Protein kinase domain-containing protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017847 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 10
Homology
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: DSTYK (dual serine/threonine and tyrosine protein kinase [Source:HGNC Symbol;Acc:HGNC:29043]) HSP 1 Score: 199.904 bits (507), Expect = 3.798e-52 Identity = 156/536 (29.10%), Postives = 260/536 (48.51%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDE-IGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTE-----GHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
RK E EL+E + + + + ++ ++E L E +++ ++E+ + I VPENG + R I+ C Q +I+S L Q + N + V+ L + + +E + S K + + VH + SNY L A + E G +V L ++I I+ S + EWK + A+E ++ S LA+ +C + H AF +L ++ +E++ ++ + AP A L + + ++ + + + +++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D I++ + + D+ LK ++++ RL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F R S LW + RPERL +E W+LM+ACWD +P RP
Sbjct: 395 RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDATNMEFKDVI-VPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDY-LRESFVGTLERCLQSLEKSQDVSVH-----------------ITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRI---------TWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAG-LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASK--DHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRP 897
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: DSTYK (dual serine/threonine and tyrosine protein kinase [Source:HGNC Symbol;Acc:HGNC:29043]) HSP 1 Score: 153.295 bits (386), Expect = 2.306e-37 Identity = 141/535 (26.36%), Postives = 237/535 (44.30%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDE-IGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTE-----GHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
RK E EL+E + + + + ++ ++E L E +++ ++E+ + I VPENG + R I+ C Q +I+S L Q + N + V+ L + + +E + S K + + VH + SNY L A + E G +V L ++I I+ S + EWK + A+E ++ S LA+ +C + H AF +L ++ +E++ ++ + AP A L + + ++ + + + +++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D I++ + + D+ LK ++++ RL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ A RPERL +E W+LM+ACWD +P RP
Sbjct: 395 RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDATNMEFKDVI-VPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDY-LRESFVGTLERCLQSLEKSQDVSVH-----------------ITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRI---------TWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAG-LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGA-----------------------------------------------RPERLPVFDEECWQLMEACWDGDPLKRP 852
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: NEK7 (NIMA related kinase 7 [Source:HGNC Symbol;Acc:HGNC:13386]) HSP 1 Score: 106.301 bits (264), Expect = 2.418e-24 Identity = 87/298 (29.19%), Postives = 141/298 (47.32%), Query Frame = 2
Query: 1991 VSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSC--NGQEMAKKTVN----LPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVS---KYLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESV 2839
+ E+ + P F L D+ G L + +KIG+G EVYR +C +G +A K V + D +E+ HP ++ A I D+ +++I L D+S K+ K+ K I ER K +Q+ AL+++H +++MHRD+K AN+ + V L D G F S + HS VGTP +++PE + + Y+FK DI+S G LL+ +A F + N+ + + + P D S+EL +L+ C + +P RPD+ V
Sbjct: 1 MDEQSQGMQGPPVPQFQPQKALRPDM-GYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDN------ELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: NEK7 (NIMA related kinase 7 [Source:HGNC Symbol;Acc:HGNC:13386]) HSP 1 Score: 106.301 bits (264), Expect = 2.418e-24 Identity = 87/298 (29.19%), Postives = 141/298 (47.32%), Query Frame = 2
Query: 1991 VSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSC--NGQEMAKKTVN----LPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVS---KYLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESV 2839
+ E+ + P F L D+ G L + +KIG+G EVYR +C +G +A K V + D +E+ HP ++ A I D+ +++I L D+S K+ K+ K I ER K +Q+ AL+++H +++MHRD+K AN+ + V L D G F S + HS VGTP +++PE + + Y+FK DI+S G LL+ +A F + N+ + + + P D S+EL +L+ C + +P RPD+ V
Sbjct: 1 MDEQSQGMQGPPVPQFQPQKALRPDM-GYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDN------ELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: NEK6 (NIMA related kinase 6 [Source:HGNC Symbol;Acc:HGNC:7749]) HSP 1 Score: 100.138 bits (248), Expect = 3.543e-22 Identity = 81/273 (29.67%), Postives = 132/273 (48.35%), Query Frame = 2
Query: 2075 RYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQL---------NDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVS---KYLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESV 2839
R L + +KIG+G EVY+ +C + +KTV L Q+ D +E+ HP ++ + I D+ +++I L D+S KY K+ K I ER K +Q+ A++++H +++MHRD+K AN+ + V L D G F S + HS VGTP +++PE + + Y+FK DI+S G LL+ +A F + N+ + + + P + S++L EL+ C +P RPDI V
Sbjct: 39 RCSLADFQIEKKIGRGQFSEVYKATC---LLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDN------ELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYV 299
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: frk-1 (Fer-related kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:Q22146]) HSP 1 Score: 102.064 bits (253), Expect = 1.023e-22 Identity = 80/342 (23.39%), Postives = 166/342 (48.54%), Query Frame = 2
Query: 1883 LAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFA--GLLMLTLDVKGRYMLQ--GIVVNEKIGQGAQGEVYRCSCN---GQEMAKKTVNLPMNQLNDI--AEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSM-ALSNHSFVGTPVH-IAPEIVRKAIYDFKVDIYSYGMLLWYL-AEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQA-CWDNEPSVRPDIESVLCKITLILEN 2869
+ +E+C+ + + + N F + H++ ++SE I M K P A G + + +++ IV N+K+G+GA G+V+ + QE+A KT+ + + +E +QH ++ LI V+I + + + L+ +LK+NKVS+ E+L+ + A+ + YL R + +HRD+ N LL N + ++D+G + + + + P+ +APE +++ +Y K DI+++G+L+W + ++G +P ++Q+ V+ ++ R + D + +++ CW P R ++S+ K+ E+
Sbjct: 63 VTDELCRHFMLNMDPTSNKFYF------EHTHQESTISELINWHMTTKTPISAASGAKIRRPMERSPWLINHDSIVANKKLGEGAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLMIVMEYCPNGSLLS-----HLKKNKVSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNELKISDFGMSDNKDEIKDETLEKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIYSDGAEPYPGLTKIQTRAKIVV-----NDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKLREFYES 388
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: svh-2 (Tyrosine-protein kinase receptor svh-2 [Source:UniProtKB/Swiss-Prot;Acc:H2KZU7]) HSP 1 Score: 102.064 bits (253), Expect = 1.011e-21 Identity = 68/265 (25.66%), Postives = 131/265 (49.43%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRCSCNGQEMAKKTV---NLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKR--NKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFV-----GTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELW-ELMQACWDNEPSVRPDIESVLCKITLILE 2866
+ IGQG G VY+ + + ++ V L ++++ EE F HP +L LI V++ DS+ L I I + K D+ +++ N + +++ + A +A+ + Y+H ++ +HRDL N LLD++ V +AD+G C+ + + +V PV P + + + DI+S+G+++W L G P ++ + S I + W R + ++L+ ++M ACW P+ RP ++ I +++
Sbjct: 739 DPIGQGHYGVVYKAMYSPSKSLEEKVVCKYLKEGKISEFYEEARTMSEFDHPNILKLIGVALDDSSHL---PIIITEYMAKGDLKSFIENVENTIKMRDLFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKVDIETELYVQMHERDLPVRWFPPEISEQGFGITSDIWSFGVVIWELFT-RGSTP-YSNMASWILILPWLKESETNRLRKPPYCPEKLYTDVMLACWKANPAERPQFSDLVTIIPNVVK 998
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: svh-2 (Tyrosine-protein kinase receptor svh-2 [Source:UniProtKB/Swiss-Prot;Acc:H2KZU7]) HSP 1 Score: 102.064 bits (253), Expect = 1.011e-21 Identity = 68/265 (25.66%), Postives = 131/265 (49.43%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRCSCNGQEMAKKTV---NLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKR--NKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFV-----GTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELW-ELMQACWDNEPSVRPDIESVLCKITLILE 2866
+ IGQG G VY+ + + ++ V L ++++ EE F HP +L LI V++ DS+ L I I + K D+ +++ N + +++ + A +A+ + Y+H ++ +HRDL N LLD++ V +AD+G C+ + + +V PV P + + + DI+S+G+++W L G P ++ + S I + W R + ++L+ ++M ACW P+ RP ++ I +++
Sbjct: 739 DPIGQGHYGVVYKAMYSPSKSLEEKVVCKYLKEGKISEFYEEARTMSEFDHPNILKLIGVALDDSSHL---PIIITEYMAKGDLKSFIENVENTIKMRDLFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKVDIETELYVQMHERDLPVRWFPPEISEQGFGITSDIWSFGVVIWELFT-RGSTP-YSNMASWILILPWLKESETNRLRKPPYCPEKLYTDVMLACWKANPAERPQFSDLVTIIPNVVK 998
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: svh-2 (Tyrosine-protein kinase receptor svh-2 [Source:UniProtKB/Swiss-Prot;Acc:H2KZU7]) HSP 1 Score: 102.064 bits (253), Expect = 1.179e-21 Identity = 68/265 (25.66%), Postives = 131/265 (49.43%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRCSCNGQEMAKKTV---NLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKR--NKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFV-----GTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELW-ELMQACWDNEPSVRPDIESVLCKITLILE 2866
+ IGQG G VY+ + + ++ V L ++++ EE F HP +L LI V++ DS+ L I I + K D+ +++ N + +++ + A +A+ + Y+H ++ +HRDL N LLD++ V +AD+G C+ + + +V PV P + + + DI+S+G+++W L G P ++ + S I + W R + ++L+ ++M ACW P+ RP ++ I +++
Sbjct: 739 DPIGQGHYGVVYKAMYSPSKSLEEKVVCKYLKEGKISEFYEEARTMSEFDHPNILKLIGVALDDSSHL---PIIITEYMAKGDLKSFIENVENTIKMRDLFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKVDIETELYVQMHERDLPVRWFPPEISEQGFGITSDIWSFGVVIWELFT-RGSTP-YSNMASWILILPWLKESETNRLRKPPYCPEKLYTDVMLACWKANPAERPQFSDLVTIIPNVVK 998
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: svh-2 (Tyrosine-protein kinase receptor svh-2 [Source:UniProtKB/Swiss-Prot;Acc:H2KZU7]) HSP 1 Score: 101.679 bits (252), Expect = 1.368e-21 Identity = 68/265 (25.66%), Postives = 131/265 (49.43%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRCSCNGQEMAKKTV---NLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKR--NKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFV-----GTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELW-ELMQACWDNEPSVRPDIESVLCKITLILE 2866
+ IGQG G VY+ + + ++ V L ++++ EE F HP +L LI V++ DS+ L I I + K D+ +++ N + +++ + A +A+ + Y+H ++ +HRDL N LLD++ V +AD+G C+ + + +V PV P + + + DI+S+G+++W L G P ++ + S I + W R + ++L+ ++M ACW P+ RP ++ I +++
Sbjct: 739 DPIGQGHYGVVYKAMYSPSKSLEEKVVCKYLKEGKISEFYEEARTMSEFDHPNILKLIGVALDDSSHL---PIIITEYMAKGDLKSFIENVENTIKMRDLFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKVDIETELYVQMHERDLPVRWFPPEISEQGFGITSDIWSFGVVIWELFT-RGSTP-YSNMASWILILPWLKESETNRLRKPPYCPEKLYTDVMLACWKANPAERPQFSDLVTIIPNVVK 998
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0090002) HSP 1 Score: 89.3521 bits (220), Expect = 2.174e-18 Identity = 78/270 (28.89%), Postives = 131/270 (48.52%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRC--SCNGQEMAKKTVNL----------PMNQLNDIAEEV-YYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRN-KVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSM----ALSNHSFVGTPVHIAPEIVR------KAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVL 2842
E +G+G V RC G+E A K ++L P + L +E+ + HP + + + D E D+ +F K ++ YL +S K+ I Q+ E ++Y+H + I+HRDLK NILLD+N+NV + D+GF K + L+N GTP ++APE ++ Y +VDI++ G++++ L G P + R Q + + + PE D IS++ +L++ C +PS R ++ VL
Sbjct: 27 EILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYI-----IDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTN--LCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGC--PPFWHRKQMVMLRNIMEGKYSFTSPEWAD-ISEDPKDLIRKCLVVDPSQRITVKEVL 286
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0343648) HSP 1 Score: 89.3521 bits (220), Expect = 2.174e-18 Identity = 78/270 (28.89%), Postives = 131/270 (48.52%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRC--SCNGQEMAKKTVNL----------PMNQLNDIAEEV-YYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRN-KVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSM----ALSNHSFVGTPVHIAPEIVR------KAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVL 2842
E +G+G V RC G+E A K ++L P + L +E+ + HP + + + D E D+ +F K ++ YL +S K+ I Q+ E ++Y+H + I+HRDLK NILLD+N+NV + D+GF K + L+N GTP ++APE ++ Y +VDI++ G++++ L G P + R Q + + + PE D IS++ +L++ C +PS R ++ VL
Sbjct: 27 EILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQVMGHPYI-----IDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTN--LCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGC--PPFWHRKQMVMLRNIMEGKYSFTSPEWAD-ISEDPKDLIRKCLVVDPSQRITVKEVL 286
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0343587) HSP 1 Score: 89.3521 bits (220), Expect = 2.188e-18 Identity = 81/272 (29.78%), Postives = 133/272 (48.90%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRC--SCNGQEMAKKTVNL----------PMNQLNDIAEEVYYSYLFQ---HPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRN-KVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSM----ALSNHSFVGTPVHIAPEIVR------KAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVL 2842
E +G+G V RC G+E A K ++L P + L +E+ S L Q HP + + + D E D+ +F K ++ YL +S K+ I Q+ E ++Y+H + I+HRDLK NILLD+N+NV + D+GF K + L+N GTP ++APE ++ Y +VDI++ G++++ L G P + R Q + + + PE D IS++ +L++ C +PS R ++ VL
Sbjct: 27 EILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEI--SILRQVMGHPYI-----IDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTN--LCGTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLL--VGCPPFWHRKQMVMLRNIMEGKYSFTSPEWAD-ISEDPKDLIRKCLVVDPSQRITVKEVL 286
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334539) HSP 1 Score: 91.2781 bits (225), Expect = 2.294e-18 Identity = 74/245 (30.20%), Postives = 119/245 (48.57%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRC--SCNGQEMAKKTVNL---PMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNH---SFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPE--RLDEISDELWELMQACWDNE 2809
EKIGQGA G VY S G E+A K +NL P +L I E+ +HP + V+ DS + + + L ++ + + + + +V +AL++LH Q++HRD+K NILL + +V L D+GFC ++ + VGTP +APE+V + Y KVD++S G++ + EG P + A L A+ N +PE D++S + + C + E
Sbjct: 434 EKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKEL--IINEILVMRENKHPNV-----VNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEG---EPPYLNENPLKALYLIAT---NGKPEIKEKDKLSSAFQDFLDQCLEVE 665
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081714) HSP 1 Score: 91.2781 bits (225), Expect = 2.294e-18 Identity = 74/245 (30.20%), Postives = 119/245 (48.57%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRC--SCNGQEMAKKTVNL---PMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNH---SFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPE--RLDEISDELWELMQACWDNE 2809
EKIGQGA G VY S G E+A K +NL P +L I E+ +HP + V+ DS + + + L ++ + + + + +V +AL++LH Q++HRD+K NILL + +V L D+GFC ++ + VGTP +APE+V + Y KVD++S G++ + EG P + A L A+ N +PE D++S + + C + E
Sbjct: 434 EKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKEL--IINEILVMRENKHPNV-----VNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEG---EPPYLNENPLKALYLIAT---NGKPEIKEKDKLSSAFQDFLDQCLEVE 665
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:402922]) HSP 1 Score: 192.586 bits (488), Expect = 4.339e-50 Identity = 154/547 (28.15%), Postives = 273/547 (49.91%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNS---IKLFF------SKLFGTDQIKESV--------DVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRC-SCNGQE-MAKKTVNLPMNQ-LNDIAEEVYYSY-LFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
R+ E ELF + + + + ++ + ++E L E ++ +L++ + I + NG + + I+ C Q +I++ L Q + N + V+ L + + +E +CLG SLE+ + + HNV +++ILN+ +++ F ++LF +QIK+ + + EWK + A++ ++ + LA+ +C + H AF +L + ++ +E++ ++ + AP A L + + ++ + + ++G+G G VY C S G+ A K+V P ++ ND+A E +Y+ L +H RL+ L S+ D + I++ + + D+ LK +S+KERL IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WYL G+ + P F + S LW + + RPERL +E W+LM+ACW+ +PS RP
Sbjct: 355 REKEGELFCSLMAIANRKQEEMKEMIVETLSSMKEQLLEDAQNLDFTDII-MSSNGEPVSSKDIKVCISQIQDLIVNRLNQAVANKLTNSVDY-LRESFVGTLE----------------RCLG------SLEK------------STPESCAHNVTSNHLKQILNAAYHVEVTFHSGSSVTRLF-WEQIKQIIHRITWVNPPAITAEWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDILLHGKPKLGRELGRGQYGVVYLCDSWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHG-SVIDHSYSGGSSIAVLLIMERLHRDLYTGLKAG-LSLKERLLIALDVVEGIRFLHSQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYLCSGSVKLPEAFEKCASK--DQLWTNVKKGCRPERLPVFDEECWQLMEACWNGDPSQRP 859
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:402922]) HSP 1 Score: 188.734 bits (478), Expect = 5.885e-49 Identity = 147/530 (27.74%), Postives = 259/530 (48.87%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRC-SCNGQE-MAKKTVNLPMNQ-LNDIAEEVYYSY-LFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
R+ E ELF + + + + ++ + ++E L E ++ +L++ + I + NG + + I+ C Q +I++ L Q + N + V+ L + + +E +CLG SLE+ + + HNV +++I++ I + EWK + A++ ++ + LA+ +C + H AF +L + ++ +E++ ++ + AP A L + + ++ + + ++G+G G VY C S G+ A K+V P ++ ND+A E +Y+ L +H RL+ L S+ D + I++ + + D+ LK +S+KERL IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WYL G+ + P F + S LW + + RPERL +E W+LM+ACW+ +PS RP
Sbjct: 355 REKEGELFCSLMAIANRKQEEMKEMIVETLSSMKEQLLEDAQNLDFTDII-MSSNGEPVSSKDIKVCISQIQDLIVNRLNQAVANKLTNSVDY-LRESFVGTLE----------------RCLG------SLEK------------STPESCAHNVTSNHLKQIIHRITWVNPPAI------------TAEWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDILLHGKPKLGRELGRGQYGVVYLCDSWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHG-SVIDHSYSGGSSIAVLLIMERLHRDLYTGLKAG-LSLKERLLIALDVVEGIRFLHSQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYLCSGSVKLPEAFEKCASK--DQLWTNVKKGCRPERLPVFDEECWQLMEACWNGDPSQRP 831
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: nek6 (NIMA-related kinase 6 [Source:ZFIN;Acc:ZDB-GENE-040724-133]) HSP 1 Score: 106.301 bits (264), Expect = 6.635e-25 Identity = 78/265 (29.43%), Postives = 132/265 (49.81%), Query Frame = 2
Query: 2093 IVVNEKIGQGAQGEVYRCSC--NGQEMAKKTVN----LPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVSK---YLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVL 2842
++ +KIG+G EVYR +C N Q++A K V + D +E+ HP ++ + I ++ +++I L D+S+ + K+ + I ER K +Q+ AL+++H +++MHRD+K AN+ + + V L D G F S + HS VGTP +++PE + + Y+FK DI+S G LL+ +A H F + N+ + + P + S + +L+ C + EP RPDI VL
Sbjct: 2 FLIEKKIGRGQFSEVYRATCLLNNQKVALKKVQIFEMMDAKARQDCVKEIDLLKQLNHPNVIKYLDSFIANN------ELNIVLELASAGDLSQMIMHFKKKRRLIPERTIWKYFVQLCSALEHMHSRRVMHRDIKPANVFITASGEVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALHSPFYSDKMNLLSLCHKIEQCEYPPLPTEHYSQKFRDLVSMCINPEPDQRPDISFVL 257
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-070705-183]) HSP 1 Score: 100.523 bits (249), Expect = 1.052e-21 Identity = 71/254 (27.95%), Postives = 123/254 (48.43%), Query Frame = 2
Query: 2084 LQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLM-KTDVSKYLK---RNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCK--SMALSNHSFVGTPVH-IAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
L + + E IG+G G V+ GQ +A K + + EE H L+PL+ V + + + I LM K ++ +L+ R VS+ + L+ AL V E +++L ++++HRDL NIL+ ++ ++D+G + SMA+ N PV APE ++ + + D++SYG+LLW + GR P + + + + E R + DE +++ +M +CW EP RP
Sbjct: 187 LSKLTLGEIIGEGEFGAVFAGEYTGQRVAVKIIKCDVTA-QAFLEETSVMTNLHHKNLVPLLGVILHNG-------LHIVTELMTKGNLVNFLRSRGRFAVSVIQLLRFALDVCEGMEHLESKKLLHRDLAGRNILVSEDGVAKISDFGLARVGSMAVDNSKL---PVKWTAPEALKNKKFSTQSDVWSYGVLLWEIFS-YGRQPYPKMTVNEVKECV----EKGYRMDPPDECPADVYSIMTSCWQTEPKKRP 424
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-070705-183]) HSP 1 Score: 100.523 bits (249), Expect = 1.083e-21 Identity = 71/254 (27.95%), Postives = 123/254 (48.43%), Query Frame = 2
Query: 2084 LQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLM-KTDVSKYLK---RNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCK--SMALSNHSFVGTPVH-IAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
L + + E IG+G G V+ GQ +A K + + EE H L+PL+ V + + + I LM K ++ +L+ R VS+ + L+ AL V E +++L ++++HRDL NIL+ ++ ++D+G + SMA+ N PV APE ++ + + D++SYG+LLW + GR P + + + + E R + DE +++ +M +CW EP RP
Sbjct: 190 LSKLTLGEIIGEGEFGAVFAGEYTGQRVAVKIIKCDVTA-QAFLEETSVMTNLHHKNLVPLLGVILHNG-------LHIVTELMTKGNLVNFLRSRGRFAVSVIQLLRFALDVCEGMEHLESKKLLHRDLAGRNILVSEDGVAKISDFGLARVGSMAVDNSKL---PVKWTAPEALKNKKFSTQSDVWSYGVLLWEIFS-YGRQPYPKMTVNEVKECV----EKGYRMDPPDECPADVYSIMTSCWQTEPKKRP 427
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205]) HSP 1 Score: 182.956 bits (463), Expect = 6.855e-47 Identity = 144/533 (27.02%), Postives = 261/533 (48.97%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNY----KFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLK-RNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
R+ E EL+E + + + +L ++E L E ++ ++++ + I++P+NG + + ++ C + +I+S L Q + N + V+ L + + +E + S K + E+ + + L++IL + Y FNS G V + ++I+ I+ S + EWK + A++ ++ S LA+ +C ++ H AF +L+ ++ + ++ ++ + AP A L + + ++ + + ++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D + I++ + Y+ + +S++ RL+IAL V E +++LH Q ++HRD+KL N+LLD + + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F + S LW + RPERL +E W+LM+ACW+ +PS RP
Sbjct: 327 RQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKD-IAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDY-LRESFVGTLERCLRSLEKSQ---QESSSHVTSNH---LKQILNAAYHVEVTFNS--------GSTVTRMVWEQIVQIIQRI---------TWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-SGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASK--DHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 830
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205]) HSP 1 Score: 182.956 bits (463), Expect = 8.929e-47 Identity = 144/533 (27.02%), Postives = 261/533 (48.97%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNY----KFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLK-RNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
R+ E EL+E + + + +L ++E L E ++ ++++ + I++P+NG + + ++ C + +I+S L Q + N + V+ L + + +E + S K + E+ + + L++IL + Y FNS G V + ++I+ I+ S + EWK + A++ ++ S LA+ +C ++ H AF +L+ ++ + ++ ++ + AP A L + + ++ + + ++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D + I++ + Y+ + +S++ RL+IAL V E +++LH Q ++HRD+KL N+LLD + + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F + S LW + RPERL +E W+LM+ACW+ +PS RP
Sbjct: 390 RQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKD-IAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDY-LRESFVGTLERCLRSLEKSQ---QESSSHVTSNH---LKQILNAAYHVEVTFNS--------GSTVTRMVWEQIVQIIQRI---------TWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-SGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASK--DHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 893
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205]) HSP 1 Score: 182.185 bits (461), Expect = 9.905e-47 Identity = 144/533 (27.02%), Postives = 261/533 (48.97%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNY----KFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLK-RNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
R+ E EL+E + + + +L ++E L E ++ ++++ + I++P+NG + + ++ C + +I+S L Q + N + V+ L + + +E + S K + E+ + + L++IL + Y FNS G V + ++I+ I+ S + EWK + A++ ++ S LA+ +C ++ H AF +L+ ++ + ++ ++ + AP A L + + ++ + + ++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D + I++ + Y+ + +S++ RL+IAL V E +++LH Q ++HRD+KL N+LLD + + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F + S LW + RPERL +E W+LM+ACW+ +PS RP
Sbjct: 306 RQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKD-IAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDY-LRESFVGTLERCLRSLEKSQ---QESSSHVTSNH---LKQILNAAYHVEVTFNS--------GSTVTRMVWEQIVQIIQRI---------TWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-SGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASK--DHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 809
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205]) HSP 1 Score: 182.57 bits (462), Expect = 1.044e-46 Identity = 144/533 (27.02%), Postives = 261/533 (48.97%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNY----KFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLK-RNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
R+ E EL+E + + + +L ++E L E ++ ++++ + I++P+NG + + ++ C + +I+S L Q + N + V+ L + + +E + S K + E+ + + L++IL + Y FNS G V + ++I+ I+ S + EWK + A++ ++ S LA+ +C ++ H AF +L+ ++ + ++ ++ + AP A L + + ++ + + ++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D + I++ + Y+ + +S++ RL+IAL V E +++LH Q ++HRD+KL N+LLD + + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F + S LW + RPERL +E W+LM+ACW+ +PS RP
Sbjct: 367 RQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKD-IAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDY-LRESFVGTLERCLRSLEKSQ---QESSSHVTSNH---LKQILNAAYHVEVTFNS--------GSTVTRMVWEQIVQIIQRI---------TWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-SGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASK--DHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 870
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:493205]) HSP 1 Score: 182.57 bits (462), Expect = 1.246e-46 Identity = 144/533 (27.02%), Postives = 261/533 (48.97%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNY----KFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLK-RNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
R+ E EL+E + + + +L ++E L E ++ ++++ + I++P+NG + + ++ C + +I+S L Q + N + V+ L + + +E + S K + E+ + + L++IL + Y FNS G V + ++I+ I+ S + EWK + A++ ++ S LA+ +C ++ H AF +L+ ++ + ++ ++ + AP A L + + ++ + + ++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D + I++ + Y+ + +S++ RL+IAL V E +++LH Q ++HRD+KL N+LLD + + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F + S LW + RPERL +E W+LM+ACW+ +PS RP
Sbjct: 374 RQKENELYESLMRISDRKQEELKDMIVETLNSMREQLLEDAANMQFKD-IAIPQNGEPVSVQEVKCCIFQIKELIISRLNQAVVNKLISSVDY-LRESFVGTLERCLRSLEKSQ---QESSSHVTSNH---LKQILNAAYHVEVTFNS--------GSTVTRMVWEQIVQIIQRI---------TWVSPPTITPEWKRRVAQDAIESLSASKLAKSICSQFCKRLKSSHEAFAASLKQLEVGHSGRLEKTNDLWLRVRKDHAPRLARLSLESRSLQDVLLHGKPRIGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYSYGGGSSIAVLLITERLHRDLYVGLKTGLSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-SGKYDNSVDVYAFGILFWYICSGSVKLPEAFEKCASK--DHLWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRP 877
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Dstyk (dual serine/threonine and tyrosine protein kinase [Source:MGI Symbol;Acc:MGI:1925064]) HSP 1 Score: 200.675 bits (509), Expect = 1.611e-52 Identity = 155/536 (28.92%), Postives = 261/536 (48.69%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDE-IGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTE-----GHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
RK E EL+E + + + + ++ ++E L E +++ ++E+ + I VPENG I R I+ C Q +I+S L Q + N + V+ L + + +E + S K + + VH + SNY L A + E G +V L ++I K ++ + ++ EWK + A+E + S LA+ +C + H AF +L ++ +E++ ++ + AP A L + + ++ + + + +++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D +++ + + D+ LK ++++ RL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F R S LW + RPERL +E W+LM+ACWD +P RP
Sbjct: 393 RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVI-VPENGETIGTREIKSCIRQIQELIISRLNQAVANKLISSVDY-LRESFVGTLERCLQSLEKSQDVSVH-----------------ITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQI----KQIIQRITWVNPPTITL-----EWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAG-LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASK--DHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRP 895
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Dstyk (dual serine/threonine and tyrosine protein kinase [Source:MGI Symbol;Acc:MGI:1925064]) HSP 1 Score: 154.066 bits (388), Expect = 1.119e-37 Identity = 141/535 (26.36%), Postives = 239/535 (44.67%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDE-IGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTE-----GHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
RK E EL+E + + + + ++ ++E L E +++ ++E+ + I VPENG I R I+ C Q +I+S L Q + N + V+ L + + +E + S K + + VH + SNY L A + E G +V L ++I K ++ + ++ EWK + A+E + S LA+ +C + H AF +L ++ +E++ ++ + AP A L + + ++ + + + +++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D +++ + + D+ LK ++++ RL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ TG RPERL +E W+LM+ACWD +P RP
Sbjct: 393 RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVI-VPENGETIGTREIKSCIRQIQELIISRLNQAVANKLISSVDY-LRESFVGTLERCLQSLEKSQDVSVH-----------------ITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQI----KQIIQRITWVNPPTITL-----EWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAG-LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF------------------------TG-----------------------TRPERLPVFDEECWQLMEACWDGDPLKRP 850
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek7 (NIMA (never in mitosis gene a)-related expressed kinase 7 [Source:MGI Symbol;Acc:MGI:1890645]) HSP 1 Score: 105.916 bits (263), Expect = 2.204e-24 Identity = 84/271 (31.00%), Postives = 131/271 (48.34%), Query Frame = 2
Query: 2072 GRYMLQGIVVNEKIGQGAQGEVYRCSC--NGQEMAKKTVN----LPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVS---KYLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESV 2839
G L + +KIG+G EVYR SC +G +A K V + D +E+ HP ++ A I D+ +++I L D+S K+ K+ K I ER K +Q+ AL ++H +++MHRD+K AN+ + V L D G F S + HS VGTP +++PE + + Y+FK DI+S G LL+ +A F + N+ + + + P D S+EL +L+ C + +P RPDI V
Sbjct: 27 GYNTLANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDN------ELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYV 288
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek7 (NIMA (never in mitosis gene a)-related expressed kinase 7 [Source:MGI Symbol;Acc:MGI:1890645]) HSP 1 Score: 105.916 bits (263), Expect = 2.204e-24 Identity = 84/271 (31.00%), Postives = 131/271 (48.34%), Query Frame = 2
Query: 2072 GRYMLQGIVVNEKIGQGAQGEVYRCSC--NGQEMAKKTVN----LPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVS---KYLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESV 2839
G L + +KIG+G EVYR SC +G +A K V + D +E+ HP ++ A I D+ +++I L D+S K+ K+ K I ER K +Q+ AL ++H +++MHRD+K AN+ + V L D G F S + HS VGTP +++PE + + Y+FK DI+S G LL+ +A F + N+ + + + P D S+EL +L+ C + +P RPDI V
Sbjct: 27 GYNTLANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDN------ELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYV 288
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek6 (NIMA (never in mitosis gene a)-related expressed kinase 6 [Source:MGI Symbol;Acc:MGI:1891638]) HSP 1 Score: 98.5969 bits (244), Expect = 7.222e-22 Identity = 80/270 (29.63%), Postives = 131/270 (48.52%), Query Frame = 2
Query: 2075 RYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQL---------NDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVS---KYLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDI 2830
R L + +KIG+G EVY+ +C + +KTV L Q+ D +E+ HP ++ + I D+ +++I L D+S KY K+ K I ER K +Q+ A++++H +++MHRD+K AN+ + V L D G F S + HS VGTP +++PE + + Y+FK DI+S G LL+ +A F + N+ + + + P + S++L EL+ C +P RPDI
Sbjct: 39 RCSLADFQIEKKIGRGQFSEVYKATC---LLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDN------ELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCIYPDPDHRPDI 296
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6XUX2|DUSTY_RAT (Dual serine/threonine and tyrosine protein kinase OS=Rattus norvegicus OX=10116 GN=Dstyk PE=2 SV=1) HSP 1 Score: 203.756 bits (517), Expect = 9.871e-53 Identity = 156/536 (29.10%), Postives = 262/536 (48.88%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDE-IGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTE-----GHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
RK E EL+E + + + + ++ ++E L E +++ ++E+ + I VPENG + R I+ C Q +I+S L Q + N + V+ L + + +E + S K + + VH + SNY L A + E G +V L ++I K ++ + ++ EWK + A+E + S LA+ +C + H AF +L ++ +E++ ++ + AP A L + + ++ + + + +++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D +++ + + D+ LK +S++ RL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F R S LW + RPERL +E W+LM+ACWD +PS RP
Sbjct: 393 RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVI-VPENGETVGTREIKSCIRQIQELIISRLNQAVANKLISSVDY-LRESFVGTLERCLQSLEKSQDVSVH-----------------ITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQI----KQIIQRITWVNPPTITL-----EWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAG-LSLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASK--DHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPSKRP 895
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q4TVR5|DUSTY_BOVIN (Dual serine/threonine and tyrosine protein kinase OS=Bos taurus OX=9913 GN=DSTYK PE=2 SV=1) HSP 1 Score: 203.756 bits (517), Expect = 1.059e-52 Identity = 157/536 (29.29%), Postives = 262/536 (48.88%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDE-IGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTE-----GHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
RK E EL+E + + + + ++ ++E L E +++ ++E+ + I VPENG + R I+ C Q +I+S L Q + N + V+ L + + +E + S K + + VH + SNY L A + E G +V L ++I I+ S + EWK + A+E ++ S LA+ +C + H AF +L ++ +E++ ++ + AP A L + + ++ + + + +++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D + I++ + + D+ LK ++++ RL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F R S LW + RPERL +E W+LM+ACWD +PS RP
Sbjct: 394 RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVI-VPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDY-LRESFVGTLERCLQSLEKSQDVSVH-----------------ITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRI---------TWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYSYGGGSSIAVLLIMERLHRDLYTGLKAG-LALETRLQIALDVVEGIRFLHSQGLVHRDVKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASK--DHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPSQRP 896
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6XUX1|DUSTY_MOUSE (Dual serine/threonine and tyrosine protein kinase OS=Mus musculus OX=10090 GN=Dstyk PE=1 SV=1) HSP 1 Score: 200.675 bits (509), Expect = 1.127e-51 Identity = 155/536 (28.92%), Postives = 261/536 (48.69%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDE-IGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTE-----GHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
RK E EL+E + + + + ++ ++E L E +++ ++E+ + I VPENG I R I+ C Q +I+S L Q + N + V+ L + + +E + S K + + VH + SNY L A + E G +V L ++I K ++ + ++ EWK + A+E + S LA+ +C + H AF +L ++ +E++ ++ + AP A L + + ++ + + + +++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D +++ + + D+ LK ++++ RL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F R S LW + RPERL +E W+LM+ACWD +P RP
Sbjct: 393 RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVI-VPENGETIGTREIKSCIRQIQELIISRLNQAVANKLISSVDY-LRESFVGTLERCLQSLEKSQDVSVH-----------------ITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQI----KQIIQRITWVNPPTITL-----EWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAG-LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASK--DHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRP 895
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q20CR4|DUSTY_MACMU (Dual serine/threonine and tyrosine protein kinase OS=Macaca mulatta OX=9544 GN=DSTYK PE=2 SV=1) HSP 1 Score: 200.29 bits (508), Expect = 1.135e-51 Identity = 156/536 (29.10%), Postives = 260/536 (48.51%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDE-IGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTE-----GHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYY-SYLFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
RK E EL+E + + + + ++ ++E L E +++ ++E+ + I VPENG + R I+ C Q +I+S L Q + N + V+ L + + +E + S K + + VH + SNY L A + E G +V L ++I I+ S + EWK + A+E ++ S LA+ +C + H AF +L ++ +E++ ++ + AP A L + + ++ + + + +++G+G G VY C G A K+V P ND+A E +Y L +H RL+ L S+ D I++ + + D+ LK ++++ RL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G+ + P F R S LW + RPERL +E W+LM+ACWD +P RP
Sbjct: 373 RKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVI-VPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDY-LRESFVGTLERCLQSLEKSQDVSVH-----------------ITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRI---------TWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHG-SVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAG-LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASK--DHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRP 875
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6XUX0|DUSTY_CHICK (Dual serine/threonine and tyrosine protein kinase OS=Gallus gallus OX=9031 GN=DSTYK PE=2 SV=1) HSP 1 Score: 200.29 bits (508), Expect = 1.412e-51 Identity = 156/536 (29.10%), Postives = 261/536 (48.69%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQC----QGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKD-EIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTE-----GHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEM--AKKTVNLP-MNQLNDIAEEVYYSYLFQ-HPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPR-FARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
R+ E EL+E + + + + ++ +IE L + E ++ ++E+ + I +PENG + + I+ C Q +I+S L Q + N + V+ L + + +E + S + E+ VH A+ L K+ + + SNY L A + E G V L ++I I+ S + +WK + A++ ++ S LA+ +C + H AF +L ++ +E++ ++ + AP A L + + ++ + + ++G+G G VY C G A K+V P ND+A E +Y Q H RL+ L S+ D I++ + + D+ LK + ++ RL+IAL V E ++YLH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WY+ G + P F R S LW + +RPERL +E W+LM+ACWD + S RP
Sbjct: 382 RRKENELYESLMNIANRKQEEMKDMIIETLSNMKEELLEDAANMEFKDII-IPENGEPVSSKDIKCCIKQIQELIISRLNQAVANKLISSVDY-LRESFVGTLERCLKSLEESWEVSVHPARSLEKSK---DVSVHITSNYLKQILNAAYHVEVTFHSGSTVTRMLWEQIKQIIQRI---------TWVSPPAITSDWKRKVAQDAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEDGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHGKPKLGRELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLQSHERLVDLHG-SVIDYGYGGGSSIAVLLIMERLHRDLYTGLKAG-LELETRLQIALDVVEGIRYLHSQGLVHRDIKLKNVLLDKKNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYICSGHVKLPEAFERCASK--DHLWNNVRRGVRPERLPVFDEECWQLMEACWDGDSSQRP 898
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267FM29 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig021056g2 PE=4 SV=1) HSP 1 Score: 400.208 bits (1027), Expect = 2.895e-120 Identity = 271/882 (30.73%), Postives = 462/882 (52.38%), Query Frame = 2
Query: 332 KQDVNQ--------KVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENG-KVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIK-LAESKMELAFKKLQYNNFI-PTSFKHWSECPYFHGASLYCYMDYY--------KNKRTEEILFHFD------LFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNS-ISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVD--VKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEK--IGQGAQGEVYRCSCNGQE--MAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQ--ISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILL-DDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTG-RHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLILEN 2869
+Q VNQ D P I IVGQ K+GKS+F+N LL V Q+ CTAR+TRLTYS + YV + + G ++ + + L KPTI + ++L DEDR I+ V AGIK +FL +GIDIIDSPGL+EN++L +L+ I S LPI+IYVID + + DL +K V ++ Y ++K+D TE E + P + + E K E F KLQ +I P K +C F S + + KNK E L + F + + + F F+N I + + Q ++LT + +A + + ++ I+ +E+E+ ++ K ++ ++++L+++ + I++ + L+Y S IS + I+K+ +++ +I + + +K Q++ D +K ++ +E K + +TP L++ L Y +S + ++ + I+ IK F ++ + S+ ++ +WK QA++ L L E + SL + FE +H FL + + + V + ++E+ R+++ P A L MLT+DV +Y +G ++ + +G GAQGEV+R E +A K + L+DIA EVY+S + +H L+ ++ V + S D K+ + I+ LM D ++R+++ +++RLKI L++A+ALQ+LH +++HRD+KLAN+L+ +D V L+D+G KS N + VGTP+++APE+VR Y D++S G+ LWYL EGTG RHP + + ++ +L A + RP RL +SD+LW+LM++CW P RP ++ + + I+++
Sbjct: 65 RQKVNQLYRGNQTGSSDSSKPCIIIVGQTKSGKSSFINELLGGTFVAQSQSPCTARVTRLTYSDRIYVLVRSKTGEQIGDVQYLEKPTIEEDLVKLKDEDRENDELISSTVEAGIKCEFLRHGIDIIDSPGLNENSSLDSLTLGAIDSFLPIIIYVIDSNSGITVAVQKDLTTIKKTVLGAEVFYLVTKMDVSKDTEQEANRPAQEIEEEKAERVFSKLQRLGYISPNETKE--KCNKFLCVSCWEVRRFRRKKELMIKKNKLDPEALKEMENSKWVRRFEEVKTRILKFAQDQFRNLIVSSGGGLRRIQSEILTLFMDKATNIKESNLRKKKALYQIKSLEQEIHQQSKSIVEKNRDELLRQAGLFFAERKPLILDEVRALKYSESVISADMSQKDIEKKCVDEIHALINDRIIASFCDFLKDGALRLCLQEFDD---------LKQKVAEYE-KDVEQTPAYQVLKKTLLEGYSLSS---------KDFLLGPLNVIIFRIKHFVRQMVRNPGLVLSISTPIQDQKWKEYQAEKYLGTISKENLVECLITSLKEWFEKQHREFLDNIASSEQLVESCMKLTEKERSEIKTLYPRVARLHMLTMDVISKYKYRGFRIDTEGNLGSGAQGEVFRVLNESGEPALAAKRIVSDEPSLDDIATEVYHSSVLEHDNLVHVVGVRLHKSKP-DEKRWTVEIYMELMCCDAWNLMQRHRLPVRQRLKIGLELAKALQFLHSSELIHRDVKLANVLVSEDLRQVKLSDFGLVKSTGFVNRTLVGTPIYLAPELVRGESYHTSADVFSLGIALWYLFEGTGKRHPEYVEIMPSVGAILLAGA-LDCRPTRLPNMSDQLWDLMESCWSGTPDSRPTAKAAVESLQKIVDS 923
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267FLZ4 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig023032g1 PE=4 SV=1) HSP 1 Score: 396.741 bits (1018), Expect = 4.394e-119 Identity = 280/891 (31.43%), Postives = 463/891 (51.96%), Query Frame = 2
Query: 335 QDVNQKV------------DIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENG-KVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIK-LAESKMELAFKKLQYNNFI-PTSFKHWSECPYFHGASLYCYMDYY--------KNKRTEEILFHFD------LFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVL--SDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNS-ISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEA-KCLGKT---PYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQI--KESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEK--IGQGAQGEVYRCSCNGQE--MAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQ--ISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILL-DDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTG-RHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLILEN 2869
+DV QKV D P I IVGQ K+GKS+F+N LL V Q+ CTAR+TRLTYS + YV + + G ++ + + L KPTI + ++L DEDR I+ V AGIK +FL +GIDIIDSPGL+EN++L +L+ I S LPI+IYVID + + DL +K V ++ Y ++K+D TE E + P + + E K E F KLQ +I P + C F S + + KNK E L + F + + + F F+N I + D +++ Q ++LT + RA + S+ KE L + I+ +E+E +++ K ++ ++++L+++ + I++ + L+Y S IS + I+K+ +++ +I + +I F + + + + ++ ++ A + L KT Y +SLE + S F I+ IK F K+ + S ++ +WK QA++ L+ + + L E + L + E +H FL + + + V + ++EE R+++ P A L MLT+DV +Y +G ++ + +G GAQGEV+R E +A K + L+DIA EVY+S + +H L+ ++ V + S D K+ + I+ LM D ++R+++ +++RLKI L++A+ALQ+LH +++HRDLKLAN+L+ +D V L+D+G KS N + VGTP+++APE+VR Y D++S G+ LWYL EGTG RHP + + ++ +L AS + RP RL +SD+LW+LM++CW P RP E + + I+++
Sbjct: 62 EDVRQKVNQLYRGNQTGSSDSSKPCIIIVGQTKSGKSSFINELLGGTFVAQSQSPCTARVTRLTYSDRIYVLVRSKTGEQIGDVQYLEKPTIEEDLVKLKDEDRENDELISSTVEAGIKCEFLRHGIDIIDSPGLNENSSLDSLTLGAIDSFLPIIIYVIDSNSGITIAVQKDLTTIKKTVLGAEVFYLVTKMDVSKDTEQEANQPAQEIEEEKAERVFSKLQRLGYISPNETR--DTCNKFLCVSCWKVRGFRRKKELMIKKNKLDPEALKEMENSKWVRRFEEVKTRILKFAQDQFRNLIVRSGDELMHIQSEILTLFMDRATNIKESNLRKEAL---YQIKSLEQETYQQSKSIVEKNRDELLRQAGLFFAERKPLILDEVRALKYSESVISADMSQKDIEKKCVDEIHALIN-------DRIIASFFDFFKNHGLKGFDLKNLMAELEKDVNPTPAYQVLKKTMLMSYSVSLEELKLSCLGF---------------------IIFKIKFFVIKIVTKPGLVFSTSTPIQDPKWKKYQAEKYLEAINKNILVERLITWLKEWLEKQHREFLDNIASSEQLVESGMKLTEEERSEIKSLFPRVARLHMLTMDVISKYKYRGFRIDTEGNLGSGAQGEVFRVLNESGEPALAAKRIVSDEPSLDDIATEVYHSSVLEHDNLVHVVGVRLHKSKP-DEKRWTVEIYMELMCCDAWNLMQRHRLPVRQRLKIGLELAKALQFLHSSELIHRDLKLANVLVSEDLRQVKLSDFGLVKSTGFVNRTLVGTPIYLAPELVRGESYHTSADVFSLGIALWYLFEGTGKRHPEYVEIMPSVGAILLASA-LDCRPTRLPNMSDQLWDLMESCWSGTPDSRPTAEEAVESLQKIVDS 917
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267FEQ6 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig021099g2 PE=4 SV=1) HSP 1 Score: 387.111 bits (993), Expect = 2.286e-115 Identity = 271/888 (30.52%), Postives = 466/888 (52.48%), Query Frame = 2
Query: 332 KQDVNQ--------KVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENG-KVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIK-LAESKMELAFKKLQYNNFI-PTSFKHWSECPYFHGASLYCYMDYY--------KNKRTEEILFHFD------LFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNS-ISVPENGMVIDKRLIEQCQGV----IMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVD--VKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEK--IGQGAQGEVYRCSCNGQE--MAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSK-QISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILL-DDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTG-RHPRFARVQSNIAQVLWASTEHNMRPERLDEIS---DELWELMQACWDNEPSVRPDIESVLCKITLILEN 2869
+Q VNQ D P I IVGQ K+GKS+F+N LL V Q+ CTAR+TRLTYS + YV + + G ++ + + L KPTI + ++L D+DR + I+ V AGIK +FL +GIDIIDSPGL+EN++L +L+ I S LPI+IYVID T + DL +K V ++ Y ++K+D TE E + + + E K E F KLQ I P K +C F S + + KNK + L + F + + + F F+N I + + Q ++LT + +A + + ++ I+ +E+E+ ++ K ++ ++++L+++ + I++ + L+Y S I+ + I+K+ +++ + + I++S C L++ + ++E R+K + +E K + +TP L++ L Y +LS E +K I+ IK F +F ++ S+ ++ WK QA++ ++ L E + +LI+ FE H+ FL + + + V + ++E+ R+++ P A L MLT+DV +Y +G ++ + +G GAQGEV+R E +A K + L+DIA EVY+S + +H L+ ++ V + S + + + I+ LM D ++R+++ +++RLKI L++A+ALQ+LH +++HRD+KLAN+L+ +D V L+D+G KS N + VGTP+++APE+VR Y D++S G+ LWYL EGTG RHP + + ++ +L A + RP RL +S D+LW+LM++CW P RP ++ + + I+++
Sbjct: 65 RQKVNQLYRGNQTGSSDSSKPCIIIVGQTKSGKSSFINELLGGTFVAQSQSPCTARVTRLTYSDRIYVLVRSKTGEQIGDVQYLEKPTIEEDLVKLKDKDRENKELISSTVEAGIKCEFLRHGIDIIDSPGLNENSSLDSLTLGAIDSFLPIIIYVIDSNTGITVAVQNDLTRIKQTVLGAEVFYLVTKMDVSKDTEQEANQTAQEIEEEKAERVFSKLQSLKCISPNETKE--KCSKFLCVSCWKVRGFRRKKELMIKKNKLDPKALKEMENSKWVRRFEEVKTRILKFAQDQFRNLIVSSGGGLRRIQSEILTLFMDKATNIKESNLRKKKALYQIKSLEQEIHKQSKSIVEKNRDELLRQAGLFFAERKPLILDEVRALKYSESVITADMSRKDIEKKCVDEIRALINDRIIASFCDFLKDGALRTCQNEF-------------DRLKQVVAEYE-KNVKQTPTYQVLKKTLLVGY------SLSPEEVRPGCLKY---IIIRIKTFVKHIFKNPRLVFSISKPIQDPNWKEYQAEKYVEAMSKENLVECLITALIEWFEMCHSEFLDNIASSEQLVESCMKLTEKERSEIKTLYPRVARLHMLTMDVISKYKYRGFRIDTEGNLGSGAQGEVFRVLNESGEPALAAKRIVSDEPSLDDIATEVYHSSVLKHENLVHVVGVRLHKSKSDEKRWTVEIYMELMCCDAWNLMQRHRLPVRQRLKIGLELAKALQFLHSSELIHRDVKLANVLVSEDLRQVKLSDFGLMKSTGFVNRTLVGTPIYLAPELVRGESYHTSADVFSLGIALWYLFEGTGKRHPEYVEIMPSVGAILLAGA-LDCRPTRLPNMSDQPDQLWDLMESCWSGTPDSRPTAKAAVESLQKIVDS 926
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1I8G8Z8 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 376.711 bits (966), Expect = 5.672e-112 Identity = 268/880 (30.45%), Postives = 446/880 (50.68%), Query Frame = 2
Query: 332 KQDVNQ--------KVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENG-KVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIK-LAESKMELAFKKLQYNNFI-PTSFKHWSECPYFHGASLYCYMDYY--------KNKRTEEILFHFD------LFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNS-ISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEK--IGQGAQGEVYRCSCNGQE--MAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQ--ISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILL-DDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTG-RHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLILEN 2869
+Q VNQ D P I IVGQ K+GKS+F+N LL V Q+ CTAR+TRLTYS + YV + + G ++ + + L KPTI + ++L DEDR I+ V AGIK +FL +GIDIIDSPGL+EN++L +L+ I S LPI+IYVID + + DL +K V ++ Y ++K+D TE E + P + + E K E F KLQ +I P K +C F S + + KNK E L + F + + + F F+N I + + Q ++LT + +A + + ++ I+ +E+E+ ++ K ++ ++++L+++ + I++ + L+Y S IS + I+K+ +++ +I + + +K Q++ D +K ++ +E K + +TP L++ L Y +S K F L GT +KE L C + SL + FE +H FL + + + V + ++E+ R+++ P A L MLT+DV +Y +G ++ + +G GAQGEV+R E +A K + L+DIA EVY+S + +H L+ ++ V + S D K+ + I+ LM D ++R+++ +++RLKI L++A+ALQ+LH +++HRD+KLAN+L+ +D V L+D+G KS N + VGTP+++APE+VR Y D++S G+ LWYL EGTG RHP + + ++ +L A + RP RL +SD+LW+LM++CW P RP ++ + + I+++
Sbjct: 65 RQKVNQLYRGNQTGSSDSSKPCIIIVGQTKSGKSSFINELLGGTFVAQSQSPCTARVTRLTYSDRIYVLVRSKTGEQIGDVQYLEKPTIEEDLVKLKDEDRENDELISSTVEAGIKCEFLRHGIDIIDSPGLNENSSLDSLTLGAIDSFLPIIIYVIDSNSGITVAVQKDLTTIKKTVLGAEVFYLVTKMDVSKDTEQEANRPAQEIEEEKAERVFSKLQRLGYISPNETKE--KCNKFLCVSCWEVRRFRRKKELMIKKNKLDPEALKEMENSKWVRRFEEVKTRILKFAQDQFRNLIVSSGGGLRRIQSEILTLFMDKATNIKESNLRKKKALYQIKSLEQEIHQQSKSIVEKNRDELLRQAGLFFAERKPLILDEVRALKYSESVISADMSQKDIEKKCVDEIHALINDRIIASFCDFLKDGALRLCLQEFDD---------LKQKVAEYE-KDVEQTPAYQVLKKTLLEGYSLSS------------------------KDF---LLGT-----------------ISKENLVEC--------LITSLKEWFEKQHREFLDNIASSEQLVESCMKLTEKERSEIKTLYPRVARLHMLTMDVISKYKYRGFRIDTEGNLGSGAQGEVFRVLNESGEPALAAKRIVSDEPSLDDIATEVYHSSVLEHDNLVHVVGVRLHKSKP-DEKRWTVEIYMELMCCDAWNLMQRHRLPVRQRLKIGLELAKALQFLHSSELIHRDVKLANVLVSEDLRQVKLSDFGLVKSTGFVNRTLVGTPIYLAPELVRGESYHTSADVFSLGIALWYLFEGTGKRHPEYVEIMPSVGAILLAGA-LDCRPTRLPNMSDQLWDLMESCWSGTPDSRPTAKAAVESLQKIVDS 878
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1I8HXC8 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 373.244 bits (957), Expect = 9.624e-111 Identity = 265/876 (30.25%), Postives = 442/876 (50.46%), Query Frame = 2
Query: 332 KQDVNQ--------KVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENG-KVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIK-LAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCY-----MDYYKNKRTEEILFHFD------LFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNS-ISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEK--IGQGAQGEVYRCSCNGQE--MAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQ--ISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILL-DDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTG-RHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLILEN 2869
+Q VNQ D P I IVGQ K+GKS+F+N LL V Q+ CTAR+TRLTYS + YV + + G ++ + + L KPTI + ++L DEDR I+ V AGIK +FL +GIDIIDSPGL+EN++L +L+ I S LPI+IYVID + + DL +K V ++ Y ++K+D TE E + P + + E K E F KLQ +I + + F + + KNK E L + F + + + F F+N I + + Q ++LT + +A + + ++ I+ +E+E+ ++ K ++ ++++L+++ + I++ + L+Y S IS + I+K+ +++ +I + + +K Q++ D +K ++ +E K + +TP L++ L Y +S K F L GT +KE L C + SL + FE +H FL + + + V + ++E+ R+++ P A L MLT+DV +Y +G ++ + +G GAQGEV+R E +A K + L+DIA EVY+S + +H L+ ++ V + S D K+ + I+ LM D ++R+++ +++RLKI L++A+ALQ+LH +++HRD+KLAN+L+ +D V L+D+G KS N + VGTP+++APE+VR Y D++S G+ LWYL EGTG RHP + + ++ +L A + RP RL +SD+LW+LM++CW P RP E + + I+++
Sbjct: 65 RQKVNQLYRGNQTGSSDSSKPCIIIVGQTKSGKSSFINELLGGTFVAQSQSPCTARVTRLTYSDRIYVLVRSKTGEQIGDVQYLEKPTIEEDLVKLKDEDRENDELISSTVEAGIKCEFLRHGIDIIDSPGLNENSSLDSLTLGAIDSFLPIIIYVIDSNSGITVAVQKDLTTIKKTVLGAEVFYLVTKMDVSKDTEQEANRPAQEIEEEKAERVFSKLQRLGYISPNETRDNATSSFASRVGKRFRRKKELMIKKNKLDPEALKEMENSKWVRRFEEVKTRILKFAQDQFRNLIVSSGGGLRRIQSEILTLFMDKATNIKESNLRKKKALYQIKSLEQEIHQQSKSIVEKNRDELLRQAGLFFAERKPLILDEVRALKYSESVISADMSQKDIEKKCVDEIHALINDRIIASFCDFLKDGALRLCLQEFDD---------LKQKVAEYE-KDVEQTPAYQVLKKTLLEGYSLSS------------------------KDF---LLGT-----------------ISKENLVEC--------LITSLKEWFEKQHREFLDNIASSEQLVESCMKLTEKERSEIKTLYPRVARLHMLTMDVISKYKYRGFRIDTEGNLGSGAQGEVFRVLNESGEPALAAKRIVSDEPSLDDIATEVYHSSVLEHDNLVHVVGVRLHKSKP-DEKRWTVEIYMELMCCDAWNLMQRHRLPVRQRLKIGLELAKALQFLHSSELIHRDVKLANVLVSEDLRQVKLSDFGLVKSTGFVNRTLVGTPIYLAPELVRGESYHTSADVFSLGIALWYLFEGTGKRHPEYVEIMPSVGAILLAGA-LDCRPTRLPNMSDQLWDLMESCWSGTPDSRPTAEKAVESLQKIVDS 876
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:402922]) HSP 1 Score: 151.369 bits (381), Expect = 4.863e-37 Identity = 140/544 (25.74%), Postives = 248/544 (45.59%), Query Frame = 2
Query: 1271 RKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRL---IEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNS---IKLFFSKLFGT-----DQIKESVD--------VKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQE--MAKKTVNLPMNQ-LNDIAEEVYYSY-LFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
R+ E ELF + + + + ++ + ++E L E ++ +LE+ + I P V K + I+Q Q +I+ L Q + N + + S Y R++ +G +LER L+S K + +++ HNV +++ILN+ +++ F +QIK+ + + EWK + A++ ++ + LA+ +C + H+AF +L + ++ +E++ ++ + AP A L + + ++ + + ++G+G G VY C G++ A K+V P ++ ND+A E +Y+ L +H RL+ L S+ D T I++ + + D+ LK +S+KERL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ TG RPERL +E W+LM+ACW+ +P RP
Sbjct: 375 REKESELFASLMAIANRKQEEMKEMIVETLSTMKEQLLEDAANLEFTDIIVTPNGEPVTTKEIKSCIQQIQELIVVRLNQAVAN---KLISSVDY--LRESF-----------VG--------------TLERCLSSLEK-----STTDSSVHNVTSNHLKQILNAAYHVEVTFHSGSSVTRLVWEQIKQIIQRLTWVNPPAITPEWKRKVAQDAIESLSAAKLAKSICSQFRTRLNSSHDAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLYGKPKLGRELGRGQYGVVYLCDKWGEQNPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVNLHG-SVIDHTYGGGSSIAVLLIMERLHRDLYTGLKAG-LSLKERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF------------------------TGS-----------------------RPERLPTFDEECWQLMEACWNGDPLQRP 834
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:NCBI gene;Acc:103034670]) HSP 1 Score: 99.7525 bits (247), Expect = 1.106e-21 Identity = 74/256 (28.91%), Postives = 129/256 (50.39%), Query Frame = 2
Query: 2084 LQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLK---RNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCK--SMALSNHSFVGTPVH-IAPEIVRKAIYDFKVDIYSYGMLLW-YLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDI 2830
L G+ + E IG+G G VY G+++A K + + + E + L QH L+ L+ V + + + ++ ++ K ++ YL+ R+ +S + L AL+V E ++YL ++++HRDL NILL ++N ++D+G K S A N PV APE ++ + D++SYG+LLW + G +P+ + +Q QV E R E + E++ +M+ CW+ EP +RP
Sbjct: 165 LAGLTLGESIGEGEFGAVYEGEYMGRKVAVKNIKSDVTAQAFLGETSVMTKL-QHKNLVQLLGVILHNGLYIVTEFMA------KGNLVNYLRSRGRSVISTVQLLHYALEVCEGMEYLECKKLVHRDLAARNILLSEDNVAKVSDFGLAKVDSQAFDNTKL---PVKWTAPEGLKNKKISTRSDVWSYGVLLWEIFSYGMQPYPKMS-LQEVKEQV-----EQGYRMEAPEACPPEVYTIMRDCWEKEPKMRPSF 404
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: matk (megakaryocyte-associated tyrosine kinase [Source:NCBI gene;Acc:103034670]) HSP 1 Score: 99.7525 bits (247), Expect = 1.421e-21 Identity = 75/256 (29.30%), Postives = 129/256 (50.39%), Query Frame = 2
Query: 2084 LQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLK---RNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCK--SMALSNHSFVGTPVH-IAPEIVRKAIYDFKVDIYSYGMLLW-YLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDI 2830
L G+ + E IG+G G VY G+++A K + + + E + L QH L+ L+ V + + + ++ F + K ++ YL+ R+ +S + L AL+V E ++YL ++++HRDL NILL ++N ++D+G K S A N PV APE ++ + D++SYG+LLW + G +P+ + +Q QV E R E + E++ +M+ CW+ EP +RP
Sbjct: 192 LAGLTLGESIGEGEFGAVYEGEYMGRKVAVKNIKSDVTAQAFLGETSVMTKL-QHKNLVQLLGVILHNGLYI----VTEF--MAKGNLVNYLRSRGRSVISTVQLLHYALEVCEGMEYLECKKLVHRDLAARNILLSEDNVAKVSDFGLAKVDSQAFDNTKL---PVKWTAPEGLKNKKISTRSDVWSYGVLLWEIFSYGMQPYPKMS-LQEVKEQV-----EQGYRMEAPEACPPEVYTIMRDCWEKEPKMRPSF 431
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: nek7 (NIMA related kinase 7 [Source:NCBI gene;Acc:103046491]) HSP 1 Score: 95.9005 bits (237), Expect = 3.230e-21 Identity = 78/263 (29.66%), Postives = 126/263 (47.91%), Query Frame = 2
Query: 2072 GRYMLQGIVVNEKIGQGAQGEVYRCS--CNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESV 2839
G L + +KIG+G EVYR N +A K + QLN Y++ + L I + + D+ +L S+ I K+ K+ + I E+ K +Q+ AL+++H +++MHRD+K AN+ + V L D G F S + HS VGTP +++PE + + Y+FK DI+S G LL+ +A F + N+ + + + P D S+EL +L+ C + +P RPDI V
Sbjct: 33 GYSTLSNFQIEKKIGRGQFSEVYRARYLINNTAVALKKIQ----QLNHPNVIKYHASFIEENELN--IVLELADAGDL-SRMI------------KHFKKQRRLIPEKTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRKLVDMCINPDPERRPDIAYV 273
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: nek6 (NIMA-related kinase 6 [Source:ZFIN;Acc:ZDB-GENE-040724-133]) HSP 1 Score: 94.3597 bits (233), Expect = 1.130e-20 Identity = 78/268 (29.10%), Postives = 128/268 (47.76%), Query Frame = 2
Query: 2084 LQGIVVNEKIGQGAQGEVYRCS--CNGQEMAKKTVN----LPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVS---KYLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVL 2842
L + +KIG+G EVYR + Q++A K V + D +E+ HP ++ + I D+ +++I L D+S KY K+ + I ER K +Q+ A++++H +++MHRD+K AN+ + V L D G F S HS VGTP +++PE + + Y+FK DI+S G LL+ +A F Q N+ + + + P + S++L L+ C + + RPDI VL
Sbjct: 28 LSNFRIEKKIGRGQFSEVYRATYLLENQQVALKKVQIFEMMDAKSRQDCIKEIDLLKQLNHPNVIKYLDSFIEDN------ELNIVLELADAGDLSHMIKYFKKKRRLIPERTIWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTVVHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALQSPFYSDQMNLLSLCQKIEQCDYPPLPPEHFSEKLRSLVSMCINPDADERPDIVFVL 286
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: STK36 (serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209]) HSP 1 Score: 95.5153 bits (236), Expect = 4.058e-20 Identity = 76/250 (30.40%), Postives = 130/250 (52.00%), Query Frame = 2
Query: 2099 VNEKIGQGAQGEVY--RCSCNGQEMAKK---TVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLK-IALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSN---HSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVR 2821
V E IG+G+ G+VY R GQ +A K V +L ++ E+ QHP + V + DS E D K++ + + ++ + L+ + +E+++ IA Q+ AL YLH +I+HRD+K NILL V L D+GF ++M+++ S GTP++++PE+V + YD D++S G +L+ L GT P F ++I Q++ + ++ + +S E +Q EP +R
Sbjct: 6 VLEMIGEGSFGKVYKGRKRYTGQVVALKFIPKVGRSDKELRNLRREIDIMRGLQHPNI-----VQMLDSFETD-KEVVVVTDYAEGELFQILEDDGNLPEEQVREIACQLVSALYYLHSHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSINTLVLTSIKGTPLYMSPELVEEKPYDHTADLWSMGCILYELFVGT---PPF--YTNSIFQLVSLIIKDPVKWPK--NMSSEFRNFLQGLLTKEPKLR 242
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006100.1 (pep scaffold:Pmarinus_7.0:GL478927:1672:12797:-1 gene:ENSPMAG00000005510.1 transcript:ENSPMAT00000006100.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 88.9669 bits (219), Expect = 1.466e-19 Identity = 65/256 (25.39%), Postives = 120/256 (46.88%), Query Frame = 2
Query: 2093 IVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELD--SKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLH---RQQIMHRDLKLANILLDDNNNVF-LADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVL 2842
I+V E +G+GA G V + G ++A K + + I E S + HP ++ L + + ++ S++ L + Y + ++ LQ A+ + YLH + ++HRDLK N+LL + + D+G + + G+ +APE+ + Y K D++S+G++LW + T R P F + +++WA + RP + + + LM CWD EP++RP +E ++
Sbjct: 26 IIVEEVVGRGAFGVVCKAKWRGMDVAIKQIESESERKAFIVELRQLSRV-NHPNIVRLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYY-----TAAHAMRWCLQCAQGVAYLHCMKPKALIHRDLKPPNLLLISGGTILKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVI--TRRKP-FDEIGGPAFRIMWA-VHNGTRPPLIKNLPKPIEGLMTRCWDKEPALRPSMEEIV 271
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008193.1 (pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-1 gene:ENSPMAG00000007385.1 transcript:ENSPMAT00000008193.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 85.8853 bits (211), Expect = 5.943e-18 Identity = 63/252 (25.00%), Postives = 116/252 (46.03%), Query Frame = 2
Query: 2111 IGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNK-VSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSM--ALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITL 2857
+G GAQG V+ G+ +A K V ++ + + +HP ++ V I + + + L+ + +S + + +A + YLH +I+HRDLK N+L+ ++ V ++D+G K M + SF GT +APE++R KVDI+S+G++LW L TG P + V S + ++W +++ + L+ CW+++P RP +L + +
Sbjct: 20 LGSGAQGAVFLGKFRGEHVAVKKVR------EQKETDIKHLHKLRHPNIITFKGVCTHAPC-----YCIIMEYCAQGQLYEVLRAGRRISPELLVGWTRGIARGMSYLHLHKIIHRDLKSPNVLITHDDEVKISDFGTSKEMREKSTRMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL--TGEIP-YRDVDS--SAIIWGVGSNSLHLPIPASCPEGFKILLTQCWNSKPRNRPSFRQILLHLEI 255
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: phkg1b (phosphorylase kinase, gamma 1b (muscle) [Source:ZFIN;Acc:ZDB-GENE-050522-52]) HSP 1 Score: 85.1149 bits (209), Expect = 1.112e-17 Identity = 69/264 (26.14%), Postives = 130/264 (49.24%), Query Frame = 2
Query: 2102 NEKIGQGAQGEVYRC--SCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIA-----VSITDSTELDSKQISIFAPLMKTDVSKYL-KRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSN--HSFVGTPVHIAPEIVRKAI------YDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLC 2845
E +G G V RC GQ+ A K +++ ++L++ E YS + +L ++ +++ D+ E + +F + + ++ YL ++ +S K+ I + E + +LH + I+HRDLK NILLDDN N+ L+D+GF + GTP +++PE+++ ++ Y +VD+++ G++++ L G+ P + R Q + +++ PE D SD + +L+ EP R E L
Sbjct: 28 KEVLGSGVSSVVRRCVHKRTGQDFAVKIIDITPDRLSEEELEDIYSSTVKEVDILKAVSGHPHIITLIDAYESSTFFFLVFDLMKRGELFDYLTEKVALSEKDTRSIMRSIFEVVHFLHAKNIVHRDLKPENILLDDNMNIRLSDFGFSMQLRPGERLRELCGTPGYLSPELLKCSMDESHPGYGKEVDLWACGVIMYTLLAGSP--PFWHRKQMTMLRLIMDGKYDFSTPEWEDR-SDTVKDLISRLLVVEPEKRFTAEQALA 288
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897]) HSP 1 Score: 85.1149 bits (209), Expect = 1.704e-17 Identity = 59/194 (30.41%), Postives = 102/194 (52.58%), Query Frame = 2
Query: 2111 IGQG--AQGEVYRCSCNGQEMAKKTVN---LPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYL-KRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNH--SFVGTPVHIAPEIVRKAIYDF-KVDIYSYGMLLWYLAEGT 2665
IG+G A+ ++ + + GQE+A K ++ L + L + EV + HP ++ L V E++ + +V YL ++ KE Q+ A+QY H++ I+HRDLK N+LLD + N+ +AD+GF L + +F G+P + APE+ + YD +VD++S G++L+ L G+
Sbjct: 74 IGKGNFAKVKLAKHTLTGQEVAVKIIDKTQLNTSSLQKLFREVRIMKVLNHPNIVKLFEV-----IEMEKTLYLVMEYSSGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGS 262
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 89.3521 bits (220), Expect = 3.094e-19 Identity = 61/208 (29.33%), Postives = 109/208 (52.40%), Query Frame = 2
Query: 2063 DVKGRYMLQGIVVNEKIGQGAQGEVY--RCSCNGQEMAKKTVN----LPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVSKYLKRNKVSIKERLKI-ALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEG 2662
D G+Y L + +G G+ G V+ R + NG+ A KT+ + + Q+ +E + HP ++ + T DS+Q+ + ++ ++ L++++ K A +V AL+YLH + I++RDLK NILLD N ++ + D+GF K + ++ GTP +IAPE+V Y+ VD +S+G+L++ + G
Sbjct: 78 DTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWG------TFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAG 279
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700]) HSP 1 Score: 88.5817 bits (218), Expect = 5.139e-19 Identity = 60/205 (29.27%), Postives = 108/205 (52.68%), Query Frame = 2
Query: 2072 GRYMLQGIVVNEKIGQGAQGEVY--RCSCNGQEMA----KKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVSKYLKRNKVSIKERLKI-ALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEG 2662
G+Y LQ + +G G+ G V+ R NG+ A KK + + + Q+ +E + HP ++ + T D++QI + ++ ++ L++++ K A +V AL+YLH + I++RDLK NILLD N ++ + D+GF K + ++ GTP +IAPE+V Y+ +D +S+G+L++ + G
Sbjct: 80 GKYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWG------TFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAG 278
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124]) HSP 1 Score: 84.3445 bits (207), Expect = 1.132e-17 Identity = 62/206 (30.10%), Postives = 104/206 (50.49%), Query Frame = 2
Query: 2069 KGRYMLQGIVVNEKIGQGAQGEVY--RCSCNGQEMA----KKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVSKYLKRNKVSIKERLKI-ALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEG 2662
KG+Y L + +G G+ G V+ R NG+ A KK + M Q+ +E L +HP L+ + T D++ I + ++ ++ L++++ K A +V AL+YLH I++RDLK NILLD N ++ + D+GF K + + GTP +IAPE++ Y+ VD +S G+L++ + G
Sbjct: 62 KGKYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWG------TFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAG 261
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: SNF1 (AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase [Source:SGD;Acc:S000002885]) HSP 1 Score: 83.5741 bits (205), Expect = 6.116e-17 Identity = 59/192 (30.73%), Postives = 107/192 (55.73%), Query Frame = 2
Query: 2111 IGQGAQGEVYRC--SCNGQEMAKKTVNLPMNQLND----IAEEVYYSYLFQHPRLLPLIAVSITDSTELDSK-QISIFAPLMKTDVSKYL-KRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSN--HSFVGTPVHIAPEIVRKAIY-DFKVDIYSYGMLLWYL 2653
+G+G+ G+V + GQ++A K +N + +D I E+ Y L +HP ++ L V + SK +I + ++ Y+ +R+K+S +E + Q+ A++Y HR +I+HRDLK N+LLD++ NV +AD+G M N + G+P + APE++ +Y +VD++S G++L+ +
Sbjct: 61 LGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDV-------IKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVM 245
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: YPL150W_mRNA (Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study [Source:SGD;Acc:S000006071]) HSP 1 Score: 83.9593 bits (206), Expect = 6.705e-17 Identity = 63/191 (32.98%), Postives = 99/191 (51.83%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLND--IAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSN--HSFVGTPVHIAPEIVRKAIYD-FKVDIYSYGMLLWYLAEG 2662
++IG+G+ G+VY + V L + ND I EV+Y F P + L V +T+S + + + P K L ++S+ E ++ Q++ A+ Y H +HRDLKL NILLD N N L D+GF + + GT V++APE++ + YD FK+DI+S G++L+ L G
Sbjct: 45 KQIGEGSFGKVYLAL---HRPTHRKVCLKTSDKNDPNIVREVFYHRQFDFPYITKLYEVIVTESKVWMALE---YCP-GKELYDHLLSLRRISLLECGELFAQISGAVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPELIERRTYDGFKIDIWSLGVILYTLITG 228
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO44458 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVW1]) HSP 1 Score: 194.897 bits (494), Expect = 3.101e-51 Identity = 209/863 (24.22%), Postives = 384/863 (44.50%), Query Frame = 2
Query: 368 PAIAIVGQVKAGKSTFVNVLLRKNVVCQAYE---RCTARLTRLTYSSQNYVEIL----DENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFI------SKLXXXXXXXXXFSDPIKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEE-------ILFHFDLFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIE------EELF-----------EKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEK-APDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCS--CNGQEMAKKTVNLPMNQ-LNDIAEEVYYS-YLFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
P I +VGQ K +N LL + V+ + + R+ R+ Y + + V ++ E L + +P+ L+LNDE++ + + + + L+ G ++ SP E N+ + +LPI++Y I+ + + D A+LL++K P L I +F+ L T + + AE++ + F++L+ ++ E P A + +D K + ++ +F LF F + ++ L + + EA M + L+ IT A D + + I T R++E EELF E+IK VI S+ +L ++++ +E + G+ + N + I + ++ + + ++ +E + + FV + Q+ D++E + ++ A ++L+ ++ + Y+ S++ + K+ Q I L G K VD WK + A++ L + LA+ +C H +F + ++ +EE R ++ + AP A L + + ++ + ++ ++G+G G VY C A K+V P ++ ND+A E +Y+ L H R++ +I S+ D + ++ + ++ D+ + +K +S + R+ +A+ V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y+ G+LLWY+ GT R P A Q LW + +RPERL +E W LM+ACW +PS RP
Sbjct: 64 PTIIVVGQTCFAKVCVINELLGEPVLPSVEDLEGDRSWRMIRIKYGNISNVSLVLPDSFELAAALNAYEGCWQCVPRGDLELNDEEKADPAMASAVAEISLNHALLKAGAQLVCSPSNPEGDA-ENIFSACCEDVLPILVYSIE-QDFLSDKDEAELLQIKALAPDLPI-FFVKCSRKKPDLTNSMTEYAQHEAIEEFAEARTRI-FEQLRKIGYLT------QESPEQKKALQHEVLDIRNAKAILDSVIPKSMLIENFSLFPCFLLFVRQVLQFH----LVEAATVMNDAHCRALSLFITTA---FDMAR---DMIITPRRLEYAKEKEEELFLALMETATRKQEEIKEVIKSTIENLSPQILKEVESLEFRGVECSGEQKLLNPKDLDHCTFQIQELVLGRINKAVAGNMISSVEYLRESFVGT--LQRCIDSLEKMDSDSRRNACEYTSAT--------VALKHVIDAAYQVEVTYRASSSLARLLWEKMKQAI--------QTLPGKTPPK--VD---SAWKRKVAQDMLTSLSETRLAKHICLQFRTRLIKSHESFTSCMRMLEANHTGRLEKTEEQRMKVRKSHAPKIARLALESWSLRDVVLYGMPQLSREVGRGQYGVVYACDRWAGRHPCAIKSVVPPDDKHWNDLALEFFYTRSLPLHDRVVSIIG-SVIDYSYGGGSSPAVLLVMDRLQRDLYQGIKAG-LSFRARMHVAVDVVEGIRFLHSQGLVHRDIKLKNVLLDSKNRGKITDLGFCKPEAMMSGSIVGTPIHMAPELF-SGHYDNSVDVYALGILLWYICAGTVRLP-LAFEQCASKDHLWNAVRRGVRPERLANFDEECWMLMEACWSGDPSARP 879
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49815 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG13]) HSP 1 Score: 145.976 bits (367), Expect = 1.032e-39 Identity = 72/198 (36.36%), Postives = 117/198 (59.09%), Query Frame = 2
Query: 2246 HPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESV 2839
HP +LPL+ I +S ++ I + M +D+ + L R S+++RL+I L VA AL+YLH ++HRD+KL N+L+D+ + L D+G CK+ + +S VGTP +APE+V++ Y+ VD+Y++G+L+W + EG G PR + +L + + +PERLD W LM+ CW P RP+ + +
Sbjct: 11 HPNILPLVCTVIQPGL-CNSIKVLIVSERMASDLHRALPR-LTSLRKRLEILLDVARALKYLHSLDLIHRDVKLQNVLVDEKSQGSLTDFGLCKAEGVMENSLVGTPTSMAPEMVKQN-YNKSVDVYAFGILMWRVCEGQGNQPRNIALHPIPIIMLVRNALEDRKPERLDRFMGPCWNLMERCWATVPDQRPNFQEI 205
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49816 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG14]) HSP 1 Score: 152.14 bits (383), Expect = 3.303e-38 Identity = 124/445 (27.87%), Postives = 195/445 (43.82%), Query Frame = 2
Query: 89 NLNQAIHEYRENRERLLRIQSSTKEAFSQIT---------EILKPTTAELLEC-------VNIDNIAHIASDLGVINKPTEEIEISAE-----EFLNKTIYEKQDVNQKVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRT------EEILF--HFDLFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDL 1336
+L + E+R NR L +I T + F I E+++ T L +N++NI + + +E + AE +FL +T PA+ + GQ GKS+ +N L VV + CTAR+ R+TYS YV ++ +G LER++L IP+++++LN +DR +N V AG+ FL+ GID+IDSPG SEN L L +N +KSILP +IYV+DG L ++ P D D+ + ++P++ ESK + KL FI P FHG S + ++ K + E LF + D F + L F + + C+++ + L+ I +A L KE + I IR+ E + E I I + D+
Sbjct: 3 SLEEVFKEFRRNRSSLQQIHEDTLKCFQSIEKSLADKKHEELVQEMTTTLASQQQVDGSDINLENIQLVTGGESIATNLSESLYTEAERSKVSKFLTQT---------------PALIVTGQTNCGKSSIINEFLGARVVPTKAQPCTARIVRMTYSETPYVRLVKRDGTELERRELKSNKIPREFIELNIDDRDDEKRVNATVEAGLCVDFLKAGIDVIDSPGTSENDVLDELVRNQMKSILPFVIYVVDGHN------------LLSSSPAKTDSSDEESDDDDNDESVKQAEPVQ--ESKKRKVYDKLVKKGFIIPCEGGRDAHPNFHGLSAWRIGEFNKRMKMNPAWDDSEGLFKEYMDAFHRLHTCLHDFTKSSLTACVENTCNTLTSVLSRCLSFFIKKANFLKQGKKETMVMINRIRQEELTVHENILRQIEKQRLDI 418
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49580 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGQ2]) HSP 1 Score: 117.857 bits (294), Expect = 5.882e-27 Identity = 87/293 (29.69%), Postives = 147/293 (50.17%), Query Frame = 2
Query: 371 AIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKK-LNKPTIPKKYLQLNDEDRTKRSE-INKIVRAGIKSQFLEYG-IDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIKL--------AESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEEILFHFDLFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITR 1216
AI +VGQ +GKS+ +N LL + A CT+R+ R+ YS NYVE+ NG+ ++ K+ K IP+ + L+D+ + +E + +V+ G+ + L G ++++D+PG+SEN L + + I IL ++IYVIDG +S++ D L LK + + I + +K+DT+ D E+KM A+K L I + + +C FHG S + + R ++I H FEV SFL + + ++ L + D+L +I+ R
Sbjct: 94 AILVVGQTNSGKSSLINELLGGTYLPTAEIPCTSRIVRICYSDNNYVEVQGPNGECVQGKQSFGKKRIPRDEIALDDDKKRSDAEWVRCVVKVGLNNSLLRGGHLELVDAPGMSENEVLDQIVQECIHGILQVVIYVIDGNSSLRTQDREFLFSLKERIDSIPIFFVCNKVDTNAKAAEFDRDSDDSDDDSSLDNVETKMRQAYKALVGYGLIDSDIQ-LEDCAAFHGISTH----EVRKARHKKI--HNQFTDAFEVMKSSFLTF-----LDNSLNANLGYTTDLLLRILQR 374
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO25348 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DWR2]) HSP 1 Score: 93.2041 bits (230), Expect = 2.310e-22 Identity = 43/128 (33.59%), Postives = 71/128 (55.47%), Query Frame = 2
Query: 2480 LDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLIL 2863
+D+ + L D+G CK+ + +S VGTP +APE+V++ Y+ VD+Y++G+L+W + EG G PR + +L + + +PERLD W LM+ CW P RP+ + + + IL
Sbjct: 1 VDEKSQGSLTDFGLCKAEGVMENSLVGTPTSMAPEMVKQN-YNKSVDVYAFGILMWRVCEGQGNQPRNIALHPIPIIMLVRNALEDRKPERLDRFMGPCWNLMERCWATVPDQRPNFQEIESDLQEIL 127
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:100144388]) HSP 1 Score: 198.749 bits (504), Expect = 3.992e-52 Identity = 158/600 (26.33%), Postives = 285/600 (47.50%), Query Frame = 2
Query: 1094 FGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNS---IKLFFSK-----LFGTDQIKESV--------DVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQE--MAKKTVNLPMNQ-LNDIAEEVYYSY-LFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
F + L F +N+ EA + + L I +A + + + R+ E ELF + + + + ++ + ++E L E ++ +LE+ + I P NG + + I+ C ++I++ + L Q + + V + +G +LER L+S K + ++ HNV ++++LN+ +++ F F +QIK+ + + EWK + A++ ++ + LA +C + H AF +L + ++ +E++ ++ + AP A L + + ++ + + ++G+G G VY C G A K+V P ++ ND+A E +Y+ L +H RL+ L S+ D + I++ + + D+ LK +S++ERL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ YD VD+Y++G+L WYL G+ + P S+ Q LW + + RPERL +E W+LM+ACW+ +PS+RP
Sbjct: 316 FDRLHRLLVPFTRQVLQNQQVEAANVLNGLHCRCLDLFINQAFDMQRDLQITPRRLEYTREKEGELFSSLMAIANRKQEEMKEMIVETLGSMKEQLLEDAANLEFTDVIVTP-NGEPVTSKEIKSCI------------HLIQELIVVRLNQAVANKLISSVDYLRESFVG--------------TLERCLSSLEK-----STLDSSVHNVTSNHLKQLLNAAYHVEVTFHSGSSVTRFVWEQIKQIIHRITFVNPPAITPEWKRKVAQDAIESLSAAKLARSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLHGKPRLGRELGRGQYGVVYLCESWGGHYPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVDLHG-SVIDHSYGGGSSIAVLLIMERLHRDLYTGLKAG-LSLRERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELF-TGKYDNSVDVYAFGILFWYLCTGSVKLPEAFEKCSSKDQ-LWNNVKKGARPERLPSFDEECWQLMEACWNGDPSLRP 879
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: dstyk (dual serine/threonine and tyrosine protein kinase [Source:NCBI gene;Acc:100144388]) HSP 1 Score: 152.91 bits (385), Expect = 1.646e-37 Identity = 143/600 (23.83%), Postives = 261/600 (43.50%), Query Frame = 2
Query: 1094 FGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNS---IKLFFSK-----LFGTDQIKESV--------DVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQM-AEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQE--MAKKTVNLPMNQ-LNDIAEEVYYSY-LFQHPRLLPLIAVSITDSTELDSKQISIFAPL--MKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRP 2824
F + L F +N+ EA + + L I +A + + + R+ E ELF + + + + ++ + ++E L E ++ +LE+ + I P NG + + I+ C ++I++ + L Q + + V + +G +LER L+S K + ++ HNV ++++LN+ +++ F F +QIK+ + + EWK + A++ ++ + LA +C + H AF +L + ++ +E++ ++ + AP A L + + ++ + + ++G+G G VY C G A K+V P ++ ND+A E +Y+ L +H RL+ L S+ D + I++ + + D+ LK +S++ERL+IAL V E +++LH Q ++HRD+KL N+LLD N + D GFCK A+ + S VGTP+H+APE+ A RPERL +E W+LM+ACW+ +PS+RP
Sbjct: 348 FDRLHRLLVPFTRQVLQNQQVEAANVLNGLHCRCLDLFINQAFDMQRDLQITPRRLEYTREKEGELFSSLMAIANRKQEEMKEMIVETLGSMKEQLLEDAANLEFTDVIVTP-NGEPVTSKEIKSCI------------HLIQELIVVRLNQAVANKLISSVDYLRESFVG--------------TLERCLSSLEK-----STLDSSVHNVTSNHLKQLLNAAYHVEVTFHSGSSVTRFVWEQIKQIIHRITFVNPPAITPEWKRKVAQDAIESLSAAKLARSICSQFRTRLNSSHEAFAASLRQLEEGHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLHGKPRLGRELGRGQYGVVYLCESWGGHYPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERLVDLHG-SVIDHSYGGGSSIAVLLIMERLHRDLYTGLKAG-LSLRERLQIALDVVEGIRFLHGQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGA-----------------------------------------------RPERLPSFDEECWQLMEACWNGDPSLRP 866
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: nek6 (NIMA related kinase 6 [Source:NCBI gene;Acc:101173323]) HSP 1 Score: 106.686 bits (265), Expect = 1.018e-24 Identity = 84/271 (31.00%), Postives = 132/271 (48.71%), Query Frame = 2
Query: 2075 RYMLQGIVVNEKIGQGAQGEVYRCS--CNGQEMAKKTVN----LPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVS---KYLKRNKVSIKERL--KIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVL 2842
R + V KIG+G EVYR + Q +A K V + D +E+ HP ++ + I D+ +++I L D+S KY K+ + I ER K +Q+ AL+++H +++MHRD+K AN+ + V L D G F S + HS VGTP +++PE + + Y+FK DI+S G LL+ +A F + N+ + + + P D+ SD+L EL+ C ++EP RPDI VL
Sbjct: 35 RCSMANFRVERKIGRGQFSEVYRAVRLLDRQSVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNIIKYLDSFIEDN------ELNIVLELADAGDLSQMIKYFKKKRRLIPERTIWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGEVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMA---ALQSPFYGDKMNLLSLCRKIEQCDYPPLPPDQYSDKLRELVSMCINSEPDQRPDIIFVL 296
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: nek7 (NIMA related kinase 7 [Source:NCBI gene;Acc:101170580]) HSP 1 Score: 96.6709 bits (239), Expect = 2.330e-21 Identity = 87/301 (28.90%), Postives = 143/301 (47.51%), Query Frame = 2
Query: 1985 ISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCS--CNGQEMAKKTVNLPMNQLN-----DIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKT-DVSKYL-----KRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYG---FCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESV 2839
+S+ + + Q AE P F L LD+ L + +KIG+G EVYR + +A K + + N ++ D +E+ HP ++ A I D+ +++I L D+S+ + +R + K K +QV AL+++H +++MHRD+K AN+ + V L D G F S + HS VGTP +++PE +R+ Y+FK DI+S G LL+ +A F + N+ + + + P D S EL +L+ C + +P RPDI V
Sbjct: 1 MSMDMQPQGQQAETPP-FQPQKPLQLDMDYS-SLANFQIEKKIGKGQFSEVYRARYILDNTPVALKKIQI-FNLMDAKARQDCIKEIDLLKQLNHPNVIKYHASFIEDN------ELNIVLELADAGDLSRMINHFKNQRRLIPEKAVWKYFVQVCRALEHMHSRRVMHRDIKPANVFVTATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERLRENGYNFKSDIWSLGCLLYEMA---ALQSPFYGDKMNLYSLCTKIQQCDYPPLPSDHYSQELRDLVDMCINPDPEKRPDITYV 289
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000015480.2 (serine/threonine-protein kinase PAK 2 [Source:NCBI gene;Acc:101169249]) HSP 1 Score: 94.7449 bits (234), Expect = 8.916e-20 Identity = 62/194 (31.96%), Postives = 99/194 (51.03%), Query Frame = 2
Query: 2105 EKIGQGAQGEVYRC--SCNGQEMAKKTVNL---PMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSN---HSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEG 2662
EKIGQGA G VY GQE+A K +NL P +L I E+ ++P + V+ DS + + + L ++ + + + + +V +AL++LH Q++HRD+K N+LL + +V L D+GFC + + VGTP +APE+V + Y KVDI+S G++ + EG
Sbjct: 206 EKIGQGASGTVYTAIDVSTGQEVAIKQINLQKQPKKEL--IINEILVMKELKNPNI-----VNFVDSFLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCREVLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEG 392
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000056697.1 (SMESG000056697.1) HSP 1 Score: 1917.12 bits (4965), Expect = 0.000e+0 Identity = 938/940 (99.79%), Postives = 940/940 (100.00%), Query Frame = 2
Query: 56 MAVFDEDKTRQNLNQAIHEYRENRERLLRIQSSTKEAFSQITEILKPTTAELLECVNIDNIAHIASDLGVINKPTEEIEISAEEFLNKTIYEKQDVNQKVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEEILFHFDLFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLILENCI 2875
MAVFDEDKTRQNLNQAIHEYRENRERLLRIQSSTKEAFSQITEILKPTTAELLECVNIDNIAHIASDLGVINKPTEEIEISAEEFLNKTIYEKQDVNQKVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLDTDDTTETEFSDPIKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEEILFHFDLFGKFEVALQSFL+INFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENEN+FVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLILENCI
Sbjct: 1 MAVFDEDKTRQNLNQAIHEYRENRERLLRIQSSTKEAFSQITEILKPTTAELLECVNIDNIAHIASDLGVINKPTEEIEISAEEFLNKTIYEKQDVNQKVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLDTDDTTETEFSDPIKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEEILFHFDLFGKFEVALQSFLMINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENRFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLILENCI 940
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000056719.1 (SMESG000056719.1) HSP 1 Score: 1003.82 bits (2594), Expect = 0.000e+0 Identity = 499/849 (58.78%), Postives = 663/849 (78.09%), Query Frame = 2
Query: 68 DEDKTRQNLNQAIHEYRENRERLLRIQSSTKEAFSQITEILKPTTAELLECVNIDNIAHIASDLGVINKPTEEIEISAEEFLNKTIYEKQDVNQKVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEEILFHFDLFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFK 2614
D+ +TR+NL + I +YR+NRERL++IQSSTK+ F QITEILK T LL+CV+ +N+ +IA+DLG N +I ++ E+F K+++EKQ V+IGNPAIA+VGQVK+GKSTFVN LLRKNVV QA+ERCTAR+TR+TYS +N+VEI+ G +L+RK LN TIPK++LQL + R EINK ++AGI S FL+ GIDIIDSPGLSEN TL NLSKNMIKSILP+MIYVIDGRTSVKQTDI+DLLELKNAVP LQIIYF+SKLDTDD +ETE +DPIKLAE KM++AFKKLQ+NNFIP +F HWSEC YFHG SLY +MDY +N RT E LFH++LF KFE L +LL NF+NKI E C+ +++FQM+V+TKII RA++LSDF + N + I I++IEE+L++KIK + SK L LI+RL++ES+ I+ PI ++ YPN +++P +G+V +K+ I+QCQ +I+S++CQGLENVIK+FVE EL+QKY +AI+ Q+ RMK++I V ++ GKT Y + L+R +A YKFN LSN +G+N IMK M I +SIK F + ++SVDVK +WK +QAK+CL+RCD LA+EVCK+L+++F KHN FL ++ EN +V KKI +S+EIR ++AEKAP FA LLML+LDVKG+Y LQ + E+IG G+QG ++RC C+G+E+AKK + ++ + +IAEE+YYSY F+HP LLP +AV+I D+ E+DSK+++I++PLMKTD+ YL NK + R+ IA+Q+AEALQYLH IMHRDLKLANILL+++N+VFLADYGFCKS AL+++SFVGTP+HIAPEI+ K YD+K
Sbjct: 7 DDQRTRENLTRVIKDYRQNRERLVKIQSSTKKTFDQITEILKSDTGSLLDCVDSNNLNNIAADLG--NFEDSDI-LADEQFYLKSVFEKQ-----VEIGNPAIAVVGQVKSGKSTFVNTLLRKNVVPQAFERCTARITRVTYSMKNFVEIISNEGVILKRKSLNTTTIPKRFLQLKENVRIDEEEINKQIKAGIHSNFLKCGIDIIDSPGLSENETLNNLSKNMIKSILPVMIYVIDGRTSVKQTDISDLLELKNAVPNLQIIYFVSKLDTDDLSETENADPIKLAELKMDIAFKKLQFNNFIPLTFSHWSECNYFHGCSLYAFMDYTQNSRTPETLFHYNLFCKFEENLHHYLLQNFRNKIEEVCNFLIDFQMEVMTKIINRAQMLSDFNRINFDEINRIKRIEEKLYKKIKSAVKDSKIHLKSCLIKRLKNESDVIVKPISEIIYPNHLNIPLDGIVSEKQQIKQCQSIIISNVCQGLENVIKRFVEEELFQKYLEAIQAQIPFRMKNKISVTKS---GKTNYGLCLDRRMAEIYKFNISNNLSNLDGNNTIMKFMNVIRSSIKGFLMTGLKIEFSQKSVDVKDPKWKMKQAKKCLERCDFKILADEVCKNLLEEFYKKHNEFLAVMDLENFYVQKKIELSDEIRQKLAEKAPIFAELLMLSLDVKGKYFLQNVEEKEEIGSGSQGTIHRCICDGKELAKKKYIVNIDSIEEIAEEIYYSYSFEHPHLLPFLAVAIIDTEEIDSKEVAIYSPLMKTDLYNYLCHNKTKLSHRISIAIQIAEALQYLHSHNIMHRDLKLANILLNEDNSVFLADYGFCKSTALTHYSFVGTPLHIAPEIIMKNNYDYK 844
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000056718.1 (SMESG000056718.1) HSP 1 Score: 930.628 bits (2404), Expect = 0.000e+0 Identity = 472/925 (51.03%), Postives = 655/925 (70.81%), Query Frame = 2
Query: 92 LNQAIHEYRENRERLLRIQSSTKEAFSQITEILKPTTAELLECVNIDNIAHIASDLGVINKPTEEIEISAEEFLNKTIYEKQDVNQKVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDP-------IKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEEILFHFDLFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLTALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKA-PDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVL 2842
+NQA EYRENR+ L+ IQ+ T+ AF +T+ILKP+TAELLEC+NI++++ ++ ++ + ++++ DV + V NPAIAIVGQVKA KST +NVLLRK VVCQA+ RCTAR+TRLTYS +NYVE+ D +G +L+RK L P IP ++++LN+ DR+ EI K V+AGI +FL GID+ID+PGL+E++ L+NLSK +K+ILPIMIYVIDG TSVKQTD++DLLELKNA+P L+IIYFISKLD+D +TE SDP I+L+ K+ +AFK+LQ NFIP ++ HWSECPYFHGASLY MDY+ ++++ EILF+ +LF +FE L FLL++F+N I A S++ F MDVL KII+R + D ++EN N I I++IEEELFE IK V+SS K L + LI++ + ES++I + D EYP+SI VP++G+ ID I CQ I+S +C GLE +I++FVE EL+ KYR +E M ++ +K G+ PY M L +IL NYK N N E + + KL+ IL+SIK+F K+F + +K DVKS +WK Q K CL CD S LA+ VC +LI++ +N H AF LALE E K K I +S+ I+ + + P F+ LLM TLD+KGRYM++ + +E+IGQG+Q VYRC+ NG+E+A KT + ++L++I++EVYYSYLF+H LLP IA+SI + +S Q+SIF PLMK+D ++ +N+VS+ +RL IALQ AEALQYLH Q IMHRDLKLANILLD+ +NV+LADYG CKS A++N++ VGTP+H+APE+++ + YD K+DIYS+G+LLWYL EG G HP+ V S + +VL+ + ++RPERL+ + DELW+LM ACWD P +RP+ +S++
Sbjct: 15 INQASQEYRENRKALIDIQTRTRTAFLNLTDILKPSTAELLECININDLSEAFAEFTLVQNEN----VPNDKYV-------PDVEKNVSC-NPAIAIVGQVKAAKSTMINVLLRKTVVCQAFSRCTARITRLTYSEENYVELFDSDGTLLKRKLLRAPKIPARFVRLNENDRSNIKEIRKEVKAGINCKFLMSGIDLIDTPGLNEHSLLSNLSKETVKNILPIMIYVIDGNTSVKQTDLSDLLELKNAIPDLKIIYFISKLDSDISTEQ-LSDPEEIEKMKIELSIEKLSIAFKRLQNQNFIPKTYNHWSECPYFHGASLYKIMDYFNHQQSPEILFNLELFNRFENELSLFLLVHFENIITTAAYSLIYFHMDVLAKIISRGIKIKDSSEENQNQIERIKRIEEELFENIKNVLSSQKLYLKEILIKKFKTESDSIYKLVQDCEYPSSIRVPDSGITIDNNTIRLCQKFIVSIICFGLEQLIERFVEDELFSKYRSKVENHFNDNMDKKLYGKNSKFSGRNPYDMCLRKILTENYKCNFKVNPKNLEDMSSMRKLINNILSSIKIFLWKIFEVNSLKGCKDVKSQKWKHNQVKYCLLNCDFSKLADNVCINLIENLQNCHEAFNLALEIERKHFQKSIQISDNIKQSLKKNHWPVFSVLLMETLDIKGRYMMKDVKRHEEIGQGSQASVYRCTVNGKELAMKTRYVKADKLSEISDEVYYSYLFEHRHLLPFIAISI--KLQYNSAQVSIFTPLMKSDALDFIIQNEVSLVKRLMIALQTAEALQYLHNQSIMHRDLKLANILLDNEDNVYLADYGCCKSTAIANNTIVGTPIHMAPEVIQNS-YDDKIDIYSFGILLWYLVEGKGNHPKHLSVHSEVFRVLYLAAHKDVRPERLENMPDELWDLMSACWDKNPVLRPNTDSIV 923
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000056716.1 (SMESG000056716.1) HSP 1 Score: 890.182 bits (2299), Expect = 0.000e+0 Identity = 453/929 (48.76%), Postives = 638/929 (68.68%), Query Frame = 2
Query: 83 RQNLNQAIHEYRENRERLLRIQSSTKEAFSQITEILKPTTAELLECVNIDNIAHIASDLGVINKPTE-EIEISAEEFLNKTIYEKQDVNQKVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEEILFHFDLFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLT-ALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLIL 2863
+NL Q I Y+ + + +L IQ +TK AF IT+IL P + LLEC+N+DN+ +I + G + E+ ISA + + + N ++ NP IAIVG VKAGKST VN+LLRKNVV QA++ CTARLTR+TYS +NYVE+++ + +++ERKKL IPK ++LNDEDR+ E+NK++R GIKS+FL+ GID+IDSPGL+EN L L N+I +LP+MIYVIDG+TSVKQTDI+++L LK ++P L IIYFI++LDTDD +E +D IK A+ K++ F+KLQ +N IP +F H+SEC FHGASLY YMDY +++E FH + F KFE L L NF+ +I A S+++FQMDVLTKII+RA+ DFT ENL+ IFT+RK+EE L +K I++SK LI RL++RL++ES+ II+ I D+E+P SI +PEN K+ + CQ I+ +C+ L+N+I FV+ EL + + + E ++ ++ +++ ++ + K+PYR+ LER L YK++ L + N+ I N +K + LF +D ++ D+ S W+ Q K L CD LA+ +C +++ D KH+ FL+ LE E K + K+I++SE IR +++ + F LLM TLD++ +Y+++ V E IGQG+QG VYRC CNG+E AKK + +P + L I+EEVYYSYLF+HP LLPLIAV++ D+ D +ISI+ PLMK D+ Y+K+N ++++++LKI+L+VA AL+Y+H Q IMHRDLKLANILLD+ NNV+LADYGFCKS+ALSN+SFVGT VHIAPEIVR++ YD K+DIYS+GMLLWYLA+G P FA QS +VL T N+RPERL+ I D LW+LM CWD PS RP+I S++ I +L
Sbjct: 7 HENLRQTIQLYQNDLKNVLVIQENTKTAFQHITDILDPISENLLECINLDNLLNIFNVCGNTETLNDIELAISALRYDSGLVENSFRTNNEIHKENPTIAIVGSVKAGKSTLVNLLLRKNVVRQAHKTCTARLTRITYSEENYVELVNIHDQIIERKKLKNKPIPKYIVELNDEDRSNPDEVNKLIRVGIKSKFLKSGIDLIDSPGLNENHVLNLLISNIINKVLPVMIYVIDGQTSVKQTDISNILSLKVSIPNLNIIYFITRLDTDDVSELIENDHIKTAKDKLDFTFRKLQRSNLIPKTFNHYSECHNFHGASLYSYMDYCNKIKSQETDFHNEQFCKFESDLNRILSENFEREILTATKSLIDFQMDVLTKIISRAKQFVDFTNENLDEIFTMRKVEERLHNDLKSEINNSKPLLIDRLMKRLDNESDLIIDLIADMEFPKSIIIPENK-AFTKKNAKFCQKHIIDLICKDLDNLIDNFVQDELNKNFENCFEAHLSPKIINKLKLYSCRLSNKSPYRLCLERNLTKYYKYDLLGLKIKNSSF---------SIWNFLKNIITGLFRSDLSNDTFDINSRHWRIGQTKIILNLCDKDLLAKNICNNMLHDLNVKHDRFLMNLEKEFKVIQKEINLSETIRDKISNETSSFTLLLMRTLDLQSKYLMKDSVEKEMIGQGSQGTVYRCVCNGKEYAKKKIIVPTDLLETISEEVYYSYLFEHPNLLPLIAVTVNDNIRFDCIEISIYTPLMKIDLENYMKKNILTLEQQLKISLEVANALKYIHNQNIMHRDLKLANILLDEQNNVYLADYGFCKSLALSNYSFVGTFVHIAPEIVRQSKYDQKIDIYSFGMLLWYLAKGDCEPPLFANCQSTTVKVLLEVTNKNVRPERLENIPDNLWDLMNECWDQNPSNRPNINSIISTIQDLL 925
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000056716.1 (SMESG000056716.1) HSP 1 Score: 889.797 bits (2298), Expect = 0.000e+0 Identity = 453/929 (48.76%), Postives = 638/929 (68.68%), Query Frame = 2
Query: 83 RQNLNQAIHEYRENRERLLRIQSSTKEAFSQITEILKPTTAELLECVNIDNIAHIASDLGVINKPTE-EIEISAEEFLNKTIYEKQDVNQKVDIGNPAIAIVGQVKAGKSTFVNVLLRKNVVCQAYERCTARLTRLTYSSQNYVEILDENGKVLERKKLNKPTIPKKYLQLNDEDRTKRSEINKIVRAGIKSQFLEYGIDIIDSPGLSENATLTNLSKNMIKSILPIMIYVIDGRTSVKQTDIADLLELKNAVPKLQIIYFISKLXXXXXXXXXFSDPIKLAESKMELAFKKLQYNNFIPTSFKHWSECPYFHGASLYCYMDYYKNKRTEEILFHFDLFGKFEVALQSFLLINFKNKIFEACDSMLNFQMDVLTKIITRARVLSDFTKENLNHIFTIRKIEEELFEKIKGVISSSKNDLIKRLIERLEDESEAIINPIGDLEYPNSISVPENGMVIDKRLIEQCQGVIMSSLCQGLENVIKQFVESELYQKYRDAIEVQVTSRMKDEIGVHEAKCLGKTPYRMSLERILASNYKFNSLT-ALSNTEGHNVIMKLMQEILNSIKLFFSKLFGTDQIKESVDVKSHEWKTQQAKECLKRCDHSTLAEEVCKSLIDDFENKHNAFLLALENENKFVHKKISVSEEIRTQMAEKAPDFAGLLMLTLDVKGRYMLQGIVVNEKIGQGAQGEVYRCSCNGQEMAKKTVNLPMNQLNDIAEEVYYSYLFQHPRLLPLIAVSITDSTELDSKQISIFAPLMKTDVSKYLKRNKVSIKERLKIALQVAEALQYLHRQQIMHRDLKLANILLDDNNNVFLADYGFCKSMALSNHSFVGTPVHIAPEIVRKAIYDFKVDIYSYGMLLWYLAEGTGRHPRFARVQSNIAQVLWASTEHNMRPERLDEISDELWELMQACWDNEPSVRPDIESVLCKITLIL 2863
+NL Q I Y+ + + +L IQ +TK AF IT+IL P + LLEC+N+DN+ +I + G + E+ ISA + + + N ++ NP IAIVG VKAGKST VN+LLRKNVV QA++ CTARLTR+TYS +NYVE+++ + +++ERKKL IPK ++LNDEDR+ E+NK++R GIKS+FL+ GID+IDSPGL+EN L L N+I +LP+MIYVIDG+TSVKQTDI+++L LK ++P L IIYFI++LDTDD +E +D IK A+ K++ F+KLQ +N IP +F H+SEC FHGASLY YMDY +++E FH + F KFE L L NF+ +I A S+++FQMDVLTKII+RA+ DFT ENL+ IFT+RK+EE L +K I++SK LI RL++RL++ES+ II+ I D+E+P SI +PEN K+ + CQ I+ +C+ L+N+I FV+ EL + + + E ++ ++ +++ ++ + K+PYR+ LER L YK++ L + N+ I N +K + LF +D ++ D+ S W+ Q K L CD LA+ +C +++ D KH+ FL+ LE E K + K+I++SE IR +++ + F LLM TLD++ +Y+++ V E IGQG+QG VYRC CNG+E AKK + +P + L I+EEVYYSYLF+HP LLPLIAV++ D+ D +ISI+ PLMK D+ Y+K+N ++++++LKI+L+VA AL+Y+H Q IMHRDLKLANILLD+ NNV+LADYGFCKS+ALSN+SFVGT VHIAPEIVR++ YD K+DIYS+GMLLWYLA+G P FA QS +VL T N+RPERL+ I D LW+LM CWD PS RP+I S++ I +L
Sbjct: 8 HENLRQTIQLYQNDLKNVLVIQENTKTAFQHITDILDPISENLLECINLDNLLNIFNVCGNTETLNDIELAISALRYDSGLVENSFRTNNEIHKENPTIAIVGSVKAGKSTLVNLLLRKNVVRQAHKTCTARLTRITYSEENYVELVNIHDQIIERKKLKNKPIPKYIVELNDEDRSNPDEVNKLIRVGIKSKFLKSGIDLIDSPGLNENHVLNLLISNIINKVLPVMIYVIDGQTSVKQTDISNILSLKVSIPNLNIIYFITRLDTDDVSELIENDHIKTAKDKLDFTFRKLQRSNLIPKTFNHYSECHNFHGASLYSYMDYCNKIKSQETDFHNEQFCKFESDLNRILSENFEREILTATKSLIDFQMDVLTKIISRAKQFVDFTNENLDEIFTMRKVEERLHNDLKSEINNSKPLLIDRLMKRLDNESDLIIDLIADMEFPKSIIIPENK-AFTKKNAKFCQKHIIDLICKDLDNLIDNFVQDELNKNFENCFEAHLSPKIINKLKLYSCRLSNKSPYRLCLERNLTKYYKYDLLGLKIKNSSF---------SIWNFLKNIITGLFRSDLSNDTFDINSRHWRIGQTKIILNLCDKDLLAKNICNNMLHDLNVKHDRFLMNLEKEFKVIQKEINLSETIRDKISNETSSFTLLLMRTLDLQSKYLMKDSVEKEMIGQGSQGTVYRCVCNGKEYAKKKIIVPTDLLETISEEVYYSYLFEHPNLLPLIAVTVNDNIRFDCIEISIYTPLMKIDLENYMKKNILTLEQQLKISLEVANALKYIHNQNIMHRDLKLANILLDEQNNVYLADYGFCKSLALSNYSFVGTFVHIAPEIVRQSKYDQKIDIYSFGMLLWYLAKGDCEPPLFANCQSTTVKVLLEVTNKNVRPERLENIPDNLWDLMNECWDQNPSNRPNINSIISTIQDLL 926 The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017847 ID=SMED30017847|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2980bpback to top protein sequence of SMED30017847-orf-1 >SMED30017847-orf-1 ID=SMED30017847-orf-1|Name=SMED30017847-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=941bp MAVFDEDKTRQNLNQAIHEYRENRERLLRIQSSTKEAFSQITEILKPTTAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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