DNA polymerase theta

Overview


Name	DNA polymerase theta
Smed ID	SMED30017838
Length (bp)	5539

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of DNA polymerase theta (SMED30017838) t-SNE clustered cells

Violin plots show distribution of expression levels for DNA polymerase theta (SMED30017838) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DNA polymerase theta (SMED30017838) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DNA polymerase theta (SMED30017838) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30017838

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30017838	SMESG000034022.1	SmedASXL_005642	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X1 cell	SMED30017838	SMESG000034022.1	SmedASXL_013053	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
pharynx	SMED30017838	SMESG000034022.1	dd_Smed_v4_42151_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

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BLAST of DNA polymerase theta vs. Ensembl Human
Match: POLQ (DNA polymerase theta [Source:HGNC Symbol;Acc:HGNC:9186])

HSP 1 Score: 273.478 bits (698), Expect = 6.023e-73
Identity = 153/293 (52.22%), Postives = 207/293 (70.65%), Query Frame = 2

Query:  122 NVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRET-----QIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            N  LP+ V  +Y+  G+  +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE++KK LFILP+VSV+KEK  Y Q LF  +G+K+ G+MG  SP    +++DIAVCTIE+AN L+NRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTKI Y ++       +   +     QI+GMSATLPNL +VA WL AELY  D+RP+PL E +K  + IYD       +R F  P   +K DED ++ LC ETI + H  L+FCP+KKWCE ++  +A+E 
Sbjct:   73 NWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEG-KNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSS--MKLVREFE-PMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREF 361

HSP 2 Score: 235.343 bits (599), Expect = 2.570e-61
Identity = 177/532 (33.27%), Postives = 264/532 (49.62%), Query Frame = 2

Query: 4061 FSFIEMNISYIIDQAPGFGVNFSVME--SQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPV-----------------QGIFNGGKI--TRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPL-FEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPK--------------PIQINWFKLLHLDKRDLFKN---------KAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAIT---ADYKNKSFHRKSLNQ-----------IPAM---------VLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            F  +EM   Y +      G+ FS  E  SQ   ++  +D ++  A+ ++G +F+  S  +++++LF+E++ P                  +GI NG K+   R+ STSK   +  K L+ L  L        E+R +   + K + PL  E C    +      P    + Q  ++TGR+  T PN+Q+VP+              P Q     LL + +    K          + +E   D+     I + R  F    G  ++ ADY QLELRIL+H S D  LI         D+F  +A++W     ES+ D  RQQAKQI YGIIYG+ A+ L EQM I+E+ A   I+ F   + G++QF+  T+  C+++GF++TI GRRRYLP I   NP+ ++HAERQAI++ +QGSAADIVK A V +   +    + +K+   HR+ + Q           +  M         +L LHDE+LYEV    +  +A I+K  ME +  L V L VKVK G  W EL DF V
Sbjct: 2073 FRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLIL------EWRRITNAITKVVFPLQREKCLNPFLGMERIYP----VSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSI-SMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVL--NTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHG-HREGMLQSDQTGLSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV 2590

HSP 3 Score: 194.897 bits (494), Expect = 6.513e-49
Identity = 96/252 (38.10%), Postives = 158/252 (62.70%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFL---IKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNG-KSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLV 1726
            +TP++    T IDW  F+ +      +  RV  LVG+EE FL   +K  V  RT  +H     ++RF++SL+L  L++E   +++ +K+   +G +QSLQ  AA YAGM+T+F NRLGW ++E+L++ FQ+R+ FG+  +L DLVR+SL+NA RAR+ + +G  T++ +A A + E+  +L+ ++PF+SA+     EE       + R +   G K L   EAA  ++ E++M+L++DL  MG++WNP  L+
Sbjct:  654 VTPMFEDW-TTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALL 904

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BLAST of DNA polymerase theta vs. Ensembl Human
Match: POLQ (DNA polymerase theta [Source:HGNC Symbol;Acc:HGNC:9186])

HSP 1 Score: 273.092 bits (697), Expect = 9.229e-73
Identity = 153/293 (52.22%), Postives = 207/293 (70.65%), Query Frame = 2

Query:  122 NVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRET-----QIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            N  LP+ V  +Y+  G+  +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE++KK LFILP+VSV+KEK  Y Q LF  +G+K+ G+MG  SP    +++DIAVCTIE+AN L+NRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTKI Y ++       +   +     QI+GMSATLPNL +VA WL AELY  D+RP+PL E +K  + IYD       +R F  P   +K DED ++ LC ETI + H  L+FCP+KKWCE ++  +A+E 
Sbjct:  206 NWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEG-KNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSS--MKLVREFE-PMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREF 494

HSP 2 Score: 235.343 bits (599), Expect = 2.752e-61
Identity = 177/532 (33.27%), Postives = 264/532 (49.62%), Query Frame = 2

Query: 4061 FSFIEMNISYIIDQAPGFGVNFSVME--SQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPV-----------------QGIFNGGKI--TRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPL-FEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPK--------------PIQINWFKLLHLDKRDLFKN---------KAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAIT---ADYKNKSFHRKSLNQ-----------IPAM---------VLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            F  +EM   Y +      G+ FS  E  SQ   ++  +D ++  A+ ++G +F+  S  +++++LF+E++ P                  +GI NG K+   R+ STSK   +  K L+ L  L        E+R +   + K + PL  E C    +      P    + Q  ++TGR+  T PN+Q+VP+              P Q     LL + +    K          + +E   D+     I + R  F    G  ++ ADY QLELRIL+H S D  LI         D+F  +A++W     ES+ D  RQQAKQI YGIIYG+ A+ L EQM I+E+ A   I+ F   + G++QF+  T+  C+++GF++TI GRRRYLP I   NP+ ++HAERQAI++ +QGSAADIVK A V +   +    + +K+   HR+ + Q           +  M         +L LHDE+LYEV    +  +A I+K  ME +  L V L VKVK G  W EL DF V
Sbjct: 2208 FRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLIL------EWRRITNAITKVVFPLQREKCLNPFLGMERIYP----VSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSI-SMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVL--NTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHG-HREGMLQSDQTGLSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV 2725

HSP 3 Score: 194.512 bits (493), Expect = 8.321e-49
Identity = 96/252 (38.10%), Postives = 158/252 (62.70%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFL---IKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNG-KSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLV 1726
            +TP++    T IDW  F+ +      +  RV  LVG+EE FL   +K  V  RT  +H     ++RF++SL+L  L++E   +++ +K+   +G +QSLQ  AA YAGM+T+F NRLGW ++E+L++ FQ+R+ FG+  +L DLVR+SL+NA RAR+ + +G  T++ +A A + E+  +L+ ++PF+SA+     EE       + R +   G K L   EAA  ++ E++M+L++DL  MG++WNP  L+
Sbjct:  789 VTPMFEDW-TTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALL 1039

[Close]

BLAST of DNA polymerase theta vs. Ensembl Human
Match: POLN (DNA polymerase nu [Source:HGNC Symbol;Acc:HGNC:18870])

HSP 1 Score: 179.489 bits (454), Expect = 6.411e-47
Identity = 143/472 (30.30%), Postives = 237/472 (50.21%), Query Frame = 2

Query: 4046 SLYKHFSFIEMNISYIID--QAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKIT----ASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPK-PIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVIC-NFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSEL 5437
             L++ F  +E+ +  I+   ++    VN   ME     +   +  L+Q A  V+G+ F I S  ++ ++LF +++  +        ++++NS  +       ST + LN L  LHPLP +ILEYR +  +    ++ L  AC K    +ST N       Q  + TGRL++  PN+Q + K PIQI   K         FK K         ED ++  + R+ F +S G   + AD+ Q+ELRIL+H S DP L+  F      D+F  + S+W   P+E +T  DR+Q K++ Y ++YG   + L+  + +   +A Q +  F+  +  +  F ++ I  C + G + +I GRRR LP I + +   R+ AERQA++  +QGSAAD+ K AM+ V  A+ A +   +           +V  +HDE+L+EV    +   A ++++ ME     +V L V +  G  W  L
Sbjct:   53 GLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHL--------LSQRNSLPRTGLQKYPSTSEALNALRDLHPLPKIILEYRQVHKIKSTFVDGLL-ACMKKGSISSTWN-------QTGTVTGRLSAKHPNIQGISKHPIQITTPKN--------FKGK---------EDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTA----------RLVAQIHDELLFEVEDPQIPECAALVRRTMESLE--QVPLKVSLSAGRSWGHL 479

[Close]

BLAST of DNA polymerase theta vs. Ensembl Human
Match: POLN (DNA polymerase nu [Source:HGNC Symbol;Acc:HGNC:18870])

HSP 1 Score: 182.956 bits (463), Expect = 3.894e-46
Identity = 156/564 (27.66%), Postives = 271/564 (48.05%), Query Frame = 2

Query: 3773 IDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIGDRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPK-PIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVIC-NFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCME-----KSYDLKVSLPVKV--KTGTVWSEL 5437
            +D  +  W+++  +   +F D+  KY       + V +N+   +      R++   NV    K      L  L + +C + +    W     L++      + I  +++ +    VN   ME     +   +  L+Q A  V+G+ F I S  ++ ++LF +++  +    N      +    K  ++++  LN L  LHPLP +ILEYR +  +    ++ L  AC K    +ST N       Q  + TGRL++  PN+Q + K PIQI   K         FK K         ED ++  + R+ F +S G   + AD+ Q+ELRIL+H S DP L+  F      D+F  + S+W   P+E +T  DR+Q K++ Y ++YG   + L+  + +   +A Q +  F+  +  +  F ++ I  C + G + +I GRRR LP I + +   R+ AERQA++  +QGSAAD+ K AM+ V  A+ A +   +           +V  +HDE+L+EV    +   A ++++ ME     ++ +L++ +P+KV    G  W  L
Sbjct:  347 LDPRIAAWLIDPSDATPSFEDLVEKY---CEKSITVKVNSTYGN----SSRNIVNQNVRENLK-----TLYRLTMDLCSKLKDYGLWQ----LFRTLELPLIPILAVME-SHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNS---LPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLL-ACMKKGSISSTWN-------QTGTVTGRLSAKHPNIQGISKHPIQITTPKN--------FKGK---------EDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTA----------RLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHL 855

[Close]

Query: 3773 IDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIGDRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPK-PIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVIC-NFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCME-----KSYDLKVSLPVKV--KTGTVWSEL 5437
            +D  +  W+++  +   +F D+  KY       + V +N+   +      R++   NV    K      L  L + +C + +    W     L++      + I  +++ +    VN   ME     +   +  L+Q A  V+G+ F I S  ++ ++LF +++  +    N      +    K  ++++  LN L  LHPLP +ILEYR +  +    ++ L  AC K    +ST N       Q  + TGRL++  PN+Q + K PIQI   K         FK K         ED ++  + R+ F +S G   + AD+ Q+ELRIL+H S DP L+  F      D+F  + S+W   P+E +T  DR+Q K++ Y ++YG   + L+  + +   +A Q +  F+  +  +  F ++ I  C + G + +I GRRR LP I + +   R+ AERQA++  +QGSAAD+ K AM+ V  A+ A +   +           +V  +HDE+L+EV    +   A ++++ ME     ++ +L++ +P+KV    G  W  L
Sbjct:  347 LDPRIAAWLIDPSDATPSFEDLVEKY---CEKSITVKVNSTYGN----SSRNIVNQNVRENLK-----TLYRLTMDLCSKLKDYGLWQ----LFRTLELPLIPILAVME-SHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNS---LPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLL-ACMKKGSISSTWN-------QTGTVTGRLSAKHPNIQGISKHPIQITTPKN--------FKGK---------EDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTA----------RLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHL 855

[Close]

BLAST of DNA polymerase theta vs. Ensembl Celegans
Match: polq-1 (DNA polymerase theta [Source:UniProtKB/Swiss-Prot;Acc:A0FLQ6])

HSP 1 Score: 153.295 bits (386), Expect = 7.697e-37
Identity = 139/462 (30.09%), Postives = 227/462 (49.13%), Query Frame = 2

Query: 4076 MNISY---IIDQAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSE--QMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYL-PDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEK--SYDLKVSLPVKVKTGTVWSEL 5437
            +NI Y   + DQA        +  S I ++++ ++ L++  + ++   FNI S  EV+ +LF  +              R   T+K+          + + HP+ G ILEYR +   + + L PL +   +           I C ++  +STGR+ ++ PNLQ+VPK I  +                A++L I  +E+                +L+ ADY+QLELR+L+H S D  L+    +  D D+F +++ +W         +  R   KQ+ YG+IYG+ A+ LSE  +MSIE+  AE+M+  F   FPGV  +I  T +   K   I TI GRR  +    I E    R+  ER A++ TIQGSA++I KTA+V +++ I      K F  +       +VL +HDE+L E P  ++   +  ++ CM+   S+ L+V + V +KTG  W++L
Sbjct: 1282 LNIFYSGIVFDQA--------LCNSFIYKIRKQIENLEENIWRLAYGKFNIHSSNEVANVLFYRLGLIYPETSGCKPKLRHLPTNKLILE------QMNTQHPIVGKILEYRQIQHTLTQCLMPLAKFIGR-----------IHCWFEMCTSTGRILTSVPNLQNVPKRISSDGMS-------------ARQLFIANSEN----------------LLIGADYKQLELRVLAHLSNDSNLVNLITS--DRDLFEELSIQW---------NFPRDAVKQLCYGLIYGMGAKSLSELTRMSIED--AEKMLKAFFAMFPGVRSYINETKEKVCKEEPISTIIGRRTIIKASGIGEE---RARIERVAVNYTIQGSASEIFKTAIVDIESKI------KEFGAQ-------IVLTIHDEVLVECPEIHVAAASESIENCMQNALSHLLRVPMRVSMKTGRSWADL 1660

HSP 2 Score: 142.895 bits (359), Expect = 1.182e-33
Identity = 77/263 (29.28%), Postives = 144/263 (54.75%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIP 1771
            +TP+ +S+    DW   +++ +       R+  LVG+ EKF++   + GR + +      + RF+S+L L+ L++E S  +V+ K+ + +G LQ+LQ Q+ATYA M+  FC RLGW++L+ L+  F  R++FGV  +L +LV +  ++  RARI  + G+  +S ++     ++ + L  ++P+ S+   D + E  +               ++++ AA  +   ++ +L R +Q +GI    P   + +ENI E  DS +P
Sbjct:  599 VTPINVSVWQECDWHHLFSIFSKLPSDHKRIAKLVGVSEKFILD-QLQGRRNDKLLQ--IHIRFFSALALFDLISEMSIYEVSHKYRIPRGCLQTLQSQSATYAAMIVAFCLRLGWTYLKALLDGFATRLLFGVRSELSELVAIEGIDGQRARILHERGVTCLSHLSACDSSKLAHFLTLAVPYSSSNSNDGLGEWLFGE-----------PRMRVDVAARTLKERARKVLIRRVQELGISVELPKFEENEENIQESCDSGLP 847

HSP 3 Score: 121.324 bits (303), Expect = 4.852e-27
Identity = 91/286 (31.82%), Postives = 158/286 (55.24%), Query Frame = 2

Query:  128 FLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMS--PKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLK-AELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLA 976
            ++   + + Y E  I +LF WQ + +      +  ++L++SAPTSAGK++V+E++  K     +K + F+LPY+SV++EK+   Q+ +    + + GF+G  +  P   L     AVCTIEKA +L NR + +   EE+ ++V+DE+HM+ D  RG  +E +L+K+L  +++  E      + +IIGMSAT+P L  + +WL  A+++   +RPI LQ  +   S++    D +  +R F+         ED ++ L  E+       LV   +K   E  + N+A
Sbjct:   11 WVSSKIIDYYAEQNIKALFDWQIDVLNEARQFE-DQHLIFSAPTSAGKSIVAELLSWKVASTGRKVL-FVLPYISVAREKLHQIQRCWRRDDISVCGFIGPQASNPNEWLG----AVCTIEKAASLTNRALSEDWFEEIGMIVVDEMHMVFDSSRGAHIEHMLSKVLLWNQSALE------KVRIIGMSATIPELYRIGKWLDGAKVFEARFRPIVLQNHIVIGSELRKSGD-NKVLREFS---------EDPLILLTEESFRRNSQTLVMISSKLDAEKTALNIA 274

[Close]

BLAST of DNA polymerase theta vs. Ensembl Celegans
Match: helq-1 (HELicase Q homolog [Source:UniProtKB/TrEMBL;Acc:Q65XX0])

HSP 1 Score: 150.599 bits (379), Expect = 2.347e-36
Identity = 101/290 (34.83%), Postives = 158/290 (54.48%), Query Frame = 2

Query:  131 LPQNVFNQYNELG-ITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIK-TDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            LP+     Y ++  +   + WQ EC+    +LDG +N + S PT AGKTL++E+++L+  +  K+  + +LPYV++ +EK   +  F+  FG    +     G   P      V + V TIEKAN L+N LI  G L+ + ++V+DELHM+GD  RG ILE LL K LY               QI+GMSATLPN++ +   L+A +Y  ++RP+ L E +K    ++   +        + P+  +K TD D I  L L  ++  +  ++FCP KK CE ++  +AK L
Sbjct:  151 LPERDMEMYRKIKKLDKFYDWQQECLSDKRLLDG-ENCILSLPTGAGKTLIAEVLMLREAIVRKRNAILVLPYVAIVQEKISALAPFEDAFGINIEEYASNKGRFPPIKRRKRVSVYVATIEKANMLINSLITQGQLDRVGMVVVDELHMIGDGGRGAILEQLLAKFLYKGT-----------GQIVGMSATLPNIDDLKFALRAFVYSTNFRPVELTEFVKIGQTMHQVSENGDLNPAGDLPTNNLKSTDPDGICQL-LAKLIPKNSAVIFCPNKKNCENVAVLIAKTL 427

HSP 2 Score: 67.0106 bits (162), Expect = 1.417e-10
Identity = 45/160 (28.12%), Postives = 80/160 (50.00%), Query Frame = 2

Query: 1016 IDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLG--WSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGA 1489
            I+W  F  + N+   +E +++   G+EEKF+++  ++    T  +  P+ R  Y +L+L  + N      V E+F VEKG LQ+    + + A  +  F  ++   W  L  L+    +R+      +L+ L+ +  +   RA I FKAG +T+  IA A
Sbjct:  716 INWDLFLLMYNALPSSERKLLAECGLEEKFILEAIITRVDLT--AGTPRMR-LYIALMLQKIWNHEPMYTVAERFGVEKGWLQATLQSSISQAASIAKFSEKITTMWP-LRKLLPELVQRLSEAAQPELLPLMTVDGIKKARAAILFKAGYKTVGMIARA 871

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BLAST of DNA polymerase theta vs. Ensembl Celegans
Match: snrp-200 (Putative U5 small nuclear ribonucleoprotein 200 kDa helicase [Source:UniProtKB/Swiss-Prot;Acc:Q9U2G0])

HSP 1 Score: 69.3218 bits (168), Expect = 2.961e-11
Identity = 69/220 (31.36%), Postives = 119/220 (54.09%), Query Frame = 2

Query:  167 GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXX----------XXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGD--MSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAE---LYVCD--YRPIPLQE 775
            G  SL   QS     +  L   ++L+  APT AGKT V+ + +L+           V   + K+++I P  S+ +E +  F K     G+ +G   GD  MS +  +AT  + VCT EK + +  +  +    + + LL+IDE+H+L D+ RG +LE ++ +      T+++ + N+ E +++G+SATLPN   VA +L+ +   L+  D  YRP+PL++
Sbjct:  471 GYKSLNRIQSRLC--DSALRSKEHLLLCAPTGAGKTNVALLTMLQEIGNHLAEDGSVKLDEFKIVYIAPMKSLVQEMVGSFSKRLAPFGITVGEMTGDAQMSKEQFMAT-QVIVCTPEKYDVVTRKGGERAYNQMVRLLIIDEIHLLHDD-RGPVLESIVVR------TIRQMEQNHDECRLVGLSATLPNYQDVATFLRVKPEHLHFFDNSYRPVPLEQ 680

[Close]

BLAST of DNA polymerase theta vs. Ensembl Celegans
Match: helq-1 (HELicase Q homolog [Source:UniProtKB/TrEMBL;Acc:Q65XX0])

HSP 1 Score: 64.6994 bits (156), Expect = 3.789e-10
Identity = 45/160 (28.12%), Postives = 80/160 (50.00%), Query Frame = 2

Query: 1016 IDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLG--WSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGA 1489
            I+W  F  + N+   +E +++   G+EEKF+++  ++    T  +  P+ R  Y +L+L  + N      V E+F VEKG LQ+    + + A  +  F  ++   W  L  L+    +R+      +L+ L+ +  +   RA I FKAG +T+  IA A
Sbjct:  262 INWDLFLLMYNALPSSERKLLAECGLEEKFILEAIITRVDLT--AGTPRMR-LYIALMLQKIWNHEPMYTVAERFGVEKGWLQATLQSSISQAASIAKFSEKITTMWP-LRKLLPELVQRLSEAAQPELLPLMTVDGIKKARAAILFKAGYKTVGMIARA 417

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BLAST of DNA polymerase theta vs. Ensembl Celegans
Match: Y54E2A.4 (pep chromosome:WBcel235:II:14754622:14778149:1 gene:WBGene00013189.1 transcript:Y54E2A.4a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y54E2A.4)

HSP 1 Score: 61.2326 bits (147), Expect = 9.343e-9
Identity = 62/212 (29.25%), Postives = 109/212 (51.42%), Query Frame = 2

Query:  233 KNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXX----------XFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMS-PKGGLATVDIAVCTIEKANNLVNRLIDDGSL-EELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAE----LYVCD--YRPIPLQEMMKCDSKIYDCKD 814
            +NL+  APT AGKT ++ + +L  + E +             ++I P  +++ E    F K    +GLK+    GD    +  +A   + V T EK + +  +   D SL   + LL+IDE+H+L DE RG ++E L+      ++T+++ + +    +I+G+SATLPN   VA++L+      L+  D  +RP+PL +      K  + +D
Sbjct:  328 ENLLICAPTGAGKTNIAMLTILNTIHEHQNSRGDIMKDDFKIIYIAPMKALATEMTESFGKRLAPLGLKVKELTGDTQLSRNEVADTQMLVLTPEKWDVITRKSTSDNSLINVVRLLIIDEVHLLHDE-RGPVIETLV------ARTLRQVEMSQSGIRIVGLSATLPNFIDVARFLRVNPYKGLFFFDGRFRPVPLTQKFIGTRKAGNFRD 532

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BLAST of DNA polymerase theta vs. Ensembl Fly
Match: DNApol-theta (gene:FBgn0002905 transcript:FBtr0082662)

HSP 1 Score: 236.498 bits (602), Expect = 4.527e-62
Identity = 133/287 (46.34%), Postives = 191/287 (66.55%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYD-----CKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLA 976
            LP ++  +Y + G+  +F WQ EC+    +L    NLVYSAPTSAGKTLVSEI++LK VLE  KKVL ILP++SV +EKM Y Q L    G ++ GF G  +P GG  ++ +A+CTIEKAN++VN+L++ G LE + ++V+DE+H++ D+ RGYILELLL KILY S+       N  + Q+I MSATL N+ ++  WL AELY+ +YRP+ L+EM+K  + IYD      +D++    +       ++ D D +  LC+ET+LEG   +VFCP+K WCE ++  LA
Sbjct:  216 LPMSIQAEYKKKGVVDMFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKKVLLILPFISVVREKMFYMQDLLTPAGYRVEGFYGGYTPPGGFESLHVAICTIEKANSIVNKLMEQGKLETIGMVVVDEVHLISDKGRGYILELLLAKILYMSRR------NGLQIQVITMSATLENVQLLQSWLDAELYITNYRPVALKEMIKVGTVIYDHRLKLVRDVAKQKVLLKG----LENDSDDVALLCIETLLEGCSVIVFCPSKDWCENLAVQLA 492

HSP 2 Score: 207.608 bits (527), Expect = 3.655e-53
Identity = 171/632 (27.06%), Postives = 288/632 (45.57%), Query Frame = 2

Query: 3587 VYYLNL-LNPIGSRVNVSLKRRSEFLVDLLSLPHFLFVSFDWIFVLSLLERKLNQHFMKHDNLIDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIG----DRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKEV-KRTVDILKQMA---FIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNAS-HGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
             YY N+ ++   +   V    + + L +L++      V  D    L +L + + Q       L D  + +W+L  +   + FL++C  +          P    L ++   G       L  S+ I      A ++ V L I     +   ++   +  L K F  IEM I   + Q    G  F   + +++++ +R V ++K++    +   G  FN+ S + V+K+L +  +        G   T +    K+ +     +               YR L  L+ K++ PL E C+   I   +            ++TGR++ T PNLQ+V                       AKE  I    D V  + RS F  +     L++AD+ QLE+RIL+H S+D AL+     +   D+FI +A+ W K     +T   R   KQ+ YGI+YG+  + L+E ++  E +A  + ++F  A+ G+  +    ++  R  GF+ETITGRRRYL +I S+    ++ AERQA++STIQGSAADI K A++ ++  I    +  +    S++    +V+HLHDE+++EVP      +A +L   ME    L V L VK++ G  W E  +  V
Sbjct: 1499 AYYWNMQIDERAAYQGVPTPLKVQELCNLMARKDLTLVMHDGKEQLKMLRKAIPQLKRISAKLEDAKVANWLLQPDKTVN-FLNMCQTF---------APECTGLANLCGSGRGYSSYGLDTSSAILPRIRTAIESCVTLHILQGQTEN--LSRIGNGDLLKFFHDIEMPIQLTLCQMELVG--FPAQKQRLQQLYQRMVAVMKKVETKIYEQHGSRFNLGSSQAVAKVLGLHRKA------KGRVTTSRQVLEKLNSPISHLILG-------------YRKLSGLLAKSIQPLMECCQADRIHGQSIT---------YTATGRISMTEPNLQNV-----------------------AKEFSIQVGSDVVHISCRSPFMPTDESRCLLSADFCQLEMRILAHMSQDKALLEVM--KSSQDLFIAIAAHWNKIEESEVTQDLRNSTKQVCYGIVYGMGMRSLAESLNCSEQEARMISDQFHQAYKGIRDYTTRVVNFARSKGFVETITGRRRYLENINSDVEHLKNQAERQAVNSTIQGSAADIAKNAILKMEKNIERYREKLALGDNSVD----LVMHLHDELIFEVPTGKAKKIAKVLSLTMENCVKLSVPLKVKLRIGRSWGEFKEVSV 2059

HSP 3 Score: 149.443 bits (376), Expect = 1.800e-35
Identity = 92/272 (33.82%), Postives = 145/272 (53.31%), Query Frame = 2

Query:  917 GCLVFCPTKKWCETMSKNLAKELTPVYLSMNTA-------IDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKS-LKLEEAAMEMISESQMLLKRDLQLMGIEW 1708
            G ++F   +K     S  L  EL  VYL    +       IDW  + ++    S    +V  LVG+ + FL K ++ G+T   +     ++RFY +L L  LVNE     V  K+   +G LQSLQ  A+T+AG+VT FCN L WS L ++++ F+ R+ FG+  DL+DL+R+  ++  RAR  F AG+ ++  +AGA   E+  +L  S+ F SAK  DH    +    N  R     GK+ + + EAA  +I E++  ++ ++ L  I+W
Sbjct:  753 GLILFAELQK--SRRSFVLESELHAVYLVTPYSVCYQLQDIDWLLYVHMWEKLSSPMKKVGELVGVRDAFLYK-ALRGQTKLDYKQMQIHKRFYIALALEELVNETPINVVVHKYKCHRGMLQSLQQMASTFAGIVTAFCNSLQWSTLALIVSQFKDRLFFGIHRDLIDLMRIPDLSQKRARALFDAGITSLVELAGADPVELEKVLYNSISFDSAKQHDHENADEAAKRNVVRNFYITGKAGMTVSEAAKLLIGEARQFVQHEIGLGTIKW 1021

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BLAST of DNA polymerase theta vs. Ensembl Fly
Match: mus301 (gene:FBgn0002899 transcript:FBtr0076689)

HSP 1 Score: 155.606 bits (392), Expect = 1.066e-37
Identity = 102/283 (36.04%), Postives = 161/283 (56.89%), Query Frame = 2

Query:  167 GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDC-------KDLSTPIRM--FNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAK 979
            GI SL+ WQ EC+ L  +    KNL+Y+ PTS GKTLV+EI++L+ +L  ++ VLFILPYVS+ +EK   M  F      I  +     G   P+       + + +IEK   L++ LID     E+ L+V+DELH++G++ RG  LE  LTK+++ +  +          QI+GMSAT+ NL+ ++ +L A++Y   +RP+ L+E +KC   + +        +++  P R   +N    V + D D + GL  E   E H CLVFCP++K CE ++  L++
Sbjct:  260 GINSLYEWQDECLNLPAIRQ-RKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILPYVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDVQRPHEIGLVVVDELHLIGEKGRGATLEAFLTKVMFLNANI----------QIVGMSATIGNLSEISSFLNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPSRSVEYNYSEAVKRADPDHLAGLISECAPE-HCCLVFCPSRKNCENVALLLSR 530

HSP 2 Score: 52.7582 bits (125), Expect = 3.861e-6
Identity = 44/154 (28.57%), Postives = 65/154 (42.21%), Query Frame = 2

Query: 1169 RFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLG--WSH---LEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSA------------KVGDHIEEMKYN 1579
            R Y  LIL  ++N      V  K+NVE+G+LQ L  Q+   A  +   C  L   W +    E ++    R   F    +L  L+ L  +   RAR  + AG +TI  IA  +   +   L + +P + A            K  DH+EE   N
Sbjct:  892 RLYKVLILADILNLLPIPSVASKYNVERGTLQHLISQSTAAASAIVRLCEELEEFWCYKPLFERILHKMDRCGTF----ELEPLMELPAVKINRARQLYAAGFQTIGDIARVRPSHLVQSL-EHMPLRVATEIVSAAKIILMKKLDHLEEETEN 1040

[Close]

BLAST of DNA polymerase theta vs. Ensembl Fly
Match: l(3)72Ab (gene:FBgn0263599 transcript:FBtr0075527)

HSP 1 Score: 69.3218 bits (168), Expect = 4.559e-11
Identity = 62/220 (28.18%), Postives = 112/220 (50.91%), Query Frame = 2

Query:  167 GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXX----------XXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMS-PKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAE----LYVCD--YRPIPLQE 775
            G  +L   QS   K    LD  +N++  APT AGKT V+ + +++           +     K++++ P  S+ +E +  F +      L +    GD    +  +A   + VCT EK + +  +  +   +  + L++IDE+H+L DE RG +LE L+ + + + +T +E      E +++G+SATLPN   VA +L+ +    L+  D  YRP+ L++
Sbjct:  477 GFKTLNRIQSRLYK--AALDSDENMLLCAPTGAGKTNVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSLVQEMVGNFGRRLACYNLTVSELTGDHQLTREQIAATQVIVCTPEKWDIITRKGGERTFVSLVRLVIIDEIHLLHDE-RGPVLEALVARTIRNIETTQE------EVRLVGLSATLPNYQDVATFLRVKPDKGLFYFDNSYRPVSLEQ 687

[Close]

BLAST of DNA polymerase theta vs. Ensembl Fly
Match: obe (gene:FBgn0038344 transcript:FBtr0083147)

HSP 1 Score: 62.7734 bits (151), Expect = 4.049e-9
Identity = 72/271 (26.57%), Postives = 125/271 (46.13%), Query Frame = 2

Query:  227 GSKNLVYSAPTSAGKTLVSXXXXXXXXX---------XXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMS-PKGGLATVDIAVCTIEKANNLVNRLIDDGSLEEL-SLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAE----LYVCD--YRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELT 988
             ++N++  APT AGKT V+ + ++  +            + K+++I P  +++ E +  F K    + + +    GD+   K  +A   I V T EK + +  +   D +L  L  LL+IDE+H+L  E RG ++E L+      ++T++  + +    +I+G+SATLPN   VA +L+      L+  D  +RP+PL         I   K L     M  C               C+E + EGH  +VF   +      + N+ +EL 
Sbjct:  501 SNENMLVCAPTGAGKTNVAMLSIVHTIRCHLEQGVINRDEFKIVYIAPMKALAAEMVDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWDVVTRKGSGDVALISLVELLIIDEVHLLHGE-RGPVVEALV------ARTLRLVESSQSMIRIVGLSATLPNYIDVAHFLRVNPMKGLFYFDSRFRPVPLDTNF---VGIKSVKQLQQIADMDQC-----------CYQKCVEMVQEGHQIMVFVHARN-ATVRTANVIRELA 749

HSP 2 Score: 59.3066 bits (142), Expect = 4.841e-8
Identity = 60/205 (29.27%), Postives = 108/205 (52.68%), Query Frame = 2

Query:  236 NLVYSAPTSAGKTLVSXXXXXXXXXXXXX-XXXFILPYVSVSKEKMVYFQXXXXXXXX--XXXXXMGDMSPK-GGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWL---KAELY--VCDYRPIPLQEMMKCDSKIYDCKDLST 823
            N++  APT +GKT+V+EI + + + +  K KV++I P  ++ KE++  +++ F    L  K+    GD++P    +    + V T EK + +         ++ +SL+VIDE+H+LG E RG ++E+++++  + S          R  +I+G+S  L N   +A WL   K  LY      RP+PLQ  +      + C  ++T
Sbjct: 1354 NVLLGAPTGSGKTIVAEIAIFRALNQNPKCKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELTGDVTPDIQAIRESQLIVTTPEKWDGISRSWQTREYVQHVSLIVIDEIHLLG-EDRGPVIEVIVSRTNFISSHTG------RAIRIVGLSTALANAQDLANWLGINKMGLYNFKPSVRPVPLQVHINGFPGKHYCPRMAT 1551

[Close]

BLAST of DNA polymerase theta vs. Ensembl Zebrafish
Match: polq (polymerase (DNA directed), theta [Source:ZFIN;Acc:ZDB-GENE-040724-232])

HSP 1 Score: 282.722 bits (722), Expect = 5.040e-76
Identity = 149/285 (52.28%), Postives = 204/285 (71.58%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            LP+ V  +Y  LG+  +F WQ+EC+ L  VL+G +NLVYSAPTSAGKTLVSE+++LKRVLE ++K +FILP+VSV++EKM Y Q +F   G+++ G+MG  S  GG + +D+AVCTIEKAN LVNRLI++  L+ L  +V+DELHM+GD  RGY+LELLLTKI Y ++            QIIGMSATLPNL+++A+WL AELY  +YRP+PL E +K  + IYD       +R F  P+  IK D+D I+ LC ET+ +GH  L+FCP+K WCE ++ ++ +E 
Sbjct:   84 LPKPVLEKYQSLGVHRMFEWQAECLTLGKVLEG-QNLVYSAPTSAGKTLVSELLILKRVLETRQKAMFILPFVSVAREKMFYLQNVFQEAGIRVEGYMGSTSAAGGFSALDVAVCTIEKANGLVNRLIEEDKLDLLGTVVVDELHMVGDSGRGYLLELLLTKIRYIAQKTATRYSTSTGVQIIGMSATLPNLDLLARWLSAELYSTNYRPVPLMEWVKIGTNIYDGS--LNLVRQFT-PALPIKGDDDHIVSLCFETVQDGHSALLFCPSKNWCEKLADSIGREF 364

HSP 2 Score: 236.884 bits (603), Expect = 6.237e-62
Identity = 173/510 (33.92%), Postives = 266/510 (52.16%), Query Frame = 2

Query: 4061 FSFIEMNISYIIDQAPGFGVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGK------ITRKNST----SKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRD------------LFKNK------AKELGI-DKNEDSVI---CNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKN------------KSFHRKSLNQIPA--MVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            F  +EM   Y +      G+ FS+ E + ++  ++  +  L+  A+ ++G +F++ SP++V+++LF+E++ P  G  NG K       TR+       SK  ++TK  L  L  LHPLPG+ILE+R +   + K + PL    K     +     +I  I Q  ++TGR++ T PN+Q+VPK  +I    L+   +              ++K+       A  L + DK+ D  +    + R  F    G +++  DY QLELRIL+H SRD  L+   +     D+F  +A++W      S+ D  RQQAKQI YGIIYG+ A+ L EQM IEE+ A   I  F   + G+  F++ T+  C KNG+++T+ GR+R+LP I   N + +SHAERQA+++T+QGSAADIVK A + +   I   +                 HR     +     +L LHDE++YEV    +  +A I+K+ ME    L V L VKVK G  W  L D 
Sbjct: 1871 FKKVEMPTQYCLALLELNGIGFSIAECEAQKHVMQAKLSALESQAYQLAGHSFSLTSPEDVAEVLFLELKLPPNGDLNGLKNKKTLGYTRRAGARIKLSKQFSTTKDVLEKLKPLHPLPGVILEWRRITNALTKVVFPLQREKK---WHSHLKMDRIHPISQSHTATGRVSFTEPNIQNVPKDFEIQMPTLIEESQTSQNGGSKMWYISKIYKHNYINRQLAPLLKVSDKSPDKGMQFSVSMRHAFVPFSGGLILAVDYSQLELRILAHLSRDRRLL--HVLNSGADVFKSIAAEWKMVDPASVDDNMRQQAKQICYGIIYGMGAKSLGEQMGIEENDAACYIETFKSRYNGIQNFLRETVQKCGKNGYVKTLLGRKRFLPGIKDSNVYIKSHAERQAVNTTVQGSAADIVKLATINIQRRIEEAFPGVPTSHQHPSIRLGGRHRNQFRPLRGGYFILQLHDELIYEVAEEDVIQVAQIVKREMESVVKLYVKLRVKVKVGPSWGNLQDL 2375

HSP 3 Score: 192.2 bits (487), Expect = 2.754e-48
Identity = 105/253 (41.50%), Postives = 162/253 (64.03%), Query Frame = 2

Query:  980 ELTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGR----TSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNG-KSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTL 1723
            ++TPVY+   T IDW  F+ +      A  RV  +VGI+E FL + SV G+    T  +      ++RF+++L+L  LV+E     V +K+   +G LQSLQ  A+TYAGMVT+FCNRLGW +LE+L++ FQ R+ FGV  +L DLVR+SL+ A RAR  + +G  T++ +A A V E+   LRK++PF+S++      E++     S R +  +G K+L   EAA ++++E+Q+LL++DL L+G+EW+P  L
Sbjct:  640 QITPVYVDWTT-IDWYQFFCLWEQLPSAMKRVAEMVGIQEGFLAR-SVGGKLIAKTEKQRRQMAIHKRFFTTLVLLDLVSEEPLGAVAKKYGCSRGQLQSLQQSASTYAGMVTVFCNRLGWHNLELLLSQFQSRLSFGVQRELCDLVRISLLTAQRARTLYSSGFVTVAELARADVSEVEKALRKAIPFKSSRQAVDESEVEAQERKSMRCIWVSGKKALTEREAAQQIVAEAQLLLQKDLALLGVEWSPACL 890

[Close]

BLAST of DNA polymerase theta vs. Ensembl Zebrafish
Match: polq (polymerase (DNA directed), theta [Source:ZFIN;Acc:ZDB-GENE-040724-232])

HSP 1 Score: 281.182 bits (718), Expect = 1.538e-75
Identity = 153/288 (53.12%), Postives = 206/288 (71.53%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILY-HSKTMKENDPNYRET--QIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            LP+ V  +Y  LG+  +F WQ+EC+ L  VL+G +NLVYSAPTSAGKTLVSE+++LKRVLE ++K +FILP+VSV++EKM Y Q +F   G+++ G+MG  S  GG + +D+AVCTIEKAN LVNRLI++  L+ L  +V+DELHM+GD  RGY+LELLLTKI Y   KT   N      T  QIIGMSATLPNL+++A+WL AELY  +YRP+PL E +K  + IYD       +R F  P+  IK D+D I+ LC ET+ +GH  L+FCP+K WCE ++ ++ +E 
Sbjct:  283 LPKPVLEKYQSLGVHRMFEWQAECLTLGKVLEG-QNLVYSAPTSAGKTLVSELLILKRVLETRQKAMFILPFVSVAREKMFYLQNVFQEAGIRVEGYMGSTSAAGGFSALDVAVCTIEKANGLVNRLIEEDKLDLLGTVVVDELHMVGDSGRGYLLELLLTKIRYIAQKTATRNSGQSTSTGVQIIGMSATLPNLDLLARWLSAELYSTNYRPVPLMEWVKIGTNIYDGS--LNLVRQFT-PALPIKGDDDHIVSLCFETVQDGHSALLFCPSKNWCEKLADSIGREF 566

HSP 2 Score: 238.039 bits (606), Expect = 2.663e-62
Identity = 171/507 (33.73%), Postives = 264/507 (52.07%), Query Frame = 2

Query: 4061 FSFIEMNISYIIDQAPGFGVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGK------ITRKNST----SKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGI----------------DKNEDSVI---CNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKN------------KSFHRKSLNQIPA--MVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            F  +EM   Y +      G+ FS+ E + ++  ++  +  L+  A+ ++G +F++ SP++V+++LF+E++ P  G  NG K       TR+       SK  ++TK  L  L  LHPLPG+ILE+R +   + K + PL    K     +     +I  I Q  ++TGR++ T PN+Q+VPK  +I    L+  ++    +N   ++                  DK+ D  +    + R  F    G +++  DY QLELRIL+H SRD  L+   +     D+F  +A++W      S+ D  RQQAKQI YGIIYG+ A+ L EQM IEE+ A   I  F   + G+  F++ T+  C KNG+++T+ GR+R+LP I   N + +SHAERQA+++T+QGSAADIVK A + +   I   +                 HR     +     +L LHDE++YEV    +  +A I+K+ ME    L V L VKVK G  W  L D 
Sbjct: 2075 FKKVEMPTQYCLALLELNGIGFSIAECEAQKHVMQAKLSALESQAYQLAGHSFSLTSPEDVAEVLFLELKLPPNGDLNGLKNKKTLGYTRRAGARIKLSKQFSTTKDVLEKLKPLHPLPGVILEWRRITNALTKVVFPLQREKK---WHSHLKMDRIHPISQSHTATGRVSFTEPNIQNVPKDFEIQMPTLI--EESQTSQNGGSKMWCKRTKINRLLAPLLKVSDKSPDKGMQFSVSMRHAFVPFSGGLILAVDYSQLELRILAHLSRDRRLL--HVLNSGADVFKSIAAEWKMVDPASVDDNMRQQAKQICYGIIYGMGAKSLGEQMGIEENDAACYIETFKSRYNGIQNFLRETVQKCGKNGYVKTLLGRKRFLPGIKDSNVYIKSHAERQAVNTTVQGSAADIVKLATINIQRRIEEAFPGVPTSHQHPSIRLGGRHRNQFRPLRGGYFILQLHDELIYEVAEEDVIQVAQIVKREMESVVKLYVKLRVKVKVGPSWGNLQDL 2574

HSP 3 Score: 192.971 bits (489), Expect = 1.663e-48
Identity = 106/253 (41.90%), Postives = 162/253 (64.03%), Query Frame = 2

Query:  980 ELTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGR----TSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNG-KSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTL 1723
            ++TPVY+   T IDW  F+ +      A  RV  +VGI+E FL + SV G+    T  +      ++RF+++L+L  LV+E     V +K+   +G LQSLQ  A+TYAGMVT+FCNRLGW +LE+L++ FQ R+ FGV  +L DLVR+SL+ A RAR  + +G  T++ +A A V E+   LRK++PF+S++      E++     S R +  +G K+L   EAA ++++E+Q+LL++DL L+G+EWNP  L
Sbjct:  854 QITPVYVDWTT-IDWYQFFCLWEQLPSAMKRVAEMVGIQEGFLAR-SVGGKLIAKTEKQRRQMAIHKRFFTTLVLLDLVSEEPLGAVAKKYGCSRGQLQSLQQSASTYAGMVTVFCNRLGWHNLELLLSQFQSRLSFGVQRELCDLVRISLLTAQRARTLYSSGFVTVAELARADVTEVEKALRKAIPFKSSRQAVDESEVEAQERKSMRCIWVSGKKALTEREAAQQIVAEAQLLLQKDLALLGVEWNPACL 1104

[Close]

BLAST of DNA polymerase theta vs. Ensembl Zebrafish
Match: poln (polymerase (DNA directed) nu [Source:ZFIN;Acc:ZDB-GENE-100917-1])

HSP 1 Score: 185.652 bits (470), Expect = 9.239e-47
Identity = 131/429 (30.54%), Postives = 229/429 (53.38%), Query Frame = 2

Query: 4175 LKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPK-PIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCME-----KSYDLKVSLPVKV--KTGTVWSEL 5437
            L+Q A   +G+ F + S  ++  +LF ++R  +  +    K+ +     + T+ T   L  L  LHPLP +ILEYR +  +    ++ +    +K  I+ ST N       Q  + +GRL++  PN Q++PK P+QI+  + +H                 K  D V  + R+ F    G+  ++AD+ Q+ELR+L+H S DP L+  F   P+ D F  +A++W     + ++  DR+QAK+I Y ++YG   + LS  + +   +A +  + F+  +  V  FI+ TI  C+ +GF+ +I GRRR+LP I S +   R+ AERQA++  +QGSAAD+ K AM+ + + +++D           +Q   +V  +HDE+L+EV ++ +   A ++K+ ME     +  ++ +S+P+KV   TG  W  +
Sbjct:  743 LEQEAHQAAGQKFLVSSSAQLRLILFEKLR--LHELCENKKLPKTVKQQQSTSET--ALLQLQKLHPLPKVILEYRQIHKIKTTFVDGILSCTRKTFIS-STWN-------QTSTVSGRLSAKHPNFQALPKLPLQISKKQYIH----------------GKASDIVTVHPRAMFIPREGWTFLSADFCQVELRLLAHLSADPQLLRIF-QSPEADAFTMLAAQWCGVSEDRVSLEDREQAKRIVYSVVYGAGRERLSGILGVSAEEASRFQDSFLKTYREVPAFIQHTIQHCQSHGFVRSIMGRRRFLPHIHSADWSLRNQAERQAVNFVLQGSAADLAKLAMIRICSQVSSD-----------SQTARLVAQIHDELLFEVEISQLDQFAALVKKTMESLQHIEYLNVNLSVPLKVLLSTGRSWGSM 1131

[Close]

BLAST of DNA polymerase theta vs. Ensembl Zebrafish
Match: poln (polymerase (DNA directed) nu [Source:ZFIN;Acc:ZDB-GENE-100917-1])

HSP 1 Score: 184.882 bits (468), Expect = 1.511e-46
Identity = 131/429 (30.54%), Postives = 229/429 (53.38%), Query Frame = 2

Query: 4175 LKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPK-PIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCME-----KSYDLKVSLPVKV--KTGTVWSEL 5437
            L+Q A   +G+ F + S  ++  +LF ++R  +  +    K+ +     + T+ T   L  L  LHPLP +ILEYR +  +    ++ +    +K  I+ ST N       Q  + +GRL++  PN Q++PK P+QI+  + +H                 K  D V  + R+ F    G+  ++AD+ Q+ELR+L+H S DP L+  F   P+ D F  +A++W     + ++  DR+QAK+I Y ++YG   + LS  + +   +A +  + F+  +  V  FI+ TI  C+ +GF+ +I GRRR+LP I S +   R+ AERQA++  +QGSAAD+ K AM+ + + +++D           +Q   +V  +HDE+L+EV ++ +   A ++K+ ME     +  ++ +S+P+KV   TG  W  +
Sbjct:  744 LEQEAHQAAGQKFLVSSSAQLRLILFEKLR--LHELCENKKLPKTVKQQQSTSET--ALLQLQKLHPLPKIILEYRQIHKIKTTFVDGILSCTRKTFIS-STWN-------QTSTVSGRLSAKHPNFQALPKLPLQISKKQYIH----------------GKASDIVTVHPRAMFIPREGWTFLSADFCQVELRLLAHLSADPQLLRIF-QSPEADAFTMLAAQWKGVSEDRVSLEDREQAKRIVYSVVYGAGRERLSGILGVSAEEASRFQDSFLKTYREVPAFIQHTIQHCQSHGFVRSIMGRRRFLPHIHSADWSLRNQAERQAVNFVLQGSAADLAKLAMIRICSQVSSD-----------SQTARLVAQIHDELLFEVEISQLDQFAALVKKTMESLQHIEYLNVNLSVPLKVLLSTGRSWGSM 1132

[Close]

BLAST of DNA polymerase theta vs. Ensembl Zebrafish
Match: helq (helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-060503-421])

HSP 1 Score: 168.318 bits (425), Expect = 1.664e-41
Identity = 114/293 (38.91%), Postives = 164/293 (55.97%), Query Frame = 2

Query:  167 GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYD-------CKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTA 1015
            GI  L+ WQ  C+ L+ +    +NL+YS PTS GKTLV+EI++ K +L  KK  L ILPY+S+ +EK   +  F      +  +  G  G   P        + + TIEK ++LVN LI++  L+ + L+V+DELHMLGD  RG ILE+ L+KILY SK+          TQ+IGMSATL N+  +  +L+AE Y  ++RP+ L+E +K    IY+       C   S  +  F   SG+ K D D I+ L  E I +   CL+FC TKK CE ++  + K L   ++    A
Sbjct:  253 GIQDLYEWQKTCLSLDSI-QQRRNLIYSLPTSGGKTLVAEILIFKELLCRKKDALLILPYISLVQEKVRGLSSFGIELDFLVEEYAGSKGKFPPVKRRNKNSLYITTIEKGHSLVNSLIENDRLDNIGLVVVDELHMLGDGSRGAILEMTLSKILYMSKS----------TQVIGMSATLGNVKDLQSFLRAENYTNNFRPVELKEYVKIKDSIYEVDPKEEACFTFSRLLN-FKYSSGMQKMDPDHIIALATEVIPQ-QSCLIFCATKKNCENLAGMICKYLNKEFIKHKEA 532

HSP 2 Score: 81.6481 bits (200), Expect = 8.729e-15
Identity = 54/213 (25.35%), Postives = 105/213 (49.30%), Query Frame = 2

Query:  947 WCETMSKNLAKEL---------------TPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLG--WSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAK----VKEITNLLRK 1522
            +C+ + ++L+K L               TP  +      DW  ++    + S AE ++   VG+ E F+ +   +G++  +  D     R Y +L+L+ L+ E +   V+E+F + +G +Q+L   A+ +   V  F   L   W++ + L++   RR+ + V  +L+ L+ +S +   RA+  + AG +T+S +A A     V+ I NL +K
Sbjct:  763 YCDVLYRDLSKGLEGLLLNSFLHLVYLVTPYDMVHQCKPDWMIYFRQFTNLSAAEQKMATTVGVPESFVAR-KAAGQSVRKSVDVVVVNRLYLALVLFSLLKETNLWIVSERFQLTRGFVQTLLSSASAFGSSVLHFTEELEEFWAY-KALLSELTRRLTYCVQAELIPLMEVSGVLEHRAKQLYSAGYKTLSHLANADPQTLVQTIENLFKK 973

[Close]

BLAST of DNA polymerase theta vs. Ensembl Xenopus
Match: polq (polymerase (DNA directed), theta [Source:NCBI gene;Acc:733897])

HSP 1 Score: 276.174 bits (705), Expect = 9.047e-74
Identity = 151/294 (51.36%), Postives = 208/294 (70.75%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKT-----MKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVY 997
            LP+ V  +Y  LG++ +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE ++K LFILP+VSV+KEK  Y Q LF  +G+K+ G+MG  SP GG  ++D+AVCTIEKAN LVNRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTK+ Y ++        E      + QI+GMSATLPNL ++A WL AELY  D+RP+PL E +K    +YD   ++  +R F  P   +K D+D I+ L  ET+  GH  L+FCP+K WCE ++  +A+E   ++
Sbjct:  197 LPKTVLEKYGSLGVSQMFEWQAECLMLGQVLEG-KNLVYSAPTSAGKTLVAELLILKRVLETRRKALFILPFVSVAKEKTFYLQNLFQEVGVKVDGYMGSSSPAGGFCSLDVAVCTIEKANGLVNRLIEENKIDLLGMMVVDELHMLGDSHRGYLLELLLTKVRYVTQKGAVGRKAEGAGPANDVQIVGMSATLPNLGLLAAWLDAELYHTDFRPVPLLERVKIGRTVYDSNMVA--VREFE-PLLPVKGDDDHIVSLSYETVRGGHSILIFCPSKNWCEKLADTIAREFYNLF 486

HSP 2 Score: 248.825 bits (634), Expect = 1.947e-65
Identity = 177/520 (34.04%), Postives = 278/520 (53.46%), Query Frame = 2

Query: 4049 LYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG--IFNGGK----ITRKNSTS-------KITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDL--------FKNKAKELGID-------------KNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKN--KSF----------------HRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            L   F  +EM   Y +      G+ FS  E + ++  ++  ++ ++ +A+ ++G++F++ S  +++++LF+E++ P  G     G K     TR+ + S       K  ++ K  L  L +LHPLPGLILE++ +   + K + PL    ++ ++  +    +I  I Q  ++TGR++ T PN+Q+VPK  +I   +L+               ++N+ K+  ++             +   S   + R  F    G +++ ADY QLELRIL+H SRD  LI         D+F  +A++W     E++TD  RQQAKQI YGIIYG+ A+ L EQM IEES A   I+ F   + G+ +F+K T+  C ++GF++TI GRRRYLP I   NP+ +SHAERQA+++T+QGSAADIVKTA V +   +   + +  KS                 HR    +    +L LHDE+LYE        +A I+K+ ME +  L V L VKVK G  W +L DF
Sbjct: 2155 LQDAFHRVEMPTQYCLALLELNGMGFSTEECETQKHIMEAKLNEIEAVAYQLAGRSFSLTSHDDLAQVLFLELKLPPNGDPKAQGNKKTLGYTRRAAASGARVRLGKQFSTAKDVLEKLKALHPLPGLILEWKRITNALTKVVFPL---QREKLLNPNLGMERIYPISQTHTATGRVSFTEPNIQNVPKDFEIEMPRLVGESPPSQAPGPSAYPYRNRGKKPQVNTPGPKVPVEQIPAERGVSFFVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDRRLIQVL--NSGSDVFKSIAAEWKMIDPEAVTDTVRQQAKQICYGIIYGMGAKSLGEQMGIEESDAACYIDTFKSRYTGIQKFLKETVRSCTRDGFVQTILGRRRYLPAIKDSNPYAKSHAERQAVNTTVQGSAADIVKTATVNIQKRLEETFPSVPKSHEHPVQAGGTGRAERLRHRPPPTRGAFFILQLHDELLYEAAQEDAIQVAQIIKKEMENAMKLSVKLRVKVKMGPSWGDLQDF 2669

HSP 3 Score: 195.667 bits (496), Expect = 3.350e-49
Identity = 108/249 (43.37%), Postives = 155/249 (62.25%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTR----HSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVG-DHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNP 1714
            +TPVY    T IDW  F+ +      +  RV  LVGIEE FL + SV+G+   +    H     +RRF++SL+L  L++E S +++T+K+   +G LQSLQ  AATYAGMVT+F NRLGW ++E+L++ FQ R+ FGV  +L DLVR+ L+NA RAR  + AGL T++ +A A V ++   L+ ++PF+S +   D  EE       +  I  P  K L   EAA  ++ E++ LLK DL L+GIEWNP
Sbjct:  777 VTPVYEEWTT-IDWYQFFCLWEKLPTSMKRVAELVGIEEGFLAR-SVNGKIVAKNDRQHRQIAIHRRFFTSLVLLDLISEVSLKELTKKYGCSRGQLQSLQQSAATYAGMVTVFSNRLGWHNMELLLSQFQSRLTFGVQRELCDLVRVDLLNAQRARALYNAGLVTVAELARAHVIDVETALKNAVPFKSGRQAVDEEEEAAEERRAARCIWIPGRKGLTEREAAELIVGEARRLLKHDLALIGIEWNP 1023

[Close]

BLAST of DNA polymerase theta vs. Ensembl Xenopus
Match: polq (polymerase (DNA directed), theta [Source:NCBI gene;Acc:733897])

HSP 1 Score: 275.404 bits (703), Expect = 1.302e-73
Identity = 144/289 (49.83%), Postives = 195/289 (67.47%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMK----ENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            LP+ V  +Y  LG++ +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+  L           FILP+VSV+KEK  Y Q LF  +G+K+ G+MG  SP GG  ++D+AVCTIEKAN LVNRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTK+ Y ++         D    + QI+GMSATLPNL ++A WL AELY  D+RP+PL E +K    +YD   ++  +R F  P   +K D+D I+ L  ET+  GH  L+FCP+K WCE ++  +A+E 
Sbjct:   48 LPKTVLEKYGSLGVSQMFEWQAECLMLGQVLEG-KNLVYSAPTSAGKTLVAELKAL-----------FILPFVSVAKEKTFYLQNLFQEVGVKVDGYMGSSSPAGGFCSLDVAVCTIEKANGLVNRLIEENKIDLLGMMVVDELHMLGDSHRGYLLELLLTKVRYVTQKGAVGSHRTDSGPNDVQIVGMSATLPNLGLLAAWLDAELYHTDFRPVPLLERVKIGRTVYDSNMVA--VREFE-PLLPVKGDDDHIVSLSYETVRGGHSILIFCPSKNWCEKLADTIAREF 321

HSP 2 Score: 247.669 bits (631), Expect = 4.246e-65
Identity = 176/515 (34.17%), Postives = 274/515 (53.20%), Query Frame = 2

Query: 4049 LYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG--IFNGGK----ITRKNSTS-------KITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGID-------------KNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKN--KSF-------------------HRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            L   F  +EM   Y +      G+ FS  E + ++  ++  ++ ++ +A+ ++G++F++ S  +++++LF+E++ P  G     G K     TR+ + S       K  ++ K  L  L +LHPLPGLILE++ +   + K + PL    ++ ++  +    +I  I Q  ++TGR++ T PN+Q+VPK  +I   +L+            K+  ++             +   S   + R  F    G +++ ADY QLELRIL+H SRD  LI         D+F  +A++W     E++TD  RQQAKQI YGIIYG+ A+ L EQM IEES A   I+ F   + G+ +F+K T+  C ++GF++TI GRRRYLP I   NP+ +SHAERQA+++T+QGSAADIVKTA V +   +   + +  KS                    HR    +    +L LHDE+LYE        +A I+K+ ME +  L V L VKVK G  W +L DF
Sbjct: 1994 LQDAFHRVEMPTQYCLALLELNGMGFSTEECETQKHIMEAKLNEIEAVAYQLAGRSFSLTSHDDLAQVLFLELKLPPNGDPKAQGNKKTLGYTRRAAASGARVRLGKQFSTAKDVLEKLKALHPLPGLILEWKRITNALTKVVFPL---QREKLLNPNLGMERIYPISQTHTATGRVSFTEPNIQNVPKDFEIEMPRLVGESPPSQAPGPGKKPQVNTPGPKVPVEQIPAERGVSFFVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDRRLIQVL--NSGSDVFKSIAAEWKMIDPEAVTDTVRQQAKQICYGIIYGMGAKSLGEQMGIEESDAACYIDTFKSRYTGIQKFLKETVRSCTRDGFVQTILGRRRYLPAIKDSNPYAKSHAERQAVNTTVQGSAADIVKTATVNIQKRLEETFPSVPKSHEHPVQAGGTGWYEPYRRLRHRPPPTRGAFFILQLHDELLYEAAQEDAIQVAQIIKKEMENAMKLSVKLRVKVKMGPSWGDLQDF 2503

HSP 3 Score: 197.208 bits (500), Expect = 1.227e-49
Identity = 108/249 (43.37%), Postives = 155/249 (62.25%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTR----HSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVG-DHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNP 1714
            +TPVY    T IDW  F+ +      +  RV  LVGIEE FL + SV+G+   +    H     +RRF++SL+L  L++E S +++T+K+   +G LQSLQ  AATYAGMVT+F NRLGW ++E+L++ FQ R+ FGV  +L DLVR+ L+NA RAR  + AGL T++ +A A V ++   L+ ++PF+S +   D  EE       +  I  P  K L   EAA  ++ E++ LLK DL L+GIEWNP
Sbjct:  616 VTPVYEEWTT-IDWYQFFCLWEKLPTSMKRVAELVGIEEGFLAR-SVNGKIVAKNDRQHRQIAIHRRFFTSLVLLDLISEVSLKELTKKYGCSRGQLQSLQQSAATYAGMVTVFSNRLGWHNMELLLSQFQSRLTFGVQRELCDLVRVDLLNAQRARALYNAGLVTVAELARAHVIDVETALKNAVPFKSGRQAVDEEEEAAEERRAARCIWIPGRKGLTEREAAELIVGEARRLLKHDLALIGIEWNP 862

[Close]

BLAST of DNA polymerase theta vs. Ensembl Xenopus
Match: polq (polymerase (DNA directed), theta [Source:NCBI gene;Acc:733897])

HSP 1 Score: 249.21 bits (635), Expect = 1.286e-65
Identity = 136/293 (46.42%), Postives = 190/293 (64.85%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFI----LPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMK----ENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            LP+ V  +Y  LG++ +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE ++K  F      P+ S+    + + +             MG  SP GG  ++D+AVCTIEKAN LVNRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTK+ Y ++         D    + QI+GMSATLPNL ++A WL AELY  D+RP+PL E +K    +YD   ++  +R F  P   +K D+D I+ L  ET+  GH  L+FCP+K WCE ++  +A+E 
Sbjct:   18 LPKTVLEKYGSLGVSQMFEWQAECLMLGQVLEG-KNLVYSAPTSAGKTLVAELLILKRVLETRRKPQFAHLPQTPWNSLFIHLLTFLKVDGY---------MGSSSPAGGFCSLDVAVCTIEKANGLVNRLIEENKIDLLGMMVVDELHMLGDSHRGYLLELLLTKVRYVTQKGAVGSHRTDSGPNDVQIVGMSATLPNLGLLAAWLDAELYHTDFRPVPLLERVKIGRTVYDSNMVA--VREFE-PLLPVKGDDDHIVSLSYETVRGGHSILIFCPSKNWCEKLADTIAREF 297

HSP 2 Score: 247.669 bits (631), Expect = 4.212e-65
Identity = 176/515 (34.17%), Postives = 274/515 (53.20%), Query Frame = 2

Query: 4049 LYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG--IFNGGK----ITRKNSTS-------KITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGID-------------KNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKN--KSF-------------------HRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            L   F  +EM   Y +      G+ FS  E + ++  ++  ++ ++ +A+ ++G++F++ S  +++++LF+E++ P  G     G K     TR+ + S       K  ++ K  L  L +LHPLPGLILE++ +   + K + PL    ++ ++  +    +I  I Q  ++TGR++ T PN+Q+VPK  +I   +L+            K+  ++             +   S   + R  F    G +++ ADY QLELRIL+H SRD  LI         D+F  +A++W     E++TD  RQQAKQI YGIIYG+ A+ L EQM IEES A   I+ F   + G+ +F+K T+  C ++GF++TI GRRRYLP I   NP+ +SHAERQA+++T+QGSAADIVKTA V +   +   + +  KS                    HR    +    +L LHDE+LYE        +A I+K+ ME +  L V L VKVK G  W +L DF
Sbjct: 1970 LQDAFHRVEMPTQYCLALLELNGMGFSTEECETQKHIMEAKLNEIEAVAYQLAGRSFSLTSHDDLAQVLFLELKLPPNGDPKAQGNKKTLGYTRRAAASGARVRLGKQFSTAKDVLEKLKALHPLPGLILEWKRITNALTKVVFPL---QREKLLNPNLGMERIYPISQTHTATGRVSFTEPNIQNVPKDFEIEMPRLVGESPPSQAPGPGKKPQVNTPGPKVPVEQIPAERGVSFFVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDRRLIQVL--NSGSDVFKSIAAEWKMIDPEAVTDTVRQQAKQICYGIIYGMGAKSLGEQMGIEESDAACYIDTFKSRYTGIQKFLKETVRSCTRDGFVQTILGRRRYLPAIKDSNPYAKSHAERQAVNTTVQGSAADIVKTATVNIQKRLEETFPSVPKSHEHPVQAGGTGWYEPYRRLRHRPPPTRGAFFILQLHDELLYEAAQEDAIQVAQIIKKEMENAMKLSVKLRVKVKMGPSWGDLQDF 2479

HSP 3 Score: 197.208 bits (500), Expect = 1.150e-49
Identity = 108/249 (43.37%), Postives = 155/249 (62.25%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTR----HSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVG-DHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNP 1714
            +TPVY    T IDW  F+ +      +  RV  LVGIEE FL + SV+G+   +    H     +RRF++SL+L  L++E S +++T+K+   +G LQSLQ  AATYAGMVT+F NRLGW ++E+L++ FQ R+ FGV  +L DLVR+ L+NA RAR  + AGL T++ +A A V ++   L+ ++PF+S +   D  EE       +  I  P  K L   EAA  ++ E++ LLK DL L+GIEWNP
Sbjct:  592 VTPVYEEWTT-IDWYQFFCLWEKLPTSMKRVAELVGIEEGFLAR-SVNGKIVAKNDRQHRQIAIHRRFFTSLVLLDLISEVSLKELTKKYGCSRGQLQSLQQSAATYAGMVTVFSNRLGWHNMELLLSQFQSRLTFGVQRELCDLVRVDLLNAQRARALYNAGLVTVAELARAHVIDVETALKNAVPFKSGRQAVDEEEEAAEERRAARCIWIPGRKGLTEREAAELIVGEARRLLKHDLALIGIEWNP 838

[Close]

BLAST of DNA polymerase theta vs. Ensembl Xenopus
Match: polq (polymerase (DNA directed), theta [Source:NCBI gene;Acc:733897])

HSP 1 Score: 249.21 bits (635), Expect = 1.405e-65
Identity = 177/519 (34.10%), Postives = 278/519 (53.56%), Query Frame = 2

Query: 4049 LYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG--IFNGGK----ITRKNSTS-------KITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDL--------FKNKAKELGID-------------KNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKN--KSF---------------HRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            L   F  +EM   Y +      G+ FS  E + ++  ++  ++ ++ +A+ ++G++F++ S  +++++LF+E++ P  G     G K     TR+ + S       K  ++ K  L  L +LHPLPGLILE++ +   + K + PL    ++ ++  +    +I  I Q  ++TGR++ T PN+Q+VPK  +I   +L+               ++N+ K+  ++             +   S   + R  F    G +++ ADY QLELRIL+H SRD  LI         D+F  +A++W     E++TD  RQQAKQI YGIIYG+ A+ L EQM IEES A   I+ F   + G+ +F+K T+  C ++GF++TI GRRRYLP I   NP+ +SHAERQA+++T+QGSAADIVKTA V +   +   + +  KS                HR    +    +L LHDE+LYE        +A I+K+ ME +  L V L VKVK G  W +L DF
Sbjct: 1976 LQDAFHRVEMPTQYCLALLELNGMGFSTEECETQKHIMEAKLNEIEAVAYQLAGRSFSLTSHDDLAQVLFLELKLPPNGDPKAQGNKKTLGYTRRAAASGARVRLGKQFSTAKDVLEKLKALHPLPGLILEWKRITNALTKVVFPL---QREKLLNPNLGMERIYPISQTHTATGRVSFTEPNIQNVPKDFEIEMPRLVGESPPSQAPGPSAYPYRNRGKKPQVNTPGPKVPVEQIPAERGVSFFVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDRRLIQVL--NSGSDVFKSIAAEWKMIDPEAVTDTVRQQAKQICYGIIYGMGAKSLGEQMGIEESDAACYIDTFKSRYTGIQKFLKETVRSCTRDGFVQTILGRRRYLPAIKDSNPYAKSHAERQAVNTTVQGSAADIVKTATVNIQKRLEETFPSVPKSHDWHLSVPTGRAERLRHRPPPTRGAFFILQLHDELLYEAAQEDAIQVAQIIKKEMENAMKLSVKLRVKVKMGPSWGDLQDF 2489

HSP 2 Score: 245.358 bits (625), Expect = 1.991e-64
Identity = 138/296 (46.62%), Postives = 192/296 (64.86%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFI----LPYVSVSKEKMVY---FQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKT----MKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            LP+ V  +Y  LG++ +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE ++K  F      P+ S+    + +   F+      G      MG  SP GG  ++D+AVCTIEKAN LVNRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTK+ Y ++       E      + QI+GMSATLPNL ++A WL AELY  D+RP+PL E +K    +YD   ++  +R F  P   +K D+D I+ L  ET+  GH  L+FCP+K WCE ++  +A+E 
Sbjct:   18 LPKTVLEKYGSLGVSQMFEWQAECLMLGQVLEG-KNLVYSAPTSAGKTLVAELLILKRVLETRRKPQFAHLPQTPWNSLFIHLLTFCCLFEVGVKVDGY-----MGSSSPAGGFCSLDVAVCTIEKANGLVNRLIEENKIDLLGMMVVDELHMLGDSHRGYLLELLLTKVRYVTQKGAVGKAEGAGPANDVQIVGMSATLPNLGLLAAWLDAELYHTDFRPVPLLERVKIGRTVYDSNMVA--VREFE-PLLPVKGDDDHIVSLSYETVRGGHSILIFCPSKNWCEKLADTIAREF 304

HSP 3 Score: 197.208 bits (500), Expect = 1.105e-49
Identity = 108/249 (43.37%), Postives = 155/249 (62.25%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTR----HSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVG-DHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNP 1714
            +TPVY    T IDW  F+ +      +  RV  LVGIEE FL + SV+G+   +    H     +RRF++SL+L  L++E S +++T+K+   +G LQSLQ  AATYAGMVT+F NRLGW ++E+L++ FQ R+ FGV  +L DLVR+ L+NA RAR  + AGL T++ +A A V ++   L+ ++PF+S +   D  EE       +  I  P  K L   EAA  ++ E++ LLK DL L+GIEWNP
Sbjct:  598 VTPVYEEWTT-IDWYQFFCLWEKLPTSMKRVAELVGIEEGFLAR-SVNGKIVAKNDRQHRQIAIHRRFFTSLVLLDLISEVSLKELTKKYGCSRGQLQSLQQSAATYAGMVTVFSNRLGWHNMELLLSQFQSRLTFGVQRELCDLVRVDLLNAQRARALYNAGLVTVAELARAHVIDVETALKNAVPFKSGRQAVDEEEEAAEERRAARCIWIPGRKGLTEREAAELIVGEARRLLKHDLALIGIEWNP 844

[Close]

BLAST of DNA polymerase theta vs. Ensembl Xenopus
Match: polq (polymerase (DNA directed), theta [Source:NCBI gene;Acc:733897])

HSP 1 Score: 249.21 bits (635), Expect = 1.470e-65
Identity = 177/519 (34.10%), Postives = 278/519 (53.56%), Query Frame = 2

Query: 4049 LYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG--IFNGGK----ITRKNSTS-------KITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDL--------FKNKAKELGID-------------KNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKN--KSF---------------HRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            L   F  +EM   Y +      G+ FS  E + ++  ++  ++ ++ +A+ ++G++F++ S  +++++LF+E++ P  G     G K     TR+ + S       K  ++ K  L  L +LHPLPGLILE++ +   + K + PL    ++ ++  +    +I  I Q  ++TGR++ T PN+Q+VPK  +I   +L+               ++N+ K+  ++             +   S   + R  F    G +++ ADY QLELRIL+H SRD  LI         D+F  +A++W     E++TD  RQQAKQI YGIIYG+ A+ L EQM IEES A   I+ F   + G+ +F+K T+  C ++GF++TI GRRRYLP I   NP+ +SHAERQA+++T+QGSAADIVKTA V +   +   + +  KS                HR    +    +L LHDE+LYE        +A I+K+ ME +  L V L VKVK G  W +L DF
Sbjct: 2121 LQDAFHRVEMPTQYCLALLELNGMGFSTEECETQKHIMEAKLNEIEAVAYQLAGRSFSLTSHDDLAQVLFLELKLPPNGDPKAQGNKKTLGYTRRAAASGARVRLGKQFSTAKDVLEKLKALHPLPGLILEWKRITNALTKVVFPL---QREKLLNPNLGMERIYPISQTHTATGRVSFTEPNIQNVPKDFEIEMPRLVGESPPSQAPGPSAYPYRNRGKKPQVNTPGPKVPVEQIPAERGVSFFVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDRRLIQVL--NSGSDVFKSIAAEWKMIDPEAVTDTVRQQAKQICYGIIYGMGAKSLGEQMGIEESDAACYIDTFKSRYTGIQKFLKETVRSCTRDGFVQTILGRRRYLPAIKDSNPYAKSHAERQAVNTTVQGSAADIVKTATVNIQKRLEETFPSVPKSHDWHLSVPTGRAERLRHRPPPTRGAFFILQLHDELLYEAAQEDAIQVAQIIKKEMENAMKLSVKLRVKVKMGPSWGDLQDF 2634

HSP 2 Score: 245.743 bits (626), Expect = 1.962e-64
Identity = 138/296 (46.62%), Postives = 192/296 (64.86%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFI----LPYVSVSKEKMVY---FQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKT----MKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            LP+ V  +Y  LG++ +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE ++K  F      P+ S+    + +   F+      G      MG  SP GG  ++D+AVCTIEKAN LVNRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTK+ Y ++       E      + QI+GMSATLPNL ++A WL AELY  D+RP+PL E +K    +YD   ++  +R F  P   +K D+D I+ L  ET+  GH  L+FCP+K WCE ++  +A+E 
Sbjct:  163 LPKTVLEKYGSLGVSQMFEWQAECLMLGQVLEG-KNLVYSAPTSAGKTLVAELLILKRVLETRRKPQFAHLPQTPWNSLFIHLLTFCCLFEVGVKVDGY-----MGSSSPAGGFCSLDVAVCTIEKANGLVNRLIEENKIDLLGMMVVDELHMLGDSHRGYLLELLLTKVRYVTQKGAVGKAEGAGPANDVQIVGMSATLPNLGLLAAWLDAELYHTDFRPVPLLERVKIGRTVYDSNMVA--VREFE-PLLPVKGDDDHIVSLSYETVRGGHSILIFCPSKNWCEKLADTIAREF 449

HSP 3 Score: 196.823 bits (499), Expect = 1.419e-49
Identity = 108/249 (43.37%), Postives = 155/249 (62.25%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTR----HSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVG-DHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNP 1714
            +TPVY    T IDW  F+ +      +  RV  LVGIEE FL + SV+G+   +    H     +RRF++SL+L  L++E S +++T+K+   +G LQSLQ  AATYAGMVT+F NRLGW ++E+L++ FQ R+ FGV  +L DLVR+ L+NA RAR  + AGL T++ +A A V ++   L+ ++PF+S +   D  EE       +  I  P  K L   EAA  ++ E++ LLK DL L+GIEWNP
Sbjct:  743 VTPVYEEWTT-IDWYQFFCLWEKLPTSMKRVAELVGIEEGFLAR-SVNGKIVAKNDRQHRQIAIHRRFFTSLVLLDLISEVSLKELTKKYGCSRGQLQSLQQSAATYAGMVTVFSNRLGWHNMELLLSQFQSRLTFGVQRELCDLVRVDLLNAQRARALYNAGLVTVAELARAHVIDVETALKNAVPFKSGRQAVDEEEEAAEERRAARCIWIPGRKGLTEREAAELIVGEARRLLKHDLALIGIEWNP 989

[Close]

BLAST of DNA polymerase theta vs. Ensembl Mouse
Match: Polq (polymerase (DNA directed), theta [Source:MGI Symbol;Acc:MGI:2155399])

HSP 1 Score: 293.893 bits (751), Expect = 2.277e-79
Identity = 204/570 (35.79%), Postives = 317/570 (55.61%), Query Frame = 2

Query:  122 NVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEEL--SLLVIDELHMLGDEHRG-YILELLLTKILYHSKTMKENDPNYRETQII------GMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKE---------------------------LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFL---IKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNP 1714
            N  LP+ V  +Y+  G+  +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE +KK LFILP+VSV+KEK  Y Q LF  +GLK+ G+MG  SP G  +++DIAVCTIE+AN LVNRLI++  ++ L  S+LV        ++ +G  +L+  L  +  HS   ++ +      + I      G+++T  ++   A         C +    +QE  +   +  D   L     +  C + +++ +  Q+         +G G  V+ PT     T+S +L+                             +TPV+     +IDW  F+ +      +  RV  LVG+EE FL   +K  V  RT  +H     ++RF++SL+L  L++E   + + +K+   +G +QSLQ  AA YAGM+T+F NRLGW ++E+L++ FQ+R+ FG+  +L DL+R+SL+NA RAR  + +G  T++ +A A   E+   L+ SLPF+SA+     EE       S R +   GK L   EAA  ++ E++M+L++DL  MG+ W+P
Sbjct:   72 NWGLPKAVLEKYHSFGVRKMFEWQAECLLLGHVLEG-KNLVYSAPTSAGKTLVAELLILKRVLETRKKALFILPFVSVAKEKKCYLQSLFQEVGLKVDGYMGSTSPTGQFSSLDIAVCTIERANGLVNRLIEENKMDLLGESILVCKN----SEKSKGIALLQGSLEPV--HSCLQRQGEVTASMIRAILEIIVGGVASTSQDMQTYA--------ACTFLAAAIQEGKQGMQRNQDDAQLGA---IDACVTWLLENEFIQVA-----EPGDGTGGKVYHPTHLGSATLSSSLSPTDTLDIFADLQRAMKGFVLENDLHIVYLVTPVFEDW-ISIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEIPLKDINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLIRVSLLNAQRARFLYASGFLTVADLARADSAEVEVALKNSLPFKSARKAVDEEEEAAEERRSMRTIWVTGKGLSAREAAALIVEEAKMILQQDLIEMGVRWDP 617

HSP 2 Score: 246.514 bits (628), Expect = 6.033e-65
Identity = 183/541 (33.83%), Postives = 273/541 (50.46%), Query Frame = 2

Query: 4049 LYKHFSFIEMNISYIID--QAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG-------------IFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLV---------EKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKL--------------------------LHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAIT---ADYKNKSFHRKSLNQ------IPA--------------MVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            L+  F  +EM   Y +   +  G G + +  ESQ   ++  +D ++  A+ ++G +F+  S  +++++LF+E++ P  G                G +  R+    +  +++K  LN L  LHPLPGLILE+R +   +         EK LNPL                +I  + Q  ++TGR+  T PN+Q+VP+  +I    L                          LH   R   + KA + G+         + R  F    G +++ ADY QLELRIL+H SRD  LI         D+F  +A++W     +++ D  RQ AKQI YGIIYG+ A+ L EQM I+E+ A   I+ F   + G++ F++ T+  CRKNGF+ETI GRRRYLP I  +NP+ ++HAERQAI++T+QGSAADIVK A V +   +    + +K+   HR+S+ Q      +P                +L LHDE+LYEV    +  +A I+K  ME +  L V L VKVK G  W EL DF V
Sbjct: 1745 LHDIFCKVEMPSQYCLALLELNGIGFSTAECESQKHVMQAKLDAIETQAYQLAGHSFSFTSADDIAQVLFLELKLPPNGEMKTQGSKKTLGSTRRGNESGRRMRLGRQFSTSKDILNKLKGLHPLPGLILEWRRISNAITKVVFPLQREKHLNPLLRM------------ERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVRESPPSQAPKGRFPMAIGQDKKVYGLHPGHRTQMEEKASDRGV-----PFSVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDCRLIQVL--NTGADVFRSIAAEWKMIEPDAVGDDLRQHAKQICYGIIYGMGAKSLGEQMGIKENDAASYIDSFKSRYKGINHFMRDTVKNCRKNGFVETILGRRRYLPGIKDDNPYHKAHAERQAINTTVQGSAADIVKIATVNIQKQLETFRSTFKSHG-HRESMLQNDRTGLLPKRKLKGMFCPMRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMECAIKLSVKLKVKVKIGASWGELKDFDV 2265

[Close]

BLAST of DNA polymerase theta vs. Ensembl Mouse
Match: Polq (polymerase (DNA directed), theta [Source:MGI Symbol;Acc:MGI:2155399])

HSP 1 Score: 278.87 bits (712), Expect = 9.599e-75
Identity = 158/293 (53.92%), Postives = 207/293 (70.65%), Query Frame = 2

Query:  122 NVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRET-----QIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            N  LP+ V  +Y+  G+  +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE +KK LFILP+VSV+KEK  Y Q LF  +GLK+ G+MG  SP G  +++DIAVCTIE+AN LVNRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTKI Y ++    +      T     QI+GMSATLPNL +VA WL AELY  D+RP+PL E +K  + IYD       +R F  P   +K DED I+ LC ETI + H  L+FCP+KKWCE ++  +A+E 
Sbjct:   72 NWGLPKAVLEKYHSFGVRKMFEWQAECLLLGHVLEG-KNLVYSAPTSAGKTLVAELLILKRVLETRKKALFILPFVSVAKEKKCYLQSLFQEVGLKVDGYMGSTSPTGQFSSLDIAVCTIERANGLVNRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYVTRKSASHQAESASTLSNAVQIVGMSATLPNLQLVASWLNAELYHTDFRPVPLLESIKIGNSIYDSS--MKLVREFQ-PLLQVKGDEDHIVSLCYETIQDNHSVLIFCPSKKWCEKVADIIAREF 360

HSP 2 Score: 247.284 bits (630), Expect = 4.493e-65
Identity = 183/541 (33.83%), Postives = 273/541 (50.46%), Query Frame = 2

Query: 4049 LYKHFSFIEMNISYIID--QAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG-------------IFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLV---------EKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKL--------------------------LHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAIT---ADYKNKSFHRKSLNQ------IPA--------------MVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            L+  F  +EM   Y +   +  G G + +  ESQ   ++  +D ++  A+ ++G +F+  S  +++++LF+E++ P  G                G +  R+    +  +++K  LN L  LHPLPGLILE+R +   +         EK LNPL                +I  + Q  ++TGR+  T PN+Q+VP+  +I    L                          LH   R   + KA + G+         + R  F    G +++ ADY QLELRIL+H SRD  LI         D+F  +A++W     +++ D  RQ AKQI YGIIYG+ A+ L EQM I+E+ A   I+ F   + G++ F++ T+  CRKNGF+ETI GRRRYLP I  +NP+ ++HAERQAI++T+QGSAADIVK A V +   +    + +K+   HR+S+ Q      +P                +L LHDE+LYEV    +  +A I+K  ME +  L V L VKVK G  W EL DF V
Sbjct: 2024 LHDIFCKVEMPSQYCLALLELNGIGFSTAECESQKHVMQAKLDAIETQAYQLAGHSFSFTSADDIAQVLFLELKLPPNGEMKTQGSKKTLGSTRRGNESGRRMRLGRQFSTSKDILNKLKGLHPLPGLILEWRRISNAITKVVFPLQREKHLNPLLRM------------ERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVRESPPSQAPKGRFPMAIGQDKKVYGLHPGHRTQMEEKASDRGV-----PFSVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDCRLIQVL--NTGADVFRSIAAEWKMIEPDAVGDDLRQHAKQICYGIIYGMGAKSLGEQMGIKENDAASYIDSFKSRYKGINHFMRDTVKNCRKNGFVETILGRRRYLPGIKDDNPYHKAHAERQAINTTVQGSAADIVKIATVNIQKQLETFRSTFKSHG-HRESMLQNDRTGLLPKRKLKGMFCPMRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMECAIKLSVKLKVKVKIGASWGELKDFDV 2544

HSP 3 Score: 193.356 bits (490), Expect = 1.179e-48
Identity = 96/247 (38.87%), Postives = 151/247 (61.13%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFL---IKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNP 1714
            +TPV+     +IDW  F+ +      +  RV  LVG+EE FL   +K  V  RT  +H     ++RF++SL+L  L++E   + + +K+   +G +QSLQ  AA YAGM+T+F NRLGW ++E+L++ FQ+R+ FG+  +L DL+R+SL+NA RAR  + +G  T++ +A A   E+   L+ SLPF+SA+     EE       S R +   GK L   EAA  ++ E++M+L++DL  MG+ W+P
Sbjct:  651 VTPVFEDW-ISIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEIPLKDINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLIRVSLLNAQRARFLYASGFLTVADLARADSAEVEVALKNSLPFKSARKAVDEEEEAAEERRSMRTIWVTGKGLSAREAAALIVEEAKMILQQDLIEMGVRWDP 896

[Close]

BLAST of DNA polymerase theta vs. Ensembl Mouse
Match: Poln (DNA polymerase N [Source:MGI Symbol;Acc:MGI:2675617])

HSP 1 Score: 177.948 bits (450), Expect = 9.515e-45
Identity = 131/430 (30.47%), Postives = 222/430 (51.63%), Query Frame = 2

Query: 4175 LKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPK-PIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCME-----KSYDLKVSLPVKV--KTGTVWSELN 5440
            L+Q A  V+G+ F I S  ++ ++LF +++     + +  K   +       ++++  LN L  LHPLP LILEYR +  +    ++ L    KK  I+ ST N       Q  + TGRL++  PN+Q + K PI+I+        K   FK K         E++V  + R+ F +S G   + AD+ Q+ELRIL+H S DP L+  F      D+F  + S+W   P+E +T +DR+Q K++ Y ++YG   + L+  + +   +A   +  F+  +  +  F ++ I  C   G++ +I GRRR LP I +++   R+ AERQA++  +QGSAAD+ K AM+ +  A+            S      +V  +HDE+L+EV    +   A ++++ ME     ++ +L++ +P+KV    G  W  L 
Sbjct:  465 LEQEAHFVAGEQFLIMSNNQLREILFGKLKL---HLLSQRKHLPRTGLQNQLSTSEAMLNSLQDLHPLPKLILEYRQVHKIKSTFIDGLLAYMKKGSIS-STWN-------QTGTVTGRLSAKHPNIQGISKHPIKIS--------KPWNFKGK--------EEETVTISPRTLFVSSEGHTFLAADFSQIELRILAHLSGDPELLKLFQESERDDVFSTLTSQWKDIPIERVTHMDREQTKKVVYSVVYGAGKERLAACLGVTVLEATHFLERFLQKYKKIKDFAQTVIGQCHSAGYVTSILGRRRPLPRICAQDQQLRAQAERQAVNFVVQGSAADLCKLAMIRISTAVAT----------SPTLTARLVAQIHDELLFEVEDTQVPEFAALVRRIMESLQQVQTLELQLQVPLKVNLSVGRSWGHLT 857

[Close]

BLAST of DNA polymerase theta vs. Ensembl Mouse
Match: Helq (helicase, POLQ-like [Source:MGI Symbol;Acc:MGI:2176740])

HSP 1 Score: 176.792 bits (447), Expect = 5.278e-44
Identity = 123/300 (41.00%), Postives = 174/300 (58.00%), Query Frame = 2

Query:  131 LPQNVFNQYNEL-GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYD----CKDLSTPIRM--FNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYL 1000
            LP  V + Y +L GI  L+ WQ  C+ L  V +  KNL+YS PTS GKTLV+EI++L+ +L  +K VL ILPYV++ +EK   +  F    G    +  G  G   P        + + TIEKA++LVN LI+   L  L L+V+DELHM+G+  RG ILE+ L K+LY SKT          TQIIGMSATL N+  +  +LKAE Y   +RP+ L+E +K +  IY+      D  T  R+  +     + K D D+++ L  E ++  + CLVFCP+KK CE +++ L K L+  YL
Sbjct:  278 LPSKVRDLYVQLKGIKKLYDWQHTCLTLRSVQE-RKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKISSLSSFGIELGFFVEEYAGSKGRFPPIKRREKKSLYIATIEKAHSLVNALIETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKVLYTSKT----------TQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDSQAADGMTFSRLLSYKYSEALKKMDPDRLVALVTE-VIPNYSCLVFCPSKKNCENVAEMLCKFLSKDYL 565

HSP 2 Score: 90.1225 bits (222), Expect = 1.971e-17
Identity = 59/213 (27.70%), Postives = 104/213 (48.83%), Query Frame = 2

Query:  947 WCETMSKNLAKEL---------------TPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLG--WSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAK----VKEITNLLRK 1522
            +C+T+ ++L K L               TP  L+  +  DW  ++      S  E  V  L+G+ E F+ K   +G+   +  D     R Y S +LY L+ E +   V+EKFN+ +G +Q+L M AA+++  V  FC  L   W + + L+    +++ + V  +L+ L+ ++ +   RA+  + AG  +I  +A A     VK I +L R+
Sbjct:  804 YCDTLYRDLKKGLEGLVLESLLHLIYLTTPYDLAAQSEPDWMVYFKQFGQLSPTEQNVAALLGVSESFIGK-KAAGQAVRKKVDKNVVNRLYLSFVLYSLLKETNVWSVSEKFNLPRGYIQNLLMGAASFSSCVLHFCEELEEFWVY-KALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYNAGYRSIMHLANANPEVLVKTIDHLSRR 1014

[Close]

BLAST of DNA polymerase theta vs. Ensembl Mouse
Match: Helq (helicase, POLQ-like [Source:MGI Symbol;Acc:MGI:2176740])

HSP 1 Score: 174.866 bits (442), Expect = 1.251e-43
Identity = 123/301 (40.86%), Postives = 175/301 (58.14%), Query Frame = 2

Query:  131 LPQNVFNQYNEL-GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYD----CKDLSTPIRM--FNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLS 1003
            LP  V + Y +L GI  L+ WQ  C+ L  V +  KNL+YS PTS GKTLV+EI++L+ +L  +K VL ILPYV++ +EK   +  F    G    +  G  G   P        + + TIEKA++LVN LI+   L  L L+V+DELHM+G+  RG ILE+ L K+LY SKT          TQIIGMSATL N+  +  +LKAE Y   +RP+ L+E +K +  IY+      D  T  R+  +     + K D D+++ L  E ++  + CLVFCP+KK CE +++ L K L+  YL+
Sbjct:  277 LPSKVRDLYVQLKGIKKLYDWQHTCLTLRSVQE-RKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKISSLSSFGIELGFFVEEYAGSKGRFPPIKRREKKSLYIATIEKAHSLVNALIETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKVLYTSKT----------TQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDSQAADGMTFSRLLSYKYSEALKKMDPDRLVALVTE-VIPNYSCLVFCPSKKNCENVAEMLCKFLSKDYLN 565

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BLAST of DNA polymerase theta vs. UniProt/SwissProt
Match: sp|Q8CGS6|DPOLQ_MOUSE (DNA polymerase theta OS=Mus musculus OX=10090 GN=Polq PE=1 SV=2)

HSP 1 Score: 278.87 bits (712), Expect = 6.715e-74
Identity = 158/293 (53.92%), Postives = 207/293 (70.65%), Query Frame = 2

Query:  122 NVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRET-----QIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            N  LP+ V  +Y+  G+  +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE +KK LFILP+VSV+KEK  Y Q LF  +GLK+ G+MG  SP G  +++DIAVCTIE+AN LVNRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTKI Y ++    +      T     QI+GMSATLPNL +VA WL AELY  D+RP+PL E +K  + IYD       +R F  P   +K DED I+ LC ETI + H  L+FCP+KKWCE ++  +A+E 
Sbjct:   72 NWGLPKAVLEKYHSFGVRKMFEWQAECLLLGHVLEG-KNLVYSAPTSAGKTLVAELLILKRVLETRKKALFILPFVSVAKEKKCYLQSLFQEVGLKVDGYMGSTSPTGQFSSLDIAVCTIERANGLVNRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYVTRKSASHQAESASTLSNAVQIVGMSATLPNLQLVASWLNAELYHTDFRPVPLLESIKIGNSIYDSS--MKLVREFQ-PLLQVKGDEDHIVSLCYETIQDNHSVLIFCPSKKWCEKVADIIAREF 360

HSP 2 Score: 247.284 bits (630), Expect = 3.143e-64
Identity = 183/541 (33.83%), Postives = 273/541 (50.46%), Query Frame = 2

Query: 4049 LYKHFSFIEMNISYIID--QAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG-------------IFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLV---------EKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKL--------------------------LHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAIT---ADYKNKSFHRKSLNQ------IPA--------------MVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            L+  F  +EM   Y +   +  G G + +  ESQ   ++  +D ++  A+ ++G +F+  S  +++++LF+E++ P  G                G +  R+    +  +++K  LN L  LHPLPGLILE+R +   +         EK LNPL                +I  + Q  ++TGR+  T PN+Q+VP+  +I    L                          LH   R   + KA + G+         + R  F    G +++ ADY QLELRIL+H SRD  LI         D+F  +A++W     +++ D  RQ AKQI YGIIYG+ A+ L EQM I+E+ A   I+ F   + G++ F++ T+  CRKNGF+ETI GRRRYLP I  +NP+ ++HAERQAI++T+QGSAADIVK A V +   +    + +K+   HR+S+ Q      +P                +L LHDE+LYEV    +  +A I+K  ME +  L V L VKVK G  W EL DF V
Sbjct: 2024 LHDIFCKVEMPSQYCLALLELNGIGFSTAECESQKHVMQAKLDAIETQAYQLAGHSFSFTSADDIAQVLFLELKLPPNGEMKTQGSKKTLGSTRRGNESGRRMRLGRQFSTSKDILNKLKGLHPLPGLILEWRRISNAITKVVFPLQREKHLNPLLRM------------ERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVRESPPSQAPKGRFPMAIGQDKKVYGLHPGHRTQMEEKASDRGV-----PFSVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDCRLIQVL--NTGADVFRSIAAEWKMIEPDAVGDDLRQHAKQICYGIIYGMGAKSLGEQMGIKENDAASYIDSFKSRYKGINHFMRDTVKNCRKNGFVETILGRRRYLPGIKDDNPYHKAHAERQAINTTVQGSAADIVKIATVNIQKQLETFRSTFKSHG-HRESMLQNDRTGLLPKRKLKGMFCPMRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMECAIKLSVKLKVKVKIGASWGELKDFDV 2544

HSP 3 Score: 193.356 bits (490), Expect = 8.248e-48
Identity = 96/247 (38.87%), Postives = 151/247 (61.13%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFL---IKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNP 1714
            +TPV+     +IDW  F+ +      +  RV  LVG+EE FL   +K  V  RT  +H     ++RF++SL+L  L++E   + + +K+   +G +QSLQ  AA YAGM+T+F NRLGW ++E+L++ FQ+R+ FG+  +L DL+R+SL+NA RAR  + +G  T++ +A A   E+   L+ SLPF+SA+     EE       S R +   GK L   EAA  ++ E++M+L++DL  MG+ W+P
Sbjct:  651 VTPVFEDW-ISIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEIPLKDINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLIRVSLLNAQRARFLYASGFLTVADLARADSAEVEVALKNSLPFKSARKAVDEEEEAAEERRSMRTIWVTGKGLSAREAAALIVEEAKMILQQDLIEMGVRWDP 896

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BLAST of DNA polymerase theta vs. UniProt/SwissProt
Match: sp|O75417|DPOLQ_HUMAN (DNA polymerase theta OS=Homo sapiens OX=9606 GN=POLQ PE=1 SV=2)

HSP 1 Score: 273.478 bits (698), Expect = 2.892e-72
Identity = 153/293 (52.22%), Postives = 207/293 (70.65%), Query Frame = 2

Query:  122 NVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRET-----QIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL 985
            N  LP+ V  +Y+  G+  +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE++KK LFILP+VSV+KEK  Y Q LF  +G+K+ G+MG  SP    +++DIAVCTIE+AN L+NRLI++  ++ L ++V+DELHMLGD HRGY+LELLLTKI Y ++       +   +     QI+GMSATLPNL +VA WL AELY  D+RP+PL E +K  + IYD       +R F  P   +K DED ++ LC ETI + H  L+FCP+KKWCE ++  +A+E 
Sbjct:   73 NWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEG-KNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSS--MKLVREFE-PMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREF 361

HSP 2 Score: 235.343 bits (599), Expect = 1.234e-60
Identity = 177/532 (33.27%), Postives = 264/532 (49.62%), Query Frame = 2

Query: 4061 FSFIEMNISYIIDQAPGFGVNFSVME--SQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPV-----------------QGIFNGGKI--TRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPL-FEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPK--------------PIQINWFKLLHLDKRDLFKN---------KAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAIT---ADYKNKSFHRKSLNQ-----------IPAM---------VLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            F  +EM   Y +      G+ FS  E  SQ   ++  +D ++  A+ ++G +F+  S  +++++LF+E++ P                  +GI NG K+   R+ STSK   +  K L+ L  L        E+R +   + K + PL  E C    +      P    + Q  ++TGR+  T PN+Q+VP+              P Q     LL + +    K          + +E   D+     I + R  F    G  ++ ADY QLELRIL+H S D  LI         D+F  +A++W     ES+ D  RQQAKQI YGIIYG+ A+ L EQM I+E+ A   I+ F   + G++QF+  T+  C+++GF++TI GRRRYLP I   NP+ ++HAERQAI++ +QGSAADIVK A V +   +    + +K+   HR+ + Q           +  M         +L LHDE+LYEV    +  +A I+K  ME +  L V L VKVK G  W EL DF V
Sbjct: 2073 FRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLIL------EWRRITNAITKVVFPLQREKCLNPFLGMERIYP----VSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSI-SMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVL--NTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHG-HREGMLQSDQTGLSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV 2590

HSP 3 Score: 194.897 bits (494), Expect = 3.128e-48
Identity = 96/252 (38.10%), Postives = 158/252 (62.70%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFL---IKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNG-KSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLV 1726
            +TP++    T IDW  F+ +      +  RV  LVG+EE FL   +K  V  RT  +H     ++RF++SL+L  L++E   +++ +K+   +G +QSLQ  AA YAGM+T+F NRLGW ++E+L++ FQ+R+ FG+  +L DLVR+SL+NA RAR+ + +G  T++ +A A + E+  +L+ ++PF+SA+     EE       + R +   G K L   EAA  ++ E++M+L++DL  MG++WNP  L+
Sbjct:  654 VTPMFEDW-TTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALL 904

[Close]

BLAST of DNA polymerase theta vs. UniProt/SwissProt
Match: sp|O18475|DPOLQ_DROME (DNA polymerase theta OS=Drosophila melanogaster OX=7227 GN=DNApol-theta PE=1 SV=1)

HSP 1 Score: 236.498 bits (602), Expect = 4.538e-61
Identity = 133/287 (46.34%), Postives = 191/287 (66.55%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYD-----CKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLA 976
            LP ++  +Y + G+  +F WQ EC+    +L    NLVYSAPTSAGKTLVSEI++LK VLE  KKVL ILP++SV +EKM Y Q L    G ++ GF G  +P GG  ++ +A+CTIEKAN++VN+L++ G LE + ++V+DE+H++ D+ RGYILELLL KILY S+       N  + Q+I MSATL N+ ++  WL AELY+ +YRP+ L+EM+K  + IYD      +D++    +       ++ D D +  LC+ET+LEG   +VFCP+K WCE ++  LA
Sbjct:  216 LPMSIQAEYKKKGVVDMFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKKVLLILPFISVVREKMFYMQDLLTPAGYRVEGFYGGYTPPGGFESLHVAICTIEKANSIVNKLMEQGKLETIGMVVVDEVHLISDKGRGYILELLLAKILYMSRR------NGLQIQVITMSATLENVQLLQSWLDAELYITNYRPVALKEMIKVGTVIYDHRLKLVRDVAKQKVLLKG----LENDSDDVALLCIETLLEGCSVIVFCPSKDWCENLAVQLA 492

HSP 2 Score: 207.608 bits (527), Expect = 3.664e-52
Identity = 171/632 (27.06%), Postives = 288/632 (45.57%), Query Frame = 2

Query: 3587 VYYLNL-LNPIGSRVNVSLKRRSEFLVDLLSLPHFLFVSFDWIFVLSLLERKLNQHFMKHDNLIDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIG----DRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKEV-KRTVDILKQMA---FIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNAS-HGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
             YY N+ ++   +   V    + + L +L++      V  D    L +L + + Q       L D  + +W+L  +   + FL++C  +          P    L ++   G       L  S+ I      A ++ V L I     +   ++   +  L K F  IEM I   + Q    G  F   + +++++ +R V ++K++    +   G  FN+ S + V+K+L +  +        G   T +    K+ +     +               YR L  L+ K++ PL E C+   I   +            ++TGR++ T PNLQ+V                       AKE  I    D V  + RS F  +     L++AD+ QLE+RIL+H S+D AL+     +   D+FI +A+ W K     +T   R   KQ+ YGI+YG+  + L+E ++  E +A  + ++F  A+ G+  +    ++  R  GF+ETITGRRRYL +I S+    ++ AERQA++STIQGSAADI K A++ ++  I    +  +    S++    +V+HLHDE+++EVP      +A +L   ME    L V L VK++ G  W E  +  V
Sbjct: 1499 AYYWNMQIDERAAYQGVPTPLKVQELCNLMARKDLTLVMHDGKEQLKMLRKAIPQLKRISAKLEDAKVANWLLQPDKTVN-FLNMCQTF---------APECTGLANLCGSGRGYSSYGLDTSSAILPRIRTAIESCVTLHILQGQTEN--LSRIGNGDLLKFFHDIEMPIQLTLCQMELVG--FPAQKQRLQQLYQRMVAVMKKVETKIYEQHGSRFNLGSSQAVAKVLGLHRKA------KGRVTTSRQVLEKLNSPISHLILG-------------YRKLSGLLAKSIQPLMECCQADRIHGQSIT---------YTATGRISMTEPNLQNV-----------------------AKEFSIQVGSDVVHISCRSPFMPTDESRCLLSADFCQLEMRILAHMSQDKALLEVM--KSSQDLFIAIAAHWNKIEESEVTQDLRNSTKQVCYGIVYGMGMRSLAESLNCSEQEARMISDQFHQAYKGIRDYTTRVVNFARSKGFVETITGRRRYLENINSDVEHLKNQAERQAVNSTIQGSAADIAKNAILKMEKNIERYREKLALGDNSVD----LVMHLHDELIFEVPTGKAKKIAKVLSLTMENCVKLSVPLKVKLRIGRSWGEFKEVSV 2059

HSP 3 Score: 149.443 bits (376), Expect = 1.805e-34
Identity = 92/272 (33.82%), Postives = 145/272 (53.31%), Query Frame = 2

Query:  917 GCLVFCPTKKWCETMSKNLAKELTPVYLSMNTA-------IDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKS-LKLEEAAMEMISESQMLLKRDLQLMGIEW 1708
            G ++F   +K     S  L  EL  VYL    +       IDW  + ++    S    +V  LVG+ + FL K ++ G+T   +     ++RFY +L L  LVNE     V  K+   +G LQSLQ  A+T+AG+VT FCN L WS L ++++ F+ R+ FG+  DL+DL+R+  ++  RAR  F AG+ ++  +AGA   E+  +L  S+ F SAK  DH    +    N  R     GK+ + + EAA  +I E++  ++ ++ L  I+W
Sbjct:  753 GLILFAELQK--SRRSFVLESELHAVYLVTPYSVCYQLQDIDWLLYVHMWEKLSSPMKKVGELVGVRDAFLYK-ALRGQTKLDYKQMQIHKRFYIALALEELVNETPINVVVHKYKCHRGMLQSLQQMASTFAGIVTAFCNSLQWSTLALIVSQFKDRLFFGIHRDLIDLMRIPDLSQKRARALFDAGITSLVELAGADPVELEKVLYNSISFDSAKQHDHENADEAAKRNVVRNFYITGKAGMTVSEAAKLLIGEARQFVQHEIGLGTIKW 1021

[Close]

BLAST of DNA polymerase theta vs. UniProt/SwissProt
Match: sp|Q588V7|TEB_ARATH (Helicase and polymerase-containing protein TEBICHI OS=Arabidopsis thaliana OX=3702 GN=TEB PE=2 SV=1)

HSP 1 Score: 221.861 bits (564), Expect = 1.529e-56
Identity = 131/326 (40.18%), Postives = 204/326 (62.58%), Query Frame = 2

Query:  122 NVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVD--IAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHS--------------KTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL--TPV--------YLSMNTAID 1021
            + +LP  V + YN+ GI+ L+ WQ EC++++GVL   +NLVY A TSAGK+ V+E+++L+RV+   K  L +LPYVS+  EK  + + L   +G  +  + G+    GG    D  +AVCTIEKAN+L+NRL+++G L EL ++VIDELHM+GD+HRGY+LEL+LTK+ Y +               +  + DP +   QI+GMSAT+PN+  VA WL+A LY  ++RP+PL+E +K  S IY+ K     +R     + +   D D I+ LC E + EG+  L+FC ++K CE+ +++++K +   PV        ++ + +AID
Sbjct:  496 STWLPSEVCSVYNKKGISKLYPWQVECLQVDGVLQ-KRNLVYCASTSAGKSFVAEVLMLRRVIRTGKMALLVLPYVSICAEKAEHLEVLLEPLGKHVRSYYGNQG--GGTLPKDTSVAVCTIEKANSLINRLLEEGRLSELGIIVIDELHMVGDQHRGYLLELMLTKLRYAAGEGSSESSSGESSGTSSGKADPAH-GLQIVGMSATMPNVGAVADWLQAALYQTEFRPVPLEEYIKVGSTIYNKK--MEVVRTIPKAADMGGKDPDHIVELCNEVVQEGNSVLIFCSSRKGCESTARHISKLIKNVPVNVDGENSEFMDIRSAID 815

HSP 2 Score: 218.009 bits (554), Expect = 2.238e-55
Identity = 158/483 (32.71%), Postives = 261/483 (54.04%), Query Frame = 2

Query: 4040 SSSLYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKE---VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKX-XXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSS-TGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCF-NASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKS--------FHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            S  L +  + IEM +  ++     +G+   + E  ++    ++  +  L++ AF ++G TF++ +P +++ +LF +++ P         I    S  K+  ST K+ L+ L + HP+  +I E+R L  L+  TL  +   C    +  ST    +   + Q S+ TGRL+   PNLQSV   ++   FKL   + RD          +  + D    N R  F      ++L+TADY Q+ELR+++HFSRD +LI   ++QP+ D+F  +A+KW  K  +S++  DR Q K++ YGI+YG+ A  L+EQ+     +A++ I  F  +FP V+ ++  TI  C++ G+I+T+ GRRR+L  I   N   +S A+RQA++S  QGSAADI+K AM+ + +AI  D    +        FH   L     ++L +HDE++ EV  +Y+   A++L+  ME +  L V L VK+K G  W  L  F
Sbjct: 1699 SEELLQALTTIEMPLVNVLADMELWGIGIDI-EGCLRARNILRDKLRSLEKKAFELAGMTFSLHNPADIANVLFGQLKLP---------IPENQSKGKLHPSTDKHCLDLLRNEHPVVPIIKEHRTLAKLLNCTLGSI---CSLAKLRLSTQRYTLHGRWLQTSTATGRLSIEEPNLQSVEHEVE---FKL-DKNGRD----------VSSDADRYKINARDFFVPTQENWLLLTADYSQIELRLMAHFSRDSSLISK-LSQPEGDVFTMIAAKWTGKAEDSVSPHDRDQTKRLIYGILYGMGANRLAEQLECTSDEAKEKIRSFKSSFPAVTSWLNETISFCQEKGYIQTLKGRRRFLSKIKFGNAKEKSKAQRQAVNSMCQGSAADIIKIAMINIYSAIAEDVDTAASSSSSETRFHM--LKGRCRILLQVHDELVLEVDPSYVKLAAMLLQTSMENAVSLLVPLHVKLKVGKTWGSLEPF 2151

HSP 3 Score: 120.553 bits (301), Expect = 1.001e-25
Identity = 80/246 (32.52%), Postives = 119/246 (48.37%), Query Frame = 2

Query:  971 LAKELTPVYL--SMNTAID--WTCFYNVVNSFSEAELRVMILVGIEEKFL-----------------IKYSVSGRTSTRH--------SDDPKYR---RFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGD---HIEEMKYNSNNSDRIL 1603
            +A +L  VYL   +N  ++  W  +Y      S  E  V   VG+ E FL                 +K ++ G   +RH        SD+   R   RF+ +LIL  LV E S  +V E F V +G +Q+LQ  A  ++ MV++FC RLGW  LE L+  FQ R+ FGV  ++V+L  +  +   RAR  +KAGL T  +IA A + EI   L +S  + +   G    H+   K   N + +I+
Sbjct: 1047 MASDLHLVYLVTPINVGVEPNWELYYERFMELSPLEQSVGNRVGVVEPFLMRMAHGATVRTLNRPQDVKKNLRGEYDSRHGSTSMKMLSDEQMLRVCKRFFVALILSKLVQEASVTEVCEAFKVARGMVQALQENAGRFSSMVSVFCERLGWHDLEGLVAKFQNRVSFGVRAEIVELTSIPYIKGSRARALYKAGLRTSQAIAEASIPEIVKALFESSAWAAEGTGQRRIHLGLAKKIKNGARKIV 1292

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BLAST of DNA polymerase theta vs. UniProt/SwissProt
Match: sp|Q9CDS1|DPO1_LACLA (DNA polymerase I OS=Lactococcus lactis subsp. lactis (strain IL1403) OX=272623 GN=polA PE=3 SV=1)

HSP 1 Score: 204.142 bits (518), Expect = 2.788e-52
Identity = 141/444 (31.76%), Postives = 228/444 (51.35%), Query Frame = 2

Query: 4109 GFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIY-QQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITA-DYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSE 5434
            G  V+ + +E    E +  +  L +  + ++G+ FNI+SPK++  +LF +++ PV      GK T+   ++ +       L  L +L P+   ILEYR +        N +     K +I     + KI   Y Q L+ TGRL+S  PNLQ++P  ++                                   R  F  S   +L+++DY Q+ELR+L+H S D  LI  F +  D+     M    ++K  E +T  DR+ AK +++G++YGIS  GL+  + I    A+  I  +   +PG+  ++++ +   R  GF+ET++ RRR +PDI + N   R  AER AI+S IQGSAADI+K AM+ +D A++A D+K+K            ++L +HDEI+ +VPL  +  + V++KQ ME++ +L V L V   TG  W E
Sbjct:  494 GIAVSQNTLEEIGAENEEKLASLTREIYDLAGEEFNINSPKQLGVILFEKLQLPV------GKKTKTGYSTAVDV-----LEDLAALSPVVAKILEYRQI--------NKVQSTYVKGLIPQIADDGKIHTRYVQDLTQTGRLSSVDPNLQNIPVRLEEGR------------------------------KIRKAFVPSKDSLLLSSDYSQIELRVLAHISGDEHLIDAFKHGADIHTSTAMRVFGIEKA-EDVTANDRRNAKAVNFGVVYGISDFGLARNLGITRKDAKNYIETYFERYPGIKTYMENIVREARDKGFVETMSHRRRKIPDINARNFNVRGFAERTAINSPIQGSAADILKIAMINLDKALSARDFKSK------------LLLQVHDEIILDVPLEELDEIKVLVKQTMEEAIELAVPLKVDENTGKTWYE 875

[Close]

BLAST of DNA polymerase theta vs. TrEMBL
Match: A0A2P8Y3P5 (Helicase ATP-binding domain-containing protein OS=Blattella germanica OX=6973 GN=C0J52_07902 PE=4 SV=1)

HSP 1 Score: 376.326 bits (965), Expect = 7.007e-102
Identity = 241/578 (41.70%), Postives = 336/578 (58.13%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRM---FNCP-------------SGVIK-TDEDQILGLCLETILEGHGCLVFCPT-------------------------KKWCETMSKNL--AKELTPVYL-SMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKY---SVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDR---ILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWN 1711
            LP+ V  +Y  LG+ S+F WQ EC+  + VL G  NL+YSAPTSAGKTLV+E++++K VLE KKK + ILP+VSV +EKM YFQ L    G+++ G MG  S  GG   VDIAVCTIEKAN LVNRL+++GSL ++  +V+DELH+LGD  RGYILELLLTKILY  K+   ND    + QIIGMSATLPNL ++A WL AELY  D+RP+PL+E +K    +      STP ++    NC              +  +K  +E +++ L  E + EG   L + PT                          + C  +  +L    E+TP  + S    +DW    N+         RV  LVG+EE+F+++    ++S  TS +      +RRFY++L L+ LVNE     V +K+   +G LQSLQ  AAT+AGMVT FC RLGWS +E+L++ FQ R+ FGV  +L DL++L  +N  RAR  +  G+ +++ +A A V E+ N L K++PFQS K  D     +    N  R   I G  G  L   EAA  +ISE++  L+++L L   +W+
Sbjct:   37 LPETVLKRYELLGVVSMFPWQVECLSNSNVLSGG-NLIYSAPTSAGKTLVAEMLIIKTVLEKKKKAILILPFVSVVREKMFYFQNLLSSSGIRVEGLMGSHSLPGGFKNVDIAVCTIEKANGLVNRLLEEGSLHKVGAVVVDELHLLGDSFRGYILELLLTKILYMCKS---NDS--VKIQIIGMSATLPNLTLLATWLGAELYRTDFRPVPLKEYLKIGPTVIASGVASTPEQVEQYTNCTLLATTDSDLQNPVTACVKFLEESELIRLQKEEVGEG---LKYSPTPLGLACLAASLPPDDGLRLFEELQRARHCFVLDTDLHIIYEVTPYSVCSQWGNLDWLHVLNLWEQLPPIMQRVGELVGVEERFMVRAMRGTMSFTTSKQLQKLSIHRRFYTALALHDLVNEVPLNDVAKKYGCTRGMLQSLQQSAATFAGMVTAFCKRLGWSSVELLISQFQDRLQFGVHRELCDLMKLDGLNGQRARALYDEGITSLADLAIADVCEVENALHKAVPFQSTKELDGETSFETKQRNKQRNVWITGHEG--LTEREAATLLISEARSYLQKELGLADAKWD 603

HSP 2 Score: 188.734 bits (478), Expect = 6.482e-44
Identity = 97/248 (39.11%), Postives = 145/248 (58.47%), Query Frame = 2

Query: 4715 VLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITA----DYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            V V+ADY QLELRIL+H ++D  L        D D+F  +A+ W K     +T+  RQ AKQ+ YGIIYG+ A+ L                       GV +++  T+++CR+ G++ET+ GRRRYL  I + N   R+ AERQA+++T+QGSAAD+ K AMV+VD+ + +      +  + +RK  N    +VLH+HDE+LYEV  +++   A I+K+ +E +  L V LPVKVK G  W  + + 
Sbjct: 1828 VFVSADYSQLELRILAHLAKDSVLSSIL--NADCDVFRNIAASWNKIDEAQVTNEQRQWAKQVCYGIIYGMGAKAL-----------------------GVKKYLLETVELCRREGYVETLLGRRRYLSGIHNPNSAIRAQAERQAVNTTVQGSAADVAKKAMVLVDSQLNSAGFISSEMGTGNRKEAN----LVLHIHDELLYEVSRDHLMEAAHIIKEALENAVKLSVKLPVKVKVGESWGSIKEI 2046

[Close]

BLAST of DNA polymerase theta vs. TrEMBL
Match: K1QA60 (DNA polymerase theta OS=Crassostrea gigas OX=29159 GN=CGI_10013103 PE=4 SV=1)

HSP 1 Score: 300.827 bits (769), Expect = 4.294e-78
Identity = 175/388 (45.10%), Postives = 248/388 (63.92%), Query Frame = 2

Query:   95 GDEIIIDKDNVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRET------QIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEL------TPVYLSMNTA-----------IDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTS----TRHSDDPKYRRFY 1177
            GD++++   N  LP+ V  QY++ GITS+F WQ+EC+ L GVLDG  NLVYSAPTSAGKT+V+E+++LKRVLE KKK + ILP+VSV++EKM Y Q+L+  +G+ + GFMG  SP GGL+ VD+AVCTIEK N L+NRL+++  L++L ++VIDELH++GD+HRGY+LEL+LTKI + S+ MK+ DP   E+      QIIGMSATLPNL+++A+WL A LY  DYRP+PL E +K  + I+D +     IR  +  S   K D D ++ LCLET+ +GH  L+FCPTK WCE +++ +A+E        PV +  N             +       VV       + +   +G    + + Y  +G+       R  +DP   R Y
Sbjct:  140 GDKLLLK--NWGLPEPVMKQYSDKGITSMFEWQAECLCLPGVLDGG-NLVYSAPTSAGKTMVAELLVLKRVLETKKKAIIILPFVSVAREKMFYLQQLYQEVGVSVSGFMGSYSPPGGLSQVDVAVCTIEKGNGLINRLMEENRLDQLGIVVIDELHLVGDQHRGYLLELMLTKIRFLSQRMKKPDPQNMESSSTEGIQIIGMSATLPNLDLLARWLDATLYRTDYRPVPLTECVKLGADIFDSR--LQKIREVDL-SVTFKGDTDHVVPLCLETLRDGHSVLIFCPTKNWCEKLAETIAREFYGILKKAPVDMQANQGSGGNPPSPCLPLSRASLQEVVEQLRRTPVGLDSTLGKTVPYGVAYHHAGKYQHKFIVRVKEDPGGARLY 521

HSP 2 Score: 251.521 bits (641), Expect = 5.038e-63
Identity = 163/456 (35.75%), Postives = 256/456 (56.14%), Query Frame = 2

Query: 4175 LKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNG-GKITRKNSTSKIT---------ASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQIN----------WFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADY----KNKSFHRKSLNQIP------AMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            L++ A+   G  F++ S +++S++LFIE++ PV G  +  G+  R N  +  +         ++TK+ L  L  LHP PG++LE+R +   + K +   F   K+ V   +    +I    Q  ++TGR++ + PNLQ+VPK   I+          W    H       +NK +  G    + S   + R  F    G VL+ ADY QLELR+++H S+D  LI       D D+F  + ++W    +E +T   RQQAKQI YG+IYGI A+ L + + +EE+ A   I  F   +PG+ +++K T+D C KNG++ETI+GRRRYLP I ++ P+ R+HAERQA+++T+QGSAAD+VK AM  +D+ ++A +    K  S+    +  I        +VL LHDE++YEV    +   A ++K+ ME +  L V +PVKVK+G  W+ + D  V
Sbjct: 2235 LEEQAYRCVGHQFSLTSTEDLSQILFIELQLPVNGDPSSLGQPMRPNRRAPNSHRGRQKSQFSTTKEVLEKLRPLHPFPGILLEWRRISGSLTKVV---FALQKEKVYCENLGMHRIFTDVQYFTATGRVSLSEPNLQNVPKDFLISVSAPVENFNQWDAAGH-------RNKNRNSG----QTSFNVSMRHAFIPFPGGVLLAADYSQLELRMIAHLSQDSKLIKIL--NGDGDVFKLITAQWKSISVEEVTPEQRQQAKQICYGMIYGIGAKALGDTLGVEENDAAAFIQTFKSKYPGMRRYLKDTVDKCCKNGYVETISGRRRYLPSISNKKPYVRAHAERQAVNTTVQGSAADLVKVAMNRIDDRLSAMFPLSKKTFSYKEDEVQGIELSSDRCCLVLQLHDELIYEVTERCLGQAAKVIKEEMETAMTLSVKMPVKVKSGLSWATMQDLAV 2674

HSP 3 Score: 197.978 bits (502), Expect = 9.409e-47
Identity = 104/283 (36.75%), Postives = 169/283 (59.72%), Query Frame = 2

Query:  983 LTPVY-LSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPK----YRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLE-EAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSN 1813
            +TP+Y L +   ++W  FY + +  S  + RV  LVG+ E FL + ++ GR  T+  +  +    ++RFY+SLIL  LV E    +V  ++   KG LQSLQ  AAT+AGMVT+FC RLGW +LE+++  FQ R+ FG+  +L DLVRL+L+N  RAR+ +  G  T++++A A V ++  + +KS PFQS+K  ++  E +       R +   G+    E EAA  +I E++ L++++L  +GI+W  P   K   ++ E S+ +   +D +  L KS++N
Sbjct:  765 VTPIYSLDLGAGMNWYKFYCLWDKLSPDKKRVAQLVGVSEAFLTR-AIQGRIPTKTENQIRSLAIHKRFYTSLILSDLVQEVPLGEVCHRYGANKGQLQSLQQTAATFAGMVTVFCARLGWYNLELILGQFQHRLTFGIQRELCDLVRLTLLNGQRARVLYDGGFHTVAALANASVSDVEKIFKKSSPFQSSKKLENETEWEAARRQESRCIWLTGRKGATEREAAQAIIQEAKSLIQQELGGLGIQWKTPDTRK---SLEEGSNPDQNGMDCSRDLEKSSNN 1043

[Close]

BLAST of DNA polymerase theta vs. TrEMBL
Match: A0A1S3FF85 (DNA polymerase theta OS=Dipodomys ordii OX=10020 GN=Polq PE=4 SV=1)

HSP 1 Score: 295.049 bits (754), Expect = 1.864e-76
Identity = 205/570 (35.96%), Postives = 318/570 (55.79%), Query Frame = 2

Query:  122 NVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEEL--SLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDP-------NYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAK---------------------ELTPVYLSMN-----TAIDWTCFYNVVNSFSEAELRVMILVGIEEKFL---IKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSA-KVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNP 1714
            N  LP+ V  +Y+  G+  +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLV+E+++LKRVLE++KK LFILP+VSV+KEK  Y Q LF  +G+K+ G+MG  SP G  +++DIAVCTIE+AN L+NRLI++  ++ L  S+LV        ++ +G  L     K +      +E D           E  + G+++T  ++   A         C +    ++E  +   +  D   L     +  C   +++ +  QI G       +G    V+ PT     T+S +L+                      +L  VYL        T IDW  F+ +      +  RV  LVG+EE FL   +K  V  RT  +H     ++RF++SL+L  L+NE S +++ +K+   +G +QSLQ  AA YAGM+T+F NRLGW ++E+L++ FQ+R+ FG+  +L DLVR+SL+NA RAR  + +G  T++ +A A + E+  +L+ ++PF+SA K  D  EE      N   I     K L   EAA+ ++ E++M+L++DL  +G++W+P
Sbjct:   76 NWGLPKEVLEKYHSFGVKKMFEWQAECLLLGQVLEG-KNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSSSPAGHFSSLDIAVCTIERANGLINRLIEENKMDLLGESILVCKN----SEKSKGIALLQGSLKPVRSCLQRREGDEITASMVRAILEIIVGGVASTSRDMQTYAS--------CTFLAASMKEGKQGIQRNEDSVHLGA---IEACVLWLLENEFIQIAGAS-----DGSEGKVYHPTHLGSATLSSSLSPTDTLDIFADLQRAMKGFVLENDLHIVYLVTPMFEDWTTIDWYRFFCLWEKLPASMKRVAELVGVEEGFLARSVKGKVVARTERQHRQMAIHKRFFTSLVLLDLINEVSLKEINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARFLYSSGFLTVADLARANIAEVEVVLKNAVPFKSARKAVDEEEEAAEERRNMQTIWVTGRKGLTANEAAVLIVEEAKMILQQDLVELGVQWDP 624

HSP 2 Score: 243.817 bits (621), Expect = 9.253e-61
Identity = 178/532 (33.46%), Postives = 272/532 (51.13%), Query Frame = 2

Query: 4049 LYKHFSFIEMNISYIIDQAPGFGVNFSVME--SQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG-------------IFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNP-----KIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKN----------------------EDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYK--NKSFHRKSL-----------NQIPAM---------VLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            L+  F  +EM   Y +      G+ FS  E  SQ   ++  +D ++  A+ ++G +F+  S  +++++LF+E++ P  G                G    RK+   +  +++K  LN L  LHPLPGLILE+R +   + K + PL +  K++       NP     +I  + Q  ++TGR++ T PN+Q+VP+  +I    LL         +K + L +  +                      E     + R  F    G +++ ADY QLELRIL+H S+D  LI         D+F  +A++W     ES+ D  RQQAKQI YGIIYGI A+ L EQM + E+ A   I+ F   + G+S F+K T+  C+++GF++TI GRRRYLP I   NP+ ++HAERQAI++T+QGSAADIVK A V +   +   +       HR+ +            ++P +         +L LHDE+LYEV    +  +A I+K  ME +  L V L V+VK G  W +L DF V
Sbjct: 1786 LHDVFCNVEMPSQYCLALLELNGIGFSTTECESQKHILQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNGEMKIQGNKKTLGSTRRGNDTGRKSRLGRRFSTSKDVLNKLKELHPLPGLILEWRRISSAITKVVFPL-QREKRL-------NPFLGMERIYPVSQSHTATGRISFTEPNIQNVPRDFEIRMPTLLDESSPSQVLDKGQPLMVRGHSKKGCGLYPEHRAPVDEQALAREVPFSVSMRHAFVPFPGGLILAADYSQLELRILAHLSQDHRLIQVL--NTGADVFRSIAAEWKMIKPESVGDDLRQQAKQICYGIIYGIGAKSLGEQMGVTENDAACYIDSFKSRYTGISHFMKETVKNCKRDGFVQTILGRRRYLPGIKDNNPYHKAHAERQAINTTVQGSAADIVKVATVNIQKKLETFHSIFKSHGHREGMLQRDRAGLLLKGRLPGIFCPIRGGFFILQLHDELLYEVAEEDVFKVAQIVKNEMESAIKLSVKLKVRVKLGASWGDLKDFDV 2307

[Close]

BLAST of DNA polymerase theta vs. TrEMBL
Match: A0A2G8JBX8 (Putative DNA polymerase theta-like OS=Stichopus japonicus OX=307972 GN=BSL78_29939 PE=4 SV=1)

HSP 1 Score: 278.87 bits (712), Expect = 3.140e-76
Identity = 149/286 (52.10%), Postives = 209/286 (73.08%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELT 988
            LP+ V NQY  +G+ ++F WQ +C++   VL G  NL+YSAPTSAGKTLV+E+++LK+VLE KKK + ILP+VSVS+EKM Y Q L     +++ GFMG  SP GGL +VD+AVCTIEKAN+L+NRL+++  L++L ++V+DELHM+GD HRGY+LELLLTK+ Y    +   + N    QI+GMSATLPNL+++A+WL A+LY  D+RP+PL E +K    +YD +   +  + F+    V + DED I  LCLET+  G G L+FCPTK WCE +++N+A+EL+
Sbjct:  309 LPEAVLNQYYLMGVQNMFPWQVQCLRKGKVLQGG-NLIYSAPTSAGKTLVAELLVLKKVLESKKKAIIILPFVSVSREKMFYLQNLLQDTNVRVDGFMGSHSPPGGLKSVDVAVCTIEKANSLINRLLEENKLDQLGIIVVDELHMVGDSHRGYLLELLLTKVKY----VTSAETNRTSIQIVGMSATLPNLDLLAKWLDADLYSTDFRPVPLTEFVKIGPSLYDSQ--MSHAKNFDLKYDV-QNDEDHIFSLCLETMAMGCGVLIFCPTKNWCEKLAENMARELS 586

[Close]

BLAST of DNA polymerase theta vs. TrEMBL
Match: W5KBV8 (Polymerase (DNA directed), theta OS=Astyanax mexicanus OX=7994 PE=4 SV=2)

HSP 1 Score: 293.508 bits (750), Expect = 7.182e-76
Identity = 156/292 (53.42%), Postives = 213/292 (72.95%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKE--NDPNYRE-TQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVY 997
            LP+ V  +Y  LG+  +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLVSE+++LKRVLE ++K +FILP+VSV++EKM Y Q +F   G+++ G+MG  S  GG + +D+AVCTIEKAN L+NRLI++  ++ L ++V+DELHMLGD  RGY+LELLLTKI Y +   KE   D  Y +  QI+GMSATLPNL+++A+WL AELY  DYRP+PL E +K  ++IYD     T IR F  P+  +K D+D I+ LC ET+  GH  L+FCP+K WCE ++ ++A+E   +Y
Sbjct:  253 LPKPVLEKYQSLGVKQMFEWQAECLTLGKVLEG-KNLVYSAPTSAGKTLVSELLILKRVLETRRKAIFILPFVSVAREKMFYLQNVFQEAGVRVEGYMGSTSAAGGFSALDVAVCTIEKANGLINRLIEEDRMDLLGIVVVDELHMLGDSGRGYLLELLLTKIQYIATKTKERCTDKAYTDGVQIVGMSATLPNLDLLARWLSAELYHTDYRPVPLMEWVKIGTQIYDGS--MTLIRQFT-PALPVKGDDDHIVSLCFETVHAGHSALLFCPSKNWCEKLADSIAREFYNLY 540

HSP 2 Score: 227.254 bits (578), Expect = 1.306e-55
Identity = 162/513 (31.58%), Postives = 263/513 (51.27%), Query Frame = 2

Query: 4061 FSFIEMNISYIIDQAPGFGVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNG-------GKITRKNSTSKIT-----ASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLL--------------HLDKRDLFKNKAKELGIDKNEDS-------VICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKN-KSFHRKSLNQIPA---------------MVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            F  +EM   Y +      G+ FSV E + ++  ++  +  L+  A+ ++G +F++ SP +V+++LF+E++ P  G  N        G   R  + +++      ++TK  L  L  LH LPG+ILE+R +   + K + PL    ++ +        +I  + Q  ++TGR++ T PN+Q+VPK  +I    L+                 +  + +   + + + K+ D           + R  F    G +++ ADY QLELRIL+H S D  L+    +  DV  F  +A++W      ++ D  RQQAKQI YGIIYG+ A+ L EQM I+E+ A   I  F   + G+  F++ T+  C KNGF++T+ GR+R+LP I   N + +SHAERQA+++T+QGSAADIVK A V + + + A +      H+ + ++                   +L LHDE++YEV    +  +A I+K  ME +  L V L  KVK G  W  L D 
Sbjct: 2147 FQRVEMPTQYCLALLELNGIGFSVAECEAQKHVMQAKLSDLESQAYQLAGHSFSLTSPDDVAEVLFLELKLPPNGDLNSLKNKKTLGYTRRAGAGARVKLSKQFSTTKDVLEKLKPLHQLPGVILEWRRITNAMTKVVFPL---QREKIWHPKLKMDRIHPVSQSHTATGRVSFTEPNIQNVPKDFEIQMPTLIGESQPSQNHTTGVSSKSRNTISRTNHQLIALVKDSDKSPGKGMPFFVSMRHAFVPFSGGLILAADYSQLELRILAHLSCDKRLLQVLNSGEDV--FKSIAAEWKMVDPAAVDDSTRQQAKQICYGIIYGMGAKSLGEQMGIDENDAACYIESFKARYTGIQAFLRETVKNCSKNGFVKTLLGRKRFLPGIKDSNVYIKSHAERQAVNTTVQGSAADIVKLATVNIQHRLEATFPGVPQSHQHNPSETADHGRYRSRSRPFRGAFFILQLHDELIYEVAEEDIIQVAQIVKWEMESAMKLYVKLRAKVKVGPSWGNLQDL 2654

HSP 3 Score: 195.667 bits (496), Expect = 5.246e-46
Identity = 113/296 (38.18%), Postives = 174/296 (58.78%), Query Frame = 2

Query:  980 ELTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGR----TSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKS-LKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKI------DENISE-VSDSNIPQIDI---NNSLNKSTSNDKE 1822
            ++TPVY+   T IDW  F+ +      A  RV  +VGI+E FL + SV G+    T  +      ++RF+++L+L  LV+E     V +K+   +G LQSLQ  A+TYAGMVT+FCNRLGW +LE+L++ FQ R+ FGV  +L DLVR+SL+NA RAR  + AG  T++ IA     ++   LRK+ PF+S++              S R +  +GK  L   EAA +++ E+++ L++DL L+G+EWNP  L         DE+ SE + DS I  + +   +++   +T +D+E
Sbjct:  818 QITPVYVDWTT-IDWYQFFCLWEQLPSAMKRVAEMVGIQESFLAR-SVGGKLIAKTEKQRRQMAIHKRFFTTLVLLDLVSEEPLGAVAKKYGCSRGQLQSLQQSASTYAGMVTVFCNRLGWHNLELLLSQFQSRLSFGVQRELCDLVRISLLNAQRARALYSAGFVTVAEIARGNTADVEKALRKATPFKSSRQAVDESAEDAQERRSMRCIYVSGKKPLTESEAAKQIVLEARLHLQQDLALLGVEWNPELLSPKTQTNSGDESTSEKLQDSKIQTVKMQTESSAGEHNTHSDRE 1111

[Close]

BLAST of DNA polymerase theta vs. Ensembl Cavefish
Match: polq (DNA polymerase theta [Source:NCBI gene;Acc:103039702])

HSP 1 Score: 293.508 bits (750), Expect = 2.720e-79
Identity = 156/292 (53.42%), Postives = 213/292 (72.95%), Query Frame = 2

Query:  131 LPQNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKE--NDPNYRE-TQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVY 997
            LP+ V  +Y  LG+  +F WQ+EC+ L  VL+G KNLVYSAPTSAGKTLVSE+++LKRVLE ++K +FILP+VSV++EKM Y Q +F   G+++ G+MG  S  GG + +D+AVCTIEKAN L+NRLI++  ++ L ++V+DELHMLGD  RGY+LELLLTKI Y +   KE   D  Y +  QI+GMSATLPNL+++A+WL AELY  DYRP+PL E +K  ++IYD     T IR F  P+  +K D+D I+ LC ET+  GH  L+FCP+K WCE ++ ++A+E   +Y
Sbjct:  253 LPKPVLEKYQSLGVKQMFEWQAECLTLGKVLEG-KNLVYSAPTSAGKTLVSELLILKRVLETRRKAIFILPFVSVAREKMFYLQNVFQEAGVRVEGYMGSTSAAGGFSALDVAVCTIEKANGLINRLIEEDRMDLLGIVVVDELHMLGDSGRGYLLELLLTKIQYIATKTKERCTDKAYTDGVQIVGMSATLPNLDLLARWLSAELYHTDYRPVPLMEWVKIGTQIYDGS--MTLIRQFT-PALPVKGDDDHIVSLCFETVHAGHSALLFCPSKNWCEKLADSIAREFYNLY 540

HSP 2 Score: 227.254 bits (578), Expect = 4.948e-59
Identity = 162/513 (31.58%), Postives = 263/513 (51.27%), Query Frame = 2

Query: 4061 FSFIEMNISYIIDQAPGFGVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNG-------GKITRKNSTSKIT-----ASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLL--------------HLDKRDLFKNKAKELGIDKNEDS-------VICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKN-KSFHRKSLNQIPA---------------MVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDF 5446
            F  +EM   Y +      G+ FSV E + ++  ++  +  L+  A+ ++G +F++ SP +V+++LF+E++ P  G  N        G   R  + +++      ++TK  L  L  LH LPG+ILE+R +   + K + PL    ++ +        +I  + Q  ++TGR++ T PN+Q+VPK  +I    L+                 +  + +   + + + K+ D           + R  F    G +++ ADY QLELRIL+H S D  L+    +  DV  F  +A++W      ++ D  RQQAKQI YGIIYG+ A+ L EQM I+E+ A   I  F   + G+  F++ T+  C KNGF++T+ GR+R+LP I   N + +SHAERQA+++T+QGSAADIVK A V + + + A +      H+ + ++                   +L LHDE++YEV    +  +A I+K  ME +  L V L  KVK G  W  L D 
Sbjct: 2147 FQRVEMPTQYCLALLELNGIGFSVAECEAQKHVMQAKLSDLESQAYQLAGHSFSLTSPDDVAEVLFLELKLPPNGDLNSLKNKKTLGYTRRAGAGARVKLSKQFSTTKDVLEKLKPLHQLPGVILEWRRITNAMTKVVFPL---QREKIWHPKLKMDRIHPVSQSHTATGRVSFTEPNIQNVPKDFEIQMPTLIGESQPSQNHTTGVSSKSRNTISRTNHQLIALVKDSDKSPGKGMPFFVSMRHAFVPFSGGLILAADYSQLELRILAHLSCDKRLLQVLNSGEDV--FKSIAAEWKMVDPAAVDDSTRQQAKQICYGIIYGMGAKSLGEQMGIDENDAACYIESFKARYTGIQAFLRETVKNCSKNGFVKTLLGRKRFLPGIKDSNVYIKSHAERQAVNTTVQGSAADIVKLATVNIQHRLEATFPGVPQSHQHNPSETADHGRYRSRSRPFRGAFFILQLHDELIYEVAEEDIIQVAQIVKWEMESAMKLYVKLRAKVKVGPSWGNLQDL 2654

HSP 3 Score: 195.667 bits (496), Expect = 1.987e-49
Identity = 113/296 (38.18%), Postives = 174/296 (58.78%), Query Frame = 2

Query:  980 ELTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGR----TSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKS-LKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKI------DENISE-VSDSNIPQIDI---NNSLNKSTSNDKE 1822
            ++TPVY+   T IDW  F+ +      A  RV  +VGI+E FL + SV G+    T  +      ++RF+++L+L  LV+E     V +K+   +G LQSLQ  A+TYAGMVT+FCNRLGW +LE+L++ FQ R+ FGV  +L DLVR+SL+NA RAR  + AG  T++ IA     ++   LRK+ PF+S++              S R +  +GK  L   EAA +++ E+++ L++DL L+G+EWNP  L         DE+ SE + DS I  + +   +++   +T +D+E
Sbjct:  818 QITPVYVDWTT-IDWYQFFCLWEQLPSAMKRVAEMVGIQESFLAR-SVGGKLIAKTEKQRRQMAIHKRFFTTLVLLDLVSEEPLGAVAKKYGCSRGQLQSLQQSASTYAGMVTVFCNRLGWHNLELLLSQFQSRLSFGVQRELCDLVRISLLNAQRARALYSAGFVTVAEIARGNTADVEKALRKATPFKSSRQAVDESAEDAQERRSMRCIYVSGKKPLTESEAAKQIVLEARLHLQQDLALLGVEWNPELLSPKTQTNSGDESTSEKLQDSKIQTVKMQTESSAGEHNTHSDRE 1111

[Close]

BLAST of DNA polymerase theta vs. Ensembl Cavefish
Match: poln (polymerase (DNA directed) nu [Source:ZFIN;Acc:ZDB-GENE-100917-1])

HSP 1 Score: 179.874 bits (455), Expect = 3.197e-45
Identity = 107/336 (31.85%), Postives = 179/336 (53.27%), Query Frame = 2

Query: 4466 IANSTTNPKIKCIYQQLSS-TGRLNSTSPNLQSVPK-PIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEK-------SYDLKVSLPVKVKTGTVWSELNDF 5446
            I +  T   I   + Q S+ +GRL++  PN Q++PK PIQI         K+   + K  EL        V  + R+ F    G+  ++AD+ Q+ELR+L+H S DP L+  F N P+ D+F  +AS+W     ++++  DR+ AK+I Y ++YG   + LS  + +   +A +  + F+  +  V  FI+ T+  C K+G++++I GRRR LP + S +   R+ AERQA++  +QGSAAD+ K AM+ + + +++          S      +V  +HDE+L+EV  + + + AV++K+ ME           L V L V V  G  W  + + 
Sbjct:  678 ILSCVTKSFISSTWNQTSTVSGRLSAKHPNFQALPKQPIQIT--------KKQSVEGKESEL--------VTVHPRTMFIPREGWSFLSADFCQVELRLLAHLSSDPELLRIFQN-PEADVFTMLASQWKGVSKDTVSSEDREHAKRIVYSVVYGAGRERLSGILGVSSEEASRFQDTFLQTYREVQTFIQHTVQYCHKHGYVKSIMGRRRSLPHVHSTDWGIRNQAERQAVNFVVQGSAADLCKMAMIHICSHVSS----------SATLTARLVAQIHDELLFEVEDSQVEDFAVLVKKTMESLQHIDCLGVRLTVPLKVSVSKGRSWGSMCEL 986

[Close]

BLAST of DNA polymerase theta vs. Ensembl Cavefish
Match: helq (helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-060503-421])

HSP 1 Score: 169.859 bits (429), Expect = 4.013e-42
Identity = 117/304 (38.49%), Postives = 167/304 (54.93%), Query Frame = 2

Query:  167 GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLS------TPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTAIDWTCFYNVVNS 1051
            GI  L+ WQ  C+ L+ V    KNL+YS PTS GKTLV+EI++ K +L  +K  L ILPYV++ +EK   +  F      +  +  G  G   P    ++  + + TIEK ++LVN LI+   L+ + L+V+DELHMLGD  RG ILE+ L K+LY +K+          TQIIGMSATL N+  +  +L+AE Y  D+RP+ L+E +K    IY+ K         + +  F   SG+ K D D I+ L  E I +   CL+FC TKK CE ++  + K L   +L        T    + NS
Sbjct:  205 GIQDLYDWQKVCLDLDSV-KQRKNLIYSLPTSGGKTLVAEILIFKELLCRRKDALLILPYVALVQEKVRGLASFGIELDFMVEEYAGSKGRFPPVKRRSSNSLYITTIEKGHSLVNSLIEANRLDNIGLVVVDELHMLGDGSRGAILEMTLAKVLYINKS----------TQIIGMSATLGNIGDLQSFLRAENYTNDFRPVELKEYVKLRDSIYEVKPKEEECFRFSRLLAFKYSSGMQKMDPDHIIALVTEVIPK-QSCLIFCATKKNCENVAGMICKYLHTDFLMHREGEKATLLAELRNS 496

HSP 2 Score: 85.1149 bits (209), Expect = 5.264e-16
Identity = 53/213 (24.88%), Postives = 107/213 (50.23%), Query Frame = 2

Query:  947 WCETMSKNLAKEL---------------TPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLG--WSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAK----VKEITNLLRK 1522
            +C+ + ++L+K L               TP  L      DW  +Y   +  S AE ++   +G+ E F+ +   +G++  ++ D+    R Y +L+LY L+ E     V+++F + +G +Q+L   ++ +   V  F   L   W++ + L++   RR+ + V  +L+ L+ +S +   RA+  + AG +T++ +A A     VK++ NL +K
Sbjct:  695 YCDVLYRDLSKGLEGLLLNSFLHLVYLVTPYDLVSQCKPDWMIYYTQFSKLSPAEQKMAATLGVPESFVAR-KAAGQSVRKNVDNLVVNRLYLALVLYSLLRETDLWSVSDRFQMTRGFVQTLLSSSSAFCSCVLHFTEELEEFWAY-KALLSELTRRLTYCVQAELIPLMEVSGVMELRAKQLYSAGYKTLAHLANADPNVLVKKVENLFKK 905

[Close]

BLAST of DNA polymerase theta vs. Ensembl Cavefish
Match: helq (helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-060503-421])

HSP 1 Score: 102.064 bits (253), Expect = 4.827e-22
Identity = 67/156 (42.95%), Postives = 95/156 (60.90%), Query Frame = 2

Query:  167 GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILY 625
            GI  L+ WQ  C+ L+ V    KNL+YS PTS GKTLV+EI++ K +L  +K  L ILPYV++ +EK   +  F      +  +  G  G   P    ++  + + TIEK ++LVN LI+   L+ + L+V+DELHMLGD  RG ILE+ L K+LY
Sbjct:  260 GIQDLYDWQKVCLDLDSV-KQRKNLIYSLPTSGGKTLVAEILIFKELLCRRKDALLILPYVALVQEKVRGLASFGIELDFMVEEYAGSKGRFPPVKRRSSNSLYITTIEKGHSLVNSLIEANRLDNIGLVVVDELHMLGDGSRGAILEMTLAKVLY 414

[Close]

BLAST of DNA polymerase theta vs. Ensembl Cavefish
Match: ascc3 (activating signal cointegrator 1 complex subunit 3 [Source:NCBI gene;Acc:100332599])

HSP 1 Score: 68.5514 bits (166), Expect = 8.017e-11
Identity = 70/270 (25.93%), Postives = 126/270 (46.67%), Query Frame = 2

Query:  197 ECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXX----------XXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMS-PKGGLATVDIAVCTIEKANNLVNRLIDDGSLEEL-SLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYV------CDYRPIPLQEM---MKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTK 943
            + I      + ++NL+  APT AGKT ++ + +L  + +  +          K++++ P  +++ E   YF K    +G+ +    GDM   KG +    + V T EK + +  + + D  L ++  L+++DE+H+L  E RG +LE L+      ++T+++ +      +I+G+SATLPN   VA +L    Y+        +RP+PL +    +K  SKI    D+                 E+      LE I  GH  +VF   +
Sbjct:  480 QSIVFETAYNTNENLLICAPTGAGKTNIAMLTVLHEIRQHLQPGGVIRKDQFKIVYVAPMKALAAEMTNYFSKRLEPLGISVKELTGDMQLTKGEILRTQMLVTTPEKWDVVTRKSVGDVGLSQIVRLIILDEVHLL-HEDRGPVLESLV------ARTLRQVESTQSMIRILGLSATLPNYLDVASFLHVNPYIGLFFFDSRFRPVPLGQTFVGVKTTSKIQQLHDM-----------------EEVCYDKVLEQIRAGHQVMVFVHAR 725

HSP 2 Score: 58.9214 bits (141), Expect = 7.423e-8
Identity = 45/187 (24.06%), Postives = 100/187 (53.48%), Query Frame = 2

Query:  236 NLVYSAPTSAGKTLVSXXXXXXX-XXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXM-GDMSPK-GGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLK-AELYVCDY----RPIPLQ 772
            N++  APT +GKT+ +E+ + +        K ++I P  ++ +E++  ++        +    + GD++P    +A  D+ V T EK + +     +   ++++++L+IDE+H+LG E RG +LE+++++  + S          +  +++G+S  L N   +A WL   ++ + ++    RP+PL+
Sbjct: 1304 NVLLGAPTGSGKTIAAEMAIFRVFNKYPTAKAVYIAPLKALVRERIEDWKIRIEEKLGRKVVELTGDVTPDMRAIAQADLIVTTPEKWDGVSRSWQNRSYVQKVAILIIDEIHLLG-EDRGPVLEVIVSRTNFISSHTS------KPVRVVGLSTALANARDLADWLGIGQMGLFNFRPSVRPVPLE 1483

[Close]

BLAST of DNA polymerase theta vs. Ensembl Sea Lamprey
Match: helq (helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-060503-421])

HSP 1 Score: 190.66 bits (483), Expect = 1.087e-49
Identity = 121/291 (41.58%), Postives = 175/291 (60.14%), Query Frame = 2

Query:  167 GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDE-HRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLS-TP------IRM--FNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYL 1000
            GI  L++WQ +C+ LN V  G KNL+YS PTS GKTLV+EI++L+ +L  ++  L ILPYV++ +EK   +  F         +  G  G M P+       + + TIEKA++LVN L+++G ++E+ L+V+DELHMLG+   RG  LE  L K+ Y SKT          TQIIGMSATL N+N + ++L AELY  D+RP+ L+E +K    IY   + +  P      IR+  +   SG++K D D I+ L  E ++  H CLVFCPTKK CE +++ + K L   +L
Sbjct:   83 GIKELYAWQHDCLSLNSVRQG-KNLIYSLPTSGGKTLVAEILMLRELLCKRRDALLILPYVAIVQEKVRSLSVFGVELEIFIEEYAGSKGRMPPRKKRKKNSLYIATIEKAHSLVNSLLEEGRMQEIGLIVVDELHMLGEGGSRGATLEQTLAKVQYTSKT----------TQIIGMSATLSNINDLQKFLNAELYTNDFRPVELREYIKLGDSIYGVNNKALCPEEQFDFIRLLSYKYSSGMLKMDPDHIVALVTE-VIPAHSCLVFCPTKKNCENVAEMICKYLAKTFL 361

HSP 2 Score: 83.9593 bits (206), Expect = 2.316e-16
Identity = 49/189 (25.93%), Postives = 92/189 (48.68%), Query Frame = 2

Query:  986 TPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLG--WSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAK 1546
            TP  +      DW  +    N     E +V   +G+ E F+ +      T  +  D+    RFY +L+LY L  + S  +   KF   +G +Q+L   AA +A  +  FC  L   W++ ++L     +++ + V  +L+ L+ ++ +   RAR  +KAG ++++ +A A  K++   + + LP + AK
Sbjct:  627 TPYDMVSQCRPDWNTYMRQFNQLDVTEQKVATFIGVPEGFIARKMAGQGTRQKTVDERVVNRFYLALVLYALFKQTSVWEAASKFGQNRGFIQNLVGSAAAFASCIMHFCQELDEFWAY-QLLFADLTQKLSYCVKSELIPLMEVAGVKEARARQLYKAGFKSLAILANADPKDLVQQI-EFLPHRQAK 813

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BLAST of DNA polymerase theta vs. Ensembl Sea Lamprey
Match: helq (helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-060503-421])

HSP 1 Score: 182.57 bits (462), Expect = 1.707e-47
Identity = 118/280 (42.14%), Postives = 167/280 (59.64%), Query Frame = 2

Query:  167 GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDE-HRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLS-TPIRMFNCPSGV-IKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELT 988
            GI  L++WQ +C+ LN V  G KNL+YS PTS GKTLV+EI++L+ +L  ++  L ILPYV++ +EK   +  F         +  G  G M P+       + + TIEKA++LVN L+++G ++E+ L+V+DELHMLG+   RG  LE  L K+ Y SKT          TQIIGMSATL N+N + ++L AELY  D+RP+ L+E +K    IY   + +  P   F+    +  K D D I+ L  E I   H CLVFCPTKK CE +++ + K L 
Sbjct:   17 GIKELYAWQHDCLSLNSVRQG-KNLIYSLPTSGGKTLVAEILMLRELLCKRRDALLILPYVAIVQEKVRSLSVFGVELEIFIEEYAGSKGRMPPRKKRKKNSLYIATIEKAHSLVNSLLEEGRMQEIGLIVVDELHMLGEGGSRGATLEQTLAKVQYTSKT----------TQIIGMSATLSNINDLQKFLNAELYTNDFRPVELREYIKLGDSIYGVNNKALCPEEQFDFIRLLSYKMDPDHIVALVTEVI-PAHSCLVFCPTKKNCENVAEMICKYLA 284

HSP 2 Score: 83.1889 bits (204), Expect = 3.234e-16
Identity = 49/189 (25.93%), Postives = 92/189 (48.68%), Query Frame = 2

Query:  986 TPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLG--WSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAK 1546
            TP  +      DW  +    N     E +V   +G+ E F+ +      T  +  D+    RFY +L+LY L  + S  +   KF   +G +Q+L   AA +A  +  FC  L   W++ ++L     +++ + V  +L+ L+ ++ +   RAR  +KAG ++++ +A A  K++   + + LP + AK
Sbjct:  551 TPYDMVSQCRPDWNTYMRQFNQLDVTEQKVATFIGVPEGFIARKMAGQGTRQKTVDERVVNRFYLALVLYALFKQTSVWEAASKFGQNRGFIQNLVGSAAAFASCIMHFCQELDEFWAY-QLLFADLTQKLSYCVKSELIPLMEVAGVKEARARQLYKAGFKSLAILANADPKDLVQQI-EFLPHRQAK 737

[Close]

BLAST of DNA polymerase theta vs. Ensembl Sea Lamprey
Match: ascc3 (activating signal cointegrator 1 complex subunit 3 [Source:NCBI gene;Acc:100332599])

HSP 1 Score: 70.8626 bits (172), Expect = 2.444e-12
Identity = 53/210 (25.24%), Postives = 107/210 (50.95%), Query Frame = 2

Query:  227 GSKNLVYSAPTSAGKTLVSXXXXXXX-XXXXXXXXXFILPYVSVSKEKM----VYFQXXXXXXXXXXXXXMGDMSPKG-GLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVC-----DYRPIPLQEMMKCDSKIYDCKDLST 823
            G  N++  APT +GKT+ +E+ + +        K ++I P  ++ +E+M    V  +   G    ++    GD++P    +A+ D+ V T EK + +         +++++LLVIDE+H+LGD+ RG +LE+++++  + S   +      +  +++G+S  L N   +A WL  +  +        RP+PL+  +      + C  ++T
Sbjct:  709 GDGNVLLGAPTGSGKTVAAELAIFRIFNAHPGAKAVYIAPLKALVRERMEDWKVRLEPEAGCAAARVVELTGDVTPDARAIASADLIVTTPEKWDGVSRSWHSRSYVKQVALLVIDEIHLLGDD-RGPVLEVIVSRTNFISSHTE------KPVRVVGLSTALANARDLADWLAIKQVILFNFRPSVRPVPLEAHIHGFPGQHYCPRMAT 911

[Close]

BLAST of DNA polymerase theta vs. Ensembl Sea Lamprey
Match: ascc3 (activating signal cointegrator 1 complex subunit 3 [Source:NCBI gene;Acc:100332599])

HSP 1 Score: 67.3958 bits (163), Expect = 2.884e-11
Identity = 51/212 (24.06%), Postives = 106/212 (50.00%), Query Frame = 2

Query:  227 GSKNLVYSAPTSAGKTLVSXXXXXXX-XXXXXXXXXFILPYVSVSKEKMVYFQXXXXX------XXXXXXXXMGDMSPKG-GLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVC-----DYRPIPLQEMMKCDSKIYDCKDLST 823
            G  N++  APT +GKT+ +E+ + +        K ++I P  ++ +E+M  ++              ++    GD++P    +A+ D+ V T EK + +         +++++LLVIDE+H+LGD+ RG +LE+++++  + S   +      +  +++G+S  L N   +A WL  +  +        RP+PL+  +      + C  ++T
Sbjct:  708 GDGNVLLGAPTGSGKTVAAELAIFRIFNAHPGAKAVYIAPLKALVRERMEDWKVRLEPEAGKECAAARVVELTGDVTPDARAIASADLIVTTPEKWDGVSRSWHSRSYVKQVALLVIDEIHLLGDD-RGPVLEVIVSRTNFISSHTE------KPVRVVGLSTALANARDLADWLAIKQVILFNFRPSVRPVPLEAHIHGFPGQHYCPRMAT 912

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BLAST of DNA polymerase theta vs. Ensembl Yeast
Match: BRR2 (RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD [Source:SGD;Acc:S000000974])

HSP 1 Score: 63.1586 bits (152), Expect = 4.100e-10
Identity = 82/309 (26.54%), Postives = 137/309 (44.34%), Query Frame = 2

Query:  113 DKDNVFLPQNVFNQYNELGITSLFSW------QSECIKLNGV--------LDGSKNLVYSAPTSAGKTLVSXXXXXXXXXX-----------XXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMS-PKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWL---KAELYVCD--YRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKK 946
            D+ ++  P      Y    ITSL  W       SE   LN +         +G  N++  APT +GKT ++ + +LK +                K+++I P  ++ +E++  FQ+    +G+K+    GD    +  +    + V T EK +       +   +E + LL+IDE+H+L D+ RG +LE ++ +  + SK  +E        +IIG+SATLPN   V ++L   K  L+  D  +RP PL +      +    K L              K   D      LE+I EG+  +VF  ++K
Sbjct:  461 DEIHIPAPSKPVIDYELKEITSLPDWCQEAFPSSETTSLNPIQSKVFHAAFEGDSNMLICAPTGSGKTNIALLTVLKALSHHYNPKTKKLNLSAFKIVYIAPLKALVQEQVREFQRRLAFLGIKVAELTGDSRLSRKQIDETQVLVSTPEKWDITTRNSNNLAIVELVRLLIIDEIHLLHDD-RGPVLESIVARTFWASKYGQEY------PRIIGLSATLPNYEDVGRFLRVPKEGLFYFDSSFRPCPLSQQFCGIKERNSLKKL--------------KAMNDACYEKVLESINEGNQIIVFVHSRK 748

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BLAST of DNA polymerase theta vs. Ensembl Yeast
Match: SLH1 (Putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses [Source:SGD;Acc:S000003503])

HSP 1 Score: 58.9214 bits (141), Expect = 9.178e-9
Identity = 68/274 (24.82%), Postives = 126/274 (45.99%), Query Frame = 2

Query:  230 SKNLVYSAPTSAGKTLVSXXXXXXXXXXXXX--------------XXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMS-PKGGLATVDIAVCTIEKANNLVNRLIDDGSL-EELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVC------DYRPIPL-QEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCL-ETILEGHGCLVFCPTKKWCETMSKNLAK 979
            ++N++  APT AGKT ++ + ++  + +                 KV+++ P  +++ E +  F K      +++    GDM   K  +    + V T EK + +  +   D  L  ++ LL+IDE+H+L  E RG ++E L+      ++T+++ + +    +IIG+SATLPN   VA +L     +        +RP PL Q+++ C  K                 S   K + D++    L E I  G+  +VF  ++K     ++N  K
Sbjct:  303 NENMLICAPTGAGKTDIALLTIINTIKQFSVVNGENEIDIQYDDFKVIYVAPLKALAAEIVDKFSKKLAPFNIQVRELTGDMQLTKAEILATQVIVTTPEKWDVVTRKANGDNDLVSKVKLLIIDEVHLL-HEDRGSVIETLV------ARTLRQVESSQSMIRIIGLSATLPNFMDVADFLGVNRQIGMFYFDQSFRPKPLEQQLLGCRGK---------------AGSRQSKENIDKVAYDKLSEMIQRGYQVMVFVHSRKETVKSARNFIK 554

HSP 2 Score: 49.2914 bits (116), Expect = 7.953e-6
Identity = 48/189 (25.40%), Postives = 97/189 (51.32%), Query Frame = 2

Query:  230 SKNLVYSAPTSAGKTLVSXXXX-XXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXM-GDMSPK-GGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAE---LY--VCDYRPIPLQ 772
            ++N    +PT +GKT+V+E+ +         KK+++I P  ++ +E++  ++K    +       + GD  P    +    I + T EK + +         ++++SL+++DE+H+L  + RG ILE++++++ Y S   K+        +++GMS  + N   +A WL  +   LY      RP+PL+
Sbjct: 1155 NENAFVGSPTGSGKTIVAELAIWHAFKTFPGKKIVYIAPMKALVRERVDDWRKKITPVTGDKVVELTGDSLPDPKDVHDATIVITTPEKFDGISRNWQTRKFVQDVSLIIMDEIHLLASD-RGPILEMIVSRMNYISSQTKQ------PVRLLGMSTAVSNAYDMAGWLGVKDHGLYNFPSSVRPVPLK 1336

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BLAST of DNA polymerase theta vs. Ensembl Yeast
Match: HFM1 (Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity [Source:SGD;Acc:S000003220])

HSP 1 Score: 52.373 bits (124), Expect = 7.509e-7
Identity = 54/174 (31.03%), Postives = 81/174 (46.55%), Query Frame = 2

Query:  461 DIAVCTIEKANNLVNRLIDDGSLEEL-SLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLK------AELYVCD--YRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHG----CLVFCPTK 943
            +I + T EK + L  R  D   L EL  L+++DE+H +  E RG  LE++LT++     TM +N       + + +SAT+PN+  +A WLK      A +   D  YR + L + +   S              FNC +   K   D I    L  I+E H      L+FCPT+
Sbjct:  236 NIIITTPEKWDLLTRRWSDYSRLFELVKLVLVDEIHTI-KEKRGASLEVILTRM----NTMCQN------IRFVALSATVPNIEDLALWLKTNNELPANILSFDESYRQVQLTKFVYGYS--------------FNCKNDFQK---DAIYNSKLIEIIEKHADNRPVLIFCPTR 381

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BLAST of DNA polymerase theta vs. Ensembl Nematostella
Match: EDO32438 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SV19])

HSP 1 Score: 151.369 bits (381), Expect = 4.045e-42
Identity = 90/151 (59.60%), Postives = 118/151 (78.15%), Query Frame = 2

Query:  179 LFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHS 631
            +F WQ++C+    VL G  NLVYSAPTSAGKT+V+E+++LKRVLE K+K L ILP+VSV++EKM Y Q+LF   G+++ GFMG  SP GG A  DIA+CTIEK N+L+NRL+++G +  L  +VIDELHM+GD +RGY+LEL LTKI Y S
Sbjct:    1 MFQWQADCLCTGNVLQGG-NLVYSAPTSAGKTMVAELLMLKRVLETKRKALLILPFVSVAREKMFYLQRLFQEAGVRVEGFMGSHSPAGGFAATDIAICTIEKGNSLLNRLMEEGKVSTLGTVVIDELHMVGDPNRGYLLELFLTKIRYLS 150

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BLAST of DNA polymerase theta vs. Ensembl Nematostella
Match: EDO43131 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZN4])

HSP 1 Score: 148.673 bits (374), Expect = 1.626e-40
Identity = 71/197 (36.04%), Postives = 121/197 (61.42%), Query Frame = 2

Query: 4730 DYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEV 5320
            D++ +ELR+L++ S DP L+  F +   +DIF K+ S+WL  P   +   +R++ K+I Y +IYG+  + L   + +E ++A+  +  F+  FPG+++F +  I+ C  NGF+ TI  R+R++P I S +   RS AERQA++  +QGSAAD+ K+AM+ + +A+  D   K+           ++L +HDE+L EV
Sbjct:    1 DFQSIELRLLANLSDDPDLLRVFNDSTSIDIFTKLTSQWLGVPPVKVDFKERERTKRIVYSVIYGVGRERLGNTLCVEPNEAKGFMESFLGKFPGINEFSRKCIEDCNTNGFVSTIFKRKRWIPHIKSRDFQIRSQAERQAVNFVVQGSAADLCKSAMIQIVHALEKDVSLKA----------RLLLQIHDELLLEV 187

[Close]

BLAST of DNA polymerase theta vs. Ensembl Nematostella
Match: EDO44748 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUT3])

HSP 1 Score: 161.384 bits (407), Expect = 2.582e-40
Identity = 112/304 (36.84%), Postives = 175/304 (57.57%), Query Frame = 2

Query:  137 QNVFNQYNELGITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGD-EHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIY---------DCKDLSTPIRMF-NCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSK----NLAKELTPV 994
            +++F  Y   GI +L+ WQ  C+KL  + +  +NL+YS PTS GKTLV+EI+++K +L   K V+ +LP+VS+ +EK   +  F    G +  +  G  G   P+       + + TIEKAN+LVN LI++  +++L L+V+DELHMLG+   RG  LE+ L K L+ +  +          QI+GMSATL N+  + ++L AE+Y  D+RP+ LQE +K D+ +Y         +  ++   +R   + P      D D ++ L LE I + H CL+FC TKK CE ++K     L +E+T V
Sbjct:    9 KDLFLAYR--GIQNLYEWQDACLKLPAIQE-KRNLIYSLPTSGGKTLVAEILMMKELLVHHKDVVLVLPFVSIVQEKVKTITQFAVELGFVVEEYAGSKGKFPPRKRRTKRALYIATIEKANSLVNSLIEEKRMDDLGLIVVDELHMLGEGGGRGATLEMCLAKTLFSTNHI----------QIVGMSATLSNIGDLQKFLMAEVYSNDFRPVELQEYVKVDNIVYKVPCSSSKSEADEIYVQVRRIGHSPDQRHIKDPDHLVPLVLEVIPQ-HSCLIFCATKKNCENVAKLMVEFLPREMTQV 298

HSP 2 Score: 70.0922 bits (170), Expect = 8.074e-12
Identity = 45/183 (24.59%), Postives = 89/183 (48.63%), Query Frame = 2

Query:  986 TPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAK----VKEITNLLRK 1522
            TP+        DW  +   V +    E +    +G+ + +L+  +   + +     +    RFY SL+LY L+   S   V+  F V +G +Q+L   AA+YA  +  F     +  +++L+ +  R++ +    +L+ L+ ++ +   RAR  +KAG   +S +A A+    V++I +L +K
Sbjct:  555 TPLDQGGTIQPDWMAYQREVATLGPEEQKAAGHIGVTDLYLLGRAYGRKLTKCPVGEEVVHRFYLSLMLYKLMQGSSMWHVSSVFQVSRGFVQNLLTSAASYASCLVRFTEAKEFWTIKLLLEAMVRKLSYTTHLELIPLMEVAGVKQARARQLYKAGYRNLSDLAWAEPAVLVQQIEHLPKK 737

[Close]

BLAST of DNA polymerase theta vs. Ensembl Nematostella
Match: EDO38599 (DNA polymerase [Source:UniProtKB/TrEMBL;Acc:A7SCG9])

HSP 1 Score: 138.272 bits (347), Expect = 1.480e-34
Identity = 79/211 (37.44%), Postives = 116/211 (54.98%), Query Frame = 2

Query: 4508 QQLSSTGRLNSTSPNLQSVPKPIQINWFKL------LHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENP 5122
            Q  ++TGR++   PNLQ+VP+  +I    +      L   +R+  +  A+    D +  S   + R+ F    G VL+ ADY QLELR+++H + D  L        DV  F  +A         S+ D  RQ+AKQI YGIIYGI A+ L EQ+ + E  A   I +F   F G+ +++KST++ CRK G++ TIT RRRYLP + S +P
Sbjct:  219 QTHTTTGRVSFNEPNLQNVPRDFEIELPSVIAESPPLGTRRRENIQKPARS---DHSGMSCAVSMRTAFVPCAGGVLLAADYSQLELRLIAHLADDSRLRKVLNGGGDV--FRMIAGSLAGLEPGSVDDKQRQRAKQICYGIIYGIGAKALGEQLELGEEDASMYIEKFKSRFSGIRRYLKSTVEQCRKTGYVTTITKRRRYLPAVNSTHP 424

[Close]

BLAST of DNA polymerase theta vs. Ensembl Nematostella
Match: EDO49146 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH22])

HSP 1 Score: 63.1586 bits (152), Expect = 1.156e-9
Identity = 58/203 (28.57%), Postives = 107/203 (52.71%), Query Frame = 2

Query:  218 VLDGSKNLVYSAPTSAGKTLVSXXXXXX----------XXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMS-PKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAE----LYVCD--YRPIPLQE 775
             L+  +NL+  APT AGKT V+ + +L+           +   + K++++ P  S+ +E ++ F K     GL +    GD +  K  +    I VCT EK + +  +  +    + + L++IDE+H+L D+ RG +LE L+ + +   +T +E        +++G+SATLPN   VA +++      L+  D  +RP+PL++
Sbjct:  492 ALNSDENLLLCAPTGAGKTNVALLTILREIGKHINLDGTINTEEFKIIYVAPMRSLVQEMVLNFSKRLSTYGLTVSELTGDHNLTKEQIHGTQIIVCTPEKWDIITRKSGERTFTQLVRLIIIDEIHLLHDD-RGPVLESLVARTIRQIETTQE------LVRLVGLSATLPNYEDVATFMRVNPAKGLFFFDNSFRPVPLEQ 687

HSP 2 Score: 53.5286 bits (127), Expect = 1.173e-6
Identity = 50/191 (26.18%), Postives = 101/191 (52.88%), Query Frame = 2

Query:  224 DGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXX-XFILPYVSVSKEKMVYFQXXXXXXXXXXXXXM-GDMSPKGGL-ATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAEL-----YVCDYRPIPLQ 772
            D S+N+   APT +GKT+ +E  +L+ + +  +   +++ P  +++++    +Q  FG    K    + G+ S    L A  ++ V T EK + L  R     +++ +SL ++DE H++G +  G ++E++ +++ Y S  ++      R  +I+ +S++L N   VAQWL         +  + RP+PL+
Sbjct: 1341 DSSENVFIGAPTGSGKTICAEFAVLRFLQQSPEGRCVYVTPIQALAEQVYADWQNKFGLQLGKNVVMLTGETSADLKLLAKGNVVVSTPEKWDVLSRRWKQRKNVQNVSLFIMDEAHLIGGD-TGPVMEIICSRMRYISSQLE------RTIRIVALSSSLANAKDVAQWLGVPSTGLFNFHPNVRPVPLE 1524

[Close]

BLAST of DNA polymerase theta vs. Ensembl Medaka
Match: ENSORLT00000006618.2 (pep primary_assembly:ASM223467v1:1:12654319:12664856:-1 gene:ENSORLG00000005243.2 transcript:ENSORLT00000006618.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 234.958 bits (598), Expect = 1.283e-61
Identity = 166/479 (34.66%), Postives = 258/479 (53.86%), Query Frame = 2

Query: 4115 GVNFSVMESQIKE--VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKN-----------STSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLL-----------HLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSL----NQIPAM-----VLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            G+ FSV E + ++  ++  +  L+  A+ ++G +F++ S  +++++LF+E+  P  G   GG  T+K               K  ++TK  L  L  LHPLPG+ILE+R +   + K + PL    ++     +    +I  I Q  ++TGR++ T PN+Q+VPK   I    ++              K+      A   G+ +   +   + R  F    G +++ ADY QLELR+L+H S+D  L+         D+F  +A++W     ES+ D  RQQAKQI YGIIYG+ A+ L EQM +EE+ A   I  F   + G++ F+K T+  C K+GF++T+ GRRRYLP I+S +P  R+HAERQA+++T+QGSAADIVK A V +   +   Y       + L    NQ  A+     +L LHDE++YE     +  +A I+K+ ME +  L V L VKVK G  W +L D  +
Sbjct: 1208 GLGFSVEECERQKHVMQAKLSALESEAYTLAGHSFSLTSVDDIAQVLFLELHLPPNGEI-GGIRTKKTLGYTRRGGGRVRFGKQFSTTKDVLEKLRPLHPLPGVILEWRRITNALTKVVFPLQ---REKQYHPTLKMDRIYPIAQTHTATGRVSFTEPNIQNVPKDFDIKMPTMVDESPPSQNAPHRPGKKRRPLTPALTRGLAEQGPAFSVSMRHAFVPFSGGMILAADYSQLELRVLAHLSKDQRLLQVLNG--GADVFRCIAAEWKNVDPESVQDNLRQQAKQICYGIIYGMGAKSLGEQMGVEENDAACYIESFKARYKGINAFLKQTVKNCIKDGFVQTLMGRRRYLPGILSSSPHIRAHAERQAVNTTVQGSAADIVKLATVNIQKRLQKTYPAAPPSHQHLHTARNQRRAVRGAYFILQLHDELIYETTQEDLIQVAQIVKREMESAVKLYVKLKVKVKMGCSWGDLQDLDI 1680

HSP 2 Score: 139.813 bits (351), Expect = 1.711e-32
Identity = 77/202 (38.12%), Postives = 126/202 (62.38%), Query Frame = 2

Query: 1292 AGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDR-ILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSN----DKEISSRSTINCEDKENFNPSDL 1882
            +GMVT+FC RLGW ++E+L++ +Q R+ FGV  +L+DLVR+SL+NA RAR  +  GL T++ +A A V ++   LR S+PF+S+K      E++     S R +    G++L  +EAA+E++SE+++LL+ DL  +G++W+P  L       +E S +  P  D ++S +  TSN    D+E   R  +  ED +N +P+ L
Sbjct:   26 SGMVTVFCKRLGWHNMEMLLSQYQTRLSFGVQRELLDLVRVSLLNATRARALYAQGLCTVAELARATVADVEKALRNSVPFKSSKRAVDESEVEAAERRSLRCVWVAGGRALTEQEAAVEIVSEARLLLREDLAQLGVQWDPAALP------AEASVACSP--DGHSSRDSDTSNQLKEDREGGKRMVVG-EDGKNEDPNGL 218

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BLAST of DNA polymerase theta vs. Ensembl Medaka
Match: poln (DNA polymerase nu [Source:NCBI gene;Acc:101172689])

HSP 1 Score: 181.415 bits (459), Expect = 2.046e-45
Identity = 108/316 (34.18%), Postives = 167/316 (52.85%), Query Frame = 2

Query: 4523 TGRLNSTSPNLQSVPK-PIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEK-------SYDLKVSLPVKVKTGTVWSELNDF 5446
            TGR+++  PN Q++PK P+QI          + LF +   E       + V  + R+ F    G+  + AD+ Q+ELR+L+HFS DP L+  F   P  D+F  +A++W    ME ++  DR+ AK+I Y +IYG   + LS  + +   +A Q  + F+  +  V  FI+ TI    K G++ +I GRRR LPDI S +   R  +ERQA++  +QGSAAD+ K AM+ + N ++           S +    +V  LHDE+LYEV  + +   A ++K  ME           LKV L V V +G  W  +++F
Sbjct:  937 TGRISAKHPNFQALPKQPLQIT---------KKLFVHGGAE-------EVVTVHPRAMFVPHKGWTFLAADFCQVELRLLAHFSSDPDLLHLFTI-PQADVFTMLAAQWKGLNMEDVSSEDREHAKRIIYSVIYGAGRERLSGILGVSAEQASQFQHRFLQTYRDVQTFIQKTIQQSHKQGYVLSIMGRRRNLPDINSPDWGVRMQSERQAVNFVVQGSAADLCKMAMIRIFNLVST----------SSSLTARLVAQLHDELLYEVEDSQLEPFATLVKSTMESLQHIDHLGVHLKVPLKVAVSSGKTWGSMSEF 1225

[Close]

BLAST of DNA polymerase theta vs. Ensembl Medaka
Match: poln (DNA polymerase nu [Source:NCBI gene;Acc:101172689])

HSP 1 Score: 181.03 bits (458), Expect = 3.001e-45
Identity = 108/316 (34.18%), Postives = 167/316 (52.85%), Query Frame = 2

Query: 4523 TGRLNSTSPNLQSVPK-PIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEK-------SYDLKVSLPVKVKTGTVWSELNDF 5446
            TGR+++  PN Q++PK P+QI          + LF +   E       + V  + R+ F    G+  + AD+ Q+ELR+L+HFS DP L+  F   P  D+F  +A++W    ME ++  DR+ AK+I Y +IYG   + LS  + +   +A Q  + F+  +  V  FI+ TI    K G++ +I GRRR LPDI S +   R  +ERQA++  +QGSAAD+ K AM+ + N ++           S +    +V  LHDE+LYEV  + +   A ++K  ME           LKV L V V +G  W  +++F
Sbjct:  981 TGRISAKHPNFQALPKQPLQIT---------KKLFVHGGAE-------EVVTVHPRAMFVPHKGWTFLAADFCQVELRLLAHFSSDPDLLHLFTI-PQADVFTMLAAQWKGLNMEDVSSEDREHAKRIIYSVIYGAGRERLSGILGVSAEQASQFQHRFLQTYRDVQTFIQKTIQQSHKQGYVLSIMGRRRNLPDINSPDWGVRMQSERQAVNFVVQGSAADLCKMAMIRIFNLVST----------SSSLTARLVAQLHDELLYEVEDSQLEPFATLVKSTMESLQHIDHLGVHLKVPLKVAVSSGKTWGSMSEF 1269

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BLAST of DNA polymerase theta vs. Ensembl Medaka
Match: helq (helicase, POLQ like [Source:NCBI gene;Acc:101166357])

HSP 1 Score: 174.481 bits (441), Expect = 1.403e-43
Identity = 117/305 (38.36%), Postives = 170/305 (55.74%), Query Frame = 2

Query:  131 LPQNVFNQYNEL-GITSLFSWQSECIKLNGVLDGSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEK---MVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLS------TPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTA 1015
            LP  V    + L GI  L+ WQ  C+ L+ V    +NL+YS PTS GKTLV+EI++L+ +L  +K  L +LPY+S+ +EK   +         +  +  G  G   P        + V TIEKA++LVN LI+ G LE L LLV+DELHMLG+  RG ++E+ + K+ + SK           TQ+IGMSATL N+  +  +L+AELY  D+RP+ L+E +K +  IY+           + +  F   S + KTD D I+ L  E ++  H CL+FCPTKK CE ++  + K L   +L    A
Sbjct:  210 LPSKVKELMHRLRGIQKLYDWQEACLNLDCV-QQRRNLIYSLPTSGGKTLVAEILILRELLCRRKDCLLVLPYISLVQEKVRGLASLGLELDFLVEEYAGSRGRFPPVRRRNRTSLYVATIEKAHSLVNSLIETGRLENLGLLVVDELHMLGEGSRGAVMEMTVAKVQHLSKN----------TQVIGMSATLGNIQDLQAFLRAELYSSDFRPVQLKEFVKVNDSIYEVDPTQESGFRFSRLLPFKYSSSMQKTDPDHIIALVTE-VIPAHSCLIFCPTKKNCENVAAMICKYLKGDFLRHREA 502

HSP 2 Score: 63.1586 bits (152), Expect = 2.870e-9
Identity = 45/171 (26.32%), Postives = 85/171 (49.71%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLG--WSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGA 1489
            +TP  L    + +W  +     S S AE ++   +G+ E F+ + + +G+T  +  D  + +R Y +L+L  L+ E S   V E+F + +G +Q+L   AA +      F   L   W     L+ +  +R+ + V  +LV L+ ++ +   RA+  + AG  T++ +A A
Sbjct:  758 VTPYELVPQCSPNWMIYLRQFTSLSAAEQKMSAAIGVPESFVARKA-AGQTVKKGVDAAQAQRLYLALVLLCLLKETSVWGVAERFQLSRGFVQTLLSSAAAFCSCALHFAEELEELWP-FRSLLAALTQRLTYCVKAELVPLMEVAGVMEARAKQLYSAGYRTLTHLANA 926

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BLAST of DNA polymerase theta vs. Ensembl Medaka
Match: hfm1 (helicase for meiosis 1 [Source:ZFIN;Acc:ZDB-GENE-061207-43])

HSP 1 Score: 70.0922 bits (170), Expect = 1.751e-11
Identity = 60/220 (27.27%), Postives = 108/220 (49.09%), Query Frame = 2

Query:  461 DIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKI-LYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDY-------RPIPLQEMM---KCDSKIYDCK-DLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMIL 1084
            +I + T EK ++L  +  D+  L+ + L +IDE+H++ D  RG  LE++++++   HS    +N       + + +SAT+PN++ +A+WL  E     Y       RP+ L++++    C     + K DLS   +M N    +I+T  DQ               LVFC T+K  +  +  LAK+     +  N +I+        NS  +++LR++ L
Sbjct:  111 NIILTTPEKWDSLTRKWRDNCLLQLVRLFLIDEVHVVKDATRGATLEVVVSRMKAVHSFRTSQNPEAGLSMRFVAVSATIPNVSDIAEWLSNEGEPATYLNMNESHRPVKLRKVVLGFPCSPNQTEFKFDLSLSYKMAN----IIQTYSDQ------------KPALVFCSTRKGAQQSAAILAKD-----VRFNLSIEHKQLTKYANSVLDSKLRLVPL 309

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BLAST of DNA polymerase theta vs. Planmine SMEST
Match: SMESG000034022.1 (SMESG000034022.1)

HSP 1 Score: 3028.81 bits (7851), Expect = 0.000e+0
Identity = 1588/1590 (99.87%), Postives = 1588/1590 (99.87%), Query Frame = 2

Query:  683 MSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIXXXXXXXXXXXXXXXXXXXXXXXFLNLDSSGSNSYETCETSICPLHETQDTKNQACHXXXXXXXXXXXXXXXXHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFEXXXXXXXXXXXXQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILXXXXXXXXXXXXXXXXXXXXXALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKSSSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVNSLYDQTIVEVCKTRNTWNNFLSELESWKKVLIGDFSKKKIISITLAWKFDCNNEIELLGISIFPEXXXXVYYLNLLNPIGSRVNVSLKRRSEFLVDLLSLPHFLFVSFDWIFVLSLLERKLNQHFMKHDNLIDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIGDRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            MSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIDKKSDKSKRLSGGSSSSITKEISFLNLDSSGSNSYETCETSICPLHETQDTKNQACHIKIDKKNPKKSKILSKHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFELLMNDDLNTLNNQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILNTNRKTNNRKTKNSSKNESSKALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKSSSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVNSLYDQTIVEVCKTRNTWNNFLSELESWKKVLIGDFSKKKIISITLAWKFDCNNEIELLGISIFPESSSSVYYLNLLNPIGSRVNVSLKRRSEFLVDLLSLPHFLFVSFDWIFV SLLERKLNQHFMKHDNLIDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIGDRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNI YIIDQAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKNLNHLLSLHPLPGLILEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV
Sbjct:    1 MSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIDKKSDKSKRLSGGSSSSITKEISFLNLDSSGSNSYETCETSICPLHETQDTKNQACHIKIDKKNPKKSKILSKHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFELLMNDDLNTLNNQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILNTNRKTNNRKTKNSSKNESSKALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKSSSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVNSLYDQTIVEVCKTRNTWNNFLSELESWKKVLIGDFSKKKIISITLAWKFDCNNEIELLGISIFPESSSSVYYLNLLNPIGSRVNVSLKRRSEFLVDLLSLPHFLFVSFDWIFVFSLLERKLNQHFMKHDNLIDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIGDRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNIGYIIDQAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKNLNHLLSLHPLPGLILEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 1590

[Close]

BLAST of DNA polymerase theta vs. Planmine SMEST
Match: SMESG000034022.1 (SMESG000034022.1)

HSP 1 Score: 2811.56 bits (7287), Expect = 0.000e+0
Identity = 1488/1490 (99.87%), Postives = 1488/1490 (99.87%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIXXXXXXXXXXXXXXXXXXXXXXXFLNLDSSGSNSYETCETSICPLHETQDTKNQACHXXXXXXXXXXXXXXXXHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFEXXXXXXXXXXXXQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILXXXXXXXXXXXXXXXXXXXXXALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKSSSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVNSLYDQTIVEVCKTRNTWNNFLSELESWKKVLIGDFSKKKIISITLAWKFDCNNEIELLGISIFPEXXXXVYYLNLLNPIGSRVNVSLKRRSEFLVDLLSLPHFLFVSFDWIFVLSLLERKLNQHFMKHDNLIDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIGDRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNISYIIDQAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
            LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIDKKSDKSKRLSGGSSSSITKEISFLNLDSSGSNSYETCETSICPLHETQDTKNQACHIKIDKKNPKKSKILSKHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFELLMNDDLNTLNNQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILNTNRKTNNRKTKNSSKNESSKALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKSSSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVNSLYDQTIVEVCKTRNTWNNFLSELESWKKVLIGDFSKKKIISITLAWKFDCNNEIELLGISIFPESSSSVYYLNLLNPIGSRVNVSLKRRSEFLVDLLSLPHFLFVSFDWIFV SLLERKLNQHFMKHDNLIDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIGDRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNI YIIDQAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKNLNHLLSLHPLPGLILEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV
Sbjct:  611 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIDKKSDKSKRLSGGSSSSITKEISFLNLDSSGSNSYETCETSICPLHETQDTKNQACHIKIDKKNPKKSKILSKHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFELLMNDDLNTLNNQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILNTNRKTNNRKTKNSSKNESSKALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKSSSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVNSLYDQTIVEVCKTRNTWNNFLSELESWKKVLIGDFSKKKIISITLAWKFDCNNEIELLGISIFPESSSSVYYLNLLNPIGSRVNVSLKRRSEFLVDLLSLPHFLFVSFDWIFVFSLLERKLNQHFMKHDNLIDVLLMDWMLNSENCCHTFLDICNKYNIRLNNKLKVPINNKLVDIVKIGDRDLTPSNVIATDKDAANQALVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNIGYIIDQAPGFGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKNLNHLLSLHPLPGLILEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 2100

HSP 2 Score: 464.922 bits (1195), Expect = 6.512e-134
Identity = 256/265 (96.60%), Postives = 258/265 (97.36%), Query Frame = 2

Query:  227 GSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTAID 1021
            GSKNLVYSAPTSAGKTLVSEIILLKRVLELKKKVLFILPYVSVSKEKMVYFQKLFGGIGLKIGGFMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKE+  + L MN   D
Sbjct:   51 GSKNLVYSAPTSAGKTLVSEIILLKRVLELKKKVLFILPYVSVSKEKMVYFQKLFGGIGLKIGGFMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEI--LRLCMNAEKD 313

[Close]

BLAST of DNA polymerase theta vs. Planmine SMEST
Match: SMESG000034022.1 (SMESG000034022.1)

HSP 1 Score: 1431 bits (3703), Expect = 0.000e+0
Identity = 799/799 (100.00%), Postives = 799/799 (100.00%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIXXXXXXXXXXXXXXXXXXXXXXXFLNLDSSGSNSYETCETSICPLHETQDTKNQACHXXXXXXXXXXXXXXXXHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFEXXXXXXXXXXXXQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILXXXXXXXXXXXXXXXXXXXXXALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKSSSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVN 3379
            LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIDKKSDKSKRLSGGSSSSITKEISFLNLDSSGSNSYETCETSICPLHETQDTKNQACHIKIDKKNPKKSKILSKHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFELLMNDDLNTLNNQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILNTNRKTNNRKTKNSSKNESSKALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKSSSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVN
Sbjct:  601 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIDKKSDKSKRLSGGSSSSITKEISFLNLDSSGSNSYETCETSICPLHETQDTKNQACHIKIDKKNPKKSKILSKHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFELLMNDDLNTLNNQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILNTNRKTNNRKTKNSSKNESSKALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKSSSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVN 1399

HSP 2 Score: 464.537 bits (1194), Expect = 3.281e-137
Identity = 256/265 (96.60%), Postives = 258/265 (97.36%), Query Frame = 2

Query:  227 GSKNLVYSAPTSAGKTLVSXXXXXXXXXXXXXXXXFILPYVSVSKEKMVYFQXXXXXXXXXXXXXMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTAID 1021
            GSKNLVYSAPTSAGKTLVSEIILLKRVLELKKKVLFILPYVSVSKEKMVYFQKLFGGIGLKIGGFMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKE+  + L MN   D
Sbjct:   41 GSKNLVYSAPTSAGKTLVSEIILLKRVLELKKKVLFILPYVSVSKEKMVYFQKLFGGIGLKIGGFMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSLEELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQIIGMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEI--LRLCMNAEKD 303

[Close]

BLAST of DNA polymerase theta vs. Planmine SMEST
Match: SMESG000034022.1 (SMESG000034022.1)

HSP 1 Score: 1349.73 bits (3492), Expect = 0.000e+0
Identity = 742/742 (100.00%), Postives = 742/742 (100.00%), Query Frame = 2

Query:  983 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIXXXXXXXXXXXXXXXXXXXXXXXFLNLDSSGSNSYETCETSICPLHETQDTKNQACHXXXXXXXXXXXXXXXXHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFEXXXXXXXXXXXXQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILXXXXXXXXXXXXXXXXXXXXXALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEY 3208
            LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIDKKSDKSKRLSGGSSSSITKEISFLNLDSSGSNSYETCETSICPLHETQDTKNQACHIKIDKKNPKKSKILSKHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFELLMNDDLNTLNNQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILNTNRKTNNRKTKNSSKNESSKALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEY
Sbjct:  409 LTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSGRTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQAATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNACRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYNSNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVKIDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSDLSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTIDKKSDKSKRLSGGSSSSITKEISFLNLDSSGSNSYETCETSICPLHETQDTKNQACHIKIDKKNPKKSKILSKHLIDSKTKTNKNVSGNNTQRNVKHSIKSQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFRTEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPVTADPFDSPLRTNSNENGASHSHIMKDGDSFELLMNDDLNTLNNQSVKSNDLSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMSPLTTNEEDSEILVPNSQPMFKTPILNTNRKTNNRKTKNSSKNESSKALFDSVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEY 1150

HSP 2 Score: 885.174 bits (2286), Expect = 0.000e+0
Identity = 446/447 (99.78%), Postives = 446/447 (99.78%), Query Frame = 2

Query: 4112 FGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 5452
             GVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKNLNHLLSLHPLPGLILEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV
Sbjct: 1154 IGVNFSVMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQGIFNGGKITRKNSTSKITASTKKNLNHLLSLHPLPGLILEYRHLGMLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQINWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV 1600

HSP 3 Score: 228.024 bits (580), Expect = 1.085e-59
Identity = 104/113 (92.04%), Postives = 106/113 (93.81%), Query Frame = 2

Query:  683 MSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKELTPVYLSMNTAID 1021
            MSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKE+  + L MN   D
Sbjct:    1 MSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPIRMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAKEI--LRLCMNAEKD 111

[Close]

BLAST of DNA polymerase theta vs. Planmine SMEST
Match: SMESG000032684.1 (SMESG000032684.1)

HSP 1 Score: 116.701 bits (291), Expect = 5.827e-26
Identity = 121/462 (26.19%), Postives = 199/462 (43.07%), Query Frame = 2

Query: 4154 VKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFP------------VQGIFNGGKITRKNSTSKITASTKKXXXXXXXXXXXXXXXXEYRHLG---MLVEKTLNPLFEACKKVVIANSTTNPKIKCIYQQLSS-TGRLNSTSPNLQSVPKPIQINWFKLL-----HLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTADYRQLELRILSHFSRDPALIGFF--INQPDVDIFIKMASKWLKKPMESITDVDRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFIKSTIDICRKNGFIETITGRRRYLP-----DIISENPFCRSHAERQAIHSTIQGSAADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLNYMHNMAVILKQCME------------KSYDLKVSLPVKVKTG 5419
            +K  +  L++ A  ++G T  + SP  + ++++ +++              +  + N G  T +   SK++A            HPLP L+++YRH+     +   + + L +  KK           I   ++Q SS TGR+  + PNLQ+ P+               H+D+  L                   N +S F +S     V+AD+ Q+ELR+ +H S D  LI  F   ++   D+F  MA   L   M +  +  RQ  K++ Y  +YGI ++GL+E +SI   +A+ MIN      PG+  F    ++      ++ TI GRRRY P        +      S  +RQ +   IQGSAADI K AM+     I   Y+              ++L  HDE+++ V    + +M  ++ + M              S DL+V L VKV  G
Sbjct:  295 IKNELKALERKAIEIAGSTLCLTSPSHLREVIYRQLKLQDKLGAEQRDELGISDLINAGS-TNELMLSKLSA-----------FHPLPVLVMQYRHMSKTKSIYVDSFSMLIDPVKK----------SISGTWEQHSSVTGRIYCSKPNLQAFPRDSSPCSSSSSASPAAHVDQLSL-------------------NVKSIFLSSSHHSYVSADFSQIELRLFAHLSNDSRLIQLFQSADRNQEDLFAIMAHN-LGLQMSAGCNA-RQITKRVIYACLYGIGSKGLAEMLSISPDRAKPMINTVKDYLPGLDAFASHCLETVGSTNYLSTIVGRRRYFPLERIGSGAAGGAVDLSQLKRQMMSYVIQGSAADICKVAMINCQRGIG--YRGIG---------ARLILSRHDELVWRVSNEDLIDMIDLIYREMNVSSLQYPCGTRTASIDLRVPLKVKVSKG 702

The following BLAST results are available for this feature:

BLAST of DNA polymerase theta vs. Ensembl Human
BLAST of DNA polymerase theta vs. Ensembl Celegans
BLAST of DNA polymerase theta vs. Ensembl Fly
BLAST of DNA polymerase theta vs. Ensembl Zebrafish
BLAST of DNA polymerase theta vs. Ensembl Xenopus
BLAST of DNA polymerase theta vs. Ensembl Mouse
BLAST of DNA polymerase theta vs. UniProt/SwissProt
BLAST of DNA polymerase theta vs. TrEMBL
BLAST of DNA polymerase theta vs. Ensembl Cavefish
BLAST of DNA polymerase theta vs. Ensembl Sea Lamprey
BLAST of DNA polymerase theta vs. Ensembl Yeast
BLAST of DNA polymerase theta vs. Ensembl Nematostella
BLAST of DNA polymerase theta vs. Ensembl Medaka
BLAST of DNA polymerase theta vs. Planmine SMEST

BLAST of DNA polymerase theta vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
POLQ	6.023e-73	52.22	DNA polymerase theta [Source:HGNC Symbol;Acc:HGNC:...	[more]
POLQ	9.229e-73	52.22	DNA polymerase theta [Source:HGNC Symbol;Acc:HGNC:...	[more]
POLN	6.411e-47	30.30	DNA polymerase nu [Source:HGNC Symbol;Acc:HGNC:188...	[more]
POLN	3.894e-46	27.66	DNA polymerase nu [Source:HGNC Symbol;Acc:HGNC:188...	[more]
POLN	3.894e-46	27.66	DNA polymerase nu [Source:HGNC Symbol;Acc:HGNC:188...	[more]

BLAST of DNA polymerase theta vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
polq-1	7.697e-37	30.09	DNA polymerase theta [Source:UniProtKB/Swiss-Prot...	[more]
helq-1	2.347e-36	34.83	HELicase Q homolog [Source:UniProtKB/TrEMBL;Acc:Q...	[more]
snrp-200	2.961e-11	31.36	Putative U5 small nuclear ribonucleoprotein 200 kD...	[more]
helq-1	3.789e-10	28.13	HELicase Q homolog [Source:UniProtKB/TrEMBL;Acc:Q...	[more]
Y54E2A.4	9.343e-9	29.25	pep chromosome:WBcel235:II:14754622:14778149:1 gen...	[more]

BLAST of DNA polymerase theta vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4


Match Name	E-value	Identity	Description
DNApol-theta	4.527e-62	46.34	gene:FBgn0002905 transcript:FBtr0082662	[more]
mus301	1.066e-37	36.04	gene:FBgn0002899 transcript:FBtr0076689	[more]
l(3)72Ab	4.559e-11	28.18	gene:FBgn0263599 transcript:FBtr0075527	[more]
obe	4.049e-9	26.57	gene:FBgn0038344 transcript:FBtr0083147	[more]

BLAST of DNA polymerase theta vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
polq	5.040e-76	52.28	polymerase (DNA directed), theta [Source:ZFIN;Acc:...	[more]
polq	1.538e-75	53.13	polymerase (DNA directed), theta [Source:ZFIN;Acc:...	[more]
poln	9.239e-47	30.54	polymerase (DNA directed) nu [Source:ZFIN;Acc:ZDB-...	[more]
poln	1.511e-46	30.54	polymerase (DNA directed) nu [Source:ZFIN;Acc:ZDB-...	[more]
helq	1.664e-41	38.91	helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-0605...	[more]

BLAST of DNA polymerase theta vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
polq	9.047e-74	51.36	polymerase (DNA directed), theta [Source:NCBI gene...	[more]
polq	1.302e-73	49.83	polymerase (DNA directed), theta [Source:NCBI gene...	[more]
polq	1.286e-65	46.42	polymerase (DNA directed), theta [Source:NCBI gene...	[more]
polq	1.405e-65	34.10	polymerase (DNA directed), theta [Source:NCBI gene...	[more]
polq	1.470e-65	34.10	polymerase (DNA directed), theta [Source:NCBI gene...	[more]

BLAST of DNA polymerase theta vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Polq	2.277e-79	35.79	polymerase (DNA directed), theta [Source:MGI Symbo...	[more]
Polq	9.599e-75	53.92	polymerase (DNA directed), theta [Source:MGI Symbo...	[more]
Poln	9.515e-45	30.47	DNA polymerase N [Source:MGI Symbol;Acc:MGI:267561...	[more]
Helq	5.278e-44	41.00	helicase, POLQ-like [Source:MGI Symbol;Acc:MGI:217...	[more]
Helq	1.251e-43	40.86	helicase, POLQ-like [Source:MGI Symbol;Acc:MGI:217...	[more]

BLAST of DNA polymerase theta vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8CGS6\|DPOLQ_MOUSE	6.715e-74	53.92	DNA polymerase theta OS=Mus musculus OX=10090 GN=P...	[more]
sp\|O75417\|DPOLQ_HUMAN	2.892e-72	52.22	DNA polymerase theta OS=Homo sapiens OX=9606 GN=PO...	[more]
sp\|O18475\|DPOLQ_DROME	4.538e-61	46.34	DNA polymerase theta OS=Drosophila melanogaster OX...	[more]
sp\|Q588V7\|TEB_ARATH	1.529e-56	40.18	Helicase and polymerase-containing protein TEBICHI...	[more]
sp\|Q9CDS1\|DPO1_LACLA	2.788e-52	31.76	DNA polymerase I OS=Lactococcus lactis subsp. lact...	[more]

BLAST of DNA polymerase theta vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A2P8Y3P5	7.007e-102	41.70	Helicase ATP-binding domain-containing protein OS=...	[more]
K1QA60	4.294e-78	45.10	DNA polymerase theta OS=Crassostrea gigas OX=29159...	[more]
A0A1S3FF85	1.864e-76	35.96	DNA polymerase theta OS=Dipodomys ordii OX=10020 G...	[more]
A0A2G8JBX8	3.140e-76	52.10	Putative DNA polymerase theta-like OS=Stichopus ja...	[more]
W5KBV8	7.182e-76	53.42	Polymerase (DNA directed), theta OS=Astyanax mexic...	[more]

BLAST of DNA polymerase theta vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
polq	2.720e-79	53.42	DNA polymerase theta [Source:NCBI gene;Acc:1030397...	[more]
poln	3.197e-45	31.85	polymerase (DNA directed) nu [Source:ZFIN;Acc:ZDB-...	[more]
helq	4.013e-42	38.49	helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-0605...	[more]
helq	4.827e-22	42.95	helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-0605...	[more]
ascc3	8.017e-11	25.93	activating signal cointegrator 1 complex subunit 3...	[more]

BLAST of DNA polymerase theta vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
helq	1.087e-49	41.58	helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-0605...	[more]
helq	1.707e-47	42.14	helicase, POLQ like [Source:ZFIN;Acc:ZDB-GENE-0605...	[more]
ascc3	2.444e-12	25.24	activating signal cointegrator 1 complex subunit 3...	[more]
ascc3	2.884e-11	24.06	activating signal cointegrator 1 complex subunit 3...	[more]

BLAST of DNA polymerase theta vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
BRR2	4.100e-10	26.54	RNA-dependent ATPase RNA helicase (DEIH box); requ...	[more]
SLH1	9.178e-9	24.82	Putative RNA helicase related to Ski2p; involved i...	[more]
HFM1	7.509e-7	31.03	Meiosis specific DNA helicase; involved in the con...	[more]

BLAST of DNA polymerase theta vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO32438	4.045e-42	59.60	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43131	1.626e-40	36.04	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44748	2.582e-40	36.84	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38599	1.480e-34	37.44	DNA polymerase [Source:UniProtKB/TrEMBL;Acc:A7SCG...	[more]
EDO49146	1.156e-9	28.57	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of DNA polymerase theta vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000006618.2	1.283e-61	34.66	pep primary_assembly:ASM223467v1:1:12654319:126648...	[more]
poln	2.046e-45	34.18	DNA polymerase nu [Source:NCBI gene;Acc:101172689]	[more]
poln	3.001e-45	34.18	DNA polymerase nu [Source:NCBI gene;Acc:101172689]	[more]
helq	1.403e-43	38.36	helicase, POLQ like [Source:NCBI gene;Acc:10116635...	[more]
hfm1	1.751e-11	27.27	helicase for meiosis 1 [Source:ZFIN;Acc:ZDB-GENE-0...	[more]

BLAST of DNA polymerase theta vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000034022.1	0.000e+0	99.87	SMESG000034022.1	[more]
SMESG000034022.1	6.512e-134	99.87	SMESG000034022.1	[more]
SMESG000034022.1	3.281e-137	100.00	SMESG000034022.1	[more]
SMESG000034022.1	1.085e-59	100.00	SMESG000034022.1	[more]
SMESG000032684.1	5.827e-26	26.19	SMESG000032684.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30017838 ID=SMED30017838|Name=DNA polymerase theta|organism=Schmidtea mediterranea sexual|type=transcript|length=5539bp
GTTTGATTTATTTTAATTGAAACGCATCAATTATTTGTTTTCAGGATAAT
TTATTGTTTATTATTATTTTTTTATTTCAATGAATTTTTTAATTGGCGAT
GAAATTATAATTGACAAGGATAATGTTTTTTTACCTCAAAATGTTTTCAA
TCAGTATAATGAACTTGGAATAACTTCTCTTTTCAGTTGGCAATCAGAAT
GTATAAAATTGAACGGTGTTCTTGATGGGAGTAAGAATCTAGTGTATTCC
GCTCCGACTAGTGCTGGTAAAACACTAGTATCAGAAATAATTTTATTGAA
AAGAGTTCTTGAATTGAAAAAAAAAGTTCTTTTTATATTGCCTTATGTGT
CGGTTTCTAAAGAAAAAATGGTCTATTTTCAAAAGTTATTTGGCGGTATT
GGATTGAAAATTGGTGGATTCATGGGAGACATGAGTCCGAAAGGTGGCCT
TGCAACGGTTGATATTGCTGTTTGCACTATTGAAAAGGCGAATAATTTGG
TAAATAGACTGATCGATGATGGATCTTTGGAAGAGCTTTCATTGCTTGTT
ATCGATGAATTGCACATGCTCGGAGATGAGCACCGCGGATATATTCTTGA
ATTGCTTCTCACCAAAATTCTTTATCATAGCAAAACAATGAAAGAAAACG
ATCCAAATTACAGAGAAACACAAATTATTGGAATGAGCGCAACTCTACCG
AATCTTAACGTTGTTGCTCAGTGGTTGAAAGCTGAATTGTACGTTTGTGA
TTACCGACCTATCCCGTTGCAGGAAATGATGAAATGCGACTCTAAAATTT
ACGATTGCAAAGACCTATCGACACCGATACGAATGTTTAATTGTCCATCT
GGAGTCATTAAAACTGATGAAGATCAAATTTTAGGATTGTGTTTGGAGAC
AATTTTAGAAGGACATGGATGCTTGGTGTTTTGTCCTACTAAAAAATGGT
GTGAGACAATGAGTAAAAATCTTGCAAAAGAGCTCACTCCAGTTTATCTG
TCAATGAATACTGCGATAGATTGGACGTGTTTTTATAACGTTGTGAATTC
TTTCTCAGAAGCTGAACTTCGTGTTATGATACTTGTTGGTATCGAAGAGA
AATTTTTAATTAAGTACAGTGTTAGTGGCAGAACCTCTACAAGACATTCT
GACGATCCTAAATATCGAAGATTTTATTCCTCACTTATTTTATATCATTT
GGTTAATGAATTTTCATTCCAACAAGTCACCGAAAAGTTCAACGTTGAAA
AGGGAAGCTTACAGTCATTGCAAATGCAAGCTGCCACATATGCAGGAATG
GTTACCATTTTTTGTAATCGTCTTGGTTGGAGTCATCTTGAAGTTCTTAT
GACTAGTTTTCAGAGGCGTATGATTTTCGGAGTTTCTGGAGACTTGGTCG
ATTTAGTTCGTTTATCTCTGATGAATGCTTGTAGAGCAAGAATTTTTTTT
AAAGCTGGTTTAGAAACTATATCTTCAATCGCTGGAGCTAAGGTCAAGGA
AATTACAAATCTTTTGAGAAAATCATTACCATTTCAGAGTGCTAAAGTCG
GGGATCATATTGAAGAAATGAAATATAATTCGAATAATTCTGATCGTATA
CTTGGACCTAATGGTAAATCGTTGAAATTAGAGGAAGCAGCTATGGAAAT
GATCTCAGAATCTCAAATGCTTTTAAAAAGAGATTTACAATTAATGGGAA
TTGAATGGAACCCTCCAACTTTAGTTAAAATTGATGAAAACATCTCTGAA
GTTTCTGATTCAAATATTCCTCAAATCGATATCAATAATTCTTTAAATAA
AAGCACTTCTAATGACAAAGAAATCTCATCAAGATCCACAATTAATTGTG
AAGATAAAGAGAATTTTAATCCTTCCGATTTATCGCCATATAATGATACT
ACAAAGACAAAATGTAAAATCGCAGAAAATGTAGATATTAATTTGTCGAG
AGACAAGACAAAACAATTTCACGAATATACGTTGAGATCAAGATGTGAAC
CTCGAATAATGAGTTCTGTGGATACCATTGATAAAAAAAGTGATAAATCA
AAAAGATTATCTGGAGGAAGCTCATCATCCATTACTAAGGAAATAAGTTT
TTTGAATTTAGATTCCTCAGGTTCAAACTCATATGAAACATGTGAAACGA
GTATTTGTCCATTGCATGAAACACAGGATACAAAAAATCAGGCCTGTCAC
ATAAAAATTGACAAAAAAAACCCCAAAAAATCGAAAATCTTAAGTAAACA
TTTGATTGACTCAAAAACAAAGACAAACAAAAATGTTTCTGGGAATAATA
CACAACGAAATGTCAAACATTCCATCAAATCGCAATCACTTATGCAAATT
CAAAACTCTAATTGCGACCTTAATAATACTTTAAAAGATCATTCTCATGA
ATCTAGTAATATAAAAAAGGAAGTTATGGACAAAATGAGATCTTCTATCG
AATCCAAAAATGTAATTCCTCCATTTCGAACCGAATATGGAAATACTCGT
GAAATAAATAATTCTGTCGAACCTTCCATTATCATGAAATCGGATGGAAA
AGGTGACTCTAATAAAATGGATGATTGTTTTAATGTGGAAGATCTCAGTT
TTTCAGATGATTCAATAAAGACTCCGGTAACAGCAGATCCATTTGATAGT
CCATTAAGAACGAATTCAAATGAGAATGGCGCATCTCATTCGCACATTAT
GAAGGATGGTGATTCCTTTGAGTTATTGATGAATGACGACTTGAACACTT
TAAATAATCAATCAGTCAAATCAAATGATTTATCATTCCCATCTATAATT
GATAACAAAAATACCACTGAAATCAGTCCGAATTCATTGAAAAGATCTCC
AATTGAAATGTCTACTCCTATCGGGAAAAAAAATAATAAAAAATTAAGAT
TTGAGAATTTATTTGATCAGAAAATGTCTCCTCTGACAACAAATGAGGAG
GACAGTGAAATATTGGTTCCCAACAGTCAGCCCATGTTCAAAACCCCGAT
ATTAAATACAAATCGAAAAACTAATAATAGGAAAACGAAAAATTCGAGTA
AAAATGAAAGTAGCAAAGCTTTGTTTGACTCGGTTTTGAGTTGTATGAAT
AATACATATGAAAGTGAATTGACACATAAAGATGATTCTGGGGACTTGTT
AAATTGTTCTCATAATAGTTGGAAATCCGGTGATGATTTGTTTAGTGACT
GTGAGTATGATGTTGAGAGTAATAAATCTAGTAGTTTGTTCAGTTCAATT
CGATCCTGTGTTACGTCTTACAGTAGCAATCGTAGTTTGTCGATAAATGG
AGAAAAGGAAGACGTTTGTTGTAATGAAGTTCTTATGAAACCTTGCCTTT
CAACTGTCAATGAGGTATCTATGGTCAATAGCCTTTATGATCAAACAATA
GTCGAAGTCTGTAAAACCAGAAATACTTGGAATAATTTTCTCAGTGAATT
AGAATCTTGGAAAAAAGTTTTAATTGGTGATTTTTCAAAAAAGAAAATTA
TTTCAATTACTTTGGCTTGGAAATTTGATTGCAATAATGAAATCGAACTT
CTCGGTATTTCTATATTCCCTGAATCTAGTTCCTCAGTATATTATCTTAA
CCTGTTGAATCCAATTGGAAGTCGAGTCAATGTGTCTTTGAAACGTCGAT
CGGAATTTCTCGTTGATCTCTTGTCATTACCTCATTTTCTTTTCGTTTCT
TTCGATTGGATTTTCGTTCTTTCTTTGTTGGAGAGAAAGTTGAATCAGCA
TTTTATGAAACATGACAATTTGATTGATGTGCTGTTGATGGATTGGATGC
TAAATTCTGAGAACTGCTGTCATACTTTCTTAGACATATGCAATAAGTAT
AATATCAGGCTTAATAATAAACTGAAAGTGCCGATAAATAATAAGCTTGT
CGATATTGTTAAGATAGGTGACCGTGATTTAACACCTTCAAACGTCATTG
CGACAGACAAGGACGCAGCAAACCAAGCACTAGTATTACTTGAAATATGT
ATTTGCATTAGAAAGCAGTTTATTATGACATGGTCAAATAGTTCGTCCTT
ATATAAGCACTTCTCTTTTATTGAGATGAATATAAGCTATATTATTGACC
AAGCTCCTGGTTTCGGTGTTAACTTTTCCGTGATGGAATCACAAATTAAA
GAGGTCAAACGTACTGTTGATATATTAAAACAAATGGCATTTATTGTTTC
TGGCAAGACGTTTAATATTGATAGCCCGAAAGAAGTTTCAAAATTGCTAT
TCATAGAAATGAGATTTCCAGTTCAGGGAATTTTTAACGGAGGAAAGATT
ACGCGCAAAAATTCCACGTCTAAAATAACAGCGTCAACCAAGAAAAATTT
GAATCACTTATTGTCTCTTCATCCGTTACCTGGGCTAATTCTCGAATATC
GACATCTTGGAATGCTAGTTGAAAAAACTCTCAATCCTCTTTTCGAGGCT
TGCAAAAAAGTTGTGATAGCTAACTCCACCACAAATCCAAAAATTAAATG
CATATACCAGCAATTATCAAGCACTGGCCGACTGAACTCAACCAGTCCGA
ATTTGCAGTCTGTGCCGAAACCCATACAGATAAACTGGTTCAAATTGTTA
CATTTAGACAAAAGAGATTTGTTCAAAAATAAAGCAAAAGAGCTAGGAAT
TGATAAAAATGAAGATTCAGTTATTTGTAATTTTCGATCTTGTTTTAATG
CTTCACACGGCTTTGTGTTGGTTACTGCCGACTATCGTCAGTTAGAGTTG
AGAATTCTTTCGCACTTTTCACGAGATCCTGCATTGATTGGTTTTTTCAT
CAACCAACCAGATGTCGATATATTTATCAAGATGGCGAGCAAGTGGTTGA
AGAAACCAATGGAATCTATAACGGATGTTGATAGACAACAGGCAAAACAA
ATCAGTTATGGAATAATTTATGGAATTTCTGCTCAAGGCCTGTCGGAACA
AATGTCAATAGAAGAATCGAAAGCTGAACAGATGATAAATGAATTTATGA
TAGCATTTCCAGGTGTAAGTCAGTTCATAAAATCCACTATTGACATTTGT
CGTAAAAACGGATTCATTGAAACGATAACCGGACGTCGTAGATATTTGCC
TGACATTATTTCTGAAAATCCGTTTTGTCGATCACATGCTGAAAGACAAG
CAATCCATTCAACAATTCAAGGAAGTGCAGCAGATATTGTCAAAACTGCA
ATGGTAATGGTTGATAATGCCATAACTGCAGATTACAAGAATAAATCCTT
TCATCGCAAATCACTCAATCAGATTCCTGCCATGGTTCTTCATTTACACG
ATGAAATTTTATATGAGGTGCCTCTCAACTATATGCATAACATGGCGGTC
ATATTGAAACAGTGCATGGAGAAATCCTATGACCTCAAAGTGTCATTGCC
AGTAAAAGTTAAAACTGGAACAGTTTGGTCAGAATTAAATGATTTCATTG
TTTAGTTATATATACATTTATGATTTTTCGTTTTCAATGATATGGATATT
TTTCGGTGTTTTTATAGTGATTATTGTGATTGATTCTAC

protein sequence of SMED30017838-orf-1

>SMED30017838-orf-1 ID=SMED30017838-orf-1|Name=SMED30017838-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1792bp
MNFLIGDEIIIDKDNVFLPQNVFNQYNELGITSLFSWQSECIKLNGVLDG
SKNLVYSAPTSAGKTLVSEIILLKRVLELKKKVLFILPYVSVSKEKMVYF
QKLFGGIGLKIGGFMGDMSPKGGLATVDIAVCTIEKANNLVNRLIDDGSL
EELSLLVIDELHMLGDEHRGYILELLLTKILYHSKTMKENDPNYRETQII
GMSATLPNLNVVAQWLKAELYVCDYRPIPLQEMMKCDSKIYDCKDLSTPI
RMFNCPSGVIKTDEDQILGLCLETILEGHGCLVFCPTKKWCETMSKNLAK
ELTPVYLSMNTAIDWTCFYNVVNSFSEAELRVMILVGIEEKFLIKYSVSG
RTSTRHSDDPKYRRFYSSLILYHLVNEFSFQQVTEKFNVEKGSLQSLQMQ
AATYAGMVTIFCNRLGWSHLEVLMTSFQRRMIFGVSGDLVDLVRLSLMNA
CRARIFFKAGLETISSIAGAKVKEITNLLRKSLPFQSAKVGDHIEEMKYN
SNNSDRILGPNGKSLKLEEAAMEMISESQMLLKRDLQLMGIEWNPPTLVK
IDENISEVSDSNIPQIDINNSLNKSTSNDKEISSRSTINCEDKENFNPSD
LSPYNDTTKTKCKIAENVDINLSRDKTKQFHEYTLRSRCEPRIMSSVDTI
DKKSDKSKRLSGGSSSSITKEISFLNLDSSGSNSYETCETSICPLHETQD
TKNQACHIKIDKKNPKKSKILSKHLIDSKTKTNKNVSGNNTQRNVKHSIK
SQSLMQIQNSNCDLNNTLKDHSHESSNIKKEVMDKMRSSIESKNVIPPFR
TEYGNTREINNSVEPSIIMKSDGKGDSNKMDDCFNVEDLSFSDDSIKTPV
TADPFDSPLRTNSNENGASHSHIMKDGDSFELLMNDDLNTLNNQSVKSND
LSFPSIIDNKNTTEISPNSLKRSPIEMSTPIGKKNNKKLRFENLFDQKMS
PLTTNEEDSEILVPNSQPMFKTPILNTNRKTNNRKTKNSSKNESSKALFD
SVLSCMNNTYESELTHKDDSGDLLNCSHNSWKSGDDLFSDCEYDVESNKS
SSLFSSIRSCVTSYSSNRSLSINGEKEDVCCNEVLMKPCLSTVNEVSMVN
SLYDQTIVEVCKTRNTWNNFLSELESWKKVLIGDFSKKKIISITLAWKFD
CNNEIELLGISIFPESSSSVYYLNLLNPIGSRVNVSLKRRSEFLVDLLSL
PHFLFVSFDWIFVLSLLERKLNQHFMKHDNLIDVLLMDWMLNSENCCHTF
LDICNKYNIRLNNKLKVPINNKLVDIVKIGDRDLTPSNVIATDKDAANQA
LVLLEICICIRKQFIMTWSNSSSLYKHFSFIEMNISYIIDQAPGFGVNFS
VMESQIKEVKRTVDILKQMAFIVSGKTFNIDSPKEVSKLLFIEMRFPVQG
IFNGGKITRKNSTSKITASTKKNLNHLLSLHPLPGLILEYRHLGMLVEKT
LNPLFEACKKVVIANSTTNPKIKCIYQQLSSTGRLNSTSPNLQSVPKPIQ
INWFKLLHLDKRDLFKNKAKELGIDKNEDSVICNFRSCFNASHGFVLVTA
DYRQLELRILSHFSRDPALIGFFINQPDVDIFIKMASKWLKKPMESITDV
DRQQAKQISYGIIYGISAQGLSEQMSIEESKAEQMINEFMIAFPGVSQFI
KSTIDICRKNGFIETITGRRRYLPDIISENPFCRSHAERQAIHSTIQGSA
ADIVKTAMVMVDNAITADYKNKSFHRKSLNQIPAMVLHLHDEILYEVPLN
YMHNMAVILKQCMEKSYDLKVSLPVKVKTGTVWSELNDFIV*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0003682	chromatin binding
GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity
GO:0051575	5'-deoxyribose-5-phosphate lyase activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0003677	DNA binding
GO:0003676	nucleic acid binding
GO:0005524	ATP binding

Vocabulary: **biological process**
Term	Definition
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006302	double-strand break repair
GO:0006974	cellular response to DNA damage stimulus
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0032508	DNA duplex unwinding
GO:0051260	protein homooligomerization
GO:0097681	double-strand break repair via alternative nonhomologous end joining
GO:2000042	negative regulation of double-strand break repair via homologous recombination
GO:0006261	DNA-dependent DNA replication
GO:0006260	DNA replication
GO:0071897	DNA biosynthetic process

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR002298	DNA_polymerase_A
IPR014001	Helicase_ATP-bd
IPR001098	DNA-dir_DNA_pol_A_palm_dom
IPR011545	DEAD/DEAH_box_helicase_dom
IPR027417	P-loop_NTPase
IPR019760	DNA-dir_DNA_pol_A_CS

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 1618..1638
None	No IPR available	GENE3D	G3DSA:1.20.1060.10		coord: 1343..1463 e-value: 2.2E-15 score: 58.6
None	No IPR available	GENE3D	G3DSA:3.40.50.300		coord: 19..227 e-value: 1.9E-55 score: 188.9
None	No IPR available	GENE3D	G3DSA:1.10.3380.20		coord: 295..458 e-value: 6.8E-18 score: 66.8
None	No IPR available	GENE3D	G3DSA:1.10.150.20		coord: 1555..1700 e-value: 4.2E-81 score: 274.0
None	No IPR available	GENE3D	G3DSA:3.30.70.370		coord: 1481..1783 e-value: 4.2E-81 score: 274.0
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 976..995
None	No IPR available	PANTHER	PTHR10133:SF42	DNA POLYMERASE THETA	coord: 1349..1789 coord: 302..764 coord: 18..302
None	No IPR available	CDD	cd18795	SF2_C_Ski2	coord: 226..299 e-value: 2.16485E-10 score: 58.7186
None	No IPR available	CDD	cd18026	DEXHc_POLQ-like	coord: 18..227 e-value: 8.52039E-93 score: 296.82
None	No IPR available	CDD	cd08638	DNA_pol_A_theta	coord: 1418..1786 e-value: 2.66364E-127 score: 401.604
None	No IPR available	SUPERFAMILY	SSF56672	DNA/RNA polymerases	coord: 1342..1786
None	No IPR available	SUPERFAMILY	SSF158702	Sec63 N-terminal domain-like	coord: 358..481
IPR002298	DNA polymerase A	PRINTS	PR00868	DNAPOLI	coord: 1693..1709 score: 58.82 coord: 1471..1493 score: 45.15
IPR002298	DNA polymerase A	PANTHER	PTHR10133	DNA POLYMERASE I	coord: 302..764 coord: 18..302
IPR002298	DNA polymerase A	PANTHER	PTHR10133	DNA POLYMERASE I	coord: 1349..1789
IPR014001	Helicase superfamily 1/2, ATP-binding domain	SMART	SM00487	ultradead3	coord: 30..233 e-value: 1.3E-20 score: 84.5
IPR014001	Helicase superfamily 1/2, ATP-binding domain	PROSITE	PS51192	HELICASE_ATP_BIND_1	coord: 45..224 score: 19.148
IPR001098	DNA-directed DNA polymerase, family A, palm domain	SMART	SM00482	polaultra3	coord: 1536..1751 e-value: 1.3E-73 score: 260.6
IPR001098	DNA-directed DNA polymerase, family A, palm domain	PFAM	PF00476	DNA_pol_A	coord: 1352..1785 e-value: 2.7E-100 score: 336.1
IPR011545	DEAD/DEAH box helicase domain	PFAM	PF00270	DEAD	coord: 38..207 e-value: 2.3E-17 score: 63.3
IPR019760	DNA-directed DNA polymerase, family A, conserved site	PROSITE	PS00447	DNA_POLYMERASE_A	coord: 1602..1621
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	coord: 11..221
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	coord: 150..334