Metabotropic glutamate receptor 8
Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017942 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Human
Match: GRM8 (glutamate metabotropic receptor 8 [Source:HGNC Symbol;Acc:HGNC:4600]) HSP 1 Score: 50.8322 bits (120), Expect = 2.288e-7 Identity = 43/144 (29.86%), Postives = 63/144 (43.75%), Query Frame = 3 Query: 60 KKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 KKC ++I + ++ I +Y ++ + + + K C IGL + DGK LL Y++AVNF G A + FN+ GD Y IFQ Q STE +G W LK+ + C + C P E Sbjct: 382 KKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST-IDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGE 524
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Human
Match: GRM8 (glutamate metabotropic receptor 8 [Source:HGNC Symbol;Acc:HGNC:4600]) HSP 1 Score: 48.1358 bits (113), Expect = 1.840e-6 Identity = 43/144 (29.86%), Postives = 63/144 (43.75%), Query Frame = 3 Query: 60 KKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQ---TSTELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 KKC ++I + ++ I +Y ++ + + + K C IGL + DGK LL Y++AVNF G A + FN+ GD Y IFQ Q STE +G W LK+ + C + C P E Sbjct: 382 KKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMS-TIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGE 524
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Human
Match: GRM8 (glutamate metabotropic receptor 8 [Source:HGNC Symbol;Acc:HGNC:4600]) HSP 1 Score: 48.1358 bits (113), Expect = 1.840e-6 Identity = 43/144 (29.86%), Postives = 63/144 (43.75%), Query Frame = 3 Query: 60 KKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQ---TSTELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 KKC ++I + ++ I +Y ++ + + + K C IGL + DGK LL Y++AVNF G A + FN+ GD Y IFQ Q STE +G W LK+ + C + C P E Sbjct: 382 KKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMS-TIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGE 524
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Human
Match: GRM7 (glutamate metabotropic receptor 7 [Source:HGNC Symbol;Acc:HGNC:4599]) HSP 1 Score: 46.595 bits (109), Expect = 6.145e-6 Identity = 41/161 (25.47%), Postives = 68/161 (42.24%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAP 467 E F C S ++ +KC ++I + ++ I +Y ++ + + ++K C G+ E+ GK LL+Y++ VNF G A + FN+ GD Y IFQ QT+ P +G W + L + V C + C P Sbjct: 370 ENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQA-GGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKP 529
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Human
Match: GRM7 (glutamate metabotropic receptor 7 [Source:HGNC Symbol;Acc:HGNC:4599]) HSP 1 Score: 46.595 bits (109), Expect = 6.270e-6 Identity = 41/161 (25.47%), Postives = 68/161 (42.24%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAP 467 E F C S ++ +KC ++I + ++ I +Y ++ + + ++K C G+ E+ GK LL+Y++ VNF G A + FN+ GD Y IFQ QT+ P +G W + L + V C + C P Sbjct: 370 ENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQA-GGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKP 529
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Zebrafish
Match: grm6b (glutamate receptor, metabotropic 6b [Source:ZFIN;Acc:ZDB-GENE-021120-2]) HSP 1 Score: 46.595 bits (109), Expect = 3.793e-6 Identity = 31/82 (37.80%), Postives = 44/82 (53.66%), Query Frame = 3 Query: 171 LDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVWYGDQGLKLN 401 +D C S+G+ ++ DG++LL Y++AVNF G A + FN+ GD Y IFQ Q S P +G W L+LN Sbjct: 397 IDLCPGSMGVCDKMDPV-DGRMLLTYIRAVNFNGSAGTGVMFNENGDAPGRYDIFQYQLSNTTNPGYKLIGQW--TNHLRLN 475
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Zebrafish
Match: grm6b (glutamate receptor, metabotropic 6b [Source:ZFIN;Acc:ZDB-GENE-021120-2]) HSP 1 Score: 46.595 bits (109), Expect = 4.380e-6 Identity = 28/73 (38.36%), Postives = 40/73 (54.79%), Query Frame = 3 Query: 171 LDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVW 374 +D C S+G+ ++ DG++LL Y++AVNF G A + FN+ GD Y IFQ Q S P +G W Sbjct: 436 IDLCPGSMGVCDKMDPV-DGRMLLTYIRAVNFNGSAGTGVMFNENGDAPGRYDIFQYQLSNTTNPGYKLIGQW 507
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Zebrafish
Match: grm6b (glutamate receptor, metabotropic 6b [Source:ZFIN;Acc:ZDB-GENE-021120-2]) HSP 1 Score: 46.595 bits (109), Expect = 4.380e-6 Identity = 28/73 (38.36%), Postives = 40/73 (54.79%), Query Frame = 3 Query: 171 LDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVW 374 +D C S+G+ ++ DG++LL Y++AVNF G A + FN+ GD Y IFQ Q S P +G W Sbjct: 436 IDLCPGSMGVCDKMDPV-DGRMLLTYIRAVNFNGSAGTGVMFNENGDAPGRYDIFQYQLSNTTNPGYKLIGQW 507
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Zebrafish
Match: grm6b (glutamate receptor, metabotropic 6b [Source:ZFIN;Acc:ZDB-GENE-021120-2]) HSP 1 Score: 46.595 bits (109), Expect = 4.382e-6 Identity = 28/73 (38.36%), Postives = 40/73 (54.79%), Query Frame = 3 Query: 171 LDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVW 374 +D C S+G+ ++ DG++LL Y++AVNF G A + FN+ GD Y IFQ Q S P +G W Sbjct: 440 IDLCPGSMGVCDKMDPV-DGRMLLTYIRAVNFNGSAGTGVMFNENGDAPGRYDIFQYQLSNTTNPGYKLIGQW 511
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Zebrafish
Match: grm6b (glutamate receptor, metabotropic 6b [Source:ZFIN;Acc:ZDB-GENE-021120-2]) HSP 1 Score: 46.595 bits (109), Expect = 4.382e-6 Identity = 28/73 (38.36%), Postives = 40/73 (54.79%), Query Frame = 3 Query: 171 LDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVW 374 +D C S+G+ ++ DG++LL Y++AVNF G A + FN+ GD Y IFQ Q S P +G W Sbjct: 440 IDLCPGSMGVCDKMDPV-DGRMLLTYIRAVNFNGSAGTGVMFNENGDAPGRYDIFQYQLSNTTNPGYKLIGQW 511
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Xenopus
Match: ENSXETT00000053241.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:2:79464981:79849474:-1 gene:ENSXETG00000017572.1 transcript:ENSXETT00000053241.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 50.0618 bits (118), Expect = 4.220e-7 Identity = 40/138 (28.99%), Postives = 66/138 (47.83%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLN 401 + F C +S KKC + ++I ++ I +Y ++ + + + K C S+GL S + DG LL+Y+++VNF G+A + FN+ GD Y I+Q Q STE +G W LK++ Sbjct: 358 DNFHCRLSRNSLRRGGHGKKCTNQERIGVGSAYEQEGKVQFVIDAVYSMAYALHTMHKTVCPGSVGLCSRMDPV-DGVELLKYIRSVNFTGIAGTPVTFNENGDAPGRYEIYQYQINNGSTEYRVIGQWADHLHLKID 494
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Xenopus
Match: ENSXETT00000053239.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:2:79387181:79787707:-1 gene:ENSXETG00000017572.1 transcript:ENSXETT00000053239.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 50.0618 bits (118), Expect = 4.269e-7 Identity = 40/138 (28.99%), Postives = 66/138 (47.83%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLN 401 + F C +S KKC + ++I ++ I +Y ++ + + + K C S+GL S + DG LL+Y+++VNF G+A + FN+ GD Y I+Q Q STE +G W LK++ Sbjct: 351 DNFHCRLSRNSLRRGGHGKKCTNQERIGVGSAYEQEGKVQFVIDAVYSMAYALHTMHKTVCPGSVGLCSRMDPV-DGVELLKYIRSVNFTGIAGTPVTFNENGDAPGRYEIYQYQINNGSTEYRVIGQWADHLHLKID 487
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Xenopus
Match: GRM8 (glutamate receptor, metabotropic 8 [Source:NCBI gene;Acc:100497088]) HSP 1 Score: 47.3654 bits (111), Expect = 3.705e-6 Identity = 43/162 (26.54%), Postives = 65/162 (40.12%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEI--IKDIVKLYGISISKYILDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 E F C + +F KKC ++I + ++ + D V +++ D C IGL + DGK LL Y++AVNF G A + FN+ GD Y I+Q Q + E +G W L + + C + C P E Sbjct: 370 ENFGCKLGSHGKRNNHF-KKCTGLERIGRHSSFEQEGKVQFVIDAVYSMAHALNNMHKDLCPGYIGLCPRMK-TIDGKELLSYIRAVNFNGSAGTPVTFNENGDAPGRYDIYQYQMTNKTAEYKVIGQWTNQLHLNVEDMQWTSREHTQPTSVCSLPCKPGE 529
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Xenopus
Match: GRM8 (glutamate receptor, metabotropic 8 [Source:NCBI gene;Acc:100497088]) HSP 1 Score: 46.9802 bits (110), Expect = 3.741e-6 Identity = 43/162 (26.54%), Postives = 65/162 (40.12%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEI--IKDIVKLYGISISKYILDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 E F C + +F KKC ++I + ++ + D V +++ D C IGL + DGK LL Y++AVNF G A + FN+ GD Y I+Q Q + E +G W L + + C + C P E Sbjct: 372 ENFGCKLGSHGKRNNHF-KKCTGLERIGRHSSFEQEGKVQFVIDAVYSMAHALNNMHKDLCPGYIGLCPRMKT-IDGKELLSYIRAVNFNGSAGTPVTFNENGDAPGRYDIYQYQMTNKTAEYKVIGQWTNQLHLNVEDMQWTSREHTQPTSVCSLPCKPGE 531
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Mouse
Match: Grm8 (glutamate receptor, metabotropic 8 [Source:MGI Symbol;Acc:MGI:1351345]) HSP 1 Score: 51.2174 bits (121), Expect = 9.943e-8 Identity = 43/144 (29.86%), Postives = 64/144 (44.44%), Query Frame = 3 Query: 60 KKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 KKC ++I + ++ I +Y ++ + + + K C IGL + + DGK LL Y++AVNF G A + FN+ GD Y IFQ Q STE +G W LK+ + C + C P E Sbjct: 382 KKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKELCPGYIGLCPRM-VTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGE 524
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Mouse
Match: Grm8 (glutamate receptor, metabotropic 8 [Source:MGI Symbol;Acc:MGI:1351345]) HSP 1 Score: 51.2174 bits (121), Expect = 9.943e-8 Identity = 43/144 (29.86%), Postives = 64/144 (44.44%), Query Frame = 3 Query: 60 KKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 KKC ++I + ++ I +Y ++ + + + K C IGL + + DGK LL Y++AVNF G A + FN+ GD Y IFQ Q STE +G W LK+ + C + C P E Sbjct: 382 KKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKELCPGYIGLCPRM-VTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGE 524
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Mouse
Match: Grm8 (glutamate receptor, metabotropic 8 [Source:MGI Symbol;Acc:MGI:1351345]) HSP 1 Score: 51.2174 bits (121), Expect = 1.023e-7 Identity = 43/144 (29.86%), Postives = 64/144 (44.44%), Query Frame = 3 Query: 60 KKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 KKC ++I + ++ I +Y ++ + + + K C IGL + + DGK LL Y++AVNF G A + FN+ GD Y IFQ Q STE +G W LK+ + C + C P E Sbjct: 382 KKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKELCPGYIGLCPRM-VTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGE 524
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Mouse
Match: Grm7 (glutamate receptor, metabotropic 7 [Source:MGI Symbol;Acc:MGI:1351344]) HSP 1 Score: 45.8246 bits (107), Expect = 7.398e-6 Identity = 41/161 (25.47%), Postives = 68/161 (42.24%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAP 467 E F C S ++ +KC ++I + ++ I +Y ++ + + ++K C G+ E+ GK LL+Y++ VNF G A + FN+ GD Y IFQ QT+ P +G W + L + V C + C P Sbjct: 370 ENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQA-GGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPPSVCTLPCKP 529
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Mouse
Match: Grm7 (glutamate receptor, metabotropic 7 [Source:MGI Symbol;Acc:MGI:1351344]) HSP 1 Score: 45.8246 bits (107), Expect = 8.767e-6 Identity = 41/161 (25.47%), Postives = 68/161 (42.24%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAP 467 E F C S ++ +KC ++I + ++ I +Y ++ + + ++K C G+ E+ GK LL+Y++ VNF G A + FN+ GD Y IFQ QT+ P +G W + L + V C + C P Sbjct: 370 ENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQA-GGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPPSVCTLPCKP 529
BLAST of Metabotropic glutamate receptor 8 vs. UniProt/SwissProt
Match: sp|P70579|GRM8_RAT (Metabotropic glutamate receptor 8 OS=Rattus norvegicus OX=10116 GN=Grm8 PE=1 SV=1) HSP 1 Score: 51.6026 bits (122), Expect = 6.759e-7 Identity = 42/144 (29.17%), Postives = 65/144 (45.14%), Query Frame = 3 Query: 60 KKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYIL--DKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 KKC ++I + ++ I +Y ++ + + + ++C IGL + + DGK LL Y++AVNF G A + FN+ GD Y IFQ Q STE +G W LK+ + C + C P E Sbjct: 382 KKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRM-VTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGE 524
BLAST of Metabotropic glutamate receptor 8 vs. UniProt/SwissProt
Match: sp|P47743|GRM8_MOUSE (Metabotropic glutamate receptor 8 OS=Mus musculus OX=10090 GN=Grm8 PE=1 SV=2) HSP 1 Score: 51.2174 bits (121), Expect = 7.157e-7 Identity = 43/144 (29.86%), Postives = 64/144 (44.44%), Query Frame = 3 Query: 60 KKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 KKC ++I + ++ I +Y ++ + + + K C IGL + + DGK LL Y++AVNF G A + FN+ GD Y IFQ Q STE +G W LK+ + C + C P E Sbjct: 382 KKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKELCPGYIGLCPRM-VTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGE 524
BLAST of Metabotropic glutamate receptor 8 vs. UniProt/SwissProt
Match: sp|O00222|GRM8_HUMAN (Metabotropic glutamate receptor 8 OS=Homo sapiens OX=9606 GN=GRM8 PE=1 SV=2) HSP 1 Score: 50.8322 bits (120), Expect = 1.099e-6 Identity = 43/144 (29.86%), Postives = 63/144 (43.75%), Query Frame = 3 Query: 60 KKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDK--CNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQT---STELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLE 473 KKC ++I + ++ I +Y ++ + + + K C IGL + DGK LL Y++AVNF G A + FN+ GD Y IFQ Q STE +G W LK+ + C + C P E Sbjct: 382 KKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMST-IDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGE 524
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Cavefish
Match: grm6b (metabotropic glutamate receptor 6-like [Source:NCBI gene;Acc:111195348]) HSP 1 Score: 50.0618 bits (118), Expect = 2.182e-7 Identity = 38/130 (29.23%), Postives = 58/130 (44.62%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEI--IKDIVKLYGISISKYILDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVW 374 ++FKC L +KC ++I ++ + D V ++ +D C S G+ + +GKLLL+Y++AVNF G A + FN+ GD Y IFQ Q S P +G W Sbjct: 373 DDFKCKLTRPGIKLDGGQRKCTGEERIGRHSPYEQEGKVQFVIDAVYAMAHALHSMHIDMCPGSTGICDSMDPV-EGKLLLKYIRAVNFNGSAGTGVMFNEDGDAPGRYDIFQYQLSNTTNPGYKNIGQW 501
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Cavefish
Match: GRM7 (glutamate metabotropic receptor 7 [Source:HGNC Symbol;Acc:HGNC:4599]) HSP 1 Score: 45.8246 bits (107), Expect = 6.491e-6 Identity = 41/139 (29.50%), Postives = 67/139 (48.20%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKI-TERKTDLL-NAEIIKDIVKLYGISISKYILDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVWYGDQGLKLN 401 E F C + SS ++ S+KC ++I T+ K + + + D V ++ D C G+ +E+ + GK LL+Y++ VNF G A + FN GD Y +FQ Q + +P +G W + L+LN Sbjct: 368 ENFNCKLMS-SSKKEDTSRKCTGQERIGTDSKYEQEGKVQFVIDAVYAMAHALHNMQKDLCPEHSGVCAEMEVA-GGKKLLKYIRNVNFNGSAGTSVTFNHNGDAPGRYDLFQYQMNNNSSPGYKVIGQW--TENLQLN 502
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Cavefish
Match: grm6a (glutamate receptor, metabotropic 6a [Source:ZFIN;Acc:ZDB-GENE-060208-1]) HSP 1 Score: 45.8246 bits (107), Expect = 6.612e-6 Identity = 40/140 (28.57%), Postives = 64/140 (45.71%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLN---AEIIKDIVKLYGISISKYILDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVWYGDQGLKLN 401 ++F+C L KKC ++I R T + + D V ++ D C +IG+ ++ +G+LLL Y+++VNF G A + FN+ GD Y IFQ Q + P +G W + L+LN Sbjct: 384 DDFRCKLTRPGIKLDPEKKKCTGNERIG-RDTPYEQEGKVQFVIDAVYAMAHALHNMHQDLCPGAIGVCDKMDPV-EGRLLLSYIRSVNFNGSAGTGVLFNENGDAPGRYDIFQYQMTNTSNPGYRVIGQWTNN--LRLN 519
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Medaka
Match: ENSORLT00000024870.2 (metabotropic glutamate receptor 6-like [Source:NCBI gene;Acc:101165214]) HSP 1 Score: 48.9062 bits (115), Expect = 5.460e-7 Identity = 40/139 (28.78%), Postives = 68/139 (48.92%), Query Frame = 3 Query: 6 EEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYIL--DKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLA-RKIYFNQFGDTDPIYSIFQQQTSTELTP----VGVWYGDQGLKLN 401 ++F+C L KKC ++I + + ++ I +Y ++ + + + D C S G+ S + +G+LLL+Y++AVNF G A + FN+ GD Y IFQ Q + P +G W + L+LN Sbjct: 374 DDFRCKLTRPGVKLDPEKKKCTGDERIGQDSSYEQEGKVQFVIDAVYAVAHALHNMHQDLCPGSHGVCSNMDPV-EGRLLLDYIRAVNFNGSAGTSVLFNENGDAPGRYDIFQFQMTNHSHPGYHVIGQWTNN--LRLN 509
BLAST of Metabotropic glutamate receptor 8 vs. Planmine SMEST
Match: SMESG000064459.1 (SMESG000064459.1) HSP 1 Score: 332.798 bits (852), Expect = 1.986e-110 Identity = 162/162 (100.00%), Postives = 162/162 (100.00%), Query Frame = 3 Query: 3 REEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLARKIYFNQFGDTDPIYSIFQQQTSTELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLEVMIRL 488 REEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLARKIYFNQFGDTDPIYSIFQQQTSTELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLEVMIRL Sbjct: 347 REEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGISISKYILDKCNYSIGLKSELYLCFDGKLLLEYLKAVNFQGLARKIYFNQFGDTDPIYSIFQQQTSTELTPVGVWYGDQGLKLNSALIEPSVNITIKIKCIMHCAPLEVMIRL 508 The following BLAST results are available for this feature:
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 4
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Metabotropic glutamate receptor 8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 3
BLAST of Metabotropic glutamate receptor 8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 0
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Metabotropic glutamate receptor 8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of Metabotropic glutamate receptor 8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017942 ID=SMED30017942|Name=Metabotropic glutamate receptor 8|organism=Schmidtea mediterranea sexual|type=transcript|length=490bpback to top protein sequence of SMED30017942-orf-1 >SMED30017942-orf-1 ID=SMED30017942-orf-1|Name=SMED30017942-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=162bp REEFKCFFQNDSSNLKNFSKKCEDFKKITERKTDLLNAEIIKDIVKLYGIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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