Timeless circadian clock
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017903 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11Note: Hover over icons to view figure legend
Homology
BLAST of Timeless circadian clock vs. Ensembl Human
Match: TIMELESS (timeless circadian regulator [Source:HGNC Symbol;Acc:HGNC:11813]) HSP 1 Score: 325.479 bits (833), Expect = 8.170e-92 Identity = 306/996 (30.72%), Postives = 501/996 (50.30%), Query Frame = 1
Query: 88 DLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESAS----DQQLRRQRELELMAKSA--ENPRVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLM-SAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKE----WTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNPWTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKN---SKLIPN 3018
+L A + LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L ++ D LFD VIRL++NLTQP+ +CF LPK+ F++V LQ K F VLS + ++ WE+R E+++LL+ERIL+L+RNILH+ + + S HD L+ + SG DLL++L+++ EE+++ H LEI+SLMFR+Q+ E + + + S + ++ RQRE+ A R RFGG++ +Q +K+ R I+H H++ DL + K + K + +E + +S V L++FC FL+ YN LM + L R++ Q DETYY+WAL FFM R P VSET+++ FH++ Q Y + T ++ A S R++HL + AY+ELL +D +E R S IK+ +FY EY E++ L F Q R+FLR L+E + L +K+L+ F + K++K K K +Q I + +PS ++ + +W + E L A N E+ + D ++P + SE PV+ Q A+ +Q L + +A+ + +++WPE D + D EEEI++LK I+ A + + E G E+E E E ++E++ VQV E F+F +++ F VV + +L N TN+ +++++H +A K +L+QL +F FN+ L DP + + I VN+ K +E+LF KN E GY + DD + W+ E E L L+ ++D+ G D I + + +TR+QI++ LV +GL S K+ + K WT D++ L L EE RD + IM + A RSR ++ K+L LGLV + +L + + S ++PN
Sbjct: 9 ELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHHQDKPLFDAVIRLMVNLTQPALLCFGN-LPKEPSFRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEERQEEDNLLIERILLLVRNILHVPADLDQEKKIDDDASAHDQLLWAIHLSGLDDLLLFLASSSAEEQWSLHVLEIVSLMFRDQNPEQLAGVGQGRLAQERSADFAELEVLRQREMAEKKTRALQRGNRHSRFGGSYIVQGLKSIGERDLIFHKGLHNLRNYSSDLGKQPK--KVPKRRQAARELSIQRRSALNVRLFLRDFCSEFLENCYNRLMGSVKDHLLREKAQQHDETYYMWALAFFMAFNRAASFRPGLVSETLSVRTFHFIEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDISPDEAVRESSRIIKNNIFYVMEYRELFLALFRKFDERCQPRSFLRDLVETTHLFLKMLE---RFCRSRGNLVVQNKQKKRRKKKKKVLDQAIVSGNVPSSPEE----VEAVWPALAEQLQCCAQNSELSM--------DSVVP-----FDAASEVPVEEQRAEAMVRIQDCLLAGQAPQALTLLRSAREVWPEGD--VFGSQDISPEEEIQLLKQILSAP--------LPRQQGPEERGAE-EEEEEEEEEEEELQVVQVSEKEFNFLDYLKRFACSTVVRAYVLLLRSYQQNSAHTNHCIVKMLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGAYKELVTFAKYILGKFFALAAVNQ--KAFVELLFWKNTAVVREMTEGYGSLDDRSSSRRAPTWSPEEEAHLRELYLA--NKDV-EGQDVVEAILAHLNTVPRTRKQIIHHLVQMGLADSVKDFQRKGTHIVLWTGDQELELQRLFEEFRDSDDVLGHIMKNITAK-------RSRARIVDKLLALGLVAERRELYKKRQKKLASSILPN 958
BLAST of Timeless circadian clock vs. Ensembl Human
Match: TIMELESS (timeless circadian regulator [Source:HGNC Symbol;Acc:HGNC:11813]) HSP 1 Score: 324.709 bits (831), Expect = 1.146e-91 Identity = 307/996 (30.82%), Postives = 502/996 (50.40%), Query Frame = 1
Query: 88 DLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESAS----DQQLRRQRELELMAKSA--ENPRVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLM-SAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKE----WTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNPWTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKN---SKLIPN 3018
+L A + LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L ++ D LFD VIRL++NLTQP+ +CF LPK+ F++V LQ K F VLS + ++ WE+R E+++LL+ERIL+L+RNILH+ + I + S HD L+ + SG DLL++L+++ EE+++ H LEI+SLMFR+Q+ E + + + S + ++ RQRE+ A R RFGG++ +Q +K+ R I+H H++ DL + K + K + +E + +S V L++FC FL+ YN LM + L R++ Q DETYY+WAL FFM R P VSET+++ FH++ Q Y + T ++ A S R++HL + AY+ELL +D +E R S IK+ +FY EY E++ L F Q R+FLR L+E + L +K+L+ F + K++K K K +Q I + +PS ++ + +W + E L A N E+ + D ++P + SE PV+ Q A+ +Q L + +A+ + +++WPE D + D EEEI++LK I+ A + + E G E+E E E ++E++ VQV E F+F +++ F VV + +L N TN+ +++++H +A K +L+QL +F FN+ L DP + + I VN+ K +E+LF KN E GY + DD + W+ E E L L+ ++D+ G D I + + +TR+QI++ LV +GL S K+ + K WT D++ L L EE RD + IM + A RSR ++ K+L LGLV + +L + + S ++PN
Sbjct: 9 ELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHHQDKPLFDAVIRLMVNLTQPALLCFGN-LPKEPSFRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEERQEEDNLLIERILLLVRNILHVPADLDQEKIDDDA-SAHDQLLWAIHLSGLDDLLLFLASSSAEEQWSLHVLEIVSLMFRDQNPEQLAGVGQGRLAQERSADFAELEVLRQREMAEKKTRALQRGNRHSRFGGSYIVQGLKSIGERDLIFHKGLHNLRNYSSDLGKQPK--KVPKRRQAARELSIQRRSALNVRLFLRDFCSEFLENCYNRLMGSVKDHLLREKAQQHDETYYMWALAFFMAFNRAASFRPGLVSETLSVRTFHFIEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDISPDEAVRESSRIIKNNIFYVMEYRELFLALFRKFDERCQPRSFLRDLVETTHLFLKMLE---RFCRSRGNLVVQNKQKKRRKKKKKVLDQAIVSGNVPSSPEE----VEAVWPALAEQLQCCAQNSELSM--------DSVVP-----FDAASEVPVEEQRAEAMVRIQDCLLAGQAPQALTLLRSAREVWPEGD--VFGSQDISPEEEIQLLKQILSAP--------LPRQQGPEERGAE-EEEEEEEEEEEELQVVQVSEKEFNFLDYLKRFACSTVVRAYVLLLRSYQQNSAHTNHCIVKMLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGAYKELVTFAKYILGKFFALAAVNQ--KAFVELLFWKNTAVVREMTEGYGSLDDRSSSRRAPTWSPEEEAHLRELYLA--NKDV-EGQDVVEAILAHLNTVPRTRKQIIHHLVQMGLADSVKDFQRKGTHIVLWTGDQELELQRLFEEFRDSDDVLGHIMKNITAK-------RSRARIVDKLLALGLVAERRELYKKRQKKLASSILPN 957
BLAST of Timeless circadian clock vs. Ensembl Celegans
Match: tim-1 (pep chromosome:WBcel235:III:12240403:12250164:-1 gene:WBGene00006571.1 transcript:Y75B8A.22.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tim-1) HSP 1 Score: 174.866 bits (442), Expect = 1.054e-43 Identity = 175/685 (25.55%), Postives = 338/685 (49.34%), Query Frame = 1
Query: 91 LHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYL-KEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNST--ESASDQQLRRQRELELMAKSAENPRVKRFGGTFELQDIKTESGRPA--IYHHDINWSKIDLTRDRKLRRKA-KNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRF---FMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKES--AVSSYRKLHLVMSAYKELLEFCLMLDNH-QEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDD-GGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE---PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTD--DDNRVEEEIKILKDIMFANKFYKEEDLIK 2091
+ + LG E+ ++ ++ D S+RD++R+LR + + R+E G+ ++E L+ ++K + FD+ IRL++NL QP+ + + P D +++ +++E L+R K+ F D F + +I + ++ E+EDR E L+VERI++L++ + IN + S+G DS HD +++ +ESG L++++N E+ F L+I +L+ +EQ+AE + T ST + ++++ R+ E ++ ++ + RFGG++ ++ +K S + ++ N K + DRK +++A +N+ + +T H ++ +V L++ ++ +N LMK++ + + Q+Q + Y + ++F F+ + R++ L E +SE I + FH Q Y++N+ T + A S K + AY EL+ + H +EE R + + EY E+ ++ F S FLR L+ + +K+++ +FV + K K +K + + + ++ SE D L +W+E ++ + EV PE R DS+ PVD+Q K A +Q LR R AV ++ + LWPE + +TD D E++++ L+ ++ A+ +DL K
Sbjct: 5 VQGAVHALGYYEDGKYSREPDCYESIRDLIRYLREDGDDHTARIECGRHNLVEQDLVPMVKCEDLTDDEFDIAIRLMVNLCQPAISTMRGKPPADRDQWKMYWELEENLRRAKTAFSDAHFFTAIKKRIDNYFIDTEYEDRDERLRLVVERIVLLIKYVFSINPDTSEGRRTRIEDSSHDRVIIAFLESGIDKTLMHIANQPREKEFHVTILDIFALILKEQTAEDLATKSEEVSTAEQKKTEEEFRKIIENHVVKETQKRKSFSRFGGSYTIKGLKGISANSSQVVFKPIQNVEKHNFLDDRKAKKRAPRNRRPFEIDTNSHFASSEVRGMLRDMVIRIIETCFNRLMKSSKTTV-FVQVQKTSQINYFFLIKFVLRFVRLSRQDHLL-ERISECIGVEAFHENNVQLTEYVENATTLKGVEAKSHGLKAQYALGAYNELVLLHRYIYEHAKEENERKFAKRALEHIVNVEEYRELPIFIIKKFSSSVLSNNFLRELVLTTHHYMKLVE-------RFVKTGALKKVTKKVKVRKATKKSKMSEEDVRSEFDGMSKKDLDRLWEESKGLVLQILKKEV--------------PEMRGMNPIDSQLDVPVDAQQKFAKLSIQRSLRSRGFPAAVGLYHASRALWPESFKRGLTDFQDSPGEEDQLQELEQLLKADMKKVAKDLKK 666
BLAST of Timeless circadian clock vs. Ensembl Celegans
Match: tim-1 (pep chromosome:WBcel235:III:12240367:12250164:-1 gene:WBGene00006571.1 transcript:Y75B8A.22.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tim-1) HSP 1 Score: 174.866 bits (442), Expect = 1.054e-43 Identity = 175/685 (25.55%), Postives = 338/685 (49.34%), Query Frame = 1
Query: 91 LHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYL-KEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNST--ESASDQQLRRQRELELMAKSAENPRVKRFGGTFELQDIKTESGRPA--IYHHDINWSKIDLTRDRKLRRKA-KNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRF---FMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKES--AVSSYRKLHLVMSAYKELLEFCLMLDNH-QEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDD-GGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE---PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTD--DDNRVEEEIKILKDIMFANKFYKEEDLIK 2091
+ + LG E+ ++ ++ D S+RD++R+LR + + R+E G+ ++E L+ ++K + FD+ IRL++NL QP+ + + P D +++ +++E L+R K+ F D F + +I + ++ E+EDR E L+VERI++L++ + IN + S+G DS HD +++ +ESG L++++N E+ F L+I +L+ +EQ+AE + T ST + ++++ R+ E ++ ++ + RFGG++ ++ +K S + ++ N K + DRK +++A +N+ + +T H ++ +V L++ ++ +N LMK++ + + Q+Q + Y + ++F F+ + R++ L E +SE I + FH Q Y++N+ T + A S K + AY EL+ + H +EE R + + EY E+ ++ F S FLR L+ + +K+++ +FV + K K +K + + + ++ SE D L +W+E ++ + EV PE R DS+ PVD+Q K A +Q LR R AV ++ + LWPE + +TD D E++++ L+ ++ A+ +DL K
Sbjct: 5 VQGAVHALGYYEDGKYSREPDCYESIRDLIRYLREDGDDHTARIECGRHNLVEQDLVPMVKCEDLTDDEFDIAIRLMVNLCQPAISTMRGKPPADRDQWKMYWELEENLRRAKTAFSDAHFFTAIKKRIDNYFIDTEYEDRDERLRLVVERIVLLIKYVFSINPDTSEGRRTRIEDSSHDRVIIAFLESGIDKTLMHIANQPREKEFHVTILDIFALILKEQTAEDLATKSEEVSTAEQKKTEEEFRKIIENHVVKETQKRKSFSRFGGSYTIKGLKGISANSSQVVFKPIQNVEKHNFLDDRKAKKRAPRNRRPFEIDTNSHFASSEVRGMLRDMVIRIIETCFNRLMKSSKTTV-FVQVQKTSQINYFFLIKFVLRFVRLSRQDHLL-ERISECIGVEAFHENNVQLTEYVENATTLKGVEAKSHGLKAQYALGAYNELVLLHRYIYEHAKEENERKFAKRALEHIVNVEEYRELPIFIIKKFSSSVLSNNFLRELVLTTHHYMKLVE-------RFVKTGALKKVTKKVKVRKATKKSKMSEEDVRSEFDGMSKKDLDRLWEESKGLVLQILKKEV--------------PEMRGMNPIDSQLDVPVDAQQKFAKLSIQRSLRSRGFPAAVGLYHASRALWPESFKRGLTDFQDSPGEEDQLQELEQLLKADMKKVAKDLKK 666
BLAST of Timeless circadian clock vs. Ensembl Fly
Match: timeout (gene:FBgn0038118 transcript:FBtr0082712) HSP 1 Score: 237.269 bits (604), Expect = 5.302e-63 Identity = 269/983 (27.37%), Postives = 491/983 (49.95%), Query Frame = 1
Query: 70 MEKYLSDLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMD--TLKSSNSTESASDQQLRRQRELELMAKSAENP--RVKRFGGTFELQDIKTESGRPAIYHHDINW-SKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQAD-DETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWV-----YQQAMIYIDNSKTKESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEK-YRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLN-LPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPK-EWTDXXXXXXXXXXXXXQHEDILPGFDKASV--IESRFSDKNKTRRQILNRLVTLGLISSA---KELKNKKRENNPWTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGL 2961
M L+D+ A LG ++ +++ + D L+ ++ LRR+ + E R LG+ KV++ L+ +L Y + L DL+IRLL+ LT P+ + +++ PKD G ++F+++ ++LQ K+ F L K+ + RSE+++LL+ERIL+L+RN+L + N A+ S HD ++ + ++G DL++++ ++ +EE+F H LEI+ L+FREQSAE + +L+ S S + Q+L R E + A P R RFGGT+ ++++K+ S R I H + S ID R+++ ++++ + +E +S V L+E+C L+ YN L++ +L+R + D++Y LWA+RFFME R + L + VSE++++ FHWV + MI D + + A ++LH+ + ++ELL+ L L +++ R L + + V Y EY E LL ++ ++ FLR ++E + + IK+++ +F + +K + + ++ Q + P+ L W E+ + S ++ E+E+P + P+ +D + +D Q + + + LR +A+A+ +++WPE + E+E+ +L++I +N E + + K+ + +ED++ + E+ ++ + E F F F R +P +V ++ D P + + I+H IA K +L+Q KLF F + + + + L++ IF+++KF E N K+ E+LF K I EA+E GY ++ + K WT+E E EL LFEE Q P DK + I DK + RR +L +L LGL+ A + K+ + N W +E L L ++ R +P ++ ++N + RS+ +IK++L++ L
Sbjct: 1 MSILLADIDATCAALGYSDGQKYQAEPDAAEGLKHLIWILRRDLDNHEYRRHLGRSKVLQTDLVYMLPDYVHHEELSDLLIRLLVILTNPTLLLYREGAPKDNHGRKVFMELIDILQGYKAAFAKDKVWSALFEKLKQALEIAFAIRSEEQNLLIERILVLVRNVLQVPANPEAECRADNDASLHDQVIWALHQTGMLDLVLFVISSPDEEQFHLHGLEIVCLLFREQSAESLADASLQRSLSEKQRDQQELLAARRRERARRQARPPPGRHSRFGGTYVIRNMKSVSDRDVICHQALERVSSIDFDREKQQQKRSHRHIQ-EEAQVTRRSAFTVRLCLREYCIEVLRSAYNTLVRQVRRVLERNAGSSSHDDSYLLWAIRFFMEFNRLSGLQLQLVSESLSVQCFHWVLTRMQHDMDMIVSDKKQARLWA----KRLHVALLTFRELLQSLLALQKLKDDNNARALFDMLLNNVCYVLEYRETVLHLLMNYNEAHSTKVFLRDVVETANVFIKMME-------RFCQDSVVVQDKKRGRGASRKKKQAATKSKPPAAPQPTEEELSSKWAELATEVCSLLSTELEMPEDEQPLPFDA----------ASEKSIDDQREDCMIRINKLLRSEKLDQAIALLRAAREVWPENEVFGAIS--AAPEDELLLLREIFMSNITTVESEDKENEKDQKQDEYEDEDDDLDNEEYEEQDN-GLTEKTFKFDDFARRLLNPKIVRACTLVLSDWADIPTRSLKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQVFS--VERDVHQEELRRLAIFVVRKFVEVAPTNPKIYAELLFYKGIREANELESGYCDAYEAGTKGAWTEEQESELRFLFEENQRN---PETDKDVIDWILDNLVDKTRNRRTVLKKLKELGLLFKAPTKRSTKSAQSGKNVWQPEEDDELRSLYDQHRIEPDCLERLVNEFA-------ERRSKQQIIKRMLQIHL 946
BLAST of Timeless circadian clock vs. Ensembl Fly
Match: tim (gene:FBgn0014396 transcript:FBtr0333253) HSP 1 Score: 56.6102 bits (135), Expect = 1.803e-7 Identity = 48/217 (22.12%), Postives = 105/217 (48.39%), Query Frame = 1
Query: 976 RDRKLRRKAKNQVHNKEETYIHKSTDK-VLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYID----NSKTKESAVSSY-RKLHLVMSAYKELLEFCLMLD--NHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFG 1602
R +KL +++K+ + N + H TD + N L+EF FL GY+ L++ L D +++ W + +F++ + +L E + +T V ++ + + + N++ + S + Y R++HLV++A +E L+ + H E + ++ ++ S+ ++ +LL F P S+ +L+ L+ + +++ IL + G
Sbjct: 553 RRKKLVKRSKSSLINMKGLVQHTPTDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKFAAQLELDMEHIDTILTYDVLSYLTYEGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTYNKVTHLNEDDKAHLRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDSSAKLG 769
BLAST of Timeless circadian clock vs. Ensembl Fly
Match: tim (gene:FBgn0014396 transcript:FBtr0333259) HSP 1 Score: 56.6102 bits (135), Expect = 1.805e-7 Identity = 48/217 (22.12%), Postives = 105/217 (48.39%), Query Frame = 1
Query: 976 RDRKLRRKAKNQVHNKEETYIHKSTDK-VLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYID----NSKTKESAVSSY-RKLHLVMSAYKELLEFCLMLD--NHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFG 1602
R +KL +++K+ + N + H TD + N L+EF FL GY+ L++ L D +++ W + +F++ + +L E + +T V ++ + + + N++ + S + Y R++HLV++A +E L+ + H E + ++ ++ S+ ++ +LL F P S+ +L+ L+ + +++ IL + G
Sbjct: 521 RRKKLVKRSKSSLINMKGLVQHTPTDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKFAAQLELDMEHIDTILTYDVLSYLTYEGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTYNKVTHLNEDDKAHLRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDSSAKLG 737
BLAST of Timeless circadian clock vs. Ensembl Fly
Match: tim (gene:FBgn0014396 transcript:FBtr0333255) HSP 1 Score: 56.6102 bits (135), Expect = 1.815e-7 Identity = 48/217 (22.12%), Postives = 105/217 (48.39%), Query Frame = 1
Query: 976 RDRKLRRKAKNQVHNKEETYIHKSTDK-VLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYID----NSKTKESAVSSY-RKLHLVMSAYKELLEFCLMLD--NHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFG 1602
R +KL +++K+ + N + H TD + N L+EF FL GY+ L++ L D +++ W + +F++ + +L E + +T V ++ + + + N++ + S + Y R++HLV++A +E L+ + H E + ++ ++ S+ ++ +LL F P S+ +L+ L+ + +++ IL + G
Sbjct: 553 RRKKLVKRSKSSLINMKGLVQHTPTDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKFAAQLELDMEHIDTILTYDVLSYLTYEGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTYNKVTHLNEDDKAHLRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDSSAKLG 769
BLAST of Timeless circadian clock vs. Ensembl Fly
Match: tim (gene:FBgn0014396 transcript:FBtr0077567) HSP 1 Score: 56.6102 bits (135), Expect = 2.055e-7 Identity = 48/217 (22.12%), Postives = 105/217 (48.39%), Query Frame = 1
Query: 976 RDRKLRRKAKNQVHNKEETYIHKSTDK-VLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYID----NSKTKESAVSSY-RKLHLVMSAYKELLEFCLMLD--NHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFG 1602
R +KL +++K+ + N + H TD + N L+EF FL GY+ L++ L D +++ W + +F++ + +L E + +T V ++ + + + N++ + S + Y R++HLV++A +E L+ + H E + ++ ++ S+ ++ +LL F P S+ +L+ L+ + +++ IL + G
Sbjct: 553 RRKKLVKRSKSSLINMKGLVQHTPTDDDISNLLKEFTVDFLLKGYSYLVEELHMQLLSNAKVPIDTSHFFWLVTYFLKFAAQLELDMEHIDTILTYDVLSYLTYEGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTYNKVTHLNEDDKAHLRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDSSAKLG 769
BLAST of Timeless circadian clock vs. Ensembl Zebrafish
Match: timeless (timeless circadian clock [Source:ZFIN;Acc:ZDB-GENE-030131-8978]) HSP 1 Score: 329.331 bits (843), Expect = 3.177e-93 Identity = 307/989 (31.04%), Postives = 506/989 (51.16%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQLRRQRELELMAK--SAE--------NPRVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKESAVSSY-RKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFS--DKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E + K+ D + S++D++R+LR E + +IR +LG ++++N L+ ++ + D LFD IRL++NLTQP+ +CF + +P D F++V LQ K F D VLS + ++ +WE R E+++LL+ERIL+L+RN+LH+ + + + S HD L+ + SG DLL +L+ A++E++++FH LEIISLMFR+Q+AE L S+ SA ++Q + +ELEL+ + +AE R RF G++ ++ +K+ +YH + N+ + +RR K + K+ +S V L+EFC FL+ YN LM L R++ Q DETYY+WAL FFM R P+ VSETI+I FH++ + Y + T +S +S+ R++HL + AY+ELL +D ++E R S+ IKS +FY E+ EI+ LL + Q R+FLR L+E + L +++L+ +F K + + K + +Q ME +E L W + E L ++ +LP +L + +P S P V+ Q AL +Q L R EA+++ + +WPE D + EEE+++LK I+F KL + + VEE++ + ++E++ SV V E F+F FI+ F HPN+V + +L N P TN+ + R++H +A K +LYQL +F+ FNK L DP + + + N K +E+LF KN+ E GY+ + + K+ EEE +H+D G V+E+ ++TRR++++ LV++GL+ S K+LK +K+ WT +++ L L E+ +D + I+ + A RSR ++ KIL +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLEGDVYHKEPDCLESVKDLIRYLRHEDDARDIRQQLGAGQILQNDLLPIITQHTQDKPLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQVTSYLQAYKEAFADEKVFTVLSETLYNLLQLDWEQRDEEDNLLIERILLLVRNVLHVPADPYEEKNVDDDASVHDKLLWAIHISGLDDLLKFLACAQSEQQWSFHILEIISLMFRDQTAEL---LVSAGQMRSAQEKQ-KDMQELELLRQKETAEKRSRTLMRGTRHSRFRGSYVIEGLKSIGENDVVYHQGLHNFKSYSHDLGKAVRRVPKRKQMAKDSDSHRRSALNVRLFLREFCIDFLENCYNRLMYLVKEGLIRERAQQHDETYYMWALTFFMAFNRLQNFKPDVVSETISIRTFHFIEKNITNYYEMMLTDKSDATSWSRRMHLALKAYQELLLTVNEMDRSKDENIRHSSSVIKSNIFYLMEFREIFLTLLRKYDERLQPRSFLRDLVESAHLFLRMLE-------RFC-KGRNNLVVQKKRVKRKKRSQKKPEMETSAED------LEQSWQIVSEELRAS---GFQLPESLT---EGAVPFDAASDTP----VNEQRTEALVRIQDCLMSRAGPEALSLLRAARAVWPEGD--TFGSVEVEPEEELELLKQILFT----------KLPRTVPLDSAVEEEDGDELVEEEELESVAVSETEFNFLDFIKRFAHPNIVRPYVILLRSYSQNSPHTNHCVTRMLHRLAVDLKMEALLYQLSVFSLFNKILGDPAAAAYQELVKFAKYVLNRFFVFAATNN--KAFVELLFWKNVGAVREMTEGYTKDGEGSKKKSKWTPEEEAELQRLYEEHKD--SGV--PDVVETLLPLLSSSRTRREVVSHLVSMGLVDSVKDLKKEKKGTRIVLWTEEQEQELQGLFEDFQDSDDVLGNILKRITAK-------RSRARIVDKILSMGLVSDRKEL 935
BLAST of Timeless circadian clock vs. Ensembl Zebrafish
Match: timeless (timeless circadian clock [Source:ZFIN;Acc:ZDB-GENE-030131-8978]) HSP 1 Score: 329.331 bits (843), Expect = 3.212e-93 Identity = 307/989 (31.04%), Postives = 506/989 (51.16%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQLRRQRELELMAK--SAE--------NPRVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKESAVSSY-RKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFS--DKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E + K+ D + S++D++R+LR E + +IR +LG ++++N L+ ++ + D LFD IRL++NLTQP+ +CF + +P D F++V LQ K F D VLS + ++ +WE R E+++LL+ERIL+L+RN+LH+ + + + S HD L+ + SG DLL +L+ A++E++++FH LEIISLMFR+Q+AE L S+ SA ++Q + +ELEL+ + +AE R RF G++ ++ +K+ +YH + N+ + +RR K + K+ +S V L+EFC FL+ YN LM L R++ Q DETYY+WAL FFM R P+ VSETI+I FH++ + Y + T +S +S+ R++HL + AY+ELL +D ++E R S+ IKS +FY E+ EI+ LL + Q R+FLR L+E + L +++L+ +F K + + K + +Q ME +E L W + E L ++ +LP +L + +P S P V+ Q AL +Q L R EA+++ + +WPE D + EEE+++LK I+F KL + + VEE++ + ++E++ SV V E F+F FI+ F HPN+V + +L N P TN+ + R++H +A K +LYQL +F+ FNK L DP + + + N K +E+LF KN+ E GY+ + + K+ EEE +H+D G V+E+ ++TRR++++ LV++GL+ S K+LK +K+ WT +++ L L E+ +D + I+ + A RSR ++ KIL +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLEGDVYHKEPDCLESVKDLIRYLRHEDDARDIRQQLGAGQILQNDLLPIITQHTQDKPLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQVTSYLQAYKEAFADEKVFTVLSETLYNLLQLDWEQRDEEDNLLIERILLLVRNVLHVPADPYEEKNVDDDASVHDKLLWAIHISGLDDLLKFLACAQSEQQWSFHILEIISLMFRDQTAEL---LVSAGQMRSAQEKQ-KDMQELELLRQKETAEKRSRTLMRGTRHSRFRGSYVIEGLKSIGENDVVYHQGLHNFKSYSHDLGKAVRRVPKRKQMAKDSDSHRRSALNVRLFLREFCIDFLENCYNRLMYLVKEGLIRERAQQHDETYYMWALTFFMAFNRLQNFKPDVVSETISIRTFHFIEKNITNYYEMMLTDKSDATSWSRRMHLALKAYQELLLTVNEMDRSKDENIRHSSSVIKSNIFYLMEFREIFLTLLRKYDERLQPRSFLRDLVESAHLFLRMLE-------RFC-KGRNNLVVQKKRVKRKKRSQKKPEMETSAED------LEQSWQIVSEELRAS---GFQLPESLT---EGAVPFDAASDTP----VNEQRTEALVRIQDCLMSRAGPEALSLLRAARAVWPEGD--TFGSVEVEPEEELELLKQILFT----------KLPRTVPLDSAVEEEDGDELVEEEELESVAVSETEFNFLDFIKRFAHPNIVRPYVILLRSYSQNSPHTNHCVTRMLHRLAVDLKMEALLYQLSVFSLFNKILGDPAAAAYQELVKFAKYVLNRFFVFAATNN--KAFVELLFWKNVGAVREMTEGYTKDGEGSKKKSKWTPEEEAELQRLYEEHKD--SGV--PDVVETLLPLLSSSRTRREVVSHLVSMGLVDSVKDLKKEKKGTRIVLWTEEQEQELQGLFEDFQDSDDVLGNILKRITAK-------RSRARIVDKILSMGLVSDRKEL 935
BLAST of Timeless circadian clock vs. Ensembl Zebrafish
Match: timeless (timeless circadian clock [Source:ZFIN;Acc:ZDB-GENE-030131-8978]) HSP 1 Score: 328.561 bits (841), Expect = 9.156e-93 Identity = 307/989 (31.04%), Postives = 506/989 (51.16%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQLRRQRELELMAK--SAE--------NPRVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKESAVSSY-RKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFS--DKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E + K+ D + S++D++R+LR E + +IR +LG ++++N L+ ++ + D LFD IRL++NLTQP+ +CF + +P D F++V LQ K F D VLS + ++ +WE R E+++LL+ERIL+L+RN+LH+ + + + S HD L+ + SG DLL +L+ A++E++++FH LEIISLMFR+Q+AE L S+ SA ++Q + +ELEL+ + +AE R RF G++ ++ +K+ +YH + N+ + +RR K + K+ +S V L+EFC FL+ YN LM L R++ Q DETYY+WAL FFM R P+ VSETI+I FH++ + Y + T +S +S+ R++HL + AY+ELL +D ++E R S+ IKS +FY E+ EI+ LL + Q R+FLR L+E + L +++L+ +F K + + K + +Q ME +E L W + E L ++ +LP +L + +P S P V+ Q AL +Q L R EA+++ + +WPE D + EEE+++LK I+F KL + + VEE++ + ++E++ SV V E F+F FI+ F HPN+V + +L N P TN+ + R++H +A K +LYQL +F+ FNK L DP + + + N K +E+LF KN+ E GY+ + + K+ EEE +H+D G V+E+ ++TRR++++ LV++GL+ S K+LK +K+ WT +++ L L E+ +D + I+ + A RSR ++ KIL +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLEGDVYHKEPDCLESVKDLIRYLRHEDDARDIRQQLGAGQILQNDLLPIITQHTQDKPLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQVTSYLQAYKEAFADEKVFTVLSETLYNLLQLDWEQRDEEDNLLIERILLLVRNVLHVPADPYEEKNVDDDASVHDKLLWAIHISGLDDLLKFLACAQSEQQWSFHILEIISLMFRDQTAEL---LVSAGQMRSAQEKQ-KDMQELELLRQKETAEKRSRTLMRGTRHSRFRGSYVIEGLKSIGENDVVYHQGLHNFKSYSHDLGKAVRRVPKRKQMAKDSDSHRRSALNVRLFLREFCIDFLENCYNRLMYLVKEGLIRERAQQHDETYYMWALTFFMAFNRLQNFKPDVVSETISIRTFHFIEKNITNYYEMMLTDKSDATSWSRRMHLALKAYQELLLTVNEMDRSKDENIRHSSSVIKSNIFYLMEFREIFLTLLRKYDERLQPRSFLRDLVESAHLFLRMLE-------RFC-KGRNNLVVQKKRVKRKKRSQKKPEMETSAED------LEQSWQIVSEELRAS---GFQLPESLT---EGAVPFDAASDTP----VNEQRTEALVRIQDCLMSRAGPEALSLLRAARAVWPEGD--TFGSVEVEPEEELELLKQILFT----------KLPRTVPLDSAVEEEDGDELVEEEELESVAVSETEFNFLDFIKRFAHPNIVRPYVILLRSYSQNSPHTNHCVTRMLHRLAVDLKMEALLYQLSVFSLFNKILGDPAAAAYQELVKFAKYVLNRFFVFAATNN--KAFVELLFWKNVGAVREMTEGYTKDGEGSKKKSKWTPEEEAELQRLYEEHKD--SGV--PDVVETLLPLLSSSRTRREVVSHLVSMGLVDSVKDLKKEKKGTRIVLWTEEQEQELQGLFEDFQDSDDVLGNILKRITAK-------RSRARIVDKILSMGLVSDRKEL 935
BLAST of Timeless circadian clock vs. Ensembl Zebrafish
Match: timeless (timeless circadian clock [Source:ZFIN;Acc:ZDB-GENE-030131-8978]) HSP 1 Score: 328.561 bits (841), Expect = 1.057e-92 Identity = 307/989 (31.04%), Postives = 506/989 (51.16%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQLRRQRELELMAK--SAE--------NPRVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKESAVSSY-RKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFS--DKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E + K+ D + S++D++R+LR E + +IR +LG ++++N L+ ++ + D LFD IRL++NLTQP+ +CF + +P D F++V LQ K F D VLS + ++ +WE R E+++LL+ERIL+L+RN+LH+ + + + S HD L+ + SG DLL +L+ A++E++++FH LEIISLMFR+Q+AE L S+ SA ++Q + +ELEL+ + +AE R RF G++ ++ +K+ +YH + N+ + +RR K + K+ +S V L+EFC FL+ YN LM L R++ Q DETYY+WAL FFM R P+ VSETI+I FH++ + Y + T +S +S+ R++HL + AY+ELL +D ++E R S+ IKS +FY E+ EI+ LL + Q R+FLR L+E + L +++L+ +F K + + K + +Q ME +E L W + E L ++ +LP +L + +P S P V+ Q AL +Q L R EA+++ + +WPE D + EEE+++LK I+F KL + + VEE++ + ++E++ SV V E F+F FI+ F HPN+V + +L N P TN+ + R++H +A K +LYQL +F+ FNK L DP + + + N K +E+LF KN+ E GY+ + + K+ EEE +H+D G V+E+ ++TRR++++ LV++GL+ S K+LK +K+ WT +++ L L E+ +D + I+ + A RSR ++ KIL +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLEGDVYHKEPDCLESVKDLIRYLRHEDDARDIRQQLGAGQILQNDLLPIITQHTQDKPLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQVTSYLQAYKEAFADEKVFTVLSETLYNLLQLDWEQRDEEDNLLIERILLLVRNVLHVPADPYEEKNVDDDASVHDKLLWAIHISGLDDLLKFLACAQSEQQWSFHILEIISLMFRDQTAEL---LVSAGQMRSAQEKQ-KDMQELELLRQKETAEKRSRTLMRGTRHSRFRGSYVIEGLKSIGENDVVYHQGLHNFKSYSHDLGKAVRRVPKRKQMAKDSDSHRRSALNVRLFLREFCIDFLENCYNRLMYLVKEGLIRERAQQHDETYYMWALTFFMAFNRLQNFKPDVVSETISIRTFHFIEKNITNYYEMMLTDKSDATSWSRRMHLALKAYQELLLTVNEMDRSKDENIRHSSSVIKSNIFYLMEFREIFLTLLRKYDERLQPRSFLRDLVESAHLFLRMLE-------RFC-KGRNNLVVQKKRVKRKKRSQKKPEMETSAED------LEQSWQIVSEELRAS---GFQLPESLT---EGAVPFDAASDTP----VNEQRTEALVRIQDCLMSRAGPEALSLLRAARAVWPEGD--TFGSVEVEPEEELELLKQILFT----------KLPRTVPLDSAVEEEDGDELVEEEELESVAVSETEFNFLDFIKRFAHPNIVRPYVILLRSYSQNSPHTNHCVTRMLHRLAVDLKMEALLYQLSVFSLFNKILGDPAAAAYQELVKFAKYVLNRFFVFAATNN--KAFVELLFWKNVGAVREMTEGYTKDGEGSKKKSKWTPEEEAELQRLYEEHKD--SGV--PDVVETLLPLLSSSRTRREVVSHLVSMGLVDSVKDLKKEKKGTRIVLWTEEQEQELQGLFEDFQDSDDVLGNILKRITAK-------RSRARIVDKILSMGLVSDRKEL 935
BLAST of Timeless circadian clock vs. Ensembl Xenopus
Match: hsph1 (heat shock protein family H (Hsp110) member 1 [Source:Xenbase;Acc:XB-GENE-965196]) HSP 1 Score: 338.576 bits (867), Expect = 6.117e-96 Identity = 321/991 (32.39%), Postives = 516/991 (52.07%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNST-ESASD---QQLRRQRELELMAKSA--ENPRVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSA-VNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGY-----SNSDDNNPK-EWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E+ + K+ D + S++D++R+LR E + +IR +LG ++++N LI L+ ++ND LFD VIRL++N+TQP+ +CF + +P+D F++V LQ K F + VLS K+ D+ EWE R E+ +LL+ERIL+L+RNILH+ + + + S HD ++ + SG DL+ +L+++E E++++ H LE +SLMFR+Q AE + + ST E +D ++ RQRE A R RFGG++ +Q +K+ + IYH I N+ +++RR K + KE +S V L+EFC FL+ YN LM L R++ Q DETYYLW++ FFM R + PE VSET++I FH++ Q Y + T K+ A S R++HL + AY+ELL +D+ +EE R S IK+ +FY EY E++ L F KQ R+FL+ L+E + L +K+L+ KF K +K + +++ G E+ Q L IW + E L + VN E NLP D ++P + SE PV+ Q AL +Q L + EA+ + +++WPE D + EEE ++LK I+FA +L + ++ +E V+ E+E E E ++E++ SVQV E F+F +++ F + NVV T+ +L ++ N TN+ + +++H IA K +L+QL +F FNK L DP ++ + I N K +E+LF KN + E GY S+ N + +WT E E+EL RL+ + + + D I + +TR+Q++N LV +GL S K+ K + + WT D++ L L E+ +D + IM + A RS+ +I+K++ +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLESDTYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAAQILQNDLIPLVIQHHNDKQLFDAVIRLMVNVTQPALLCFGK-VPQDPTFRHHFLQVVSYLQAYKEAFANERLFGVLSEKLYDLLQMEWEQREEEHNLLIERILLLVRNILHVPPDPEEEKSVDDDASIHDRVLWAIHMSGMDDLIKFLASSETEQQWSMHVLETVSLMFRDQIAEHLAATGQARSTAERDTDIKNLEILRQRESAEKKNRALQRGTRHSRFGGSYIVQGLKSIGDKDVIYHKGIHNFKNYTHDLGKEVRRVPKRKQQAKETEARRRSALNVRLFLKEFCIDFLENCYNRLMYIVKDNLIREKAQQHDETYYLWSMAFFMGFNRLFRFQPELVSETVSIRTFHFIEQNLTNYYEMMLTDKKEATSWARRMHLALKAYQELLSTVHEMDHSKEEAVRESSKIIKNNIFYLMEYRELFLALFRKFDETKQPRSFLKDLVETTHLFLKMLE-------KFCKGKQTVVVQKRRVKRKKKKSSVSGAKEV---QPKSTEELAAIWTNVSEQLTTCIVNSE-----NLP---DSVVP-----FDAASEIPVEEQRAEALVRIQDGLFSGCAAEALVLLRSAREVWPEGDVFGAA--EIEPEEETELLKQILFA-------ELPRSTQ--AESEVLGEEEEEDEIEEEELTSVQVSEREFNFLDYMKRFANSNVVKTYVLLLKNYQQNSAHTNHCVAKMLHRIAYDLKMEALLFQLSVFCIFNKILGDPAASAYKELVAFSKYILNKFFSL--AATNNKAYVELLFWKNTNVIREMTEGYRKLGEEESEANRKRIKWTPEDEDELRRLYLQFKE---IEDADVVDNIVANLKPGTRTRKQVINHLVQMGLADSVKDFKQETKGTRIVLWTEDQELELQRLYEDFKDSDDILGNIMKNVTAK-------RSKARIIEKLISMGLVCDRKEL 944
BLAST of Timeless circadian clock vs. Ensembl Xenopus
Match: hsph1 (heat shock protein family H (Hsp110) member 1 [Source:Xenbase;Acc:XB-GENE-965196]) HSP 1 Score: 332.798 bits (852), Expect = 7.832e-95 Identity = 311/992 (31.35%), Postives = 505/992 (50.91%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNST-ESASD---QQLRRQRELELMAKSA--ENPRVKRFGGTFELQDIKTESGRPAIYHHDINWSKIDLTRD--RKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGY-----SNSDDNNPK-EWT-DXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E+ + K+ D + S++D++R+LR E + +IR +LG ++++N LI L+ ++ND LFD VIRL++N+TQP+ +CF + +P+D F++V LQ K F + VLS K+ D+ EWE R E+ +LL+ERIL+L+RNILH+ + + + S HD ++ + SG DL+ +L+++E E++++ H LE +SLMFR+Q AE + + ST E +D ++ RQRE A R RFGG++ +Q +K+ + IYH I+ K + T D +++RR K + KE +S V L+EFC FL+ YN LM L R++ Q DETYYLW++ FFM R + PE VSET++I FH++ Q Y + T K+ A S R++HL + AY+ELL +D+ +EE R S IK+ +FY EY E++ L F KQ R+FL+ L+E + L +K+L+ KF + + +++ EQ + + L S N E NLP D ++P + SE PV+ Q AL +Q L + EA+ + +++WPE D + + EEE ++LK I+FA E+ V+ E+E E E ++E++ SVQV E F+F +++ F + NVV T+ +L ++ N TN+ + +++H IA K +L+QL +F FNK L DP ++ + I N K +E+LF KN + E GY S+ N + +WT ++ +E + + ED++ I + +TR+Q++N LV +GL S K+ K + + WT D++ L L E+ +D + IM + A RS+ +I+K++ +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLESDTYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAAQILQNDLIPLVIQHHNDKQLFDAVIRLMVNVTQPALLCFGK-VPQDPTFRHHFLQVVSYLQAYKEAFANERLFGVLSEKLYDLLQMEWEQREEEHNLLIERILLLVRNILHVPPDPEEEKSVDDDASIHDRVLWAIHMSGMDDLIKFLASSETEQQWSMHVLETVSLMFRDQIAEHLAATGQARSTAERDTDIKNLEILRQRESAEKKNRALQRGTRHSRFGGSYIVQGLKSIGDKDVIYHKGIHNFK-NYTHDLGKEVRRVPKRKQQAKETEARRRSALNVRLFLKEFCIDFLENCYNRLMYIVKDNLIREKAQQHDETYYLWSMAFFMGFNRLFRFQPELVSETVSIRTFHFIEQNLTNYYEMMLTDKKEATSWARRMHLALKAYQELLSTVHEMDHSKEEAVRESSKIIKNNIFYLMEYRELFLALFRKFDETKQPRSFLKDLVETTHLFLKMLE-------KFC------------------KGKQTVVVQVREEQAINLLFQISVSNHNLHLFKSTQNSE-----NLP---DSVVP-----FDAASEIPVEEQRAEALVRIQDGLFSGCAAEALVLLRSAREVWPEGD--VFGAAEIEPEEETELLKQILFA--------------ELPSKSVLGEEEEEDEIEEEELTSVQVSEREFNFLDYMKRFANSNVVKTYVLLLKNYQQNSAHTNHCVAKMLHRIAYDLKMEALLFQLSVFCIFNKILGDPAASAYKELVAFSKYILNKFFSLAATNN--KAYVELLFWKNTNVIREMTEGYRKLGEEESEANRKRIKWTPEDEDELRRLYLQFKEIEDVVDN------IVANLKPGTRTRKQVINHLVQMGLADSVKDFKQETKGTRIVLWTEDQELELQRLYEDFKDSDDILGNIMKNVTAK-------RSKARIIEKLISMGLVCDRKEL 921
BLAST of Timeless circadian clock vs. Ensembl Xenopus
Match: hsph1 (heat shock protein family H (Hsp110) member 1 [Source:Xenbase;Acc:XB-GENE-965196]) HSP 1 Score: 320.857 bits (821), Expect = 4.719e-91 Identity = 309/983 (31.43%), Postives = 490/983 (49.85%), Query Frame = 1
Query: 88 DLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNST-ESASD---QQLRRQRELELMAKSA--ENPRVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSA-VNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGY-----SNSDDNNPK-EWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
+L A + LG E+ + K+ D + S++D++R+LR E + +IR +LG ++++N LI L+ ++ND LFD VIRL++N+TQP+ +CF + +P+D F++V LQ K F + VLS K+ D+ EWE R E+ +LL+ERIL+L+RNILH+ + + + S HD ++ + SG DL+ +L+++E E++++ H LE +SLMFR+Q AE + + ST E +D ++ RQRE A R RFGG++ +Q +K+ + IYH I N S +++RR K + KE +S V L+EFC FL+ YN LM L R++ Q DETYYLW++ FFM R + PE VSET++I FH++ Q Y + T K+ A S R++HL + AY+ELL +D+ +EE R S IK+ +FY EY E++ L F KQ R+FL+ L+E + L +K+L+ KF K +K + +++ G E+ Q L IW + E L + VN E NLP D ++P + SE PV+ Q AL +Q L + EA+ + +++WPE D + + EEE ++LK I+FA K I++ QV F + NVV T+ +L ++ N TN+ + +++H IA K +L+QL +F FNK L DP ++ + I N K +E+LF KN + E GY S+ N + +WT E E+EL RL+ + + + D I + +TR+Q++N LV +GL S K+ K + + WT D++ L L E+ +D + IM + A RS+ +I+K++ +GLV ++ +L
Sbjct: 5 ELLATCSALGYLESDTYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAAQILQNDLIPLVIQHHNDKQLFDAVIRLMVNVTQPALLCFGK-VPQDPTFRHHFLQVVSYLQAYKEAFANERLFGVLSEKLYDLLQMEWEQREEEHNLLIERILLLVRNILHVPPDPEEEKSVDDDASIHDRVLWAIHMSGMDDLIKFLASSETEQQWSMHVLETVSLMFRDQIAEHLAATGQARSTAERDTDIKNLEILRQRESAEKKNRALQRGTRHSRFGGSYIVQGLKSIGDKDVIYHKGIHNVSNYTHDLGKEVRRVPKRKQQAKETEARRRSALNVRLFLKEFCIDFLENCYNRLMYIVKDNLIREKAQQHDETYYLWSMAFFMGFNRLFRFQPELVSETVSIRTFHFIEQNLTNYYEMMLTDKKEATSWARRMHLALKAYQELLSTVHEMDHSKEEAVRESSKIIKNNIFYLMEYRELFLALFRKFDETKQPRSFLKDLVETTHLFLKMLE-------KFCKGKQTVVVQKRRVKRKKKKSSVSGAKEV---QPKSTEELAAIWTNVSEQLTTCIVNSE-----NLP---DSVVP-----FDAASEIPVEEQRAEALVRIQDGLFSGCAAEALVLLRSAREVWPEGD--VFGAAEIEPEEETELLKQILFAELPSK----------------------------SAISAYQV-------------FANSNVVKTYVLLLKNYQQNSAHTNHCVAKMLHRIAYDLKMEALLFQLSVFCIFNKILGDPAASAYKELVAFSKYILNKFFSL--AATNNKAYVELLFWKNTNVIREMTEGYRKLGEEESEANRKRIKWTPEDEDELRRLYLQFKE---IEDADVVDNIVANLKPGTRTRKQVINHLVQMGLADSVKDFKQETKGTRIVLWTEDQELELQRLYEDFKDSDDILGNIMKNVTAK-------RSKARIIEKLISMGLVCDRKEL 908
BLAST of Timeless circadian clock vs. Ensembl Xenopus
Match: hsph1 (heat shock protein family H (Hsp110) member 1 [Source:Xenbase;Acc:XB-GENE-965196]) HSP 1 Score: 319.701 bits (818), Expect = 2.578e-90 Identity = 316/992 (31.85%), Postives = 505/992 (50.91%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNST-ESASD---QQLRRQRELELMAKSA--ENPRVKRFGGTFELQDIKTESGRPAIYHHDINWSKIDLTRD--RKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSA-VNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGY-----SNSDDNNPK-EWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E+ + K+ D + S++D++R+LR E + +IR +LG ++++N LI L+ ++ND LFD VIRL++N+TQP+ +CF + +P+D F++V LQ K F + VLS K+ D+ EWE R E+ +LL+ERIL+L+RNILH+ + + + S HD ++ + SG DL+ +L+++E E++++ H LE +SLMFR+Q AE + + ST E +D ++ RQRE A R RFGG++ +Q +K+ + IYH I+ K + T D +++RR K + KE +S V L+EFC FL+ YN LM L R++ Q DETYYLW++ FFM R + PE VSET++I FH++ Q Y + T K+ A S R++HL + AY+ELL +D+ +EE R S IK+ +FY EY E++ L F KQ R+FL+ L+E + L +K+L+ KF K +K + +++ G E+ Q L IW + E L + VN E NLP D ++P + SE PV+ Q RA LV+I+ + + +V++ I LK+ N Y L +E V+ E+E E E ++E++ SVQV E F+F +++ F + NVV T+ +L ++ N TN+ + +++H IA K +L+QL +F FNK L DP ++ + I N K +E+LF KN + E GY S+ N + +WT E E+EL RL+ + + + D I + +TR+Q++N LV +GL S K+ K + + WT D++ L L E+ +D + IM + A RS+ +I+K++ +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLESDTYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAAQILQNDLIPLVIQHHNDKQLFDAVIRLMVNVTQPALLCFGK-VPQDPTFRHHFLQVVSYLQAYKEAFANERLFGVLSEKLYDLLQMEWEQREEEHNLLIERILLLVRNILHVPPDPEEEKSVDDDASIHDRVLWAIHMSGMDDLIKFLASSETEQQWSMHVLETVSLMFRDQIAEHLAATGQARSTAERDTDIKNLEILRQRESAEKKNRALQRGTRHSRFGGSYIVQGLKSIGDKDVIYHKGIHNFK-NYTHDLGKEVRRVPKRKQQAKETEARRRSALNVRLFLKEFCIDFLENCYNRLMYIVKDNLIREKAQQHDETYYLWSMAFFMGFNRLFRFQPELVSETVSIRTFHFIEQNLTNYYEMMLTDKKEATSWARRMHLALKAYQELLSTVHEMDHSKEEAVRESSKIIKNNIFYLMEYRELFLALFRKFDETKQPRSFLKDLVETTHLFLKMLE-------KFCKGKQTVVVQKRRVKRKKKKSSVSGAKEV---QPKSTEELAAIWTNVSEQLTTCIVNSE-----NLP---DSVVP-----FDAASEIPVEEQ--RAEALVRIQDGLFSGLLSVSL------------------------SAIFFLKNTCLPNLNYSH-----LGSTQAESEVLGEEEEEDEIEEEELTSVQVSEREFNFLDYMKRFANSNVVKTYVLLLKNYQQNSAHTNHCVAKMLHRIAYDLKMEALLFQLSVFCIFNKILGDPAASAYKELVAFSKYILNKFFSL--AATNNKAYVELLFWKNTNVIREMTEGYRKLGEEESEANRKRIKWTPEDEDELRRLYLQFKE---IEDADVVDNIVANLKPGTRTRKQVINHLVQMGLADSVKDFKQETKGTRIVLWTEDQELELQRLYEDFKDSDDILGNIMKNVTAK-------RSKARIIEKLISMGLVCDRKEL 924
BLAST of Timeless circadian clock vs. Ensembl Xenopus
Match: hsph1 (heat shock protein family H (Hsp110) member 1 [Source:Xenbase;Acc:XB-GENE-965196]) HSP 1 Score: 304.294 bits (778), Expect = 3.149e-85 Identity = 292/913 (31.98%), Postives = 474/913 (51.92%), Query Frame = 1
Query: 88 DLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNST-ESASD---QQLRRQRELELMAKSA--ENPRVKRFGGTFELQDIKTESGRPAIYHHDINWSKIDLTRD--RKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWT---------DXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKEL 2769
+L A + LG E+ + K+ D + S++D++R+LR E + +IR +LG ++++N LI L+ ++ND LFD VIRL++N+TQP+ +CF + +P+D F++V LQ K F + VLS K+ D+ EWE R E+ +LL+ERIL+L+RNILH+ + + + S HD ++ + SG DL+ +L+++E E++++ H LE +SLMFR+Q AE + + ST E +D ++ RQRE A R RFGG++ +Q +K+ + IYH I+ K + T D +++RR K + KE +S V L+EFC FL+ YN LM L R++ Q DETYYLW++ FFM R + PE VSET++I FH++ Q Y + T K+ A S R++HL + AY+ELL +D+ +EE R S IK+ +FY EY E++ L F KQ R+FL+ L+E + L +K+L+ KF K +K + +++ G E+ Q N L S N E NLP D ++P + SE PV+ Q AL +Q L + EA+ + +++WPE D + + EEE ++LK I+FA +L + ++ +E V+ E+E E E ++E++ SVQV E F+F +++ F + NVV T+ +L ++ N TN+ + +++H IA K +L+QL +F FNK L DP ++ + I N K +E+LF KN + E GY + W ++ +E + + EDIL +++++ + ++K R I+ +L+++GL+ KEL
Sbjct: 5 ELLATCSALGYLESDTYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAAQILQNDLIPLVIQHHNDKQLFDAVIRLMVNVTQPALLCFGK-VPQDPTFRHHFLQVVSYLQAYKEAFANERLFGVLSEKLYDLLQMEWEQREEEHNLLIERILLLVRNILHVPPDPEEEKSVDDDASIHDRVLWAIHMSGMDDLIKFLASSETEQQWSMHVLETVSLMFRDQIAEHLAATGQARSTAERDTDIKNLEILRQRESAEKKNRALQRGTRHSRFGGSYIVQGLKSIGDKDVIYHKGIHNFK-NYTHDLGKEVRRVPKRKQQAKETEARRRSALNVRLFLKEFCIDFLENCYNRLMYIVKDNLIREKAQQHDETYYLWSMAFFMGFNRLFRFQPELVSETVSIRTFHFIEQNLTNYYEMMLTDKKEATSWARRMHLALKAYQELLSTVHEMDHSKEEAVRESSKIIKNNIFYLMEYRELFLALFRKFDETKQPRSFLKDLVETTHLFLKMLE-------KFCKGKQTVVVQKRRVKRKKKKSSVSGAKEVQLFQISVSN-------HNLHLFKSTQNSE-----NLP---DSVVP-----FDAASEIPVEEQRAEALVRIQDGLFSGCAAEALVLLRSAREVWPEGD--VFGAAEIEPEEETELLKQILFA-------ELPRSTQ--AESEVLGEEEEEDEIEEEELTSVQVSEREFNFLDYMKRFANSNVVKTYVLLLKNYQQNSAHTNHCVAKMLHRIAYDLKMEALLFQLSVFCIFNKILGDPAASAYKELVAFSKYILNKFFSL--AATNNKAYVELLFWKNTNVIREMTEGYRKLGEEERAGWNLLARIKWTPEDEDELRRLYLQFKEIEDIL-----GNIMKNVTAKRSKAR--IIEKLISMGLVCDRKEL 868
BLAST of Timeless circadian clock vs. Ensembl Mouse
Match: Timeless (timeless circadian clock 1 [Source:MGI Symbol;Acc:MGI:1321393]) HSP 1 Score: 314.309 bits (804), Expect = 2.997e-88 Identity = 310/1011 (30.66%), Postives = 504/1011 (49.85%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFM-----DTLKSSNSTESASDQQLRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNA---LQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRI---MVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGY----SNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP-WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKNSKLIPNYDSG 3030
M+ Y+ + TC LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L + D LFD VIRL++NLTQP+ +CF +PKD F++V LQ K F VLS + ++ WEDR E+++LL+ERIL+L+RNILH+ N + S HD L+ + SG DLL++LS++ E++++ H LEIISLMFR+Q+ E + L ST+ A + LR++ E A++ + R RFGG++ +Q +K+ + ++H H++ DL K R+ + +E +H+ + VLN L++FC FL+ YN LM L R++ Q DETYY+WA+ FFM R P VSET++I FH+V Q Y + T ++ A S R++HL + AY+ELL +D +E R S IK+ +FY EY E++ L F R+FLR L+E + L +K+L E + G +RK K K ++Q + + P E L +W + E L+ + EL + DP++P + SE PV+ Q A+ +Q L + +A+A+ +++WPE + +++ EE+++LK I+ + ++++ + E E E ++E++ VQV E F+F +++ F +V + +L N TN+ + +++H +A +L+QL LF FN+ L DP + + I VN+ K +E+LF KN E GY S S + W+ E E +L L+ H+D+ G D I + +TR+Q+++ LV +GL S KE + +K WT D++ L L EE RD + +IM + A RSR V+ K+L LGLV + QL + + KL P+ +G
Sbjct: 1 MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFG-SVPKDSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQRGNRHSRFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLG---KQPRRVPKRRQAAQELSVHRRS--VLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAATFRPGLVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKML----ERFCRSRGNLMVQNKRKKRKKKKKVQDQGVAFSQSPGE-------LEAMWPALAEQLLQCAQ-DPELSV------DPVVP-----FDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPEGNAFGSPVISPG-----EEMQLLKQIL-STPLPRQQEPEEGDAEEEEE----------EEEEEELQVVQVSEKEFNFLEYLKRFASSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLSLFCLFNRLLSDPAAAAYKELVTFAKYIIGKFFALAAVNQ--KAFVELLFWKNTAVVREMTQGYGSLDSGSSSHRAPLWSPEEEAQLQELYLA--HKDV-EGQDVVETILAHLKVVPRTRKQVIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLFEEFRDSDDVLGQIMKNITAK-------RSRARVVDKLLALGLVSERRQL-YKKRRKKLAPSCMNG 953
BLAST of Timeless circadian clock vs. Ensembl Mouse
Match: Timeless (timeless circadian clock 1 [Source:MGI Symbol;Acc:MGI:1321393]) HSP 1 Score: 312.768 bits (800), Expect = 7.954e-88 Identity = 309/1007 (30.69%), Postives = 502/1007 (49.85%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFM-----DTLKSSNSTESASDQQLRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNA---LQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRI---MVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGY----SNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP-WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKNSKLIPN 3018
M+ Y+ + TC LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L + D LFD VIRL++NLTQP+ +CF +PKD F++V LQ K F VLS + ++ WEDR E+++LL+ERIL+L+RNILH+ N + S HD L+ + SG DLL++LS++ E++++ H LEIISLMFR+Q+ E + L ST+ A + LR++ E A++ + R RFGG++ +Q +K+ + ++H H++ DL K R+ + +E +H+ + VLN L++FC FL+ YN LM L R++ Q DETYY+WA+ FFM R P VSET++I FH+V Q Y + T ++ A S R++HL + AY+ELL +D +E R S IK+ +FY EY E++ L F R+FLR L+E + L +K+L E + G +RK K K ++Q + + P E L +W + E L+ + EL + DP++P + SE PV+ Q A+ +Q L + +A+A+ +++WPE + +++ EE+++LK I+ + ++++ + E E E ++E++ VQV E F+F +++ F +V + +L N TN+ + +++H +A +L+QL LF FN+ L DP + + I VN+ K +E+LF KN E GY S S + W+ E E +L L+ H+D+ G D I + +TR+Q+++ LV +GL S KE + +K WT D++ L L EE RD + +IM + A RSR V+ K+L LGLV + QL + + KL P+
Sbjct: 1 MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFG-SVPKDSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQRGNRHSRFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLG---KQPRRVPKRRQAAQELSVHRRS--VLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAATFRPGLVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKML----ERFCRSRGNLMVQNKRKKRKKKKKVQDQGVAFSQSPGE-------LEAMWPALAEQLLQCAQ-DPELSV------DPVVP-----FDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPEGNAFGSPVISPG-----EEMQLLKQIL-STPLPRQQEPEEGDAEEEEE----------EEEEEELQVVQVSEKEFNFLEYLKRFASSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLSLFCLFNRLLSDPAAAAYKELVTFAKYIIGKFFALAAVNQ--KAFVELLFWKNTAVVREMTQGYGSLDSGSSSHRAPLWSPEEEAQLQELYLA--HKDV-EGQDVVETILAHLKVVPRTRKQVIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLFEEFRDSDDVLGQIMKNITAK-------RSRARVVDKLLALGLVSERRQL-YKKRRKKLAPS 949
BLAST of Timeless circadian clock vs. Ensembl Mouse
Match: Timeless (timeless circadian clock 1 [Source:MGI Symbol;Acc:MGI:1321393]) HSP 1 Score: 312.768 bits (800), Expect = 7.954e-88 Identity = 309/1007 (30.69%), Postives = 502/1007 (49.85%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFM-----DTLKSSNSTESASDQQLRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNA---LQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRI---MVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGY----SNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP-WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKNSKLIPN 3018
M+ Y+ + TC LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L + D LFD VIRL++NLTQP+ +CF +PKD F++V LQ K F VLS + ++ WEDR E+++LL+ERIL+L+RNILH+ N + S HD L+ + SG DLL++LS++ E++++ H LEIISLMFR+Q+ E + L ST+ A + LR++ E A++ + R RFGG++ +Q +K+ + ++H H++ DL K R+ + +E +H+ + VLN L++FC FL+ YN LM L R++ Q DETYY+WA+ FFM R P VSET++I FH+V Q Y + T ++ A S R++HL + AY+ELL +D +E R S IK+ +FY EY E++ L F R+FLR L+E + L +K+L E + G +RK K K ++Q + + P E L +W + E L+ + EL + DP++P + SE PV+ Q A+ +Q L + +A+A+ +++WPE + +++ EE+++LK I+ + ++++ + E E E ++E++ VQV E F+F +++ F +V + +L N TN+ + +++H +A +L+QL LF FN+ L DP + + I VN+ K +E+LF KN E GY S S + W+ E E +L L+ H+D+ G D I + +TR+Q+++ LV +GL S KE + +K WT D++ L L EE RD + +IM + A RSR V+ K+L LGLV + QL + + KL P+
Sbjct: 1 MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFG-SVPKDSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQRGNRHSRFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLG---KQPRRVPKRRQAAQELSVHRRS--VLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAATFRPGLVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKML----ERFCRSRGNLMVQNKRKKRKKKKKVQDQGVAFSQSPGE-------LEAMWPALAEQLLQCAQ-DPELSV------DPVVP-----FDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPEGNAFGSPVISPG-----EEMQLLKQIL-STPLPRQQEPEEGDAEEEEE----------EEEEEELQVVQVSEKEFNFLEYLKRFASSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLSLFCLFNRLLSDPAAAAYKELVTFAKYIIGKFFALAAVNQ--KAFVELLFWKNTAVVREMTQGYGSLDSGSSSHRAPLWSPEEEAQLQELYLA--HKDV-EGQDVVETILAHLKVVPRTRKQVIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLFEEFRDSDDVLGQIMKNITAK-------RSRARVVDKLLALGLVSERRQL-YKKRRKKLAPS 949
BLAST of Timeless circadian clock vs. Ensembl Mouse
Match: Timeless (timeless circadian clock 1 [Source:MGI Symbol;Acc:MGI:1321393]) HSP 1 Score: 312.768 bits (800), Expect = 8.561e-88 Identity = 309/1007 (30.69%), Postives = 502/1007 (49.85%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFM-----DTLKSSNSTESASDQQLRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNA---LQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRI---MVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGY----SNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP-WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKNSKLIPN 3018
M+ Y+ + TC LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L + D LFD VIRL++NLTQP+ +CF +PKD F++V LQ K F VLS + ++ WEDR E+++LL+ERIL+L+RNILH+ N + S HD L+ + SG DLL++LS++ E++++ H LEIISLMFR+Q+ E + L ST+ A + LR++ E A++ + R RFGG++ +Q +K+ + ++H H++ DL K R+ + +E +H+ + VLN L++FC FL+ YN LM L R++ Q DETYY+WA+ FFM R P VSET++I FH+V Q Y + T ++ A S R++HL + AY+ELL +D +E R S IK+ +FY EY E++ L F R+FLR L+E + L +K+L E + G +RK K K ++Q + + P E L +W + E L+ + EL + DP++P + SE PV+ Q A+ +Q L + +A+A+ +++WPE + +++ EE+++LK I+ + ++++ + E E E ++E++ VQV E F+F +++ F +V + +L N TN+ + +++H +A +L+QL LF FN+ L DP + + I VN+ K +E+LF KN E GY S S + W+ E E +L L+ H+D+ G D I + +TR+Q+++ LV +GL S KE + +K WT D++ L L EE RD + +IM + A RSR V+ K+L LGLV + QL + + KL P+
Sbjct: 1 MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFG-SVPKDSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQRGNRHSRFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLG---KQPRRVPKRRQAAQELSVHRRS--VLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAATFRPGLVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKML----ERFCRSRGNLMVQNKRKKRKKKKKVQDQGVAFSQSPGE-------LEAMWPALAEQLLQCAQ-DPELSV------DPVVP-----FDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPEGNAFGSPVISPG-----EEMQLLKQIL-STPLPRQQEPEEGDAEEEEE----------EEEEEELQVVQVSEKEFNFLEYLKRFASSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLSLFCLFNRLLSDPAAAAYKELVTFAKYIIGKFFALAAVNQ--KAFVELLFWKNTAVVREMTQGYGSLDSGSSSHRAPLWSPEEEAQLQELYLA--HKDV-EGQDVVETILAHLKVVPRTRKQVIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLFEEFRDSDDVLGQIMKNITAK-------RSRARVVDKLLALGLVSERRQL-YKKRRKKLAPS 949
BLAST of Timeless circadian clock vs. Ensembl Mouse
Match: Timeless (timeless circadian clock 1 [Source:MGI Symbol;Acc:MGI:1321393]) HSP 1 Score: 236.113 bits (601), Expect = 1.660e-66 Identity = 183/520 (35.19%), Postives = 288/520 (55.38%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFM-----DTLKSSNSTESASDQQLRRQRELELMAKSAE-NPRVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNA---LQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQ 1584
M+ Y+ + TC LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L + D LFD VIRL++NLTQP+ +CF +PKD F++V LQ K F VLS + ++ WEDR E+++LL+ERIL+L+RNILH+ N + S HD L+ + SG DLL++LS++ E++++ H LEIISLMFR+Q+ E + L ST+ A + LR++ E A++ + R RFGG++ +Q +K+ + ++H H++ DL K R+ + +E +H+ + VLN L++FC FL+ YN LM L R++ Q DETYY+WA+ FFM R P VSET++I FH+V Q Y + T ++ A S R++HL + AY+ELL +D +E R S IK+ +FY EY E++ L F R+FLR L+E + L +K+L+
Sbjct: 1 MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFG-SVPKDSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQRGNRHSRFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLG---KQPRRVPKRRQAAQELSVHRRS--VLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAATFRPGLVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKMLE 514
BLAST of Timeless circadian clock vs. UniProt/SwissProt
Match: sp|Q9UNS1|TIM_HUMAN (Protein timeless homolog OS=Homo sapiens OX=9606 GN=TIMELESS PE=1 SV=2) HSP 1 Score: 325.479 bits (833), Expect = 3.924e-91 Identity = 306/996 (30.72%), Postives = 501/996 (50.30%), Query Frame = 1
Query: 88 DLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESAS----DQQLRRQRELELMAKSA--ENPRVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLM-SAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKE----WTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNPWTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKN---SKLIPN 3018
+L A + LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L ++ D LFD VIRL++NLTQP+ +CF LPK+ F++V LQ K F VLS + ++ WE+R E+++LL+ERIL+L+RNILH+ + + S HD L+ + SG DLL++L+++ EE+++ H LEI+SLMFR+Q+ E + + + S + ++ RQRE+ A R RFGG++ +Q +K+ R I+H H++ DL + K + K + +E + +S V L++FC FL+ YN LM + L R++ Q DETYY+WAL FFM R P VSET+++ FH++ Q Y + T ++ A S R++HL + AY+ELL +D +E R S IK+ +FY EY E++ L F Q R+FLR L+E + L +K+L+ F + K++K K K +Q I + +PS ++ + +W + E L A N E+ + D ++P + SE PV+ Q A+ +Q L + +A+ + +++WPE D + D EEEI++LK I+ A + + E G E+E E E ++E++ VQV E F+F +++ F VV + +L N TN+ +++++H +A K +L+QL +F FN+ L DP + + I VN+ K +E+LF KN E GY + DD + W+ E E L L+ ++D+ G D I + + +TR+QI++ LV +GL S K+ + K WT D++ L L EE RD + IM + A RSR ++ K+L LGLV + +L + + S ++PN
Sbjct: 9 ELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHHQDKPLFDAVIRLMVNLTQPALLCFGN-LPKEPSFRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEERQEEDNLLIERILLLVRNILHVPADLDQEKKIDDDASAHDQLLWAIHLSGLDDLLLFLASSSAEEQWSLHVLEIVSLMFRDQNPEQLAGVGQGRLAQERSADFAELEVLRQREMAEKKTRALQRGNRHSRFGGSYIVQGLKSIGERDLIFHKGLHNLRNYSSDLGKQPK--KVPKRRQAARELSIQRRSALNVRLFLRDFCSEFLENCYNRLMGSVKDHLLREKAQQHDETYYMWALAFFMAFNRAASFRPGLVSETLSVRTFHFIEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDISPDEAVRESSRIIKNNIFYVMEYRELFLALFRKFDERCQPRSFLRDLVETTHLFLKMLE---RFCRSRGNLVVQNKQKKRRKKKKKVLDQAIVSGNVPSSPEE----VEAVWPALAEQLQCCAQNSELSM--------DSVVP-----FDAASEVPVEEQRAEAMVRIQDCLLAGQAPQALTLLRSAREVWPEGD--VFGSQDISPEEEIQLLKQILSAP--------LPRQQGPEERGAE-EEEEEEEEEEEELQVVQVSEKEFNFLDYLKRFACSTVVRAYVLLLRSYQQNSAHTNHCIVKMLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGAYKELVTFAKYILGKFFALAAVNQ--KAFVELLFWKNTAVVREMTEGYGSLDDRSSSRRAPTWSPEEEAHLRELYLA--NKDV-EGQDVVEAILAHLNTVPRTRKQIIHHLVQMGLADSVKDFQRKGTHIVLWTGDQELELQRLFEEFRDSDDVLGHIMKNITAK-------RSRARIVDKLLALGLVAERRELYKKRQKKLASSILPN 958
BLAST of Timeless circadian clock vs. UniProt/SwissProt
Match: sp|Q9R1X4|TIM_MOUSE (Protein timeless homolog OS=Mus musculus OX=10090 GN=Timeless PE=1 SV=3) HSP 1 Score: 312.768 bits (800), Expect = 5.564e-87 Identity = 309/1007 (30.69%), Postives = 502/1007 (49.85%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFM-----DTLKSSNSTESASDQQLRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNA---LQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRI---MVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGY----SNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP-WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKNSKLIPN 3018
M+ Y+ + TC LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L + D LFD VIRL++NLTQP+ +CF +PKD F++V LQ K F VLS + ++ WEDR E+++LL+ERIL+L+RNILH+ N + S HD L+ + SG DLL++LS++ E++++ H LEIISLMFR+Q+ E + L ST+ A + LR++ E A++ + R RFGG++ +Q +K+ + ++H H++ DL K R+ + +E +H+ + VLN L++FC FL+ YN LM L R++ Q DETYY+WA+ FFM R P VSET++I FH+V Q Y + T ++ A S R++HL + AY+ELL +D +E R S IK+ +FY EY E++ L F R+FLR L+E + L +K+L E + G +RK K K ++Q + + P E L +W + E L+ + EL + DP++P + SE PV+ Q A+ +Q L + +A+A+ +++WPE + +++ EE+++LK I+ + ++++ + E E E ++E++ VQV E F+F +++ F +V + +L N TN+ + +++H +A +L+QL LF FN+ L DP + + I VN+ K +E+LF KN E GY S S + W+ E E +L L+ H+D+ G D I + +TR+Q+++ LV +GL S KE + +K WT D++ L L EE RD + +IM + A RSR V+ K+L LGLV + QL + + KL P+
Sbjct: 1 MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFG-SVPKDSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQRGNRHSRFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLG---KQPRRVPKRRQAAQELSVHRRS--VLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAATFRPGLVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKML----ERFCRSRGNLMVQNKRKKRKKKKKVQDQGVAFSQSPGE-------LEAMWPALAEQLLQCAQ-DPELSV------DPVVP-----FDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPEGNAFGSPVISPG-----EEMQLLKQIL-STPLPRQQEPEEGDAEEEEE----------EEEEEELQVVQVSEKEFNFLEYLKRFASSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLSLFCLFNRLLSDPAAAAYKELVTFAKYIIGKFFALAAVNQ--KAFVELLFWKNTAVVREMTQGYGSLDSGSSSHRAPLWSPEEEAQLQELYLA--HKDV-EGQDVVETILAHLKVVPRTRKQVIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLFEEFRDSDDVLGQIMKNITAK-------RSRARVVDKLLALGLVSERRQL-YKKRRKKLAPS 949
BLAST of Timeless circadian clock vs. UniProt/SwissProt
Match: sp|Q9Z2Y1|TIM_RAT (Protein timeless homolog OS=Rattus norvegicus OX=10116 GN=Timeless PE=1 SV=1) HSP 1 Score: 311.227 bits (796), Expect = 2.082e-86 Identity = 308/1002 (30.74%), Postives = 493/1002 (49.20%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFM-----DTLKSSNSTESASDQQLRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYH---HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNA---LQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKE----WTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNPWTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKNSKLIPN 3018
M+ Y+ + TC LG E + K+ D + S++D++R+LR E E ++R +LG +++++ L+ +L + D LFD VIRL++NLTQP+ +CF +PKD F++V LQ K F VLS + ++ WEDR E+++LL+ERIL+L+RNILH+ N + S HD L+ + SG DLL++LS++ E++++ H LEIISLMFR+Q E + L ST+ A + LR++ E A++ + R RFGG++ +Q +K+ R ++H H++ DL K R+ + +E +H+ + VLN L++FC FL+ YN LM L R++ Q DETYY+WA+ FFM R P VSET++I FH+V Q Y + T ++ A S R++HL + AY+ELL +D ++ R S IK+ +FY EY E++ L F R+FL L+E + L +K+L E + G +RK K K + Q + P E L+ +W + E L+ E EL ++ + +D PV+ Q A+ +Q L + +A+A+ +++WPE + + EE+++LK I+ A + +E E EEDE E E ++E++ VQV E F F +++ F +V + +L N TN+ + +++H +A +L+QL LF FN+ L DP + + I VN+ K +E+LF KN E GY + D + W+ E E +L L+ H+D+ G D I + +TR+Q+++ LV +GL S K+ + K + WT D++ L L EE +D + IM + A RSR V+ K+L LGLV + QL + + KL P+
Sbjct: 1 MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFG-SVPKDPTVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKRIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQKPEQLAGVGQGRLAQERSTDLAELEVLRQREVAEKRARALQRGNRHSRFGGSYVVQGLKSIGERDVVFHKGLHNLQNYSSDLG---KQPRRVPKRRQAAQELSVHRRS--VLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLREKAQQHDETYYMWAMAFFMAFNRAAAFRPGFVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDDAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLCDLVETTHLFLKML----ERFCRSRGNLMVQNKRKKRKKKKKAQEQGVAFSRSPEE-------LQAMWSALAERLLQCAQ-EPELSVDSIIPFDA----------ASEVPVEEQRVEAMVRIQDCLVAGQAPQALALLRSAREVWPEGN--VFGSPVISPGEEMQLLKQILSAT--------LPRQQEPVEGDAEEEDEEEEEEEEEELQVVQVSEKEFKFLDYLKRFACSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHDLGMEALLFQLSLFCLFNQLLSDPAAAAYKELVTFAKYILGKFFALAAVNQ--KAFVELLFWKNTSVVREMTQGYGSLDSGSCSHRAPVWSSEEEAQLQELYLA--HKDV-EGQDVVETILAHLKAVPRTRKQVIHHLVRMGLADSVKDFQRKGTQIVLWTEDQELELQRLFEEFQDSDDVLGHIMKNITAK-------RSRARVVDKLLALGLVSERRQLH-KKRRKKLAPS 951
BLAST of Timeless circadian clock vs. UniProt/SwissProt
Match: sp|G5EDN3|TIM_CAEEL (Protein timeless homolog OS=Caenorhabditis elegans OX=6239 GN=tim-1 PE=1 SV=1) HSP 1 Score: 174.866 bits (442), Expect = 1.340e-42 Identity = 175/685 (25.55%), Postives = 338/685 (49.34%), Query Frame = 1
Query: 91 LHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYL-KEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNST--ESASDQQLRRQRELELMAKSAENPRVKRFGGTFELQDIKTESGRPA--IYHHDINWSKIDLTRDRKLRRKA-KNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRF---FMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKES--AVSSYRKLHLVMSAYKELLEFCLMLDNH-QEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDD-GGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE---PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTD--DDNRVEEEIKILKDIMFANKFYKEEDLIK 2091
+ + LG E+ ++ ++ D S+RD++R+LR + + R+E G+ ++E L+ ++K + FD+ IRL++NL QP+ + + P D +++ +++E L+R K+ F D F + +I + ++ E+EDR E L+VERI++L++ + IN + S+G DS HD +++ +ESG L++++N E+ F L+I +L+ +EQ+AE + T ST + ++++ R+ E ++ ++ + RFGG++ ++ +K S + ++ N K + DRK +++A +N+ + +T H ++ +V L++ ++ +N LMK++ + + Q+Q + Y + ++F F+ + R++ L E +SE I + FH Q Y++N+ T + A S K + AY EL+ + H +EE R + + EY E+ ++ F S FLR L+ + +K+++ +FV + K K +K + + + ++ SE D L +W+E ++ + EV PE R DS+ PVD+Q K A +Q LR R AV ++ + LWPE + +TD D E++++ L+ ++ A+ +DL K
Sbjct: 5 VQGAVHALGYYEDGKYSREPDCYESIRDLIRYLREDGDDHTARIECGRHNLVEQDLVPMVKCEDLTDDEFDIAIRLMVNLCQPAISTMRGKPPADRDQWKMYWELEENLRRAKTAFSDAHFFTAIKKRIDNYFIDTEYEDRDERLRLVVERIVLLIKYVFSINPDTSEGRRTRIEDSSHDRVIIAFLESGIDKTLMHIANQPREKEFHVTILDIFALILKEQTAEDLATKSEEVSTAEQKKTEEEFRKIIENHVVKETQKRKSFSRFGGSYTIKGLKGISANSSQVVFKPIQNVEKHNFLDDRKAKKRAPRNRRPFEIDTNSHFASSEVRGMLRDMVIRIIETCFNRLMKSSKTTV-FVQVQKTSQINYFFLIKFVLRFVRLSRQDHLL-ERISECIGVEAFHENNVQLTEYVENATTLKGVEAKSHGLKAQYALGAYNELVLLHRYIYEHAKEENERKFAKRALEHIVNVEEYRELPIFIIKKFSSSVLSNNFLRELVLTTHHYMKLVE-------RFVKTGALKKVTKKVKVRKATKKSKMSEEDVRSEFDGMSKKDLDRLWEESKGLVLQILKKEV--------------PEMRGMNPIDSQLDVPVDAQQKFAKLSIQRSLRSRGFPAAVGLYHASRALWPESFKRGLTDFQDSPGEEDQLQELEQLLKADMKKVAKDLKK 666
BLAST of Timeless circadian clock vs. UniProt/SwissProt
Match: sp|O17482|TIM_DROVI (Protein timeless OS=Drosophila virilis OX=7244 GN=tim PE=2 SV=1) HSP 1 Score: 61.6178 bits (148), Expect = 5.178e-8 Identity = 50/223 (22.42%), Postives = 111/223 (49.78%), Query Frame = 1
Query: 976 RDRKLRRKAKNQVHNKEETYIHKSTDK-VLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYID----NSKTKESAVSSY-RKLHLVMSAYKELLEFCLMLD--NHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEF-GMKFVG 1617
R +KL +++K+ + N + +H D + N L+EF FL GYN L++ S L D +++ W + FF++ + +L E + +T V ++ + + + N++ + + + Y R++HLV++A +E L+ + H E R ++ ++ +++ ++ +LL F P S+ +L+ L+ + +++ IL + + G + +G
Sbjct: 520 RRKKLVKRSKSSLINMKGLVLHTPNDDDISNLLKEFTVDFLLKGYNYLVEELHSQLLSNAKMPIDTSHFFWLVTFFLKFAAQLELDMEHIDTILTFDVLSFLTYEGVSLCEQLELNARQEGADLRPYLRRMHLVVTAIREFLQAIEAYNKVTHLSEDDRYRLRQLQLQISATTDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDNAAKLEGGQTIG 742
BLAST of Timeless circadian clock vs. TrEMBL
Match: A0A3Q0KRK0 (Timeless, putative OS=Schistosoma mansoni OX=6183 PE=4 SV=1) HSP 1 Score: 421.779 bits (1083), Expect = 2.312e-122 Identity = 371/1090 (34.04%), Postives = 564/1090 (51.74%), Query Frame = 1
Query: 85 SDLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQLRRQRELELMAKS---------AENPRVKRFGGTFELQDIKTESGRPAIYHHDINW-------------SKIDLTRDRKL------RRKAKNQVHNKE--ETYIHK-STDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDN-------SKTKESAVSSYRKLHLVMSAYKELLEFCL--ML-------------DNHQ---EEKYRT---LSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDH-NEFGMKFVGXXXXXXXXXXXXXXANQE-------NQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVE--EEIKILKDIMFANKFYKEEDLIKLS-KEISEIGVVXXXXXXXXXXXXXINS------------VQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXD-PLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPK-EWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELK-------------NKKRENNP----WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPD-----------------------KLRSRGSVIKKILELGLVENKDQL 2982
+D+ AC +CLG E + D D S+R +LR+LR ET +C+IR ELG+ +++ + LI LL+ + + LF+LVIRLLMNLTQP+ +CF+QE+PKD +++VD++L+ K F D + VL + + + + WE+RSE++ LL+ERILIL+RN+LHI + + S HD ++ M SGW +LL++L+N+++E F FHTLEIISLM REQ+ E + + N E+ S+ RR+ L + A N R RFGG FEL + + S RP IYHHDI S +D+ + + +RK + H K + IH+ S V LQ FC FL+ YN +M+ S L RQ Q +DETY+LW +RFFM CR + + +SET+++P+FHW+Y Q + Y ++ + + A+ + R+L L ++ YKE L CL ML D Q EE+ R+ ++ SI + VFY +EY E++P LL + I S+ +LR L+EGS L I +L + K + K+ R R K SKA +E NQ + I + N L G ++E L+ E E + + D L ++ +SE D QLK A+ VQ L ++ A+++ + +LWPE + + +D++ ++ + + + ++ + +L K + +G + + D+ N +EV DFS F+ F HP VV+ + +L ED NP S N ++ +H +A K + +QL+LF F KFL D L+ +PEFK L + +I++KF E +N +L+E LF K E++ETV GY + N WT E ++EL +LFE +H+ + G D A ++ FSD +KTRRQI+ RL+TLGLI+S K+LK N++ NN WT E ARL +VE + + EIMN +K VD D +R+R V KILELGLV+N++QL
Sbjct: 10 ADIQACCSCLGFREGDTYKIDTDAEVSIRTLLRYLRNETAECDIRRELGQLRIVSSDLIPLLRCCSGNKTLFELVIRLLMNLTQPAIVCFRQEVPKDRDLYSAYLQVDDLLKSYKKDFADEELFRVLCNLVGSLLDRSWEERSEEDRLLIERILILIRNVLHIAPDVVGEQRTDEDVSVHDQILWAMHLSGWDELLLFLANSDDERMFAFHTLEIISLMLREQTPELLAC--AGNRAETKSELNKRRKLIERLKIRDDAERKNFLYACNLRQARFGGAFELVNTPSLSERPLIYHHDITHTAQMATVISKQLDSSVDVVDNVGIVELDVGKRKFRKPKHRKPLVDRSIHRRSILAVQLYLQGFCWQFLKFCYNPIMRVVQSGLTRQATQENDETYFLWTMRFFMAFCRVYRFRSDYISETLSVPIFHWIYDQVINYKEHLVTNKRGGASNQRAMQAARRLELAVACYKEFLT-CLNRMLHVTGADKTVQPGDDETQDGVEERLRSQANVAESIIANVFYVAEYQEVFPNLLRDYNEIFMSKDYLRDLVEGSHLFITLLSNKICGSNKKIIVKRRRVHRMKKRSSKAKKETRKKAILNQEPEDVRISRLKQQWSNQLEG---PLIEILLGTAYQESEQDESDDEMNDTRL---FDATTGNSE--DQQLKSAIRRVQAALFAGSAKRALSMAKRMWRLWPEVAPVSIEEDNSAIDAGRAAGLRPECLNVLGALQQIHMTELGDKRLFILGALNNSSSNSSDGDDLYNEELGISDSNDELVTTEKEVVLDFSAFMLKFVHPRVVHAYTLLLEDYDNNPESVNRAIVHTIHRLAVKERLTGCFFQLRLFRVFQKFLHDRALATSPEFKELANLIKYILRKFFEAEERNNYILIETLFFKTPKESYETVQGYGTFESNKKTIHWTSEHDKELTQLFEAYRHDPVPSGNDLADLLVKYFSDSSKTRRQIVARLITLGLITSLKQLKEITVRPPKPLSGRNRRLLNNGESSEWTEQEIARLRDIVELHKGSKNMLTEIMNEIK---VDHDLAVQRCLEQELIMDENQSGKYIPPIRARRVVAAKILELGLVDNENQL 1085
BLAST of Timeless circadian clock vs. TrEMBL
Match: A0A0X3PCW4 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=TR104658 PE=4 SV=1) HSP 1 Score: 408.683 bits (1049), Expect = 7.002e-117 Identity = 373/1126 (33.13%), Postives = 561/1126 (49.82%), Query Frame = 1
Query: 85 SDLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENE-ERFTFHTLEIISLMFREQSAEFMDT------LKSSNSTESASDQQLR-RQRELELMAKSAENPRVKRFGGTFELQDIKTESGRPAIYHHDI----------------------------NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYID-------NSKTKESAVSSYRKLHLVMSAYKELL---------------EFCLMLDNHQEEKYRTLSA------SIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEI--------------PSEQDDGGNVLRGIW--DEMLET------------LMSAVNGEVELPLN---LPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVT-------DDDNR-------------VEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXIN------SVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDP-LSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKE-WTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKEL------------KNKKRENNPWTADEQARLIILVEESRDQPIPIKEIMNGLKATAVD--------------PD----------KLRSRGSVIKKILELGLVENKDQLG 2985
+DL AC C+G + + D D SLR ILR+LR E+ C+IR ELG+ K+I + L+ L+K + + LFDL IRLL+NLTQP+ +CF+ ELPKD +++VD +L+ CK F D VL+S++ +++ K W +RS D+ LL+ERILIL+RN+LHI + S + S HD L+ M SGW +LL++++NAE+E + F FHTLEIISLM REQ+ E + + + ++ + ES ++LR R++E + A N R RFGGTFEL + K+ S RP IYHHD+ + +DL + +RRKA+N+ E +S V LQ FC FL YN LM A S + RQ QA+DETYYLWA+ FFM CR E VSET+++PVFHWVYQ +M Y + T +A+ S R+L L +SAY++ L L+ + EE+ + L A S+ + +FY ++Y+++YP+LL + Q++ +L L EG+ L + ++ + V + + +RR++ + + +E Q E+ P E+ R +W D T L++ NG ++ N LP ++DP E+ D + V +QL+ A+ LV L++ ++A+ I L ++WPE T DDD + E LK I + EE+L L K I E + +E E + ++ SV +EV D + F H + + +L E+ NPP+TN+ L+R+ H +A + + P +Q++LF F + DP +S EF+ L KF+ +I++KF E +NR + +E LF K+ E+ E GY D + WT EL++EL +LF+ + E + G D A V++ SD KTRRQI+ RL+ L I SAK L + +R PWT +E RL L EE P + ++MN LK D PD LRSR V +K++ELGLV + Q G
Sbjct: 10 ADLQACCVCIGFKDEDAYKVDADAEASLRSILRYLRAESSSCDIRRELGRLKIITSDLLPLMKTPDITNALFDLTIRLLVNLTQPAIVCFRHELPKDRDLYTCYMQVDNLLKDCKKAFADEQAFRVLASRVENLFNKTWVERSNDDRLLIERILILIRNVLHITPDTSSEHRTDEDVSVHDQLLWAMHLSGWDELLLFMANAEDERDNFAFHTLEIISLMLREQTPELLASAGKPADVAAAMNPESQVLERLRLREKEWKRAALVELNMRHNRFGGTFELLNTKSLSDRPLIYHHDVTAPLMCAKMRHDPIDGTESSGDVGSLTADVGLVDLNLGKTVRRKARNRKPLLERDLHRRSIFAVQLYLQNFCWQFLCNCYNPLMNAARSAILRQTTQANDETYYLWAMHFFMAFCRLYNFRAELVSETLSVPVFHWVYQLSMSYREAVLADRKGGGTNVTALHSSRRLALAVSAYRQFLLSLQEMARPGSTVVTPAALICQENPEERSQRLKAHKQAAESLMANIFYIADYLDLYPLLLREYNESVQTKQYLIDLAEGANLFLNLISAQEKTNKTLVVSQRQRRRRRTEEQRKKREQQKQRRRELQAARRRAQRRAGQTPEER---AAERRLVWTGDPAAGTNNTTSLSYRLLRLLADQNGSLQTAENAEELPQLFDP----TAETEADDRDAVAAQLRNAIRLVHTALQEGRLMQALRIARLMWEIWPESAPTTATMNEQDEHDDDGQDMTRALEAGLAPSAVSEFIALKRIFMLD--LVEEELEAL-KRIGEDITDDAEEEEEDLIARELEDSDDEFSVINKEVSLDLDNLLLKFAHAHTIRNLTLLLENYALNPPTTNDCLVRLFHRVAVRRRLPGACFQVRLFRVFQSIVNDPGISKQDEFQELLKFIKYILRKFFEAFERNRNVSVEALFLKSAKESFEAFNGYGTFDAGSRASVWTPELDQELGQLFDAYRFEPVPKGEDLADVLQRLLSDPGKTRRQIIMRLIYLTKIDSAKSLRMMTCRSAEDERRGSRRPKRPWTEEEVERLKTLFEEHSGTPYFLSDLMNTLKFEYEDRVKSLENAGSLEEVPDIAAADSSTQPLLRSRKEVGQKLIELGLVSSPSQFG 1125
BLAST of Timeless circadian clock vs. TrEMBL
Match: G4LZH9 (Timeless, putative OS=Schistosoma mansoni OX=6183 GN=Smp_163340 PE=4 SV=1) HSP 1 Score: 396.356 bits (1017), Expect = 3.614e-113 Identity = 367/1098 (33.42%), Postives = 560/1098 (51.00%), Query Frame = 1
Query: 85 SDLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQLRRQRELELMAKS---------AENPRVKRFGGTFELQDIKTESGRPAIYHHDINW-------------SKIDLTRDRKL------RRKAKNQVHNKE--ETYIHK-STDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDN-------SKTKESAVSSYRKLHLVMSAYKELLEFCL--ML-------------DNHQ---EEKYRT---LSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDH-NEFGMKFVGXXXXXXXXXXXXXXANQE-------NQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEE------------IKILKDIMFANKFYKEEDLIKLSKEIS-----------EIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXD-PLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPK-EWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELK-------------NKKRENNP----WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPD-----------------------KLRSRGSVIKKILELGLVENKDQL 2982
+D+ AC +CLG E + D D S+R +LR+LR ET +C+IR ELG+ +++ + LI LL+ + + LF+LVIRLLMNLTQP+ +CF+QE+PKD +++VD++L+ K F D + VL + + + WE+RSE++ LL+ERILIL+RN+LHI + + S HD ++ M SGW +LL++L+N+++E F FHTLEIISLM REQ+ E + + N E+ S+ RR+ L + A N R RFGG FEL + + S RP IYHHDI S +D+ + + +RK + H K + IH+ S V LQ FC FL+ YN +M+ S L RQ Q +DETY+LW +RFFM CR + + +SET+++P+FHW+Y Q + Y ++ + + A+ + R+L L ++ YKE L CL ML D Q EE+ R+ ++ SI + VFY +EY E++P LL + I S+ +LR L+EGS L I +L + K + K+ R R K SKA +E NQ + I + N L G ++E L+ E E + + D L ++ +SE D QLK A+ VQ L ++ A+++ + +LWPE + + +D++ ++ + L+ I +EE+ L+ S E+G+ + ++ + T+ E + + F R + ++ +L ED NP S N ++ +H +A K + +QL+LF F KFL D L+ +PEFK L + +I++KF E +N +L+E LF K E++ETV GY + N WT E ++EL +LFE +H+ + G D A ++ FSD +KTRRQI+ RL+TLGLI+S K+LK N++ NN WT E ARL +VE + + EIMN +K VD D +R+R V KILELGLV+N++QL
Sbjct: 10 ADIQACCSCLGFREGDTYKIDTDAEVSIRTLLRYLRNETAECDIRRELGQLRIVSSDLIPLLRCCSGNKTLFELVIRLLMNLTQPAIVCFRQEVPKDRDLYSAYLQVDDLLKSYKKDFADEELFRVLCDLVGSLLDRSWEERSEEDRLLIERILILIRNVLHIAPDVVGEQRTDEDVSVHDQILWAMHLSGWDELLLFLANSDDERMFAFHTLEIISLMLREQTPELLAC--AGNRAETKSELNKRRKLIERLKIRDDAERKNFLYACNLRQARFGGAFELVNTPSLSERPLIYHHDITHTAQMATVISKQLDSSVDVVDNVGIVELDVGKRKFRKPKHRKPLVDRSIHRRSILAVQLYLQGFCWQFLKFCYNPIMRVVQSGLTRQATQENDETYFLWTMRFFMAFCRVYRFRSDYISETLSVPIFHWIYDQVINYKEHLVTNKRGGASNQRAMQAARRLELAVACYKEFLT-CLNRMLHVTGADKTVQPGDDETQDGVEERLRSQANVAESIIANVFYVAEYQEVFPNLLRDYNEIFMSKDYLRDLVEGSHLFITLLSNKICGSNKKIIVKRRRVHRMKKRSSKAKKETRKKAILNQEPEDVRISRLKQQWSNQLEG---PLIEILLGTAYQESEQDESDDEMNDTRL---FDATTGNSE--DQQLKSAIRRVQAALFAGSAKRALSMAKRMWRLWPEVAPVSIEEDNSAIDAGRAAGLRPECLNVLGALQQIHMTELEEEEEEQEALNNSSSNSSDGDDLYNEELGISDSNDELVTTEKEVVLDFSAFMLKFVHPRVVHAYT---------LLLEDYDNNPESVNRAIVHTIHRLAVKERLTGCFFQLRLFRVFQKFLHDRALATSPEFKELANLIKYILRKFFEAEERNNYILIETLFFKTPKESYETVQGYGTFESNKKTIHWTSEHDKELTQLFEAYRHDPVPSGNDLADLLVKYFSDSSKTRRQIVARLITLGLITSLKQLKEITVRPPKPLSGRNRRLLNNGESSEWTEQEIARLRDIVELHKGSKNMLTEIMNEIK---VDHDLAVQRCLEQELIMDENQSGKYIPPIRARRVVAAKILELGLVDNENQL 1084
BLAST of Timeless circadian clock vs. TrEMBL
Match: R7U1C1 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_19701 PE=4 SV=1) HSP 1 Score: 388.652 bits (997), Expect = 4.511e-110 Identity = 326/980 (33.27%), Postives = 526/980 (53.67%), Query Frame = 1
Query: 88 DLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNS-TESASDQ-QLRRQRELELMAKSAE----NPRVKRFGGTFELQDIKTESGRPAIYHHDINWS-KIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEP----DSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXX-XXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNN--PK-EWTDXXXXXXXXXXXXXQHEDIL-PGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNK--KRENNPWTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVEN 2970
+L A LG TE ++LK+ D + +++D++R L+RE + C+IR +LG+ ++++N LI L+K Y ++ +L + VIRL++NLTQP+ +CF+ ++P D F++++ LQ K F D +L+ K+ D+ ++E+R E++ LL+ERILIL+RNILH+ N + S HD ++ + SG +DLL++L+ +++E +FT H LEIISLMFREQ+ E + + ++ S TE D+ +L RE E + K + N R RFGGTF + ++K+ + R I+H ++ + +I ++ ++ KN+ E +ST + L+EFC FLQ +N LM+ L R + Q +DETYYLWA+RFFMEV RR+ + VSET+++ FH+V Q +Y++ T K+ + R++HL + AY ELL +D +++ R + I+ VFY EY +I+ ++L F +QSRAFLR L+E + L +K+L+ + + + +K++ K+ + K KA N +E+ EQ L +WD +V+G V V+ P E + P P+D Q A+ +Q LR + EAVA+F+ +++WP DR +++ E E L++I+ N D L + E EE++ E +E E FDF F+ F P VV + +L +D N N ++++H IA Q +L+Q +L N L D + F+ L F I++KF + KNRK+ EV F K EA E V GY +D + PK W++E EL RL EE + ++ PG D I D +KTRRQ++ +LV L +I+ AK+LK + R W +E+A L L E ++ P P+ I++ + A RS+ V KK+L +G+V +
Sbjct: 5 ELQATCASLGYTEGDKYLKEPDCLETVKDLIRFLKREDDSCDIRRDLGESQIVQNDLIPLVKHYADERILLETVIRLMVNLTQPAKLCFQNQIPDDKTQRNHFLQIEAHLQGYKQAFTDEALFAILTKKLGDLLSLDYENREEEDRLLIERILILIRNILHVPPNTQKEQRTDDDASTHDQVLWALHMSGMEDLLLFLATSDDENQFTLHVLEIISLMFREQTPEQIASSGAARSLTEREKDERELTIAREKEKVRKKTQVLKYNSRHSRFGGTFTVANMKSITDRDLIFHRPVSKANEISFDHNKTRKKAPKNRQPITAEEVTRRSTLSIRMFLKEFCLQFLQNCFNPLMRAVKDALNRSKAQENDETYYLWAVRFFMEVNRRHSFRIDLVSETLSVASFHYVQTQLQLYLEMMITNKKEGIVWSRRMHLALKAYHELLLNLFEMDRSKDKAVRDSAKVIEGNVFYMMEYRDIFLIMLRKFDESRQSRAFLRELVETTHLFLKMLEGYCKQHRHLMVQKTKKKKPQKSKKKATANINN--NVELTQEQ------LIELWD--------SVSGGVS-----AVLQSGEEPSGAEGVVPFDAASQVPLDQQRIDAVFRIQEFLRADKAAEAVALFKASREVWP--DRPEFGEENMTTEAEFMSLREILLTN---LPRDACSLPEHQEENEEQEEEQEEEVEQEEYAGMADTTEQEFDFKEFVTRFASPLVVKAYTMLLQDFPRNSAQINRCCVKMLHRIAFDLNQVGMLFQARLFRVFQNVMLKDEHRSLSCFQELSTFGKHILRKFFDAALKNRKIFAEVFFWKGTKEALEIVDGYGTYNDRSKAPKVTWSEEENMELQRLCEEFKEKNAADPGADLGDYIVQNLIDDSKTRRQVVRQLVHLDIITCAKDLKRRTGARSLRGWREEEEAELRQLYELHKEDPDPLGSIISEMSAP-------RSKPVVSKKLLSMGIVSD 951
BLAST of Timeless circadian clock vs. TrEMBL
Match: A0A0R3W7S8 (Uncharacterized protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS6354 PE=4 SV=1) HSP 1 Score: 380.948 bits (977), Expect = 4.464e-108 Identity = 339/1100 (30.82%), Postives = 537/1100 (48.82%), Query Frame = 1
Query: 85 SDLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENE-ERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQLRRQRELELMAKSAENPRVKRFGGTFELQDIKTESGRPAIYHHDIN----------------------WSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYID-------NSKTKESAVSSYRKLHLVMSAYKELLEFCL-------------------------------MLDNHQEEKY--RTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFV----GXXXXXXXXXXXXXXANQENQN----------IGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVEL--PLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWP-----------EEDRIMVTDDDNRVEEEI---KILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXIN---------SVQV--REVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNN-PEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPK-EWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENN------------PWTADEQARLIILVEESRDQPIPIKEIMNGLK---------------ATAVDPDKLRSRGSVIKKILELGLVENKDQLG 2985
+DL AC CLG + ++ D D SLR ILR+LR E+ C+IR ELG K++ + LI LLK+ D LFDLVIRL+++LTQP+ +CF+ E+P D F+KVD +L+ K F D VL+ ++ D++ K WEDRS+D+ LL+ERILIL+RN+LHI+ + + + S HD L+ + SGW DLL++L+NA++E F FH LEI SLM RE+ E K S S + S+ N RFGGTFEL + ++ S RP IYHHD+ ++DL +++RRKA N+ E + +S V LQ+FC +FL+ YN LM A + R+ +QA+DETYYLW+++FFM CR + P+ +SE++ VF+WVY +M Y + +SA+ R+L L +SA ++ L CL L+ + + + ++ S+ S +FY +EY +++ LL + QS+ +L L+EG+ L I +L + + + ++ + +K +K A++E Q E P E+ L IW + L+SA++ +L +LP ++DP + D E + +QL+ A+ LV L ++ ++AI +WP EE +V + +E + ++L+ + F DL EI+E + E + ++ + S+QV +E+ FD + F+ F HP+++ + +L + NP STN L+ ++H + K P VL+QL+LF F + DP+ EF+ + F+ +I++KF E ++ +++E LF K+ EA E GY + + K WT EL++EL +LFE +++ + G D V++ SD TRRQI+ RL+ LG ++SAK LK + PW+ +E L L E + ++M L+ AT V LRSR V +K+ ELGL + G
Sbjct: 10 ADLQACCVCLGFLDENKYKVDADAPASLRSILRYLRNESSSCDIRRELGNLKILTSDLIPLLKVSGADPTLFDLVIRLMVSLTQPAVVCFRNEIPNDRDLYAAFLKVDAILKDYKYAFADEHLFRVLAERVEDLFNKSWEDRSDDDRLLIERILILIRNVLHISPDAATEHRTDDDVSVHDQLLWTIHISGWDDLLLFLANAKDELNVFAFHILEIASLMLREKFTE-----KRSTSLPT---------------IHSSHN----RFGGTFELLNTQSISSRPLIYHHDVTVPLRQSCSTCVKTGAKHAEFGAIDQVDLDLGKRMRRKACNRKPLIEREFRRRSVLSVQLFLQKFCWLFLRNCYNLLMYEARGAILRRSIQANDETYYLWSMQFFMAFCRLYRFRPQYLSESLNASVFNWVYALSMGYREALLTDRRGGARNQSALQWSRRLALAVSANRQFL-LCLQEMSKPSKEALRGKGFGGCGGGNDEEEGGEETLETREHRLFVQKQVAESLMSNIFYVAEYQDLFVFLLKEYNESIQSKEYLVELVEGAHLFISLLIAQAKSTVTLIVSRRQRRRHRREQKRLKYSAHRERQKKLAEARKRLLKRANETPEER---SAFLARIWTPLSSNLISALSSTPQLMSSDDLPQLFDP------ADVSADGESMAAQLRNAIRLVHTNLHNNQAVRSLAIARSMWDIWPEALPSNDMEEGEETEDLVKEKARAIEAGLGPSQVLEYLALRKIFLL--DLTAEELEITEAAIEEARNIDDAGEELALQESEDSNDECSLQVLDKEIAFDINAFLLRFTHPHIIRSLTLLLANYALNPSSTNTHLVHLLHKVTVKQHLPGVLFQLRLFYVFQTIIKDPVVGKLDEFQEMLCFIKYILRKFFETFERSHLVVVETLFLKSTREAAEAHNGYGTYESGHKKFYWTAELDKELDQLFEVYRYDPVPKGEDLVDVLKRNLSDPKMTRRQIIMRLIHLGKVASAKNLKMMTIRSGDGRTVRRSRRRPPWSEEEVNLLRSLFIEHEGSFHRLNDVMTELRLDYEQRMRQEDSEMPATVV----LRSRREVERKLTELGLARGLNDFG 1069
BLAST of Timeless circadian clock vs. Ensembl Cavefish
Match: timeless (timeless circadian regulator [Source:NCBI gene;Acc:103032261]) HSP 1 Score: 338.961 bits (868), Expect = 1.553e-96 Identity = 300/994 (30.18%), Postives = 509/994 (51.21%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQ--------LRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFV-GXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKE---WTDXXXXXXXXXXXXXQHEDILPGFDKASVIES---RFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E + + K+ D + S++D++R+LR E + +IR +LG ++++N L+ ++ + D LFD IRL++NLTQP+ +CF + +P D F+++ L K F + VLS + ++ +WE R E+++LL+ERIL+L+RN+LH+ + + + S HD L+ + SG DLL +L++A++E++++ H LE+ISLMFR+Q+ E L S+ + SA ++Q LR++ + E ++ + R RF G++ ++ +K+ + I+H + N+ + RR K + ++ +S V L+EFC FL+ YN LM L R+ Q DETYY+WAL FFM R N E VSET+++ FH++ + Y + T K+ A S R++HL + AY+ELL +D+ ++E R + IKS +FY EY EI+ LL F Q R+FLR L+E + L +++L+ +F G+ + ++K K ++ + T P L W + E L S E V +D SE PV Q A+ +Q + R EA+++ +++WPE + + + + EEE+++LK I+FA +L + ++ +E + E+D+ ++E++ SV+V E F+F FI+ F PN+V + +L TN P TN+ ++R++H + K +L+QL +F FNK L DP ++ + I +N K +E+LF KN+ E GYS D K+ WT EEE +H+D + ++E+ S+ N+TRR ++ ++V++GL+ S K+LK +++ WT D++ L +L EE +D + I+ L A RSR V+ KIL +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLEGETYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAGQILQNDLLPIITQHGQDKPLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQIVSYLHAYKEAFANEKVFAVLSETLYNLLQLDWEQRQEEDNLLIERILLLIRNVLHVPPDPYEEKNVDDDASVHDKLLWAIHMSGMDDLLKFLASAQSEQQWSMHVLEVISLMFRDQTPE---QLVSAGHSRSAQEKQKDTSELESLRQKEQAEKRSRIMQRGNRHSRFRGSYVVEGLKSIGEKDVIFHSGLHNFKNYSHDAGKATRRVPKRKQMARDTDSQRRSVLNVRLFLREFCVDFLENCYNRLMYLVKESLIREHAQQHDETYYMWALSFFMAFNRGNGCKAELVSETLSVRAFHFIEKNITNYYEMMLTDKKEATSWSRRMHLALKAYQELLMTVNEMDHSKDENIRQSANVIKSNIFYLMEYREIFLTLLRKFDERMQPRSFLRDLVESTHLFLRMLE-------RFCKGRNNLLVQKKKAKRTTRKKKPSAPTENTP-------EALEETWKIISEELQSCGFQLSEALTEGAVPFDAA-----------SEIPVTEQRTEAMIRIQDAVLARTGPEALSLLRAAREVWPEGN--VFGSAEVQPEEELELLKQILFA-------ELPRPTQ--TEAAMDEDDDGAELEEEEELESVRVSETEFNFLDFIKRFASPNIVRPYLILLRSYATNTPHTNHCVVRMLHRVGVDLKMDALLFQLSVFYLFNKILSDPAASAYKELVTFAKYILNRFFAL--AARNNKAFIELLFWKNVGAVREMTEGYSKDGDGAGKKKVIWT--PEEEEELRQLYEEHKDS----EDPDIVETLLPLLSNTNRTRRHVVAQMVSMGLVDSVKDLKKERKGTRIVLWTEDQEQELQMLFEEYKDSEDILGNILKHLTAK-------RSRARVVDKILSMGLVSDRREL 939
BLAST of Timeless circadian clock vs. Ensembl Cavefish
Match: timeless (timeless circadian regulator [Source:NCBI gene;Acc:103032261]) HSP 1 Score: 338.961 bits (868), Expect = 1.553e-96 Identity = 300/994 (30.18%), Postives = 509/994 (51.21%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQ--------LRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFV-GXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKE---WTDXXXXXXXXXXXXXQHEDILPGFDKASVIES---RFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E + + K+ D + S++D++R+LR E + +IR +LG ++++N L+ ++ + D LFD IRL++NLTQP+ +CF + +P D F+++ L K F + VLS + ++ +WE R E+++LL+ERIL+L+RN+LH+ + + + S HD L+ + SG DLL +L++A++E++++ H LE+ISLMFR+Q+ E L S+ + SA ++Q LR++ + E ++ + R RF G++ ++ +K+ + I+H + N+ + RR K + ++ +S V L+EFC FL+ YN LM L R+ Q DETYY+WAL FFM R N E VSET+++ FH++ + Y + T K+ A S R++HL + AY+ELL +D+ ++E R + IKS +FY EY EI+ LL F Q R+FLR L+E + L +++L+ +F G+ + ++K K ++ + T P L W + E L S E V +D SE PV Q A+ +Q + R EA+++ +++WPE + + + + EEE+++LK I+FA +L + ++ +E + E+D+ ++E++ SV+V E F+F FI+ F PN+V + +L TN P TN+ ++R++H + K +L+QL +F FNK L DP ++ + I +N K +E+LF KN+ E GYS D K+ WT EEE +H+D + ++E+ S+ N+TRR ++ ++V++GL+ S K+LK +++ WT D++ L +L EE +D + I+ L A RSR V+ KIL +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLEGETYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAGQILQNDLLPIITQHGQDKPLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQIVSYLHAYKEAFANEKVFAVLSETLYNLLQLDWEQRQEEDNLLIERILLLIRNVLHVPPDPYEEKNVDDDASVHDKLLWAIHMSGMDDLLKFLASAQSEQQWSMHVLEVISLMFRDQTPE---QLVSAGHSRSAQEKQKDTSELESLRQKEQAEKRSRIMQRGNRHSRFRGSYVVEGLKSIGEKDVIFHSGLHNFKNYSHDAGKATRRVPKRKQMARDTDSQRRSVLNVRLFLREFCVDFLENCYNRLMYLVKESLIREHAQQHDETYYMWALSFFMAFNRGNGCKAELVSETLSVRAFHFIEKNITNYYEMMLTDKKEATSWSRRMHLALKAYQELLMTVNEMDHSKDENIRQSANVIKSNIFYLMEYREIFLTLLRKFDERMQPRSFLRDLVESTHLFLRMLE-------RFCKGRNNLLVQKKKAKRTTRKKKPSAPTENTP-------EALEETWKIISEELQSCGFQLSEALTEGAVPFDAA-----------SEIPVTEQRTEAMIRIQDAVLARTGPEALSLLRAAREVWPEGN--VFGSAEVQPEEELELLKQILFA-------ELPRPTQ--TEAAMDEDDDGAELEEEEELESVRVSETEFNFLDFIKRFASPNIVRPYLILLRSYATNTPHTNHCVVRMLHRVGVDLKMDALLFQLSVFYLFNKILSDPAASAYKELVTFAKYILNRFFAL--AARNNKAFIELLFWKNVGAVREMTEGYSKDGDGAGKKKVIWT--PEEEEELRQLYEEHKDS----EDPDIVETLLPLLSNTNRTRRHVVAQMVSMGLVDSVKDLKKERKGTRIVLWTEDQEQELQMLFEEYKDSEDILGNILKHLTAK-------RSRARVVDKILSMGLVSDRREL 939
BLAST of Timeless circadian clock vs. Ensembl Cavefish
Match: timeless (timeless circadian regulator [Source:NCBI gene;Acc:103032261]) HSP 1 Score: 338.961 bits (868), Expect = 1.553e-96 Identity = 300/994 (30.18%), Postives = 509/994 (51.21%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQ--------LRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFV-GXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKE---WTDXXXXXXXXXXXXXQHEDILPGFDKASVIES---RFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M+ Y+ + TC LG E + + K+ D + S++D++R+LR E + +IR +LG ++++N L+ ++ + D LFD IRL++NLTQP+ +CF + +P D F+++ L K F + VLS + ++ +WE R E+++LL+ERIL+L+RN+LH+ + + + S HD L+ + SG DLL +L++A++E++++ H LE+ISLMFR+Q+ E L S+ + SA ++Q LR++ + E ++ + R RF G++ ++ +K+ + I+H + N+ + RR K + ++ +S V L+EFC FL+ YN LM L R+ Q DETYY+WAL FFM R N E VSET+++ FH++ + Y + T K+ A S R++HL + AY+ELL +D+ ++E R + IKS +FY EY EI+ LL F Q R+FLR L+E + L +++L+ +F G+ + ++K K ++ + T P L W + E L S E V +D SE PV Q A+ +Q + R EA+++ +++WPE + + + + EEE+++LK I+FA +L + ++ +E + E+D+ ++E++ SV+V E F+F FI+ F PN+V + +L TN P TN+ ++R++H + K +L+QL +F FNK L DP ++ + I +N K +E+LF KN+ E GYS D K+ WT EEE +H+D + ++E+ S+ N+TRR ++ ++V++GL+ S K+LK +++ WT D++ L +L EE +D + I+ L A RSR V+ KIL +GLV ++ +L
Sbjct: 1 MDLYMMNCELLATCSALGYLEGETYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAGQILQNDLLPIITQHGQDKPLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQIVSYLHAYKEAFANEKVFAVLSETLYNLLQLDWEQRQEEDNLLIERILLLIRNVLHVPPDPYEEKNVDDDASVHDKLLWAIHMSGMDDLLKFLASAQSEQQWSMHVLEVISLMFRDQTPE---QLVSAGHSRSAQEKQKDTSELESLRQKEQAEKRSRIMQRGNRHSRFRGSYVVEGLKSIGEKDVIFHSGLHNFKNYSHDAGKATRRVPKRKQMARDTDSQRRSVLNVRLFLREFCVDFLENCYNRLMYLVKESLIREHAQQHDETYYMWALSFFMAFNRGNGCKAELVSETLSVRAFHFIEKNITNYYEMMLTDKKEATSWSRRMHLALKAYQELLMTVNEMDHSKDENIRQSANVIKSNIFYLMEYREIFLTLLRKFDERMQPRSFLRDLVESTHLFLRMLE-------RFCKGRNNLLVQKKKAKRTTRKKKPSAPTENTP-------EALEETWKIISEELQSCGFQLSEALTEGAVPFDAA-----------SEIPVTEQRTEAMIRIQDAVLARTGPEALSLLRAAREVWPEGN--VFGSAEVQPEEELELLKQILFA-------ELPRPTQ--TEAAMDEDDDGAELEEEEELESVRVSETEFNFLDFIKRFASPNIVRPYLILLRSYATNTPHTNHCVVRMLHRVGVDLKMDALLFQLSVFYLFNKILSDPAASAYKELVTFAKYILNRFFAL--AARNNKAFIELLFWKNVGAVREMTEGYSKDGDGAGKKKVIWT--PEEEEELRQLYEEHKDS----EDPDIVETLLPLLSNTNRTRRHVVAQMVSMGLVDSVKDLKKERKGTRIVLWTEDQEQELQMLFEEYKDSEDILGNILKHLTAK-------RSRARVVDKILSMGLVSDRREL 939
BLAST of Timeless circadian clock vs. Ensembl Cavefish
Match: timeless (timeless circadian regulator [Source:NCBI gene;Acc:103032261]) HSP 1 Score: 335.109 bits (858), Expect = 7.130e-96 Identity = 331/1163 (28.46%), Postives = 553/1163 (47.55%), Query Frame = 1
Query: 70 MEKYLSDLHACITC--LGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQ--------LRRQRELELMAKSAENP-RVKRFGGTFELQDIKTESGRPAIYHHDI-NWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFV-GXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIES---RFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL-GIRDKNSKLIPNYDSGSXXXXXXXXXXXXXXXXXXSRFMNDLFHQSLSSIKRNPPALKVKRKIDWDTLKIIYAQLDTKVQEWFVETLEDNIDSR-ANGIVGPLAIVPLREHDSEILENKLLQRLLYICEFLYPDQSKGHLFWRIPEEMTAKELEYFKNCVTSLTESELEALA 3495
M+ Y+ + TC LG E + + K+ D + S++D++R+LR E + +IR +LG ++++N L+ ++ + D LFD IRL++NLTQP+ +CF + +P D F+++ L K F + VLS + ++ +WE R E+++LL+ERIL+L+RN+LH+ + + + S HD L+ + SG DLL +L++A++E++++ H LE+ISLMFR+Q+ E L S+ + SA ++Q LR++ + E ++ + R RF G++ ++ +K+ + I+H + N+ + RR K + ++ +S V L+EFC FL+ YN LM L R+ Q DETYY+WAL FFM R N E VSET+++ FH++ + Y + T K+ A S R++HL + AY+ELL +D+ ++E R + IKS +FY EY EI+ LL F Q R+FLR L+E + L +++L+ +F G+ + ++K K ++ + T P L W + E L S E V +D PV Q A+ +Q + R EA+++ +++WPE + + + + EEE+++LK I+FA +L + I I VV F PN+V + +L TN P TN+ ++R++H + K +L+QL +F FNK L DP ++ + I +N K +E+LF KN+ E GYS D WT EEE +H+D + ++E+ S+ N+TRR ++ ++V++GL+ S K+LK +++ WT D++ L +L EE +D + I+ L A RSR V+ KIL +GLV ++ +L R +N+ + SG+ + + E+++E E+ D + ++ P I W T L V W L D R +G+ P+ +VPL E + + +ENK QRLL P + FWRIP ++ +L + L E+E+ A
Sbjct: 1 MDLYMMNCELLATCSALGYLEGETYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAGQILQNDLLPIITQHGQDKPLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQIVSYLHAYKEAFANEKVFAVLSETLYNLLQLDWEQRQEEDNLLIERILLLIRNVLHVPPDPYEEKNVDDDASVHDKLLWAIHMSGMDDLLKFLASAQSEQQWSMHVLEVISLMFRDQTPE---QLVSAGHSRSAQEKQKDTSELESLRQKEQAEKRSRIMQRGNRHSRFRGSYVVEGLKSIGEKDVIFHSGLHNFKNYSHDAGKATRRVPKRKQMARDTDSQRRSVLNVRLFLREFCVDFLENCYNRLMYLVKESLIREHAQQHDETYYMWALSFFMAFNRGNGCKAELVSETLSVRAFHFIEKNITNYYEMMLTDKKEATSWSRRMHLALKAYQELLMTVNEMDHSKDENIRQSANVIKSNIFYLMEYREIFLTLLRKFDERMQPRSFLRDLVESTHLFLRMLE-------RFCKGRNNLLVQKKKAKRTTRKKKPSAPTENTP-------EALEETWKIISEELQSCGFQLSEALTEGAVPFDA----------ASEIPVTEQRTEAMIRIQDAVLARTGPEALSLLRAAREVWPEGN--VFGSAEVQPEEELELLKQILFA----------ELPRPIRSIKVV--------------------------------FASPNIVRPYLILLRSYATNTPHTNHCVVRMLHRVGVDLKMDALLFQLSVFYLFNKILSDPAASAYKELVTFAKYILNRFFAL--AARNNKAFIELLFWKNVGAVREMTEGYSK-DGCKKVIWTP--EEEEELRQLYEEHKDS----EDPDIVETLLPLLSNTNRTRRHVVAQMVSMGLVDSVKDLKKERKGTRIVLWTEDQEQELQMLFEEYKDSEDILGNILKHLTAK-------RSRARVVDKILSMGLVSDRRELYKKRRRNTDFFADL-SGAPRRDAITGDEEEEDELEDELMDEDEDEEEKEEVRVLPFIF-----IFWLT------GLSGPVL-WLQNCLNRAADDREEDGVSHPVPLVPLTEENEDAMENKSFQRLLRKVGIRAPADEQES-FWRIPATLSIYQLRVLATSLNPLKENEVGGPA 1061
BLAST of Timeless circadian clock vs. Ensembl Sea Lamprey
Match: timeless (timeless circadian clock [Source:ZFIN;Acc:ZDB-GENE-030131-8978]) HSP 1 Score: 269.24 bits (687), Expect = 1.856e-74 Identity = 288/978 (29.45%), Postives = 469/978 (47.96%), Query Frame = 1
Query: 163 SLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLD---SKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQS-AEFMDTLKSSNSTESASDQ---QLRRQREL-----ELMAKSAENPRVKRFGGTFELQDIKTESGRPAIYH----------HDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAM-IYIDNSKTKESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIK-SRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEED---RIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDN------NPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIE---SRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP-WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
+++D++R LRRE + +IR +LG +++N L+ LL ++ND VLF +IRLL+NLTQP+ + F + +P D ++ V LQ K F + VLS + ++ EWE R E++ LL+ER+L+L+RN++H+ D + +D S HD ++ + SG DLL +L +A +E+++ H LEI+ LMFR Q+ ++ + T + E +D +L RQREL + +S+ R RF GT+ +Q K+ S ++H HDI ++ +R+ K ++ E +S V L+ FC FL YN LM + L ++ Q +DE+YY+WAL FFME R PE VSET+ + FH++ + Y K+ A+ R++HL + AY+EL+ +D +EE R IK +FY EY E++ L F KQ R+FLR L+E + +++LQ V +K R KR+K +++A PS + W ++ + L++ G +P D +P + SE PV+ Q +A +Q L + AV + +++WPE + + +T +D E+++L+ I A KL E + E E ++E++ +V V E F+F+ +I+ F V+ L N TN+ ++ I+H + +L+QL F F L DP ++ + + I E +N K +E+LF K+ HE GY ++ D P+ WT+E + EL +LF E Q D + G V++ D +TR+QI+ +LV GL++S+KELK +K W +++ L L EE + I+ L A RSR V K+L +GLV ++ QL
Sbjct: 2 TVKDLIRFLRREDDSKDIRQQLGDAMILQNDLVPLLLYHHNDQVLFQAIIRLLVNLTQPAIVLFGK-VPTDPTTRHHYLAVTCHLQAYKQAFANEKVFTVLSETLYNLLQLEWEQRQEEDTLLIERMLLLVRNVMHV---PPDPTLEKNVDDDASLHDRVLWALHMSGMDDLLRFLCSAPSEQQWCMHVLEIVCLMFRMQTPSQLVSTGGARPEREKEADTTELELLRQRELAEKRNRMWHRSS---RHSRFVGTYVVQGHKSISDNDLVFHLGVQKLAGYSHDIG---------KEPQRRPKRRLLAPEAEERRRSAMNVRLFLRTFCIDFLDACYNRLMYSVKDTLLLEKGQQNDESYYMWALAFFMEFNRLRGFRPELVSETVGVRTFHFIEKNLTNCYEMMLMEKKDALPWSRRMHLALKAYQELIMTLEEMDKSKEESVRESGNVIKCGNLFYVMEYRELFVTLFRKFDETKQPRSFLRDLVETTHTFLRLLQRFCRGRKAVVVQKKRVKRKKKSRAQAQ-----------PSSSERSPEECEAQWQQLSQQLIAYAQGAEAVP-------DSAVP-----FDAASEVPVEEQRGQATARIQAALLAGQAGTAVGLLRSAREVWPEGEVFGAVGITPED-----ELELLRQIHAA----------KLPFEDVPVEDDVGPEEMEEEENEEVEAVSVSEKEFNFTEYIKRFASAPVMKACMSLLRGYRENSAHTNHCIVVILHRVTVGLHMEGLLFQLSAFRVFQAILADPAAHVYQELSKFARHIVRKFF--EVAAQNNKSFVELLFWKSPANVHEMTEGYGSAHDGGGLSKKGPR-WTEEEQTELDKLFSEFQ--DQIGGSQDKDVVDHIMEHIRDATRTRKQIVAQLVRQGLVNSSKELKRRKGVKLVLWREEQEMELQRLFEEFHKSDDLLDNIVRNLTAK-------RSRKKVADKLLSMGLVSDRAQL 913 HSP 2 Score: 54.299 bits (129), Expect = 2.150e-7 Identity = 28/83 (33.73%), Postives = 43/83 (51.81%), Query Frame = 1
Query: 3226 WFVETLEDNIDSRA-NGIVGPLAIVPLREHDSEILENKLLQRLLYICEFLYPDQSKGHLFWRIPEEMTAKELEYFKNCVTSLT 3471
W L D R +GI P+ +VPL E + + +EN++ +RLL P + FWRIP E+T L +C+++LT
Sbjct: 990 WLGNCLRRTADDREEDGISLPVPLVPLSEENEDAMENRVFRRLLRALGVCSPANHE-ETFWRIPAELTPSRLREISDCLSALT 1071
BLAST of Timeless circadian clock vs. Ensembl Nematostella
Match: EDO48937 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHY6]) HSP 1 Score: 348.591 bits (893), Expect = 3.811e-101 Identity = 301/986 (30.53%), Postives = 516/986 (52.33%), Query Frame = 1
Query: 70 MEKYLSDLHAC-ITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLK-LYNNDSVLFDLVIRLLMNLTQPSYICFKQ-ELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFM----DTLKSSNSTESASDQQLRRQRELELMAKSAE--NPRVKRFGGTFELQDIKT-ESGRPAIYHHDINWSK-IDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDN-SKTKESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSE-PVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKA-SVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNPWTADEQARLIILVEESRDQPIPIKE-IMNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQL 2982
M +YL+ C + LG E ++ K D + SL+D+++ LRR+ CEIR +LG KV+EN LI+++K + +FD+VIRL++NLTQP+ +CF+ ++P+D G ++++ LQ K F D++ + V+ ++S K+W+DR E+++LL+ER+L+L+RNILH+ N + S HD +V + ++G DLL+Y++++ +E R+ HTLEIISLM REQ+ E + D+ S +E + R+REL K+A+ + R RFGGTF + ++ + R IYHH + +K + R++ RK KNQ+ KE T +ST + LQ FC+ FL+ YN L+ L ++ Q +DE+Y+LWA++FFME R + V ET+++ F +V + M Y D+ + K++ V+ R+LHL + AYKELL + L ++ +E R+ + IK+ +FY EY +++ L+ F KQS+A+LR L+E + +K+L+D+ V +++K K+K + Q + + +EQ D +W M L S + G ++ +PE + S+ P+D Q AL +Q +L+ E++A+ +++WP D D D E+E L DI +K DL + +++ +E L+ + S+ + P +F + R C P+++ + L N TN+ L++++H +A K +++QL LF FN+ L DP ++ ++K + KF +I+ F E + KN L +E+ K +E GY + + + + + + G D I D +TRRQI+N+L LGL++ + + + W ADE+ +L + EE + I E I++ L T+ RSR V+ +++++GLVE++ L
Sbjct: 1 MNQYLNTEIVCTLAGLGCAEGTEYYKSPDCLESLKDLIKFLRRDDSTCEIRRQLGNSKVLENDLIAIVKSCTPKEQDIFDMVIRLMVNLTQPAALCFEHGKIPEDKTGQHYYLELVNQLQSYKEAFTDKEAMAVIGRELSRTLQKDWDDRQEEDYLLIERVLLLIRNILHVPANPQAEKRTDDDASIHDQVVWGLHQNGVDDLLLYIASSPDERRWCMHTLEIISLMLREQNPESLARAGDSRSKSEKSEDVRQLETIRERELAEKKKNAKKFSGRHSRFGGTFYINNMMSIADKRQMIYHHSVADAKNLTFDREKSAPRKRKNQIIAKEMTVERRSTLSIRLFLQGFCKQFLEHCYNPLLYVVRDNLMHERSQENDESYFLWAMKFFMEFTRHFDFRVDFVGETMSVSNFQYVLKILMQYYDSFVEDKQNPVTWGRRLHLAVQAYKELLMYVLFMEKSNDETLRSNAKVIKANIFYMVEYRDVFLFLVRKFDKSKQSKAYLRDLVETFHVFLKMLEDYCSGKSHIV----IQQKKKKKKTKKRKSKQAPARVNLSAEQAD------EMWQAMASELSSWIQG-----------HNGTIPESVVPFDAASDIPIDQQRVSALSRIQTQLQNCEYGESIALLRAAREVWP-NDSFGAADGDP--EDEFMCLHDI------FKMTDLPIETTPLADAEAEVNEEEILQLVESKFISLSCWKFP-NFLSYSRLAC-PSILQPYCWLLGFYRENSAKTNHYLVKMLHRVAVDLKIVPMMFQLSLFVTFNRVLHDPAAS--QYKEMVKFARYILGNFFEMLPKNPVLCVELSTWKTTDACYEISEGYGSLQNRRSLKKSGATWSYEEEEELKSLYHQYQEGEDDVIDKILDNLQDDTRTRRQIINKLFLLGLVTDKRAFRKPAAKKGAWGADEEEQLRAVYEEYKQSDGDIVEKILSHLTNTS------RSRRQVVNQLVKMGLVEDRKTL 946
BLAST of Timeless circadian clock vs. Ensembl Medaka
Match: timeless (timeless circadian regulator [Source:NCBI gene;Acc:101171325]) HSP 1 Score: 327.791 bits (839), Expect = 8.783e-93 Identity = 303/967 (31.33%), Postives = 503/967 (52.02%), Query Frame = 1
Query: 97 ACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASD-----QQLRRQRELELMAKSAE-NPRVKRFGGTFELQDIKTESGRPAIYHHDINWSKIDLTRD--RKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLV 2964
A + LG E + K+ D + S++D++R+LR E + ++R +LG ++++N L+ L+ + D LFD IRL++NLTQP+ +CF + +P D V F++V LQ K F +LS + + +WE R E+++LL+ERIL+L+RNILH+ + + + S HD ++ + SG+ DL+ +L++A++E++++ H LEIISLMFR+Q+AE + + S S E + LR++ E +++ + R RFGG F +Q +K + IYH ++ K T D + +RR K E +S V L+EFC FL+ YN LM L R+Q Q DETYYLWAL FFM R N + VSET++I FH++ + Y + T ++ A S R++HL + AY+ELL +D +E R S +KS +FY E+ EI+ LL + KQ +L+ L+E + L +++L+ + V ++R K N++ Q++ + L W +++E + A ++ L +I P + I P++ Q A+ VQ L EA+A+ +++WP D + D EEE+++LK+I+ AN L + +E +VEE+++ +E ++E++ S+QV E F+F FI+ F +P++V + ++ N P TN+ ++R++H +A K +L+QL +F+ FNK L DP + + + +N K +E+LF KN+ E GYS + W++E EEEL +L+ E + D+ P D + S+ ++TRRQ++ +LV +GL+ +AKELK +K+ WT D++ L +L EE +D + IM L A RSR V+ K+L +GLV
Sbjct: 7 ATCSALGYLEGDNYHKETDCLESVKDLIRYLRHEDDSRDVRRQLGASQILQNDLLPLIVQFRQDKTLFDACIRLMVNLTQPAVLCFGK-VPDDPVFTHHFMEVTSHLQAYKEAFASERVFGILSETLYNFLQLDWEQRQEEDNLLIERILLLVRNILHVPADPCEEKKVDDDASIHDKVLWAIHMSGFDDLVKFLASAQSEQQWSMHVLEIISLMFRDQTAELLVSAGHSRSAEEKQRDLQELEALRQKENAEKRSRTLQRGTRHSRFGGCFVVQGLKAIGDKDVIYHRRLHKFK-SYTHDEGKAVRRVPKRNQRASECKEQRRSALNVRLFLREFCVDFLENCYNRLMYLVKENLIREQSQQHDETYYLWALSFFMAFNRGNNFRADLVSETMSIRAFHFIERNITNYYEMLLTDRKEATSWSRRMHLALKAYQELLLTVNEMDRSHDEGIRQSSNVLKSNIFYMMEFREIFLTLLRKYDETKQPGTYLKDLVETTHLFLRMLERFCKGRKNLV----VQRKRVKRKKSHNRKKQSVA--------ETSPEALAETW-KIVEEELRASGFQLSESLTGSII--PF--DATSKI-----PLEEQRIEAMVRVQDALLAHTGPEALALLRAAREVWP--DGNVFGSPDVEPEEELELLKEILHAN----------LPRSTAET-LVEEEDDGIEFEEEELESIQVSETEFNFKDFIKKFANPSIVRPYILMLRTYSKNTPHTNHCVVRMLHRLAVDLKMDALLFQLSVFHLFNKILSDPAAEAYKELVTFAKFVVNRFFSV--AAQNNKAFVELLFWKNVGAVREMTEGYSKDGEGKKPAWSEEEEEELRKLYMEHRDSDV-P--DIVETLLPLLSNSSRTRRQVVTQLVRMGLVDNAKELKKQKKGTGIVLWTEDQEEELQMLFEEFKDSEDVLGNIMKKLTAK-------RSRARVVDKLLSMGLV 924
BLAST of Timeless circadian clock vs. Ensembl Medaka
Match: timeless (timeless circadian regulator [Source:NCBI gene;Acc:101171325]) HSP 1 Score: 249.595 bits (636), Expect = 3.992e-67 Identity = 175/505 (34.65%), Postives = 281/505 (55.64%), Query Frame = 1
Query: 97 ACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASD-----QQLRRQRELELMAKSAE-NPRVKRFGGTFELQDIKTESGRPAIYHHDINWSKIDLTRD--RKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKT-KESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQ 1584
A + LG E + K+ D + S++D++R+LR E + ++R +LG ++++N L+ L+ + D LFD IRL++NLTQP+ +CF + +P D V F++V LQ K F +LS + + +WE R E+++LL+ERIL+L+RNILH+ + + + S HD ++ + SG+ DL+ +L++A++E++++ H LEIISLMFR+Q+AE + + S S E + LR++ E +++ + R RFGG F +Q +K + IYH ++ K T D + +RR K E +S V L+EFC FL+ YN LM L R+Q Q DETYYLWAL FFM R N + VSET++I FH++ + Y + T ++ A S R++HL + AY+ELL +D +E R S +KS +FY E+ EI+ LL + KQ +L+ L+E + L +++L+
Sbjct: 14 ATCSALGYLEGDNYHKETDCLESVKDLIRYLRHEDDSRDVRRQLGASQILQNDLLPLIVQFRQDKTLFDACIRLMVNLTQPAVLCFGK-VPDDPVFTHHFMEVTSHLQAYKEAFASERVFGILSETLYNFLQLDWEQRQEEDNLLIERILLLVRNILHVPADPCEEKKVDDDASIHDKVLWAIHMSGFDDLVKFLASAQSEQQWSMHVLEIISLMFRDQTAELLVSAGHSRSAEEKQRDLQELEALRQKENAEKRSRTLQRGTRHSRFGGCFVVQGLKAIGDKDVIYHRRLHKFK-SYTHDEGKAVRRVPKRNQRASECKEQRRSALNVRLFLREFCVDFLENCYNRLMYLVKENLIREQSQQHDETYYLWALSFFMAFNRGNNFRADLVSETMSIRAFHFIERNITNYYEMLLTDRKEATSWSRRMHLALKAYQELLLTVNEMDRSHDEGIRQSSNVLKSNIFYMMEFREIFLTLLRKYDETKQPGTYLKDLVETTHLFLRMLE 516 HSP 2 Score: 99.7525 bits (247), Expect = 1.215e-20 Identity = 88/274 (32.12%), Postives = 141/274 (51.46%), Query Frame = 1
Query: 2170 SVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSN------SDDNNPK-EWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNKKRENNP--WTADEQARLIILVEESRDQPIPIKEIMNGLKATAVDPDKLRSRGSVIKKILELGLV 2964
S+QV E F+F FI+ F +P++V + ++ N P TN+ ++R++H +A K +L+QL +F+ FNK L DP + + + +N K +E+LF KN+ E GYS S+ N K W++E EEEL +L+ E + D+ + S+ ++TRRQ++ +LV +GL+ +AKELK +K+ WT D++ L +L EE +D + IM L A RSR V+ K+L +GLV
Sbjct: 672 SIQVSETEFNFKDFIKKFANPSIVRPYILMLRTYSKNTPHTNHCVVRMLHRLAVDLKMDALLFQLSVFHLFNKILSDPAAEAYKELVTFAKFVVNRFFSV--AAQNNKAFVELLFWKNVGAVREMTEGYSKDGCVRASERNGKKPAWSEEEEEELRKLYMEHRDSDV-------ETLLPLLSNSSRTRRQVVTQLVRMGLVDNAKELKKQKKGTGIVLWTEDQEEELQMLFEEFKDSEDVLGNIMKKLTAK-------RSRARVVDKLLSMGLV 929
BLAST of Timeless circadian clock vs. Planmine SMEST
Match: SMESG000030307.1 (SMESG000030307.1) HSP 1 Score: 1641.71 bits (4250), Expect = 0.000e+0 Identity = 899/903 (99.56%), Postives = 901/903 (99.78%), Query Frame = 1
Query: 70 MEKYLSDLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFREQSAEFMDTLKSSNSTESASDQQLRRQRELELMAKSAENPRVKRFGGTFELQDIKTESGRPAIYHHDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGXXXXXXXXXXXXXXANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVXXXXXXXXXXXXXINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQXXXXXXXXXXXXDPLSNNPEXXXXXXXXXXXXXXXTENVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDXXXXXXXXXXXXXQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNK 2778
MEKYLSDLHACITCLGITENKQFLKDVDTI SLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDEHLLVERILILLRNILHINTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFR+QSAEFM TLKSSNSTESASDQQLRRQRELELMAKSAENPRVKRFGGTFELQDIKTESGRPAIYHHDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGKKSRTKRRKSIKSKANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVEEDENELETDDEDINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQLKLFNGFNKFLLDPLSNNPEFKALKKFVIFIIKKFTE+VNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDELEEELVRLFEEVQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNK
Sbjct: 1 MEKYLSDLHACITCLGITENKQFLKDVDTIVSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDEHLLVERILILLRNILHINTNKSDGIIANGLDSKHDNLVMHMMESGWKDLLIYLSNAENEERFTFHTLEIISLMFRDQSAEFMGTLKSSNSTESASDQQLRRQRELELMAKSAENPRVKRFGGTFELQDIKTESGRPAIYHHDINWSKIDLTRDRKLRRKAKNQVHNKEETYIHKSTDKVLNALQEFCQIFLQIGYNCLMKNALSMLQRQQMQADDETYYLWALRFFMEVCRRNKLSPESVSETITIPVFHWVYQQAMIYIDNSKTKESAVSSYRKLHLVMSAYKELLEFCLMLDNHQEEKYRTLSASIKSRVFYSSEYIEIYPMLLSHFKPIKQSRAFLRTLIEGSFLIIKILQDHNEFGMKFVGKKSRTKRRKSIKSKANQENQNIGTMEIPSEQDDGGNVLRGIWDEMLETLMSAVNGEVELPLNLPVIYDPLLPECRESIEPDSEPVDSQLKRALGLVQIRLRQRNSIEAVAIFELCQKLWPEEDRIMVTDDDNRVEEEIKILKDIMFANKFYKEEDLIKLSKEISEIGVVEEDENELETDDEDINSVQVREVPFDFSRFIRSFCHPNVVNTFGVLFEDIITNPPSTNNRLLRIMHIIAEKTKQPYVLYQLKLFNGFNKFLLDPLSNNPEFKALKKFVIFIIKKFTEHVNKNRKLLLEVLFSKNIHEAHETVYGYSNSDDNNPKEWTDELEEELVRLFEEVQHEDILPGFDKASVIESRFSDKNKTRRQILNRLVTLGLISSAKELKNK 903
BLAST of Timeless circadian clock vs. Planmine SMEST
Match: SMESG000030309.1 (SMESG000030309.1) HSP 1 Score: 445.662 bits (1145), Expect = 4.232e-174 Identity = 265/267 (99.25%), Postives = 267/267 (100.00%), Query Frame = 1
Query: 2875 MNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKNSKLIPNYDSGSXXXXXXXXXXXXXXXXXXSRFMNDLFHQSLSSIKRNPPALKVKRKIDWDTLKIIYAQLDTKVQEWFVETLEDNIDSRANGIVGPLAIVPLREHDSEILENKLLQRLLYICEFLYPDQSKGHLFWRIPEEMTAKELEYFKNCVTSLTESELEALAMENVNDQSLNDQNQDLFSSKYKDXXXXXXXXXXXXGSENISPXXXXXXXXXXXXXIPVQT 3675
MNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKNSKLIPNYDSGSDDNEREPENNEDDEEE+ESRFMNDLFHQSLSSIKRNPPALKVKRKI+WDTLKIIYAQLDTKVQEWFVETLEDNIDSRANGIVGPLAIVPLREHDSEILENKLLQRLLYICEFLYPDQSKGHLFWRIPEEMTAKELEYFKNCVTSLTESELEALAMENVNDQSLNDQNQDLFSSKYKDINNENQIVNNVNGSENISPLSSDDDDDLDDMDIPVQT
Sbjct: 1 MNGLKATAVDPDKLRSRGSVIKKILELGLVENKDQLGIRDKNSKLIPNYDSGSDDNEREPENNEDDEEEDESRFMNDLFHQSLSSIKRNPPALKVKRKINWDTLKIIYAQLDTKVQEWFVETLEDNIDSRANGIVGPLAIVPLREHDSEILENKLLQRLLYICEFLYPDQSKGHLFWRIPEEMTAKELEYFKNCVTSLTESELEALAMENVNDQSLNDQNQDLFSSKYKDINNENQIVNNVNGSENISPLSSDDDDDLDDMDIPVQT 267 HSP 2 Score: 187.578 bits (475), Expect = 4.232e-174 Identity = 109/109 (100.00%), Postives = 109/109 (100.00%), Query Frame = 3
Query: 3723 KSKIRRLISDDEEDENTQRAIINSKSFETILSDTANTKNVFKNTKNSFDMFMSDEDEVDPMKNANLMDNSIEDRENIHKKTKRIFXXXXXXXXXXXNRKKRVKVLDDDS 4049
KSKIRRLISDDEEDENTQRAIINSKSFETILSDTANTKNVFKNTKNSFDMFMSDEDEVDPMKNANLMDNSIEDRENIHKKTKRIFEDSDEEDEIISNRKKRVKVLDDDS
Sbjct: 268 KSKIRRLISDDEEDENTQRAIINSKSFETILSDTANTKNVFKNTKNSFDMFMSDEDEVDPMKNANLMDNSIEDRENIHKKTKRIFEDSDEEDEIISNRKKRVKVLDDDS 376
BLAST of Timeless circadian clock vs. Planmine SMEST
Match: SMESG000030310.1 (SMESG000030310.1) HSP 1 Score: 304.679 bits (779), Expect = 2.203e-95 Identity = 171/177 (96.61%), Postives = 174/177 (98.31%), Query Frame = 1
Query: 70 MEKYLSDLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGII 600
MEKYLSDLHACI CLGITEN+QFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLT+PSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFID DFLEVLSSKISDIYLKEWEDRSEDEHLLVERILIL+RNILHIN NKSDGII
Sbjct: 1 MEKYLSDLHACIICLGITENEQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTKPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDIDFLEVLSSKISDIYLKEWEDRSEDEHLLVERILILMRNILHINANKSDGII 177
BLAST of Timeless circadian clock vs. Planmine SMEST
Match: SMESG000030310.1 (SMESG000030310.1) HSP 1 Score: 303.908 bits (777), Expect = 3.311e-95 Identity = 170/179 (94.97%), Postives = 176/179 (98.32%), Query Frame = 1
Query: 70 MEKYLSDLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTQPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDRDFLEVLSSKISDIYLKEWEDRSEDXXXXXXXXXXXXXXXXXXXTNKSDGIIAN 606
MEKYLSDLHACI CLGITEN+QFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLT+PSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFID DFLEVLSSKISDIYLKEWEDRSEDEHLLVERILIL+RNILHIN NKSDGI+++
Sbjct: 1 MEKYLSDLHACIICLGITENEQFLKDVDTIFSLRDILRHLRRETEKCEIRLELGKFKVIENCLISLLKLYNNDSVLFDLVIRLLMNLTKPSYICFKQELPKDLVGMEIFIKVDEMLQRCKSHFIDIDFLEVLSSKISDIYLKEWEDRSEDEHLLVERILILMRNILHINANKSDGIVSD 179 The following BLAST results are available for this feature:
BLAST of Timeless circadian clock vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 2
BLAST of Timeless circadian clock vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 2
BLAST of Timeless circadian clock vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Timeless circadian clock vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 4
BLAST of Timeless circadian clock vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Timeless circadian clock vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Timeless circadian clock vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Timeless circadian clock vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Timeless circadian clock vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 4
BLAST of Timeless circadian clock vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Timeless circadian clock vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Timeless circadian clock vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Timeless circadian clock vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 2
BLAST of Timeless circadian clock vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017903 ID=SMED30017903|Name=Timeless circadian clock|organism=Schmidtea mediterranea sexual|type=transcript|length=4060bpback to top protein sequence of SMED30017903-orf-1 >SMED30017903-orf-1 ID=SMED30017903-orf-1|Name=SMED30017903-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1208bp MEKYLSDLHACITCLGITENKQFLKDVDTIFSLRDILRHLRRETEKCEIRback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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