Mitogen-activated protein kinase kinase kinase 3

Overview


Name	Mitogen-activated protein kinase kinase kinase 3
Smed ID	SMED30018153
Length (bp)	2131

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Mitogen-activated protein kinase kinase kinase 3 (SMED30018153) t-SNE clustered cells

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase kinase 3 (SMED30018153) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mitogen-activated protein kinase kinase kinase 3 (SMED30018153) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30018153

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
nervous system	SMED30018153	SMESG000016712.1	dd_Smed_v4_8526_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30018153	SMESG000016712.1	dd_Smed_v4_8526_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 139.813 bits (351), Expect = 5.458e-34
Identity = 83/256 (32.42%), Postives = 145/256 (56.64%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ +++ RP+AE+
Sbjct:  389 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK-NLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL-RRIFVEARQRPSAEE 642

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 139.428 bits (350), Expect = 5.774e-34
Identity = 83/256 (32.42%), Postives = 145/256 (56.64%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ +++ RP+AE+
Sbjct:  358 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK-NLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL-RRIFVEARQRPSAEE 611

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 139.813 bits (351), Expect = 5.842e-34
Identity = 83/256 (32.42%), Postives = 146/256 (57.03%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I +  + L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ +++ RP+AE+
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEI-QLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL-RRIFVEARQRPSAEE 615

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 139.813 bits (351), Expect = 5.967e-34
Identity = 83/256 (32.42%), Postives = 145/256 (56.64%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ +++ RP+AE+
Sbjct:  393 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK-NLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL-RRIFVEARQRPSAEE 646

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 139.813 bits (351), Expect = 5.967e-34
Identity = 83/256 (32.42%), Postives = 145/256 (56.64%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ +++ RP+AE+
Sbjct:  393 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK-NLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL-RRIFVEARQRPSAEE 646

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 124.405 bits (311), Expect = 2.433e-29
Identity = 83/262 (31.68%), Postives = 133/262 (50.76%), Query Frame = 1

Query: 1063 FCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKL-----CHPR-IIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSN-SYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPF------GKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTA 1809
            F + KL P    E  F K E IG+G+FGEV+K     + +   IK I    ++  E+ I   ++++     C  + + +YFGS      L I MEYL  GS  DL + G  L E       ++I++GL +LH    IHRDIK  N+L+    ++K+ADFG++ +L       I+  G+ ++ APE+  +  Y Y  D+W++GIT ++++  +   S L P        K+   ++  S  S+  K F    L  D + RP+A
Sbjct:    3 FANSKLDP----EVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKII---DLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGK-LDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSA 256

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 122.094 bits (305), Expect = 1.230e-28
Identity = 83/268 (30.97%), Postives = 135/268 (50.37%), Query Frame = 1

Query: 1045 NLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKL-----CHPR-IIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSN-SYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPF------GKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTA 1809
            ++K +     KL P    E  F K E IG+G+FGEV+K     + +   IK I    ++  E+ I   ++++     C  + + +YFGS      L I MEYL  GS  DL + G  L E       ++I++GL +LH    IHRDIK  N+L+    ++K+ADFG++ +L       I+  G+ ++ APE+  +  Y Y  D+W++GIT ++++  +   S L P        K+   ++  S  S+  K F    L  D + RP+A
Sbjct:   17 SMKWDRIYIQKLDP----EVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKII---DLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGK-LDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSA 276

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 121.324 bits (303), Expect = 2.388e-28
Identity = 79/250 (31.60%), Postives = 128/250 (51.20%), Query Frame = 1

Query: 1099 EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKL-----CHPR-IIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSN-SYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPF------GKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTA 1809
            E  F K E IG+G+FGEV+K     + +   IK I    ++  E+ I   ++++     C  + + +YFGS      L I MEYL  GS  DL + G  L E       ++I++GL +LH    IHRDIK  N+L+    ++K+ADFG++ +L       I+  G+ ++ APE+  +  Y Y  D+W++GIT ++++  +   S L P        K+   ++  S  S+  K F    L  D + RP+A
Sbjct:   16 EVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKII---DLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGK-LDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSA 261

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 120.939 bits (302), Expect = 5.035e-28
Identity = 79/250 (31.60%), Postives = 128/250 (51.20%), Query Frame = 1

Query: 1099 EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKL-----CHPR-IIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSN-SYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPF------GKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTA 1809
            E  F K E IG+G+FGEV+K     + +   IK I    ++  E+ I   ++++     C  + + +YFGS      L I MEYL  GS  DL + G  L E       ++I++GL +LH    IHRDIK  N+L+    ++K+ADFG++ +L       I+  G+ ++ APE+  +  Y Y  D+W++GIT ++++  +   S L P        K+   ++  S  S+  K F    L  D + RP+A
Sbjct:  181 EVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKII---DLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGK-LDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSA 426

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Match: gck-2 (Mitogen-activated protein kinase kinase kinase kinase [Source:UniProtKB/TrEMBL;Acc:Q23290])

HSP 1 Score: 119.398 bits (298), Expect = 1.633e-27
Identity = 70/194 (36.08%), Postives = 103/194 (53.09%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI---SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSN-SYAISLTGTVYYFAPEIWSEQR---YKYPTDLWAVGITILDMS 1668
            +E  + +G G +GEV+K     S+    +K +   + +    I+  I   RE   HP II YFGS      L I MEY   GSL D+  L  PL EL+     ++ + GL +LH    IHRDIK  NILL +S ++KLADFG++ ++ +      S  GT Y+ APE+   ++   Y    D+WA GIT +++ 
Sbjct:   15 YELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFAVIQQEIMVIRE-CSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKIHRDIKGANILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMQCDVWATGITAIELG 207

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: GckIII (gene:FBgn0266465 transcript:FBtr0083399)

HSP 1 Score: 127.487 bits (319), Expect = 3.013e-30
Identity = 84/269 (31.23%), Postives = 141/269 (52.42%), Query Frame = 1

Query: 1099 EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLC------HPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSREL-NSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG-----KDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQINRFLRYFID 1857
            E  F K E IGKG+FGEVFK     + +   IK I    ++  E+ I+  ++++        P + +Y+GS      L I MEYL  GS  DL++ G+   E+      +++++GL +LH    +HRDIK  N+LL    ++KLADFG++ +L N+ S   +  GT ++ APE+  + +Y    D+W++GIT ++++  +   S+L P          N    + + ++  K F  + L  D + RPTA++     FI+  +   Y ID
Sbjct:   10 ELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKII---DLEEAEDEIDDIQQEIMVLSQCDSPYVTKYYGSFLKGTKLWIIMEYLGGGSALDLMKAGS-FEEMHIGIILREVLKGLDYLHSERKLHRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENRPTAKELLKYPFIKKAKKNAYLID 274

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: Ank2 (gene:FBgn0261788 transcript:FBtr0334061)

HSP 1 Score: 125.176 bits (313), Expect = 4.945e-29
Identity = 71/251 (28.29%), Postives = 126/251 (50.20%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLI-KQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEE 1011
             PL  AC+K   K+ + L+  G  I A  E     +H A     ++IV +L+  + + +   V+ + P+H + +     II+IL+ N   ++AR      P+H A+   +V ++ +L++ G  ++A  K    ++HIAAK G  +V  VL+EN   ++A  +     +H  A+YG IK+ +LL+ K+ D++A  K+    +H AC  N  +V  LL +            + P+ I+  K  ++I   L E
Sbjct:  522 TPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLE 772

HSP 2 Score: 104.375 bits (259), Expect = 1.539e-22
Identity = 63/282 (22.34%), Postives = 123/282 (43.62%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHI---------------------------------AAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLL 1005
             PL  A   G  ++   L++ G  I AK +     +H A +  HVD  + L+     ++   V     +H +    + ++ K+L+  + +  AR  N + P+H A  KN +KV+ +L++ G +I A  +  +  +H+                                 AA++   D++R+LL N   ++AR R  +  +H A++ G + I+ LL++    ++A  KD   A+H A      EV  +L +    +D      + P+ ++     +++  LL
Sbjct:  423 TPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLL 704

HSP 3 Score: 95.1301 bits (235), Expect = 1.202e-19
Identity = 58/249 (23.29%), Postives = 113/249 (45.38%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIK-QCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLL 1005
             PL  A   G+  +   L+  G  ++A  +    A+H A K    ++   LI +   L+A   K   P+H + K  + ++ ++L+  + +++A+ +N   P+H A H N+ +V  +L++ G +  A  K     +HIAA+   +D+   LLE      A  +     +H ++Q G  +I  LLI+ +  +    K+    +H     + + V ++L K    +D      Y P+ ++       +V  L
Sbjct:  621 TPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFL 869

HSP 4 Score: 93.5893 bits (231), Expect = 3.551e-19
Identity = 54/226 (23.89%), Postives = 116/226 (51.33%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRP-IHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDD 933
             PL  A ++    + + L+ +G +     E     +  A ++ H  +V  L+ S+        K++ P +H + K+++ +   +L+ ND N +   ++ + P+H A+H  +  + ++LI+ G ++    K N+  +H+AAK G  +++ +LLE   NIEA+ R     +H AA+ G  +++++L+++   I A  K+    +H A     ++  ++L   +  VD+
Sbjct:  262 TPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTR-----GKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDE 482

HSP 5 Score: 85.5001 bits (210), Expect = 9.987e-17
Identity = 57/316 (18.04%), Postives = 132/316 (41.77%), Query Frame = 1

Query:  277 ACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIA---------------------------------AKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGE 1122
            A ++G  ++A  LI++G  ++A  +K    +H   K  H+ + + L+  E +++A       P+H +C   N Q+  +L+    +  A  +N   P+H A  KN + + + L++ G    A +K     +H++                                 A+  NV+V  +L +N  NI+   +     +H A+ +G+  ++  L++   +++A        +H         ++ LL + +   + +      P+ I+R    + +++ L+     +  + A +   E++    + P++++E      E
Sbjct:  659 AAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSLKTITKEDETAAAPSQAEEKY--RVVAPEAMHESFMSDSE 972

HSP 6 Score: 84.7297 bits (208), Expect = 1.670e-16
Identity = 65/282 (23.05%), Postives = 118/282 (41.84%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWA----CLN-----------------------------NFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLL 1005
             PL  A   G+  +A  LI  G D+    +     +H A K    ++V  L+    N+EA       P+H + +  + Q++ +L+     I A+ +N   P+H A     V    +L+     ++      + ++H+AA  G+V V ++LL+ N +  AR       +H A +  ++K++ELL++    I A  +     +H A    C+N                             N  ++I++L +   +VD R      P+ I+     V+IV LL
Sbjct:  357 TPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLL 638

HSP 7 Score: 70.0922 bits (170), Expect = 5.693e-12
Identity = 54/278 (19.42%), Postives = 113/278 (40.65%), Query Frame = 1

Query:  268 LINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCN-----------------------------IEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLI-KQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEE 1011
             + A   G+ +     + +  DI   +     A+H A K  H+ +V  L+     +++   K    +H +      +++K+L+ ++ ++  + +N + P++ A  +N   V+ +L+  G N                              + R K  + ++HIAAK  +V    +LL+N+ N +   +     +H A+ YG   I  LLI K  D+    K     +H A       ++ LL +    ++ +      P+  +      ++V++L E
Sbjct:  165 FLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLE 442

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: Ank2 (gene:FBgn0261788 transcript:FBtr0303119)

HSP 1 Score: 124.79 bits (312), Expect = 5.387e-29
Identity = 71/251 (28.29%), Postives = 126/251 (50.20%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLI-KQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEE 1011
             PL  AC+K   K+ + L+  G  I A  E     +H A     ++IV +L+  + + +   V+ + P+H + +     II+IL+ N   ++AR      P+H A+   +V ++ +L++ G  ++A  K    ++HIAAK G  +V  VL+EN   ++A  +     +H  A+YG IK+ +LL+ K+ D++A  K+    +H AC  N  +V  LL +            + P+ I+  K  ++I   L E
Sbjct:  372 TPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLE 622

HSP 2 Score: 103.99 bits (258), Expect = 1.840e-22
Identity = 63/282 (22.34%), Postives = 123/282 (43.62%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHI---------------------------------AAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLL 1005
             PL  A   G  ++   L++ G  I AK +     +H A +  HVD  + L+     ++   V     +H +    + ++ K+L+  + +  AR  N + P+H A  KN +KV+ +L++ G +I A  +  +  +H+                                 AA++   D++R+LL N   ++AR R  +  +H A++ G + I+ LL++    ++A  KD   A+H A      EV  +L +    +D      + P+ ++     +++  LL
Sbjct:  273 TPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLL 554

HSP 3 Score: 100.908 bits (250), Expect = 1.567e-21
Identity = 54/228 (23.68%), Postives = 112/228 (49.12%), Query Frame = 1

Query:  289 GDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDIS 969
            G  ++AK L+D   D  A+       +H ACK+N + +V+ L+    ++ A       P+H +       I+  L+ +D + +        P+H A   N   ++ +L++ G  ++AR +     +HIA++ GNVD++ +LL++   ++A  +    A+H AA+ G+ ++  +LI+    ++A  K     +H       ++V +LL + +  VD +      P+ ++
Sbjct:  348 GHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVA 575

HSP 4 Score: 94.3597 bits (233), Expect = 1.590e-19
Identity = 58/249 (23.29%), Postives = 113/249 (45.38%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIK-QCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLL 1005
             PL  A   G+  +   L+  G  ++A  +    A+H A K    ++   LI +   L+A   K   P+H + K  + ++ ++L+  + +++A+ +N   P+H A H N+ +V  +L++ G +  A  K     +HIAA+   +D+   LLE      A  +     +H ++Q G  +I  LLI+ +  +    K+    +H     + + V ++L K    +D      Y P+ ++       +V  L
Sbjct:  471 TPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFL 719

HSP 5 Score: 93.2041 bits (230), Expect = 3.792e-19
Identity = 54/226 (23.89%), Postives = 116/226 (51.33%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRP-IHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDD 933
             PL  A ++    + + L+ +G +     E     +  A ++ H  +V  L+ S+        K++ P +H + K+++ +   +L+ ND N +   ++ + P+H A+H  +  + ++LI+ G ++    K N+  +H+AAK G  +++ +LLE   NIEA+ R     +H AA+ G  +++++L+++   I A  K+    +H A     ++  ++L   +  VD+
Sbjct:  112 TPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTR-----GKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDE 332

HSP 6 Score: 85.5001 bits (210), Expect = 1.002e-16
Identity = 57/316 (18.04%), Postives = 132/316 (41.77%), Query Frame = 1

Query:  277 ACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIA---------------------------------AKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGE 1122
            A ++G  ++A  LI++G  ++A  +K    +H   K  H+ + + L+  E +++A       P+H +C   N Q+  +L+    +  A  +N   P+H A  KN + + + L++ G    A +K     +H++                                 A+  NV+V  +L +N  NI+   +     +H A+ +G+  ++  L++   +++A        +H         ++ LL + +   + +      P+ I+R    + +++ L+     +  + A +   E++    + P++++E      E
Sbjct:  509 AAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSLKTITKEDETAAAPSQAEEKY--RVVAPEAMHESFMSDSE 822

HSP 7 Score: 84.7297 bits (208), Expect = 1.766e-16
Identity = 65/282 (23.05%), Postives = 118/282 (41.84%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWA----CLN-----------------------------NFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLL 1005
             PL  A   G+  +A  LI  G D+    +     +H A K    ++V  L+    N+EA       P+H + +  + Q++ +L+     I A+ +N   P+H A     V    +L+     ++      + ++H+AA  G+V V ++LL+ N +  AR       +H A +  ++K++ELL++    I A  +     +H A    C+N                             N  ++I++L +   +VD R      P+ I+     V+IV LL
Sbjct:  207 TPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLL 488

HSP 8 Score: 70.0922 bits (170), Expect = 6.085e-12
Identity = 54/278 (19.42%), Postives = 113/278 (40.65%), Query Frame = 1

Query:  268 LINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCN-----------------------------IEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLI-KQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEE 1011
             + A   G+ +     + +  DI   +     A+H A K  H+ +V  L+     +++   K    +H +      +++K+L+ ++ ++  + +N + P++ A  +N   V+ +L+  G N                              + R K  + ++HIAAK  +V    +LL+N+ N +   +     +H A+ YG   I  LLI K  D+    K     +H A       ++ LL +    ++ +      P+  +      ++V++L E
Sbjct:   15 FLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLE 292

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: hppy (gene:FBgn0263395 transcript:FBtr0340456)

HSP 1 Score: 117.857 bits (294), Expect = 5.967e-27
Identity = 87/267 (32.58%), Postives = 133/267 (49.81%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI---SNNQMKYIENNINKYREKLC-HPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSN-SYAISLTGTVYYFAPEIWSEQR---YKYPTDLWAVGITILDMSCRKEIRSKLKPF---------GKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQINRFLR 1845
            +E  + IG G +G+V+K     SN+   IK I    ++ ++ I+  I   R+  C HP II Y+GS      L I ME+   GSL D+ Q+  PL E++     ++ ++GL +LH    +HRDIK  NILL    ++KLADFG+S ++ +  +   S  GT Y+ APE+ + +R   Y    D+WA GIT ++++  +     L P          G     + N    S     F  + L  + K RPTAE+     F+Q    LR
Sbjct:   26 YELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD--CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQCEMSLR 290

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Match: bt (gene:FBgn0005666 transcript:FBtr0334482)

HSP 1 Score: 119.013 bits (297), Expect = 6.074e-27
Identity = 82/271 (30.26%), Postives = 137/271 (50.55%), Query Frame = 1

Query: 1075 KLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQL-GAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNIL--LKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSN---------------LSERMKLFTGSLLYHDSKLRPTAEKAFIQ 1827
            ++  +S+Y++ ++  E IG GAFG V +C   ++   F  K+I  S++  K +         +L H ++I    + +DD  +++ +E+L  G L + I   G  + E + +NY +QI EG+  +H+ +IIH DIKP+NI+   ++S N+KL DFGL+  L+ N      TGT  + APEI + +   + TD+WA G+          + S L PF  D N++    N               +SE  K F   LL  + + R TA +  + 
Sbjct: 7473 EISQQSVYDR-YDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQLHHQKLINLHDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQNIIHLDIKPENIMCQTRSSTNVKLIDFGLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYTDMWATGVL------SYVLLSGLSPFAGD-NDVQTLKNVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKRMTAHECLLH 7735

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 145.976 bits (367), Expect = 2.627e-36
Identity = 88/266 (33.08%), Postives = 150/266 (56.39%), Query Frame = 1

Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQI 1830
            T+ +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S++   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ ++K RP+AE+     F QI
Sbjct:  355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLK-NLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPSHISEHTRDFL-RCIFVEAKYRPSAEELLRHPFSQI 618

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 145.976 bits (367), Expect = 2.689e-36
Identity = 88/266 (33.08%), Postives = 150/266 (56.39%), Query Frame = 1

Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQI 1830
            T+ +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S++   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ ++K RP+AE+     F QI
Sbjct:  343 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLK-NLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPSHISEHTRDFL-RCIFVEAKYRPSAEELLRHPFSQI 606

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 145.976 bits (367), Expect = 3.175e-36
Identity = 88/266 (33.08%), Postives = 150/266 (56.39%), Query Frame = 1

Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQI 1830
            T+ +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S++   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ ++K RP+AE+     F QI
Sbjct:  361 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLK-NLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPSHISEHTRDFL-RCIFVEAKYRPSAEELLRHPFSQI 624

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 140.584 bits (353), Expect = 1.655e-34
Identity = 74/197 (37.56%), Postives = 118/197 (59.90%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            G+L+G+GAFG VF C   ++ +   +K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+ +LH N I+HRDIK  NIL  ++ N+KL DFG SR L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M
Sbjct:  365 GKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLK-NLFHERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEM 560

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 140.584 bits (353), Expect = 1.867e-34
Identity = 74/197 (37.56%), Postives = 118/197 (59.90%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            G+L+G+GAFG VF C   ++ +   +K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+ +LH N I+HRDIK  NIL  ++ N+KL DFG SR L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M
Sbjct:  357 GKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLK-NLFHERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEM 552

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 144.436 bits (363), Expect = 1.118e-35
Identity = 86/256 (33.59%), Postives = 146/256 (57.03%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I +  + L H RI+QY+GS++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N     N SE+ + F   +L  +++ RPTAE+
Sbjct:  347 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEI-QLLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPPNTSEQCRDFVKRILV-EARQRPTAEE 600

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 144.821 bits (364), Expect = 1.122e-35
Identity = 86/256 (33.59%), Postives = 145/256 (56.64%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+GS++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N     N SE+ + F   +L  +++ RPTAE+
Sbjct:  365 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLK-NLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPPNTSEQCRDFVKRILV-EARQRPTAEE 618

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 142.895 bits (359), Expect = 3.970e-35
Identity = 84/253 (33.20%), Postives = 144/253 (56.92%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            G+L+G+GAFG V+ C   ++ +   +K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+ +LH N I+HRDIK  NIL  +S N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W+VG T+++M   K   ++ +      K   +  N    +++SE  + F    ++ ++K+RP++E+
Sbjct:  342 GKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKEVNALECEIQLLK-NLLHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPAHVSEHCRDFL-KRIFVEAKVRPSSEE 592

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 142.895 bits (359), Expect = 5.291e-35
Identity = 84/257 (32.68%), Postives = 144/257 (56.03%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYRE------------KLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            G+L+G+GAFG V+ C   ++ +   +K     Q+++  +++   +E             L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+ +LH N I+HRDIK  NIL  +S N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W+VG T+++M   K   ++ +      K   +  N    +++SE  + F    ++ ++K+RP++E+
Sbjct:  370 GKLLGQGAFGRVYLCYDADTGRELAVK-----QVQFDPDSLETSKEVNALECEIQLLKNLLHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPAHVSEHCRDFL-KRIFVEAKVRPSSEE 620

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 132.494 bits (332), Expect = 1.102e-31
Identity = 71/196 (36.22%), Postives = 117/196 (59.69%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYIS---NNQMKYIENNINKYREKLC----HPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            G+L+G+GAFGEV+ C   +  +   +K +    ++Q    E N  +   +L     H RI+QY+G ++D  +  L IF+EY+  GS+ D ++    L E  T  Y++QI++G+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ +     S +   S+TGT Y+ +PE+ S + Y    D+W+V  T+++M
Sbjct:  357 GKLLGRGAFGEVYLCYDVDKGRELAVKQVPFDPDSQETSKEVNALECEIQLLKLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVISGEGYGRKADVWSVACTVVEM 552

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873])

HSP 1 Score: 141.354 bits (355), Expect = 9.454e-35
Identity = 84/251 (33.47%), Postives = 136/251 (54.18%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYIS-NNQMKYIENNINKYR------EKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSN--LSERMKLFTGSLL---YHDSKLRPTAEK 1815
            G+L+G+GAFG V+ C   ++ +   +K +  N +       +N         + L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+ +LH N I+HRDIK  NIL  ++ NIKL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W+V  T+++M   K   ++ +            +N  L   +  +T   L   + ++KLRP+AE+
Sbjct:  359 GKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEE 609

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874])

HSP 1 Score: 138.658 bits (348), Expect = 7.810e-34
Identity = 83/256 (32.42%), Postives = 144/256 (56.25%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMN--LLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D     L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ +++ RP+AE+
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK-NLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL-RRIFVEARQRPSAEE 615

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Stk24 (serine/threonine kinase 24 [Source:MGI Symbol;Acc:MGI:2385007])

HSP 1 Score: 130.183 bits (326), Expect = 6.733e-32
Identity = 84/248 (33.87%), Postives = 128/248 (51.61%), Query Frame = 1

Query: 1099 EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCH---PRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAI-SLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG-----KDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            E+ F K E IGKG+FGEVFK     + K   IK I   + +    +I +    L     P + +Y+GS   D  L I MEYL  GS  DL++ G PL E++     ++I++GL +LH    IHRDIK  N+LL     +KLADFG++ +L        +  GT ++ APE+  +  Y    D+W++GIT ++++  +   S+L P          N      N S+ +K F  + L  +   RPTA++
Sbjct:   21 EELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPG-PLDEIQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKE 267

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:MGI Symbol;Acc:MGI:1203481])

HSP 1 Score: 129.798 bits (325), Expect = 2.661e-31
Identity = 69/203 (33.99%), Postives = 117/203 (57.64%), Query Frame = 1

Query: 1114 KGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYI--ENNINKYREK------LCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSREL-------NSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRK 1677
            KGE++G+GA+G V+ C LT+  +   +K ++ +    +  E    K +E+      L H  I+ Y G+  ++  L IFME++  GS+S +I    PL E+    Y++QI++G+A+LH N ++HRDIK  N++L  +  IKL DFG ++ L         +    S+ GT Y+ APE+ +E  Y   +D+W++G T+ +M+  K
Sbjct:  250 KGEILGRGAYGTVY-CGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGK 451

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Match: Map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:MGI Symbol;Acc:MGI:1203481])

HSP 1 Score: 129.028 bits (323), Expect = 4.207e-30
Identity = 69/203 (33.99%), Postives = 116/203 (57.14%), Query Frame = 1

Query: 1114 KGELIGKGAFGEVFKCNLTNSNKAFVIKYIS--NNQMKYIENNINKYREK------LCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSREL-------NSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRK 1677
            KGE++G+GA+G V+ C LT+  +   +K ++   +     E    K +E+      L H  I+ Y G+  ++  L IFME++  GS+S +I    PL E+    Y++QI++G+A+LH N ++HRDIK  N++L  +  IKL DFG ++ L         +    S+ GT Y+ APE+ +E  Y   +D+W++G T+ +M+  K
Sbjct: 1250 KGEILGRGAYGTVY-CGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAYLHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGK 1451

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|F4HRJ4|M3K3A_ARATH (Mitogen-activated protein kinase kinase kinase 3 OS=Arabidopsis thaliana OX=3702 GN=MAPKKK3 PE=1 SV=1)

HSP 1 Score: 144.821 bits (364), Expect = 4.838e-35
Identity = 88/254 (34.65%), Postives = 141/254 (55.51%), Query Frame = 1

Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIK---YISNNQ-----MKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPE-IWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG--------KDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            T++KG+ +G G FG+V+    +   K   IK    IS++Q     +K +   IN   + LCHP I+QY+GS   +  L +++EY+  GS+  L++      E    NY++QI+ GLA+LH  + +HRDIK  NIL+  +  IKLADFG+++ + + S  +S  G+ Y+ APE + S+  Y +  D+W++G TIL+M+  K   S+ +           KD  EI +  +LS   K F    L  +  +RPTA +
Sbjct:  213 TWKKGKFLGSGTFGQVYLGFNSEKGKMCAIKEVKVISDDQTSKECLKQLNQEINLLNQ-LCHPNIVQYYGSELSEETLSVYLEYVSGGSIHKLLKDYGSFTEPVIQNYTRQILAGLAYLHGRNTVHRDIKGANILVDPNGEIKLADFGMAKHVTAFSTMLSFKGSPYWMAPEVVMSQNGYTHAVDIWSLGCTILEMATSKPPWSQFEGVAAIFKIGNSKDTPEIPD--HLSNDAKNFIRLCLQRNPTVRPTASQ 463

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q99759|M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2)

HSP 1 Score: 139.813 bits (351), Expect = 2.806e-33
Identity = 83/256 (32.42%), Postives = 146/256 (57.03%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I +  + L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ +++ RP+AE+
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEI-QLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL-RRIFVEARQRPSAEE 615

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q61084|M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus OX=10090 GN=Map3k3 PE=1 SV=1)

HSP 1 Score: 138.658 bits (348), Expect = 5.463e-33
Identity = 83/256 (32.42%), Postives = 144/256 (56.25%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMN--LLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG---KDVNEIIN---SSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D     L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K   ++ +      K   +  N    S++SE  + F    ++ +++ RP+AE+
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK-NLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL-RRIFVEARQRPSAEE 615

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q9Y2U5|M3K2_HUMAN (Mitogen-activated protein kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP3K2 PE=1 SV=2)

HSP 1 Score: 138.658 bits (348), Expect = 6.399e-33
Identity = 82/252 (32.54%), Postives = 139/252 (55.16%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSN--LSERMKLFTGSLL---YHDSKLRPTAEK 1815
            G+L+G+GAFG V+ C   ++ +   +K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+ +LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W+V  T+++M   K   ++ +            +N  L   +  +T   L   + ++KLRP+A++
Sbjct:  359 GKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLK-NLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADE 609

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Match: sp|Q61083|M3K2_MOUSE (Mitogen-activated protein kinase kinase kinase 2 OS=Mus musculus OX=10090 GN=Map3k2 PE=1 SV=2)

HSP 1 Score: 136.346 bits (342), Expect = 3.071e-32
Identity = 83/251 (33.07%), Postives = 134/251 (53.39%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYIS-NNQMKYIENNINKYR------EKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSN--LSERMKLFTGSLL---YHDSKLRPTAEK 1815
            G+L+G+GAFG V+ C   ++ +   +K +  N +       +N         + L H RI+QY+G ++D  +  L IFME    GS+ D ++    L E  T  Y++QI+EG+ +LH N I+HRDIK  NIL  ++ NIKL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W+V  T+++M   K   ++ +            +N  L   +  +T   L   + ++KLRP+AE+
Sbjct:  359 GKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMELSPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEE 609

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A0H3YJG2 (Slc42a-1 OS=Schmidtea mediterranea OX=79327 GN=slc42a-1 PE=2 SV=1)

HSP 1 Score: 196.823 bits (499), Expect = 3.925e-49
Identity = 129/417 (30.94%), Postives = 199/417 (47.72%), Query Frame = 1

Query:  457 KRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYL--------EQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLT----GTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            + PI Y+CK  + +I+K  I   CN+++ D    R +HYA   N+  ++ +LI++G  I   +   M  IH+A K  N++  ++L+ENN                                CD+   DK KR  +  A   +F  +IKL+ +CQ                                  I  I+    LKC + C+HK C  S   K  +  + I  G++G VF  N + +++ F +K I   N + +YIE NIN ++  LCH RI+++FG+     N  IFMEYL        ++ S  DL+             ++KQI+E L+FLH+  IIHRDIKP+N+LL    N+KL+DFGLS  L+S +  I       GT  Y APEI + + Y    D+W++G T++ +
Sbjct:  540 RSPILYACKYGHRKIVKYFIKQKCNVDSFDCEFRRALHYAVISNNNDIVKLLIESGAAINVPDSLLMMPIHLACKVNNIEAAQLLMENN--------------------------------CDMVTLDKLKRSPLQIAETGDFENMIKLIKECQ---------------------------------IIREIAAEMQLKCGKLCNHKFCYTSFQRKKIKNRKCIASGSYGTVFLYNESGTDRKFAVKKIPKQNIRARYIEANINDFKNLLCHERIVKHFGAFHKKENHYIFMEYLDTLQKKKYQKKSPGDLLL------------FAKQILEALSFLHERSIIHRDIKPENVLLDIDGNLKLSDFGLSLLLSSVAEDIQKEGRCCGTYCYAAPEILNAELYTCSVDIWSLGATMIQL 879

HSP 2 Score: 71.633 bits (174), Expect = 4.925e-9
Identity = 36/104 (34.62%), Postives = 60/104 (57.69%), Query Frame = 1

Query:  265 PLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYA 576
            P++ AC+ G  K+ K+ I   C++++ D + RRA+H+A   N+ DIVK LI S   +   D  L  PIH +CK  N +  ++L+ N+C++   D+    P+  A
Sbjct:  542 PILYACKYGHRKIVKYFIKQKCNVDSFDCEFRRALHYAVISNNNDIVKLLIESGAAINVPDSLLMMPIHLACKVNNIEAAQLLMENNCDMVTLDKLKRSPLQIA 645

HSP 3 Score: 65.855 bits (159), Expect = 2.930e-7
Identity = 33/120 (27.50%), Postives = 63/120 (52.50%), Query Frame = 1

Query:  358 RRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLE 717
            R  I +ACK  H  IVK+ I  +CN+++ D + +R +HY+    N  I+K+LI +   I   D     P+H A   N+++   +L++  C++   +K     + IA      ++++++ E
Sbjct:  540 RSPILYACKYGHRKIVKYFIKQKCNVDSFDCEFRRALHYAVISNNNDIVKLLIESGAAINVPDSLLMMPIHLACKVNNIEAAQLLMENNCDMVTLDKLKRSPLQIAETGDFENMIKLIKE 659

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A1F8VAI3 (Uncharacterized protein OS=Coxiella sp. RIFCSPHIGHO2_12_FULL_44_14 OX=1797697 GN=A3F41_02950 PE=4 SV=1)

HSP 1 Score: 170.244 bits (430), Expect = 3.647e-40
Identity = 141/568 (24.82%), Postives = 265/568 (46.65%), Query Frame = 1

Query:  295 FKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGC--NIEARN----------KWNMRS------------------------IHIAAKSGNVDVLRVLLENNCNIEARDRWNK-RAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLY-EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYR--EKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAIS--LTGTVYYFAPEIWSEQR-YKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEII--------NSSNLSERMKLFTGSLL----YHDSKLRPTAEKAFIQI 1830
             K+ + L+++G  I  +D+K R  +H A +R HVDIVKFL++ + + +  D + +  +H + K  N  I ++L+    N    D+     +H+AT  +   ++ +LI  G   NI A+N          +W   +                        +  AA  G+V+++++LLE+N N+E ++  N    +H+A  YG   +++LL+    ++E+ + +    +H A      +++ LL       +  +     P++++   + V+++   +  +    + +   L   +  D  L     Y E TF+K  ++GKG FG V      +++ A    +++N     +E   ++     +L  P+I+Q +G I    +  I ME+L +GSL  ++    PL        +  I  GLAFLHK +I+HRD+K  N+LL +    KL DFGL++  N +S      + GT+ + APE++  +  Y    D+++ GIT+ ++  RK       PF    N+ +           ++ E        L+      +S  RPTA++A +Q+
Sbjct:  412 MKVVQLLVNAGATIGTRDKKGRTPLHLATERKHVDIVKFLLDRKADPQTVDEENQTALHLAVKASNRAITQLLLEAGANPNISDKEGKTALHFATDPH---IVELLISKGADPNISAKNGDTPLKGAYHQWQTSNSSEFREIVKLLLMAKANPLAHFDLLPYAAMLGDVEIVKLLLESNINLEIKNNENNLTPLHFATIYGHAPVVQLLLNAGANLESRNNEDETPLHCAATKGHAKIVGLLLDKGANTETVNKAGKTPLNLASHTEVVKLLRATKSTVGTPMVVQKNVLSAADKTDLLLSFTLDYTELTFDK--VLGKGGFGVVHLGVYRHNDVAIKQLHVTNPSQAALEEFQSEMAIMARLRCPQIVQLYG-IYLQPSYGIVMEFLARGSLYKVLHNSEPLSWETRHQIAFDIACGLAFLHKENILHRDLKSLNVLLNDQMRAKLTDFGLAKIKNESSSVTGSQVVGTLQWMAPELFKRKAVYAKEADIYSFGITLWELVARK------TPFEDAQNQALIKQWVLEGEREDIPEECPPKLARLIKFCWMQESTARPTADEAVMQL 967

HSP 2 Score: 74.3294 bits (181), Expect = 7.812e-10
Identity = 61/274 (22.26%), Postives = 121/274 (44.16%), Query Frame = 1

Query:  229 ICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHW------ACKRNHV---DIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNS-----------------------------------------VKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ-CDIEACDKDKRKAIHWACLNNFLEVI 897
            I +   + KIS+ +  A  +GD  LA  +  S  DI A  +   RA+++      +    HV   +  KFL+ +   ++  +     P+HY+ +Q   ++ KI + +  +++A+D+N    +HYA    S                                         +KV+ +L+ AG  I  R+K     +H+A +  +VD+++ LL+   + +  D  N+ A+H A +     I +LL++   +    DK+ + A+H+A   + +E++
Sbjct:  243 ITASQAITKISINVHEADAQGD-TLAHHIAASD-DINALQQLTARAVNFNVFNKLSYSPLHVAAPEAAKFLLKNGMLVDCANATRMTPLHYAAQQGKLELAKIFLAHGADLKAKDQNGRTVLHYADMSKSTNEIALVSLFLEAKVDPNVADKDGRAALHQVVAVEHYDDQLMKVVQLLVNAGATIGTRDKKGRTPLHLATERKHVDIVKFLLDRKADPQTVDEENQTALHLAVKASNRAITQLLLEAGANPNISDKEGKTALHFATDPHIVELL 514

HSP 3 Score: 71.633 bits (174), Expect = 5.465e-9
Identity = 51/179 (28.49%), Postives = 94/179 (52.51%), Query Frame = 1

Query:  292 DFKLAKFLIDSGCD--IEAK--DEKKRRAIH-WACKRNH--VDIVKFLINSECN-LEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARD-ENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKIL 801
            D  + + LI  G D  I AK  D   + A H W    +    +IVK L+ ++ N L   D+     + Y+    + +I+K+L+ ++ N+E ++ EN+  P+H+AT      V+ +L+ AG N+E+RN  +   +H AA  G+  ++ +LL+   N E  ++  K  ++ A+    +K+L
Sbjct:  507 DPHIVELLISKGADPNISAKNGDTPLKGAYHQWQTSNSSEFREIVKLLLMAKANPLAHFDL-----LPYAAMLGDVEIVKLLLESNINLEIKNNENNLTPLHFATIYGHAPVVQLLLNAGANLESRNNEDETPLHCAATKGHAKIVGLLLDKGANTETVNKAGKTPLNLASHTEVVKLL 680

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: T1EDA5 (Protein kinase domain-containing protein OS=Helobdella robusta OX=6412 GN=20194557 PE=4 SV=1)

HSP 1 Score: 156.377 bits (394), Expect = 3.594e-39
Identity = 78/199 (39.20%), Postives = 121/199 (60.80%), Query Frame = 1

Query: 1102 KTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI----SNNQ-----MKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN--SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            K++++G L+G G+FG+VF C    + K + +K +     N+Q     +  +   IN  +E + HP I+QYFG   D +   I MEY+  GS+ D I+   PL E  T++Y+KQ++ GL +LHK  I+HRD+K  NIL  N  N+KL+DFG S+ L   SNS   + TGT+YY +PE+     Y   TD+W++G ++++M
Sbjct:    2 KSWKRGRLLGSGSFGQVFLCCDMETGKEYAMKQVHIFSKNSQHCSRVLSALREEINILKEGVKHPHIVQYFGCQDDGVVFSILMEYMPGGSVKDQIKQYGPLTERNTISYTKQVLLGLEYLHKKSIVHRDVKGANILRDNEGNVKLSDFGASKRLQTISNSIMQTQTGTIYYMSPELLDGNGYGRKTDIWSLGCSVVEM 200

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A7S4G7 (Predicted protein (Fragment) OS=Nematostella vectensis OX=45351 GN=v1g104385 PE=4 SV=1)

HSP 1 Score: 152.14 bits (383), Expect = 1.034e-37
Identity = 91/253 (35.97%), Postives = 142/253 (56.13%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN---SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPF------GKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + KG+L+G GAFG+V+ C+  ++ +   +K I        + N++K +E  I ++ +   + RI+QY+G   DD+++ IFMEYL  GS+ + I+    L E  T  YS+QI+EG+ +LH N I+HRDIK  NIL     N+KLADFG S+ L    S +   S+ GT Y+ APE+ + + Y    D+W+VG T+++M   K   +  +P            E    S+LS     F  S L  +SK RP+A++
Sbjct:    4 WRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEI-EFMKAFRNERIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRSKTGFRSVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIATQPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADE 255

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Match: A0A1I8I3V2 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011660g3 PE=4 SV=1)

HSP 1 Score: 156.377 bits (394), Expect = 6.122e-37
Identity = 76/196 (38.78%), Postives = 124/196 (63.27%), Query Frame = 1

Query: 1111 EKGELIGKGAFGEVFKCNLTNSNKAFVIKYI---------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLT--GTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            ++G+L+G+GAFG+V+KC+  +S + F +K +         ++ ++K +E  I   + K  H RI+QY G  QD   L IFMEY++ GSL D I+   P+ E+    Y++ ++EGL+FLH+N I+HRDIK  NIL  +  N+KL+DFG ++ + +   A+S T  GT  Y APE+   ++Y Y  D+W++G T+++ 
Sbjct:  269 KQGDLLGQGAFGKVYKCHDQDSGRLFAMKVVQLDANQDPATSREVKALEIEIQTLK-KFSHERIVQYLGYHQDAYRLCIFMEYMDCGSLRDEIKRFGPIREILARKYTRMVLEGLSFLHRNTIVHRDIKGANILKDSQGNVKLSDFGSAKHIKTLQSAMSTTFAGTAPYIAPEVIRGKKYHYKADIWSLGSTVVEF 463

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 145.206 bits (365), Expect = 4.448e-36
Identity = 88/266 (33.08%), Postives = 147/266 (55.26%), Query Frame = 1

Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRK------EIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQI 1830
            T+ +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S++   S+TGT Y+ +PE+ S   Y    D+W++G T+++M   K      E  + +          I  S+ SE+ + F    ++ ++K RP+AE+     F QI
Sbjct:  355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLK-NLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILPSHTSEQTRDFI-RRIFVEAKHRPSAEELLRHPFSQI 618

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Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRK------EIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQI 1830
            T+ +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S++   S+TGT Y+ +PE+ S   Y    D+W++G T+++M   K      E  + +          I  S+ SE+ + F    ++ ++K RP+AE+     F QI
Sbjct:  355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLK-NLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILPSHTSEQTRDFI-RRIFVEAKHRPSAEELLRHPFSQI 618

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Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRK------EIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQI 1830
            T+ +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S++   S+TGT Y+ +PE+ S   Y    D+W++G T+++M   K      E  + +          I  S+ SE+ + F    ++ ++K RP+AE+     F QI
Sbjct:  355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLK-NLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILPSHTSEQTRDFI-RRIFVEAKHRPSAEELLRHPFSQI 618

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:103026704])

HSP 1 Score: 141.354 bits (355), Expect = 7.622e-35
Identity = 75/197 (38.07%), Postives = 118/197 (59.90%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            G+L+G+GAFG VF C   ++ +   +K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+ +LH N I+HRDIK  NIL  ++ N+KL DFG SR L     S +   S+TGT Y+ +PE+ S + Y    D+W+VG T+++M
Sbjct:  362 GKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLK-NLFHERIVQYYGCLRDTHERTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEM 557

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Match: map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:ZFIN;Acc:ZDB-GENE-081104-140])

HSP 1 Score: 132.88 bits (333), Expect = 2.823e-34
Identity = 68/207 (32.85%), Postives = 121/207 (58.45%), Query Frame = 1

Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI---------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAI-------SLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRK 1677
            T+ KGE++G+GA+G V+ C LT+  +   +K +         +  +   +E  ++  +  L HP I+ + G+   D  + IFMEY+  GS+S ++    PL E     Y++Q++EG+A+LH+N +IHRD+K  N++L  +  +KL DFG +R LN  +++        S+ GT Y+ APE+ +E  +   +D+W++G T+ +M+  K
Sbjct:   15 TWAKGEVLGRGAYGTVY-CGLTSQGQLIAVKQVLLDVSTSETAEKEYSRLEREVDLLK-NLEHPNIVGFLGTALTDNVISIFMEYVPGGSISSVLNRFGPLPEKVFALYTRQVLEGVAYLHENRVIHRDLKGNNLMLMPTGVVKLIDFGCARRLNRLTHSGGNSDLLKSVHGTPYWMAPEVINETGHGKKSDVWSIGCTVFEMATGK 219

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 144.436 bits (363), Expect = 1.797e-36
Identity = 85/256 (33.20%), Postives = 142/256 (55.47%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDM--NLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN---SNSYAI-SLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGS-------LLYHDSKLRPTAE 1812
            +++G+L+G+GAFG V+ C   ++ +   +K +        ++ ++  +E  I   +  L H RI+QYFG ++D     L IFMEY+  GS+ D ++    L E  T  Y++QI+EG++FLH N I+HRDIK  NIL  ++ N+KL DFG S+ L    S   A+ S+TGT Y+ +PE+ + + Y    D+W+VG T+++M   K   ++ +         I +     R+ L            ++ ++KLRP+AE
Sbjct:  359 WQRGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPGSVETSKEVNALECEIQLLK-NLQHERIVQYFGCLRDPQQKTLSIFMEYMPGGSIKDQLRAYGALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGTAMRSVTGTPYWMSPEVINGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFK--IATQPTDPRLPLHASEHARDLLRRIFVEAKLRPSAE 611

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92])

HSP 1 Score: 130.568 bits (327), Expect = 8.372e-33
Identity = 92/272 (33.82%), Postives = 135/272 (49.63%), Query Frame = 1

Query: 1066 CDHKLCPK---SLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCH---PRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIK--PQNILLKNSENIKLADFGLSRELNSNSYAI-SLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG-----KDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQ 1827
            C H   P+   +  E+ F K E IGKG+FGEVFK     + +   IK I   + +    +I +    L     P +  YFGS      L I MEYL  GS  DLI+ G PL E +     ++I++GL +LH    IHRDIK    N+LL    ++KLADFG++ +L        +  GT ++ APE+  +  Y +  D+W++GIT ++++  +   S+L P          N      N S+  K F  S L  D + RPTA++     FIQ
Sbjct:    9 CPHPRPPQNSCADPEELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALDLIKPG-PLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPTLEGNYSKAFKEFVDSCLNKDPQFRPTAKELLKHKFIQ 279

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865])

HSP 1 Score: 122.094 bits (305), Expect = 6.141e-29
Identity = 81/256 (31.64%), Postives = 127/256 (49.61%), Query Frame = 1

Query: 1099 EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI---SNNQMKYIENNINKYREKLC-HPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSN-SYAISLTGTVYYFAPEIWSEQR---YKYPTDLWAVGITILDMSCRKEIRSKLKPF---------GKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            ++ FE  E +G G +G+V K     + +   IK I     +    I+  I   +E  C H  I+ Y+GS      L I ME+   GSL D+  +  PL E +    +++ ++GLA+LH    +HRDIK  NILL +  ++KLADFG+S ++ +  +   S  GT Y+ APE+ + +R   Y +  D+WAVGIT ++++  +     L P          G    ++ +    S     F    L  + K RPTAEK
Sbjct:   11 QEDFELAERLGSGTYGDVHKARNVQTGELVAIKIIKLEPGDDFSVIQQEIVMMKE--CKHTNIVAYYGSYLRHDKLWICMEHCGGGSLQDIYHVTGPLTERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEK 264

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:ZFIN;Acc:ZDB-GENE-081104-140])

HSP 1 Score: 112.849 bits (281), Expect = 5.625e-28
Identity = 63/220 (28.64%), Postives = 115/220 (52.27%), Query Frame = 1

Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREK------LCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSREL------NSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPF 1704
            T+ KG  +GKGAFG VF   LTN  K   +K +        + NQ    ++ + K +++      L HP +++Y G+  +     IFME++  G++++ ++   PL E    +Y  Q+  GLA+LH + ++H D+K  N ++  +  +KL DFG ++ +      + N    S+ GT Y+ APE+ +   Y    D+W++G T+ +M+  +   + + P 
Sbjct:   14 TWIKGNRLGKGAFGTVF-LGLTNQGKLIAVKELELRDAQSANGNQGGQKQSELQKLQDEVELLTTLHHPNVVEYLGTEMEGNRFSIFMEFVPGGTVAETVRGFGPLGESVCRSYIAQMTRGLAYLHGHGVMHGDVKGSNAVITPAGVVKLIDFGCAQRVALALSCHENGGLHSVHGTAYWMAPEVINGTGYARRADVWSLGCTLHEMAVGRPPFADMAPM 232

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006402.1 (pep scaffold:Pmarinus_7.0:GL481397:10373:21355:-1 gene:ENSPMAG00000005783.1 transcript:ENSPMAT00000006402.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 112.849 bits (281), Expect = 8.351e-28
Identity = 64/211 (30.33%), Postives = 109/211 (51.66%), Query Frame = 1

Query: 1114 KGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYRE-------------KLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFL----HKNHIIHRDIKPQNILLKN-SENIKLADFGLSRELNS-----NSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRK 1677
            +G+ IG GAF   F+     +     +K     Q+ Y+ N  ++  E             +L HP II+  G+  +  N  +F+E++  GS+++L+    P  E   ++Y +Q++ GLA+L    H N +IHRDIK  N+L+ +  + +++ADFG +  L S       +   L GT+ + APE+    +Y    D+W+VG  I++MSC K
Sbjct:   26 RGQQIGLGAFSSCFQAQDIGTGTLMAVK-----QVTYVRNTASEQDEVVQTLREEIRMMSRLDHPNIIRMLGATCEKSNYNLFIEWMAGGSVANLLNKYGPFHERVVISYVEQLLRGLAYLHSNQHSNQLIHRDIKGANLLVDSMGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGLQYGRSCDIWSVGCVIIEMSCAK 231

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757])

HSP 1 Score: 123.25 bits (308), Expect = 4.129e-30
Identity = 75/210 (35.71%), Postives = 118/210 (56.19%), Query Frame = 1

Query: 1123 LIGKGAFGEVFKCNLTNSNKAFVIKYIS--NNQMKYIENNIN--KYREKLCHPRIIQYFGSIQDDMNLLIF--MEYLEQGSLS----DLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMS-----CRKE-IRSKLKPF 1704
            ++G+GA G V KC L N +K F +K I+  N   +Y +      ++        I++Y+G   DD N  I+  MEY+   SL     +L++ G  + E      ++ ++ GL++LH+  +IHRDIKPQNILL  +  +KL DFG+S E   NS A + TGT +Y APE    Q Y   +D+W++G+TIL+++     C  E + + + PF
Sbjct:  226 ILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEA-VNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPF 434

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061])

HSP 1 Score: 120.939 bits (302), Expect = 1.900e-29
Identity = 70/192 (36.46%), Postives = 110/192 (57.29%), Query Frame = 1

Query: 1123 LIGKGAFGEVFKCNLTNSNKAFVIKYIS--NNQMKYIENNIN--KYREKLCHPRIIQYFGSIQDDMNLLIF--MEYLEQGSLS----DLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMS 1668
            ++G+GA G V KC L N  K F +K I+  N   +Y +      ++ +      I+QY+G   D+ +  I+  MEY+   SL     +L++ G  + E      ++ ++ GL++LH+  +IHRDIKPQNILL     IKL DFG+S E   NS A++ TGT +Y APE    Q Y    D+W++G+T+L+++
Sbjct:  219 ILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEA-VNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVA 409

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124])

HSP 1 Score: 110.538 bits (275), Expect = 1.386e-26
Identity = 62/191 (32.46%), Postives = 110/191 (57.59%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQ---MKYIENNINKYRE-KLC-HPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            F+    +G G+FG V      ++ + + IK +   Q   MK +E+  ++ R  KL  HP +I+ +G+ QD  N+ + M+Y+E G L  L++            Y+ ++I  L +LH ++II+RD+KP+NILL  + +IK+ DFG ++E+ + ++  +L GT  Y APE+ + + Y    D W++G+ I +M
Sbjct:   70 FQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTW--TLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEM 258

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 111.694 bits (278), Expect = 8.470e-26
Identity = 76/240 (31.67%), Postives = 127/240 (52.92%), Query Frame = 1

Query: 1120 ELIGKGAFGEVFKCNLTNSNKAFVIK---YISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAP-LMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKP----FGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            ++IG+G++G V+K    ++++   IK   Y ++ ++  I   I+  +  L H  I++Y G I+    L I +EY   GSL  LI   +  L E ++  Y  Q + GL +LH   +IHRDIK  NILL     +KLADFG+S  +NS+  A++L GT+ + APEI   +     +D+W++G T+++M  +      L      +  + +     S+ SE +K F       +   RPTA++
Sbjct:   29 QVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKN-LNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSS--ALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQ 265

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631])

HSP 1 Score: 108.997 bits (271), Expect = 8.959e-25
Identity = 71/210 (33.81%), Postives = 121/210 (57.62%), Query Frame = 1

Query: 1114 KGELIGKGAFGEVFKC-NLTNSN-----KAFVIKYISNNQ-----MKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSR---ELNSNSYAISLTGTVYYFAPE-IWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLK 1698
            KGE+IGKG+FG V+ C N+T        +  V KY S N+     ++ + + ++  ++ L H  I+QY G    +    +F+EY+  GS+  LI++     E    + + Q+++GLA+LH   I+HRD+K  N+LL      K++DFG+SR   ++ SNS  +++ GTV++ APE + ++Q Y    D+W++G  +L+M   K   S L+
Sbjct: 1177 KGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKD-LDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNS-DMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLE 1384

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7])

HSP 1 Score: 152.14 bits (383), Expect = 1.361e-41
Identity = 91/253 (35.97%), Postives = 142/253 (56.13%), Query Frame = 1

Query: 1108 FEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN---SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPF------GKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            + KG+L+G GAFG+V+ C+  ++ +   +K I        + N++K +E  I ++ +   + RI+QY+G   DD+++ IFMEYL  GS+ + I+    L E  T  YS+QI+EG+ +LH N I+HRDIK  NIL     N+KLADFG S+ L    S +   S+ GT Y+ APE+ + + Y    D+W+VG T+++M   K   +  +P            E    S+LS     F  S L  +SK RP+A++
Sbjct:    4 WRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEI-EFMKAFRNERIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRSKTGFRSVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIATQPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADE 255

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO47821 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL88])

HSP 1 Score: 126.331 bits (316), Expect = 2.002e-32
Identity = 80/263 (30.42%), Postives = 138/263 (52.47%), Query Frame = 1

Query: 1099 EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYIS--NNQMKYIENNINKYREK------LCHPRIIQYFGSIQDDM--NLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSREL-------NSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSS-------NLSERMKLFTGSLLYHDSKLRPTAEK 1815
            E  ++KG ++GKGAFG VF   L N+ +   +K +    N +   E    K +E+      L H  I+QY G+  DD    + IFME++  GS++  ++     +E     Y++QI++G+++LH N++IHRDIK  NI+L  +  IKL DFG ++++       + ++   S+ GT Y+ APE+  E  +   +D+W++G T+ +M+  +   S + P    +  I N S       + S     F  S +  D   RP+A++
Sbjct:    2 EIEWQKGNVLGKGAFGTVF-LGLVNTGELIAVKQVELHPNNVDAAERQYEKLQEEVGLLKSLKHKNIVQYIGTCMDDSQCTINIFMEFVPGGSIAQALKRFGAFVEPVFRRYTRQILDGVSYLHNNNVIHRDIKGGNIMLMPNGVIKLIDFGCAKKICMVGAHVSKSNILRSMRGTPYWMAPEVIRETGHGRKSDIWSIGCTVFEMATGQPPWSNVPPLSA-IFAIGNGSPVPRLDESFSAAAIDFVTSCMTRDQDTRPSADE 262

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO49690 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG02])

HSP 1 Score: 126.331 bits (316), Expect = 2.431e-32
Identity = 73/191 (38.22%), Postives = 107/191 (56.02%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLC----HPRIIQYFGSIQDDMNLL-IFMEYLEQGSLSDLI--QLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNS-YAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            G+ IGKG++GEVF        K +V+K +   +    E    +   KL     HP I+ Y  S QDD   L I M + E G L   +  Q G PL E + V +  QI   L ++H+ HI+HRD+K QNI L  S+ IK+ D G++R L S+S  A +L GT YY +PE++S + Y + +D+WA+G  + +M
Sbjct:    9 GKCIGKGSYGEVFLSKHKKDKKQYVLKKVDLQKASVRERKAAELEAKLLSQLRHPNIVSYRESFQDDTGFLYIAMNFCEGGDLYSRLKAQKGIPLDENQIVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKSKIIKVGDLGIARVLESSSDMATTLIGTPYYMSPELFSNKPYNHKSDVWALGCCLYEM 199

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO33652 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRL3])

HSP 1 Score: 118.242 bits (295), Expect = 6.384e-28
Identity = 62/196 (31.63%), Postives = 107/196 (54.59%), Query Frame = 1

Query: 1102 KTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI-------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAI-SLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            + + +G L+GKG F  V++    ++NK + +K +       S  + + IE  I  +R  L H  ++ + GS QD+MN  I +E   + SL  +++    L E +   + +Q IE  ++LH+  +IHRDIK  N  + ++  ++L DFGL+  L  + Y I ++ GT  Y APE+ S++ + Y  D WA+G  +  M
Sbjct:   15 RRYFRGRLLGKGGFARVYEVTDMSTNKIYALKVVPKKRLSKSTKEYRKIEMEIELHR-TLRHHYVVGFHGSFQDEMNFYILLELCSRKSLVQMLKTRGKLTEPEVRFFMQQAIEACSYLHEQRVIHRDIKVGNFFINSNMELRLGDFGLAVRLKPDEYKIRTMCGTPNYIAPEVLSKEGHSYEVDTWALGCVMYTM 209

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4])

HSP 1 Score: 114.005 bits (284), Expect = 3.408e-27
Identity = 79/248 (31.85%), Postives = 124/248 (50.00%), Query Frame = 1

Query: 1099 EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCH---PRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSN-SYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG-----KDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            EK F K E IGKG+FGEVFK     +N+   IK I   + +    +I +    L       + +Y GS      L I MEYL  GS  DL++ G  + E       +++++GL +LH    +HRDIK  N+L+  + ++KLADFG++ +L    +   +  GT ++ APE+  +  Y    D+W++GIT ++++  +   S L P          N    + N S+  K F    L  D   RPTA++
Sbjct:    8 EKLFSKLERIGKGSFGEVFKGIDNRTNEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSLYVTKYHGSYLKGTKLWIIMEYLGGGSALDLMKAGN-IEEFYIATILREVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQLTDTLNKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPELTGNFSKAFKEFVSLCLNKDPNDRPTAKE 254

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297])

HSP 1 Score: 144.05 bits (362), Expect = 1.325e-35
Identity = 75/197 (38.07%), Postives = 119/197 (60.41%), Query Frame = 1

Query: 1117 GELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDM--NLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDM 1665
            G+L+G+GAFG V+ C   ++ +   +K +        ++ ++  +E  I   +  LCH RI+QY+G ++D M   L IFME++  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  +  N+KL DFG SR L     S +   S+TGT Y+ +PE+ S + Y    D+W+VG T+++M
Sbjct:  392 GKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPESPETSKEVSALECEIQLLK-NLCHERIVQYYGCLRDTMERTLSIFMEHMPGGSIKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEM 587

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290])

HSP 1 Score: 141.354 bits (355), Expect = 8.256e-35
Identity = 86/266 (32.33%), Postives = 147/266 (55.26%), Query Frame = 1

Query: 1105 TFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYI--------SNNQMKYIENNINKYREKLCHPRIIQYFGSIQD--DMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELN----SNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRK------EIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK----AFIQI 1830
            T+ +G+L+G+GAFG V+ C   ++ +    K +        ++ ++  +E  I   +  L H RI+QY+G ++D  +  L IFMEY+  GS+ D ++    L E  T  Y++QI+EG+++LH N I+HRDIK  NIL  ++ N+KL DFG S+ L     S +   S+TGT Y+ +PE+ S + Y    D+W++G T+++M   K      E  + +          +  S+ S++ + F    ++ ++K RP+AE+     F QI
Sbjct:  352 TWRRGKLLGQGAFGLVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLK-NLHHERIVQYYGCLRDHSEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPLLPSHTSDQARDFI-HCIFVEAKHRPSAEELLRHPFSQI 615

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000022068.2 (serine/threonine-protein kinase 24 [Source:NCBI gene;Acc:105356828])

HSP 1 Score: 131.339 bits (329), Expect = 1.256e-32
Identity = 87/248 (35.08%), Postives = 127/248 (51.21%), Query Frame = 1

Query: 1099 EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKL--CH-PRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAI-SLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG-----KDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            E+ F K + IGKG+FGEVFK     + K   IK I   + +    +I +    L  CH P I +YFGS      L I MEYL  GS  DL++ G PL E +     ++I++GL +LH    IHRDIK  N+LL     +KLADFG++ +L        +  GT ++ APE+  +  Y    D+W++GIT ++++  +   S L P          N      N S+ +K F  + L  D   RPTA++
Sbjct:   19 EEMFTKLDRIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCHSPFITKYFGSYLKSTKLWIIMEYLGGGSALDLLEPG-PLDETQIATILREILKGLEYLHSEKKIHRDIKAANVLLSEQGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSSYDSKADIWSLGITAIELAKGEPPHSDLHPMKVLFLIPKNNPPTLEGNYSKALKEFIEACLNKDPSFRPTAKE 265

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: tnni3k (serine/threonine-protein kinase TNNI3K [Source:NCBI gene;Acc:101167026])

HSP 1 Score: 135.191 bits (339), Expect = 1.826e-32
Identity = 136/526 (25.86%), Postives = 249/526 (47.34%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLIN--SECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDW--RPVHYATHKNSVKVLSMLIKAGC--NIEARNKWNMRSIHIAAKSG-NVDVLRVLL-ENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQ---CDIEACD-------KDKRKAIHWACLNNFLEVIKLLTKCQCRVDDR----------DG-YNYLPIDI----SRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKY-RE-----KLCHPRIIQYFGSIQDDMN-LLIFMEYLEQGSLSDLIQLGAPLMELKT-VNYSKQIIEGLAFLH--KNHIIHRDIKPQNILLKNSENIKLADFGLSRELNS--NSYAISLTGTVYYFAPEIWSE-QRYKYPTDLWAVGITILDMSCRKEIRSKLKP 1701
             PL  A  KG  ++ K L+  G D+ A  E   R +H A  +  + IVK L+   S+ N  A D +   P+H+  +  +++II+ L+  + +I+    N +   P+H A +   V  +  L++     ++   N ++  ++H A   G ++++++ LL +N  +I  + R    A+H A  +G I++++ L+      ++ ACD       KD++  + WA       ++ LL   + R DD           DG Y  +P  +    S TK+  E++ L   A   +H    F+L+  E                E  E+IG G+FG V++    N   A + +Y +N      +++++ + RE     +L HP IIQ+ G+  DD +   I  +Y+  GSL  L+     L++L++ +  +  + +G+ +LH     IIHRD+   NILL    +  +ADFG SR L S          G + + APE++++  RY    D+++  + + ++   +   + LKP
Sbjct:  169 TPLHIASYKGHEQVTKLLLKFGADVNASGEVGDRPLHLAAAKGFLAIVKLLMGDGSKANANAQDNEDHVPLHFCTRYGHHEIIRFLLQGNFDIQPHSVNIYGDTPLHLACYNGKVAAVKELVQLSGPESLPKENIFSETALHSACTYGKDLEMVKFLLNQNAMSINYQGRDGHTALHSACFHGHIRLVQFLLDSGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYK-RPDDSPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKAEVLVL--RASLPSH----FHLQLSEL---------------EFNEIIGSGSFGRVYRGKCRNKIVA-IKRYRANTYCS--KSDVDMFCREVSILCRLNHPCIIQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRLIDLQSKLIIAIDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSVDEDNMTKQPGNLRWMAPEVFTQCTRYSVKADMFSYALCLWELLTGEIPFAHLKP 669

HSP 2 Score: 77.411 bits (189), Expect = 3.380e-14
Identity = 55/237 (23.21%), Postives = 105/237 (44.30%), Query Frame = 1

Query:  277 ACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAG--CNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEAR--DRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKD---KRKAIHWACL-NNFLEVIKLL---TKCQCRVDDRDGYNYL 954
            A  K + +L   L+  G D++        A+H A    H +    L+    N+   D     P+H +  + + Q+ K+L+    ++ A  E   RP+H A  K  + ++ +L+  G   N  A++  +   +H   + G+ +++R LL+ N +I+    + +    +H A   GK+  ++ L++    E+  K+      A+H AC     LE++K L            RDG+  L
Sbjct:  108 AAFKDNAQLVTALLHGGADVQQVGYGALTALHVATLAGHHETADILLQHGANVNVQDAVFFTPLHIASYKGHEQVTKLLLKFGADVNASGEVGDRPLHLAAAKGFLAIVKLLMGDGSKANANAQDNEDHVPLHFCTRYGHHEIIRFLLQGNFDIQPHSVNIYGDTPLHLACYNGKVAAVKELVQLSGPESLPKENIFSETALHSACTYGKDLEMVKFLLNQNAMSINYQGRDGHTAL 344

HSP 3 Score: 73.1738 bits (178), Expect = 6.449e-13
Identity = 56/254 (22.05%), Postives = 116/254 (45.67%), Query Frame = 1

Query:  364 AIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENN--CNIEARDRWNKRAIHWAAQYGKIKILELLIK-QCDIEACDKD--KRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPID--ISRTK--------KAVEIVNLL--EEAMTINHISEAFNLKCEEFCDH 1074
            A+H A  +++  +V  L++   +++         +H +    +++   IL+ +  N+  +D   + P+H A++K   +V  +L+K G ++ A  +   R +H+AA  G + ++++L+ +    N  A+D  +   +H+  +YG  +I+  L++   DI+    +      +H AC N  +  +K L +         G   LP +   S T         K +E+V  L  + AM+IN+     +      C H
Sbjct:  104 ALHLAAFKDNAQLVTALLHGGADVQQVGYGALTALHVATLAGHHETADILLQHGANVNVQDAVFFTPLHIASYKGHEQVTKLLLKFGADVNASGEVGDRPLHLAAAKGFLAIVKLLMGDGSKANANAQDNEDHVPLHFCTRYGHHEIIRFLLQGNFDIQPHSVNIYGDTPLHLACYNGKVAAVKELVQLS-------GPESLPKENIFSETALHSACTYGKDLEMVKFLLNQNAMSINYQGRDGHTALHSACFH 350

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000022064.2 (serine/threonine-protein kinase 24 [Source:NCBI gene;Acc:105356828])

HSP 1 Score: 130.954 bits (328), Expect = 2.724e-32
Identity = 87/248 (35.08%), Postives = 127/248 (51.21%), Query Frame = 1

Query: 1099 EKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKL--CH-PRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAI-SLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG-----KDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            E+ F K + IGKG+FGEVFK     + K   IK I   + +    +I +    L  CH P I +YFGS      L I MEYL  GS  DL++ G PL E +     ++I++GL +LH    IHRDIK  N+LL     +KLADFG++ +L        +  GT ++ APE+  +  Y    D+W++GIT ++++  +   S L P          N      N S+ +K F  + L  D   RPTA++
Sbjct:   19 EEMFTKLDRIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCHSPFITKYFGSYLKSTKLWIIMEYLGGGSALDLLEPG-PLDETQIATILREILKGLEYLHSEKKIHRDIKAANVLLSEQGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSSYDSKADIWSLGITAIELAKGEPPHSDLHPMKVLFLIPKNNPPTLEGNYSKALKEFIEACLNKDPSFRPTAKE 265

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BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000016712.1 (SMESG000016712.1)

HSP 1 Score: 1165.6 bits (3014), Expect = 0.000e+0
Identity = 567/567 (100.00%), Postives = 567/567 (100.00%), Query Frame = 1

Query:  157 MSNSMFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEKAFIQINRFLRYFID 1857
            MSNSMFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEKAFIQINRFLRYFID
Sbjct:    1 MSNSMFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEKAFIQINRFLRYFID 567

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000016712.1 (SMESG000016712.1)

HSP 1 Score: 1156.35 bits (2990), Expect = 0.000e+0
Identity = 563/563 (100.00%), Postives = 563/563 (100.00%), Query Frame = 1

Query:  169 MFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEKAFIQINRFLRYFID 1857
            MFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEKAFIQINRFLRYFID
Sbjct:    1 MFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEKAFIQINRFLRYFID 563

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000016712.1 (SMESG000016712.1)

HSP 1 Score: 1154.81 bits (2986), Expect = 0.000e+0
Identity = 567/581 (97.59%), Postives = 567/581 (97.59%), Query Frame = 1

Query:  157 MSNSMFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMT--------------INHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEKAFIQINRFLRYFID 1857
            MSNSMFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMT              INHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEKAFIQINRFLRYFID
Sbjct:    1 MSNSMFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTKLPVEKVLGQKDWRINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPTAEKAFIQINRFLRYFID 581

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000017261.1 (SMESG000017261.1)

HSP 1 Score: 383.259 bits (983), Expect = 8.914e-124
Identity = 220/554 (39.71%), Postives = 321/554 (57.94%), Query Frame = 1

Query:  265 PLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDR------------WNKRAIH--------WAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYISNNQM--KYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSREL----NSNSYAISLTGTVYYFAPEIW----SEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFG-----KDVN--EIINSSNLSERMKLFTGSLLYHDSKLRPTAEK 1815
            P+  AC++G  +  K LI+  CDIEA D++ RR IH AC + H + VK LI   C++EA DV   RPIHY+C Q + + +K+LI + C+IEA D  + RP+HYA ++   + + +LI+  C+IEA ++WN R IH A   G+ + +++L+EN C+IEA D              N+R IH         A + G +K +   +    IE CDKD+R+ IHWAC +  ++V+K L K +C +  RD  N  P+DI+   +  E+V LL +A  +        LKC+ FC+H+LC  SL +KTF+KG  IG GAFG V+KC  +  +  F +K+I   ++  K IE NINK+  KL H RII+YFG+IQ + +L IFMEYL  GSL D I+    L     + YSKQI+EGL FLH N+IIHRDIKP NIL+ N  NIK+ DFG+SR L     + + A +  GT  + APE++        Y    D+W++G T+++M   +       P+       D    ++ +S ++S+ MK F   +L  D   R TA +
Sbjct:   72 PIHLACDQGRSEAVKLLIEHKCDIEALDKRNRRPIHLACYQGHSEAVKLLIEHNCDIEALDVWNLRPIHYACYQGHSEAVKLLIEHKCDIEAFDWWNQRPIHYACYQGRSEAVKLLIEHKCDIEAIDEWNQRPIHHACDQGHSEAVKLLIENKCDIEALDESGDSPMEIAVKSHNERIIHILNGPCLLRACKNGDLKKVSTYLNGAAIEYCDKDQRRPIHWACESGNIKVVKSLIKTKCDISARDKSNLSPLDIAIKNQNKELVELL-KAEELEQQILMMGLKCKSFCNHRLCNTSLRKKTFDKGSEIGSGAFGHVYKCKGSGIDTVFAVKWIELKKIGVKCIEENINKFLPKLNHQRIIKYFGAIQTEDHLCIFMEYLSGGSLEDEIKRKRSLATENIIRYSKQILEGLEFLHGNNIIHRDIKPDNILMSNGNNIKITDFGVSRSLLRTCGNVTKAETTIGTPNFTAPEVFLTSDEGPPYTVSADIWSLGATVINMITGRPPYCGCHPYAVVKKIADTKKLDLPDSQSMSKEMKEFIEKMLDPDPDQRSTAAQ 624

HSP 2 Score: 166.777 bits (421), Expect = 2.249e-43
Identity = 85/225 (37.78%), Postives = 139/225 (61.78%), Query Frame = 1

Query:  334 IEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIK-QCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLL 1005
            +E KD      IH AC   H +IVK LI   C++EA D + +RPIH +C Q   + +K+LI + C+IEA D+ + RP+H A ++   + + +LI+  C+IEA + WN+R IH A   G+ + +++L+E+ C+IEA D WN+R IH+A   G+ + ++LLI+ +CDIEA D+  ++ IH AC     E +KLL + +C ++  D     P++I+       I+++L
Sbjct:   29 LERKDADLWSPIHHACFAGHAEIVKLLIEHNCDIEALDKRNQRPIHLACDQGRSEAVKLLIEHKCDIEALDKRNRRPIHLACYQGHSEAVKLLIEHNCDIEALDVWNLRPIHYACYQGHSEAVKLLIEHKCDIEAFDWWNQRPIHYACYQGRSEAVKLLIEHKCDIEAIDEWNQRPIHHACDQGHSEAVKLLIENKCDIEALDESGDSPMEIAVKSHNERIIHIL 253

[Close]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Match: SMESG000017196.1 (SMESG000017196.1)

HSP 1 Score: 383.259 bits (983), Expect = 4.742e-122
Identity = 218/608 (35.86%), Postives = 324/608 (53.29%), Query Frame = 1

Query:  262 VPLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIK-QCD----------------------------------------------------IEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISE---------------AFNLKCEEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIK--YISNNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSDLIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENIKLADFGLSRE-LNSNSYAI---SLTGTVYYFAPEIW----SEQRYKYPTDLWAVGITILDMSCRKEIRSKLKPFGKDVN-------------EIINSSNLSERMKLFTGSLLYHDSKLRPTAE 1812
            +P+ +AC  G  ++ K LID  CD+EA+D    R IH ACK   +DI+K LI+  C++EA D   +RPIHY+C++E  +++K+LI + CNIEA D + WRP+HYA     ++++ +LI   C+IEA ++W  R IH A  + + + +++L+ ++C+IEA D W  R IH A   G I+ + LLI   CD                                                    IE CDK +R+ IHWAC +  +E++KLL K +C++  +D  +  P+DI+R     E+V ++++A+ +                    A  LKC  FCDH+LCP SL   +FEKG  IG G+ G ++KC  + ++K F +K   + +   KY+E NI K+  KL H RII+YFG+I  D  L IFMEY  +G+L D I+    L     + YSKQI+EGL FLH N IIHRDIKP NI++ +  +IKLADFG+SR  L +N  A    ++ GT+ + APE+         Y    D+W++G T+++M   K       P+   +              E+ NS  +SE MK F   +L  D   R TA+
Sbjct:  171 MPIHHACSVGHIEIVKLLIDHHCDVEARDNSGWRPIHHACKEKFIDIIKLLIDHHCDIEAGDEWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVQRRPIHWACESGNIELVKLLIKSKCKITIKDKSDLSPLDIARRNDNKELVQVIKDAILVQEPERELELERQEQVEKLIVAMGLKCTAFCDHRLCPTSLRNLSFEKGSKIGIGSCGMIYKCKGSGTDKVFAVKRTVLYDISQKYVEGNIYKFLPKLNHQRIIKYFGAILMDDRLCIFMEYFSEGTLEDEIKRKIFLTRENIIRYSKQILEGLEFLHGNSIIHRDIKPSNIMMTSDNDIKLADFGISRSLLRTNGLATRPATIAGTLNFIAPEVILASDDGAPYTESADIWSMGATVINMITGK------PPYYNSITPALIFKIASTKKLELPNSQLMSEEMKEFIEEMLNPDPDKRSTAK 772

HSP 2 Score: 206.453 bits (524), Expect = 1.782e-56
Identity = 111/278 (39.93%), Postives = 170/278 (61.15%), Query Frame = 1

Query:  190 QSIVNTSPENFQIICSPMDLEKISV----PLINACEKGDFKLAKFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEAR-NKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLI-KQCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLL 1005
            +SI + S E F        LE+  +    P+ +AC  G   + K LID  CDIEA D    R IH AC+  H +IVK LI+  C++EA D    RPIH++C+  + +I+K+LI + C+IEA DE+ WRP+H+AT+K    ++ +LI   C+IE+R N WN   IH A   G+++++++L++++C++EARD    R IH A +   I I++LLI   CDIEA D+ KR+ IH+AC   ++E++KLL    C ++  D   + PI  +   + +EIV LL
Sbjct:   10 ESIRSGSAELFHKYFKEEFLEREGIERVRPIHHACSAGHIDIVKLLIDHNCDIEAIDALGLRPIHHACRIGHTEIVKLLIDHFCDIEALDALGLRPIHHACRIGHTEIVKLLIDHYCDIEACDESGWRPIHHATNKGQTGIVKLLIDCHCDIESRDNWWNRMPIHHACSVGHIEIVKLLIDHHCDVEARDNSGWRPIHHACKEKFIDIIKLLIDHHCDIEAGDEWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLL 287

HSP 3 Score: 177.948 bits (450), Expect = 1.348e-46
Identity = 97/249 (38.96%), Postives = 150/249 (60.24%), Query Frame = 1

Query:  265 PLINACEKGDFKLAKFLIDSGCDIEAKDEK-KRRAIHWACKRNHVDIVKFLINSECNLEACDVKLKRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLSMLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNKRAIHWAAQYGKIKILELLIK-QCDIEACDKDKRKAIHWACLNNFLEVIKLLTKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLL 1005
            P+ +A  KG   + K LID  CDIE++D    R  IH AC   H++IVK LI+  C++EA D    RPIH++CK++   IIK+LI + C+IEA DE   RP+HYA  +  ++++ +LI   CNIEA ++   R IH A  + +++++++L++ +C+IEA DRW +R IH+A      + ++LLI   CDIEA D+   + IH AC    +E + LL    C +   D     PI+I+      EI+++L
Sbjct:  138 PIHHATNKGQTGIVKLLIDCHCDIESRDNWWNRMPIHHACSVGHIEIVKLLIDHHCDVEARDNSGWRPIHHACKEKFIDIIKLLIDHHCDIEAGDEWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVL 386

The following BLAST results are available for this feature:

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MAP3K3	5.458e-34	32.42	mitogen-activated protein kinase kinase kinase 3 [...	[more]
MAP3K3	5.774e-34	32.42	mitogen-activated protein kinase kinase kinase 3 [...	[more]
MAP3K3	5.842e-34	32.42	mitogen-activated protein kinase kinase kinase 3 [...	[more]
MAP3K3	5.967e-34	32.42	mitogen-activated protein kinase kinase kinase 3 [...	[more]
MAP3K3	5.967e-34	32.42	mitogen-activated protein kinase kinase kinase 3 [...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gck-1	2.433e-29	31.68	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]
gck-1	1.230e-28	30.97	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]
gck-1	2.388e-28	31.60	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]
gck-1	5.035e-28	31.60	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]
gck-2	1.633e-27	36.08	Mitogen-activated protein kinase kinase kinase kin...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GckIII	3.013e-30	31.23	gene:FBgn0266465 transcript:FBtr0083399	[more]
Ank2	4.945e-29	28.29	gene:FBgn0261788 transcript:FBtr0334061	[more]
Ank2	5.387e-29	28.29	gene:FBgn0261788 transcript:FBtr0303119	[more]
hppy	5.967e-27	32.58	gene:FBgn0263395 transcript:FBtr0340456	[more]
bt	6.074e-27	30.26	gene:FBgn0005666 transcript:FBtr0334482	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map3k3	2.627e-36	33.08	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k3	2.689e-36	33.08	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k3	3.175e-36	33.08	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k2	1.655e-34	37.56	mitogen-activated protein kinase kinase kinase 2 [...	[more]
map3k2	1.867e-34	37.56	mitogen-activated protein kinase kinase kinase 2 [...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
samd8	1.118e-35	33.59	sterile alpha motif domain containing 8 [Source:Xe...	[more]
samd8	1.122e-35	33.59	sterile alpha motif domain containing 8 [Source:Xe...	[more]
MAP3K2	3.970e-35	33.20	mitogen-activated protein kinase kinase kinase 2 [...	[more]
MAP3K2	5.291e-35	32.68	mitogen-activated protein kinase kinase kinase 2 [...	[more]
dennd1a	1.102e-31	36.22	DENN domain containing 1A [Source:Xenbase;Acc:XB-G...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Map3k2	9.454e-35	33.47	mitogen-activated protein kinase kinase kinase 2 [...	[more]
Map3k3	7.810e-34	32.42	mitogen-activated protein kinase kinase kinase 3 [...	[more]
Stk24	6.733e-32	33.87	serine/threonine kinase 24 [Source:MGI Symbol;Acc:...	[more]
Map3k19	2.661e-31	33.99	mitogen-activated protein kinase kinase kinase 19 ...	[more]
Map3k19	4.207e-30	33.99	mitogen-activated protein kinase kinase kinase 19 ...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|F4HRJ4\|M3K3A_ARATH	4.838e-35	34.65	Mitogen-activated protein kinase kinase kinase 3 O...	[more]
sp\|Q99759\|M3K3_HUMAN	2.806e-33	32.42	Mitogen-activated protein kinase kinase kinase 3 O...	[more]
sp\|Q61084\|M3K3_MOUSE	5.463e-33	32.42	Mitogen-activated protein kinase kinase kinase 3 O...	[more]
sp\|Q9Y2U5\|M3K2_HUMAN	6.399e-33	32.54	Mitogen-activated protein kinase kinase kinase 2 O...	[more]
sp\|Q61083\|M3K2_MOUSE	3.071e-32	33.07	Mitogen-activated protein kinase kinase kinase 2 O...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0H3YJG2	3.925e-49	30.94	Slc42a-1 OS=Schmidtea mediterranea OX=79327 GN=slc...	[more]
A0A1F8VAI3	3.647e-40	24.82	Uncharacterized protein OS=Coxiella sp. RIFCSPHIGH...	[more]
T1EDA5	3.594e-39	39.20	Protein kinase domain-containing protein OS=Helobd...	[more]
A7S4G7	1.034e-37	35.97	Predicted protein (Fragment) OS=Nematostella vecte...	[more]
A0A1I8I3V2	6.122e-37	38.78	Protein kinase domain-containing protein OS=Macros...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map3k3	4.448e-36	33.08	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k3	4.448e-36	33.08	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k3	4.448e-36	33.08	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k2	7.622e-35	38.07	mitogen-activated protein kinase kinase kinase 2 [...	[more]
map3k19	2.823e-34	32.85	mitogen-activated protein kinase kinase kinase 19 ...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map3k2	1.797e-36	33.20	mitogen-activated protein kinase kinase kinase 2 [...	[more]
stk25a	8.372e-33	33.82	serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-G...	[more]
MAP4K3	6.141e-29	31.64	mitogen-activated protein kinase kinase kinase kin...	[more]
map3k19	5.625e-28	28.64	mitogen-activated protein kinase kinase kinase 19 ...	[more]
ENSPMAT00000006402.1	8.351e-28	30.33	pep scaffold:Pmarinus_7.0:GL481397:10373:21355:-1 ...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
MKK1	4.129e-30	35.71	MAPKK involved in the protein kinase C signaling p...	[more]
MKK2	1.900e-29	36.46	MAPKK involved in the protein kinase C signaling p...	[more]
TPK2	1.386e-26	32.46	cAMP-dependent protein kinase catalytic subunit; p...	[more]
CDC15	8.470e-26	31.67	Protein kinase of the Mitotic Exit Network; locali...	[more]
BCK1	8.959e-25	33.81	MAPKKK acting in the protein kinase C signaling pa...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO41410	1.361e-41	35.97	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47821	2.002e-32	30.42	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49690	2.431e-32	38.22	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33652	6.384e-28	31.63	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31934	3.408e-27	31.85	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map3k2	1.325e-35	38.07	mitogen-activated protein kinase kinase kinase 2 [...	[more]
map3k3	8.256e-35	32.33	mitogen-activated protein kinase kinase kinase 3 [...	[more]
ENSORLT00000022068.2	1.256e-32	35.08	serine/threonine-protein kinase 24 [Source:NCBI ge...	[more]
tnni3k	1.826e-32	25.86	serine/threonine-protein kinase TNNI3K [Source:NCB...	[more]
ENSORLT00000022064.2	2.724e-32	35.08	serine/threonine-protein kinase 24 [Source:NCBI ge...	[more]

BLAST of Mitogen-activated protein kinase kinase kinase 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000016712.1	0.000e+0	100.00	SMESG000016712.1	[more]
SMESG000016712.1	0.000e+0	100.00	SMESG000016712.1	[more]
SMESG000016712.1	0.000e+0	97.59	SMESG000016712.1	[more]
SMESG000017261.1	8.914e-124	39.71	SMESG000017261.1	[more]
SMESG000017196.1	4.742e-122	35.86	SMESG000017196.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30018153 ID=SMED30018153|Name=Mitogen-activated protein kinase kinase kinase 3|organism=Schmidtea mediterranea sexual|type=transcript|length=2131bp
CTTAAATTTCATCCATAATAAATATTTAATTCAATTTTTTTTATAATTTT
ATTGATCTAAGTCATTTTATCAATTTCACAGTTTTCTACAGTGTTTTTAA
TAATTTATTCAATTGGTTAACAATTTATTTAATCAAATTATTGTTGTGAA
ACTAAAATGTCCAATTCAATGTTCAATATTGGTAGTTTTCAATCGATTGT
CAACACATCTCCGGAAAATTTTCAAATAATTTGTAGTCCAATGGATCTGG
AGAAGATATCTGTACCTTTAATTAACGCTTGTGAAAAAGGCGATTTTAAG
CTTGCAAAATTTCTAATTGACTCAGGATGTGATATAGAAGCAAAAGATGA
AAAAAAGAGAAGAGCAATTCATTGGGCATGTAAGAGAAATCACGTTGATA
TTGTAAAATTTCTTATAAACAGTGAGTGCAATCTCGAGGCTTGTGATGTG
AAACTGAAACGACCGATTCACTATTCATGCAAACAAGAAAATTATCAAAT
TATCAAAATTCTGATCACGAATGACTGCAATATTGAAGCTCGAGATGAGA
ATGATTGGCGGCCAGTTCATTACGCCACACATAAAAATTCTGTCAAAGTA
CTTTCAATGCTGATTAAAGCTGGATGCAACATTGAAGCAAGGAATAAATG
GAATATGCGGTCAATTCACATTGCTGCAAAAAGTGGTAACGTAGACGTTT
TAAGGGTTTTATTAGAAAACAATTGTAACATTGAAGCTCGAGACAGGTGG
AATAAAAGAGCCATTCATTGGGCTGCCCAATACGGAAAAATAAAAATTCT
CGAATTATTAATCAAACAGTGCGACATCGAAGCTTGTGATAAAGACAAAA
GAAAAGCAATTCACTGGGCATGTTTAAATAATTTCCTTGAAGTGATAAAA
CTACTTACAAAATGTCAGTGCCGCGTTGACGATCGTGATGGATATAACTA
TTTACCGATAGATATTTCTAGAACAAAGAAAGCAGTAGAAATTGTTAATC
TATTAGAGGAAGCAATGACGATAAACCACATCAGTGAAGCTTTTAATTTG
AAATGTGAAGAATTCTGCGATCATAAACTATGTCCAAAGTCATTGTATGA
AAAAACATTTGAAAAAGGCGAACTTATCGGAAAAGGCGCATTTGGAGAGG
TTTTTAAATGTAATTTGACAAATTCAAACAAAGCATTTGTAATAAAATAT
ATATCTAATAACCAAATGAAATATATCGAAAACAACATTAATAAGTACCG
TGAAAAATTGTGCCATCCGAGAATAATTCAATATTTTGGATCTATTCAAG
ATGATATGAATTTATTGATTTTCATGGAATACCTGGAACAGGGCTCTTTA
AGTGATCTAATTCAACTTGGTGCTCCACTAATGGAGCTGAAAACCGTAAA
CTACAGTAAACAAATTATAGAAGGACTGGCATTCCTTCATAAAAATCACA
TTATTCACAGGGATATCAAACCACAAAATATCCTTTTGAAAAATTCTGAA
AATATTAAACTTGCTGATTTTGGCCTTAGTCGTGAACTTAATTCGAATAG
CTATGCGATTTCTTTGACCGGGACTGTTTATTACTTTGCTCCTGAAATCT
GGTCAGAACAACGTTATAAATATCCGACAGATTTATGGGCAGTTGGAATA
ACTATTTTAGACATGAGTTGTCGTAAGGAAATACGTTCTAAATTAAAACC
GTTTGGTAAAGATGTGAATGAAATTATTAATTCGTCGAACCTTTCAGAAC
GTATGAAGTTATTTACCGGTAGTTTATTATATCATGATTCAAAATTACGC
CCAACTGCTGAAAAAGCCTTTATACAAATCAACAGATTTCTGCGTTATTT
TATAGATTGATTTATTTTAAAAATTTAGTTTTATTTTTTCAATAAAAAAT
TTTTGTTGAAAATTTTATTTCTCATTTTAGTTACTCATATATTCATACAA
TCAAGGCCGGTTTTAAAATGAGCGAAATTCCTACTTTAACCTTTTATGGC
CTCTCATATAACAATTCCGCCGTTAAAACACTTTTGCTCCAATCTTATTA
CTTATTAAATTACAGTAACTAATAAATATCATCTCTTTATATTAAGATGA
CTATTTATTGCAATGGTTCCCAACCTGTGGG

protein sequence of SMED30018153-orf-1

>SMED30018153-orf-1 ID=SMED30018153-orf-1|Name=SMED30018153-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=568bp
MSNSMFNIGSFQSIVNTSPENFQIICSPMDLEKISVPLINACEKGDFKLA
KFLIDSGCDIEAKDEKKRRAIHWACKRNHVDIVKFLINSECNLEACDVKL
KRPIHYSCKQENYQIIKILITNDCNIEARDENDWRPVHYATHKNSVKVLS
MLIKAGCNIEARNKWNMRSIHIAAKSGNVDVLRVLLENNCNIEARDRWNK
RAIHWAAQYGKIKILELLIKQCDIEACDKDKRKAIHWACLNNFLEVIKLL
TKCQCRVDDRDGYNYLPIDISRTKKAVEIVNLLEEAMTINHISEAFNLKC
EEFCDHKLCPKSLYEKTFEKGELIGKGAFGEVFKCNLTNSNKAFVIKYIS
NNQMKYIENNINKYREKLCHPRIIQYFGSIQDDMNLLIFMEYLEQGSLSD
LIQLGAPLMELKTVNYSKQIIEGLAFLHKNHIIHRDIKPQNILLKNSENI
KLADFGLSRELNSNSYAISLTGTVYYFAPEIWSEQRYKYPTDLWAVGITI
LDMSCRKEIRSKLKPFGKDVNEIINSSNLSERMKLFTGSLLYHDSKLRPT
AEKAFIQINRFLRYFID*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR036770	Ankyrin_rpt-contain_sf
IPR000719	Prot_kinase_dom
IPR002110	Ankyrin_rpt
IPR020683	Ankyrin_rpt-contain_dom
IPR008271	Ser/Thr_kinase_AS
IPR017441	Protein_kinase_ATP_BS
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0005515	protein binding
GO:0000166	nucleotide binding
GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0016310	phosphorylation
GO:0023014	signal transduction by protein phosphorylation

Vocabulary: **cellular component**
Term	Definition
GO:0005737	cytoplasm

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 318..562 e-value: 8.2E-60 score: 214.7
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 318..554 e-value: 3.7E-56 score: 190.4
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 318..562 score: 40.767
IPR002110	Ankyrin repeat	SMART	SM00248	ANK_2a	coord: 230..259 e-value: 1.3 score: 18.0 coord: 99..128 e-value: 5.6 score: 15.9 coord: 33..62 e-value: 13.0 score: 14.8 coord: 198..226 e-value: 31.0 score: 13.5 coord: 165..194 e-value: 0.61 score: 19.1 coord: 66..95 e-value: 0.0088 score: 25.2 coord: 132..161 e-value: 0.23 score: 20.6
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 132..164 score: 10.339
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 33..65 score: 9.244
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 99..131 score: 8.763
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 165..197 score: 10.873
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 66..98 score: 8.63
None	No IPR available	PIRSF	PIRSF000654	ILK	coord: 134..221 e-value: 3.5E-15 score: 53.2 coord: 201..535 e-value: 9.6E-44 score: 147.4 coord: 98..170 e-value: 1.3E-8 score: 31.6 coord: 17..121 e-value: 4.9E-10 score: 36.3
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 314..563 e-value: 2.8E-64 score: 219.0
None	No IPR available	PANTHER	PTHR24193	ANKYRIN REPEAT PROTEIN	coord: 130..220 coord: 37..119 coord: 169..290 coord: 102..181
IPR020683	Ankyrin repeat-containing domain	PFAM	PF12796	Ank_2	coord: 38..130 e-value: 5.1E-15 score: 55.8 coord: 170..260 e-value: 6.0E-14 score: 52.4
IPR020683	Ankyrin repeat-containing domain	PROSITE	PS50297	ANK_REP_REGION	coord: 33..283 score: 50.48
IPR036770	Ankyrin repeat-containing domain superfamily	GENE3D	G3DSA:1.25.40.20		coord: 27..306 e-value: 8.0E-67 score: 227.6
IPR036770	Ankyrin repeat-containing domain superfamily	SUPERFAMILY	SSF48403	Ankyrin repeat	coord: 37..285
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 324..347
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 432..444
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 313..555