HD domain-containing protein

Overview
NameHD domain-containing protein
Smed IDSMED30017732
Length (bp)701
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of HD domain-containing protein (SMED30017732) t-SNE clustered cells

Violin plots show distribution of expression levels for HD domain-containing protein (SMED30017732) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of HD domain-containing protein (SMED30017732) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for HD domain-containing protein (SMED30017732) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30017732

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30017732SMESG000000192.1 SmedASXL_009209SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30017732SMESG000000192.1 SmedASXL_009209SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of HD domain-containing protein vs. Ensembl Human
Match: HDDC2 (HD domain containing 2 [Source:HGNC Symbol;Acc:HGNC:21078])

HSP 1 Score: 139.428 bits (350), Expect = 1.542e-40
Identity = 81/164 (49.39%), Postives = 107/164 (65.24%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKF 540
            + FL  VGQLK   RTGWV   V  PESVSDHMYRMA M+ ++       + +++ +R +++AL+HD+AECIVGDI P     K +K + E EAM  I + + ++L  E+ ELW EY  Q + EAK  K  D+ +MILQA EYE  E+KP  LQDF+DST GKF
Sbjct:   18 LQFLRLVGQLKRVPRTGWVYRNVQRPESVSDHMYRMAVMAMVI------KDDRLNKDRCVRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKQITQLLPEDLRKELYELWEEYETQSSAEAKFVKQLDQCEMILQASEYEDLEHKPGRLQDFYDSTAGKF 175
[Close]
BLAST of HD domain-containing protein vs. Ensembl Human
Match: HDDC2 (HD domain containing 2 [Source:HGNC Symbol;Acc:HGNC:21078])

HSP 1 Score: 90.8929 bits (224), Expect = 6.596e-23
Identity = 43/91 (47.25%), Postives = 59/91 (64.84%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLE 321
            + FL  VGQLK   RTGWV   V  PESVSDHMYRMA M+ ++       + +++ +R +++AL+HD+AECIVGDI P     K +K + E
Sbjct:   18 LQFLRLVGQLKRVPRTGWVYRNVQRPESVSDHMYRMAVMAMVI------KDDRLNKDRCVRLALVHDMAECIVGDIAPADNIPKEEKHRRE 102
[Close]
BLAST of HD domain-containing protein vs. Ensembl Human
Match: HDDC2 (HD domain containing 2 [Source:HGNC Symbol;Acc:HGNC:21078])

HSP 1 Score: 89.7373 bits (221), Expect = 1.415e-22
Identity = 43/89 (48.31%), Postives = 58/89 (65.17%), Query Frame = 1 
Query:   55 FLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLE 321
            FL  VGQLK   RTGWV   V  PESVSDHMYRMA M+ ++       + +++ +R +++AL+HD+AECIVGDI P     K +K + E
Sbjct:   20 FLRLVGQLKRVPRTGWVYRNVQRPESVSDHMYRMAVMAMVI------KDDRLNKDRCVRLALVHDMAECIVGDIAPADNIPKEEKHRRE 102
[Close]
BLAST of HD domain-containing protein vs. Ensembl Human
Match: HDDC2 (HD domain containing 2 [Source:HGNC Symbol;Acc:HGNC:21078])

HSP 1 Score: 58.5362 bits (140), Expect = 3.759e-11
Identity = 28/54 (51.85%), Postives = 34/54 (62.96%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKV 210
            + FL  VGQLK   RTGWV   V  PESVSDHMYRMA M+ ++     N + K+
Sbjct:   18 LQFLRLVGQLKRVPRTGWVYRNVQRPESVSDHMYRMAVMAMVIKDDRLNKDRKL 71
[Close]
BLAST of HD domain-containing protein vs. Ensembl Human
Match: HDDC2 (HD domain containing 2 [Source:HGNC Symbol;Acc:HGNC:21078])

HSP 1 Score: 58.5362 bits (140), Expect = 3.759e-11
Identity = 28/54 (51.85%), Postives = 34/54 (62.96%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKV 210
            + FL  VGQLK   RTGWV   V  PESVSDHMYRMA M+ ++     N + K+
Sbjct:   18 LQFLRLVGQLKRVPRTGWVYRNVQRPESVSDHMYRMAVMAMVIKDDRLNKDRKL 71
[Close]
BLAST of HD domain-containing protein vs. Ensembl Celegans
Match: F45F2.9 (pep chromosome:WBcel235:V:8512689:8513461:-1 gene:WBGene00018481.1 transcript:F45F2.9b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F45F2.9)

HSP 1 Score: 125.561 bits (314), Expect = 6.836e-36
Identity = 74/187 (39.57%), Postives = 102/187 (54.55%), Query Frame = 1 
Query:   52 DFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDEIE 612
            + L  +  LK+  RTGWV  GV +PE+V+ HMYRMA ++  L          +D  R +KMAL+HD+ E I GDITP+CG +   K  LE +A+ TI   V   +  E   LW EY    +  A++ K  D+FDMI+QA +YEK       LQ FF ST G    +    W ++L E R   I++ E
Sbjct:    8 ELLDVLDNLKHLKRTGWVKCGVPEPETVACHMYRMAVLAMALEGQIDG----LDAIRTVKMALVHDIGEAIAGDITPHCGVSDQDKFDLEKKAINTIASFV-PNVGEEWTMLWKEYEEASSLTARVVKHLDKFDMIVQADKYEKTHEID--LQQFFTSTVGVLKMEPFATWDRELRENRMKRINKAE 187
[Close]
BLAST of HD domain-containing protein vs. Ensembl Celegans
Match: F45F2.9 (pep chromosome:WBcel235:V:8512689:8513463:-1 gene:WBGene00018481.1 transcript:F45F2.9a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F45F2.9)

HSP 1 Score: 49.2914 bits (116), Expect = 4.754e-8
Identity = 29/76 (38.16%), Postives = 40/76 (52.63%), Query Frame = 1 
Query:  385 LWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDEIE 612
            LW EY    +  A++ K  D+FDMI+QA +YEK       LQ FF ST G    +    W ++L E R   I++ E
Sbjct:    2 LWKEYEEASSLTARVVKHLDKFDMIVQADKYEKTHEID--LQQFFTSTVGVLKMEPFATWDRELRENRMKRINKAE 75
[Close]
BLAST of HD domain-containing protein vs. Ensembl Fly
Match: CG11050 (gene:FBgn0031836 transcript:FBtr0079291)

HSP 1 Score: 169.859 bits (429), Expect = 1.220e-50
Identity = 88/183 (48.09%), Postives = 119/183 (65.03%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCL 597
            + F+  +G LK+T RTGWV   VND ES+S HMYRM+ ++FLL      N+I     R M++AL+HDLAE +VGDITP CG +K  K  +E +AM  I K + +     IMEL+ EY +  T E+K  KD DR DM++QA+EYEK++N     Q+FFDSTEGKF+   VK    ++YE+R  L
Sbjct:  181 LQFMELIGNLKHTKRTGWVLRDVNDCESISGHMYRMSMLTFLLDGSEGLNQI-----RCMELALVHDLAESLVGDITPFCGISKDDKRAMEFKAMEDICKLI-EPRGKRIMELFEEYEHGQTAESKFVKDLDRLDMVMQAFEYEKRDNCLLKHQEFFDSTEGKFNHPFVKKLVNEIYEQRDVL 357
[Close]
BLAST of HD domain-containing protein vs. Ensembl Fly
Match: CG11050 (gene:FBgn0031836 transcript:FBtr0079293)

HSP 1 Score: 169.859 bits (429), Expect = 1.220e-50
Identity = 88/183 (48.09%), Postives = 119/183 (65.03%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCL 597
            + F+  +G LK+T RTGWV   VND ES+S HMYRM+ ++FLL      N+I     R M++AL+HDLAE +VGDITP CG +K  K  +E +AM  I K + +     IMEL+ EY +  T E+K  KD DR DM++QA+EYEK++N     Q+FFDSTEGKF+   VK    ++YE+R  L
Sbjct:  181 LQFMELIGNLKHTKRTGWVLRDVNDCESISGHMYRMSMLTFLLDGSEGLNQI-----RCMELALVHDLAESLVGDITPFCGISKDDKRAMEFKAMEDICKLI-EPRGKRIMELFEEYEHGQTAESKFVKDLDRLDMVMQAFEYEKRDNCLLKHQEFFDSTEGKFNHPFVKKLVNEIYEQRDVL 357
[Close]
BLAST of HD domain-containing protein vs. Ensembl Fly
Match: CG11050 (gene:FBgn0031836 transcript:FBtr0079292)

HSP 1 Score: 169.859 bits (429), Expect = 1.220e-50
Identity = 88/183 (48.09%), Postives = 119/183 (65.03%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCL 597
            + F+  +G LK+T RTGWV   VND ES+S HMYRM+ ++FLL      N+I     R M++AL+HDLAE +VGDITP CG +K  K  +E +AM  I K + +     IMEL+ EY +  T E+K  KD DR DM++QA+EYEK++N     Q+FFDSTEGKF+   VK    ++YE+R  L
Sbjct:  181 LQFMELIGNLKHTKRTGWVLRDVNDCESISGHMYRMSMLTFLLDGSEGLNQI-----RCMELALVHDLAESLVGDITPFCGISKDDKRAMEFKAMEDICKLI-EPRGKRIMELFEEYEHGQTAESKFVKDLDRLDMVMQAFEYEKRDNCLLKHQEFFDSTEGKFNHPFVKKLVNEIYEQRDVL 357
[Close]
BLAST of HD domain-containing protein vs. Ensembl Zebrafish
Match: hddc2 (HD domain containing 2 [Source:NCBI gene;Acc:554129])

HSP 1 Score: 176.407 bits (446), Expect = 2.835e-55
Identity = 89/184 (48.37%), Postives = 116/184 (63.04%), Query Frame = 1 
Query:   37 MNNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKR 588
            M+N + F+  VGQLK   RTGWV   +  PESVSDHMYRM+ M+  +       +I V+  R MK+AL+HDLAECIVGDI P    +KA+K + E +AM+ I   +   L  EI  LW EY  Q + EAK+ K+ D  +MI+QA+EYE+ E KP  LQ+FF STEGKF    V G  + L E+R
Sbjct:    1 MDNMLQFMKLVGQLKRVPRTGWVYRNIKQPESVSDHMYRMSMMALTI------QDISVNKERCMKLALVHDLAECIVGDIAPADNVSKAEKHRREKDAMVHITGLLDDGLRKEIYNLWEEYETQSSPEAKLVKELDNLEMIIQAHEYEELEGKPGRLQEFFVSTEGKFHHPEVLGLLKSLNEER 178
[Close]
BLAST of HD domain-containing protein vs. Ensembl Zebrafish
Match: hddc2 (HD domain containing 2 [Source:NCBI gene;Acc:554129])

HSP 1 Score: 122.865 bits (307), Expect = 5.434e-35
Identity = 62/123 (50.41%), Postives = 80/123 (65.04%), Query Frame = 1 
Query:  220 RIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKR 588
            R MK+AL+HDLAECIVGDI P    +KA+K + E +AM+ I   +   L  EI  LW EY  Q + EAK+ K+ D  +MI+QA+EYE+ E KP  LQ+FF STEGKF    V G  + L E+R
Sbjct:   13 RCMKLALVHDLAECIVGDIAPADNVSKAEKHRREKDAMVHITGLLDDGLRKEIYNLWEEYETQSSPEAKLVKELDNLEMIIQAHEYEELEGKPGRLQEFFVSTEGKFHHPEVLGLLKSLNEER 135
[Close]
BLAST of HD domain-containing protein vs. Ensembl Xenopus
Match: HDDC2 (HD domain containing 2 [Source:NCBI gene;Acc:100379693])

HSP 1 Score: 164.466 bits (415), Expect = 1.703e-50
Identity = 83/184 (45.11%), Postives = 115/184 (62.50%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLI 600
            + F+  VGQLK   RTGW+   V  PESVSDHMYRMA M+ L        + K++ +R +++AL+HD+AECIVGDI P    +K +K + E +AM  + + +   L  E+  LW EY +Q T EAK  K+ D+ +MILQA EYE+ EN+P  LQDF++ST GKF+   V      +YE+R   I
Sbjct:   15 LQFMKLVGQLKRVPRTGWIYRQVEKPESVSDHMYRMAVMAML------TEDRKLNKDRCIRLALVHDMAECIVGDIAPADNISKEEKHRKEKDAMQHLTQLLPDILKTEVYNLWEEYEHQSTAEAKFVKELDQCEMILQALEYEELENRPGRLQDFYNSTAGKFNHPEVVQLVSAIYEERDSAI 192
[Close]
BLAST of HD domain-containing protein vs. Ensembl Mouse
Match: Hddc2 (HD domain containing 2 [Source:MGI Symbol;Acc:MGI:1916942])

HSP 1 Score: 144.05 bits (362), Expect = 1.408e-42
Identity = 84/163 (51.53%), Postives = 107/163 (65.64%), Query Frame = 1 
Query:   55 FLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFS 543
            FL  VGQLK   RTGWV   V  PESVSDHMYRMA M+ +        + +++ +R +++AL+HD+AECIVGDI P     K +K + E EAM  I + + ++L  E+ ELW EY  Q +EEAK  K  D+ +MILQA EYE  ENKP  LQDF+DST GKFS
Sbjct:   15 FLRLVGQLKRVPRTGWVYRNVEKPESVSDHMYRMAVMAMV------TRDDRLNKDRCIRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKQITQLLPEDLRKELYELWEEYETQSSEEAKFVKQLDQCEMILQASEYEDLENKPGRLQDFYDSTAGKFS 171
[Close]
BLAST of HD domain-containing protein vs. Ensembl Mouse
Match: Hddc2 (HD domain containing 2 [Source:MGI Symbol;Acc:MGI:1916942])

HSP 1 Score: 91.2781 bits (225), Expect = 4.358e-23
Identity = 49/107 (45.79%), Postives = 68/107 (63.55%), Query Frame = 1 
Query:   70 GQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELW 390
            GQLK   RTGWV   V  PESVSDHMYRMA M+ +        + +++ +R +++AL+HD+AECIVGDI P     K +K + E EAM  I + + ++L  E+ ELW
Sbjct:    1 GQLKRVPRTGWVYRNVEKPESVSDHMYRMAVMAMV------TRDDRLNKDRCIRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKQITQLLPEDLRKELYELW 101
[Close]
BLAST of HD domain-containing protein vs. UniProt/SwissProt
Match: sp|Q54FK1|HDDC2_DICDI (5'-deoxynucleotidase HDDC2 OS=Dictyostelium discoideum OX=44689 GN=hddc2 PE=3 SV=1)

HSP 1 Score: 178.333 bits (451), Expect = 3.006e-55
Identity = 98/191 (51.31%), Postives = 122/191 (63.87%), Query Frame = 1 
Query:   37 MNNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLL--PAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKK----ENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRK 591
            M+N ++F    G+LK   RTGWVN+GV  PESVSDHMYRMA M   L    +   +  ++D  +I+KMAL+HDL E +VGD TP+   TK +K QLE  A+I I  T+  E+  EI +LW EY +  T EA + KDFD+F+MILQAYEYEK+    ENK K LQ FFDST GKF   L K  A  L   RK
Sbjct:    1 MSNYLEFFKICGKLKTLKRTGWVNHGVELPESVSDHMYRMAMMGMCLDKKELIGEDGKEIDKMKIIKMALVHDLGESLVGDFTPHDKITKEEKYQLEKNAIIEITNTLSGEVGKEIFDLWQEYEDCKTNEALLVKDFDKFEMILQAYEYEKQPHQLENKIK-LQSFFDSTRGKFHHPLFKSLALQLESDRK 190
[Close]
BLAST of HD domain-containing protein vs. UniProt/SwissProt
Match: sp|Q1LUI2|HDDC2_DANRE (5'-deoxynucleotidase HDDC2 OS=Danio rerio OX=7955 GN=hddc2 PE=2 SV=1)

HSP 1 Score: 176.407 bits (446), Expect = 2.140e-54
Identity = 89/184 (48.37%), Postives = 116/184 (63.04%), Query Frame = 1 
Query:   37 MNNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKR 588
            M+N + F+  VGQLK   RTGWV   +  PESVSDHMYRM+ M+  +       +I V+  R MK+AL+HDLAECIVGDI P    +KA+K + E +AM+ I   +   L  EI  LW EY  Q + EAK+ K+ D  +MI+QA+EYE+ E KP  LQ+FF STEGKF    V G  + L E+R
Sbjct:    1 MDNMLQFMKLVGQLKRVPRTGWVYRNIKQPESVSDHMYRMSMMALTI------QDISVNKERCMKLALVHDLAECIVGDIAPADNVSKAEKHRREKDAMVHITGLLDDGLRKEIYNLWEEYETQSSPEAKLVKELDNLEMIIQAHEYEELEGKPGRLQEFFVSTEGKFHHPEVLGLLKSLNEER 178
[Close]
BLAST of HD domain-containing protein vs. UniProt/SwissProt
Match: sp|Q66L17|HDDC2_XENLA (5'-deoxynucleotidase HDDC2 OS=Xenopus laevis OX=8355 GN=hddc2 PE=2 SV=1)

HSP 1 Score: 163.31 bits (412), Expect = 2.474e-49
Identity = 82/186 (44.09%), Postives = 113/186 (60.75%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDE 606
            + F+  VGQLK   RTGW+   V  PESVSDHMYRMA M+ L        + K++ +R +++AL+HD+AECIVGDI P     K +K + E  AM  + + +   L  E+ +LW EY +Q T EAK  K+ D+ +MILQA EYE+ E +P  LQDF++ST GKF    +      +YE+R   I E
Sbjct:   15 LQFMKLVGQLKRVPRTGWIYRQVEKPESVSDHMYRMAVMAML------TEDRKLNKDRCIRLALVHDMAECIVGDIAPADNIAKEEKHRKEKAAMEHLTQLLPDNLKTEVYDLWEEYEHQFTAEAKFVKELDQCEMILQALEYEELEKRPGRLQDFYNSTAGKFKHPEIVQLVSAIYEERNSAIAE 194
[Close]
BLAST of HD domain-containing protein vs. UniProt/SwissProt
Match: sp|Q3SXD3|HDDC2_MOUSE (5'-deoxynucleotidase HDDC2 OS=Mus musculus OX=10090 GN=Hddc2 PE=1 SV=1)

HSP 1 Score: 144.05 bits (362), Expect = 9.851e-42
Identity = 84/163 (51.53%), Postives = 107/163 (65.64%), Query Frame = 1 
Query:   55 FLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFS 543
            FL  VGQLK   RTGWV   V  PESVSDHMYRMA M+ +        + +++ +R +++AL+HD+AECIVGDI P     K +K + E EAM  I + + ++L  E+ ELW EY  Q +EEAK  K  D+ +MILQA EYE  ENKP  LQDF+DST GKFS
Sbjct:   15 FLRLVGQLKRVPRTGWVYRNVEKPESVSDHMYRMAVMAMV------TRDDRLNKDRCIRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKQITQLLPEDLRKELYELWEEYETQSSEEAKFVKQLDQCEMILQASEYEDLENKPGRLQDFYDSTAGKFS 171
[Close]
BLAST of HD domain-containing protein vs. UniProt/SwissProt
Match: sp|P87242|HDD1_SCHPO (5'-deoxynucleotidase hdd1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=hdd1 PE=3 SV=1)

HSP 1 Score: 142.124 bits (357), Expect = 4.389e-41
Identity = 79/186 (42.47%), Postives = 117/186 (62.90%), Query Frame = 1 
Query:   49 VDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKT-VGKELS---NEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKF-SSDLVKGWAQDLYEKRK 591
            V FL  + +LK T RTGW+ +G+  PES++DHMYRM  ++ L       N+  ++  R +K+A++HD+AE IVGDITP+   +K +K ++E+EAM++I +  +   LS    EI EL+ EY +  T EAK  KD D+F+MI Q +EYE+K N  K L  F  +  GK     LVKGW  D+ ++R+
Sbjct:   10 VPFLDCLSRLKTTPRTGWLYHGIEKPESIADHMYRMGILTMLC------NDPSINKERCLKIAVVHDMAESIVGDITPHENVSKEEKHRMESEAMVSITQQLIPLNLSLQAEEIKELFLEYESASTPEAKFVKDIDKFEMIAQMFEYERKFNGEKDLSQF--TWAGKLIQHPLVKGWLNDVLQERE 187
[Close]
BLAST of HD domain-containing protein vs. TrEMBL
Match: A0A5K4EZX9 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 206.453 bits (524), Expect = 8.371e-64
Identity = 98/191 (51.31%), Postives = 134/191 (70.16%), Query Frame = 1 
Query:   40 NNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDEIE 612
            +N + FLL  G+LK TVRTGW  Y +N PESVSDHMYRMA M+ ++PA    N   ++ NR++KMA++HDLAECIVGDITP+CG +K +KL  E +AM  + + + +E   EIM+LW EY +Q T EA I KDFD+F+M+LQAYEYE +  +P  L+ FF+ST G FS+ L + W ++L   R+ L  + E
Sbjct:    4 SNVLRFLLLCGKLKRTVRTGWTRYNINSPESVSDHMYRMALMATVIPADEREN---LNTNRLIKMAIVHDLAECIVGDITPHCGVSKEEKLSREKDAMKQLCELISEENRTEIMDLWKEYVDQKTPEAVICKDFDKFEMLLQAYEYEHETLEPGKLESFFESTLGTFSTSLGQKWVRELCSLRRNLFIQCE 191
[Close]
BLAST of HD domain-containing protein vs. TrEMBL
Match: A0A4E0RV22 (HD domain containing protein 2 OS=Fasciola hepatica OX=6192 GN=D915_003004 PE=4 SV=1)

HSP 1 Score: 204.912 bits (520), Expect = 3.726e-63
Identity = 99/200 (49.50%), Postives = 136/200 (68.00%), Query Frame = 1 
Query:   40 NNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDEIEMTKEDHWRP 639
            +N + FL   G+LK TVRTGW  Y ++ PESVSDHMYRMA MS ++P +     I VD  R++KM ++HDLAECIVGDITP+C  ++ +KL+ ETEAM  + + + KE + EI+ LW EYN Q T EA + KDFD+F+M++QA+EYEK+  KP  L +FF+ST G FS+ LVK W   L ++R+      +  + DH  P
Sbjct:    4 SNILQFLFMCGRLKRTVRTGWTRYEIDQPESVSDHMYRMALMSTIIP-VQERESISVD--RLLKMTVVHDLAECIVGDITPHCNVSREEKLRRETEAMDRLCQLIPKENAEEILLLWQEYNTQSTPEAVLCKDFDKFEMLVQAFEYEKEMCKPNKLSEFFESTLGCFSTPLVKDWVTSLCDERQ------KFAQGDHQSP 194
[Close]
BLAST of HD domain-containing protein vs. TrEMBL
Match: A0A0R3T2A8 (HD domain-containing protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS1058 PE=4 SV=1)

HSP 1 Score: 201.445 bits (511), Expect = 7.419e-62
Identity = 94/182 (51.65%), Postives = 127/182 (69.78%), Query Frame = 1 
Query:   43 NSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKR 588
            N V FLL  G++K TVRTGW  YGVN+PESVSDHMYRMA +S LLP+            ++MKMA+IHDLAECIVGDITP CG +K +K + E EA+  I  ++ +++  E++ LW EY+ Q T E+ + KD D+F+MILQAYEYE + N+P +L++FF STEG F+   V+ W   L ++R
Sbjct:    5 NVVRFLLACGKIKRTVRTGWTRYGVNEPESVSDHMYRMALLSILLPSTE-----AFKPEKVMKMAIIHDLAECIVGDITPFCGVSKQEKHRREEEAITFICSSLPEDIGPELVSLWKEYDEQKTPESLVCKDLDKFEMILQAYEYELEANRPGWLEEFFKSTEGLFTYPCVREWVDALRKER 181
[Close]
BLAST of HD domain-containing protein vs. TrEMBL
Match: A0A564YU15 (HD domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS9193 PE=4 SV=1)

HSP 1 Score: 195.667 bits (496), Expect = 1.273e-59
Identity = 90/178 (50.56%), Postives = 122/178 (68.54%), Query Frame = 1 
Query:   55 FLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKR 588
            FLL  G++K TVRTGW  YGVN+PESV+DHMYRMA +S LLP+            ++MKMA++HDLAECIVGDITP CG +K +K + E EA+ +I   +  +   EI+ LW EY  Q T E+ + KD D+F+MILQAYEYE + N+P +L++FF S+EG F+   V+ W   L ++R
Sbjct:    9 FLLACGKIKRTVRTGWTRYGVNEPESVADHMYRMALLSTLLPSTED-----FKPEKVMKMAIVHDLAECIVGDITPFCGISKQEKHRREEEAITSICSVLSGDTGAEIINLWKEYEGQKTPESVVCKDLDKFEMILQAYEYEMEANRPGWLEEFFKSSEGVFTYPCVREWVDALRKER 181
[Close]
BLAST of HD domain-containing protein vs. TrEMBL
Match: A0A068WS16 (Metal dependent phosphohydrolase HD region OS=Echinococcus granulosus OX=6210 GN=EgrG_000690400 PE=4 SV=1)

HSP 1 Score: 192.2 bits (487), Expect = 2.768e-58
Identity = 91/184 (49.46%), Postives = 125/184 (67.93%), Query Frame = 1 
Query:   55 FLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDE 606
            FLL  G++K TVR GW  +GVN+PE+V+DHMYRMA +S LLP+     + K D  ++MKMA+IHDLAEC+VGDITP CG +  +K   E  A+I++ K +  EL NE++ LW EY  + T EA + KD D+F+MILQAYEYE +  KP +L++FF +TEG F+   V+ W   L + R   + E
Sbjct:    9 FLLACGKIKRTVRAGWTRHGVNEPENVADHMYRMALLSALLPS---TEDFKPD--KVMKMAIIHDLAECVVGDITPFCGISVEEKHAREEAALISLCKELPSELGNELVSLWKEYEERKTPEAVVCKDLDKFEMILQAYEYELEAQKPGWLEEFFTATEGVFTYPCVREWVAALLQLRNASLGE 187
[Close]
BLAST of HD domain-containing protein vs. Ensembl Cavefish
Match: hddc2 (HD domain containing 2 [Source:NCBI gene;Acc:103023626])

HSP 1 Score: 174.096 bits (440), Expect = 2.057e-54
Identity = 87/184 (47.28%), Postives = 118/184 (64.13%), Query Frame = 1 
Query:   37 MNNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKR 588
            M N + F+  VGQLK   RTGWV   V  PESVSDHMYRMA M+  +       +  V+ +R +K+AL+HDLAE IVGDI P    +KA+K + E EAM  I   + ++L  E+ +LW EY  Q + EA++ K+FD+ +MILQA+EYE+ E KP  LQ+FFDST+G+F    V    + L E+R
Sbjct:    1 MENMLQFMKLVGQLKRVPRTGWVYRNVQHPESVSDHMYRMAMMALTV------QDTSVNRDRCVKIALVHDLAESIVGDIAPADKISKAEKHRREKEAMDHITGLLREDLRKELYQLWEEYETQSSPEARLVKEFDQLEMILQAHEYEELEGKPGRLQEFFDSTQGRFHHPDVLALVKSLNEER 178
[Close]
BLAST of HD domain-containing protein vs. Ensembl Cavefish
Match: hddc2 (HD domain containing 2 [Source:NCBI gene;Acc:103023626])

HSP 1 Score: 157.532 bits (397), Expect = 2.163e-47
Identity = 79/166 (47.59%), Postives = 108/166 (65.06%), Query Frame = 1 
Query:   91 RTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKR 588
            RTGWV   V  PESVSDHMYRMA M+  +       +  V+ +R +K+AL+HDLAE IVGDI P    +KA+K + E EAM  I   + ++L  E+ +LW EY  Q + EA++ K+FD+ +MILQA+EYE+ E KP  LQ+FFDST+G+F    V    + L E+R
Sbjct:   67 RTGWVYRNVQHPESVSDHMYRMAMMALTV------QDTSVNRDRCVKIALVHDLAESIVGDIAPADKISKAEKHRREKEAMDHITGLLREDLRKELYQLWEEYETQSSPEARLVKEFDQLEMILQAHEYEELEGKPGRLQEFFDSTQGRFHHPDVLALVKSLNEER 226
[Close]
BLAST of HD domain-containing protein vs. Ensembl Sea Lamprey
Match: hddc2 (HD domain containing 2 [Source:NCBI gene;Acc:554129])

HSP 1 Score: 156.762 bits (395), Expect = 2.503e-48
Identity = 77/162 (47.53%), Postives = 106/162 (65.43%), Query Frame = 1 
Query:   79 KNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGW 564
            KN  RTGW+   V DPESV+DHMYRMA ++FL+       +  ++ ++ MK+AL+HD+AE IVGDI P    +K +K + E +AM  I   V +E+  E+  LW EY  Q + EAK+ KD DRF+MI QAYEYE+  ++P  LQDF++STEGKF    +  W
Sbjct:   16 KNVKRTGWIYRRVPDPESVADHMYRMAILAFLI------RDECLNKDKCMKLALVHDMAESIVGDIAPADNVSKEEKHRREEDAMKHISTLVDEEIGKELYSLWEEYEYQRSAEAKLVKDLDRFEMIFQAYEYEQTHHRPGELQDFYNSTEGKFQHPEMVEW 171
[Close]
BLAST of HD domain-containing protein vs. Ensembl Yeast
Match: YGL101W_mRNA (Protein of unknown function; non-essential gene; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome duplication [Source:SGD;Acc:S000003069])

HSP 1 Score: 135.576 bits (340), Expect = 4.600e-40
Identity = 73/195 (37.44%), Postives = 111/195 (56.92%), Query Frame = 1 
Query:   40 NNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMI----TIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDEIE 612
            N  + FL  +  LK   RTGWV++G++  ES+SDHMYRM   + L+   N      VD N+ +++AL+HD AE +VGDITPN   TK +K + E E +     +I++   +  S EI++ W  Y  Q   E +  KD D+++M++Q +EYE+K N  K L+ F  +      +D VK W Q L E R+   D ++
Sbjct:   27 NYQLAFLNIIQLLKTQRRTGWVDHGIDPCESISDHMYRMGLTTMLITDKN------VDRNKCIRIALVHDFAESLVGDITPNDPMTKEEKHRREFETVKYLCESIIRPCSESASREILDDWLAYEKQTCLEGRYVKDIDKYEMLVQCFEYEQKYNGKKDLKQFLGAI-NDIKTDEVKKWTQSLLEDRQAFFDSLK 214
[Close]
BLAST of HD domain-containing protein vs. Ensembl Yeast
Match: YBR242W_mRNA (Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication [Source:SGD;Acc:S000000446])

HSP 1 Score: 120.939 bits (302), Expect = 3.734e-34
Identity = 66/188 (35.11%), Postives = 111/188 (59.04%), Query Frame = 1 
Query:   40 NNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMI----TIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRK 591
            N  + FL  V QLK   RTG+++ G+ + ES+SDHMYR++ ++ L+       + +V+ ++ +++AL+HD+AE +VGDITP     K +K + E E +      ++K   +  + EIM+ W  Y N  + EA+  KD D+++M++Q +EYE++    K   DFF +      +D VKGW  DL  +R+
Sbjct:   46 NYILAFLNVVQQLKIQRRTGYLDLGIKECESISDHMYRLSIITMLI------KDSRVNRDKCVRIALVHDIAESLVGDITPVDPIGKEEKHRREWETIKYLCNALIKPYNEIAAKEIMDDWLAYENVTSLEARYVKDIDKYEMLVQCFEYEREYKGTKNFDDFFGAV-ASIKTDEVKGWTSDLVVQRQ 226
[Close]
BLAST of HD domain-containing protein vs. Ensembl Nematostella
Match: EDO47192 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN12])

HSP 1 Score: 191.815 bits (486), Expect = 6.399e-62
Identity = 94/179 (52.51%), Postives = 123/179 (68.72%), Query Frame = 1 
Query:   55 FLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAIN-HNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKR 588
            FL  VGQLK T RTGWV++GV  PESVSDHMYRMA + FLLP+ +       ++ +  +K+AL+HD+AECIVGD+ P+ G +K +K + E  AM  +    G+E   EI ELW EY  Q + EAK  KD DRF+MILQA+EYE +E+K ++LQDFFDST+GKF   +VK W   L + R
Sbjct:    4 FLSLVGQLKRTKRTGWVDHGVKAPESVSDHMYRMAVICFLLPSKSTAATGDTLNKDHCIKIALVHDIAECIVGDLAPSDGVSKEEKHKREKAAMEELAILAGEEAGKEIYELWEEYEFQKSPEAKFVKDVDRFEMILQAHEYETEEHKTEWLQDFFDSTKGKFGHPVVKDWVASLNKAR 182
[Close]
BLAST of HD domain-containing protein vs. Ensembl Medaka
Match: hddc2 (HD domain containing 2 [Source:NCBI gene;Acc:101158656])

HSP 1 Score: 166.777 bits (421), Expect = 2.140e-51
Identity = 86/184 (46.74%), Postives = 113/184 (61.41%), Query Frame = 1 
Query:   37 MNNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKR 588
            M+N + FL  +GQLK   RTGWV   V +PESVSDHMYRMA MS  +       +  VD +R +K+AL+HD+AE IVGDI P+   +K +K + E EAM  +   + + L  EI  LW EY  Q + EA++ K FD  +MILQA+EYE+ E  P  LQ+FFDST G+F    V      L E+R
Sbjct:   11 MSNMLKFLKIIGQLKRVPRTGWVYRKVKEPESVSDHMYRMAVMSLTI------TDPAVDKDRCIKLALVHDMAESIVGDIAPSDNVSKEEKHRREKEAMRHLTSLLPEGLKKEIYSLWEEYEFQSSSEARLVKQFDLLEMILQAHEYEELEGTPGRLQEFFDSTAGRFQHQDVLQLISSLDEER 188
[Close]
BLAST of HD domain-containing protein vs. Planmine SMEST
Match: SMESG000000192.1 (SMESG000000192.1)

HSP 1 Score: 464.922 bits (1195), Expect = 4.781e-169
Identity = 221/221 (100.00%), Postives = 221/221 (100.00%), Query Frame = 1 
Query:   37 MNNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDEIEMTKEDHWRPSYSQNTRTGPSKYRVNIHVE 699
            MNNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDEIEMTKEDHWRPSYSQNTRTGPSKYRVNIHVE
Sbjct:    1 MNNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMYRMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTKAQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRFDMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLIDEIEMTKEDHWRPSYSQNTRTGPSKYRVNIHVE 221
The following BLAST results are available for this feature:
BLAST of HD domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HDDC21.542e-4049.39HD domain containing 2 [Source:HGNC Symbol;Acc:HGN... [more]
HDDC26.596e-2347.25HD domain containing 2 [Source:HGNC Symbol;Acc:HGN... [more]
HDDC21.415e-2248.31HD domain containing 2 [Source:HGNC Symbol;Acc:HGN... [more]
HDDC23.759e-1151.85HD domain containing 2 [Source:HGNC Symbol;Acc:HGN... [more]
HDDC23.759e-1151.85HD domain containing 2 [Source:HGNC Symbol;Acc:HGN... [more]
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BLAST of HD domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
F45F2.96.836e-3639.57pep chromosome:WBcel235:V:8512689:8513461:-1 gene:... [more]
F45F2.94.754e-838.16pep chromosome:WBcel235:V:8512689:8513463:-1 gene:... [more]
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BLAST of HD domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CG110501.220e-5048.09gene:FBgn0031836 transcript:FBtr0079291[more]
CG110501.220e-5048.09gene:FBgn0031836 transcript:FBtr0079293[more]
CG110501.220e-5048.09gene:FBgn0031836 transcript:FBtr0079292[more]
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BLAST of HD domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
hddc22.835e-5548.37HD domain containing 2 [Source:NCBI gene;Acc:55412... [more]
hddc25.434e-3550.41HD domain containing 2 [Source:NCBI gene;Acc:55412... [more]
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BLAST of HD domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
HDDC21.703e-5045.11HD domain containing 2 [Source:NCBI gene;Acc:10037... [more]
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BLAST of HD domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Hddc21.408e-4251.53HD domain containing 2 [Source:MGI Symbol;Acc:MGI:... [more]
Hddc24.358e-2345.79HD domain containing 2 [Source:MGI Symbol;Acc:MGI:... [more]
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BLAST of HD domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q54FK1|HDDC2_DICDI3.006e-5551.315'-deoxynucleotidase HDDC2 OS=Dictyostelium discoi... [more]
sp|Q1LUI2|HDDC2_DANRE2.140e-5448.375'-deoxynucleotidase HDDC2 OS=Danio rerio OX=7955 ... [more]
sp|Q66L17|HDDC2_XENLA2.474e-4944.095'-deoxynucleotidase HDDC2 OS=Xenopus laevis OX=83... [more]
sp|Q3SXD3|HDDC2_MOUSE9.851e-4251.535'-deoxynucleotidase HDDC2 OS=Mus musculus OX=1009... [more]
sp|P87242|HDD1_SCHPO4.389e-4142.475'-deoxynucleotidase hdd1 OS=Schizosaccharomyces p... [more]
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BLAST of HD domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K4EZX98.371e-6451.31Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A4E0RV223.726e-6349.50HD domain containing protein 2 OS=Fasciola hepatic... [more]
A0A0R3T2A87.419e-6251.65HD domain-containing protein OS=Rodentolepis nana ... [more]
A0A564YU151.273e-5950.56HD domain-containing protein OS=Hymenolepis diminu... [more]
A0A068WS162.768e-5849.46Metal dependent phosphohydrolase HD region OS=Echi... [more]
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BLAST of HD domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
hddc22.057e-5447.28HD domain containing 2 [Source:NCBI gene;Acc:10302... [more]
hddc22.163e-4747.59HD domain containing 2 [Source:NCBI gene;Acc:10302... [more]
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BLAST of HD domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
hddc22.503e-4847.53HD domain containing 2 [Source:NCBI gene;Acc:55412... [more]
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BLAST of HD domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
YGL101W_mRNA4.600e-4037.44Protein of unknown function; non-essential gene; i... [more]
YBR242W_mRNA3.734e-3435.11Putative protein of unknown function; green fluore... [more]
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BLAST of HD domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO471926.399e-6252.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of HD domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
hddc22.140e-5146.74HD domain containing 2 [Source:NCBI gene;Acc:10115... [more]
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BLAST of HD domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000000192.14.781e-169100.00SMESG000000192.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30017732 ID=SMED30017732|Name=HD domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=701bp
TTTTGTTTAAAAATATATAAATACGCACTTGTTAAAATGAACAATTCAGT
TGATTTTTTGTTATTCGTAGGCCAATTAAAGAATACCGTTCGAACTGGTT
GGGTTAATTACGGAGTAAATGATCCTGAAAGTGTATCTGATCACATGTAC
AGAATGGCTTTTATGTCATTTTTATTACCAGCTATAAATCATAACAATGA
AATCAAAGTTGATAATAATCGAATAATGAAAATGGCTTTAATTCATGATT
TAGCAGAATGTATTGTTGGTGACATAACACCGAATTGCGGATATACTAAA
GCTCAAAAATTACAACTGGAAACGGAGGCTATGATTACCATAATGAAAAC
CGTCGGAAAGGAATTATCAAATGAAATAATGGAGCTTTGGAACGAATACA
ATAATCAGGTGACGGAGGAAGCAAAAATTACCAAAGATTTTGATCGATTC
GACATGATTTTACAAGCTTATGAATATGAAAAAAAAGAAAATAAACCAAA
ATTTTTGCAAGATTTTTTCGATAGTACCGAGGGGAAATTTAGCTCAGATC
TCGTAAAAGGTTGGGCGCAAGATTTATACGAGAAAAGGAAATGTTTGATC
GATGAAATAGAAATGACGAAGGAGGACCATTGGAGACCTTCGTACTCTCA
AAATACTAGAACTGGACCTAGTAAATATCGAGTCAACATCCATGTGGAAA
A
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protein sequence of SMED30017732-orf-1

>SMED30017732-orf-1 ID=SMED30017732-orf-1|Name=SMED30017732-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=233bp
FCLKIYKYALVKMNNSVDFLLFVGQLKNTVRTGWVNYGVNDPESVSDHMY
RMAFMSFLLPAINHNNEIKVDNNRIMKMALIHDLAECIVGDITPNCGYTK
AQKLQLETEAMITIMKTVGKELSNEIMELWNEYNNQVTEEAKITKDFDRF
DMILQAYEYEKKENKPKFLQDFFDSTEGKFSSDLVKGWAQDLYEKRKCLI
DEIEMTKEDHWRPSYSQNTRTGPSKYRVNIHVE
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:00029535'-deoxynucleotidase activity
Vocabulary: biological process
TermDefinition
GO:0016311dephosphorylation
GO:0008150biological_process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR003607HD/PDEase_dom
IPR006674HD_domain
Vocabulary: cellular component
TermDefinition
GO:0005575cellular_component