QRKFLGYELFFKEVPRIDENMTIEEDRSACVD-SWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNG--VSKIGFVRTSYYTPDPP-TLALAQVDSDAIHITWEAPLQPNGDLTHYTIMWRENEV 817          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGF----------VSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSY 4361
            +V+ME+M+ G+L  YLR + E+ E F          +  ++ H WA QI DGM YL  +KF HRDLAARNCMIN    +KIGDFGMARD++Y  YY+   K  +PVRWM+PESL  G F   SD+WS+GV+L+E++TL + PY G+S+ +V+ Y+     ++             +M+ CW Y+P DRP+F  ++  L   A   FR+ S+
Sbjct: 1407 MVVMEMMDLGNLRDYLRSKRED-EVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPEC-CENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAEASPEFRDLSF 1615          

Query:  216 NEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSEY--SFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP--------------RGE--------NLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGE--GDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEIC-GSECSKKYCGRVLIHSINDFSEAEGCYSI---EDIYISIK-EGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNV-------------SQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAE--AIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII 2051
            N K C+S+DIR   SH + L NCTVIEG L I ++   S    SFP L E+T  ++IY V G  +L   FPNL++IRG  L   YA+V+    +L+ +GL  LR +  GGVRI+ N  LCY  TI+W  I+ ++   + ++       E   + CP               GE        N ++ CW+   CQ  C E C  N   C   D + CC  +CLGGC  +  G+E C+SC+NV  N  C+  C K +Y++ + RC++ +EC+ L+   +        Y   +  C+  C  G Q+++    CE C G +C K+ C   LI S+    E  GC  I   E + ISIK E G+ + D L    + +  I++SL +  +  + SL F +SL  I         +             V DN +L E++      NQ  + I +G V F+ N KLC   I   L           K D  +   SNG+   C    L V + ++  +S  +   +KV +I        A  + K+    +             S     + C ++ W+         +V+ NL+P   Y++Y    AI S + N    SDV    T    PS+   +    +S S+I +TW+    P G +TRY I
Sbjct:  335 NVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNRSFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTKCPEKCRNN---CI--DEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQF-DSRCVTANECITLTKFETNSVYSGIPY---NGQCITHCPTGYQKSENKRMCEPCPGGKCDKE-CSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEI---------SGDPPMDADKYALYVLDNRDLDELW----GPNQ-TVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSD--VGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKV-EIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDR-WKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAE--SDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFI 964          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGE-----------GFVSENQSHLW------AIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELY-ADMNFRNNSYY 4364
            LV+MELM+ GDL  YLR    E             G     Q   +      AI+IADGM YL+  KFVHRDLAARNCM+   L +KIGDFGM RD+Y   YYRK  KG LPVRWM PESL  G +S +SD++S+GV+LWE+ TLA+ PY+G+S+  V++YV  GG +      N    L  +M+ CW +    RPSF DII  LE    +  F+  S+Y
Sbjct: 1448 LVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPE--NCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFY 1665          

Query: 2496 QVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTIN---TRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSS--NPDYWII-YEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            ++P N+T+F F  L H+T Y   + AC+     +   S+ L      K++    CS    +   T  K+  D + +  ++        S V++ W+ P  PNG I+ Y + Y+               + +P+ +     +     N      Q +G+  L  L  G Y F+++  +IA  G +T+  H K+     + +   +F +  + +  ++ +LF  VCY  K+K       +++  NP Y  + Y  D WE+ R+++  L    PLG+GSFGMVY+G+LK+      D+            A+KT+N N+T  ER  F++EA  MK+F +YH+V+L G
Sbjct: 1143 ELPPNQTHFVFEKLRHFTRYAIFVVACR-----EEIPSEKLRDTSFKKSL----CSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYK---------------LQKPDQVEEKKCIPAADFN------QTAGY--LIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKV--FFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLA---PLGQGSFGMVYEGILKSFPPNGVDRE----------CAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLG 1439          

Query:  216 NEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSEY--SFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP--------------RGE--------NLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGE--GDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEIC-GSECSKKYCGRVLIHSINDFSEAEGCYSI---EDIYISIK-EGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNV-------------SQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAE--AIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII 2051
            N K C+S+DIR   SH + L NCTVIEG L I ++   S    SFP L E+T  ++IY V G  +L   FPNL++IRG  L   YA+V+    +L+ +GL  LR +  GGVRI+ N  LCY  TI+W  I+ ++   + ++       E   + CP               GE        N ++ CW+   CQ  C E C  N   C   D + CC  +CLGGC  +  G+E C+SC+NV  N  C+  C K +Y++ + RC++ +EC+ L+   +        Y   +  C+  C  G Q+++    CE C G +C K+ C   LI S+    E  GC  I   E + ISIK E G+ + D L    + +  I++SL +  +  + SL F +SL  I         +             V DN +L E++      NQ  + I +G V F+ N KLC   I   L           K D  +   SNG+   C    L V + ++  +S  +   +KV +I        A  + K+    +             S     + C ++ W+         +V+ NL+P   Y++Y    AI S + N    SDV    T    PS+   +    +S S+I +TW+    P G +TRY I
Sbjct:  335 NVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNRSFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTKCPEKCRNN---CI--DEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQF-DSRCVTANECITLTKFETNSVYSGIPY---NGQCITHCPTGYQKSENKRMCEPCPGGKCDKE-CSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEI---------SGDPPMDADKYALYVLDNRDLDELW----GPNQ-TVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSD--VGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKV-EIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDR-WKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAE--SDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFI 964          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGE-----------GFVSENQSHLW------AIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELY-ADMNFRNNSYY 4364
            LV+MELM+ GDL  YLR    E             G     Q   +      AI+IADGM YL+  KFVHRDLAARNCM+   L +KIGDFGM RD+Y   YYRK  KG LPVRWM PESL  G +S +SD++S+GV+LWE+ TLA+ PY+G+S+  V++YV  GG +      N    L  +M+ CW +    RPSF DII  LE    +  F+  S+Y
Sbjct: 1448 LVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPE--NCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFY 1665          

Query: 2496 QVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTIN---TRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSS--NPDYWII-YEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            ++P N+T+F F  L H+T Y   + AC+     +   S+ L      K++    CS    +   T  K+  D + +  ++        S V++ W+ P  PNG I+ Y + Y+               + +P+ +     +     N      Q +G+  L  L  G Y F+++  +IA  G +T+  H K+     + +   +F +  + +  ++ +LF  VCY  K+K       +++  NP Y  + Y  D WE+ R+++  L    PLG+GSFGMVY+G+LK+      D+            A+KT+N N+T  ER  F++EA  MK+F +YH+V+L G
Sbjct: 1143 ELPPNQTHFVFEKLRHFTRYAIFVVACR-----EEIPSEKLRDTSFKKSL----CSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYK---------------LQKPDQVEEKKCIPAADFN------QTAGY--LIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKV--FFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLA---PLGQGSFGMVYEGILKSFPPNGVDRE----------CAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLG 1439          

Query:  216 NEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSEY--SFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP--------------RGE--------NLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGE--GDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEIC-GSECSKKYCGRVLIHSINDFSEAEGCYSI---EDIYISIK-EGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNV-------------SQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAE--AIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII 2051
            N K C+S+DIR   SH + L NCTVIEG L I ++   S    SFP L E+T  ++IY V G  +L   FPNL++IRG  L   YA+V+    +L+ +GL  LR +  GGVRI+ N  LCY  TI+W  I+ ++   + ++       E   + CP               GE        N ++ CW+   CQ  C E C  N   C   D + CC  +CLGGC  +  G+E C+SC+NV  N  C+  C K +Y++ + RC++ +EC+ L+   +        Y   +  C+  C  G Q+++    CE C G +C K+ C   LI S+    E  GC  I   E + ISIK E G+ + D L    + +  I++SL +  +  + SL F +SL  I         +             V DN +L E++      NQ  + I +G V F+ N KLC   I   L           K D  +   SNG+   C    L V + ++  +S  +   +KV +I        A  + K+    +             S     + C ++ W+         +V+ NL+P   Y++Y    AI S + N    SDV    T    PS+   +    +S S+I +TW+    P G +TRY I
Sbjct:  335 NVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNRSFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTKCPEKCRNN---CI--DEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQF-DSRCVTANECITLTKFETNSVYSGIPY---NGQCITHCPTGYQKSENKRMCEPCPGGKCDKE-CSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEI---------SGDPPMDADKYALYVLDNRDLDELW----GPNQ-TVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSD--VGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKV-EIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDR-WKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAE--SDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFI 964          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGE-----------GFVSENQSHLW------AIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELY-ADMNFRNNSYY 4364
            LV+MELM+ GDL  YLR    E             G     Q   +      AI+IADGM YL+  KFVHRDLAARNCM+   L +KIGDFGM RD+Y   YYRK  KG LPVRWM PESL  G +S +SD++S+GV+LWE+ TLA+ PY+G+S+  V++YV  GG +      N    L  +M+ CW +    RPSF DII  LE    +  F+  S+Y
Sbjct: 1448 LVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPE--NCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFY 1665          

Query: 2496 QVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTIN---TRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSS--NPDYWII-YEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            ++P N+T+F F  L H+T Y   + AC+     +   S+ L      K++    CS    +   T  K+  D + +  ++        S V++ W+ P  PNG I+ Y + Y+               + +P+ +     +     N      Q +G+  L  L  G Y F+++  +IA  G +T+  H K+     + +   +F +  + +  ++ +LF  VCY  K+K       +++  NP Y  + Y  D WE+ R+++  L    PLG+GSFGMVY+G+LK+      D+            A+KT+N N+T  ER  F++EA  MK+F +YH+V+L G
Sbjct: 1143 ELPPNQTHFVFEKLRHFTRYAIFVVACR-----EEIPSEKLRDTSFKKSL----CSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYK---------------LQKPDQVEEKKCIPAADFN------QTAGY--LIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKV--FFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLA---PLGQGSFGMVYEGILKSFPPNGVDRE----------CAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLG 1439          

Query:  216 NEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSEY--SFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP--------------RGE--------NLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGE--GDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEIC-GSECSKKYCGRVLIHSINDFSEAEGCYSI---EDIYISIK-EGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNV-------------SQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAE--AIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII 2051
            N K C+S+DIR   SH + L NCTVIEG L I ++   S    SFP L E+T  ++IY V G  +L   FPNL++IRG  L   YA+V+    +L+ +GL  LR +  GGVRI+ N  LCY  TI+W  I+ ++   + ++       E   + CP               GE        N ++ CW+   CQ  C E C  N   C   D + CC  +CLGGC  +  G+E C+SC+NV  N  C+  C K +Y++ + RC++ +EC+ L+   +        Y   +  C+  C  G Q+++    CE C G +C K+ C   LI S+    E  GC  I   E + ISIK E G+ + D L    + +  I++SL +  +  + SL F +SL  I         +             V DN +L E++      NQ  + I +G V F+ N KLC   I   L           K D  +   SNG+   C    L V + ++  +S  +   +KV +I        A  + K+    +             S     + C ++ W+         +V+ NL+P   Y++Y    AI S + N    SDV    T    PS+   +    +S S+I +TW+    P G +TRY I
Sbjct:  335 NVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNRSFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTKCPEKCRNN---CI--DEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQF-DSRCVTANECITLTKFETNSVYSGIPY---NGQCITHCPTGYQKSENKRMCEPCPGGKCDKE-CSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEI---------SGDPPMDADKYALYVLDNRDLDELW----GPNQ-TVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSD--VGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKV-EIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDR-WKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAE--SDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFI 964          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGE-----------GFVSENQSHLW------AIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELY-ADMNFRNNSYY 4364
            LV+MELM+ GDL  YLR    E             G     Q   +      AI+IADGM YL+  KFVHRDLAARNCM+   L +KIGDFGM RD+Y   YYRK  KG LPVRWM PESL  G +S +SD++S+GV+LWE+ TLA+ PY+G+S+  V++YV  GG +      N    L  +M+ CW +    RPSF DII  LE    +  F+  S+Y
Sbjct: 1448 LVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPE--NCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFY 1665          

Query: 2496 QVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTIN---TRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSS--NPDYWII-YEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            ++P N+T+F F  L H+T Y   + AC+     +   S+ L      K++    CS    +   T  K+  D + +  ++        S V++ W+ P  PNG I+ Y + Y+               + +P+ +     +     N      Q +G+  L  L  G Y F+++  +IA  G +T+  H K+     + +   +F +  + +  ++ +LF  VCY  K+K       +++  NP Y  + Y  D WE+ R+++  L    PLG+GSFGMVY+G+LK+      D+            A+KT+N N+T  ER  F++EA  MK+F +YH+V+L G
Sbjct: 1143 ELPPNQTHFVFEKLRHFTRYAIFVVACR-----EEIPSEKLRDTSFKKSL----CSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYK---------------LQKPDQVEEKKCIPAADFN------QTAGY--LIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKV--FFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLA---PLGQGSFGMVYEGILKSFPPNGVDRE----------CAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLG 1439          

Query:  141 LKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLT---SEYSFPTLK----EITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYN-YAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIV----RQHGAPIKLINMRNFC---------LEFCPNNCPRGENLQKYCWHHNTCQ--------NVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEI-CGSECSKKYCGRVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLN--ISD-SSFTVKCHSKVPDISLQNSALTALFMLKET-TKNVSQYELFNSCSEQNW-RTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEI---SDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII 2051
            + IS+   +I L+   +        ++  C S++I K + +  L NCT + G + +A V LT     YS  +L     EI+  L++Y   G  +L   FP L IIRGQ L ++ Y++V+ E  NL  +GLV L  +  G +R+++NP LC+V T++W  ++    RQH + +K    ++ C          EF  N+  R       CW+ NT Q          C  +C  N      +   +CC   C+ GCY +    C  C N      CV +C    Y+   RRCI   EC  L               I    CVK+C PG Q+  +  +  I C  EC+    G   + S  D    + C +I   + I +      + D L  A + +  I   L+++ S+ + SL FL++L  I+G+   +N               V +N +L  I+      N L + I  G++ F+LN +LC EKI   L  ++++   +S  D  +   SNG+   C      V+ LN  + D +S  V+      D     + +   +  KE   +NV+ Y+  + C   NW   V     +  VI  L P  +YA++ + + +R E  ++I   S + Y  T    PS  + +   +  SS+I L W PP  PNG +  Y +
Sbjct:   13 IPISIAVPLILLFLGASSPVLASSDDQTACGSLEINKIADLRKLQNCTHVVGHVRLAYVDLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFS-LKHNRPQSQCPLCGSLSADFEFIRNSSER-------CWNVNTTQLRPQPPRLKDCPIACGLNG----CDSAGKCCDHNCVTGCYSQN---CSLCANYQGRMGCVNQCVA-SYELNKRRCIGHRECRELGRIP----------LIRGYQCVKKC-PGNQKEILVAKGIIHCQVECN----GDFHVKSAADLEVLQDCVTINGSLTIELTNIKEKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKY----------ALYVVNNYHLEHIWPP----NHL-VIIQRGTLFFHLNPRLCYEKIHQ-LQGSLKSGENISVAD--VSPNSNGERVICGDA---VRSLNPKVEDLNSTAVRIILDYMDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLMDVVPNQSRRHVISGLKPYTQYAYFVKTL-TRTEYHIQIDAYSKIGYFQTLPDRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYFV 636          

Query:  213 SNEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE-----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNF-CLEFCPNN------CPR---GENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCY-GEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPG-KQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHS-KVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLE------ISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDT-IMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTV-----RVDEVVTNFPST--DISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYY-CKKKYLERTR---WVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +N ++C S DIR   +++ +L NCTVIEG L I ++  T        S+P L  +T  L+++ V G ++L   FPNLT++RG  L +NYA+V+ E   L  IGL +L  +  G VR++ NP LCY++T++W+ I+        + N  +  C + CP        CP      +  + CW+   CQ +C  SC   ++ C  +  ++CCH +CLGGC        CV+C+N + N  CV+KC   FY +K  RC+S S C  L ++          Y I + AC+ +C  G    N  T  C  C   C K   G   + S+       GC  I    +    GG++++  L     +L  I   L +  S ++ SL FLR LRII G +    N            F   DN+NL +++D     ++ N+TI +G + F+ N KLC  +I   +     TK + +K D  I++ +NGD A C+ + L    ++       +K  +   PD       L  + + KE   KNV++++  ++C   +W         R  EG   +P  +  + P K +  YA  +++++    E       S++IY+ T    PS P++  + + SSS+I L W PP  PNG +T Y+++ +  +    + +  D C    K   R  +Q +N   +  N  + QG  D   C  +C K +  +  + ++T   +  + Y+       NE+            FE++     +++     R    +   PS+  + S    P  E   N    +VQ  A E+    +NL H+T Y  EI AC    N  S  ++               CS  + +SA T P+E  D+I    I   V   SV I W EPK+PNG I+ Y + Y++     EL      CV+R  ++                     G   LR + PG Y  +I+  ++A  G+WT+  HF +    +  +  N   I    +I     L + V +Y  KKK  E      + S NP+Y+    +YE D WE+ R+ + +L     LG+GSFGMVY+G  K++             E Q  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   22 TNGEICSSKDIRNNVTNLRVLENCTVIEGHLKILLMFTTKPEDFRGLSYPKLTVVTDYLLLFRVYGLESLSDLFPNLTVVRGNNLFFNYALVLFEMLQLKEIGLHSLMNITRGAVRVEKNPDLCYLSTLDWSMILDSVEDNYIVANKNDRECGDICPGTVLGKTTCPLTTINGDFSERCWNQKYCQRMCPSSC--KHRACTKD--SQCCHDQCLGGCLEPHSSNKCVACRNFMHNNMCVEKCPHGFYTFKGWRCVSFSFCQELHNKCKQGKGDCHEYVIHNGACIPECPSGYTTVNSTTLNCTPCAGLCPKVCMGLKTVDSVTAAQALRGCTVINGSLVINIRGGNNIAAELEANLGQLEEITGYLTVRHSYALVSLSFLRKLRIIHGETQEVGNYS----------FYALDNQNLRQLWD----WSKHNLTIQQGRMFFHHNSKLCMSEIRR-MEEVTGTKNRQTKND--IVSKTNGDQASCESKVLKFTRISTLSDKIIIKWEAFWPPDF---RDLLGFMVLYKEAPYKNVTEFDGQDACGSNSWVIADVDPPPRATEGKEHEPGYL--IFPLKPWTQYAIMVKTQLSASDEHQVHGAKSEIIYVRTNATKPSVPLDPISSSNSSSQIILKWKPPNDPNGNITHYLVFCQQ-QPEASELYKFDYCQKGMKLPTRAPTQVDNEEEQKWNQTEEQGP-DSRCC--ACPKTEKQLKKEAEETEYRKTFENYL------HNEV------------FELRPSRQRRSLVGIANRTSSRLFTTPSSLPNGSATRSPEEEAEANKISLIVQ--AKESTV-ISNLRHFTSYQIEIHAC----NHGSDPTR---------------CSMAAYVSARTMPEEKADDI-VGKITCEVFEYSVHIRWIEPKAPNGMIILYEVHYKRLGDTEELHH----CVSRKNYI-------------------ADGGCKLRVVHPGNYTVRIRATSLAGNGSWTEPTHFYVQ--DLRVDPSNVLKIVIGPVICFFLLLLLCVGFYIVKKKQTEGPTGRLYTSPNPEYFSPDEVYEPDEWEVPREKITLLR---ELGQGSFGMVYEGNGKDIVK----------GESQTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLG 1062          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  +LR    + E         L      A +IADGM YL+  KFVHRDLAARNCM+   L +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+  SD WS+GV+LWE+ TLA  PY+G+S+  V+++V +GG L      N +  L  +M+ CW YNP  RP+F +II+ L      +F+  S++
Sbjct: 1071 LVVMELMTHGDLKSFLRSLRPDSENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEVSTLAEQPYQGLSNEQVLKFVMEGGYLDRPD--NCADRLHNLMQMCWHYNPKMRPTFQEIIEMLREDLHPSFQEVSFF 1275          

Query:  222 KVCQSIDIRK-RSHVSLLTNCTVIEGDLYIAMVTLTSE-----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNF-CLEFCPN------NCPR---GENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPG-KQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSN-GDMAFCKHEKL-IVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGKP-VVIDNLLPAKRYAFYAEAIRSRVENWL---EISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIW--YRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQ---NQGECDCDKCMESCNKNQILINIDKDDT-IMQFLDEYITKSFIKQNEI--PKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSS--VKIFWSEPKSPNGFILNYFIRYRKYP--YEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRW---VSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            ++C S DIR   +++ +L NCTVIEG L I ++  T++      SFP L  +T  L+I+ V G ++LG  FPNLT+IRG  L +NYA+V+ E   +  IGL +L  +  G VRI+ NP+LCY++T++W+ I+        + N  +  C   CP       +C +     N  + CW+ N CQ +C   C     +        CCH +CLGGC   G+   CV+C+N L    CV +C   +Y +K+ RC+S   C +L +Q          Y I + AC+ +C  G    N  +  C  C   C K   G   + S+       GC  +    I    GG+S++  L  +  +L  I   L I ++ ++ SL FLR L +I+G + +  N            F   DN+NL +++D     N+ N+TIL+G + F  N KLC  +IL    +   T TK      R+ ++SN  D ++C+   L   Q+  +SD    ++  S  P  S     L  + + KE   +NV++Y+  ++C   +W         R  EG   +P  +I  L P  +YA   +A  +  E+       +++IY+ T    PS P++  + + SSS+I L W PP  PNG +T YII+   +S +I    F   D C    K      +  +    +  N  +    +G C C     +C K ++ +  + ++T   +  + Y+       NE+  P+ + +    G        +  T     ++ NFP+T I    K          +KMV   +++     +NL H+T Y  EI AC D  +                      CS  + + A T P+   D I E   +         V I W EPK+PNG I+ Y ++Y +    YE ++      CV+R                   I+ +K+  Y LR   PG Y  +++  ++A  G+WT   +F +       E     +I   + I +L  L  +  +  KKK  E        SSNP+Y     +Y  D WE+ R+ + ++     LG+GSFGMVY+G+ K++             E    VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   26 EICPSTDIRNIATNLRVLENCTVIEGHLKILLMFKTTQEDFRGLSFPKLVMVTDYLLIFRVYGLESLGSLFPNLTVIRGSNLFFNYALVMFEMIQMKEIGLHSLTNITRGAVRIEKNPNLCYLSTLDWSKILDSVEDNYIVANKDDLECGNICPGTIAGTISCKQTTINGNFGERCWNQNHCQRICPSECV----HGACTSHKECCHEQCLGGCSVPGNSTKCVACRNFLYGEACVDRCPPGYYTFKSWRCVSLQFCQDLHNQCKDKSGDCHAYVIHNGACIPECPSGYTTVNSTSLTCMPCTGRCPKVCTGVQTVDSVTAAQALRGCTVLNGSLIIKISGGNSIAAELESSLGQLEEITGYLTIRRAYALVSLSFLRKLHLIRGETLDGGNYS----------FHAMDNQNLRQLWD----WNKHNLTILKGRMKFIQNGKLCKSEILRMEQA---TGTK-----NRMNDISNEKDQSYCESHILKFTQIRTMSD-KILIRWESFWP--SDFRDLLGFMVLYKEAPHRNVTEYDGQDACGSNSWAIADVEPPQRPSEGKEVEPGYLIMPLKPWTQYAVMVKAQLAASEDHQVRGAKTEIIYVRTNATRPSVPLDPHSWSNSSSQIILKWKPPSDPNGNITHYIIYCQKQSEDITHYKF---DYCQQGMKVPSHTPTHHDVEEDQKLNQTEVPDQKGHC-C-----ACPKTEMQLKKEAEETEFRKTFENYL------HNEVFEPRPHRRRRSVGVANATLPNFGTT---PTIIPNFPTTSIPEEEKS---------RKMVFKASSKEAMVISNLLHFTSYQIEIHACNDPTDPGR-------------------CSMPTYVKARTLPELKADVIAEPVTHEFFPDEPDVVYIRWKEPKTPNGMIILYEVKYLRMSDNYEDQI------CVSR-------------------ISYEKNHGYRLRVGHPGNYSVRVRATSLAGNGSWTDPAYFYVQD----REMSMKIVIILAICIFLLVILASVGYFVLKKKQTEGPTGPLIASSNPEYISANDVYIPDEWEVPREKITVMR---ELGQGSFGMVYEGIAKDIIK----------GEPDTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLG 1057          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  YLR    + E         L      + +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+  SD WS+GV+LWEI TLA  PY+G+S+  V+++V  GG L      N  + +  +M+ CW YNP  RP+F +II+ ++      F+  S++
Sbjct: 1066 LVVMELMTHGDLKSYLRSLRPDAENNPGSPPPTLKEMIQMSAEIADGMAYLNAKKFVHRDLAARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGYL--DRPENCPERMHNLMQMCWQYNPKMRPTFHEIIEMIKEDLHPTFQEVSFF 1270          

Query:  270 LTNCTVIEGDLYIAMV--------TLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP--RGENLQ-KYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGC-YGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITG-----RCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTV------EGYIGKPVVIDNLLPAKRYAFYAEAI------RSRVENWLEI---SDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDD--FFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYR--KYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTR----------WVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            L NCTVIEG L I ++         +    SFP L  IT  L+++ V G ++L   FPNL +IRG+ L YNYA+VI E T+L  IGL NLR +  G +RI+ NP LCY+++++W+ I+    A +      N   + C N CP    +N Q   CW  N CQ VC   C +  + C   D  +CCHP+CLG C   + D  C +C+N    GRCV+ C    YK++  RCI+   C   S     DY   D + I    C+  C PG  +++  G      C  C   C  K C   +I S++     +GC  I+ +++I+I+  G++++  L      +  +   ++I  S ++TSL FL+SLR I                + +  F   DN++L  ++D     +Q N+TI EG + F LN KLC  +I     +    K    + D R    +NGD A C  + L     N   +   +   S  P  S     +  +   KE   +N+++++  +SC   +W  V      E  +   VV+  L P  +YA + +A+      R R ++ L +   S+V+Y+ T+   PS P++++  + SSS++ + W PPL PNG  T Y++ ++     G+D   +  + C  + K   R+ +        T   N   G  D   C       + L  I+ D    +  + ++  +        +          F +  V    T+       N    + S    P  E         ++    E + + T L  +T Y  ++ AC   + V+                    CS+ + + + T   E  D+I   ++       SV + W EP  PNG I+ Y I+YR    P + E       CV+R  +                   +K     L +L PG Y  +++  ++A  G+WT+   F +       E  +Y  +  + I+  L  +  LV +     ++ + R          + S NP+Y+   E+   D WE++R+ + M      LG+GSFGMVY+G+ K +            DE +  VA+KT+N ++++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   45 LENCTVIEGYLQILLIGDKNSNNQEVFRTLSFPKLTMITDYLLLFRVSGLESLSTLFPNLAVIRGRNLFYNYALVIFELTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSVDWSLIL---DAELNNFIDGNKQSKECGNVCPGIMEDNSQCTRCWTSNHCQKVC--RCGQ--RAC--TDSGQCCHPQCLGSCSVPDSDRACAACQNYNHEGRCVEDCPPGTYKFEGWRCITRDFC---SKVHLPDY---DRFVIHAGECMSDCPPGFTRDESHGVSVSMLCTACDGPCD-KICDEKVIDSVDAAQSLKGCTVIKGNLHINIRR-GTNIASELENFLGLIKTVTGYIKIRSSHTLTSLSFLKSLRYI----------HGEELWDNTYAFAALDNQHLQLLWD----WSQHNLTISEGKLYFRLNPKLCMSEIRKMW-AKTGIKDNFVERDFR----NNGDRASCGTKILKFTSNNTRSNQIKLMWESYRPSDS--RDLVNFIVYYKEAPFQNITEFDGQDSCGSDSWNMVDVDLPDEKILNPGVVLSALKPWTQYAIFVKAVTLIVEDRDRDKDRLHLGPQSEVVYIRTKPSAPSMPVDIRAYSNSSSKLVVRWAPPLAPNGNNTYYLLRWKQQ---GEDRELYQHNYCSKELKIPVRVSATGLTDTEDTKPTNHETGGRDKTPCCPCPKTEEDLKRIEDDIYYRKAFENFLHNAIFTPRPPDRRR-----RDLFGVANVTSIHTLLAGH--WNLTEGNFSDDEPPRRE------FSFLERKVKERHIEITGLQPFTVYRIDLHACN--EEVRH-------------------CSAAAFVFSRTKAAEKADDI-PGSVTWEGQEDSVFLKWPEPDKPNGLIMLYEIQYRLGTEPEKHE-------CVSRQHY-------------------RKHKGVKLSNLGPGNYSVRVRATSLAGNGSWTEPIAFSVHQ----LEQSSYDPVMFIAILPALLLIAGLVVF--GYTWMNKNRNNDRLGNGVLYASVNPEYFSAAEMYVPDEWEVEREKITMCR---ELGQGSFGMVYEGIAKGVVK----------DEPETRVAIKTVNESASLHERIEFLNEASVMKEFNCHHVVRLLG 1055          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL----------WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR           EN S L           A +IADGM YL+  KFVHRDLAARNCM+    I+KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI TLA  PY+GMS+  V+++V +GG L      N   +L  +M  CW YNP  RPSF +II  ++   +  F+  S++
Sbjct: 1064 LVIMELMTRGDLKSYLRSLRS------VENTSSLPLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFIVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTMSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEDLEAGFKETSFF 1267          

Query:  237 IDIRKR-SHVSLLTNCTVIEGDLYIAMV-----TLTSEY----SFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIV-RQHGAPIKLINMRNFCLEFCPN------NCPR---GENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCY-GEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCGRVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKC---HSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTV------EGYIGKPVVIDNLLPAKRYAFYAEAIRSRVEN---WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXX------XXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSS--VKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEW--LNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNY------XXXXXXXXXXXXXXXXXXXXYYCKKKYLER----TRWVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            IDIR   +    L NCTV+EG L I ++      L  E+    SFP L  +T  ++++ V G  +L + FPNL +IRG+ L YNYA+VI E T+L  IGL NLR +  G +RI+ NP LCY+++++W+ ++  +    I        C + CP       +C R    +N    CW  N CQ VC + C K  + C   D  +CCHP+CLG C   + D+ C +C++     RCV+ C    YK++  RCI+   C  +   S  D      + I +  C+  C PG  +N+     C  C   C  K C    I S++     +GC  I+ ++ I+I+ G +  S+ L      +  +   +RI  + ++ SL FL+SLR I                + +  F   DN NL  ++D      Q N+TI  G + F  N KLC  +I          + K+++ D R    SNG+ A C  E  I++  +    S  +K      + PD       ++ +   KE   +N+++++  + C   +W  V      E  I   V++  L P  +YA + +A+   VE+       S+V+Y+ T    PS P++ +    SSS + + W+PP+ PNG  T Y + W +  E    + +  + C  +        +      +   + +K++     +G C C K  E            +D +  +  + ++  S            +P D    ++  V  N T+ V  V  N  S   S I++P +      F    +   +  + +  NL  +T Y  +I AC                     N     CS+ + + + T P +  D+I  S    R       V + W EP  PNG IL Y I+YR    EAE       CV+R ++  L G                       L +L  G Y  +++  ++A  G+WT+   F +         RNY       II  V+++++L  + V V    KK+  +R      + S NP+Y+  +E+   D WE+ R+ + M      LG+GSFGMVY+G+ K +            DE +  VA+KT+N ++++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   37 IDIRNDITEFKKLENCTVVEGYLQILLIGDKNNNLNQEHFRTLSFPKLTMVTDYILLFRVSGLDSLSVLFPNLNVIRGRNLFYNYALVIFEMTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSVDWSLLMDAEFNNYIAGNKQSKECGDVCPGINEDRPHCIRTSFNDNYSYRCWTSNHCQKVCPKECEK--RAC--TDAGQCCHPQCLGSCTEADNDKACAACQHYFHEDRCVEACPPDTYKFEGWRCITMEMCARVHLPSEVD------FVIHNGECMPDCPPGFTRNETQSMFCSACDGLCD-KVCESKTIDSVDAAQSLQGCTVIKGNLQINIRRGNNIASE-LESFMGLIQTVTGYVRIKHTHTLGSLSFLKSLRYI----------VGEELVDNTYAFHAVDNHNLQYLWD----WTQHNLTIKTGKLYFRFNPKLCMSEIRKMW-EKTSVREKMAEDDVR----SNGERASC--ESYILKFRSNHTQSTRIKLTWERYRPPDY---RDLISFIVYYKEAPFQNITEFDGQDGCGSNSWNMVDVDLPQEKSIDPGVLLSPLKPWTQYAIFVKAVTLVVEDKHVGGAKSEVVYIRTNASAPSMPLDARAYANSSSSLMVKWSPPIAPNGNKTFYFLRWQQQAE--DGELYQHNYCSKELKIPIRISATSLSDMEGETKPTKSDVAGGEKGCCPCPKTKEDLKAEA------EDRSYRKVFENFLHNSIFTP--------RPPDRKRRDLMGVA-NSTL-VSGVSRNI-SVLESNITQPELPEKEYPFS---EGKVHTEFMEIHNLRPFTVYRIDIHAC---------------------NYEVHRCSAAAFVFSRTKPADKADDIPGSVTQERDEKGEGIVLLRWPEPLHPNGLILMYEIKYR-LGTEAE----KHECVSRQQYKVLRGAQ---------------------LSNLASGNYSARVRATSLAGNGSWTEPVSFYVPPPK-----RNYDNAFYVAIIIPVIVLLLLLFVIVAVIIVTKKRNSDRIGNGVLYASVNPEYFSPFEMYVPDEWEVAREKITMCR---ELGQGSFGMVYEGIAKGVVK----------DEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLG 1065          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  +LR    + +G  S++   L      A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+ +SD+WS+GV+LWEI TLA  PY+GMS+  V+++V +GG L      N   +L  +M  CW YNP  RPSF +II  ++   +  FR  S++
Sbjct: 1074 LVIMELMTRGDLKSHLRSLRSKEQGSSSQSLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPSFLEIINSIKEELEPPFREVSFF 1278          

Query:  222 KVC-QSIDIRKR-SHVSLLTNCTVIEGDLYIAMV-----TLTSEY----SFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIV-RQHGAPIKLINMRNFCLEFCPN------NCPR---GENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCY-GEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCGRVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKC---HSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTV------EGYIGKPVVIDNLLPAKRYAFYAEAIRSRVEN---WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXX------XXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSS--VKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEW--LNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNY------XXXXXXXXXXXXXXXXXXXXYYCKKKYLER----TRWVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +VC   IDIR   +    L NCTV+EG L I ++      L  E+    SFP L  +T  ++++ V G  +L + FPNL +IRG+ L YNYA+VI E T+L  IGL NLR +  G +RI+ NP LCY+++++W+ ++  +    I        C + CP       +C R    +N    CW  N CQ VC + C K  + C   D  +CCHP+CLG C   + D+ C +C++     RCV+ C    YK++  RCI+   C  +   S  D      + I +  C+  C PG  +N+     C  C   C  K C    I S++     +GC  I+ ++ I+I+ G +  S+ L      +  +   +RI  + ++ SL FL+SLR I                + +  F   DN NL  ++D      Q N+TI  G + F  N KLC  +I          + K+++ D R    SNG+ A C  E  I++  +    S  +K      + PD       ++ +   KE   +N+++++  + C   +W  V      E  I   V++  L P  +YA + +A+   VE+       S+V+Y+ T    PS P++ +    SSS + + W+PP+ PNG  T Y + W +  E    + +  + C  +        +      +   + +K++     +G C C K  E            +D +  +  + ++  S            +P D    ++  V  N T+ V  V  N  S   S I++P +      F    +   +  + +  NL  +T Y  +I AC                     N     CS+ + + + T P +  D+I  S    R       V + W EP  PNG IL Y I+YR    EAE       CV+R ++  L G                       L +L  G Y  +++  ++A  G+WT+   F +         RNY       II  V+++++L  + V V    KK+  +R      + S NP+Y+  +E+   D WE+ R+ + M      LG+GSFGMVY+G+ K +            DE +  VA+KT+N ++++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   59 EVCGPHIDIRNDITEFKKLENCTVVEGYLQILLIGDKNNNLNQEHFRTLSFPKLTMVTDYILLFRVSGLDSLSVLFPNLNVIRGRNLFYNYALVIFEMTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSVDWSLLMDAEFNNYIAGNKQSKECGDVCPGINEDRPHCIRTSFNDNYSYRCWTSNHCQKVCPKECEK--RAC--TDAGQCCHPQCLGSCTEADNDKACAACQHYFHEDRCVEACPPDTYKFEGWRCITMEMCARVHLPSEVD------FVIHNGECMPDCPPGFTRNETQSMFCSACDGLCD-KVCESKTIDSVDAAQSLQGCTVIKGNLQINIRRGNNIASE-LESFMGLIQTVTGYVRIKHTHTLGSLSFLKSLRYI----------VGEELVDNTYAFHAVDNHNLQYLWD----WTQHNLTIKTGKLYFRFNPKLCMSEIRKMW-EKTSVREKMAEDDVR----SNGERASC--ESYILKFRSNHTQSTRIKLTWERYRPPDY---RDLISFIVYYKEAPFQNITEFDGQDGCGSNSWNMVDVDLPQEKSIDPGVLLSPLKPWTQYAIFVKAVTLVVEDKHVGGAKSEVVYIRTNASAPSMPLDARAYANSSSSLMVKWSPPIAPNGNKTFYFLRWQQQAE--DGELYQHNYCSKELKIPIRISATSLSDMEGETKPTKSDVAGGEKGCCPCPKTKEDLKAEA------EDRSYRKVFENFLHNSIFTP--------RPPDRKRRDLMGVA-NSTL-VSGVSRNI-SVLESNITQPELPEKEYPFS---EGKVHTEFMEIHNLRPFTVYRIDIHAC---------------------NYEVHRCSAAAFVFSRTKPADKADDIPGSVTQERDEKGEGIVLLRWPEPLHPNGLILMYEIKYR-LGTEAE----KHECVSRQQYKVLRGAQ---------------------LSNLASGNYSARVRATSLAGNGSWTEPVSFYVPPPK-----RNYDNAFYVAIIIPVIVLLLLLFVIVAVIIVTKKRNSDRIGNGVLYASVNPEYFSPFEMYVPDEWEVAREKITMCR---ELGQGSFGMVYEGIAKGVVK----------DEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLG 1093          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  +LR    + +G  S++   L      A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+ +SD+WS+GV+LWEI TLA  PY+GMS+  V+++V +GG L      N   +L  +M  CW YNP  RPSF +II  ++   +  FR  S++
Sbjct: 1102 LVIMELMTRGDLKSHLRSLRSKEQGSSSQSLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPSFLEIINSIKEELEPPFREVSFF 1306          

Query:  225 VCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLK-----EITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNF--CLEFCPNNCPRGE---------NLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGD-EMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKK-YCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQ--------NSALTALFMLKETT-KNVSQYELFNSCSEQNWRTVEGYIG------KPVVIDNLLPAKRYAFYAEAIRSRVEN----WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQ-----FLDE--YITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYT---LRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRR-KFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSY 4361
            +C S+DIR   S    L NCTVI+G+L I ++  T    F  L+      IT  L+++ V G ++L   FPNL+IIRG  L ++Y++VI E  +L  IGL +L  ++ G VRI+ N  LC+++TI+W S++ +      ++  +    C + CP     GE         N++  CW   +CQ VC     K +  C  ++   CCHPECLGGC   GD   CV+C+N   + +C+  C    ++Y+  RCI E+ C NL  +S         + I ++ C+ +C  G  +N  +  C  C   C K    G  +I S+    E  GC +IE   I     G +L+  L ++   +  I   L+I  S ++ SL F ++L++I+G++    N              + DN+NL++++  +      +++I  G + F  N KLC  +I   +     T+ + +K D  I   +NGD A C       +  NI    F V   ++   I+L+        +  L+ +   KE+  +N+++Y   ++C   +W  V+  +         V + NL P  +YA Y  AI    E     +   SDV+Y+ T    P+ P ++   + SSS + + W PP   NG +T Y++ ++ + +   + ++ + C   +K  +   S ++ R    +NGNQ+  +   DKC   C K+  L + + D+   Q     FL    +I K+  ++ ++P  N  P   G+  + +   + T+       N    D    SKP          +MV           +NL H+TEY  +I AC     +                   + CS+ + + A T      DNI  +        +++ + W EPK+PNG IL Y I+Y++                        N+V +       +++Q+   Y    L  L+PG Y  +I+  ++A  G+WT+   F I             ++ ++                     L  +R+  ++     +Y  D WE  R+++ +++    LG+GSFGMVY+GV K++            +E    VA+KT+N  +T  ER EF+NEA  MK F  +H+V+L G+VS+   + +  +   R   K +  S+    + P++                  +I    ID +     G+  A +      +P              YL             NQ  L      A +IADGM YL+  KFVHRDLAARNCM++  L +KIGDFGM RD+Y   YYRK  K  LPVRWM+PESL  G F+  SD+WS+GV+LWEI TLA  PY+GM++  V+ +V   G L      N    L  +M  CW  NP  RPSF  I++ ++     +F+  S+
Sbjct:   31 ICGSMDIRNDVSQFRKLENCTVIQGNLQILLMFSTKPEDFRGLRFERLTMITEYLLLFRVYGLESLRDLFPNLSIIRGTDLFFHYSLVIFEMPHLRDIGLYSLTNILNGAVRIERNQELCHISTIDW-SLLSESVENNYIVGNKPVEECADVCPGIRDSGESCIKTPINGNMESRCWTSTSCQKVCP---CKEDIAC--SNTGECCHPECLGGCNKAGDPRACVACRNFYIDDQCLPSCPPGTFEYEGWRCIEEAYCGNLLKESENS--ESTKFVIFENRCLSECPSGYTRNDSSIFCHKCEGLCPKTCKAGNKVIDSLEAAKELTGCTNIEGNLILNIRRGHNLASELQQSLGLIETITGFLKIKHSFALVSLSFFKNLKLIRGDTMVDGNY----------TLYILDNQNLLQLWTPE------SLSIPVGKLYFAFNPKLCLSEIY-HMEEITGTRGRQNKAD--INPRTNGDQASC-------ESCNIRPLRF-VSNWTEADRINLKWERYQPPGHDLLSFVVHYKESPFQNITEYLGQDACGANSWNVVDVELPLNNEQEPSVTLTNLKPWVQYAIYVRAITLTAEENGRKFGAQSDVVYIRTRPAAPTVPQDVMIMSNSSSHLIVRWKPPTQRNGNLTYYLVLWQQM-VEDKELYLNNYC---TKGLKLPTSSADTRFDNDDNGNQDPNQDTEDKCC-PCQKDGGL-HPEMDEGSFQKKFENFLRNTIFIPKAPKRRRDVPGMN--PEVLGNASLPEGTVSHTI-------NHTGVD----SKPYSYKDKVFLNRMV----------ISNLRHFTEYRIDIHACNHAAEI-------------------VGCSAATFVFARTMQDPLADNIVGNITWEVTAKNAILMKWEEPKNPNGLILKYEIKYKR------------------------NMVCEGPPTVVCVSRQQFQRYKGVHLTLLQPGNYSARIRATSLAGNGSWTEPMVFFILGPGKLVTPGTLKVLNSLPHPTS----------------LNLSRYHPTHVLCTTVYVPDEWEFPRENITIIK---ELGQGSFGMVYEGVAKDIVK----------NEPVTRVALKTVNELATTRERIEFLNEASVMKAFLCHHVVRLLGVVSQGQPALVIMELMTRGDLKSYLRSLRPDEEVPIH-----------------GQIVAADIDPLDG--LGNLSARVGAETTAIP------------DRYLNNH--------PGNQPSLKRMIQMAGEIADGMAYLTAKKFVHRDLAARNCMVSEDLTVKIGDFGMTRDIYETDYYRKGGKSLLPVRWMSPESLKDGIFTTYSDVWSFGVVLWEIATLAEQPYQGMANEQVLHFVIDNGIL--EKPENCPDRLHELMRWCWQKNPKHRPSFIQILESIKDELPTSFQQVSF 1287          

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE------YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP---RGENLQKY----------CWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKK---YCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGKP-VVIDNLLPAKRYAFYAEAIRSRVE---NWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDE-------YITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYC---KKKYLE---RTRWVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            K+C S+DIR   S  S+L +CTVIEG L I ++  TS+        FP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  IGL NL  +  G VRI+ N  LCY++TI+W+ I+         +N  N   E C + CP   +G++  K           CW  + CQ VC   C  +   C  +   +CCH ECLG C    D   C +C++    G C+  C +  Y+++  RCI  + C  + ++          Y I    C+  C  G   N  T  C  C   C K    Y     I S+    E  GC  +    I    GG++++  L      +  I   L+I +S ++ SL F R LR+I+G      N            F   DN +L +++D     ++ N+TI+ G + F+ N +LC  +I   +     TK +  K D  I   +NGD A C+   L    +  S     +K     P        L  +   KE   +NV++++  ++C   +W         R+ +G    P  ++ NL P  +YA + + + S  +    +   S +IY+ T    PS P++  + + S+S+I L W PP  PNG VT Y+++++  +    + +  D C   +K  +              NGN NQ +    KC   C K    I  ++D++  +   E       +I +   K+ E+            F +        V    +  N  ST     ++P I +    FK+ + V         T L H+T Y  EI AC                     + L++ CS  + +SA T P+   DN+        +  + + + W EPK PNG I+ Y + Y +     E+      CV++ ++   T+  AK                 LR L PG Y  +I+  ++A  G+WT+  +F++       ++ +  I+  V   +I   L + V  YC   KKK  E      + SSNP+Y    E+   D WE+ R  + +L     LG+GSFGMVY+G+ K++             E ++ VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   43 KICPSMDIRNNISQFSMLEDCTVIEGHLQI-LLMFTSKPENFRGLRFPKLTMITDYLLLFRVYGLESLKDLFPNLTVIRGTHLFFNYALVIFEMVHLKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSIILDSVEDNYIELNRDN--KEECGDVCPGAGKGKSKCKQIVVNGAFIERCWTQDHCQTVCPSECKGSG--CLPD--GQCCHSECLGSCRKPNDPTECTACRHYQYQGVCISACPEGSYRFQGWRCIDFNTCQEMHNRCPNKENSCPPYVIHKGECMPDCPSGYIANSTTRTCTPCAGPCPKVCTIYQSVKTIDSVTSAQELRGCTVVNGSLIINIRGGNNIATELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGEVLEAGNYS----------FYALDNPSLRQLWD----WHKHNLTIIHGKLFFHHNPRLCLAEIHQ-MEEVTGTKGRQDKND--ISTKTNGDQASCEDNLLNFNFIRTSHDMVLLKWDPYWP--PDYRDLLGFMVHYKEAPYQNVTEFDGQDACGSNSWTVVDMDAPERSADGKTLSPGCLLRNLKPWTQYAVFVKTLVSGSDEGRTYGAKSKIIYIRTNETIPSVPLDPFSVSNSTSQIILKWKPPSEPNGNVTHYLVYWQE-QPEDSELYELDYC---NKGLKLPSRTWTPPSDIEENGNINQTDQPSSKCC-PCPKTDFQIQKEQDESAFRKTFENYLHNEVFIPRPVRKRREL------------FGVANGTLPDPVTAPSLF-NASSTRAPDETEPKIYSQKVWFKESLMV---------TGLKHFTGYRIEIHACN--------------------HELSMGCSVAAYVSARTMPEATADNVVGPITYEYIEPNIIHLKWQEPKDPNGLIVLYEVHYSRVGGTEEV----ISCVSQKQY--STDKGAK-----------------LRVLTPGNYSVKIRATSLAGNGSWTEPAYFQVP------DHPHSSIVKIVTGPVIAVILLLFVLVYCVIQKKKDAEGPVGPLYASSNPEYLSASEVYIPDEWEVPRDKISLLR---ELGQGSFGMVYEGIAKDIIK----------GEPEVRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLG 1078          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    + E         L      A +I+DGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GGSL      N    L  +M+ CW YNP  RP+F +II  L+    ++F+  S+Y
Sbjct: 1087 LVIMELMTHGDLKSYLRSLRPDAENNPGRPAPTLKEMIQMAAEISDGMAYLNAKKFVHRDLAARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGSL--DQPENCPPRLHSLMQMCWQYNPKMRPTFLEIIDMLKDDLHLSFQEVSFY 1291          

Query:  219 EKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE------YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP---RGENLQKY----------CWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKK---YCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGKP-VVIDNLLPAKRYAFYAEAIRSRVE---NWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDE-------YITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYC---KKKYLERT---RWVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            E  C S+DIR   S  S+L +CTVIEG L I ++  TS+        FP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  IGL NL  +  G VRI+ N  LCY++TI+W+ I+         +N  N   E C + CP   +G++  K           CW  + CQ VC   C  +   C  +   +CCH ECLG C    D   C +C++    G C+  C +  Y+++  RCI  + C  + ++          Y I    C+  C  G   N  T  C  C   C K    Y     I S+    E  GC  +    I    GG++++  L      +  I   L+I +S ++ SL F R LR+I+G      N            F   DN +L +++D     ++ N+TI+ G + F+ N +LC  +I   +     TK +  K D  I   +NGD A C+   L    +  S     +K     P        L  +   KE   +NV++++  ++C   +W         R+ +G    P  ++ NL P  +YA + + + S  +    +   S +IY+ T    PS P++  + + S+S+I L W PP  PNG VT Y+++++  +    + +  D C   +K  +              NGN NQ +    KC   C K    I  ++D++  +   E       +I +   K+ E+            F +        V    +  N  ST     ++P I +    FK+ + V         T L H+T Y  EI AC                     + L++ CS  + +SA T P+   DN+        +  + + + W EPK PNG I+ Y + Y +     E+      CV++ ++   T+  AK                 LR L PG Y  +I+  ++A  G+WT+  +F++       ++RN  I+  V   +I   L + V  YC   KKK  E      + SSNP+Y    E+   D WE+ R  + +L     LG+GSFGMVY+G+ K++             E ++ VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:    5 ELFCPSMDIRNNISQFSMLEDCTVIEGHLQI-LLMFTSKPENFRGLRFPKLTMITDYLLLFRVYGLESLKDLFPNLTVIRGTHLFFNYALVIFEMVHLKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSIILDSVEDNYIELNRDN--KEECGDVCPGAGKGKSKCKQIVVNGAFIERCWTQDHCQTVCPSECKGSG--CLPD--GQCCHSECLGSCRKPNDPTECTACRHYQYQGVCISACPEGSYRFQGWRCIDFNTCQEMHNRCPNKENSCPPYVIHKGECMPDCPSGYIANSTTRTCTPCAGPCPKVCTIYQSVKTIDSVTSAQELRGCTVVNGSLIINIRGGNNIATELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGEVLEAGNYS----------FYALDNPSLRQLWD----WHKHNLTIIHGKLFFHHNPRLCLAEIHQ-MEEVTGTKGRQDKND--ISTKTNGDQASCEDNLLNFNFIRTSHDMVLLKWDPYWP--PDYRDLLGFMVHYKEAPYQNVTEFDGQDACGSNSWTVVDMDAPERSADGKTLSPGCLLRNLKPWTQYAVFVKTLVSGSDEGRTYGAKSKIIYIRTNETIPSVPLDPFSVSNSTSQIILKWKPPSEPNGNVTHYLVYWQE-QPEDSELYELDYC---NKGLKLPSRTWTPPSDIEENGNINQTDQPSSKCC-PCPKTDFQIQKEQDESAFRKTFENYLHNEVFIPRPVRKRREL------------FGVANGTLPDPVTAPSLF-NASSTRAPDETEPKIYSQKVWFKESLMV---------TGLKHFTGYRIEIHACN--------------------HELSMGCSVAAYVSARTMPEATADNVVGPITYEYIEPNIIHLKWQEPKDPNGLIVLYEVHYSRVGGTEEV----ISCVSQKQY--STDKGAK-----------------LRVLTPGNYSVKIRATSLAGNGSWTEPAYFQVP------DHRN-SIVKIVTGPVIAVILLLFVLVYCVIQKKKDAEGPVGPLYASSNPEYLSASEVYIPDEWEVPRDKISLLR---ELGQGSFGMVYEGIAKDIIK----------GEPEVRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLG 1040          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    + E         L      A +I+DGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GGSL      N    L  +M+ CW YNP  RP+F +II  L+    ++F+  S+Y
Sbjct: 1049 LVIMELMTHGDLKSYLRSLRPDAENNPGRPAPTLKEMIQMAAEISDGMAYLNAKKFVHRDLAARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGSL--DQPENCPPRLHSLMQMCWQYNPKMRPTFLEIIDMLKDDLHLSFQEVSFY 1253          

Query:  225 VCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE------YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP---RGENLQKY----------CWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKK---YCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGKP-VVIDNLLPAKRYAFYAEAIRSRVE---NWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDE-------YITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISS-----DSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +C S+DIR   S  S+L +CTVIEG L I ++  TS+        FP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  IGL NL  +  G VRI+ N  LCY++TI+W+ I+         +N  N   E C + CP   +G++  K           CW  + CQ VC   C  +   C  +   +CCH ECLG C    D   C +C++    G C+  C +  Y+++  RCI  + C  + ++          Y I    C+  C  G   N  T  C  C   C K    Y     I S+    E  GC  +    I    GG++++  L      +  I   L+I +S ++ SL F R LR+I+G      N            F   DN +L +++D     ++ N+TI+ G + F+ N +LC  +I   +     TK +  K D  I   +NGD A C+   L    +  S     +K     P        L  +   KE   +NV++++  ++C   +W         R+ +G    P  ++ NL P  +YA + + + S  +    +   S +IY+ T    PS P++  + + S+S+I L W PP  PNG VT Y+++++  +    + +  D C   +K  +              NGN NQ +    KC   C K    I  ++D++  +   E       +I +   K+ E+            F +        V    +  N  ST     ++P I +    FK+ + V         T L H+T Y  EI AC                     + L++ CS  + +SA T P+   DN+        +  + + + W EPK PNG I+ Y + Y +     E+      CV++ ++   T+  AK                 LR L PG Y  +I+  ++A  G+WT+  +F++        SI   Y                       +Y   +      + SSNP+Y    E+   D WE+ R  + +L     LG+GSFGMVY+G+ K++             E ++ VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   20 ICPSMDIRNNISQFSMLEDCTVIEGHLQI-LLMFTSKPENFRGLRFPKLTMITDYLLLFRVYGLESLKDLFPNLTVIRGTHLFFNYALVIFEMVHLKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSIILDSVEDNYIELNRDN--KEECGDVCPGAGKGKSKCKQIVVNGAFIERCWTQDHCQTVCPSECKGSG--CLPD--GQCCHSECLGSCRKPNDPTECTACRHYQYQGVCISACPEGSYRFQGWRCIDFNTCQEMHNRCPNKENSCPPYVIHKGECMPDCPSGYIANSTTRTCTPCAGPCPKVCTIYQSVKTIDSVTSAQELRGCTVVNGSLIINIRGGNNIATELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGEVLEAGNYS----------FYALDNPSLRQLWD----WHKHNLTIIHGKLFFHHNPRLCLAEIHQ-MEEVTGTKGRQDKND--ISTKTNGDQASCEDNLLNFNFIRTSHDMVLLKWDPYWP--PDYRDLLGFMVHYKEAPYQNVTEFDGQDACGSNSWTVVDMDAPERSADGKTLSPGCLLRNLKPWTQYAVFVKTLVSGSDEGRTYGAKSKIIYIRTNETIPSVPLDPFSVSNSTSQIILKWKPPSEPNGNVTHYLVYWQE-QPEDSELYELDYC---NKGLKLPSRTWTPPSDIEENGNINQTDQPSSKCC-PCPKTDFQIQKEQDESAFRKTFENYLHNEVFIPRPVRKRREL------------FGVANGTLPDPVTAPSLF-NASSTRAPDETEPKIYSQKVWFKESLMV---------TGLKHFTGYRIEIHACN--------------------HELSMGCSVAAYVSARTMPEATADNVVGPITYEYIEPNIIHLKWQEPKDPNGLIVLYEVHYSRVGGTEEV----ISCVSQKQY--STDKGAK-----------------LRVLTPGNYSVKIRATSLAGNGSWTEPAYFQVPDHLNTYPSIMCMY----------------------FFYRDAEGPVGPLYASSNPEYLSASEVYIPDEWEVPRDKISLLR---ELGQGSFGMVYEGIAKDIIK----------GEPEVRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLG 1037          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    + E         L      A +I+DGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GGSL      N    L  +M+ CW YNP  RP+F +II  L+    ++F+  S+Y
Sbjct: 1046 LVIMELMTHGDLKSYLRSLRPDAENNPGRPAPTLKEMIQMAAEISDGMAYLNAKKFVHRDLAARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGSL--DQPENCPPRLHSLMQMCWQYNPKMRPTFLEIIDMLKDDLHLSFQEVSFY 1250          

Query:  228 CQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE------YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP---RGENLQKY----------CWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKK---YCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGKP-VVIDNLLPAKRYAFYAEAIRSRVE---NWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDE-------YITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISS-----DSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            C S+DIR   S  S+L +CTVIEG L I ++  TS+        FP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  IGL NL  +  G VRI+ N  LCY++TI+W+ I+         +N  N   E C + CP   +G++  K           CW  + CQ VC   C  +   C  +   +CCH ECLG C    D   C +C++    G C+  C +  Y+++  RCI  + C  + ++          Y I    C+  C  G   N  T  C  C   C K    Y     I S+    E  GC  +    I    GG++++  L      +  I   L+I +S ++ SL F R LR+I+G      N            F   DN +L +++D     ++ N+TI+ G + F+ N +LC  +I   +     TK +  K D  I   +NGD A C+   L    +  S     +K     P        L  +   KE   +NV++++  ++C   +W         R+ +G    P  ++ NL P  +YA + + + S  +    +   S +IY+ T    PS P++  + + S+S+I L W PP  PNG VT Y+++++  +    + +  D C   +K  +              NGN NQ +    KC   C K    I  ++D++  +   E       +I +   K+ E+            F +        V    +  N  ST     ++P I +    FK+ + V         T L H+T Y  EI AC                     + L++ CS  + +SA T P+   DN+        +  + + + W EPK PNG I+ Y + Y +     E+      CV++ ++   T+  AK                 LR L PG Y  +I+  ++A  G+WT+  +F++        SI   Y                       +Y   +      + SSNP+Y    E+   D WE+ R  + +L     LG+GSFGMVY+G+ K++             E ++ VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   28 CPSMDIRNNISQFSMLEDCTVIEGHLQI-LLMFTSKPENFRGLRFPKLTMITDYLLLFRVYGLESLKDLFPNLTVIRGTHLFFNYALVIFEMVHLKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSIILDSVEDNYIELNRDN--KEECGDVCPGAGKGKSKCKQIVVNGAFIERCWTQDHCQTVCPSECKGSG--CLPD--GQCCHSECLGSCRKPNDPTECTACRHYQYQGVCISACPEGSYRFQGWRCIDFNTCQEMHNRCPNKENSCPPYVIHKGECMPDCPSGYIANSTTRTCTPCAGPCPKVCTIYQSVKTIDSVTSAQELRGCTVVNGSLIINIRGGNNIATELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGEVLEAGNYS----------FYALDNPSLRQLWD----WHKHNLTIIHGKLFFHHNPRLCLAEIHQ-MEEVTGTKGRQDKND--ISTKTNGDQASCEDNLLNFNFIRTSHDMVLLKWDPYWP--PDYRDLLGFMVHYKEAPYQNVTEFDGQDACGSNSWTVVDMDAPERSADGKTLSPGCLLRNLKPWTQYAVFVKTLVSGSDEGRTYGAKSKIIYIRTNETIPSVPLDPFSVSNSTSQIILKWKPPSEPNGNVTHYLVYWQE-QPEDSELYELDYC---NKGLKLPSRTWTPPSDIEENGNINQTDQPSSKCC-PCPKTDFQIQKEQDESAFRKTFENYLHNEVFIPRPVRKRREL------------FGVANGTLPDPVTAPSLF-NASSTRAPDETEPKIYSQKVWFKESLMV---------TGLKHFTGYRIEIHACN--------------------HELSMGCSVAAYVSARTMPEATADNVVGPITYEYIEPNIIHLKWQEPKDPNGLIVLYEVHYSRVGGTEEV----ISCVSQKQY--STDKGAK-----------------LRVLTPGNYSVKIRATSLAGNGSWTEPAYFQVPDHLNTYPSIMCMY----------------------FFYRDAEGPVGPLYASSNPEYLSASEVYIPDEWEVPRDKISLLR---ELGQGSFGMVYEGIAKDIIK----------GEPEVRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLG 1044          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    + E         L      A +I+DGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GGSL      N    L  +M+ CW YNP  RP+F +II  L+    ++F+  S+Y
Sbjct: 1053 LVIMELMTHGDLKSYLRSLRPDAENNPGRPAPTLKEMIQMAAEISDGMAYLNAKKFVHRDLAARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGSL--DQPENCPPRLHSLMQMCWQYNPKMRPTFLEIIDMLKDDLHLSFQEVSFY 1257          

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTS-----EYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRN--FCLEFCPN------NCP----RGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDH-YAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYC----GRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPV---------------VIDNLLPAKRYAFYAEAIRS---RVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCN----KNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTR---------WVSSNPDYW--------IIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +VC  +DIR   + +  L NC+VIEG L I ++  T      + SFP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  +GL NL  +  G VRI+ N  LCY+ TI+W+ I+        ++N  +   C + CP       NCP     G+ +++ CW H+ CQ VC   C  +   C       CCH ECLG C    D   CV+C+N   +G+CV+ C   +Y +++ RC++ S C +L  +     +   H Y I ++ C+ +C  G   N     C  C   C K  C    G   I S+    E  GC  I    I    GG++L+  L      +  I   L+I +S ++ SL F R L +I+G +    N            F   DN+NL +++D     ++ N+TI +G + F+ N KLC  +I   +     TK +  + D  I   +NGD A C++E L    +  S     ++     P    ++     LF  +   +NV++++  ++C   +W  V+  I  P                ++  L P  +YA + + + +       +   SD+IY+ T+  NPS P++  + + SSS+I L W PP  PNG +T Y++ W R  E    + F  D C    K  +      +      ++   NQ E D D   E C+     +QIL  +++      F D      F+ +   P    + ++         E          + +FP  ++S+   P+ +     F+K+V    N+     + L H+T Y  E+QAC    N  S + +               CS  + +SA T P+   D+I     +     + V + W EPK PNG I+ Y + YR+Y  E EL      CV+R  +                          LR L PG Y  +++  ++A  G+WT+  +F +      T+Y +     A +II  L  +F+            R R         + SSNP+Y          +Y  D WE+ R+ + +L     LG+GSFGMVY+G  K++             E +  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   33 EVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVER-CWTHSHCQKVCPTICKSHG--CTAE--GLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPK-VCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYS----------FYALDNQNLRQLWD----WSKHNLTITQGKLFFHYNPKLCLSEIHK-MEEVSGTKGRQERND--IALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPP-DFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD--IDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAE--DSELFELDYCL---KGLKLPSRTWSPPFESDDSQKHNQSEYD-DSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPR---PSRKRRSLE---------EVGNVTATTLTLPDFP--NVSSTIVPTSQEEHRPFEKVV----NKESLVISGLRHFTGYRIELQAC----NQDSPDER---------------CSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDE-ELHL----CVSRKHFALERGC-------------------RLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYV------TDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLR---ELGQGSFGMVYEGNAKDIIK----------GEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLG 1081          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAI-----QIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  +LR    + E         L  +     +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+ SSD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GG L      N  + L  +M  CW +NP  RP+F +I+  L+     +F   S++
Sbjct: 1090 LVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPD--NCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF 1294          

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIA-MVTLTSE----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP-----RGENLQK---------YCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGC-YGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKK-YCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVE-----GYIGKP-VVIDNLLPAKRYAFYAEAI----RSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQ-----FLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKK--MVQVPANETYFK------------FTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISS-DSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +VC S+DIR   + +  L NC+V+EG L I  M   T E     SFP L ++T  L+++ V G ++L   FPNLT+IRG  L   YA++I E  +L  +GL +L  V+ G VR++ N  LC+++TI+W  +     AP     + N   E C + CP      GE   +          CW  + CQ VC   C +        D   CCH ECLGGC   E    CV+C+++   G C++ C    Y+Y++ RC++   C +L             + I + +C+ QC PG  +N  +  C  C   C K+   G   I S+    +  GC  +E   I     G +L   L +    +  I   L+I  S ++ +L F ++L++I             +  + +    V DN+NL ++     A     +TI  G + F  N +LC E I   L     T+ + SK +  I   +NGD A C+   L   V N+++    +    +   +  ++     ++  +   +N +++   ++C  Q+W  ++         +P V +  L P  +YA +  AI         +    S ++YL T    P+ P ++ + + SSS + + W PP+  NG +T Y++ ++ L   G D ++ D C    +          +R          QG C C    +     Q L  ++  +   Q     FL   IT        IPK+ WK                               +++I+K    +   H ++  ++++  N + F+             + L H+TEY  +I AC    +                    + CS+ + + A T P    D I           SSV + W EP  PNG IL Y I+YR+   EA     +  CV+R                   +   K G   L  L PG Y  +++  ++A  G+WT    F I+  +   T     F+    V  ++L  L  L  +Y +K+    T + S NP+Y+    +Y  D WE+ R+ + ++     LG+GSFGMVY+G+ + L             E+   VA+KT+N  ++  ER EF+ EA  MK F+ +H+V+L G
Sbjct:   28 EVCPSLDIRSEVTELRRLENCSVVEGHLQILLMFAATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLTVIRGTRLFLGYALIIFEMPHLRDVGLPSLGAVLRGAVRVEKNQELCHLSTIDWGLL---QPAPGTNHIVGNKLGEECADVCPGVLGAAGEPCSRTTFSGRTDYRCWTSSHCQKVC--PCPRGMACTAGGD---CCHSECLGGCSQPEDPRACVACRHLYFQGVCLRACPPGTYQYESWRCVTAELCAHLREVPGL----ATTFGIYEGSCLAQCPPGFTRNGSSIFCHKCEGLCPKECKVGTKTIDSVQATQDLVGCTHVEGNLILNLRQGYNLEPELQRNLGLVETITGFLKIKHSFALVTLGFFKNLKLI----------RGDSMVDGNYTLYVLDNQNLQQLGSWVTA----GLTIPVGKIYFAFNPRLCLEHIYQ-LEEVTGTRGRQSKAE--INPRTNGDRAACQTRTLRF-VFNLTEEDRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLAPLKPWTQYAVFVRAITLTTAEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPVQRNGNITYYLVLWQRLAEDG-DLYINDYCHRGLRLPTSSHDTRFDREDPALEAEPEQGCCPC----QHSPPGQALPALEAQEVTFQKKFENFLHHAIT--------IPKAPWK-------------------------------VTSINKNPQRDSERHRREAGLLRLGKNNSDFEIQEDKVPRERAILSGLRHFTEYRIDIHACNHAAH-------------------TVGCSAATFVFARTMPHREADGIPGKVAWKAAGKSSVTLHWLEPPDPNGLILKYEIKYRRLGEEA-----TVLCVSR-------------------LRYAKVGGVHLALLPPGNYSAKVRATSLAGNGSWTDGVTFYITDLEEEDTGGMRIFLTVTPVGFMLLVTLAALGFFYSRKR--NSTLYTSVNPEYFSASHMYVPDEWEVPREQIAIIR---ELGQGSFGMVYEGLARGLEA----------GEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLG 1047          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  +LR    E E      Q  L      A +IADGM YL+  KFVHRDLAARNCM++    +KIGDFGM RDVY   YYRK  KG LPVRWMAPESL  G F+  SD+WS+GV+LWEI+TLA  PY+G+S+  V+++V  GG L      N    L  +M  CW ++P  RP+F  I+ +++     +FR  S+Y
Sbjct: 1056 LVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELE--NCPIQLQELMRLCWQHSPRLRPTFVHILDRIQDELRPSFRLCSFY 1260          

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIA-MVTLTSE----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCP-----RGENLQK---------YCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGC-YGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKK-YCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVE-----GYIGKP-VVIDNLLPAKRYAFYAEAI----RSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQ-----FLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKK--MVQVPANETYFK------------FTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISS-DSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +VC S+DIR   + +  L NC+V+EG L I  M   T E     SFP L ++T  L+++ V G ++L   FPNLT+IRG  L   YA++I E  +L  +GL +L  V+ G VR++ N  LC+++TI+W  +     AP     + N   E C + CP      GE   +          CW  + CQ VC   C +        D   CCH ECLGGC   E    CV+C+++   G C++ C    Y+Y++ RC++   C +L             + I + +C+ QC PG  +N  +  C  C   C K+   G   I S+    +  GC  +E   I     G +L   L +    +  I   L+I  S ++ +L F ++L++I             +  + +    V DN+NL ++     A     +TI  G + F  N +LC E I   L     T+ + SK +  I   +NGD A C+   L   V N+++    +    +   +  ++     ++  +   +N +++   ++C  Q+W  ++         +P V +  L P  +YA +  AI         +    S ++YL T    P+ P ++ + + SSS + + W PP+  NG +T Y++ ++ L   G D ++ D C    +          +R          QG C C    +     Q L  ++  +   Q     FL   IT        IPK+ WK                               +++I+K    +   H ++  ++++  N + F+             + L H+TEY  +I AC    +                    + CS+ + + A T P    D I           SSV + W EP  PNG IL Y I+YR+   EA     +  CV+R                   +   K G   L  L PG Y  +++  ++A  G+WT    F I+  +   T     F+    V  ++L  L  L  +Y +K+    T + S NP+Y+    +Y  D WE+ R+ + ++     LG+GSFGMVY+G+ + L             E+   VA+KT+N  ++  ER EF+ EA  MK F+ +H+V+L G
Sbjct:   28 EVCPSLDIRSEVTELRRLENCSVVEGHLQILLMFAATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLTVIRGTRLFLGYALIIFEMPHLRDVGLPSLGAVLRGAVRVEKNQELCHLSTIDWGLL---QPAPGTNHIVGNKLGEECADVCPGVLGAAGEPCSRTTFSGRTDYRCWTSSHCQKVC--PCPRGMACTAGGD---CCHSECLGGCSQPEDPRACVACRHLYFQGVCLRACPPGTYQYESWRCVTAELCAHLREVPGL----ATTFGIYEGSCLAQCPPGFTRNGSSIFCHKCEGLCPKECKVGTKTIDSVQATQDLVGCTHVEGNLILNLRQGYNLEPELQRNLGLVETITGFLKIKHSFALVTLGFFKNLKLI----------RGDSMVDGNYTLYVLDNQNLQQLGSWVTA----GLTIPVGKIYFAFNPRLCLEHIYQ-LEEVTGTRGRQSKAE--INPRTNGDRAACQTRTLRF-VFNLTEEDRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLAPLKPWTQYAVFVRAITLTTAEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPVQRNGNITYYLVLWQRLAEDG-DLYINDYCHRGLRLPTSSHDTRFDREDPALEAEPEQGCCPC----QHSPPGQALPALEAQEVTFQKKFENFLHHAIT--------IPKAPWK-------------------------------VTSINKNPQRDSERHRREAGLLRLGKNNSDFEIQEDKVPRERAILSGLRHFTEYRIDIHACNHAAH-------------------TVGCSAATFVFARTMPHREADGIPGKVAWKAAGKSSVTLHWLEPPDPNGLILKYEIKYRRLGEEA-----TVLCVSR-------------------LRYAKVGGVHLALLPPGNYSAKVRATSLAGNGSWTDGVTFYITDLEEEDTGGMRIFLTVTPVGFMLLVTLAALGFFYSRKR--NSTLYTSVNPEYFSASHMYVPDEWEVPREQIAIIR---ELGQGSFGMVYEGLARGLEA----------GEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLG 1047          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  +LR    E E      Q  L      A +IADGM YL+  KFVHRDLAARNCM++    +KIGDFGM RDVY   YYRK  KG LPVRWMAPESL  G F+  SD+WS+GV+LWEI+TLA  PY+G+S+  V+++V  GG L      N    L  +M  CW ++P  RP+F  I+ +++     +FR  S+Y
Sbjct: 1056 LVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELE--NCPIQLQELMRLCWQHSPRLRPTFVHILDRIQDELRPSFRLCSFY 1260          

Query:  156 IFNIINLYQAITFTDSFKLSNEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSEYS---FPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINM-RNFCLEFCPNNCPRGENLQK---------YCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDE-MCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCG-----RVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTVEGYI-----GKP-VVIDNLLPAKRYAFYAEAIR-SRVEN---WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYR 2060
            ++ ++ L  A++    +  S E     IDIR     +  L NCTVIEG L+I +++   +Y    FP L  IT  L+++ V G ++LG  FPNLT+IRG  L YNYA+VI E TNL  IGL NLR +  G +RI+ N  LCY++TI+W+ I+        + N     C + CP         +K          CW  N CQ +C   C K  + C  N  N CCHPECLG C+   D   CV+C++    G CV  C    Y+++  RC+    C N+ +  S+D    D + I DD C+++C  G  +N      C  C   C  K CG        I S+      +GC  ++ ++ I+I+ G +  S+ L      + ++   ++I  S ++ SL FL++LR+I G    + N            F V DN+NL +++D     N  N+T+  G + F  N KLC  +I   +     TK + SK D  I   +NG+ A C+ + L         +   +  H   P       + T  +  KE   KNV++Y+  ++C   +W  V+  +     G+P +++  L P  +YA Y +A+  + VEN       S+++Y+ T    PS P+++ + + SSS++ + WNPP  PNG ++ YI+ W R
Sbjct:   13 LWGLVFLSAALSL---WPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGK--RACTEN--NECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSD---SDGFVIHDDECMQECPSGFIRNSTQSMYCIPCEGPCP-KVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASE-LENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYS----------FYVLDNQNLQQLWD----WNHRNLTVRSGKMYFAFNPKLCVSEIYR-MEEVTGTKGRQSKGD--INTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYY--KEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQR 651          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEG----FVSENQSHL--WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    E E      +  + S +   A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI TLA  PY+G+S+  V+++V +GG L      N   +L  +M  CW YNP  RPSF +II  ++   + +F+  S+Y
Sbjct: 1077 LVIMELMTRGDLKSYLRSLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEMEPSFQEVSFY 1282          

Query: 2526 FTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLER----TRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
             +NL  +T Y  +I +C       + E++ L             CS+ + + A T P E  D+I           +S+ + W EP++PNG IL Y I+Y     +         CV+R E+                   +K G   L  L PG Y  +I+  +++  G+WT    F + + + +  + +  I   V I++I+  L +++  + +K+   R      + S NP+Y+    +Y  D WE+ R+ + M   N  LG+GSFGMVY+GV K +            DE +  VA+KT+N  +++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:  791 ISNLRPFTLYRIDIHSC-------NHEAEKLG------------CSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQR------ECVSRQEY-------------------RKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITM---NRELGQGSFGMVYEGVAKGVVK----------DEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLG 1068          

Query: 3762 VIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL----WAIQIADGMLYLSEMKFVHRDLAARNCMIN-----SLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSY 4361
            +I+ELME GDL  YLRK    G  F   + + L      + I+ G +YL +M F+HRDLAARNC+++     S  ++KIGDFG+AR++Y + YYRK  +G LPVRWMAPE+L+ G F+  SD+WS+G+++WEILTL   PY   S+ DV+ YV  GG L      N    L  +M  CW   PD RP+F +I  +L+L+ ++   N S+
Sbjct: 1996 IILELMEGGDLLSYLRKA--RGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRL--EPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNVSH 2200          

Query:  225 VCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTS----EYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGC-YGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRRE-DHYAIEDDACVKQCSPG-----KQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNS---CSEQNWRTVEGYIGKPVVID------NLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFI--KQNEIPKSNWKPVDSGHF-EIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVN---GSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKI--SSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYW---IIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            VC S+DIR    +  LL NCTVIEG L I++  L +      SFP L+EIT  L++Y V G +TL   FPNL IIRG+ L  +YA+V+ E  +L  +GLVNLR +  GGVR+  N  LCY+ TINWT I        + IN +    E CPN+C + E   K CW ++ CQ   +  C K N YC  N    CCH  CLGGC      + C SCK V  N  C  +C    YK+ NRRC+++ EC+ L++    +  +  D    E   C+  C         + NK   +C  C   C K+ C  + I++I D  + + C  I          GS+++  L K+   +  +  ++ I +S ++ +L F ++L+II     +    E  +         + DN NL E+F E+       + IL G +  + N +LCP  I  FL     +   LS+    I ++SNG    C+   L V V  I+ ++  +  +    D   +   LT +   KE     +   +F     CS   W T E    +    D      +L P   YA Y +A          +++++  TT   +PS+P +L   +    E+R++W PP +PNG +T Y I Y  LE+    +   + C      Q++ +        K  N + N   C C K  E  +         +   I  + ++Y+ K     + +++P       D  +  ++ ++ YN +   D +   FP+  I   S   + NLT   K++V     E      NL H++EY  E+ ACQD                 ++ VL+  CS +++    T      D INE+T++T +      +V I W  P SPNG IL Y + Y+K   E  +    T C+TR E+L                   K+  Y L  L+PG + F+I   ++A   ++T    F +    D   +       I      ++  +L V   YY +K   +    +S N +Y    I+Y  D WE+DR  + +++    LG+GSFGMVY+GV K          +R    +++ VAVKT+N  ++  +RREF+ EA  MK+F  +H+VKL G
Sbjct:   64 VCGSVDIRSSMDNFKLLENCTVIEGSLRISLFELKALDFRHLSFPDLREITDYLLMYRVYGLETLSKLFPNLAIIRGRELFNSYAIVMYEMRDLQDLGLVNLRTISRGGVRLTKNFKLCYIETINWTQIGVSDPEARRFINNK----EQCPNSC-KDECQSKRCWTYSDCQKGLNCQC-KENTYCMEN--GSCCHDYCLGGCKVPMNPDECFSCKEVQFNNTCRPQCPPGTYKFLNRRCLTDKECLALTNDPDGNTPKLLDGEKGEPSLCLYTCPQNYSVGDSKDNKNLSQCVKCRQLCPKE-CHGLEINNIQDAHKLKECSKISGPLKIQIMSGSNVAQELEKSLGNIREVTETIHIKRSYALVTLHFFKNLQIIGSKVPSSETQEGQS-----FSLFLMDNTNLQELFPEE---QMKKMKILNGGIYVHDNGQLCPHTIKEFL-----SHLNLSEAQSSISSISNGHQRPCEKHDLNVTVEKIAHNAAILAWNKYKAD---ERQLLTYILNYKEIKDESNDINIFQGRDLCSHDLWMTREYAPKEGPEADQIGMLYDLKPFTTYAVYIQAYTVSTATHAAMTNILTFTTYPFHPSEPTDLVAISEDPHELRVSWKPPKYPNGNITHYKIVYHKLELNEKSYEQRNYCRDPLVHQKKKEKVKIEEEGKKINNSANSNCCKCPKSKEEMDTES------RKREIEMYFEDYLHKHIYCKRYDKLPDEVDLNFDGMNLPQLVEMNYNSSETSDRIEV-FPNYVIENTS--DLANLTEIVKEVVVYGTTEV--TLPNLEHFSEYSIEVLACQDY----------------NEKVLSKLCSIRAITFERTKDSYAADMINETTVDTEIETNFTGNVFIKWESPTSPNGLILKYLLWYKKANQENLVP--QTICITRQEYL-------------------KNLGYKLTRLEPGNWTFKISAISLAENSSFTLERFFIVPRPPDPESSNTLLIVAIVLAFFGVLTVSLIVACVYYKQKIRSDDMTVISRNMNYVPSEILYISDEWEVDRDKIKLIK---ELGQGSFGMVYEGVAKG---------IRDDPNEEIPVAVKTVNDRASFSDRREFLKEATTMKEFHCHHVVKLLG 1106          

Query: 3759 LVIMELMEFGDLAGYLR--KQGEEGEGFVSENQSHLWAI-----QIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR  +  E+  G +     HL  I     +IADGM YL++ KFVHRDLAARNCM++    +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+  SD+WSYGV++WE++TLA+ PY+G+S+ +V++++S G   +     N    +  +M++CW   P+ RP+F  II+ L      +F   SY+
Sbjct: 1115 LVIMELMALGDLKNYLRGHRPDEDHPGVMP---PHLLDILQMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTVKIGDFGMTRDIYETDYYRKGGKGMLPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLSNEEVVKFISDG--YIMELPENCPNEMAYLMQHCWAKKPNQRPTFKAIIEYLLPKLKPSFEKVSYF 1318          

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTS-----EYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRN--FCLEFCPN------NCP----RGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDH-YAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYC----GRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPV-------------VIDNLLPAKRYAFYAEAIRS---RVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNK--NQILINIDKDDTIMQFLDEYITKSFIKQN-------EIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTR---------WVSSNPDYW--------IIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +VC  +DIR   + +  L NC+VIEG L I ++  T      + SFP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  +GL NL  +  G VRI+ N  LCY+ TI+W+ I+        ++N  +   C + CP       NCP     G+ +++ CW H+ CQ VC   C  +   C       CCH ECLG C    D   CV+C+N   +GRCV+ C   +Y +++ RC++ S C +L  +     R+  H Y I ++ C+ +C  G   N     C  C   C K  C    G   I S+    E  GC  I    I    GG++L+  L      +  I   L+I +S ++ SL F R LR+I+G +    N            F   DN+NL +++D     ++ N+TI +G + F+ N KLC  +I   +     TK +  + D  I   +NGD A C++E L    +  S     ++     P    ++     LF  +   +NV++++  ++C   +W  V+  I  P+             ++  L P  +YA + + + +       +   SD+IY+ T+  NPS P++  + + SSS+I L W PP  PNG +T Y++ W R  E    + F  D C  K                 +   NQ++ E    +C  SC K  +QIL  +++      F D      F+ +        E P+ + K    G         N TV V  V   FP+T  S+ S P+       F+K+V    N+     + L H+T Y  E+QAC    N  + E +               CS  + +SA T P+   D+I     +     + V + W EPK PNG I+ Y + YR+Y  E EL      CV+R  +                          LR L PG Y  +I+  ++A  G+WT+  +F +      T+Y +     A +II  L  +F+            R R         + SSNP+Y          +Y  D WE+ R+ + +L     LG+GSFGMVY+G  +++             E +  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   33 EVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVER-CWTHSHCQKVCPTICKSHG--CTAE--GLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK-VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYS----------FYALDNQNLRQLWD----WSKHNLTITQGKLFFHYNPKLCLSEIHK-MEEVSGTKGRQERND--IALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPP-DFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD--IDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAE--DSELFELDYCL-KGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECC-SCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVG------NVTVAVPTVAA-FPNT--SSTSVPTSPEEHRPFEKVV----NKESLVISGLRHFTGYRIELQAC----NQDTPEER---------------CSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDE-ELHL----CVSRKHFALERGC-------------------RLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYV------TDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLR---ELGQGSFGMVYEGNARDIIK----------GEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLG 1091          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  YLR    E E         L      A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+ SSD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GG L      N  + +  +M  CW +NP  RP+F +I+  L+     +F   S++
Sbjct: 1100 LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPD--NCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF 1304          

Query:  156 IFNIINLYQAITFTDSFKLSNEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSEYS---FPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINM-RNFCLEFCPNNCPRGENLQK---------YCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDE-MCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCG-----RVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTVEGYI-----GKP-VVIDNLLPAKRYAFYAEAIR-SRVEN---WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLE---IFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGE-CDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISK--PSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLER----TRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            ++ ++ L  A++    +  S E     IDIR     +  L NCTVIEG L+I +++   +Y    FP L  IT  L+++ V G ++LG  FPNLT+IRG  L YNYA+VI E TNL  IGL NLR +  G +RI+ N  LCY++TI+W+ I+        + N     C + CP         +K          CW  N CQ +C   C K  + C  N  N CCHPECLG C+   D   CV+C++    G CV  C    Y+++  RC+    C N+ +  S+D    D + I D  C+++C  G  +N      C  C   C  K CG        I S+      +GC  ++ ++ I+I+ G +  S+ L      + ++   ++I  S ++ SL FL++LR+I G    + N            F V DN+NL +++D     N  N+T+  G + F  N KLC  +I   +     TK + SK D  I   +NG+ A C+ + L         +   +  H   P       + T  +  KE   KNV++Y+  ++C   +W  V+  +     G+P +++  L P  +YA Y +A+  + VEN       S+++Y+ T    PS P+++ + + SSS++ + WNPP  PNG ++ YI+ W R  +   +F  ++  +D    +  +   I  +      KT     ++G  C C K        +      K        + ++  S      +P+   +  D    ++     +   R   V   +  TD        P  E+  ++ ++ V           +NL  +T Y  +I +C       + E++ L             CS+ + + A T P E  D+I           +S+ + W EP++PNG IL Y I+Y     +         CV+R E+                   +K G   L  L PG Y  +I+  +++  G+WT    F + + + +  + +  I   V I++I+  L +++  + +K+   R      + S NP+Y+    +Y  D WE+ R+ + M   N  LG+GSFGMVY+GV K +            DE +  VA+KT+N  +++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   13 LWGLVFLSAALSL---WPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGK--RACTEN--NECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSD---SDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCP-KVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASE-LENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYS----------FYVLDNQNLQQLWD----WNHRNLTVRSGKMYFAFNPKLCVSEIYR-MEEVTGTKGRQSKGD--INTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYY--KEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRK------VFENFLHNSIF----VPRPERRRRDV--LQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTV----------ISNLRPFTLYRIDIHSC-------NHEAEKLG------------CSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQR------ECVSRQEY-------------------RKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITM---NRELGQGSFGMVYEGVAKGVVK----------DEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLG 1068          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEG---FVSENQSHL--WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    E E     +  + S +   A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI TLA  PY+G+S+  V+++V +GG L      N   +L  +M  CW YNP  RPSF +II  ++   + +F+  S+Y
Sbjct: 1077 LVIMELMTRGDLKSYLRSLRPEVENNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEMEPSFQEVSFY 1281          

Query:  183 AITFTDSFKLSNEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTS-----EYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRN--FCLEFCPN------NCP----RGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDH-YAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYC----GRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPV---------------VIDNLLPAKRYAFYAEAI---RSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCN----KNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTR---------WVSSNPDYW--------IIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            A+    +  L   +VC  +DIR   + +  L NC+VIEG L I ++  T      + SFP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  +GL NL  +  G VRI+ N  LCY+ TI+W+ I+        ++N  +   C + CP       NCP     G+ +++ CW H+ CQ VC   C  +   C       CCH ECLG C    D   CV+C+N   +G+CV+ C   +Y +++ RC++ S C +L  +     +   H Y I ++ C+ +C  G   N     C  C   C K  C    G   I S+    E  GC  I    I    GG++L+  L      +  I   L+I +S ++ SL F R L +I+G +    N            F   DN+NL +++D     N+ N+TI +G + F+ N KLC  +I   +     TK +  + D  I   +NGD A C++E L    +  S     ++     P    ++     LF  +   +NV++++  ++C   +W  V+  I  P                ++  L P  +YA + + +         +   SD+IY+ T+  NPS P++  + + SSS+I L W PP  PNG +T Y++ W R  E    + F  D C    K  +      +      ++   NQ E D D   E C+     +QIL  +++      F D      F+ +     +  +            E          + +FP  +IS+   P+       F+K+V    N+     + L H+T Y  E+QAC    N  S E ++                  + +SA T P+   D+I     +     + V + W EPK PNG I+ Y + YR+Y  E EL      CV+R  +                          LR L PG Y  +++  ++A  G+WT+  +F +      T+Y +     A +II  L  +F+            R R         + SSNP+Y          +Y  D WE+ R+ + +L     LG+GSFGMVY+G  K++             E +  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   19 AVAGGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDYVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVER-CWTHSHCQKVCPTICKSHG--CTAE--GLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHYKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPK-VCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYS----------FYALDNQNLRQLWD----WNKHNLTITQGKLFFHYNPKLCLSEIHK-MEEVSGTKGRQERND--IALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPP-DFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD--IDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAE--DSELFELDYCL---KGLKLPSRTWSPPFESDDSQKHNQSEYD-DSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDTRPSRKRRSLEEVGNVTATTPTLPDFP--NISSTIAPTSHEEHRPFEKVV----NKESLVISGLRHFTGYRIELQAC----NQDSPEERS---------------GVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDE-ELHL----CVSRKHFALERGC-------------------RLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYV------TDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLR---ELGQGSFGMVYEGNAKDIIK----------GEVETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLG 1092          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAI-----QIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  +LR    + E         L  +     +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+ SSD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GG L      N  + L  +M  CW +NP  RP+F +I+  L+     +F   S++
Sbjct: 1101 LVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPD--NCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF 1305          

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTS-----EYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRN--FCLEFCPN------NCP----RGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDH-YAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYC----GRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPV---------------VIDNLLPAKRYAFYAEAIRS---RVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCN----KNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTR---------WVSSNPDYW--------IIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +VC  +DIR   + +  L NC+VIEG L I ++  T      + SFP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+VI E  +L  +GL NL  +  G VRI+ N  LCY+ TI+W+ I+        ++N  +   C + CP       NCP     G+ +++ CW H+ CQ VC   C  +   C       CCH ECLG C    D   CV+C+N   +G+CV+ C   +Y +++ RC++ S C +L  +     +   H Y I ++ C+ +C  G   N     C  C   C K  C    G   I S+    E  GC  I    I    GG++L+  L      +  I   L+I +S ++ SL F R L +I+G +    N            F   DN+NL +++D     ++ N+TI +G + F+ N KLC  +I   +     TK +  + D  I   +NGD A C++E L    +  S     ++     P    ++     LF  +   +NV++++  ++C   +W  V+  I  P                ++  L P  +YA + + + +       +   SD+IY+ T+  NPS P++  + + SSS+I L W PP  PNG +T Y++ W R  E    + F  D C    K  +      +      ++   NQ E D D   E C+     +QIL  +++      F D      F+ +   P    + ++         E          + +FP  ++S+   P+ +     F+K+V    N+     + L H+T Y  E+QAC    N  S + +               CS  + +SA T P+   D+I     +     + V + W EPK PNG I+ Y + YR+Y  E EL      CV+R  +                          LR L PG Y  +++  ++A  G+WT+  +F +      T+Y +     A +II  L  +F+            R R         + SSNP+Y          +Y  D WE+ R+ + +L     LG+GSFGMVY+G  K++             E +  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   33 EVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVER-CWTHSHCQKVCPTICKSHG--CTAE--GLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPK-VCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYS----------FYALDNQNLRQLWD----WSKHNLTITQGKLFFHYNPKLCLSEIHK-MEEVSGTKGRQERND--IALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPP-DFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVD--IDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAE--DSELFELDYCL---KGLKLPSRTWSPPFESDDSQKHNQSEYD-DSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPR---PSRKRRSLE---------EVGNVTATTLTLPDFP--NVSSTIVPTSQEEHRPFEKVV----NKESLVISGLRHFTGYRIELQAC----NQDSPDER---------------CSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDE-ELHL----CVSRKHFALERGC-------------------RLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYV------TDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLR---ELGQGSFGMVYEGNAKDIIK----------GEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLG 1081          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAI-----QIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  +LR    + E         L  +     +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+ SSD+WS+GV+LWEI +LA  PY+G+S+  V+++V  GG L      N  + L  +M  CW +NP  RP+F +I+  L+     +F   S++
Sbjct: 1090 LVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPD--NCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF 1294          

Query:  312 MVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLL------YIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYXXXXXXXXXXXXXXLLATRLESENSTKNFIQDS 4463
            MVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLL      YIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTN P+TDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNI+AKNSSNSTNI QQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYFQKQQTDFQTQEQDLLATRLESENST NFIQDS
Sbjct:    1 MVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLVINLFQYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNLPATDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIMAKNSSNSTNIIQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYFQKQQTDFQTQEQDLLATRLESENSTNNFIQDS 1390          

Query:  219 EKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEF-----------CPNNC----------PRGENL--QKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESEC-------MNLSSQSSTDY------------RREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEG-GSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFD--------EKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNV-----QTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPD-ISLQNSALTALFMLKETTKNVSQ----YELFNSCS--------------EQNWRTVEGY----------------IGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPK--SNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPS-----IENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALS---------KNGTSKNVLNLP----------CSSKSLISAHTSPKENMDNINESTINTRVNG-SSVKIFWSEPKSPNGFILNYFIRYRKYPY------------EAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQK---------------SGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKIS-----SDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRRKFKCFGH--SVMSRVKCPLNWNSLNRINILK-------LFDSKASEIKERQIDD--IAAAQFG------------SFKATISQHFDKM----PLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGS-FNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLE-LYADMNFRNNSYY 4364
            E  C   D+R  S ++ L+ CTVIEGDL+I    +  + S P LKE+TGSL++Y  +G + L +  PNLT++RGQTL + Y+VVIK T+   IGL +LR++  GGVRID+NP LCYV TI+W  I++     +  I +    L              PNN           P  + L    +CW  N CQ++C   C   N  C M  P +CCHPECL GCYG+G   CV+CKNV+ + +C+ KC    +KY NRRC++E +C       M   S   ++Y            R   ++ I + +C+ +C  G +++  TG C  CG +C  K+C   LI+++       GCYS + IY+SI++G   +++++L +AF  L +I +SLRIV+SS + +L+FL+ +  I             N S+  IVFE++ N+NL  ++         E   +N L I +  G +    NR+LCPEKI     SN+          L++ +  +I ++NGD+A+C   +  V V N   SS +V+     P  I   N ++   F     + +V +    Y  + S                + +WR +                   +   + +  L  A RYA Y E ++  ++    +S+++Y TT   NP+ P     E L+ + +RLTW PP+ P+G +  Y+IW R LE    ++  +D C                    T+  N  Q   D +   +  +  QI ++ D  D+ +   +    +       IP    N+ P     +          V VDEVV+    T    + K +     I +    ++K      NE     T    +T    EIQAC    ++   ES+            K+GT+  +  L           CS +S +    +P    D +  ++I+  +NG  S++I WS P  PNG IL+Y +RYR   +            +  L WL T C++   W    +  A  SS+   INQ++                G  +++DL PG YEFQI   ++A  G W+ +  F I      + +I  +   Y  I      ++LC +  ++ Y  ++ Y + T W S+NPDY  IYE+D WEI++ DVD+L W YP+GRGS G VYKGV+K L TPA+  Y   ++   + VA+KT++ +ST+ + R+FINEAC+MKQFQSYHLV+L G+V+K      S      KF    H   +   +   L W S +  +          L  S +S I ++ +DD  +    FG             F  T S  F+K+    PLVIM+LM  GDLA YLR  G++G+G V+ +Q++LWA QIADGM YLS  ++VHRDLAARNC+++S L +KIGDFG+ RDVY   YY K + G+ P+RWMAPESL + YF+  SD+WSYGV+LWEI+T+A LPY GMSH +V++Y+  G +LLS G+  N  +LL  +M +CW ++P  RP+F  +   L   + D  FR  S++
Sbjct:   18 EVACTRADVRHSSSLTKLSRCTVIEGDLFIVFTRIPRDASLPFLKEVTGSLLVYDTEGPEDLSILLPNLTLVRGQTLVFGYSVVIKSTSFKSIGLPSLRVIQQGGVRIDSNPQLCYVETIDWKVILQNQSGDVSSIKIVKNGLICSNICSSSCSVNSPNNTQHSSVELWRSPFSDILPTDGHCWSMNECQSICPVYCTLQNLTCTMKRPYKCCHPECLAGCYGDGPSECVACKNVMHDNQCISKCPSGTFKYLNRRCVTEYQCLVELPNMMYSDSPYISEYYANNSFPYNDMTRMHSNFTIFNGSCLLKCPVGYKKSLKTGHCYACGDQCELKHCREFLIYNLKALDTLTGCYSAKAIYLSIQDGKPETVANLLDRAFKNLKVIHHSLRIVRSSVLENLNFLQHVHSI--------GQIGENVSSHPIVFELFGNDNLRNLWPIAKDANNIEDDPVNSLQI-LSNGLIRITQNRQLCPEKIFQLFESNIIKSSGNNNITLTQAEREMITITNGDLAYCNWREFNVTVSN--RSSHSVRVTWPHPSTIHFTNKSVNTNFSDGSNSSHVDEVVLIYLFYQSAPNDLPDIIKGRRVYDKNSWRMLTTSCDLNPGDSISSFSYLELDCGLTLSELEAATRYAIYVE-MKFPLKQTGAVSNLVYFTTLSVNPTPPQYPWLEPLNQNSLRLTWMPPVKPSGIIDAYLIWIRILEDNPSEYLTQDFC--------------------THRPNWIQSGWDKNSLFK--HSRQINLHNDYCDSCLPCPNLLEIEQLSNTQAIPSLDKNYWPPSVSRWMTDNFGNILPVIVDEVVSLKSDTVGLIVQKNASTFQHISHFQMDYEKKCIHSVNENVKYLTGFPPFTRVLVEIQACLSYDSISYVESETKCHRPPPWSNLKSGTTIYLHQLHHQWSVCEYELCSPRSTVINRVNPHVESDKVPVASIHATLNGPGSIRITWSNPIKPNGLILHYLLRYRPRNHDQSYTDSNHSSSDVSLPWL-TKCISMSHWSADHSEHALTSSSYITINQKEVSRSKRGYNANSSTTDGGISIKDLSPGSYEFQILAVSLAGNGEWSPTVIFNIPFYTDHNGTINRQKLVYISIIIASSFLLLCFILAIIWYKARRYYFKATAWTSNNPDYCTIYEVDNWEINKDDVDVLHWKYPIGRGSLGTVYKGVVKQLKTPAKLLYNNPVN---IPVAIKTISVHSTLFDHRDFINEACFMKQFQSYHLVRLLGLVTKTKIKHKSVTDNCIKFLHHHHFGKLCQFISGILPWTSTSVSSSSPNVKLHPLLSPSISSPIGKQMLDDDEVNCHTFGLSKNFTPVDDASLFNNTKSFGFNKVAPDSPLVIMQLMAKGDLASYLRYLGDKGQGTVNSSQAYLWATQIADGMAYLSAKQYVHRDLAARNCLVDSHLTVKIGDFGLCRDVYGRNYYHKTSHGKPPIRWMAPESLQTAYFTTQSDVWSYGVVLWEIVTMACLPYCGMSHEEVVRYILSGKTLLSNGTPTNCPELLRALMLHCWNFDPLKRPTFLGLCALLSPCFGDAKFRLASFF 1540          

Query:  165 IINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEF-----------CPNNC----------PRGENL--QKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESEC-------MNLSSQSSTDY------------RREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEG-GSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFD--------EKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNV-----QTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPD-ISLQNSALTALFMLKETTKNVSQ----YELFNSCS--------------EQNWRTVEGY----------------IGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECD-CDKC-----MESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPS-----IENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALS---------KNGTSKNVLNLP----------CSSKSLISAHTSPKENMDNINESTINTRVNG-SSVKIFWSEPKSPNGFILNYFIRYRKYPY------------EAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQK---------------SGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKIS-----SDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRRKFKCFGH--SVMSRVKCPLNWNSLNRINILK-------LFDSKASEIKERQIDD--IAAAQFG------------SFKATISQHFDKM----PLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLL 4250
            ++N+      TD    S E  C   D+R  S ++ L+ CTVIEGDL+I    +  + S P LKE+TGSL++Y  +G + L +  PNLT++RGQTL + Y+VVIK T+   IGL +LR++  GGVRID+NP LCYV TI+W  I++     +  I +    L              PNN           P  + L    +CW  N CQ++C   C   N  C M  P +CCHPECL GCYG+G   CV+CKNV+ + +C+ KC    +KY NRRC++E +C       M   S   ++Y            R   ++ I + +C+ +C  G +++  TG C  CG +C  K+C   LI+++       GCYS + IY+SI++G   +++++L +AF  L +I +SLRIV+SS + +L+FL+ +  I             N S+  IVFE++ N+NL  ++         E   +N L I +  G +    NR+LCPEKI     SN+          L++ +  +I ++NGD+A+C   +  V V N   SS +V+     P  I   N ++   F     + +V +    Y  + S                + +WR +                   +   + +  L  A RYA Y E ++  ++    +S+++Y TT   NP+ P     E L+ + +RLTW PP+ P+G +  Y+IW R LE    ++  +D C T   +  +     N+    +   N +   CD C  C     +E  +  Q + ++DK +     +  ++T +F         N  PV               + VDE+V+    T    + K +     I +    ++K      NE     T    +T    EIQAC    ++   ESK            K+GT+ ++  L           CS +S +    +P    D +  ++I+  +NG  S++I WS P  PNG IL+Y +RYR   +            +  L WL T C++   W    +  A  SS+   INQ++                G  +++DL PG YEFQI   ++A  G W+ +  F I      + +I  +   Y  I      ++LC +  ++ Y  ++ Y + T W S+NPDY  IYE+D WEI++ DVD+L W YP+GRGSFG VYKGV+K L TPA+  Y   ++   + VA+KT++ +ST+ + R+FINEAC+MKQFQSYHLV+L G+V+K      S      KF    H   +   +   L W S +  +          L  S +S I ++ +DD  +    FG             F  T S  F+K+    PLVIM+LM  GDLA YLR  G++G+G V+ +Q++LWA QIADGM YLS  ++VHRDLAARNC+++S L +KIGDFG+ RDVY   YY K + G+LP+RWMAPESL + YF+  SD+WSYGV+LWEI+T+A LPY GMSH +V++Y+  G +LLS G+  +   LL
Sbjct:    1 MLNILAQHDSTD-LGFSQEVACTRADVRHSSSLTKLSRCTVIEGDLFIVFTRIPRDASLPFLKEVTGSLLVYDTEGPEDLSILLPNLTLVRGQTLVFGYSVVIKSTSFKSIGLPSLRVIQQGGVRIDSNPQLCYVETIDWKVILQNQSGDVSSIKIVKNGLICSNICSSSCSVNSPNNTQHSSVELWRSPFSDILPTDGHCWSMNECQSICPVYCTLQNLTCTMKRPYKCCHPECLAGCYGDGPSECVACKNVMHDNQCISKCPSGTFKYLNRRCVTEYQCLVELPNMMYSDSPYISEYYANNSFPYNDMTRMHSNFTIFNGSCLLKCPVGYKKSLKTGHCYACGDQCELKHCREFLIYNLKALDTLTGCYSAKAIYLSIQDGKPETVANLLDRAFKNLKVIHHSLRIVRSSVLENLNFLQHVHSI--------GQIGENVSSHPIVFELFGNDNLRNLWPIAKDANNIEDDPVNSLQI-LSNGLIRITQNRQLCPEKIFQLFESNIIKSSGNNNITLTQAEREMITITNGDLAYCNWSEFNVTVSN--RSSHSVRVTWPHPSTIHFTNKSVNTNFSDGSNSSHVDEVVLIYLFYQSAPNDLPDIIKGRRVYDKNSWRMLTTSCDLNPGDSISSFSYLELDCGLTLSELEAATRYAIYVE-MKFPLKQTGAVSNLVYFTTLSVNPTPPQYPWLEPLNQNSLRLTWMPPVKPSGIIDAYLIWIRILEDNPSEYLTQDFC-THRPNWIQSGWDKNSLFKHSRQINLHNDYCDSCLSCPNLLEIEQLSNTQAIPSLDK-NYWPSSVSRWMTDNF--------GNILPV---------------IVVDEIVSLKSDTVGLIVQKNASTFQHISHFQMDYEKKCIHSVNENVKYLTGFPPFTRVLVEIQACLSYDSISYVESKTKCHRPPPWSNLKSGTTISLHQLHHKWSVCEYELCSPRSTVINRVNPHVESDKVPVASIHATLNGPGSIRITWSNPIKPNGLILHYLLRYRPRNHDQSYTDSNHSSSDVSLPWL-TKCISMSHWSADHSEHALTSSSYIAINQKEVSRSKRGYNANSSTTDGGISIKDLSPGSYEFQILAVSLAGNGEWSPTVIFNIPFYTDHNGTINRQKLVYISIIIASSFLLLCFILAIIWYKARRYYFKATAWTSNNPDYCTIYEVDNWEINKDDVDVLHWKYPIGRGSFGTVYKGVVKQLKTPAKLLYNNPVN---IPVAIKTISVHSTLFDHRDFINEACFMKQFQSYHLVRLLGLVTKTKIKHKSVTDNCIKFLHHHHFGKLCQFISGILPWTSTSVSSSSPNVKPHPLLSPSISSPIGKQMLDDDEVNCHTFGLSKNFTPVDDASLFNNTKSFGFNKVAPDSPLVIMQLMAKGDLASYLRYLGDKGQGTVNSSQAYLWATQIADGMAYLSAKQYVHRDLAARNCLVDSHLTVKIGDFGLCRDVYGRNYYHKTSHGKLPIRWMAPESLQTAYFTTQSDVWSYGVVLWEIVTMACLPYCGMSHEEVVRYILSGKTLLSNGTPTNCPELL 1501          

Query:  156 IFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSI--VRQHGAPIKLINMRNF-CLEFCPNNC---PRGENLQKY----------CWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECM---NLSSQSSTDYRRED--------------HYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSS-LSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQL--------NITILEGS-VSFNLNRKLCPEKILSFLNSN----VQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVK--------CHSKVPDISLQNSALTALFMLK----ETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVID--------NLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQG-ECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFK--FTNLHHYTEYFFEIQACQDLQNVQSSESKA-----------------LSKNGTS-KNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVN-GSSVKIFWSEPKSPNGFILNYFIRYRKYPY----------------------------------------EAELDWLSTPCVTRPEWL----NGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISS--DSIFTEYRNYXXXXXX----XXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEI-DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRRKFKC----------FGHSVMSR--------VKC--PLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLS-TGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKL-ELYADMNFRNNSYY 4364
            + ++++  +++  + ++     KVC+S+DIR+        NCTV+EGDL I+ + L+++ S P ++EITGSL+IY V G  +L    P L +IRGQ L   YA+V+K T L    L +LRL+  G VR+++NP LC+V+T+NW ++   R     I  +NM    C + CP  C   P      K+          CW  + CQ+VCS+ C ++N  C ++D  RCCHPECLGGCYG+G  MCVSC +VL    C+ +C +   +Y NRRC++  +C+    ++ +S + +   +              +YA+ +  CV+ C  G  ++ +TG+CE C   C +K C    IH++ D    + C+S + +Y+SI +  S   ++ L +AF+ L IIE+SLRIV+S++ITSL FL ++  I           +    + +I  EV +NENL  ++     L  +         + +   S V F  N +LCP  +    ++     +     LS+ ++ +I V+NG++ +C      +++  ++ SS  ++          + VP++ L    +T + + +    E   N+  +++     +++ R     +   V  D         L  A  Y+   E     + N L  S+ +  TT   NPS P      +     +RLTW  P  PNG ++ Y+IW R L     +F   D C  K         Q + R+ + +    N      C +C   C               + FL +      +  +++P   W       F + +         +E++  +       +    ++N+   F       A +T +     +L  +     E+ ACQ  Q  +S  + A                 +  N T   N     CS +  +      K + D I+ ++I+ + +  +SV+IFW EP  PN  +L Y IRYR   Y                                         A+  WL T C++   WL    NGT             +Q+  G   LR L  G Y FQI+ F++A  G W+  + F I +  D+   ++  + I+       ++ ++L      +  + +K+YL  T W S NP Y  IY++ D WEIDR ++D+L W +PLG GSFG VY+GV++ LTTPA   Y    D   + VA+KT+N  +T+ +  +FI+EAC+MKQF SYHLV L G+V++   ++     +  +F+           FG + +S         + C  P + +SL         DS    ++ RQI+    A                PLV+MELM  GDL  YLR  G+ G G V   Q++LWA QIADGM YL    +VHRDLAARNC +N+ LI+KIGDFG+ R+VY   YY K+  GRLP+RWMAPESL    F+  SD+WSYGV+LWE+ T+A LPYRGMSH  VI Y   G +L++ T   N   LLL +M  CW Y+P  RP+F  I   L   + D  FR++S+Y
Sbjct:    3 VLHLLSRTKSVGISSAYLTGFVKVCRSLDIRRPDIFKQSINCTVVEGDLIISFIRLSTDASLPYVREITGSLLIYDVHGLDSLAQLLPRLVLIRGQNLIDRYAMVLKSTGLKDAALPSLRLIHRGAVRLEDNPDLCHVHTVNWMALSGYRADAEHILKVNMNGASCADRCPAQCLSAPLTTGPAKFQQRTPYTNAPCWSSSICQSVCSDHCIEHNLACQVHDMERCCHPECLGGCYGDGPHMCVSCSHVLYGDSCISECPEGTLRYLNRRCVTVEQCLWSIPMAVRSDSPFNMSNSTEPAEYNGVPDWHNYAVFNQCCVENCPIGYIRHNVTGQCEPCDERCPRKRCPEFFIHTLKDLVALQDCWSAKAVYMSISDTDSDETAEALARAFATLRIIEHSLRIVRSTAITSLSFLNTVERI---------GSSVTEVDHTITLEVSENENLRTLWSPNGGLPHVINNSNDAAGLKVWSTSPVRFTQNSRLCPASVFRLFDTGALVLMPRGRSLSEAEQNLIRVTNGELVYCNLATFSLELSELTSSSVRIQWPQVTFQSSDTGVPNMPLHADVVTLMLLHQCHVLEDHSNLEDHDI-----DESIRCRMFQVSCAVYTDGKCYYQLSGLEAATSYSIRIEIRYPLLRNRL-YSERVQFTTATANPSAPRYAWLGSNGDDSLRLTWMNPSQPNGVISHYLIWVRLLSPQKVNFTSHDFCIKKPDWILSDLGQISFRVEQQSFSRTNLSISPTCRQCFSYCR-------------YLSFLSDVPNSEDLPSSDVP---WP------FSVSRWTLGDK---EELLPVYVVNSSGELDHSELDNVVGLFVISTNGGARDTEYTQYMRSLRPFRRVVVELSACQT-QTAKSVSNGACRAPAPWLGLHPGEFLDIELNRTHWSNCETQLCSPRVTMVGRMPSKGDADEIHATSISCQSSTPNSVEIFWREPDRPNDLVLYYVIRYRPTAYVLTSERTNSEKVENATTNQVSGSRCNTTIKLEELPDLSTTSAQTAWL-TKCISVGHWLAFQPNGT-------------HQRNVGGTFLRGLPSGSYLFQIQAFSLAGVGPWSPVHIFTIDAYLDTSLDQWSAHQILIVALNCSLVALLLTVGLTAIGCHLRKRYLRSTAWTSINPGYIDIYDVTDAWEIDRANIDVLSWKHPLGHGSFGTVYRGVVRCLTTPASTLY---PDSTNIPVAIKTINNTTTLFDHHDFISEACHMKQFHSYHLVCLLGLVTRTGKNERLPDQHCDRFRGLIRRIRLLAQFGQTSLSNQPFCHPDIIDCTDPTDQSSLGE-------DSNGRPLR-RQINAHRVAP-------------NSPLVVMELMAEGDLVKYLRHLGDTGLGSVEHAQAYLWATQIADGMAYLVAKNYVHRDLAARNCFVNARLIVKIGDFGLCRNVYGQYYYHKKTCGRLPIRWMAPESLRKARFTSQSDVWSYGVVLWEVATMACLPYRGMSHEQVICYTLGGNTLITNTVPTNCPGLLLALMARCWAYDPAKRPTFLRICALLCPRFGDAQFRSSSFY 1488          

Query:  219 EKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSI--VRQHGAPIKLINMRNF-CLEFCPNNC---PRGENLQKY----------CWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECM---NLSSQSSTDYRRED--------------HYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGS-SLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQL--------NITILEGS-VSFNLNRKLCPEKILSFLNSN----VQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVK-----CH----SKVPDISLQNSALTALFMLK----ETTKNVSQYELFNSCSEQNWR-TVEGYIGKPVV--IDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECD-CDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIP----KSNWKPVDSGH-FEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKA-------------------LSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSS-VKIFWSEPKSPNGFILNYFIRYRKYPY----------------------------------------EAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISS--DSIFTEY--RNYXXXXXXXXXXXXXXXXXXXXYYC--KKKYLERTRWVSSNPDYWIIYEI-DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKE-------RQIDDIAAAQFG------SFKATISQH--FDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLS-TGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKL-ELYADMNFRNNSYY 4364
            E +C S+DIR+        NCTV+EGDL I+ V L ++ S P ++EITGSL+IY V G  +L    P L +IRGQ L   YA+V+K T L    L +LRL+  G VR++ NP LC+V+T+NW ++   R        +NM    C + CP  C   P      KY          CW  + CQ+VCS+ C +++  C ++D  RCCHPECLGGCYG G  MCVSC +VL    C+ +C +   +Y NRRC++  +C+    ++ QS + +   +              +YA+ +  CV+ C  G  ++ +TG+CE C     +K C    IH++ D    +GC+S + +Y+SI +  S   ++ L +AF+ L +IE+SLRIV+S++ITSL+FL ++  I           +    N++I  EV +NENL  ++        +         + +   S V F  N +LCP  +    ++     +     LS+ ++ +I V+NG++ +C      +++ +++ SS  ++      H    S  P + L    +T   + +    E+  N+  +++  S   + ++ +   Y        +  L  A  Y+   E     + N L  S+ ++ TT   NPS P     ++     +RLTW  P  PNG ++ Y+IW R L     +F   D C  K+        QS++ + + +  + N      C +C   C               + FL +  T   +  +++P     S W   D      +  V  N  +   E+V       IST    S    T + +               +L  +     E+ ACQ +Q  +S  + A                   L++   S     L CS +  +      K++ D I  ++I+ + +  + V+IFW EP  PN  +L Y IRYR   Y                                         A+  WL T C++   WL       +N ++ +N+     G   LR L  G Y FQI+ F++A  G W+  + F I +  D+    +  R   I+     +  L     L    C  +K+YL  T W S NP Y  IY++ D WEIDR ++D+L W +PLG GSFG VY+GV++ LTTPA   Y    D   + VAVKT+N  +T+ +  +FI EAC+MKQF SYHLV L G+V++   ++     +   F+                  + RI +L  F   +S  +           D    +  G        +  I+ H      PLV+MELM  GDL  YLR  G+ G G V   Q++LWA QIADGM YL+   +VHRDLAARNC++++ LI+KIGDFG+ R+VY   YY K+  GRLP+RWMAPESL    F+  SD+WSYGV+LWE+ T+A LPYRGMSH  VI Y   G +L++ T   N   LLL +M  CW Y+P  RP+FF I   L   + D  FR++S+Y
Sbjct:   39 EVICGSLDIRRPDIFKESINCTVVEGDLIISFVRLPTDASLPYVREITGSLLIYDVHGLDSLAKLLPRLVLIRGQNLIDRYAMVLKSTGLKDAALPSLRLIHRGAVRLEENPDLCHVHTVNWMTLSGYRADAEHTLNVNMNGASCADRCPAQCLSAPITTGPAKYQQRTLYTNAPCWSSSICQSVCSDHCIEHDLACQIHDTERCCHPECLGGCYGNGPHMCVSCSHVLYGDSCISECPEGMLRYLNRRCVTLEQCLWSIPMAVQSDSTFIMSNSTRPAEYNGVPDWHNYAVFNQCCVENCPIGYIRHNVTGQCEPCDERSHRKSCPEFFIHTLKDLVALQGCWSAKAVYMSISDADSDQTAEALARAFATLRVIEHSLRIVRSTAITSLNFLGTVERI---------GSSVTEVNRTITLEVSENENLRALWSPNEGFPHVVNNSNYRTGLKVWSTSPVRFTQNSRLCPASVFRLFDTGALVLMPRSRSLSEAEQNLIRVTNGELVYCNLAMFSLELSDLTSSSVRIQWPQVTSHSLDTSGAPIMPLHADIVTLTLLHQCHVLESHPNLEGHDIDESLRCRIFQVSCAKYADAKCYYQLSGLEAATSYSVRIEIRYPLMRNRL-YSERVHFTTATANPSAPRYAWLDSNGDDSLRLTWMNPSQPNGVISHYLIWVRLLSPQKVNFTSHDFCIKKTDWILSGLGQSSSMVGQQSASHTNLSILPTCRQCFSYCR-------------YLDFLSDVPTSEDVPSSDVPWPFSVSRWTMGDKEELLPVYVVNANGELDHSELVNAVGLFVISTNGGASDTEHTQYMR---------------SLRPFGRVVVELSACQ-MQPAKSVSNAACRAPAPWLGLHPGEFLDIELNRTHWSACETQL-CSPRVTVFGRMPSKDDADEIPATSISCQSSTPNFVEIFWCEPDRPNDLVLYYVIRYRPTAYFLTSERTNSGKVESATTNQVSGSRCNTAIKLEELPDLSTTSAQTAWL-TKCISVGHWL----AFRQNGTHQSNV-----GGTFLRGLPSGSYLFQIQAFSLAGVGPWSPMHIFTIDAYLDTSLDGWSARQILIVALNCSLAALLLTVGLTAIGCHLRKRYLRSTAWTSINPGYIDIYDVTDAWEIDRANIDLLSWKHPLGHGSFGTVYRGVVRCLTTPASTLY---PDSTNVSVAVKTINNTTTLFDHHDFIAEACHMKQFHSYHLVCLLGLVTRTGKNERLPDQHCDSFRGL----------------IRRIRLLTQFGRTSSSNQPFCHPDTTVCTDSQGQSSLGEDSNGRPMRRQITAHRVAPNSPLVVMELMTEGDLVKYLRHLGDTGLGSVEPAQAYLWATQIADGMAYLAAKNYVHRDLAARNCLVDARLIVKIGDFGLCRNVYGQYYYHKKTCGRLPIRWMAPESLQKARFTSQSDVWSYGVVLWEVATMACLPYRGMSHDQVICYTLGGNTLITNTVPTNCPGLLLALMARCWAYDPAKRPTFFRICALLCPRFGDAQFRSSSFY 1504          

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE-----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNF-CLEFCPN------NCPR---GENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCY-GEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRRED----HYAIEDDACVKQCSPGKQQ-NKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHS-KVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGK-PVVIDNLLPAKRYAFYAEAIRSRVENWLE------ISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVR-----VDEVVTNF---PSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWL--NGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTR---WVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            ++C S DIR   +++ LL NCTVIEG L I ++  T        +FP L  +T  L+++ V G ++L   FPNLT+IRG  L +NYA+V+ E   L  +GL +L  +  G VR++ NP LCY++T++W+ I+        + N  +  C + CP        CP+     +  + CW    CQ +C  SC   ++ C  +  N+CCH +CLGGC        CV+C+N L  G CV++C   FY +K  RC+  + C  L ++     + +      Y I   AC+ +C  G    N  +  C  C   C K   G   + S+       GC  +    +    GG++++  L     +L  I   L + +S ++ SL FLR LR+I+G      N            F   DN+NL +++D     ++ N+TI +G + F+ N KLC  +I         T TK   +   I   +NGD A C+ + L    +        +K      PD       L  + + K+   KNV++++  ++C   +W         R  +G   + P  +  +L  K +  YA  +++++    E       S++IY+ T    PS P++  + + SSS+I L W PP  PNG +T Y+++ +  +    + +  D C    K   R  +Q ++   +  N  +  G+    +C  +C K +  +  + ++T      EY  K+F  +N +           H E+ ++  ++  R      ++  ++F   PS   +T S PS E      K    V A E+    +NL H+T Y  EI AC    N  +  ++               CS  + +SA T P+++ D+I    I   V   SV I W EPK+PNG I+ Y + Y++     EL      CV+R  ++  NG                       LR + PG Y  +I+  ++A  G+WT+  HF +    +        +I  V+ I +L  + +      KKK  E      + S NP+Y     +YE D WE+ R  + +L     LG+GSFGMVY+G+ K++             E Q  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   25 EICSSKDIRNNVTNLRLLENCTVIEGHLKILLMFTTKPEDFRGLTFPKLTVVTDYLLLFRVYGMESLSSLFPNLTVIRGNNLFFNYALVLFEMLQLKELGLHSLMNITRGAVRVEKNPDLCYLSTLDWSKILDSVEDNYIVANKNDGECGDVCPGMAKGKTTCPQTTINGHFSERCWTQKHCQRMCPSSC--KHRACTKD--NQCCHDQCLGGCMEPSSPRKCVACRNFLHQGECVERCPAGFYTFKGWRCVDFAFCQALHNRCKQGKQGKGGECYEYVIHQGACIPECPSGYTTINSTSLNCTPCAGLCPKVCMGLKTVDSVTAAQGLRGCTVLNGSLVINIRGGNNIAAELEANLGQLEEITGYLTVRRSYALVSLSFLRKLRLIRGEVQEVGNYS----------FYALDNQNLRQLWD----WSKHNLTIQQGRMFFHHNSKLCMAEIRKMEEV---TGTKNRHVKNDIATKTNGDQASCESQVLKFTTIRTLSDKIIIKWEPFWPPDF---RDLLGFMVLYKDAPYKNVTEFDGQDACGSNSWVIADVDPPQRATDGKEQQEPGYL--ILALKPWTQYAIMVKTQLSASDEHQVHGAKSEIIYVRTNATKPSVPLDPISSSNSSSQIILKWKPPNDPNGNITHYLVFCQQ-QPEASELYKFDYCQKGMKLPSRAPTQVDSGEEQKWNQTEEHGQ--GGRCC-ACPKTEKQLKKEAEET------EY-RKTF--ENYL-----------HNEVFRIRPSRQRRSLVGVANQTHSDFLTTPSIPPNTSSTPSPEEEAEANKITQLVYAKESTV-ISNLRHFTSYQIEIHAC----NHPTDPAR---------------CSMAAYVSARTMPEDHADDIM-GPITFEVAEYSVHIRWIEPKAPNGMIILYEVNYKRLGDTEELHH----CVSRKSYITENGCK---------------------LRVVHPGNYTVRIRATSLAGNGSWTEPTHFYVQDLRVDPSNMLKIVIAPVICIFLLLLMGLAGFIVFKKKQTEGPTGRLYTSPNPEYLSPDEVYEPDEWEVPRDKISLLR---ELGQGSFGMVYEGIAKDIVK----------GEPQTHVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLG 1068          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  YLR    E E         L      A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+  SD WS+GV+LWEI TLA  PY+G+S+  V+++V  GG L      N +  L  +M+ CW YNP  RP+F +II+ L+     +F+  S++
Sbjct: 1077 LVVMELMTHGDLKSYLRCLRPESENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGYLDRPD--NCADRLHNLMQMCWHYNPKMRPTFQEIIEMLKEELHPSFQEMSFF 1281          

Query:  225 VCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE-----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNF-CLEFCPN------NCPR---GENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCY-GEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRRED----HYAIEDDACVKQCSPGKQQ-NKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHS-KVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGK-PVVIDNLLPAKRYAFYAEAIRSRVENWLE------ISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVR-----VDEVVTNF---PSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWL--NGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +C S DIR   +++ LL NCTVIEG L I ++  T        +FP L  +T  L+++ V G ++L   FPNLT+IRG  L +NYA+V+ E   L  +GL +L  +  G VR++ NP LCY++T++W+ I+        + N  +  C + CP        CP+     +  + CW    CQ +C  SC   ++ C  +  N+CCH +CLGGC        CV+C+N L  G CV++C   FY +K  RC+  + C  L ++     + +      Y I   AC+ +C  G    N  +  C  C   C K   G   + S+       GC  +    +    GG++++  L     +L  I   L + +S ++ SL FLR LR+I+G      N            F   DN+NL +++D     ++ N+TI +G + F+ N KLC  +I         T TK   +   I   +NGD A C+ + L    +        +K      PD       L  + + K+   KNV++++  ++C   +W         R  +G   + P  +  +L  K +  YA  +++++    E       S++IY+ T    PS P++  + + SSS+I L W PP  PNG +T Y+++ +  +    + +  D C    K   R  +Q ++   +  N  +  G+    +C  +C K +  +  + ++T      EY  K+F  +N +           H E+ ++  ++  R      ++  ++F   PS   +T S PS E      K    V A E+    +NL H+T Y  EI AC    N  +  ++               CS  + +SA T P+++ D+I    I   V   SV I W EPK+PNG I+ Y + Y++   + EL      CV+R  ++  NG                       LR + PG Y  +I+  ++A  G+WT+  HF +    I  + +     G +                          + S NP+Y     +YE D WE+ R  + +L     LG+GSFGMVY+G+ K++             E Q  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:    6 ICSSKDIRNNVTNLRLLENCTVIEGHLKILLMFTTKPEDFRGLTFPKLTVVTDYLLLFRVYGMESLSSLFPNLTVIRGNNLFFNYALVLFEMLQLKELGLHSLMNITRGAVRVEKNPDLCYLSTLDWSKILDSVEDNYIVANKNDGECGDVCPGMAKGKTTCPQTTINGHFSERCWTQKHCQRMCPSSC--KHRACTKD--NQCCHDQCLGGCMEPSSPRKCVACRNFLHQGECVERCPAGFYTFKGWRCVDFAFCQALHNRCKQGKQGKGGECYEYVIHQGACIPECPSGYTTINSTSLNCTPCAGLCPKVCMGLKTVDSVTAAQGLRGCTVLNGSLVINIRGGNNIAAELEANLGQLEEITGYLTVRRSYALVSLSFLRKLRLIRGEVQEVGNYS----------FYALDNQNLRQLWD----WSKHNLTIQQGRMFFHHNSKLCMAEIRKMEEV---TGTKNRHVKNDIATKTNGDQASCESQVLKFTTIRTLSDKIIIKWEPFWPPDF---RDLLGFMVLYKDAPYKNVTEFDGQDACGSNSWVIADVDPPQRATDGKEQQEPGYL--ILALKPWTQYAIMVKTQLSASDEHQVHGAKSEIIYVRTNATKPSVPLDPISSSNSSSQIILKWKPPNDPNGNITHYLVFCQQ-QPEASELYKFDYCQKGMKLPSRAPTQVDSGEEQKWNQTEEHGQ--GGRCC-ACPKTEKQLKKEAEET------EY-RKTF--ENYL-----------HNEVFRIRPSRQRRSLVGVANQTHSDFLTTPSIPPNTSSTPSPEEEAEANKITQLVYAKESTV-ISNLRHFTSYQIEIHAC----NHPTDPAR---------------CSMAAYVSARTMPEDHADDIM-GPITFEVAEYSVHIRWIEPKAPNGMIILYEVNYKRL-GDTELHH----CVSRKSYITENGCK---------------------LRVVHPGNYTVRIRATSLAGNGSWTEPTHFYVQDLQIILKVQTEGPTGRL--------------------------YTSPNPEYLSPDEVYEPDEWEVPRDKISLLR---ELGQGSFGMVYEGIAKDIVK----------GEPQTHVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLG 1018          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  YLR    E E         L      A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+  SD WS+GV+LWEI TLA  PY+G+S+  V+++V  GG L      N +  L  +M+ CW YNP  RP+F +II+ L+     +F+  S++
Sbjct: 1027 LVVMELMTHGDLKSYLRCLRPESENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGYLDRPD--NCADRLHNLMQMCWHYNPKMRPTFQEIIEMLKEELHPSFQEMSFF 1231          

Query:  270 LTNCTVIEGDLYIAMVTLTSE-----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVR--QHGAPIKLINMRNFCLEFCPNN------CPR---GENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGD-EMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDH-YAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHS-KVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEG-YIGKPVVIDNLLPAKRYAFYAEAIRSR--VENWLEI----SDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDT-IMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSS--VKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWI--IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            L NCTVIEG L I ++  T        SFP L  IT  L+++ V G ++L   FPNLT+IRG  L +NYA+V+ E   L  +GL +L  +  G VR++ NP LCY++T++W+ I+   +    +   N R  C + CP        C +     +  + CW+ + CQ +C  +C   ++ C ++D  RCCH +CLGGC   G+   CV+C+N+L    CV +C    Y +K  RC+S + C +L ++       + H Y I + AC+ +C  G      T  C+ C   C K   G   I S+       GC  +    +    GG++++  L     +L  I   L I ++ ++ SL FLR LR+I+G +    N            F   DN+NL +++D     ++ N+TIL+G + F+ N KLC  +I   +     TK + +K D  I   +NGD A C++ +L    + +S  +  ++      PD       L  + + KE   KNV++++  ++C   +W         R  +G   G P  +  L+P K +  YA  ++++  V +  ++    S++IY+ T +  PS P++  + + SSS+I L W PP  PNG +T Y + Y+  E    + +  D C    K   R  +       +  N  + QGE     C  +C K +  +  + ++T   +  + YI       NE+            FE K     +++     + N   + I  I+ P+  N++        + +++     ++LHH+T Y  EIQAC  L ++                     CS  + +SA T P+   D+I  +  +  +      V I W EPK+PNG I+ Y I YR+     EL      CV+R                   I+ +K+    LR   PG Y  +I+  ++A  G+WT+  +F +                                                 PD +I  +Y  D WE+ R+ + +L     LG+GSFGMVY+G+ K++             E +  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:    1 LENCTVIEGHLKILLMFKTRAEDFRGLSFPKLVMITDYLLLFRVYGLESLSDLFPNLTVIRGNNLFFNYALVMFEMLQLKEVGLHSLMNITRGAVRMEKNPDLCYLSTLDWSKILDSVEDNYIVANKNERE-CGDICPGTIVGKITCVQTTINGHFGERCWNQDNCQRICPAAC--KHRACTLDD--RCCHDKCLGGCSEPGNASACVACRNLLYGNMCVDRCPPDHYIFKGWRCVSFAFCQDLHNRCKQKKASDCHQYVIHNGACIPECPSGFTIVDATLNCKPCAGLCPKLCTGLQTIDSVTAAQALRGCTVLNGSLVIKIRGGNNIAAELEANLGQLEEITGYLTIRRAYALVSLSFLRKLRLIRGETQEIGNYS----------FYALDNQNLRQLWD----WSKHNLTILQGRMFFHYNAKLCLSEIRK-MEEVTGTKDRHTKND--IALRTNGDQASCENRQLNFTQIRVSSKNIMIRWEPFWPPDF---RDLLGFMVLYKEAPYKNVTEFDGQDACGSNSWVITDVEPPPRATDGNKPGDPGCV--LMPLKPWTQYAIMVKTQLSVSDEHQVHGAKSEIIYVLTNQTRPSVPLDPISSSNSSSQIILKWKPPADPNGNITHYRVAYQKQE-EDSELYKFDYCQKGMKLPSRAPTHYTTEEEQKWNQTEEQGE--TSSCC-ACPKTETELKKEAEETEFRKTFENYI------HNEV------------FEPKPSRRRRSLG----IANSTHSTI-LITPPTFPNVS-----APTIVSSKESIVISHLHHFTSYQIEIQACNHLTDIAF-------------------CSMATYVSARTMPEVKADDIFGAVTHEILPEEPEFVYIHWQEPKAPNGMIVLYEINYRRVSDTEELHH----CVSR-------------------ISYEKTRGCKLRVGHPGNYSVRIRATSLAGNGSWTEPTYFFM-------------------------------------------------PDIFIYFLYVPDDWEVAREKITVLR---ELGQGSFGMVYEGIAKDIVK----------GEPETRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLG 959          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  YLR    + E         L      A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+  SD WS+GV+LWEI TLA  PY+G+S+  V+++V  GG L    S   ++ +  +M+ CW YNP  RP+F +II+ L+     +F+  S++
Sbjct:  968 LVVMELMTHGDLKSYLRSLRPDAENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDGWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGYLDRPES--CAERINNLMQMCWQYNPKMRPTFNEIIEMLKDDLHPSFQEVSFF 1172          

Query:  213 SNEKVC-QSIDIRKR-SHVSLLTNCTVIEGDLYIAMV--------TLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLY-IGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCP----NNCP-----RGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGC-YGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCGRVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKC---HSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTV------EGYIGKPVVIDNLLPAKRYAFYAEAIRSRVEN-----WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXK-TNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIK---QNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYC-KKKYLER----TRWVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +N ++C  +IDI    S    L NCTV+EG L I ++         +    SFP L  IT  L+++ V G  +L   FPNLT+I+G+ L YNYA+VI E N L  IGL +LR +  G VRI+ N  LCY+++++W+ I+      I        C + CP    NN P      GEN +  CW  N CQ VC + C +  + C  +  N CCHP+CLG C   + D  C +C++    GRCV  C    YK++  RCI+   C   S     DY   D + I    C+  C PG  +N+     C  C   C K   G+V I S++     +GC  I+ +++I+I+ G +  S+ L      +  +   +RI  S ++ SL FL+SLR I G     +             F   DN++L  ++D     +Q N+TI  G + F  N KLC  +I       ++T  K   ++E   N  NGD A C  E  I++ +N S  S  +       + PD   ++     ++  +   +N+++++  + C   +W TV      E      V +  L P  +YA + +A+   VE+         S+++Y+ T+   P+ P+ ++  +  S+ + + W+PP+ PNG  T Y++ W +  E    + +  + C  + K   R+ +     IS+ T+  N   G  D   C      ++ L  I+ D    +  + ++  S  K    NE  + +   V +  F    +  N ++       NF  ++      P +E          QV   E      NL  +T Y  ++ +C   + VQ                    CS  + + + T P E  D+I    +       SV + W EP  PNG IL Y I++R  P   + +     CV+R  +     +                    L +L PG Y  +++  ++A  G+WT+   F +        Y N+  +  + I  ++  +  L      KK+  +R      + S NP+Y+   E+   D WE+ R+ + M      LG+GSFGMVY+G+ K +            DE +  VA+KT+N ++++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   28 ANGEICGPAIDIGNDISEFKKLENCTVVEGYLQILLIGNKINNNHEVFRTLSFPKLTMITDYLLLFRVNGLDSLSTLFPNLTVIQGRNLFYNYALVIFEMNSLKDIGLYSLRNITRGAVRIEKNTELCYLDSVDWSLIMNADFNVIDGNKNPKECGDVCPGIVENNTPCIKTKIGENTRDRCWTSNHCQQVCPKECGQ--RACTAS--NECCHPQCLGSCTVPDSDRACAACQHYYHEGRCVPDCPPGTYKFEGWRCITMDLC---SRVHLPDY---DRFVIHGGECMADCPPGFTRNESQSMFCSACDGLCDKICDGKV-IDSVDSAQSLKGCTVIKGNLHINIRRGNNIASE-LENFLGLIKTVSGYVRIRHSHTLGSLSFLKSLRFIYGEDLYDDMY----------AFSAVDNQHLQFLWD----WSQHNLTIGTGKLFFRFNHKLCMSEIRKMW---MKTGIKEKFVEEDFRN--NGDRASC--ESKILKFINNSTGSNIITLTWERYRPPD--YRDLVSFVVYYKEAPFQNITEFDGQDGCGSNSWMTVDVDLPPEKNKNPGVYLSGLKPWTQYAVFVKAVTLVVEDKDRHILGAKSELVYIRTKPSAPTMPVEVRVYSNWSTSLVVRWSPPVSPNGNHTYYLLRWQQQGE--DRELYQHNYCSKELKLPIRMSATGVTDISEDTDPTNPESGGRDITPCCPCPKSDKELKRIEDDTYYRKAFENFLHNSIFKPRPSNERRRRDLFGVANSTFIHALLGMNGSL----AEGNFSHSEHPRREYPFLER---------QV--KERSADIHNLRPFTVYRIDLHSCN--EEVQQ-------------------CSPAAFVFSRTKPAEKADDI-PGPVTWEGLEDSVILKWPEPVRPNGLILLYEIQFRLGPEMEKHE-----CVSRQHYKEHRGV-------------------RLTNLGPGNYSARVRATSLAGNGSWTEPIAFYVPQ---LDRYENFLYLIIIPIAAMILIIVGLALVMVNKKRKNDRLGNGVLYASVNPEYFSAAEMYVPDEWEVAREKITMCR---ELGQGSFGMVYEGIAKGVVK----------DEPETRVAIKTVNESASMHERIEFLNEASVMKEFNCHHVVRLLG 1062          

Query: 3759 LVIMELMEFGDLAGYLR----KQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    K+           +    A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI TLA  PY+GMS+  V+++V +GG L      N   +L  +M  CW YNP  RPSF +II  ++   +  FR  S++
Sbjct: 1071 LVIMELMTRGDLKSYLRTLRSKESTSSLPLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTMSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEDLEPPFREVSFF 1274          

Query:  213 SNEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE--------YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNF-CLEFCPN------NCPR---GENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCGRVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKC---HSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTV------EGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEI---SDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLE 2069
            S E     IDIR   S    L NCTV+EG L I ++   +          SFP L+ +T  L+++ V G  +L + FPNLT+IRG+ L YNYA+VI E T+L  IGL NL+ +  G +RI+ NP LCY+++++W+ I+          N ++  C + CP        CPR    +N    CW  N CQ  C+  C  + + C   D   CCHP+CLG C    ++M C +C++    GRCV  C    Y+++  RCI+   C  +   S  D      + I +  C+ +C PG  +N      C  C   C  K C    I S++     +GC  I+ +++I+I+ G +  S+ L      +  +   +RI  S ++ SL FL+SLR I G     N             F   DN++L  ++D     +Q N+TI  G + F  N KLC  +I        +  + + +++E  I  +NG+ A C  E  I++  N    S  +K      + PD       ++ +   KE   +N+++++  + C   +W  V      +      V++  L P  +YA + +AI   VE+   +   S+V+Y+ T+   PS P +++    SSS + + W PP+ PNG  T Y++ W +  E
Sbjct:   24 SGEICGPHIDIRNDISEFKKLENCTVVEGYLQILLIGDKNHNPYQEFRTLSFPKLRMVTDYLLLFRVAGLDSLSMLFPNLTVIRGRNLFYNYALVIFEMTSLKDIGLYNLKNITRGAIRIEKNPELCYLDSVDWSLIMDAEFNNYVAGNKQSKECGDVCPGIMEDRPECPRTSFNDNYSYRCWTSNHCQKECAPKC--DRRVC--TDNKECCHPQCLGSCTEPDNDMACAACQHYYHEGRCVPDCPPGTYRFEGWRCITMETCARVHLPSEVD------FVIHNGECMPECPPGFTRNDSQSMFCSACDGLCD-KVCEIKTIDSVDAAQSLQGCTVIKGNLHINIRRGNNIASE-LESFMGLIQTVTGYVRIKHSHTLGSLSFLKSLRYINGEELLDNAY----------AFSALDNQHLQYLWD----WSQHNLTIRAGKLFFRSNPKLCVSEIRKMW----EKTSIIERMEEDDIR-NNGERASC--ESHILKFKNNQTQSNRIKLTWERYRPPDY---RDLISFIVYYKEAPFQNITEFDGQDGCGSSSWTMVDVDLPPDKATDPGVLLYPLKPWTQYAIFVKAITLVVEDKHTLGAKSEVVYIRTKASEPSMPRDVRAYANSSSSLVVKWTPPISPNGNSTFYLVRWQQQSE 643          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSL 4211
            LVIMELM  GDL  YLR    + +G  S+    L      A +I+DGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+ +SD+WS+GV+LWEI TLA  PY+GMS+  V+++V +GG L
Sbjct: 1069 LVIMELMTRGDLKSYLRSLRSKQQGSCSQPLPSLKKMIQMAGEISDGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLL 1224          

Query: 2439 STISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTI---NTRVNGSSVKIFWSEPKSPNGFILNYFIRYR--KYPYEAELDWLSTPCVTRPEW--LNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKK-----YLERTRWVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
             T+++    N T     M      E  + F+    YTE+        ++ N+Q      +  +  +  V    CS+ + + + T P E  D+I  +     + RV   +V + W EP  P+G IL Y I++R    P + E       CV+R ++  L G  +        TN+     GF        G Y  +++  ++A  G+WT+   F +       E   Y  I   +I+++     +    + +KK           + S NP+Y+   E+   D WE+ R+ + +      LG+GSFGMVY+G+ K +            DE +  VA+KT+N ++++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:  740 GTLARGLGRNATGQEGNMTDPELLEPVYPFSEFTVYTEF-------TEIHNLQPFTVYRIDVHACNHEVER--CSAAAFVFSRTKPAEKADDIPGTVTHEKDERVE-DTVVLRWPEPPRPSGLILMYEIKFRLGTEPEKHE-------CVSRQQYRELRGARL--------TNL-----GF--------GNYSVRVRATSLAGNGSWTEPVSFYVPPPHQAYENMLYLAITIPIIVLLALIALISSIIFIRKKRNNDRLGNGVLYASVNPEYFSAAEMYVPDEWEVSREKITLCR---ELGQGSFGMVYEGIAKGVVK----------DEPETKVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLG 1060          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFV--------------SENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    + E F               S  +    A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI T A  PY+G+S+  V+++V  GG L+   +    + L  ++  CW YNP  RP+F +I+  L      +F   S+Y
Sbjct:   90 LVIMELMTRGDLKSYLRSLRPDAEDFTETIVLEKKPTRPPSSLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFVMDGGLLVLPPA--CPERLQELIRKCWQYNPRMRPTFLEILDGLAPDLHPSFHEFSFY 303          

Query: 3228 YEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            Y  D WE++R  V M+     LG+G+FGMVY+G+ + +             E +  VA+KT+N  +T+ ER EF+NEA  MK F  +H+V+L G
Sbjct:    1 YIADEWEVERDKVKMMR---ELGQGTFGMVYEGLARGIVK----------GEDETRVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLG 81          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  YLR    + E   +   S L      A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI T A  PY+G+S+  V+++V  GG L+   +    + L  ++  CW YNP  RP+F +I+  L      +F   S+Y
Sbjct:  138 LVIMELMTRGDLKSYLRSLRPDAEKKPTRPPSSLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFVMDGGLLVLPPA--CPERLQELIRKCWQYNPRMRPTFLEILDGLAPDLHPSFHEFSFY 342          

Query: 3195 WVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            + S NP+Y+    +Y  D WE++R  V M+     LG+G+FGMVY+G+ + +             E +  VA+KT+N  +T+ ER EF+NEA  MK F  +H+V+L G
Sbjct:   35 YASVNPEYFSTADVYIADEWEVERDKVKMMRE---LGQGTFGMVYEGLARGIVK----------GEDETRVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLG 129          

Query:  723 VCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQN--KITGRCEICGSECSK--KYCGRVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW--RTVEGYIG--------KPVVIDNLLPAKRYAFYAEAI-----RSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDC--DKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVP-----ANETYFK-----FTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKI 3062
            VC   C +           +CCH ECLGGC+  G E  C++C++    G CV  C    Y+Y   RC++   C     Q+  DY  ++   +    C+  C  G  +N  + +  C  C   C K  KY G V I+S+    E  GC  ++ ++ I I+ GG++++  L      + ++   ++I +SS++ +L FL++LRII+G+  ++ N            F V DN+NL +++D      + N+T+L G + F  N KLC  +I       V T T   +    +    NGD   C+ + L       S     ++ +   P        L+     KE   KNVS+++  ++C   +W  R +E   G          +++ +L P  +YA +  A         + N    S+V+Y+ T+    S P+++   + SS+++ + W  P +PNG VT YI+ W R  E    +    D C    K  RR  + S+  +     GNQ++ +     +KC  +C K Q  +  + ++   QF+  +  ++F+                H +I         R D    +   TD +T S  S  +L    ++++  P     A E  F       T L H+T Y  +IQAC     +                   + CS+ + +SA T P  + DNI    +   V  + + + W EP  PNG ++ Y ++Y+          +   CV+R  +  G                     + +R L PG Y   I+  +++  G+WT+ +HF+I
Sbjct:    1 VCPPECGRRA----CTKSGQCCHEECLGGCHQAGSEHHCLACRHYWHKGICVLDCPLGTYRYDGWRCVTAEFC-----QAPYDYSTQN--VLHHGDCLPDCPSGYIRNVTRNSMTCTKCDGPCPKVCKY-GNVNINSLTAAQELYGCTELDGNLTIDIR-GGNNIAAELETNLGLIEMVTGYVKIKRSSALVTLAFLKNLRIIRGDMLDEGNYS----------FYVLDNQNLQQLWD----WTKHNLTVLRGKLYFAFNHKLCMSEIYRM---EVVTGTYGRQSRTDLNPKENGDRTSCESKFLRFTGNETSSDKIKLEWYHTWP--KYDRDLLSYTVYYKEAPFKNVSEFDQQDACGSNSWTARDLEFRAGLNPQEMSNPSIILLSLKPWTQYAIFVRAFTLTTTSGDINNQGAKSEVVYIRTKANASSIPLDVIAGSNSSTQLVVKWRAPAYPNGNVTHYIVRWQRQHE--DPELRKHDYCNKVLKVPRREPATSSIDMEPGARGNQSELDTSLAPEKCC-ACPKTQAQLRQEAEEA--QFMKTF--ENFL----------------HNQIFATRLRNMHRPDRKRRDMFGTDNTTDSGNSTSSLIGS-EEVIPTPVVYTFAEEMVFGKERITITGLRHFTAYRIQIQACNHASEL-------------------VGCSAPAYVSARTQPHFDADNIT-GHVKCEVVKNIIYLQWKEPSDPNGLVVLYEVKYQLGGSRFNFSQIQQHCVSRSSYREGKG-------------------FQVRHLLPGDYTAHIRAISLSGNGSWTEPFHFRI 720          

Query: 3762 VIMELMEFGDLAGYLRKQGEEGEGFVSENQSH------------------LWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKL-LLGIMENCWLYNPDDRPSFFDIIQKL 4322
            ++ E M  GDL  YLR+   E     S   +                     A Q+A GM YL+E KFVHRDLA RNC++ + L++KI DFG+++ +Y   YY+      +P+RWM PES+    ++  SD+W++GV+LWEI +    PY GMSH +VI +V  G  L      +   L L  +M  CW + P DRPSF  +   L
Sbjct:   38 LLFEFMPHGDLNEYLRRCSSEAGLAASSPPARAPTSSGSEPVSLCCADKLFVATQVAAGMAYLAERKFVHRDLATRNCLVGNRLVVKISDFGLSQSIYAADYYKANENDAIPIRWMPPESIFYNRYTSESDVWAFGVVLWEIFSHGLQPYFGMSHEEVIYFVRDGNVLACP---DGCPLDLYNLMRLCWAHAPADRPSFASVQHVL 240          

Query:  723 VCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVL----SNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPG-----KQQNKITGRCEICGSECSKK-YCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHS-KVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKP-----------------VVIDNLLPAKRYAFYAEAI------RSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYR----SLEIFGDDFFMEDVC 2105
            VC   C +       +    CCH ECLGGC    D + CV+C++ +    +  RCV  C    Y++K  RC++ + C  L        R   ++ + D  C  +C  G     + ++  +  C+ C   C K  Y G  +I S+    E  GC  IE   +    GG++++  L      +  +  S++I +S ++ SL F R+L  I G+S +  N+           F V DN+NL +++D     ++ N+TI +G + F+ N KLC  +I +      +T TK  + D  I   +NGD A C+   L    + ++     ++  S ++PD   ++     +F  +   +NV++++  ++C   +W +V+  +  P                 +++  L P  +YA + +A         R  N  + S +IYL T    PS P ++ + + SSS++ + W PP FPNG VT Y++ ++    + E++  D+ +   C
Sbjct:    1 VCDTKCGRRA----CSSAGDCCHDECLGGCSAPDDPLACVACRHYVHVDGAAARCVPDCPAGTYRFKGWRCVTAAFCRVLHEAC---VRECINWVLHDGECRPECPSGYTMENETRSDGSMSCKKCDGLCPKVCYVGTKVIDSVTAAQELHGCTIIEGNLVINIRGGNNIATELEANLGLIEEVTGSVKIKRSYALVSLSFFRNLHTIHGDSQDPGNHS----------FYVLDNQNLQQLWD----WDKHNLTIRKGKMFFHFNPKLCLSEIYTM---EEKTHTKGRQEDSDISLKTNGDQASCESTVLTFTQIQMTFDKILLRWQSYRLPD--YRDLLGFVVFYKEAPYQNVTEFDGQDACGSNSWTSVD--VDPPPLKGNGGGNSWGSSSPGILLRGLQPWTQYAIFVKAFVLTSSDEGRGNNGAK-SKIIYLRTNASTPSTPQDVFSVSNSSSQLLVKWRPPAFPNGNVTSYVVRWQQQAENTELYEFDYCLPGTC 471          

Query: 3762 VIMELMEFGDLAGYL----RKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPS 4298
            VIME ME G L   L    R    E    ++ENQ      +   G+ +L   K +HRD+ + N ++NS  ++KI DFG   ++      R    G     WMAPE +    + +  D+WS G++L E++     PY        +  ++  GS       + SK     ++ C   N + R S
Sbjct:  450 VIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGT--PYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIE-GEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRAS 629          

Query: 3798 GYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPS 4298
            G LR+        +SEN+S  +  Q   G+ YL     +HRD+ A N ++++   +K+ DFG++  V           G L   WMAPE L +   S  SD+WS G  + E+LT  + PY  ++  + I Y  +  +     SF  S+ L   +  C++ N   RP+
Sbjct:  105 GSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTL---AGTL--NWMAPEILGNRGASTLSDIWSLGATVVEMLT-KNPPYHNLTDAN-IYYAVENDTYYPPSSF--SEPLKDFLSKCFVKNMYKRPT 262          

Query: 3762 VIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLS--GYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLL------GIMENCWLYNPDDRPSFFDIIQKL--ELYADMNFRN 4352
            + +E +  G +   +R  G   E  +     HL   Q+  G+ YL     +HRD+ A N +++   I KI DFG++R    D Y   +   R  V WMAPE + +  GY +K  D+WS G I+ E+        R  S+ +V+  + K G   S        L L        ++ C+  NP+ RP+  +++     E+    NF++
Sbjct: 1255 LFLEYVAGGSVGSLIRMYGRFDEPLIK----HL-TTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRK-SKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAK-VDIWSLGCIVLEMFAGK----RPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETFNFKS 1450          

Query: 3762 VIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMA--------RDVYYDCYYRKENKGRLPVRWMAPESL---LSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHD---VIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDII 4313
            ++ME    G  +  L++    G   + E +      ++  G+ YL E + +HRD+ A N ++N   ++K+GDFG++        RD +    Y           WMAPE +   + GY  K +D+WS G+  +E+  L  LP   +S +D   V+  + K       G F  S      +  C +  P DRPS ++++
Sbjct:   91 IVMEYCGGGSCSDLLKRSYVNG---LPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKRDTFVGTPY-----------WMAPEVVCCEVDGYNEK-ADIWSLGITTYEL--LKGLP--PLSKYDPMKVMTNLPKRKPPKLQGPF--SDAAKDFVAGCLVKTPADRPSAYNLL 267          

Query: 3765 IMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMAR------------DVYYDCYYRKEN-KGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNS 4358
            ++E    GD  G ++K G      ++E  +  +A QI D +  L  +  +HRD+   N +++  + +K+ DFG A+              Y+D Y + ++  G     +++PE L   Y     D+W++G IL+++L     P++  + +   Q V K     + G     +++  +++   + +P+DR +   I   L  + ++NF + S
Sbjct:  202 LLEYAPHGDFLGLIKKYGS-----LNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGT--AEYVSPELLNDNYTDSRCDIWAFGCILYQMLA-GKPPFKAANEYLTFQKVMKIQYAFTAG---FPQIVKDLVKKLLVRDPNDRLTIKQIKAHL-FFHEVNFEDGS 400          

Query: 3759 LVIMELMEFGDLAGYLRKQG-----EEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM+ GDL  +LR        E  E   +  Q    A +IADGM YL+  KFVHRDLAARNCM+N+ L +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+  SD+WS+GV++WE+ TLAS PY G S+ +V++YV  GG +      +    L  +M  CW ++P  RP+F  II  +E      FR NS+Y
Sbjct:   95 LVVMELMDNGDLKNFLRSHRPEVTMESDEPPPTLQQMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNANLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQPYPGKSNEEVLKYVVDGGVMPKPD--DCPDRLFDLMTLCWQFSPKARPTFLSIISLIEEDLSQEFRENSFY 299          

Query: 3225 IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +Y  D WE+ R+ + ++     LG GSFGMVY+G   ++            ++ +  VAVKT++ N++I +R EF+ EA  MK FQ  H+V+L G
Sbjct:    5 VYIADEWEVPREKIKLIR---ELGNGSFGMVYEGEATDIVP----------NKPKCKVAVKTVSENASIRDRIEFLQEASIMKAFQCNHVVRLLG 86          

Query: 3759 LVIMELMEFGDLAGYLR-----------KQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKL 4322
            +VI+E   +G+L  +LR           K   + E   +   + + + QI+ GM +L+  K VHRDLAARN ++    ++K+ DFG+ARD+Y D  Y K   G LPV+WMAPESL    +++ +D+WS+G++LWEI+TL   PY G+    ++ Y+S+G  +      N    +  IM +CW+  PD RP F  ++++L
Sbjct:  115 MVIIEFAPYGNLLSFLRARREVFEPTWTKTNPDPEAEYTLVDTSMASYQISKGMEFLARKKCVHRDLAARNVLVGPDYVMKVSDFGLARDIYQDDLYVKTTSGLLPVKWMAPESLFDRVYTEKTDVWSFGILLWEIMTLGGTPYPGLPTEQLLDYLSEGQRMAQPQ--NCPLEIYTIMRDCWMQLPDQRPHFGTLVERL 311          

Query: 3747 DKMPLVIMELMEFGDLAGYLRK-QGEEGEGF----------VSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLL-SGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKL 4322
            D  PLVI+E +  GDL GYLRK +GEE + +          +S  Q   +A Q+ADGM YLS  K +HRDLAARN ++    + K+ DFGMA+DV  +  Y +  +GRLPV+W A E+L+  G ++  SD+WS+GV+L+EI T+   PY G++  D+   +  G  +      +++  L  +M +CW   PDDRP+F   +QKL
Sbjct:   87 DGRPLVIIEYVPHGDLLGYLRKSRGEEDDYYSDPEIKPKTSLSSQQLIRFAWQVADGMEYLSSQKIIHRDLAARNILVGEGEVCKVADFGMAKDVSNEDIYIRTTEGRLPVKWTAVEALIGGGEYTTLSDVWSFGVVLYEICTIGGEPYPGIAGKDIPDCLETGYRMPCPTHVDAT--LYQVMASCWATCPDDRPTFAS-LQKL 287          

Query: 3747 DKMPLVIMELMEFGDLAGYLRK-QGEEGEGF----------VSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLL-SGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDI 4310
            D  PLVI+E +  GDL GYLRK +GEE   +          +S  Q   +A Q+ADGM YLS  K +HRDLAARN ++    + K+ DFGMA+DV  +  Y +  +GRLPV+W A E+L+  G ++  SD+WS+GV+L+EI T+   PY G++  D+ +Y+  G  +      +++  L  IM +CW   PD RP+F  +
Sbjct:   87 DGRPLVIIEYVPHGDLLGYLRKSRGEEDSYYPDPEIKPKTSLSSQQLVRFAWQVADGMQYLSSQKIIHRDLAARNILVGEGEVCKVTDFGMAKDVQNEDIYIRTTEGRLPVKWTAIEALIGGGEYTTQSDVWSFGVVLYEICTIGGEPYPGIAGKDIPEYLEAGYRMSCPTHLDAT--LYEIMASCWATCPDMRPTFTSL 284          

Query: 3762 VIMELMEFGDLAGYLR--KQGEEGEGFVSENQSHLWAI--QIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQK 4319
            +I E M  GDL  YLR  K  E       ++   L  I  Q+A GM Y++ ++FVHRDLA RNC++ + +++KI DFGM+RDVY   YY+   +  LP+RW+APE+ L G F+  SD++SYGV+LWEI T    PY G ++ +V +++ KG  L      +  + +  IM++CW   P++R   F +IQK
Sbjct:   38 MIFEFMGEGDLNHYLRSAKPAESSAYKGPDDAKDLVGIAEQVAAGMEYVASLRFVHRDLATRNCLVGTDMVVKIADFGMSRDVYGSDYYKMSRETMLPIRWLAPEAFLYGKFTVKSDVYSYGVLLWEIFTFGLQPYYGYTNKEVTEFIKKGIHLGRPD--DCPQFVYLIMKDCWSREPEERVD-FGLIQK 224          

Query:  225 VCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE-----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNF-CLEFCPNNCPRGENL----------QKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRRED-----HYAIEDDACVKQCSPG-KQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLE------ISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGE----CDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQT-VRVDEVVTNFPSTDISTISKPSIENLT-NHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +C S DIR   +++  L NCTVIEG L I ++  T        SFP L+ +T  L+++ V G ++L   FPNLT+IRG  L +NYA+V+ E   L  +GL +L  +  G VRI+ NP LCY++T++W+ I+        + N  +  C + CP   PRGE L           + CW    CQ +C   C    ++    D  +CCH +CLGGC        CV+C+ +   GRCV++C K F  YK  RC+S   C  L  +   +  R        Y I + AC+ +C  G    N     C  C   C K   G   + S+       GC  +    +    GG++++  L  +  +L  I   L + +S ++ SL F R LR+I+G      N            F   DN+NL +++D     ++  + IL+G + F+ N KLC  +I         T  K  ++   I   +NGD A C++  L    +        +K     P  S     L  + + KE   +NV++++  ++C   +W         R  EG   +      ++P K +  YA  +++++    E       S++IY+ T    PS P++  + + SSS+I L W PP  PNG +T Y+++Y+  +    + +  D C    K   R+ +Q ++   K  N  + +G+    C C K  +   K +      +D    +  + Y+       NE+            FEIK+    ++ + V      F +T  S    P  +  T    K +V V A E+    +NL H+T Y  EI AC          +KA+             CS  + +SA T P+E  D+I    I + V  ++V I W EP +PNG I+ Y + Y++     +L +    CV+R  +                   +K     L+ + PG Y  +I+  ++A  G+WT+   F +      +E+ +                       C+ +      + SSNP+Y     +YE D WE+ R  + +L     LG+GSFGMVY+G+ K++             E +  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:    8 LCPSKDIRNNVTNLQTLENCTVIEGHLKILLMFKTKPENFRGISFPKLRVVTDYLLLFRVYGLESLSDLFPNLTVIRGNNLFFNYALVVFEMLQLRELGLHSLMNITRGAVRIEKNPDLCYLSTLDWSKILDTVEDNYIVANKNDRECGDVCPG-VPRGETLCPTTTLNGHFSERCWTQKFCQKMCPVQC----KHGACTDGGQCCHDQCLGGCLKPNSTSDCVACRGLQHEGRCVEQCPKKFVVYKGWRCVSSDFCQELHHRCRREKERSKSAECHEYVIHNGACIPECPSGYTTVNSSALNCSPCAGLCPKVCIGLKTVDSVTAAQALRGCTILNGSLVINLRGGNNIAAELEASLGQLEEITGYLTVRRSYALVSLSFFRKLRVIRGEEQEVGNYS----------FYALDNQNLRQLWD----WSKHKLAILQGRMFFHYNSKLCMSEIRRMEEV---TGLKDRRVKNEIALKTNGDRASCENHVLTFTQIRTMSDKIMIKWKPFWP--SDFRDLLGFMVLYKEAPFQNVTEFDGQDACGSNSWVIADVDPPRRASEGEKDQTEPGHLIMPLKPWTQYAIMVKTQLSASDEHQVNGAKSEIIYVRTNATRPSVPLDPISSSNSSSQIILKWKPPNDPNGNITHYLVFYQR-QPEASELYKFDYCQKGMKLPSRVPTQVDSGEEKKWNQTEEEGQGKQCCTCPKTDKELKKEK------EDSEYRKTFENYL------HNEV------------FEIKRPRQRRSAMGVANQTLPFLTTAPSPTGIPDEDEKTFESTKTVVTVHAKESTV-ISNLRHFTSYQIEIHAC----------NKAIPT-----------CSMAAFVSARTMPEEKADDI-LGPIRSEVTENTVHIEWQEPATPNGIIILYEVIYKRLVDSEDLHY----CVSRKMY-------------------KKMHGCKLKVMHPGNYSVKIRATSLAGNGSWTQPSFFYVQD---LSEWES----------------------GCQTQGPSGPIYASSNPEYLSANDVYEEDEWEVPRDKIHILR---ELGQGSFGMVYEGLAKDIVK----------GEGETHVAVKTVNESASLRERIEFLNEASVMKAFTCHHVVRLLG 1019          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  YLR    + E         L      A +IADGM YL+  KFVHRDLAARNCM+   L +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+  SD WS+GV+LWEI TLA  PY+G+S+  V+++V +GG L      N    L  +M+ CW YNP  RP+F +II+ L      +F+  S++
Sbjct: 1028 LVVMELMTHGDLKSYLRSLRPDAENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMEGGFL--DRPENCPDRLHNLMQMCWQYNPKMRPAFQEIIEMLRDDLHPSFQEVSFF 1232          

Query:  213 SNEKVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTSE-----YSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKET-NLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNF-CLEFCPNNCPRGENL----------QKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEM-CVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRRED-----HYAIEDDACVKQCSPG-KQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNW---------RTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLE------ISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGE----CDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQT-VRVDEVVTNFPSTDISTISKPSIENLT-NHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKIS--SDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            ++  +C S DIR   +++  L NCTVIEG L I ++  T        SFP L+ +T  L+++ V G ++L   FPNLT+IRG  L +NYA+V+ E   L  +GL +L  +  G VRI+ NP LCY++T++W+ I+        + N  +  C + CP   PRGE L           + CW    CQ +C   C    ++    D  +CCH +CLGGC        CV+C+ +   GRCV++C K F  YK  RC+S   C  L  +   +  R        Y I + AC+ +C  G    N     C  C   C K   G   + S+       GC  +    +    GG++++  L  +  +L  I   L + +S ++ SL F R LR+I+G      N            F   DN+NL +++D     ++  + IL+G + F+ N KLC  +I         T  K  ++   I   +NGD A C++  L    +        +K     P  S     L  + + KE   +NV++++  ++C   +W         R  EG   +      ++P K +  YA  +++++    E       S++IY+ T    PS P++  + + SSS+I L W PP  PNG +T Y+++Y+  +    + +  D C    K   R+ +Q ++   K  N  + +G+    C C K  +   K +      +D    +  + Y+       NE+            FEIK+    ++ + V      F +T  S    P  +  T    K +V V A E+    +NL H+T Y  EI AC          +KA+             CS  + +SA T P+E  D+I    I + V  ++V I W EP +PNG I+ Y + Y++     +L +    CV+R  +                   +K     L+ + PG Y  +I+  ++A  G+WT+   F +   SD ++        I   V+++++     +V    + +      + SSNP+Y     +YE D WE+ R  + +L     LG+GSFGMVY+G+ K++             E +  VAVKT+N ++++ ER EF+NEA  MK F  +H+V+L G
Sbjct:   53 AHADICPSKDIRNNVTNLQTLENCTVIEGHLKILLMFKTKPENFRGISFPKLRVVTDYLLLFRVYGLESLSDLFPNLTVIRGNNLFFNYALVVFEMLQLRELGLHSLMNITRGAVRIEKNPDLCYLSTLDWSKILDTVEDNYIVANKNDRECGDVCPG-VPRGETLCPTTTLNGHFSERCWTQKFCQKMCPVQC----KHGACTDGGQCCHDQCLGGCLKPNSTSDCVACRGLQHEGRCVEQCPKKFVVYKGWRCVSSDFCQELHHRCRREKERSKSAECHEYVIHNGACIPECPSGYTTVNSSALNCSPCAGLCPKVCIGLKTVDSVTAAQALRGCTILNGSLVINLRGGNNIAAELEASLGQLEEITGYLTVRRSYALVSLSFFRKLRVIRGEEQEVGNYS----------FYALDNQNLRQLWD----WSKHKLAILQGRMFFHYNSKLCMSEIRRMEEV---TGLKDRRVKNEIALKTNGDRASCENHVLTFTQIRTMSDKIMIKWKPFWP--SDFRDLLGFMVLYKEAPFQNVTEFDGQDACGSNSWVIADVDPPRRASEGEKDQTEPGHLIMPLKPWTQYAIMVKTQLSASDEHQVNGAKSEIIYVRTNATRPSVPLDPISSSNSSSQIILKWKPPNDPNGNITHYLVFYQR-QPEASELYKFDYCQKGMKLPSRVPTQVDSGEEKKWNQTEEEGQGKQCCTCPKTDKELKKEK------EDSEYRKTFENYL------HNEV------------FEIKRPRQRRSAMGVANQTLPFLTTAPSPTGIPDEDEKTFESTKTVVTVHAKESTV-ISNLRHFTSYQIEIHAC----------NKAIPT-----------CSMAAFVSARTMPEEKADDI-LGPIRSEVTENTVHIEWQEPATPNGIIILYEVIYKRLVDSEDLHY----CVSRKMY-------------------KKMHGCKLKVMHPGNYSVKIRATSLAGNGSWTQPSFFYVQDLSDPLYVVKIIIGPIICFVLLLLVSVAGFVVFKKNQTQGPSGPIYASSNPEYLSANDVYEEDEWEVPRDKIHILR---ELGQGSFGMVYEGLAKDIVK----------GEGETHVAVKTVNESASLRERIEFLNEASVMKAFTCHHVVRLLG 1095          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LV+MELM  GDL  YLR    + E         L      A +IADGM YL+  KFVHRDLAARNCM+   L +KIGDFGM RD+Y   YYRK  KG LPVRWMAPESL  G F+  SD WS+GV+LWEI TLA  PY+G+S+  V+++V +GG L      N    L  +M+ CW YNP  RP+F +II+ L      +F+  S++
Sbjct: 1104 LVVMELMTHGDLKSYLRSLRPDAENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMEGGFL--DRPENCPDRLHNLMQMCWQYNPKMRPAFQEIIEMLRDDLHPSFQEVSFF 1308          

Query:  222 KVCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTS--------EYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINW---TSIVRQHGAPI--KLINMRNFCLEFCPNN--CPRGE---NLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCY-GEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCGRVLIHSINDFSEAEGCYSIED-IYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTVEGYIGK------PVVIDNLLPAKRYAFYAEAIRSRVEN---WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRS----LEIFGDDFFMEDVCFTXXXXXXX-XXXXXXXXXXKTNNGNQNQGE-CDCDKCMESCNKNQILINIDKDDTI-MQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANE-----TYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTR---VNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKK-----YLERTRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +VC+S+DIR   S   +L NCTV+EG L+I +++  +          SFP L  IT  L+++ V G ++L   FPNL++IRG+ L YNYA+VI E T+L  IGL NLR +  G VR+  N  LCY+++++W   T +V  +   +  KL    N C     N+  CPR      L   CW  N CQ VC + C          D  +CCH +CLGGC     D  C  C +   N RCV  C    YK++  RCI+   C      S T      H+ I    C+  C     +NK     C  C   C  K+C   +I S++     +GC  I   + I+I+ G +  S+ L      +  ++  ++I  S ++ SL FLRSLR I G    +N             F   +N++L  ++D     +Q N+TI  G + F  N KLC  +I       +  KT ++   E     +NG+ A C  E  I+++ +   SS+T+K   +   +      +  +   KE+  +N+++++  + C   +W  V+  + +       V + +L P  +YA +  AI  +VE+       SD+IY+ T   +PS P +      SS+++ + W+ P+FPNG +T Y++ ++      E++  ++  +D+      S       +   + +K++     +G  C C K  E  ++       +KDD + ++  + Y+               +P D    ++  V  N         T FP       S    EN T+    +++ P +E      Y +  +L  +T Y  +I AC +   +                     C + + + A T P    D+I    +  R   V G  V + W EP  PNG +L Y ++YR                T PE         K+   S    +Q  G   L  L PG Y  +++  ++A  G+WT+S +F +       +   Y  I   +I+ +  A  + + ++  KK           + S NP+Y     +Y  D WE+ R+ + M   +  LG+GSFGMVY+G+ K +            DE +  VA+KT+N ++++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   35 EVCESMDIRNDISEFKVLENCTVVEGYLHILLISKKTTNNVEALRSLSFPKLTVITDHLLLFRVAGLESLSTLFPNLSVIRGRNLFYNYALVIYEMTSLKDIGLYNLRNITRGAVRVAKNSELCYLDSVDWSLITDVVFNNVFDLNKKLEECDNVCPGIMKNSPLCPRTSYTNKLDYRCWSSNHCQKVCPDQCK-----LACTDDGQCCHSQCLGGCSEPNSDRACSVCLHYFHNERCVPDCPPGTYKFEGWRCITFEMCSQAHLPSDT------HFVIHGGECMPDCPSDFTRNKTNPMLCTACNGPCD-KFCTSPVIDSVDAAQTLKGCTVINGHLDINIRRGDNIASE-LENFMGLIRTVKGYVKIRHSHALGSLSFLRSLRYINGEELIENTYS----------FFAINNQHLQSLWD----WSQHNLTIRAGRLFFRQNPKLCMSEI-----HKMWEKTGITVKPEGGDFRNNGEKASC--ESHILKIKSNVTSSYTIKLTWERYQVPEYGGLINFIVFYKESPFQNITEFDGQDGCGSNSWHMVDVDLSQDEKLDPKVTLQHLNPWTQYAIFVRAITLQVEDKHITGAKSDIIYIRTRPSSPSVPKDAHAYANSSTKLLVKWSRPVFPNGNLTYYLVRWQQQPEDRELYQHNYCSKDLKIPIRVSAGGFSDVEDGAKPTKSDLSGAKKGPCCTCQKTAEEKDR-------EKDDRVFIKMFENYLHNIVFYA--------RPPDRQRRDVVGVANN---------TLFPDGAQGNASLSPAENGTDGVPPVIEYPFSEEKVSTEYLEIPSLQPFTVYRIDIHACNEEVGL---------------------CGAGAFVFARTKPASEADDIPGKVVPERSDKVEGCMV-LHWPEPVVPNGLVLMYEVKYR--------------LGTEPE---------KHGCVSRRQYRQNRG-ARLTHLSPGNYSARVRAISLAGNGSWTESIYFYVPPPKRDDDVTFYLSIIIPIIVTLFIASLITILFFINKKRNSNRLGNGVLYASVNPEYISAAEMYTPDEWEVAREKITM---HKELGQGSFGMVYEGLAKGVVK----------DEPETRVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLG 1069          

Query: 3759 LVIMELMEFGDLAGYLRK---QGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  +LR    +    +      +    A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI TL+  PY+GMS+  V+++V +GG L      N   +L  +M  CW YNP  RP+F +II  ++   D +FR  S++
Sbjct: 1078 LVIMELMTRGDLKSHLRSLRNENSNSQVLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTMSDVWSFGVVLWEIATLSEQPYQGMSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPTFLEIINTIKDDLDPSFREVSFF 1280          

Query:  225 VCQSIDIRKR-SHVSLLTNCTVIEGDLYIAMVTLTS--------EYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINW---TSIVRQHGAPI--KLINMRNFCLEFCPNN--CPRGE---NLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCY-GEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGR-CEICGSECSKKYCGRVLIHSINDFSEAEGCYSIED-IYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTVEGYIGK------PVVIDNLLPAKRYAFYAEAIRSRVEN---WLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRS----LEIFGDDFFMEDVCFTXXXXXXX-XXXXXXXXXXKTNNGNQNQGE-CDCDKCMESCNKNQILINIDKDDTI-MQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANE-----TYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTR---VNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSI-FTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLER----TRWVSSNPDYWI---IYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +C+S+DIR   S   +L NCTV+EG L+I +++  +          SFP L  IT  L+++ V G ++L   FPNL++IRG+ L YNYA+VI E T+L  IGL NLR +  G VR+  N  LCY+++++W   T +V  +   +  KL    N C     N+  CPR      L   CW  N CQ VC + C          D  +CCH +CLGGC     D  C  C +   N RCV  C    YK++  RCI+   C      S T      H+ I    C+  C     +NK     C  C   C  K+C   +I S++     +GC  I   + I+I+ G +  S+ L      +  ++  ++I  S ++ SL FLRSLR I G    +N             F   +N++L  ++D     +Q N+TI  G + F  N KLC  +I       +  KT ++   E     +NG+ A C  E  I+++ +   SS+T+K   +   +      +  +   KE+  +N+++++  + C   +W  V+  + +       V + +L P  +YA +  AI  +VE+       SD+IY+ T   +PS P +      SS+++ + W+ P+FPNG +T Y++ ++      E++  ++  +D+      S       +   + +K++     +G  C C K  E  ++       +KDD + ++  + Y+            S  +P D    ++  V  N         T FP       S    EN T+    +++ P +E      Y +  +L  +T Y  +I AC +   +                     C + + + A T P    D+I    +  R   V G  V + W EP  PNG +L Y ++YR       L      CV+R ++                  +Q  G   L  L PG Y  +++  ++A  G+WT+S +F +      FT   N + +  +        L  ++ +  KK+   R      + S NP+Y     +Y  D WE+ R+ + M   +  LG+GSFGMVY+G+ K +            DE +  VA+KT+N ++++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   22 ICESMDIRNDISEFKVLENCTVVEGYLHILLISKKTTNNVEALRSLSFPKLTVITDHLLLFRVAGLESLSTLFPNLSVIRGRNLFYNYALVIYEMTSLKDIGLYNLRNITRGAVRVAKNSELCYLDSVDWSLITDVVFNNVFDLNKKLEECDNVCPGIMKNSPLCPRTSYTNKLDYRCWSSNHCQKVCPDQCK-----LACTDDGQCCHSQCLGGCSEPNSDRACSVCLHYFHNERCVPDCPPGTYKFEGWRCITFEMCSQAHLPSDT------HFVIHGGECMPDCPSDFTRNKTNPMLCTACNGPCD-KFCTSPVIDSVDAAQTLKGCTVINGHLDINIRRGDNIASE-LENFMGLIRTVKGYVKIRHSHALGSLSFLRSLRYINGEELIENTYS----------FFAINNQHLQSLWD----WSQHNLTIRAGRLFFRQNPKLCMSEI-----HKMWEKTGITVKPEGGDFRNNGEKASC--ESHILKIKSNVTSSYTIKLTWERYQVPEYGGLINFIVFYKESPFQNITEFDGQDGCGSNSWHMVDVDLSQDEKLDPKVTLQHLNPWTQYAIFVRAITLQVEDKHITGAKSDIIYIRTRPSSPSVPKDAHAYANSSTKLLVKWSRPVFPNGNLTYYLVRWQQQPEDRELYQHNYCSKDLKIPIRVSAGGFSDVEDGAKPTKSDLSGAKKGPCCTCQKTAEEKDR-------EKDDRVFIKMFENYLHNICFYV-----SFSRPPDRQRRDVVGVANN---------TLFPDGAQGNASLSPAENGTDGVPPVIEYPFSEEKVSTEYLEIPSLQPFTVYRIDIHACNEEVGL---------------------CGAGAFVFARTKPASEADDIPGKVVPERSDKVEGCMV-LHWPEPVVPNGLVLMYEVKYR-------LGTEKHGCVSRRQY------------------RQNRG-ARLTHLSPGNYSARVRAISLAGNGSWTESIYFYVPPPKPQFT--INVWFLFLIPTGDDDVTLITILFFINKKRNSNRLGNGVLYASVNPEYISAAEMYTPDEWEVAREKITM---HKELGQGSFGMVYEGLAKGVVK----------DEPETRVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLG 1054          

Query: 3759 LVIMELMEFGDLAGYLRK---QGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYY 4364
            LVIMELM  GDL  +LR    +    +      +    A +IADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+  SD+WS+GV+LWEI TL+  PY+GMS+  V+++V +GG L      N   +L  +M  CW YNP  RP+F +II  ++   D +FR  S++
Sbjct: 1063 LVIMELMTRGDLKSHLRSLRNENSNSQVLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTMSDVWSFGVVLWEIATLSEQPYQGMSNEQVLRFVMEGGLLDKPD--NCPDMLFELMRMCWQYNPKMRPTFLEIINTIKDDLDPSFREVSFF 1265          

Query:  186 ITFTDSFKLSNEKVC-QSIDIRKR-SHVSLLTNCTVIEGDLYIAMV---------TLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKE-TNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQH-----GAPIKLINMRNFCLEFCPNN--CPRGENLQKY---CWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYG-EGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITG-RCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIE-DIYISIKEGGSSLSDILMKAFSKL-TIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHS-KVPDISLQNSALTALFMLKETT-KNVSQYELFNSCSEQNWRTVEGYIGKP-------VVIDNLLPAKRYAFYAEAIRSRVENWL---EISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYII-WYRSLEIFGDDFFMEDVCF------TXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEY-NQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTR----------WVSSNPDYWIIYEI---DVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            +  +   + +  K+C  SIDI    +   LL NCTV+EG L I ++          +    SFP L  IT  L+++ V G  +L   FPNLT+IRG+ L YNYA+VI E T+L  IGL NLR +  G +RI+ NP LCY+++I+W+SI+            +     + CL    NN  C +      Y   CW+ N CQ  C  SC +  + C      +CCHP+CLG C   + D  C +C +    GRC+  C    Y+++  RCIS   C      S   +   D + I    C+ +C  G  ++      C  C   C K   G+V I S++     +GC  I+ +++I+I+ G + +++  +++F+ L   +   +RI  S ++TSL FLRSLR I          +          F  +DN+ L  ++D K    Q N+TI  G + F  N KLC  +I       + TKT + +  +     +NGD A C+   L  +  +   +   +     + PD       ++ +   KE   +N++++E  + C   +W  V+  + +P       V++  L P  +YA + +A+   VE+       S V+Y+ T    P+ P +++  + SS+++ + W PP+ PNG  T Y+I W +  E    + F  + C        +  ++     +   + +K++    N+G C    C+  C K+  ++  +  D   +     + ++F+  +              F I    Y  +   +     + P       S  +     +   + ++    E   + + L  +T Y  ++ AC    N Q  E                 CS+   + + T P E  D++    +    +   V + W EP  PNG IL Y I+Y K   E+E       CV+R                   + Q + G   L +L PG Y  +++  ++A  G+WT    F ++          Y      ++ + +  + ++ C       L R R          + S NP+Y+   E+   D WE+ R+ + +      LG+GSFGMVY+GV K +            DE +  VAVKT+N ++++ ER EF+NEA  MK+F  +H+V+L G
Sbjct:   18 LALSSCLRPATAKICGPSIDIGNDINEFRLLENCTVVEGYLQILLIGDKNNNANQEVFRSLSFPKLTMITDYLLLFRVSGLDSLSTLFPNLTVIRGRNLFYNYALVIFEMTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSIDWSSIMDAEFNNYIAGNKQSKECSDVCLGVTENNPLCRKAMIRNSYSYHCWNSNQCQKECPPSCGR--RACTAE--GKCCHPQCLGSCTAPDSDAACAACVHYFHQGRCMADCPPGTYRFEGWRCISAKVC------SKVHHPDFDTFVIHGGECMPECPSGYTRSATNSMHCTACDGLCDKVCDGKV-IDSMDAAQSLKGCTVIKGNLHINIRRGHNMVAE--LESFTGLIQRVTGYVRITHSHTLTSLAFLRSLRYI----------DGETLLEDMYAFSAFDNQQLQYLWDWK----QHNLTIKTGKLFFRANPKLCMSEI-----RKMWTKTGIREHFQETDFRNNGDRASCESTILRFKSNSTQSTRIILTWERYRPPDY---RDLISFIVYYKEAPFQNITEFEGQDGCGSNSWNMVDVEL-RPEKDSDPGVLLSGLKPWTQYAIFVKAVTLMVEDKFMPGAKSKVVYIRTSPSPPTMPRDVRAYSNSSTQLVVRWLPPVSPNGNRTYYLIRWQQQAE--DRELFQHNYCSKELKIPVRIAARGVGDQEEETKPTKSDTEGANKGPC----CL--CPKSPEVLEAEAADASYR----KVFENFLHNSIFTPRPADRRRRDVFGIANSTYAGRHKSLSNTSADPPPHTAGNSSGAAEPEPADQEYEFLEQSVTERELQISGLQPFTVYRVDVHAC----NRQVKE-----------------CSAAEFVFSRTKPAEKADDV-PGPVTWEGHKDWVFLRWPEPSHPNGLILLYEIKY-KLAAESE----KHECVSR------------------QLYQTQQGV-RLTNLSPGNYSVRVRATSLAGNGSWTPPLDFYVA--------ERYESALYAMVFVPIIIVILISCMVVMLVALNRKRNSDRLGNGVLYASVNPEYFSAAEMYVPDEWEVAREKITLCR---ELGQGSFGMVYEGVAKGVVK----------DEPETKVAVKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLG 1069          

Query: 3759 LVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHL-----WAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFR 4349
            LVIMELM  GDL  YLR    + + + S +   L      A QIADGM YL+  KFVHRDLAARNCM+     +KIGDFGM RD+Y   YYRK  KG LPVRWM+PESL  G F+ +SD+WS+GV+LWEI TLA  PY+G+S+  V+++V +GG L      N   +L  +M  CW YNP  RPSF +II  ++   D +F+
Sbjct: 1078 LVIMELMTRGDLKSYLRSLRPKEQQWSSLSLPPLKKMLQMAGQIADGMAYLNSNKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLEKPQ--NCPDMLFELMRMCWQYNPKMRPSFVEIIGSVKDELDPSFK 1277          

Query:  111 MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYXXXXXXXXXXXXXXLLATRLESENSTKNFIQDS 4463
            MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTN P+TDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNI+AKNSSNSTNI QQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYFQKQQTDFQTQEQDLLATRLESENST NFIQDS
Sbjct:    1 MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNLPATDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIMAKNSSNSTNIIQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYFQKQQTDFQTQEQDLLATRLESENSTNNFIQDS 1451          

Query:  111 MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYXXXXXXXXXXXXXXLLATRLESENSTKNFIQDS 4463
            MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTN P+TDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNI+AKNSSNSTNI QQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKG       FGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYFQKQQTDFQTQEQDLLATRLESENST NFIQDS
Sbjct:    1 MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNLPATDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIMAKNSSNSTNIIQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKG-------FGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYFQKQQTDFQTQEQDLLATRLESENSTNNFIQDS 1444          

Query:  111 MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLL 4247
            MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTN P+TDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNI+AKNSSNSTNI QQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLL
Sbjct:    1 MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNLPATDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIMAKNSSNSTNIIQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLL 1379          

Query:  111 MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNFPSTDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGXXXXXXXXXXXXXGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYXXXXXXXXXXXXXXLLATRLESENSTKNFIQDS 4463
            MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTN P+TDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNI+AKNSSNSTNI QQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHR       ++  +L +                        LP R M+   ++  Y SK                                    GGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYFQKQQTDFQTQEQDLLATRLESENST NFIQDS
Sbjct:    1 MNFRKSLKYFLKISLIFNIINLYQAITFTDSFKLSNEKVCQSIDIRKRSHVSLLTNCTVIEGDLYIAMVTLTSEYSFPTLKEITGSLVIYYVKGTKTLGLYFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSIVRQHGAPIKLINMRNFCLEFCPNNCPRGENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITGRCEICGSECSKKYCGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIKGNSANKNNNETTNGSNKSIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNSCSEQNWRTVEGYIGKPVVIDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFMEDVCFTKSKSQRRIQSQSNNRISKTNNGNQNQGECDCDKCMESCNKNQILINIDKDDTIMQFLDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYNQTVRVDEVVTNLPATDISTISKPSIENLTNHFKKMVQVPANETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNINESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIMAKNSSNSTNIIQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYFIIGAVVIIIILCALFVLVCYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYGIVSKVNNSKISKKGYRRKFKCFGHSVMSRVKCPLNWNSLNRINILKLFDSKASEIKERQIDDIAAAQFGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGEGFVSENQSHLWAIQIADGMLYLSEMKFVHRSYGV---ILWEILTL----------------------ASLPYRGMSHHDVIQ-YVSK------------------------------------GGSLLSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNFRNNSYYFQKQQTDFQTQEQDLLATRLESENSTNNFIQDS 1389          

Query:  279 CTVIEGDLYIAMVT--LTSEYSFPTLKEITGSLVIYYVKGTKTLGL-YFPNLTIIRGQTLAYNYAVVIKETNLLYIGLVNLRLVMFGGVRIDNNPSLCYVNTINWTSI------VRQHGAPIKLINMRNFCLEFCPNNCPR---GENLQKYCWHHNTCQNVCSESCAKNNQYCFMNDPNRCCHPECLGGCYGEGDEMCVSCKNVLSNGRCVKKCDKFFYKYKNRRCISESECMNLSSQSSTDYRREDHYAIEDDACVKQCSPGKQQNKITG-RCEICGSECSKKY---CGRVLIHSINDFSEAEGCYSIEDIYISIKEGGSSLSDILMKAFSKLTIIENSLRIVKSSSITSLDFLRSLRIIXXXXXXXXXXXXXXXXXXXIVFEVYDNENLVEIFDEKVALNQLNITILEGSVSFNLNRKLCPEKILSFLNSNVQTKTKLSKLDERIINVSNGDMAFCKHEKLIVQVLNISDSSFTVKCHSKVPDISLQNSALTALFMLKETTKNVSQYELFNS-CSEQNWRTVE--------GYIGKPVV-------------IDNLLPAKRYAFYAEAIRSRVENWLEISDVIYLTTERKNPSQPINLKTETLSSSEIRLTWNPPLFPNGEVTRYIIWYRSLEIFGDDFFME--DVCFTXXXXXXXXXXXXXXXXXKTNNGNQNQGECD-CDKCMESCNKNQILINIDKDDTIMQF--LDEYITKSFIKQNEIPKSNWKPVDSGHFEIKKVEYN-QTVRVDEVVTNFP-STDISTISKPS------IENLTNHFKKMVQVPAN----ETYFKFTNLHHYTEYFFEIQACQDLQNVQSSESKALSKNGTSKNVLNLPCSSKSLISAHTSPKENMDNI----NESTINTRVNGSSVKIFWSEPKSPNGFILNYFIRYRKYPYEAELDWLSTPCVTRPEWLNGTNIVAKNSSNSTNINQQKSGFYTLRDLKPGKYEFQIKPFAIATEGAWTKSYHFKISSDSIFTEYRNYXXXXXXXXXXXXXXXXXXXXYYCKKKYLERTRWVSSNPDYWIIYEIDVWEIDRKDVDMLEWNYPLGRGSFGMVYKGVLKNLTTPARDKYLRTLDEKQMFVAVKTLNTNSTILERREFINEACYMKQFQSYHLVKLYG 3509
            CT++EG + I  ++  + +   FP L+E+T  +++ +   +    L  FPNL +IRG  L    A+++      ++   +LR +  G V +  N +LC V  I+W  I        +    + +   +  C   C N CP     +   + CW +NTCQ++C   C+  + YC +N+ + CCH +CLGGCYG+ ++ CV+CK +     CV  C   +Y++K  RC+ + EC           ++        + CVK+C      + I G +  + GS  + KY   CG + + S  D  + + CYS E + IS++ GG  LS  L   F  L I++  ++I++S+ + SL FL  L  I                  ++  ++  N  L +++            IL GSV F  NR LC   I +F+N   +   + S  D+ +I+ +NG +A C   +L + V+ +   S  V+ + K    S     L+ L   +  + N+      +S CS   W  +E        G   KP               I +L PA  Y  Y E  R   ++   IS+ ++ TT  + PS P  +++ + + +EIRL+W PPL PNG +T+YII+Y    +F + F  E  +  F +S++    ++  +N    TN+  Q Q  CD C  C ++C +N       K + +++    D ++    + Q +  K+N   + S         YN +++ +    T  P +  +S + KP+      +EN ++   K +++PA+    + Y   TNL ++TEY  EI AC   Q+  +   + L K   +       CS+++  S  T    ++D I    +++ +N       + + W  P   NG IL Y + YR           +  C+      +  N+ AKNSS  +         + +R+   G YEFQI    +A  G W+    F+    ++  +Y       + V I+ +  + +L+ Y   KK     R++ +  +++ +   D W I+ +DV +L    P+G+G+FG+VY G LK L +PA+  ++       M VAVKT++  +TI +  +F++EAC MKQF  YH+V L G
Sbjct:   10 CTIVEGKVVITHLSKHMCNSLRFPVLREVTDYILLAFSSCSDDTSLNIFPNLMVIRGYELLQGCALIVYYNAWRHLNFTSLRSIASGNVLVALNSNLCNVGNIDWKYINDNRDEASKSTKKLYIKTNKFICSNSCSNMCPERTIDDQKTRVCWSYNTCQSICDSICSSKDLYCHVNNTSICCHKQCLGGCYGKTNKDCVACKKLRYKEECVLSCPVGYYEFKGSRCVHKIECS----------KKNMSITFNPNRCVKECPSDLFASFINGTKYCVNGSTITTKYNKECGLLFLKSFKDLDQVKNCYSAERVIISLQIGGRDLSLKLRDVFKNLRIVKQFIQIMRSNFLESLTFLNPLLEI---------QGQAFIGQTNVTLDITANNILSKLWTPDPKFR-----ILSGSVRFLANRNLCKTFIHNFIN---KIGLQNSLFDKELIDSTNGHIAICTFIQLNLTVVEV--KSQCVRLYWKNKQTS-NYQILSGLTYYRSISTNMKNGGFSDSGCSSVIWSVIEAQCKNNDSGVKLKPTSLWPQDGGEEFICEISSLKPATSYQVYLE-FRFTRQDSAAISNHVFFTTSTEMPSPPQIIESISSAHNEIRLSWKPPLHPNGLITKYIIYYWKNALFENSFNNEYSNKDFCQSETNTGFKTSQSNFEKATNDNFQPQAMCDTCSICKKTCERNP-----QKQEELLEMTRFDTHMHSVILVQRK--KNNPNSLSS---------YNSKSIAIPNNFTTMPLNATVSVVHKPTPKSNIPMENTSSINVKQIEIPASALKTQYYHVITNLDYFTEYLIEIVACHQRQSNFNYSQQILMKFSMND------CSNRASTSTRTERSPDVDVIPPIYDKTYMNITGINKEITVTWKIPPKVNGLILFYQLNYRIKKDNVIFQAWTPNCINSKSITSIKNLHAKNSSYQS---------FIIRNPFSGTYEFQIMIRTLAGNGNWSPLESFEYKETNVDVDYVLKITFSSTVFIMAVALISILIWYLAWKK---NQRYILTRNNHYFLSGQDEWNIEFQDVKLL---LPIGKGNFGVVYSGELKKLESPAKSIFVNA--SLPMKVAVKTVSQAATIEDIVQFLSEACLMKQFLGYHIVHLIG 1075          

Query: 3711 FGSFKATISQHFDKMPLVIMELMEFGDLAGYLRKQGEEGE-GFVSENQSHLWAIQIADGMLYLSEMKFVHRDLAARNCMINSLLIIKIGDFGMARDVYYDCYYRKENKGRLPVRWMAPESLLSGYFSKSSDLWSYGVILWEILTLASLPYRGMSHHDVIQYVSKGGSL-LSTGSFNSSKLLLGIMENCWLYNPDDRPSFFDIIQKLELYADMNF 4346
             G +   I ++    PLV+MELME GDL+ YL +  E  + G +   QS LWAIQIADGM YL+  +FVHRDLAARNC++++ L IKIGDFG+ + +  + YYRK  + + PVRWMAPESL S  ++  +D+WSYGV+L+EI TL SLPY GMSH  VI++V  GG L L      SS  LL +M  CW +   DRP+F  I++ L  Y +  F
Sbjct: 1074 IGIYAGNIQKNSSLYPLVVMELMENGDLSNYLHQYAERSDKGMIDGKQSLLWAIQIADGMCYLACKRFVHRDLAARNCLVDADLNIKIGDFGLTKSINENDYYRKRGRAKAPVRWMAPESLRSAVYTTKTDVWSYGVVLYEISTLGSLPYSGMSHESVIEFVRDGGKLDLDDLKIPSS--LLDVMTWCWSFYDTDRPTFMRILEYLVPYVNNEF 1285