Cathepsin L2

Overview
NameCathepsin L2
Smed IDSMED30017940
Length (bp)1165
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cathepsin L2 (SMED30017940) t-SNE clustered cells

Violin plots show distribution of expression levels for Cathepsin L2 (SMED30017940) in cells (dots) of each of the 12 neoblast clusters.

 

back to top


 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cathepsin L2 (SMED30017940) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cathepsin L2 (SMED30017940) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top


 

Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020




SMED30017940

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parenchymal cellSMED30017940SMESG000049722.1 dd_Smed_v4_175_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30017940SMESG000049722.1 dd_175dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult fluorescence in situ hybridization evidence
parenchymal cellSMED30017940SMESG000049722.1 dd_Smed_v6_175_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30017940SMESG000049722.1 SMED_01490_V2_1rGPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30017940SMESG000049722.1 SMED_01490_V2_1rGPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538])

HSP 1 Score: 363.614 bits (932), Expect = 2.615e-124
Identity = 184/335 (54.93%), Postives = 234/335 (69.85%), Query Frame = 1
Query:  115 VLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++LA FC+  I++   KF+ N  L+ +W  +K   +R Y +  E  RR +WE+N+++I+ HN EY  GKH + + +N F DMTNEE+R +++G     K     +F  P   +DLPKSVDWR KGYVTPVKNQ  CGSCW+FS TG+LEGQ  RKTG+L+SLSEQ LVDCS+P GN GCNGG M  AFQY++++ GL+SEE Y Y A +  CKY     VA+ TGF  +  G EK L KAVATVGPISVA+DA   +FQ YK GIY E  CSS+ LDHGVL VGYG E    NN  +W+VKNSWGP+WG +GY+K+ KD++N CGIAT ASYP V
Sbjct:    5 LVLAAFCL-GIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPL-FLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538])

HSP 1 Score: 363.614 bits (932), Expect = 2.615e-124
Identity = 184/335 (54.93%), Postives = 234/335 (69.85%), Query Frame = 1
Query:  115 VLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++LA FC+  I++   KF+ N  L+ +W  +K   +R Y +  E  RR +WE+N+++I+ HN EY  GKH + + +N F DMTNEE+R +++G     K     +F  P   +DLPKSVDWR KGYVTPVKNQ  CGSCW+FS TG+LEGQ  RKTG+L+SLSEQ LVDCS+P GN GCNGG M  AFQY++++ GL+SEE Y Y A +  CKY     VA+ TGF  +  G EK L KAVATVGPISVA+DA   +FQ YK GIY E  CSS+ LDHGVL VGYG E    NN  +W+VKNSWGP+WG +GY+K+ KD++N CGIAT ASYP V
Sbjct:    5 LVLAAFCL-GIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPL-FLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 360.147 bits (923), Expect = 5.898e-123
Identity = 184/335 (54.93%), Postives = 228/335 (68.06%), Query Frame = 1
Query:  115 VLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++LA FC+  I++  L F+   +L  +W  +K    R Y    E  RR +WE+N+++I+ HN EY  GKHS+ + +N F DMT+EE+R  + G +  N+   +          + P+SVDWR KGYVTPVKNQ  CGSCW+FS TG+LEGQ  RKTG+LISLSEQ LVDCS P GN GCNGGLMD AFQY+Q + GL+SEE Y Y A E +CKY+    VA+ TGFVDI K  EK L KAVATVGPISVAIDA   +F  YK GIY E  CSS  +DHGVL VGYG E    +N  +W+VKNSWG +WG+ GY+KM KDR N CGIA+ ASYP V
Sbjct:    5 LILAAFCL-GIASATLTFD--HSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQ--NRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 360.147 bits (923), Expect = 5.898e-123
Identity = 184/335 (54.93%), Postives = 228/335 (68.06%), Query Frame = 1
Query:  115 VLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++LA FC+  I++  L F+   +L  +W  +K    R Y    E  RR +WE+N+++I+ HN EY  GKHS+ + +N F DMT+EE+R  + G +  N+   +          + P+SVDWR KGYVTPVKNQ  CGSCW+FS TG+LEGQ  RKTG+LISLSEQ LVDCS P GN GCNGGLMD AFQY+Q + GL+SEE Y Y A E +CKY+    VA+ TGFVDI K  EK L KAVATVGPISVAIDA   +F  YK GIY E  CSS  +DHGVL VGYG E    +N  +W+VKNSWG +WG+ GY+KM KDR N CGIA+ ASYP V
Sbjct:    5 LILAAFCL-GIASATLTFD--HSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQ--NRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSK (cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536])

HSP 1 Score: 321.627 bits (823), Expect = 5.210e-108
Identity = 160/334 (47.90%), Postives = 221/334 (66.17%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESII-ELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLK-PINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYP 1098
            +K++LL V                E L+  W ++K   +++Y + + E++RRLIWE+NL+ I  HN+E  LG H+Y L +N   DMT+EE   K+ GLK P++ + +      PE     P SVD+R KGYVTPVKNQ  CGSCW+FS+ G+LEGQ K+KTG+L++LS Q LVDC     N+GC GG M NAFQY+QK+ G++SE+ Y Y  +E +C Y+ +   A C G+ +I +GNEK L +AVA VGP+SVAIDAS  +FQ Y  G+Y ++SC+S  L+H VLAVGYG +     WI+KNSWG  WG  GYI M ++++N CGIA +AS+P
Sbjct:    4 LKVLLLPVV--------SFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 309.301 bits (791), Expect = 2.292e-103
Identity = 157/324 (48.46%), Postives = 219/324 (67.59%), Query Frame = 1
Query:  148 SAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPI---NKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE-NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++ KL  ++  A+ E+W+ YK  F ++Y    E T    + +N+  I+ HN ++ LG+ ++ +GLN  AD+   +YR K+ G + +   ++    + FLAP N V +P  VDWR    VT VKNQ  CGSCW+FS TG+LEGQH RK GQL+SLSEQ LVDCS  +GN+GCNGGLMD AF+YI+ + G+++EE Y Y  ++  C ++   V A   G+VD  +G+E+ L  AVAT GPIS+AIDA   +FQLYK G+Y ++ CSS +LDHGVL VGYG +  +  +WIVKNSWG  WG  GYI++ ++R+N CG+AT ASYPLV
Sbjct:   17 NSAKLSRQIESAI-EKWDDYKEDFDKEYSESEEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNHIADLPFSQYR-KLNGYRRLFGDSRIKNSSSFLAPFN-VQVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 337          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 243.047 bits (619), Expect = 2.014e-79
Identity = 114/197 (57.87%), Postives = 148/197 (75.13%), Query Frame = 1
Query:  520 CGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE-NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            CGSCW+FS TG+LEGQH RK GQL+SLSEQ LVDCS  +GN+GCNGGLMD AF+YI+ + G+++EE Y Y  ++  C ++   V A   G+VD  +G+E+ L  AVAT GPIS+AIDA   +FQLYK G+Y ++ CSS +LDHGVL VGYG +  +  +WIVKNSWG  WG  GYI++ ++R+N CG+AT ASYPLV
Sbjct:    2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 243.047 bits (619), Expect = 2.014e-79
Identity = 114/197 (57.87%), Postives = 148/197 (75.13%), Query Frame = 1
Query:  520 CGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE-NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            CGSCW+FS TG+LEGQH RK GQL+SLSEQ LVDCS  +GN+GCNGGLMD AF+YI+ + G+++EE Y Y  ++  C ++   V A   G+VD  +G+E+ L  AVAT GPIS+AIDA   +FQLYK G+Y ++ CSS +LDHGVL VGYG +  +  +WIVKNSWG  WG  GYI++ ++R+N CG+AT ASYPLV
Sbjct:    2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: R09F10.1 (pep chromosome:WBcel235:X:8323592:8325046:1 gene:WBGene00019986.1 transcript:R09F10.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R09F10.1)

HSP 1 Score: 194.126 bits (492), Expect = 4.423e-58
Identity = 115/319 (36.05%), Postives = 178/319 (55.80%), Query Frame = 1
Query:  196 WNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGL----NEFADMTNEEYRVKVLGLKPINKN-YTRTIFLAP-------ENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDGLESEEDYSYTA-KEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNE--KSCSSRQLD-HGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            +N + ++F RKY S+ E   R       ++  ++ IE++  +    LGL    NEF D T+EE +      K + +N YT+  F  P       E  V  P S+DWR +G +TP+KNQ  CGSCW+F+T  S+E Q+  K G+L+SLSEQ++VDC     NNGC+GG    A ++++++GLESE++Y Y+A K   C    +        F  +   NE+D+A  V T GP++  ++  K  +  Y+ GI+N   + C+ + +  H +  +GYG E    +WIVKNSWG  WG SGY ++ +   N CG+A     P++
Sbjct:   82 FNDFILKFDRKYTSVEEFEYRY------QIFLRNVIEFE-AEEERNLGLDLDVNEFTDWTDEELQ------KMVQENKYTKYDFDTPKFEGSYLETGVIRPASIDWREQGKLTPIKNQGQCGSCWAFATVASVEAQNAIKKGKLVSLSEQEMVDCDGR--NNGCSGGYRPYAMKFVKENGLESEKEYPYSALKHDQCFLKENDTRVFIDDF-RMLSNNEEDIANWVGTKGPVTFGMNVVKAMYS-YRSGIFNPSVEDCTEKSMGAHALTIIGYGGEGESAYWIVKNSWGTSWGASGYFRLARGV-NSCGLANTVVAPII 382          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597500:1 gene:WBGene00007055.1 transcript:F41E6.6.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196)

HSP 1 Score: 196.438 bits (498), Expect = 5.723e-58
Identity = 118/308 (38.31%), Postives = 182/308 (59.09%), Query Frame = 1
Query:  214 QFQRKYESIIELTRRL-IWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLK------PINK-NYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAF-QYIQKDGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKS--CSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            + ++KY +  E+ +R  ++++N ++I++   + + G   Y  G  +F+DMT  E++  +L  +      P+ + N+ +       N  DLP+S DWR KG VT VKNQ NCGSCW+FSTTG++EG       +L+SLSEQ+LVDC     + GCNGGL  NA+ + I+  GLE E+ Y Y  +   C      +  +  G V++   +E ++ K + T GPIS+ ++A+  T Q Y+ G+ +     C    L+HGVL VGYGK+  + +WIVKNSWGP WG +GY K+ + + N CG+  MA+  LV
Sbjct:  180 RHEKKYTNKREVLKRFRVFKKNAKVIRELQ-KNEQGTAVY--GFTKFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTI--NEEDLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDSM--DQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPH-DEVEMQKWLVTKGPISIGLNAN--TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087592)

HSP 1 Score: 332.028 bits (850), Expect = 4.219e-112
Identity = 161/320 (50.31%), Postives = 227/320 (70.94%), Query Frame = 1
Query:  178 EALNEEWNMYKIQFQRKYESIIELTRRL-IWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLG--------LKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG-KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            + + EEW+ +K++ ++ Y+   E   RL I+ EN   I KHN  +  GK S+ L +N++AD+ + E+R  + G        L+  ++++    F++P + V LPKSVDWRTKG VT VK+Q +CGSCW+FS+TG+LEGQH RK+G L+SLSEQ LVDCS  +GNNGCNGGLMDNAF+YI+ + G+++E+ Y Y A + +C ++   V A   GF DI +G+EK +A+AVATVGP+SVAIDAS  +FQ Y  G+YNE  C ++ LDHGVL VG+G  E+ + +W+VKNSWG  WG  G+IKM +++ NQCGIA+ +SYPLV
Sbjct:   23 DVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAH-VTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087593)

HSP 1 Score: 332.028 bits (850), Expect = 1.071e-111
Identity = 161/320 (50.31%), Postives = 227/320 (70.94%), Query Frame = 1
Query:  178 EALNEEWNMYKIQFQRKYESIIELTRRL-IWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLG--------LKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG-KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            + + EEW+ +K++ ++ Y+   E   RL I+ EN   I KHN  +  GK S+ L +N++AD+ + E+R  + G        L+  ++++    F++P + V LPKSVDWRTKG VT VK+Q +CGSCW+FS+TG+LEGQH RK+G L+SLSEQ LVDCS  +GNNGCNGGLMDNAF+YI+ + G+++E+ Y Y A + +C ++   V A   GF DI +G+EK +A+AVATVGP+SVAIDAS  +FQ Y  G+YNE  C ++ LDHGVL VG+G  E+ + +W+VKNSWG  WG  G+IKM +++ NQCGIA+ +SYPLV
Sbjct:   53 DVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAH-VTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 371          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0339955)

HSP 1 Score: 320.472 bits (820), Expect = 1.253e-107
Identity = 157/309 (50.81%), Postives = 219/309 (70.87%), Query Frame = 1
Query:  211 IQFQRKYESIIELTRRL-IWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLG--------LKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG-KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++ ++ Y+   E   RL I+ EN   I KHN  +  GK S+ L +N++AD+ + E+R  + G        L+  ++++    F++P + V LPKSVDWRTKG VT VK+Q +CGSCW+FS+TG+LEGQH RK+G L+SLSEQ LVDCS  +GNNGCNGGLMDNAF+YI+ + G+++E+ Y Y A + +C ++   V A   GF DI +G+EK +A+AVATVGP+SVAIDAS  +FQ Y  G+YNE  C ++ LDHGVL VG+G  E+ + +W+VKNSWG  WG  G+IKM +++ NQCGIA+ +SYPLV
Sbjct:   31 LEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAH-VTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 338          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0304021)

HSP 1 Score: 292.352 bits (747), Expect = 6.148e-98
Identity = 136/239 (56.90%), Postives = 183/239 (76.57%), Query Frame = 1
Query:  394 LKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG-KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            L+  ++++    F++P + V LPKSVDWRTKG VT VK+Q +CGSCW+FS+TG+LEGQH RK+G L+SLSEQ LVDCS  +GNNGCNGGLMDNAF+YI+ + G+++E+ Y Y A + +C ++   V A   GF DI +G+EK +A+AVATVGP+SVAIDAS  +FQ Y  G+YNE  C ++ LDHGVL VG+G  E+ + +W+VKNSWG  WG  G+IKM +++ NQCGIA+ +SYPLV
Sbjct:   12 LRAADESFKGVTFISPAH-VTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 249          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: CG5367 (gene:FBgn0032228 transcript:FBtr0080055)

HSP 1 Score: 225.713 bits (574), Expect = 1.163e-70
Identity = 119/310 (38.39%), Postives = 189/310 (60.97%), Query Frame = 1
Query:  193 EWNMYKIQFQRKY-ESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPIN----KNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            E+  +K    RKY  +  E+     +EEN ++I++HN  Y  G+ S+ L  N FADM+ + Y    L L   N     +    I  +P    ++P+S+DWR+KG++TP  NQ +CGSC++FS   S+ GQ  ++TG+++SLS+QQ+VDCS   GN GC GG + N   Y+Q   G+  ++DY Y A++G C++     V + T +  +   +E+ +  AV  +GP++++I+AS  TFQLY  GIY++  CSS  ++H ++ +G+GK+    +WI+KN WG  WG +GYI++ K   N CGIA  A+Y +V
Sbjct:   35 EFEKFKNNNNRKYLRTYDEMRSYKAFEENFKVIEEHNQNYKEGQTSFRLKPNIFADMSTDGYLKGFLRLLKSNIEDSADNMAEIVGSPL-MANVPESLDWRSKGFITPPYNQLSCGSCYAFSIAESIMGQVFKRTGKILSLSKQQIVDCSVSHGNQGCVGGSLRNTLSYLQSTGGIMRDQDYPYVARKGKCQFVPDLSVVNVTSWAILPVRDEQAIQAAVTHIGPVAISINASPKTFQLYSDGIYDDPLCSSASVNHAMVVIGFGKD----YWILKNWWGQNWGENGYIRIRKGV-NMCGIANYAAYAIV 338          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-269i1.4 (si:dkey-269i1.4 [Source:ZFIN;Acc:ZDB-GENE-121214-37])

HSP 1 Score: 371.318 bits (952), Expect = 1.556e-127
Identity = 181/340 (53.24%), Postives = 235/340 (69.12%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLK-PINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEG-NCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKEN----NQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            M   LL   C+ ++ A      ++  L++ WN +K Q  + Y   +E+ RR+IWEENLR I++HN EY  G H++ +G+N+F DMTNEE+R  + G K   N+     +F+ P +    P+ VDWR +GYVTPVK+Q  CGSCWSFS+TG+LEGQ  RKTG+LIS+SEQ LVDCS+P GN GCNGGLMD AFQY++++ GL+SE+ Y Y A++   C+YD    VA  TGFVDI KGNE  L  AVA VGP+SVAIDAS  + Q Y+ GIY E++CSS +LDH VL VGYG +        +WIVKNSW  +WG  GYI M KD++N CGIATMASYPL+
Sbjct:    1 MMFALLVTLCISAVFAAS---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRHAMNGYKHDPNQTSQGPLFMEP-SFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 336          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsla (cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106])

HSP 1 Score: 370.548 bits (950), Expect = 2.997e-127
Identity = 181/344 (52.62%), Postives = 237/344 (68.90%), Query Frame = 1
Query:   94 FIITMKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLK-PINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQ-KDGLESEEDYSYTAKEGN-CKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            F+    + L AVF   ++         ++ LN+ W+ +K    +KY +  E  RR+IWE+NL+ I+ HN+E+ +G H+Y LG+N F DMT+EE+R  + G K   ++ +  ++F+ P N +++P  +DWR KGYVTPVK+Q  CGSCW+FSTTG+LEGQ  RKTG+L+SLSEQ LVDCS+P GN GCNGGLMD AFQY++ ++GL+SEE Y Y   +   C +D     A+ TGFVDI  G E+ L KA+A VGP+SVAIDA   +FQ Y+ GIY EK CSS +LDHGVLAVGYG E    + + +WIVKNSW   WG  GYI M KDRHN CGIAT ASYPLV
Sbjct:    4 FLAAFTLCLSAVFAAPTL---------DQQLNDHWDQWKKWHSKKYHATEEGWRRIIWEKNLKKIEMHNLEHSMGIHTYRLGMNHFGDMTHEEFRQVMNGFKHKKDRRFRGSLFMEP-NFIEVPNKLDWREKGYVTPVKDQGECGSCWAFSTTGALEGQMFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDQNGLDSEESYPYLGTDDQPCHFDPKNSAANDTGFVDIPSGKERALMKAIAAVGPVSVAIDAGHESFQFYQSGIYYEKECSSEELDHGVLAVGYGFEGEDVDGKKYWIVKNSWSENWGDKGYIYMAKDRHNHCGIATAASYPLV 337          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsla (cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106])

HSP 1 Score: 370.548 bits (950), Expect = 2.997e-127
Identity = 181/344 (52.62%), Postives = 237/344 (68.90%), Query Frame = 1
Query:   94 FIITMKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLK-PINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQ-KDGLESEEDYSYTAKEGN-CKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            F+    + L AVF   ++         ++ LN+ W+ +K    +KY +  E  RR+IWE+NL+ I+ HN+E+ +G H+Y LG+N F DMT+EE+R  + G K   ++ +  ++F+ P N +++P  +DWR KGYVTPVK+Q  CGSCW+FSTTG+LEGQ  RKTG+L+SLSEQ LVDCS+P GN GCNGGLMD AFQY++ ++GL+SEE Y Y   +   C +D     A+ TGFVDI  G E+ L KA+A VGP+SVAIDA   +FQ Y+ GIY EK CSS +LDHGVLAVGYG E    + + +WIVKNSW   WG  GYI M KDRHN CGIAT ASYPLV
Sbjct:    4 FLAAFTLCLSAVFAAPTL---------DQQLNDHWDQWKKWHSKKYHATEEGWRRIIWEKNLKKIEMHNLEHSMGIHTYRLGMNHFGDMTHEEFRQVMNGFKHKKDRRFRGSLFMEP-NFIEVPNKLDWREKGYVTPVKDQGECGSCWAFSTTGALEGQMFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDQNGLDSEESYPYLGTDDQPCHFDPKNSAANDTGFVDIPSGKERALMKAIAAVGPVSVAIDAGHESFQFYQSGIYYEKECSSEELDHGVLAVGYGFEGEDVDGKKYWIVKNSWSENWGDKGYIYMAKDRHNHCGIATAASYPLV 337          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52])

HSP 1 Score: 367.851 bits (943), Expect = 3.115e-126
Identity = 181/337 (53.71%), Postives = 236/337 (70.03%), Query Frame = 1
Query:  115 VLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLK-PINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEG-NCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKEN----NQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++ A+   + ISA      ++  L++ WN +K Q  + Y   +E+ RR+IWEENLR I++HN EY LG H++ +G+N+F DMTNEE+R  + G K   N+     +F+ P+     P+ VDWR +GYVTPVK+Q  CGSCWSFS+TG+LEGQ  RKTG+LIS+SEQ LVDCS+P GN GCNGGLMD AFQY++++ GL+SE+ Y Y A++   C+YD    VA  TGFVDI KGNE  L  AVA VGP+SVAIDAS  + Q Y+ GIY E++C+S QLDH VL VGYG +        +WIVKNSW  +WG  GYI M KD++N CGIATMASYPL+
Sbjct:    1 MMFALLVTLYISAVFAAPSIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPK-FFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTS-QLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52])

HSP 1 Score: 367.851 bits (943), Expect = 3.115e-126
Identity = 181/337 (53.71%), Postives = 236/337 (70.03%), Query Frame = 1
Query:  115 VLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLK-PINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEG-NCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKEN----NQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++ A+   + ISA      ++  L++ WN +K Q  + Y   +E+ RR+IWEENLR I++HN EY LG H++ +G+N+F DMTNEE+R  + G K   N+     +F+ P+     P+ VDWR +GYVTPVK+Q  CGSCWSFS+TG+LEGQ  RKTG+LIS+SEQ LVDCS+P GN GCNGGLMD AFQY++++ GL+SE+ Y Y A++   C+YD    VA  TGFVDI KGNE  L  AVA VGP+SVAIDAS  + Q Y+ GIY E++C+S QLDH VL VGYG +        +WIVKNSW  +WG  GYI M KD++N CGIATMASYPL+
Sbjct:    1 MMFALLVTLYISAVFAAPSIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPK-FFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTS-QLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 377.096 bits (967), Expect = 9.692e-130
Identity = 187/334 (55.99%), Postives = 237/334 (70.96%), Query Frame = 1
Query:  121 LAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGN-CKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG----KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            +A  C+ ++ A       + AL+  WN++K   ++ Y    E  RR++WE+NLR+I+ HN+E+ LGKHS+ LG+N+F DMTNEE+R  + G K   K    + FLAP N  + PKSVDWR KGYVTPVK+Q  CGSCW+FSTTG+LEGQH R TG++ISLSEQ LVDCS+  GN GCNGGLMD AFQY++ + G++SE+ Y YTAK+   C YD +   A+ TGFVD+  G+EKDL  AVA+VGP+SVA+DA   +FQ YK GIY E  CSS  LDHGVL VGYG     E+ + +WIVKNSW  +WG  GYI + KDRHN CGIAT ASYPLV
Sbjct:    7 IAAICLTTVFAAPT---TDPALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKN-QKKIRGSTFLAP-NNFESPKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 335          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 377.096 bits (967), Expect = 1.483e-129
Identity = 188/343 (54.81%), Postives = 243/343 (70.85%), Query Frame = 1
Query:   94 FIITMKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGN-CKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG----KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            +I+ + + + A+ C+ ++ A       + AL+  WN++K   ++ Y    E  RR++WE+NLR+I+ HN+E+ LGKHS+ LG+N+F DMTNEE+R  + G K   K    + FLAP N  + PKSVDWR KGYVTPVK+Q  CGSCW+FSTTG+LEGQH R TG++ISLSEQ LVDCS+  GN GCNGGLMD AFQY++ + G++SE+ Y YTAK+   C YD +   A+ TGFVD+  G+EKDL  AVA+VGP+SVA+DA   +FQ YK GIY E  CSS  LDHGVL VGYG     E+ + +WIVKNSW  +WG  GYI + KDRHN CGIAT ASYPLV
Sbjct:    6 YIMALYLGIAAI-CLTTVFAAPT---TDPALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKN-QKKIRGSTFLAP-NNFESPKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 342          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: harbi1 (harbinger transposase derived 1 [Source:Xenbase;Acc:XB-GENE-6077433])

HSP 1 Score: 315.464 bits (807), Expect = 1.733e-105
Identity = 155/314 (49.36%), Postives = 211/314 (67.20%), Query Frame = 1
Query:  175 NEALNEEWNMYKIQFQRKYESII-ELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVD--LPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            N  L+ EW ++K  + + Y++ I EL RRLIWE+NL +I+ HN+E+  G H+Y LG+N+F DMT+EE    + GLK ++     T   + E+     +P S+D+R KGYVTP+++Q  CGSCW+FST G+LEGQ  +KTG+L+ +S Q LVDC K   N GC GG M  AF+Y++K+ G++SEE Y Y   +  CKY+ S   A   GF ++KKG+E  L KAV  VGPISV IDA   TF LYK GIY +KSC    ++H VLAVGYGK+    +WI+KNSWG  WG  GYI M +++ N CGIA +ASYP++
Sbjct:   21 NGTLDSEWEIWKTTYHKHYDNKIHELMRRLIWEKNLNIIRSHNLEFTQGLHTYELGMNKFGDMTSEEVVRMMTGLK-VHTGMGPTNLTSDEDEASQRIPNSIDYRKKGYVTPIRDQGECGSCWAFSTVGALEGQLMKKTGKLVGISPQNLVDCVKD--NFGCGGGYMTTAFKYVKKNKGIDSEEAYPYVGMDQKCKYNVSGRAAEIKGFKEVKKGSETALKKAVGLVGPISVGIDAGLDTFFLYKKGIYYDKSCDGDSINHAVLAVGYGKQKKGKYWIIKNSWGEDWGNKGYILMAREKGNACGIANLASYPVM 331          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ano1 (anoctamin 1, calcium activated chloride channel [Source:Xenbase;Acc:XB-GENE-5967576])

HSP 1 Score: 311.227 bits (796), Expect = 8.867e-104
Identity = 146/332 (43.98%), Postives = 218/332 (65.66%), Query Frame = 1
Query:  124 AVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIE-LTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTV---DLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQY-IQKDGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++  + ++ A  +K  +N AL+  W ++K    + YE  IE L RR+ WE+NL L+  HN+EY +G H+Y LG+N  ADMT+EE + K+ GL    ++  +  F + +N+     +P S+DWR KG V+ VKNQ  CGSCW+FS  G+LEGQ   KTG+L+SLS Q LVDCS  +GN GC GG M  AFQY I   G++S+  Y Y A +  C YD +   + C  + +I  G E +L +A+ ++GPISVAID ++P+F LY+ G+Y++ +C S +++HGVLAVGYG  N Q FW++KNSWG ++G  GY+++ +++ N CG+A+   YP +
Sbjct:    3 SLIFLATVLAAIVKARINPALDNHWLLWKNTHNKDYEDEIEDLQRRITWEKNLNLVNMHNLEYSMGMHTYELGMNHLADMTSEEIKSKLTGLILPPQSERQATFSSQKNSTFGGKVPDSIDWRDKGCVSDVKNQGGCGSCWAFSAVGALEGQLMLKTGKLVSLSPQNLVDCSSKYGNKGCGGGFMTQAFQYVIDNKGIDSDSYYPYHAMDEKCHYDPTGKASTCAKYTEIVPGTEDNLKQALGSIGPISVAIDGTRPSFFLYRSGVYSDPTC-SHEVNHGVLAVGYGNLNGQDFWLLKNSWGTKYGDQGYVRIARNKGNLCGVASYTCYPEI 333          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: mdk (midkine [Source:Xenbase;Acc:XB-GENE-488502])

HSP 1 Score: 306.22 bits (783), Expect = 8.871e-102
Identity = 148/346 (42.77%), Postives = 229/346 (66.18%), Query Frame = 1
Query:   85 FVKFIITMKIVLLAVFCVVSISAGKLKFEV--NEALNEEWNMYKIQFQRKYES-IIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVD--LPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            F++  +   + ++  FC++++    ++  +  +E L+ EW+++K  + ++Y   + E  RRLIWE+N ++I  HN+EY  G H+Y + +N   DMT+EE    + GL    +N + T F + +NT    +P S+D+R KGYVTP++NQ +CGSCW+FS+ G+LEGQ K+K G+L+ LS Q LVDC K   N+GC GG M NAF+Y++ + G++SE  Y Y  ++  C Y+A+   A C GF ++++G+EK L KAV  VGP+SV IDA   +FQ Y  G+Y +K C++  ++H VLAVGYG +    +WIVKNSWG  WG  GYI M +++ N CGI+++ASYP++
Sbjct:    3 FIRRFLPFYLGIMLSFCLLALVLPLVRTNLFGDETLDAEWDLWKRTYHKQYNGQMDEGLRRLIWEKNFKMITAHNLEYSEGLHTYEMAMNHLGDMTSEEVVRTMTGLWVHRRNRS-TNFTSEDNTAQEKIPDSIDYRKKGYVTPIRNQGSCGSCWAFSSVGALEGQLKKKKGKLVDLSPQNLVDCVKK--NDGCGGGYMTNAFEYVRDNKGIDSENAYPYVGEDQECMYNATGKAASCKGFKEVQEGSEKALKKAVGLVGPVSVGIDAGLSSFQFYSKGVYYDKDCNAENINHAVLAVGYGTQKKTKYWIVKNSWGEDWGNKGYILMAREKDNACGISSLASYPVM 345          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 353.984 bits (907), Expect = 1.134e-120
Identity = 181/317 (57.10%), Postives = 224/317 (70.66%), Query Frame = 1
Query:  169 EVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            + ++  + EW+ +K   +R Y +  E  RR IWE+N+R+IQ HN EY  G+H + + +N F DMTNEE+R  V G +   K+    +F  P   + +PKSVDWR KG VTPVKNQ  CGSCW+FS +G LEGQ   KTG+LISLSEQ LVDCS   GN GCNGGLMD AFQYI+++ GL+SEE Y Y AK+G+CKY A   VA+ TGFVDI +  EK L KAVATVGPISVA+DAS P+ Q Y  GIY E +CSS+ LDHGVL VGYG E    N   +W+VKNSWG +WG+ GYIK+ KDR N CG+AT ASYP+V
Sbjct:   20 KFDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRH-QKHKKGRLFQEPL-MLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 353.984 bits (907), Expect = 1.134e-120
Identity = 181/317 (57.10%), Postives = 224/317 (70.66%), Query Frame = 1
Query:  169 EVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            + ++  + EW+ +K   +R Y +  E  RR IWE+N+R+IQ HN EY  G+H + + +N F DMTNEE+R  V G +   K+    +F  P   + +PKSVDWR KG VTPVKNQ  CGSCW+FS +G LEGQ   KTG+LISLSEQ LVDCS   GN GCNGGLMD AFQYI+++ GL+SEE Y Y AK+G+CKY A   VA+ TGFVDI +  EK L KAVATVGPISVA+DAS P+ Q Y  GIY E +CSS+ LDHGVL VGYG E    N   +W+VKNSWG +WG+ GYIK+ KDR N CG+AT ASYP+V
Sbjct:   20 KFDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRH-QKHKKGRLFQEPL-MLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: BC051665 (cDNA sequence BC051665 [Source:MGI Symbol;Acc:MGI:2682300])

HSP 1 Score: 323.939 bits (829), Expect = 6.417e-109
Identity = 164/333 (49.25%), Postives = 218/333 (65.47%), Query Frame = 1
Query:  112 IVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENN-QHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            + LLA  C+  +SA        +A+ EEW   K + ++ Y    E  +R +WE N+++I  HN +Y  GKH + L +N F D+TN E+R  + G + +      TIF  P    D+PKSVDWR  GYVTPVK+Q +CGSCW+FS  GSLEGQ  RKTG+L+ LSEQ L+DCS  +GN GCNGGLM+ AFQY++++ GL++ E Y+Y A +G C+YD      + TGFV +   +E  L  AVA+VGP+SV ID    +F+ Y+GG Y E  CSS  LDH VL VGYG+E++ + +W+VKNSWG  WG+ GYIKM KDR N CGIAT A YP V
Sbjct:    4 VFLLATLCLGVVSAAPAHDPSLDAVWEEW---KTKHRKTYNMNEEAQKRAVWENNMKMIGLHNEDYLKGKHGFNLEMNAFGDLTNTEFRELMTGFQSMGHK-EMTIFQEPL-LGDVPKSVDWRDHGYVTPVKDQGHCGSCWAFSAVGSLEGQIFRKTGKLVPLSEQNLMDCSWSYGNVGCNGGLMELAFQYVKENRGLDTRESYAYEAWDGPCRYDPKYSAVNITGFVKVPL-SEDALMNAVASVGPVSVGIDTHHHSFRFYRGGTYYEPDCSSTNLDHAVLVVGYGEESDGRKYWLVKNSWGEDWGMDGYIKMAKDRDNNCGIATYAIYPTV 330          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsll3 (cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917452])

HSP 1 Score: 321.242 bits (822), Expect = 7.582e-108
Identity = 163/333 (48.95%), Postives = 215/333 (64.56%), Query Frame = 1
Query:  112 IVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENN-QHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            + LLA  C+  +SA       N +L+  W  +K + ++ Y    E  +R +WE N ++I  HN +Y  GKH + L +N F D+TN E+R  + G +         +F  P    D+PKSVDWR  GYVTPVK+Q +CGSCW+FS  GSLEGQ  RKTG+L+ LS Q LVDCS   GN GC+GGL D AFQY++ + GL++   Y Y A  G C+Y+     A  TGFV+++  +E  L KAVATVGPISV ID    +FQ YK G+Y E  CSS  LDH VL VGYG+E++ + +W+VKNSWG  WG++GYIKM KDR+N CGIA+ ASYP+V
Sbjct:    4 VFLLATLCLGVVSAAPAH---NPSLDAVWEEWKTKHKKTYNMNDEGQKRAVWENNKKMIDLHNEDYLKGKHGFSLEMNAFGDLTNTEFRELMTGFQGQKTKMMMKVFQEPL-LGDVPKSVDWRDHGYVTPVKDQGSCGSCWAFSAVGSLEGQMFRKTGKLVPLSVQNLVDCSWSQGNQGCDGGLPDLAFQYVKDNGGLDTSVSYPYEALNGTCRYNPKNSAATVTGFVNVQS-SEDALMKAVATVGPISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYGEESDGRKYWLVKNSWGRDWGMNGYIKMAKDRNNNCGIASDASYPVV 331          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsk (cathepsin K [Source:MGI Symbol;Acc:MGI:107823])

HSP 1 Score: 315.464 bits (807), Expect = 1.270e-105
Identity = 151/327 (46.18%), Postives = 214/327 (65.44%), Query Frame = 1
Query:  127 VFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESII-ELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLK-PINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDG-LESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYP 1098
            VF  + +          E L+ +W ++K   Q++Y S + E++RRLIWE+NL+ I  HN+E  LG H+Y L +N   DMT+EE   K+ GL+ P +++Y+      PE    +P S+D+R KGYVTPVKNQ  CGSCW+FS+ G+LEGQ K+KTG+L++LS Q LVDC     N GC GG M  AFQY+Q++G ++SE+ Y Y  ++ +C Y+A+   A C G+ +I  GNEK L +AVA VGPISV+IDAS  +FQ Y  G+Y +++C    ++H VL VGYG +     WI+KNSWG  WG  GY  + ++++N CGI  MAS+P
Sbjct:    3 VFKFLLLPMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTE--NYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFP 327          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|O60911|CATL2_HUMAN (Cathepsin L2 OS=Homo sapiens OX=9606 GN=CTSV PE=1 SV=2)

HSP 1 Score: 363.614 bits (932), Expect = 1.256e-123
Identity = 184/335 (54.93%), Postives = 234/335 (69.85%), Query Frame = 1
Query:  115 VLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++LA FC+  I++   KF+ N  L+ +W  +K   +R Y +  E  RR +WE+N+++I+ HN EY  GKH + + +N F DMTNEE+R +++G     K     +F  P   +DLPKSVDWR KGYVTPVKNQ  CGSCW+FS TG+LEGQ  RKTG+L+SLSEQ LVDCS+P GN GCNGG M  AFQY++++ GL+SEE Y Y A +  CKY     VA+ TGF  +  G EK L KAVATVGPISVA+DA   +FQ YK GIY E  CSS+ LDHGVL VGYG E    NN  +W+VKNSWGP+WG +GY+K+ KD++N CGIAT ASYP V
Sbjct:    5 LVLAAFCL-GIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPL-FLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P07711|CATL1_HUMAN (Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2)

HSP 1 Score: 360.147 bits (923), Expect = 2.832e-122
Identity = 184/335 (54.93%), Postives = 228/335 (68.06%), Query Frame = 1
Query:  115 VLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++LA FC+  I++  L F+   +L  +W  +K    R Y    E  RR +WE+N+++I+ HN EY  GKHS+ + +N F DMT+EE+R  + G +  N+   +          + P+SVDWR KGYVTPVKNQ  CGSCW+FS TG+LEGQ  RKTG+LISLSEQ LVDCS P GN GCNGGLMD AFQY+Q + GL+SEE Y Y A E +CKY+    VA+ TGFVDI K  EK L KAVATVGPISVAIDA   +F  YK GIY E  CSS  +DHGVL VGYG E    +N  +W+VKNSWG +WG+ GY+KM KDR N CGIA+ ASYP V
Sbjct:    5 LILAAFCL-GIASATLTFD--HSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQ--NRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GKL8|CATL1_CHLAE (Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CTSL PE=1 SV=1)

HSP 1 Score: 358.221 bits (918), Expect = 1.247e-121
Identity = 183/334 (54.79%), Postives = 225/334 (67.37%), Query Frame = 1
Query:  118 LLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            +LA  C+  I++  L F  N +L  +W  +K    R Y    E  RR +WE+N+++I+ HN EY  GKHS+ + +N F DMT+EE+R  + G +  N+   +          + P+SVDWR KGYVTPVKNQ  CGSCW+FS TG+LEGQ  RKTG+L+SLSEQ LVDCS P GN GCNGGLMD AFQY+  + GL+SEE Y Y A E +CKY+    VA+ TGFVDI K  EK L KAVATVGPISVAIDA   +F  YK GIY E  CSS  +DHGVL VGYG E    +N  +W+VKNSWG +WG+ GYIKM KDR N CGIA+ ASYP V
Sbjct:    6 ILAALCL-GIASATLTF--NHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHSFTMAMNTFGDMTSEEFRQVMNGFQ--NRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVADNGGLDSEESYPYEATEESCKYNPEYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFMFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNSKYWLVKNSWGEEWGMGGYIKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q5E998|CATL2_BOVIN (Cathepsin L2 OS=Bos taurus OX=9913 GN=CTSV PE=2 SV=1)

HSP 1 Score: 357.451 bits (916), Expect = 2.766e-121
Identity = 185/335 (55.22%), Postives = 226/335 (67.46%), Query Frame = 1
Query:  118 LLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDG-LESEEDYSYTAKEGN-CKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
             L V C+   SA     +++  L+  W+ +K   +R Y    E  RR +WE+N ++I  HN EY  GKH + + +N F DMTNEE+R  + G +  N+ + +         VD+PKSVDW  KGYVTPVKNQ  CGSCW+FS TG+LEGQ  RKTG+L+SLSEQ LVDCS+  GN GCNGGLMDNAFQYI+ +G L+SEE Y Y A + N C Y      A+ TGFVDI +  EK L KAVATVGPISVAIDA   +FQ YK GIY +  CSS+ LDHGVL VGYG E    NN  FWIVKNSWGP+WG +GY+KM KD++N CGIAT ASYP V
Sbjct:    6 FLTVLCLGVASAAP---KLDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHGFRMAMNAFGDMTNEEFRQVMNGFQ--NQKHKKGKLFHEPLLVDVPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGCLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P25975|CATL1_BOVIN (Cathepsin L1 OS=Bos taurus OX=9913 GN=CTSL PE=1 SV=3)

HSP 1 Score: 357.451 bits (916), Expect = 2.858e-121
Identity = 185/335 (55.22%), Postives = 226/335 (67.46%), Query Frame = 1
Query:  118 LLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGN-CKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
             L V C+   SA     +++  L+  W+ +K   +R Y    E  RR +WE+N ++I  HN EY  GKH + + +N F DMTNEE+R  + G +  N+ + +         VD+PKSVDW  KGYVTPVKNQ  CGSCW+FS TG+LEGQ  RKTG+L+SLSEQ LVDCS+  GN GCNGGLMDNAFQYI+ + GL+SEE Y Y A + N C Y      A+ TGFVDI +  EK L KAVATVGPISVAIDA   +FQ YK GIY +  CSS+ LDHGVL VGYG E    NN  FWIVKNSWGP+WG +GY+KM KD++N CGIAT ASYP V
Sbjct:    6 FLTVLCLGVASAAP---KLDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHGFRMAMNAFGDMTNEEFRQVMNGFQ--NQKHKKGKLFHEPLLVDVPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A2U8U447 (Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1)

HSP 1 Score: 499.975 bits (1286), Expect = 4.946e-175
Identity = 226/333 (67.87%), Postives = 273/333 (81.98%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            MKI+LL    +V+I A   KF +N  LN+EW +YK++F +KYE++ E++RR+IWE NL+ IQ+HN+EYDLGKH+YYLGLNEFADMT+EE++ K LGLKPIN+N+T + F+ PEN  DLP  +DWRTKGYVTPVKNQ  CGSCW+FSTTGSLEGQH RK+G+L+S SEQQLVDCS+ F N GCNGGLMDNAF YIQK G+E+E  Y Y A +G C YD +K+V  CTGFVDIK GNE DL  AVAT GPISVAIDAS  +FQ Y+GGIYNE  CSS+ LDHGVLA+GYG ENN+++WIVKNSW   WG+SGYI+M+KD+ NQCGIATMASYPLV
Sbjct:    1 MKIILLTSIFLVTIQAVPHKFTINSELNDEWEVYKMKFSKKYETLNEISRRIIWENNLKFIQQHNVEYDLGKHTYYLGLNEFADMTHEEFKAKYLGLKPINRNFTSSRFIIPENIGDLPTRIDWRTKGYVTPVKNQGQCGSCWAFSTTGSLEGQHFRKSGKLVSFSEQQLVDCSRSFDNLGCNGGLMDNAFSYIQKFGIENEISYPYVANDGVCAYDKTKIVGTCTGFVDIKTGNETDLMAAVATQGPISVAIDASNDSFQFYRGGIYNEPHCSSKDLDHGVLAIGYGSENNENYWIVKNSWDISWGMSGYIRMSKDKMNQCGIATMASYPLV 333          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A087UR18 (Cathepsin L (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_15117 PE=3 SV=1)

HSP 1 Score: 394.815 bits (1013), Expect = 9.741e-133
Identity = 187/332 (56.33%), Postives = 247/332 (74.40%), Query Frame = 1
Query:  112 IVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDG-LESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
              LLA+  + +++A  +    +  L+  WN +K  FQ++Y    E  RRLI+E+++  I KHN+E+DLG H Y  GLNEFADMT+EE+   + G K    N + + F+ P N +D P +VDWR  G VT VKNQ  CGSCW+FSTTGSLEGQHK+KTG+L+SLSEQ LVDCS+P GN+GC GGLMD  F YI+++G +++EE Y YTA++G C +  S + A C+G+VDI KG+EK L KAVAT+GPISVAIDAS+ +FQLY GGIY+E +CS+ +LDHGVLAVGYG E+   +W+VKNSWG  WG +GYIKM+++++NQCGIAT ASYPLV
Sbjct:   57 FALLAIVVLHTVNAATV---FDPDLDIHWNSFKRTFQKQYTVFEEGARRLIFEDHVNDIVKHNLEFDLGIHKYRKGLNEFADMTHEEFVKTLNGFKGAKLNKSASTFVPPSN-IDFPDTVDWRQHGLVTGVKNQGQCGSCWAFSTTGSLEGQHKKKTGKLVSLSEQNLVDCSRPEGNSGCEGGLMDQGFDYIKENGGIDTEESYPYTAEDGTCHFKKSSIGATCSGYVDIPKGDEKALQKAVATIGPISVAIDASQFSFQLYSGGIYDEPNCSTEELDHGVLAVGYGTEDGTDYWLVKNSWGTSWGENGYIKMSRNKNNQCGIATQASYPLV 384          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A267H1I6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013052g1 PE=3 SV=1)

HSP 1 Score: 389.808 bits (1000), Expect = 1.532e-131
Identity = 188/334 (56.29%), Postives = 236/334 (70.66%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            MK   L   C+V+ +    +F +   LNEEW  YK    + YE+  EL RRLIWE+NL+ IQKHN+EYD G HSY LG+N+F D+T  E++ K L   P  +    ++FL   N   LP  VDWRTKGYVT VK+Q  CGSCW+FSTTGSLEGQH +KTG L+SLSEQ LVDCS  FGN GCNGGLMDN F+YI+ + G+++E  Y Y A++  C + +S V A  +GFVDI   NE  L +AVAT+GPISVAIDA   +FQLYK G+Y+E+ CS  QLDHGVLAVGYG E  + +W+VKNSWG  WG+ GYI M++++ NQCGIA+ ASYPLV
Sbjct:    1 MKAAALIALCLVAAATAYPQFTLE--LNEEWEAYKSTHGKVYEADEELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYLSPMPAAEP-EGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQQAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A1I8GVB7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 389.037 bits (998), Expect = 2.702e-131
Identity = 188/334 (56.29%), Postives = 235/334 (70.36%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            MK   L   C+V+ +    +F +   LNEEW  YK    + YE+  EL RRLIWE+NL+ IQKHN+EYD G HSY LG+N+F D+T  E++ K L   P  +    ++FL   N   LP  VDWRTKGYVT VK+Q  CGSCW+FSTTGSLEGQH +KTG L+SLSEQ LVDCS  FGN GCNGGLMDN F+YI+ + G+++E  Y Y A++  C + +S V A  +GFVDI   NE  L  AVAT+GPISVAIDA   +FQLYK G+Y+E+ CS  QLDHGVLAVGYG E  + +W+VKNSWG  WG+ GYI M++++ NQCGIA+ ASYPLV
Sbjct:    1 MKAAALIALCLVAAATAYPQFTLE--LNEEWEAYKSTHGKVYEADEELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYLSPMPAAEP-EGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQHAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A087UR19 (Cathepsin L (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_15118 PE=3 SV=1)

HSP 1 Score: 389.423 bits (999), Expect = 3.014e-131
Identity = 182/336 (54.17%), Postives = 243/336 (72.32%), Query Frame = 1
Query:  100 ITMKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDG-LESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            + + +   A+  +V +         +  L+  W  +K  FQ++Y    E  RRLI+E ++  I KHN+E+DLG H Y  GLNEFADMT+EE+   + G K    N + T F+ P N +DLP +VDWR +G VT +KNQ  CGSCW+FSTTGSLEGQHK+KTG+L+SLSEQ L+DCS+P GN GC GGLMD  F+YI+K+G +++E+ Y YTA++G C +  + V A CTGFVDI  G+E  L KAVAT+GP+SVAIDAS+ +FQLY GGIY+E +CS++ LDHGVLA+GYG E+   +W+VKNSWG  WG +GYIKM+++++NQCGIAT ASYPLV
Sbjct:    3 MAVPVTYFAILAIVVLQGVNAATIFDPELDTHWENFKRIFQKQYSGREEGARRLIFEGHVNDIVKHNLEFDLGIHKYRKGLNEFADMTHEEFVKTLNGFKGAKLNKSTTTFVPPSN-IDLPDTVDWRQQGLVTGIKNQGQCGSCWAFSTTGSLEGQHKKKTGKLVSLSEQNLMDCSRPEGNMGCEGGLMDQGFEYIKKNGGIDTEKSYPYTAEDGTCHFKKANVGATCTGFVDIPSGDESALQKAVATIGPVSVAIDASQFSFQLYSGGIYDEPNCSTQALDHGVLAIGYGTEDGTDYWLVKNSWGTSWGENGYIKMSRNKNNQCGIATQASYPLV 337          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: si:dkey-26g8.5 (cathepsin L1-like [Source:NCBI gene;Acc:103028700])

HSP 1 Score: 373.629 bits (958), Expect = 1.594e-128
Identity = 183/344 (53.20%), Postives = 243/344 (70.64%), Query Frame = 1
Query:   94 FIITMKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKP-INKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGN-CKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG----KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
              +T+  +L   FC      G     ++  L++ W ++K    + Y    E  RRL+WE+NL+ ++ HN+E+ +GKH+Y LG+N+FADMTNEE+R  + G +   NK    ++FL P + +++PK VDWR KGYVTPVK+QA CGSCW+FS+TG+LEGQH RKTG+L+SLSEQ LVDCS+P GN GCNGG+M+ AFQY++ + G++SEE Y YTAK+   C+YD +   A+ TGFVDI  G E  L KAVA VGP+SVAIDA   +FQ Y+ GIY EK+CSS +LDHGVL VGYG     E+ + +WIVKNSW  +WG +GYI M KDR N CGIA+ ASYPL+
Sbjct:    1 MFLTLASLLALCFCT-----GFTAPSLDRQLDDHWKLWKSWHSKSYHEKEEGWRRLVWEKNLKKVELHNLEHSMGKHTYRLGMNQFADMTNEEFRQAMNGYRSNPNKKSKGSLFLEP-SFLEVPKQVDWREKGYVTPVKDQARCGSCWAFSSTGALEGQHFRKTGKLVSLSEQNLVDCSRPEGNQGCNGGIMEQAFQYVKDNGGIDSEESYPYTAKDDQPCRYDPNFNSANDTGFVDIPSGEEHALMKAVAAVGPVSVAIDAGHESFQFYQSGIYYEKACSSEELDHGVLVVGYGFEGADEDGKKYWIVKNSWSEKWGQNGYIYMAKDRKNHCGIASAASYPLM 338          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsl.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023607])

HSP 1 Score: 351.673 bits (901), Expect = 5.369e-120
Identity = 172/309 (55.66%), Postives = 222/309 (71.84%), Query Frame = 1
Query:  193 EWNMYKIQFQRKYESIIELT-RRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYR---VKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            E++ +K++F + Y S+ E + R+L W  N +L+  HN+  D G  SY LG+  FADM N+EYR      LG     K ++ T FL       LP +VDWR KGYVT +K+Q +CGSCW+FS TGSLEGQ  RKTG+L+SLSEQQLVDCS  +GN GC GGLMD AF+YI+ + G+++E+ Y Y A +G+C++    V A CTGFVDI  G+EK L +AVAT+GPISVAIDA   +FQLY+ GIYNE  CSS +LDHGVLAVGYG +N + +W+VKNSWG  WG  GYI+M+++  NQCGIATM+SYPLV
Sbjct:   25 EFHAWKLKFGKIYHSVEEESQRKLTWLTNRKLVLVHNMLADQGIKSYRLGMTFFADMDNKEYRKLFASCLGSFNRTKAHSATTFLRQTLRDPLPDTVDWRPKGYVTDIKDQKDCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNFGCGGGLMDQAFEYIKANKGIDTEDSYPYEAVDGDCRFKPDSVGATCTGFVDITSGDEKALQEAVATIGPISVAIDAGHSSFQLYESGIYNEPDCSSTELDHGVLAVGYGTDNGKDYWLVKNSWGLDWGNKGYIQMSRNEDNQCGIATMSSYPLV 333          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsla (cathepsin L1-like [Source:NCBI gene;Acc:103043056])

HSP 1 Score: 340.502 bits (872), Expect = 1.520e-115
Identity = 180/343 (52.48%), Postives = 222/343 (64.72%), Query Frame = 1
Query:  106 MKIVLLAV-FCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQ-KDGLESEEDYSYTAKEGN-CKY---DASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKEN----NQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            M +   AV F  V  ++G     ++  L+  W  +K    +KY+   E  RR IWE N + I  HNI   LG   Y LG+N F DMTNEE++    G K IN+   R++F+ P+     P  VDWR KGYVTPVK+Q +CGSCW+FSTTG+LEGQ  +KTG+L+SLSEQ LVDCS+P GN GCNGGLM+ AFQYIQ + GL SE  Y Y   +   C Y   D S V+ +  GFVDI  G E DL K VA +GP+SVAIDA   +FQ Y+ GIYNEK CSS +L+HGVL VGYG +      + +WIVKNSWG  WG  GYI M KD+ NQCGIAT ASYPL+
Sbjct:    1 MHLAFFAVCFSTVFAASG-----LDHDLDNNWEQFKKINSKKYQEKEEGWRRGIWENNFKKIVMHNINNSLGIVPYRLGMNRFGDMTNEEFKQIRNGFKQINEKVRRSVFIVPDFPA-APAQVDWREKGYVTPVKDQGDCGSCWAFSTTGALEGQQFKKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMNLAFQYIQNRGGLNSEGSYPYLGTDDQPCNYNPNDNSAVINN--GFVDISSGTENDLMKTVAAIGPVSVAIDAGHESFQFYQSGIYNEKDCSSDELNHGVLVVGYGFQGEDVEGKRYWIVKNSWGKDWGDDGYIYMAKDQQNQCGIATAASYPLI 335          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000042132.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924])

HSP 1 Score: 332.028 bits (850), Expect = 3.406e-112
Identity = 165/337 (48.96%), Postives = 221/337 (65.58%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLG-LKPIN--KNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDG-LESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            M++ L     V  + A  +  E     + E++ +K++  + Y    E  R++ W  N +L+  HN+  D G  +Y LG+  FADM N+EYR  + G L   N  K    + FL       LP +VDWRT+GYVT VKNQ  CGSCW+FS TG+LEGQ  RK G L+ LSEQQLVDCS+ +GN GC+GG M+ AFQY++ +G L++E+ Y Y A EG C+Y    V A C+G+VDI  G+E+ L +AVATVGP+SVAID    +FQLY+ G+Y+E  CS+  L H VLAVGYG +  Q +W+VKNSWG  WG  GYIKM+++++NQCGIAT ASYPLV
Sbjct:    1 MRVFLAVATLVAVVGAASISME-----DLEFHAWKLKLGKVYNPAEESQRKITWLANRKLVLVHNMLADQGLKTYRLGMTHFADMDNQEYRQMLQGCLGSFNETKAPGASSFLRQAGGATLPNTVDWRTQGYVTEVKNQEMCGSCWAFSATGALEGQMFRKLGYLLPLSEQQLVDCSREYGNMGCSGGWMNQAFQYVKDNGGLDTEDSYPYEAMEGYCRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYGSDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYPLV 332          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000048039.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924])

HSP 1 Score: 332.028 bits (850), Expect = 3.406e-112
Identity = 165/337 (48.96%), Postives = 221/337 (65.58%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLG-LKPIN--KNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDG-LESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            M++ L     V  + A  +  E     + E++ +K++  + Y    E  R++ W  N +L+  HN+  D G  +Y LG+  FADM N+EYR  + G L   N  K    + FL       LP +VDWRT+GYVT VKNQ  CGSCW+FS TG+LEGQ  RK G L+ LSEQQLVDCS+ +GN GC+GG M+ AFQY++ +G L++E+ Y Y A EG C+Y    V A C+G+VDI  G+E+ L +AVATVGP+SVAID    +FQLY+ G+Y+E  CS+  L H VLAVGYG +  Q +W+VKNSWG  WG  GYIKM+++++NQCGIAT ASYPLV
Sbjct:    1 MRVFLAVATLVAVVGAASISME-----DLEFHAWKLKLGKVYNPAEESQRKITWLANRKLVLVHNMLADQGLKTYRLGMTHFADMDNQEYRQMLQGCLGSFNETKAPGASSFLRQAGGATLPNTVDWRTQGYVTEVKNQEMCGSCWAFSATGALEGQMFRKLGYLLPLSEQQLVDCSREYGNMGCSGGWMNQAFQYVKDNGGLDTEDSYPYEAMEGYCRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYGSDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYPLV 332          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006499.1 (pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 gene:ENSPMAG00000005817.1 transcript:ENSPMAT00000006499.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 354.755 bits (909), Expect = 8.754e-122
Identity = 178/341 (52.20%), Postives = 233/341 (68.33%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPI--NKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGN-CKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG----KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            M ++   V  ++++ A       +  L+EEW  +K   Q+ YE   E  RR+IWE+NL  I+ HN+E+ LGKH++ +G+N F DMTNEE+R K+ G   +  +K    + FL P+N  + P +VDWR KG VT VK+Q  CGSCW+FSTTG+LEGQH RK GQL+SLSEQ LVDCS+  GN GC GGLMD AFQY++ + G++SE  Y YT  +G+ C YD     A+ TGFVD+  G+EK L  AVA+VGP+SVAIDAS  +FQ Y+ G+Y E  CSS+ LDHGVL VGYG     EN + +WIVKNSW P+WG  GY+ M +++ N CGIAT ASYPLV
Sbjct:    1 MNVLWSLVPALLAVMASATPIH-DPMLDEEWGSWKGFHQKLYEPKQESWRRMIWEKNLNKIKIHNLEHSLGKHTWRMGMNHFGDMTNEEFRQKMNGYHGVQPHKVSKGSTFLVPQN-YEAPPTVDWRDKGLVTEVKDQGECGSCWAFSTTGALEGQHMRKVGQLVSLSEQNLVDCSRAEGNQGCGGGLMDQAFQYVKDNGGIDSEAAYPYTGTDGDKCHYDPKFNSANDTGFVDVTSGDEKALKIAVASVGPVSVAIDASHESFQFYQSGVYFEPDCSSQDLDHGVLVVGYGVKGTGENGKKYWIVKNSWSPKWGDEGYVLMARNKKNHCGIATAASYPLV 339          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011285.1 (pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gene:ENSPMAG00000010258.1 transcript:ENSPMAT00000011285.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 348.977 bits (894), Expect = 3.960e-120
Identity = 173/299 (57.86%), Postives = 217/299 (72.58%), Query Frame = 1
Query:  223 RKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPIN---KNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQH-FWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            + Y+   E  RR+IWE+NL+ I  HN+E+ +GKH++ +G+N F DMT EE++  +LGL+  N   K      F+AP      P+SVDWR +GYVT VK+Q +CGSCW+FSTTGSLEGQHKRKTG L+SLSEQ LVDCS   GNNGC GGLMD AF YI+K+ G++SE  Y YTAK+ NCKY+     A  TGFVDI  GNE+ L  AVA+VGP+S+ IDAS  +FQLY  GIY++  CS+  LDHGVL VGYG ++++  FWIVKNSWG +WG  GYI M +D+ N CGIAT ASYPLV
Sbjct:    1 KTYDQNEEGWRRMIWEKNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTKEEFQHTMLGLRGSNDTSKASRGATFMAPA-FFKAPESVDWRKQGYVTDVKDQGDCGSCWAFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSAEGNNGCKGGLMDLAFTYIKKNGGIDSEASYPYTAKDENCKYNPKNKAAEDTGFVDIPSGNEEALKNAVASVGPVSIGIDASLESFQLYSSGIYSDSDCSN-NLDHGVLVVGYGVDDDERKFWIVKNSWGTKWGDHGYILMARDKDNLCGIATAASYPLV 297          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010475.1 (pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 gene:ENSPMAG00000009483.1 transcript:ENSPMAT00000010475.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 337.806 bits (865), Expect = 8.350e-116
Identity = 165/289 (57.09%), Postives = 210/289 (72.66%), Query Frame = 1
Query:  253 RRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPIN---KNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG-KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            RR+IWE+NL+ I  HN+E+ +GKH++ +G+N+F+DMT EE++  +LG +  N   K      F+AP    + P+SVDWR +GYVT +KNQ +CGSCWSFSTTGSLEGQHKRKTG L+SLSEQ LVDCS   GN+GCNGGLM NAF YI+K+ G++SEE Y Y  +   CKYD     A  TG+V+I +G+E+ L  AVA+VGP+SVAIDAS  +FQ Y  GIY +  C S  +DH VL VGYG  E  Q FW+VKNSWG  WG  GY++M +D +N CGIATM+SYPLV
Sbjct:    7 RRIIWEKNLKRISVHNLEHSMGKHTWRMGMNQFSDMTGEEFQQVMLGFRGWNGTSKAPRGATFMAPA-FFEAPESVDWRKQGYVTDIKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNHGCNGGLMINAFNYIKKNGGIDSEESYPYKGQVETCKYDPKNKAAEVTGYVEIPEGDEEALMNAVASVGPVSVAIDASLASFQSYGSGIYKDAMC-SHHIDHAVLVVGYGVDEMGQKFWLVKNSWGVTWGEQGYVRMARDDNNLCGIATMSSYPLV 293          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008535.1 (pep scaffold:Pmarinus_7.0:GL478103:36116:54424:1 gene:ENSPMAG00000007699.1 transcript:ENSPMAT00000008535.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 326.25 bits (835), Expect = 1.949e-110
Identity = 160/331 (48.34%), Postives = 225/331 (67.98%), Query Frame = 1
Query:  118 LLAVF-CVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKV----LGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYI-QKDGLESEEDYSYTAKE-GNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG----KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGI 1077
            + AVF C+V++         + AL+  W  + + F++ Y     + RRLIWEEN+R + +HN+E+ LG HSY LG+N  AD+T +E+R  +     G +  ++ +  + FLAPEN  ++P+S+DWR +G VTP+KNQ  CGSCW+FS+TG+LEGQ KR++G+L+ LSEQ L+DCS+P G  GC GG MD+AFQY+  + G++SE DY YTA +  +C YD S++VA  +GFVDI KG+EKDL  AVA+VGP+SVAIDA   +FQLY+ GIY E  C+  +LDH VL VG+G     EN + FWIVKN  G Q G   Y+++  D+   CG+
Sbjct:    9 VAAVFACLVALVGALAVSRPDPALDGHWEAWTVYFKKAYTQTDGIKRRLIWEENMRFVDRHNLEHSLGLHSYTLGMNHLADLTVDEFRKTMNGYRRGSRERHEGHHTSTFLAPEN-YEVPQSMDWRDQGLVTPIKNQGQCGSCWAFSSTGALEGQWKRRSGELVPLSEQNLLDCSRPEGTEGCGGGWMDDAFQYVLDQGGIDSESDYPYTATDVDSCHYDPSRMVARISGFVDIHKGSEKDLITAVASVGPVSVAIDAGHQSFQLYESGIYYEPECNCTELDHAVLVVGFGVKGRGENGKKFWIVKNRRGLQCGGEIYLEVAVDKRCFCGL 338          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003800.1 (pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 gene:ENSPMAG00000003453.1 transcript:ENSPMAT00000003800.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 321.242 bits (822), Expect = 3.080e-109
Identity = 163/290 (56.21%), Postives = 205/290 (70.69%), Query Frame = 1
Query:  253 RRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPIN---KNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKE-GNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG-KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            RR+IWE+NL+ I  HN+E+ +GKH++ +G+N F DMT EE++  +LG +  N   K      F+AP    + P+SVDWR +GYVT VKNQ +CGSCWSFSTTGSLEGQHKRKTG L+SLSEQ LVDCS   GN GCNGGLM NAF YI+K+ G++SEE Y Y  +    CKY+     A  TG+V+I +G+E+ L  AVA+VGP+SVAIDAS  +F  Y  GIY +K C S  ++H VL VGYG  E    FW+VKNSWG QWG  GY++M +D +N CGIA  ASYPLV
Sbjct:    8 RRMIWEQNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTGEEFQQVMLGFRGWNGTSKAPRGATFMAPA-FFEAPESVDWRKQGYVTDVKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNYGCNGGLMINAFNYIKKNGGIDSEESYPYKGQGVETCKYNPKNKAAEVTGYVEIPEGDEEALKNAVASVGPVSVAIDASLNSFLYYISGIYKDKLC-SHIINHAVLVVGYGVDEKGDKFWLVKNSWGVQWGEKGYVRMARDDNNLCGIAVTASYPLV 295          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO46465 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPY5])

HSP 1 Score: 365.155 bits (936), Expect = 8.049e-126
Identity = 175/338 (51.78%), Postives = 233/338 (68.93%), Query Frame = 1
Query:   94 FIITMKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQK-DGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            F+  + + +L   C   +S            + +W+ +K    + Y    E  RR IW +NL +++KHN E     HSY L +N FAD+T  E++ + +G +  + +   + FL P + V LP  VDWR KG+VT VKNQ  CGSCW+FS+TGSLEGQH RKTG+L+SLSEQ LVDCSK +GNNGC GGLMD AF+YI+  DG+++E+ Y YTA++G C +    V A  TG+ D+++G+E DL  AVATVGPISVAIDA   +FQLYK G+Y+E  CSS QLDHGVLAVGYG E+ + +W+VKNSWG  WG++GYIKM++++ NQCGIAT ASYPLV
Sbjct:    4 FLACLLVAVLIAQCFSELSQ-----------DRQWHAWKDFHGKTYTGEEEDLRRAIWNDNLEIVKKHNAE----NHSYKLDMNHFADLTVTEFKQRFMGYRAASNSTGGSTFL-PLSNVQLPAEVDWRDKGFVTAVKNQGQCGSCWAFSSTGSLEGQHFRKTGKLVSLSEQNLVDCSKKYGNNGCEGGLMDYAFKYIKNNDGIDTEQSYPYTARDGQCHFKPGSVGATVTGYTDVQRGSEGDLQSAVATVGPISVAIDAGHSSFQLYKTGVYSEPDCSSTQLDHGVLAVGYGAEDGKDYWLVKNSWGEGWGMNGYIKMSRNKDNQCGIATQASYPLV 325          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO36727 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHX1])

HSP 1 Score: 352.443 bits (903), Expect = 9.312e-121
Identity = 170/338 (50.30%), Postives = 231/338 (68.34%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIEL-TRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTR---TIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDG-LESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            MK+++ A       S   +KF+ +E   ++W  +K+   +KY ++ E   R+ IW +NL+ IQKHN E     HS+ L +N   D+T +E+R    G++    NYT+   + FLAP + V +P +VDWR +GYVTPVKNQ  CGSCW+FSTTGSLEGQ+ +KTG+L+SLSEQ LVDCS  +GNNGC GGLMD AF+YI+++G +++EE Y Y A+   C++  S + A  TGFVD+  G+E+ L  A  TVGPISVAIDA   +FQ Y  G+YN   CSS  LDHGVL VGYG      +W+VKNSWG +WG+ GYI M+++++NQCG+AT ASYPLV
Sbjct:    1 MKLLVAACLLFAVASGFVVKFDEDE---QQWQAWKLFHTKKYTTVTEEGARKAIWRDNLKKIQKHNAE----GHSFTLAMNHLGDLTQDEFRYFYTGMRSHYSNYTKKQGSAFLAPSH-VQVPDTVDWRKEGYVTPVKNQGQCGSCWAFSTTGSLEGQNFKKTGKLVSLSEQNLVDCSTAYGNNGCQGGLMDYAFKYIKENGGIDTEESYPYEARNDRCRFQKSNIGAVDTGFVDVTHGDEEALKTAAGTVGPISVAIDAGHMSFQFYHSGVYNNAGCSSTSLDHGVLVVGYGTYQGSDYWLVKNSWGERWGMEGYIMMSRNKNNQCGVATQASYPLV 330          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45852 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL9])

HSP 1 Score: 344.354 bits (882), Expect = 1.770e-117
Identity = 174/338 (51.48%), Postives = 231/338 (68.34%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELT-RRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTR---TIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDG-LESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            M+ V+ AV   +S +      E  +  N  W  +K    ++Y +  E T R  IW+ NL+ I  HN     GKHS+ L +N   DMT+ E    +LGLK      ++     FL P N V +  S+DWR+KGYVTPVKNQ  CGSCW+FSTTG+LEGQH RKTG+L+SLSEQ LVDCS  +GNNGC GGLMDNAFQYI+++G +++E+ Y Y AK+G C Y+ S + A  TGFVDI  G+E  L +A+A+VGPIS+AIDAS+ TF  Y  G+Y++  CSS +LDHGVLAVGYG ++ + +W+VKNSWGP WG  GYIK+ ++ H++CG+A+ ASYPLV
Sbjct:    1 MEAVIFAVLLCISSALAMPPMEPLQDPN--WKAWKSFHGKEYPNKNEETMRNFIWQNNLKKIVTHN----EGKHSFKLAMNHLGDMTSLEISQTLLGLKLKKHAESQPKGATFLPPAN-VKVVDSIDWRSKGYVTPVKNQGQCGSCWAFSTTGALEGQHFRKTGKLVSLSEQNLVDCSGKYGNNGCEGGLMDNAFQYIKENGGIDTEKSYPYLAKDGVCHYNKSAIGAKDTGFVDIPTGDENALQQALASVGPISIAIDASQSTFHFYHQGVYDDPDCSSTRLDHGVLAVGYGTDDGKDYWLVKNSWGPSWGEEGYIKIARNDHDKCGVASKASYPLV 331          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRH6])

HSP 1 Score: 339.347 bits (869), Expect = 1.259e-115
Identity = 166/337 (49.26%), Postives = 226/337 (67.06%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIE-LTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTR--TIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            MK+ L+    V S     ++F      + EW  +K    + Y  + E  TR  IW++NL  I++HN E     HSY + +N   D+T +E+R   LG++  + +  R    ++ P N V +P SVDW  KGYVT VKNQ  CGSCW+FSTTGS+EGQH RKTG L+SLSEQ L+DCS  +GNNGC GGLMDNAF+YI+ + G+++E  Y Y  ++G+C + +S V A  TG+ DI +G+E+ L  AVATVGP+SVA+DAS+  +Q Y  G+Y+   CSS QLDHGVL +GYG  N Q +W+VKNSWG  WG+ GYI M+++++NQCGIA+ ASYPLV
Sbjct:    1 MKVFLVLCVLVASSRGWSVRF----GQDSEWVAWKSYHGKSYSDVHEERTRMAIWQQNLEKIKRHNAE----DHSYKMAMNHLGDLTEDEFRYFYLGVRAHHNSTKRGWATYMPPSN-VKIPSSVDWSQKGYVTGVKNQGQCGSCWAFSTTGSVEGQHFRKTGSLVSLSEQNLIDCSGSYGNNGCQGGLMDNAFRYIESNGGIDTESSYPYLGQQGSCHFSSSHVGARVTGYQDIPQGSEQALQSAVATVGPVSVAVDASQ--WQFYSSGVYDNPYCSSTQLDHGVLVIGYGNYNGQDYWLVKNSWGYSWGVEGYIMMSRNKNNQCGIASSASYPLV 326          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO42751 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0K3])

HSP 1 Score: 211.46 bits (537), Expect = 2.443e-66
Identity = 125/287 (43.55%), Postives = 174/287 (60.63%), Query Frame = 1
Query:  262 IWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGL---KPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQK-DGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKS--CSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            I+E N+R   K   + D G   Y  G   F+D++ EE+R + +     KP+ +     I L      D+P+SVDWR KG VTPVKNQ +CGSCW+FSTTG++EGQ+  KTG+L+SLSEQ+LVDC     + GC GGL  NA++ I+K  GLESE DY Y   +  CK++ ++V       V I K +EK++A  +A  GPIS+ I+A+    Q Y GGI +     C+   L+HGVL VGYG +N   +WI+KNSWGP WG  GY  + +     CG+ TM +  ++
Sbjct:    3 IFESNMRKAAKMQ-KMDSGTAQY--GPTIFSDLSEEEFRKQKMMPGWGKPLYEMKDAEIPLG-----DIPESVDWRDKGVVTPVKNQGSCGSCWAFSTTGNIEGQYAIKTGKLVSLSEQELVDCDTI--DKGCEGGLPSNAYKQIEKLGGLESESDYPYKGADSKCKFNKAEVKVTINSSVVISK-DEKEIAAWLAKNGPISIGINAN--AMQFYMGGIAHPWKIFCNPSSLNHGVLIVGYGVKNGTPYWIIKNSWGPSWGEKGYYLIYRG-GGCCGLNTMCTSAVI 275          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl (cathepsin L [Source:NCBI gene;Acc:100049246])

HSP 1 Score: 363.614 bits (932), Expect = 1.549e-124
Identity = 177/318 (55.66%), Postives = 229/318 (72.01%), Query Frame = 1
Query:  172 VNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPI-NKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGN-CKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKE----NNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            ++  L++ W ++K    + Y    E  RRL+WE+NLR I+ HN+E+ +GKHSY LG+N F DMT+EE+R  + G K    + Y+ ++F+ P N ++ P++VDWR KGYVTPVK+Q  CGSCW+FSTTG+LEGQ  RKTG+L+SLSEQ LVDCS+P GN GCNGGLMD AFQY++ + GL+SE+ Y Y   +   C+Y+A     + TGFVDI  G E+ L KAVA+VGP+SVAIDA   +FQ Y+ GIY EK CSS +LDHGVL VGYG E    + + +WIVKNSW  +WG  G+I M KDRHN CGIAT ASYPLV
Sbjct:   20 LDPQLDQHWQLWKGWHSKNYHEKEEGWRRLVWEKNLRKIELHNLEHSMGKHSYRLGMNHFGDMTHEEFRQIMNGYKRREQRKYSGSLFMEP-NFLEAPRAVDWRDKGYVTPVKDQGQCGSCWAFSTTGALEGQQFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDNQGLDSEDFYPYKGTDDQPCQYNAQYSAVNDTGFVDIPSGKERALMKAVASVGPVSVAIDAGHESFQFYQSGIYFEKECSSDELDHGVLVVGYGFEGEDVDGKKYWIVKNSWSEKWGDKGFIYMAKDRHNHCGIATAASYPLV 336          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl.1 (cathepsin L1 [Source:NCBI gene;Acc:101171789])

HSP 1 Score: 357.451 bits (916), Expect = 3.577e-122
Identity = 179/311 (57.56%), Postives = 220/311 (70.74%), Query Frame = 1
Query:  193 EWNMYKIQFQRKYESIIE-LTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYR--VKVLGLKPINKNYTR---TIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDG-LESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            E++ ++++F R Y S  E   RR  W  N +L+  HNI  D G  SY LG+  FADM NEEY+  +    L   N +  R   T F  PEN  DLP +VDWR KGYVT VK+Q  CGSCW+FS TGSLEGQ  RKTG+L+SLSEQQLVDCS  +GN GC GGLMD+AF+YIQ  G +++EE Y Y A++G C+Y    V A CTG+VD+  G+E  L +AVAT+GPISV IDAS  +FQLY+ G+Y+E  CSS +LDHGVLAVGYG EN Q +W+VKNSWG  WG  GYIKM+K++ NQCGIAT ASYPLV
Sbjct:   30 EFHAWRLKFGRTYSSPTEEAQRRQTWLNNRKLVLVHNILADQGIKSYRLGMTYFADMENEEYKRLISQGCLGSFNASLPRRGSTFFRLPENK-DLPAAVDWRDKGYVTDVKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNMGCGGGLMDDAFRYIQATGGIDTEESYPYEAEDGECRYKPDAVGATCTGYVDVSSGDEDALQEAVATIGPISVGIDASHISFQLYESGLYDEPQCSSSELDHGVLAVGYGSENGQDYWLVKNSWGLTWGDQGYIKMSKNKSNQCGIATAASYPLV 339          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss (cathepsin S [Source:NCBI gene;Acc:100049247])

HSP 1 Score: 309.301 bits (791), Expect = 2.036e-103
Identity = 154/314 (49.04%), Postives = 201/314 (64.01%), Query Frame = 1
Query:  172 VNEALNEEWNMYKIQFQRKY-ESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLG-LKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            V   L++ WN++K  + + Y   I E  RR IWEENL +I  HN+E  LG HSY L +N   D+T EE    + G + P+     R  +   +    +P+SVDWR  G VT VK Q  CGSCW+FS  G+LEGQ K+ TG L SLS Q LVDCS  +GN GC GG M NAFQY+ K+ G+ S+  Y Y  K   CKYD+    A+CTG+  + KG+E  L   VAT+GPISVAIDAS+P F  Y+ G+Y + SC S  ++HGVL VGYG EN + +W+VKNSWG ++G  GYIKM ++R NQCGIA  A +P++
Sbjct:   17 VRSHLDQHWNLWKKTYSKTYSHEIEEFGRRRIWEENLEMISVHNLEVSLGLHSYELAMNHLGDLTIEELIASLTGTVAPVG--LERIHYDLVKINTSVPESVDWREGGLVTSVKTQGRCGSCWAFSAVGALEGQLKKTTGILTSLSPQNLVDCSTKYGNYGCKGGFMSNAFQYVIKNQGISSDAAYPYIGKRDKCKYDSKHRAANCTGYNFLPKGDEFALKVGVATIGPISVAIDASRPKFLFYRHGVYKDHSC-SHNVNHGVLVVGYGTENGEDYWLVKNSWGERYGDGGYIKMARNRRNQCGIALYACFPVM 327          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss2.1 (cathepsin S [Source:NCBI gene;Acc:101165175])

HSP 1 Score: 296.204 bits (757), Expect = 4.027e-98
Identity = 144/327 (44.04%), Postives = 207/327 (63.30%), Query Frame = 1
Query:  133 CVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIE-LTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKP-INKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQY-IQKDGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            CV + SA   + +++      W ++K    + Y S  E + RR +WE NL LI  HN+EY +G H+Y L +N   D+T EE   +   L+P  N      +F+    + ++P  +DWR K  VT VK Q +CGSCW+FS  G+LEGQ  RKTG+L+ LS Q LVDCS  +GN+GCNGG M  AFQY I   G++S+  Y Y     NC Y +    A+C+ +  + +G+E  L +A+AT+GPISVAIDA++P F  Y+ G+Y++ SC S+ ++HGVLAVGYG  N Q +W+VKNSWG  +G  GYI+M +++++QCGIA    YP++
Sbjct:   20 CVGAASAFDSRLDIH------WELWKKTHSKHYPSEEEDVHRRDLWERNLMLITMHNLEYSMGLHTYDLSMNHMGDLTQEEILQQFASLRPPTNLKREPHLFVGASGSNNIPDEMDWRQKNCVTSVKMQGSCGSCWAFSAVGALEGQLCRKTGKLVDLSPQNLVDCSSKYGNHGCNGGFMHQAFQYVIDNQGIDSDAGYPYVGVTQNCHYSSEYRAANCSQYSFLPEGDEGALKEAIATIGPISVAIDATRPRFAFYRSGVYDDSSC-SQNVNHGVLAVGYGTLNGQDYWLVKNSWGTTFGEQGYIRMARNKNDQCGIAMYGCYPIM 339          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsk (cathepsin K [Source:NCBI gene;Acc:101164922])

HSP 1 Score: 294.664 bits (753), Expect = 1.120e-97
Identity = 148/329 (44.98%), Postives = 216/329 (65.65%), Query Frame = 1
Query:  133 CVVSISAGKLKFEVNEA-LNEEWNMYKIQFQRKYESIIEL-TRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLK-PINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKD-GLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG-KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            CV+ + +  +  +++E  L+  W  +K+   ++Y ++ E   RR IWE+NLR+I+ HN E  LG H+Y LG+N+F DMT EE   ++ GL+ P+N    R       + + LPKSVD+R KG VT VKNQ +CGSCW+FS+ G+LEGQ  +KTG L+ LS Q LVDC     N+GC GG M NAF+Y+Q++ G++SE  Y Y  ++  C+Y+ S + A   G+ ++ +G+E  LA A+   GP+SV IDAS+ +F  Y+ GIY +++C+   ++H VLAVGYG     + FWIVKNSWG  WG  GY+ M ++R N CGIA +ASYP++
Sbjct:    6 CVLLLLSASVMSQMDETTLDAHWEEWKMTHTKEYITVEEEGIRRAIWEKNLRMIEAHNQEAALGMHTYTLGMNQFGDMTQEEVVERMTGLQMPLNPE-PRVPMETDGSLIKLPKSVDYRKKGMVTSVKNQGSCGSCWAFSSVGALEGQLAKKTGNLVDLSPQNLVDCVTE--NDGCGGGYMTNAFKYVQENGGIDSEAAYPYMGEDQPCRYNVSGLAAQIKGYKEVPEGDEHALAVALFKAGPVSVGIDASQNSFLYYQKGIYFDRNCNKEDINHAVLAVGYGVNAKGKKFWIVKNSWGETWGNKGYVLMARNRGNVCGIANLASYPVM 331          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049722.1 (SMESG000049722.1)

HSP 1 Score: 690.649 bits (1781), Expect = 0.000e+0
Identity = 331/333 (99.40%), Postives = 331/333 (99.40%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQK GLESE DYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV
Sbjct:    1 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKYGLESEADYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 333          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049723.1 (SMESG000049723.1)

HSP 1 Score: 484.567 bits (1246), Expect = 1.589e-172
Identity = 226/333 (67.87%), Postives = 267/333 (80.18%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            M+I++L    + ++SA   +F +N  LN+EW  YK QF +KY S+ E++RRLIWE+NL+ IQ+HN+E+DLGKH+Y LGLN FADMTNEE+R   LG+ P   N+T + F+APEN   LP SVDWRTKG+VTPVKNQ  CGSCWSFSTTGSLEGQH RKT  LIS SEQQLVDCS  FGNNGC+GGLMD+AFQYIQ+ G+E+E  Y YTA++GNC YD SKVV  CTGF DI  GNE+ LA AVATVGPISVAIDAS  +FQLYK GIYNE  CSS QLDHGVLA+GYG EN ++FW+VKNSWG  WG+ GYIKM+KD+ NQCGIATMASYPLV
Sbjct:    1 MQIIILVSLFLAAVSAAPQQFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFT-SHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGIATMASYPLV 332          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014166.1 (SMESG000014166.1)

HSP 1 Score: 483.411 bits (1243), Expect = 5.043e-172
Identity = 228/332 (68.67%), Postives = 270/332 (81.33%), Query Frame = 1
Query:  112 IVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTR-TIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            IV+L+VF +V+I A +  F +N  LNE+W +YK QF+R+YE + E+TRR+IWE+NL  I++HN+EYDLGKH+YYLGLNE+AD+TNEE++ K LG K + ++ T+ + F+APEN   LP +VDWRTKGYVTPVKNQ  CGSCW+FSTTGSLEGQH RKTG L+S SEQQLVDCS  +GN GC GGLMDNAF YI K GLESE DY YTA +G CKYD SKVV  C+GF DIK GNE DLA AVATVGP+SVAIDAS  +FQLYKGGIYNE  CS  QLDHGVLAVGYG EN  ++W+VKNSWG  WGLSGYIKM+KDR NQCGI+T AS+PLV
Sbjct:    5 IVILSVF-LVAIQARRPTFSLNSELNEDWELYKTQFKRQYEPLTEITRRIIWEQNLEYIRQHNLEYDLGKHTYYLGLNEYADLTNEEFKAKFLG-KILTRSSTKGSQFMAPENMGALPTTVDWRTKGYVTPVKNQQQCGSCWAFSTTGSLEGQHFRKTGSLVSFSEQQLVDCSGAYGNEGCGGGLMDNAFNYIMKYGLESERDYPYTATDGKCKYDRSKVVGTCSGFTDIKHGNESDLAVAVATVGPVSVAIDASHYSFQLYKGGIYNEPQCSPDQLDHGVLAVGYGSENGGNYWLVKNSWGISWGLSGYIKMSKDRKNQCGISTSASFPLV 334          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014167.1 (SMESG000014167.1)

HSP 1 Score: 480.33 bits (1235), Expect = 7.920e-171
Identity = 224/331 (67.67%), Postives = 265/331 (80.06%), Query Frame = 1
Query:  112 IVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
             VL++VF +V+I A +  F +N  LN++W +YK QF+R+YE + E+TRR+IWE+NL  I++HN+EYDLGKH+YYLGLNE+AD+TNEE++ K LG      +   + F+APEN   LP +VDWRTKGYVTPVKNQ  CGSCW+FSTTGSLEGQH RKTG L+S SEQQLVDCS  +GN GC GGLMDNAF YI K GLESE DY YTA +G CKYD SKVV  C+GF DIK GNE DLA AVATVGP+SVAIDAS  +FQLYKGGIYNE  CS  QLDHGVLAVGYG EN  ++W+VKNSWG  WGLSGYIKM+KDR+NQCGI+T AS+PLV
Sbjct:    4 FVLISVF-LVAIQARRPTFSLNSELNKDWELYKTQFKRQYEPLTEITRRIIWEQNLEYIRQHNLEYDLGKHTYYLGLNEYADLTNEEFKAKFLGKILTRSSRKGSQFMAPENMGALPTTVDWRTKGYVTPVKNQQQCGSCWAFSTTGSLEGQHFRKTGSLVSFSEQQLVDCSGAYGNEGCGGGLMDNAFNYIMKYGLESERDYPYTATDGKCKYDRSKVVGTCSGFTDIKHGNESDLAVAVATVGPVSVAIDASHYSFQLYKGGIYNEPQCSPDQLDHGVLAVGYGSENGGNYWLVKNSWGISWGLSGYIKMSKDRNNQCGISTSASFPLV 333          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014171.1 (SMESG000014171.1)

HSP 1 Score: 436.417 bits (1121), Expect = 1.653e-153
Identity = 203/333 (60.96%), Postives = 246/333 (73.87%), Query Frame = 1
Query:  106 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDGLESEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 1104
            MK  ++    +V+I AG  +F VN  LNEEW ++K QF ++YE + E+ RR+IWEENL  I++HN+EYDLGKHSY LGLNE++D+TN E++ K+LG +    N   + F+ PEN   LP SVDWRTKGYVTPVKNQ  CGSCW+FS TG+LEGQH RKTG+LISLSEQQLVDCS+P+GN GC GG    AF Y+ K G+ESE+DY Y  KE  C YD SKVVA+ T +   K GNE DLA AVATVGP+S+ IDA  P FQ YK GIYN  +CSS  LDH VL VGYG  N  ++WIVKNSWGP WG+ GYI M+KD+ NQCGIAT A YP+V
Sbjct:    1 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQHFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKPGNESDLAAAVATVGPLSIGIDADHPGFQHYKNGIYNNPTCSSEYLDHAVLVVGYGSLNGNNYWIVKNSWGPHWGIEGYILMSKDKDNQCGIATQAVYPVV 333          
The following BLAST results are available for this feature:
BLAST of Cathepsin L2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CTSV2.615e-12454.93cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538][more]
CTSV2.615e-12454.93cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538][more]
CTSL5.898e-12354.93cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSL5.898e-12354.93cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSK5.210e-10847.90cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536][more]
back to top
BLAST of Cathepsin L2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cpl-12.292e-10348.46CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-12.014e-7957.87CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-12.014e-7957.87CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
R09F10.14.423e-5836.05pep chromosome:WBcel235:X:8323592:8325046:1 gene:W... [more]
tag-1965.723e-5838.31pep chromosome:WBcel235:V:8594914:8597500:1 gene:W... [more]
back to top
BLAST of Cathepsin L2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cp14.219e-11250.31gene:FBgn0013770 transcript:FBtr0087592[more]
Cp11.071e-11150.31gene:FBgn0013770 transcript:FBtr0087593[more]
Cp11.253e-10750.81gene:FBgn0013770 transcript:FBtr0339955[more]
Cp16.148e-9856.90gene:FBgn0013770 transcript:FBtr0304021[more]
CG53671.163e-7038.39gene:FBgn0032228 transcript:FBtr0080055[more]
back to top
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:dkey-269i1.41.556e-12753.24si:dkey-269i1.4 [Source:ZFIN;Acc:ZDB-GENE-121214-3... [more]
ctsla2.997e-12752.62cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106][more]
ctsla2.997e-12752.62cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106][more]
si:dkey-239j18.23.115e-12653.71si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-... [more]
si:dkey-239j18.23.115e-12653.71si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-... [more]
back to top
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fcrl29.692e-13055.99Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
fcrl21.483e-12954.81Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
harbi11.733e-10549.36harbinger transposase derived 1 [Source:Xenbase;Ac... [more]
ano18.867e-10443.98anoctamin 1, calcium activated chloride channel [S... [more]
mdk8.871e-10242.77midkine [Source:Xenbase;Acc:XB-GENE-488502][more]
back to top
BLAST of Cathepsin L2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ctsl1.134e-12057.10cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
Ctsl1.134e-12057.10cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
BC0516656.417e-10949.25cDNA sequence BC051665 [Source:MGI Symbol;Acc:MGI:... [more]
Ctsll37.582e-10848.95cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917... [more]
Ctsk1.270e-10546.18cathepsin K [Source:MGI Symbol;Acc:MGI:107823][more]
back to top
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O60911|CATL2_HUMAN1.256e-12354.93Cathepsin L2 OS=Homo sapiens OX=9606 GN=CTSV PE=1 ... [more]
sp|P07711|CATL1_HUMAN2.832e-12254.93Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 ... [more]
sp|Q9GKL8|CATL1_CHLAE1.247e-12154.79Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CT... [more]
sp|Q5E998|CATL2_BOVIN2.766e-12155.22Cathepsin L2 OS=Bos taurus OX=9913 GN=CTSV PE=2 SV... [more]
sp|P25975|CATL1_BOVIN2.858e-12155.22Cathepsin L1 OS=Bos taurus OX=9913 GN=CTSL PE=1 SV... [more]
back to top
BLAST of Cathepsin L2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2U8U4474.946e-17567.87Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1[more]
A0A087UR189.741e-13356.33Cathepsin L (Fragment) OS=Stegodyphus mimosarum OX... [more]
A0A267H1I61.532e-13156.29Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8GVB72.702e-13156.29Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A087UR193.014e-13154.17Cathepsin L (Fragment) OS=Stegodyphus mimosarum OX... [more]
back to top
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:dkey-26g8.51.594e-12853.20cathepsin L1-like [Source:NCBI gene;Acc:103028700][more]
ctsl.15.369e-12055.66cathepsin L1-like [Source:NCBI gene;Acc:103023607][more]
ctsla1.520e-11552.48cathepsin L1-like [Source:NCBI gene;Acc:103043056][more]
ENSAMXT00000042132.13.406e-11248.96cathepsin L1-like [Source:NCBI gene;Acc:103023924][more]
ENSAMXT00000048039.13.406e-11248.96cathepsin L1-like [Source:NCBI gene;Acc:103023924][more]
back to top
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000006499.18.754e-12252.20pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 g... [more]
ENSPMAT00000011285.13.960e-12057.86pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gen... [more]
ENSPMAT00000010475.18.350e-11657.09pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 ... [more]
ENSPMAT00000008535.11.949e-11048.34pep scaffold:Pmarinus_7.0:GL478103:36116:54424:1 g... [more]
ENSPMAT00000003800.13.080e-10956.21pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 g... [more]
back to top
BLAST of Cathepsin L2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO464658.049e-12651.78Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO367279.312e-12150.30Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458521.770e-11751.48Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO459531.259e-11549.26Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO427512.443e-6643.55Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Cathepsin L2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl1.549e-12455.66cathepsin L [Source:NCBI gene;Acc:100049246][more]
ctsl.13.577e-12257.56cathepsin L1 [Source:NCBI gene;Acc:101171789][more]
ctss2.036e-10349.04cathepsin S [Source:NCBI gene;Acc:100049247][more]
ctss2.14.027e-9844.04cathepsin S [Source:NCBI gene;Acc:101165175][more]
ctsk1.120e-9744.98cathepsin K [Source:NCBI gene;Acc:101164922][more]
back to top
BLAST of Cathepsin L2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000049722.10.000e+099.40SMESG000049722.1[more]
SMESG000049723.11.589e-17267.87SMESG000049723.1[more]
SMESG000014166.15.043e-17268.67SMESG000014166.1[more]
SMESG000014167.17.920e-17167.67SMESG000014167.1[more]
SMESG000014171.11.653e-15360.96SMESG000014171.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30017940 ID=SMED30017940|Name=Cathepsin L2|organism=Schmidtea mediterranea sexual|type=transcript|length=1165bp
CCTGATTGTGTGCTGTAAACAAATGCAACCTCACCGTATGTCATTATCAT
AATTGAAAAGATTTACGTATAAATTCAACGTATTTTTGTCAAATTTATTA
TAACAATGAAGATCGTTCTACTTGCAGTATTTTGCGTTGTCTCGATTAGT
GCTGGAAAATTAAAGTTTGAAGTCAACGAGGCCCTGAACGAGGAATGGAA
CATGTACAAGATCCAGTTCCAGAGAAAATACGAATCCATTATCGAATTAA
CTAGACGACTAATTTGGGAAGAAAATCTCAGATTGATACAGAAACACAAT
ATCGAATACGATCTCGGAAAACATTCGTATTACCTCGGTCTGAATGAATT
CGCAGACATGACCAACGAAGAATACAGAGTAAAGGTTCTCGGACTGAAAC
CAATAAACAAAAATTACACGAGAACAATTTTCCTGGCTCCGGAAAATACT
GTCGATCTCCCTAAATCAGTTGATTGGAGAACAAAAGGATACGTAACTCC
CGTGAAAAATCAGGCTAATTGTGGATCTTGTTGGTCGTTCTCGACTACTG
GCTCACTAGAGGGTCAACATAAGCGTAAAACTGGTCAGTTAATTTCCTTA
TCCGAACAGCAACTCGTAGACTGCAGTAAACCATTTGGTAATAATGGATG
CAATGGTGGCCTCATGGATAACGCATTTCAGTACATTCAAAAAGACGGAT
TGGAATCGGAAGAAGATTATTCCTACACAGCAAAAGAAGGTAACTGTAAG
TATGACGCCTCAAAGGTTGTTGCTCATTGCACAGGATTTGTCGATATTAA
AAAAGGAAACGAGAAAGACTTAGCAAAGGCTGTCGCAACAGTCGGTCCGA
TATCAGTGGCAATCGACGCCAGTAAACCAACTTTTCAATTATATAAAGGT
GGAATCTATAATGAAAAATCATGCTCCTCCCGCCAATTGGACCATGGGGT
CCTTGCAGTTGGTTATGGGAAAGAGAACAATCAACATTTCTGGATTGTTA
AAAACAGTTGGGGACCACAATGGGGACTTTCGGGGTACATAAAAATGACA
AAGGATCGACACAATCAATGTGGAATAGCTACGATGGCTAGCTATCCTCT
TGTTTGAGACTGCAATATTTATTTTGTTTTAATTTTATACATTTTATTTT
ATTTGTGAAAAAAAA
back to top

protein sequence of SMED30017940-orf-1

>SMED30017940-orf-1 ID=SMED30017940-orf-1|Name=SMED30017940-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=334bp
MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTR
RLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPI
NKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGS
LEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKDGLE
SEEDYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPIS
VAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKN
SWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000429neoblast
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR039417Peptidase_C1A_papain-like
IPR038765Papain-like_cys_pep_sf
IPR000668Peptidase_C1A_C
IPR013201Prot_inhib_I29
IPR025660Pept_his_AS
IPR000169Pept_cys_AS
IPR025661Pept_asp_AS
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
Vocabulary: molecular function
TermDefinition
GO:0008234cysteine-type peptidase activity
GO:0008233peptidase activity
GO:0016787hydrolase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000668Peptidase C1A, papain C-terminalPRINTSPR00705PAPAINcoord: 280..290
score: 60.67
coord: 136..151
score: 56.64
coord: 295..301
score: 67.94
IPR000668Peptidase C1A, papain C-terminalSMARTSM00645pept_c1coord: 118..332
e-value: 3.2E-126
score: 435.3
IPR000668Peptidase C1A, papain C-terminalPFAMPF00112Peptidase_C1coord: 118..331
e-value: 3.5E-85
score: 285.5
IPR013201Cathepsin propeptide inhibitor domain (I29)SMARTSM00848Inhibitor_I29_2coord: 31..90
e-value: 3.8E-24
score: 96.2
IPR013201Cathepsin propeptide inhibitor domain (I29)PFAMPF08246Inhibitor_I29coord: 31..90
e-value: 1.1E-12
score: 48.2
NoneNo IPR availableGENE3DG3DSA:3.90.70.10coord: 21..333
e-value: 1.8E-114
score: 384.5
NoneNo IPR availablePANTHERPTHR12411CYSTEINE PROTEASE FAMILY C1-RELATEDcoord: 7..332
NoneNo IPR availablePANTHERPTHR12411:SF649CATHEPSIN L,-LIKE-RELATEDcoord: 7..332
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..16
score: 0.695
IPR000169Cysteine peptidase, cysteine active sitePROSITEPS00139THIOL_PROTEASE_CYScoord: 136..147
IPR025660Cysteine peptidase, histidine active sitePROSITEPS00639THIOL_PROTEASE_HIScoord: 278..288
IPR025661Cysteine peptidase, asparagine active sitePROSITEPS00640THIOL_PROTEASE_ASNcoord: 295..314
IPR039417Papain-like cysteine endopeptidaseCDDcd02248Peptidase_C1Acoord: 119..331
e-value: 2.53068E-124
score: 353.082
IPR038765Papain-like cysteine peptidase superfamilySUPERFAMILYSSF54001Cysteine proteinasescoord: 23..332