SMED30017615

Overview
NameSMED30017615
Smed IDSMED30017615
Length (bp)1123
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SMED30017615 (SMED30017615) t-SNE clustered cells

Violin plots show distribution of expression levels for SMED30017615 (SMED30017615) in cells (dots) of each of the 12 neoblast clusters.

 

back to top


 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SMED30017615 (SMED30017615) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SMED30017615 (SMED30017615) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top


 

Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020




SMED30017615

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30017615h1SMcG0020915 SmedASXL_009605SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
pharynxSMED30017615h1SMcG0020915 dd_Smed_v4_12216_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Alignments
SMED30017615 aligns in the following genomic locations:
Alignment LocationAlignment Score
v31.009018:5278..6400 -5570
Homology
BLAST of SMED30017615 vs. TrEMBL
Match: R7TCX3 (ANK_REP_REGION domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_207206 PE=4 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 6.808e-12
Identity = 45/150 (30.00%), Postives = 80/150 (53.33%), Query Frame = 3
Query:  222 EDGYTLLQKCVFHGSKSNDFKLFYYLTQQDANPFISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFEYEFQVPKSRFDEFNHR 671
             DG TLL + +   +K    ++F YL ++ ANP  +D    RD +AW        +++ LL    G  ++   D  G T LH AV++ +  IV +IAE M +L +++++ +  G +P LLA  LG ++I+++   +F   + + D+   R
Sbjct:   24 SDGETLLLQALRIDNKKKRKRMFEYLMRRGANPLDTDAKTDRDALAWACSLGRTAEVKSLLVATQGEFDFKRADNQGMTPLHHAVQSMDPDIVTVIAEEMRRLWISLDQIDHRGLTPYLLALKLGLVNISEIL-LDFGASREQADKRTFR 172          
BLAST of SMED30017615 vs. TrEMBL
Match: A0A210QIQ5 (Ankyrin repeat protein OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT05888 PE=4 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 1.125e-11
Identity = 40/157 (25.48%), Postives = 74/157 (47.13%), Query Frame = 3
Query:  204 DFNIHQEDGYTLLQKCVFHGSKSNDFKLFYYLTQQDANPFISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFEYEFQVPKSRFDEFNHRT 674
            D N+    GY++L   +         K+F  L  ++A+P   D    R  + W        +++FL+  F G  + +  D++G T LH A + G   +V M+A    +  L ++  + +G +P L A  LG+ +IT++ + + +    + D F  RT
Sbjct:   84 DVNMRNSYGYSVLVAALHIDDNDQREKMFRTLINRNADPLQKDPKHGRHVLCWACLLGCVNEVKFLMDMFKGDFDLHEKDKEGMTVLHHATQAGQEEVVTMLASEFRRFGLTVDIVDNLGLTPYLHARRLGYTNITRILQDQGRACPGQGDMFTFRT 240          
BLAST of SMED30017615 vs. TrEMBL
Match: K1PX93 (Putative ZDHHC-type palmitoyltransferase 6 OS=Crassostrea gigas OX=29159 GN=CGI_10013542 PE=4 SV=1)

HSP 1 Score: 74.3294 bits (181), Expect = 7.159e-11
Identity = 40/149 (26.85%), Postives = 71/149 (47.65%), Query Frame = 3
Query:  228 GYTLLQKCVFHGSKSNDFKLFYYLTQQDANPFISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFEYEFQVPKSRFDEFNHRT 674
            GY++L   +         K+F YL  ++A+P   D    R  ++W        Q+  LL   NG  +    D +G T LH A + G++ IVR + E   +  L+++  + +G +P L A  LG+ +IT++   E +    + D +  R+
Sbjct:   34 GYSVLVGALHIDCDEKRGKMFRYLLSRNADPKDKDSKHNRSVLSWAAILGRAEQVDMLLNILNGDHDLTDKDTEGMTVLHHATQGGHVGIVRRLVEEFRRFRLSVDVHDNLGLTPYLHAKRLGYKEITEILHKEGRACPGQSDSYTFRS 182          
BLAST of SMED30017615 vs. TrEMBL
Match: A0A1I8H3U2 (ANK_REP_REGION domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014263g2 PE=4 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 2.384e-9
Identity = 39/155 (25.16%), Postives = 76/155 (49.03%), Query Frame = 3
Query:  210 NIHQEDGYTLLQKCVFHGSKSNDFKLFYYLTQQDANPFISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFEYEFQVPKSRFDEFNHRT 674
            ++   DG T L   +  G++    ++F YL    A     D  ++RD + W T      +LR +L+     +N    D  G TY+HLAV +G++  V +I +   +L+++++  +  G +P LL+  LG+  I++  +   +    + D  + R+
Sbjct:  129 SVDPADGKTPLMAALHIGAEKRRQEVFNYLAHHGAVYDGVDDQYRRDLVGWATALGRHEELRDILRDTTEEVNLQYRDALGLTYMHLAVMSGSLPTVEIIIDEFRRLDVSVDMPDAEGITPYLLSRKLGYTRISQCLQQRGRASAHKSDPVSLRS 283          
BLAST of SMED30017615 vs. TrEMBL
Match: A0A267H7D6 (ANK_REP_REGION domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014263g1 PE=4 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 2.427e-9
Identity = 39/155 (25.16%), Postives = 76/155 (49.03%), Query Frame = 3
Query:  210 NIHQEDGYTLLQKCVFHGSKSNDFKLFYYLTQQDANPFISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFEYEFQVPKSRFDEFNHRT 674
            ++   DG T L   +  G++    ++F YL    A     D  ++RD + W T      +LR +L+     +N    D  G TY+HLAV +G++  V +I +   +L+++++  +  G +P LL+  LG+  I++  +   +    + D  + R+
Sbjct:  129 SVDPADGKTPLMAALHIGAEKRRQEVFNYLAHHGAVYDGVDDQYRRDLVGWATALGRHEELRDILRDTTEEVNLQYRDALGLTYMHLAVMSGSLPTVEIIIDEFRRLDVSVDMPDAEGITPYLLSRKLGYTRISQCLQQRGRASAHKSDPVSLRS 283          
BLAST of SMED30017615 vs. Planmine SMEST
Match: SMESG000016882.1 (SMESG000016882.1)

HSP 1 Score: 660.988 bits (1704), Expect = 0.000e+0
Identity = 335/337 (99.41%), Postives = 336/337 (99.70%), Query Frame = 3
Query:   96 MSSLKTNSKWTREKVLDIIEKQNLFELKILQQHKEIDFNIHQEDGYTLLQKCVFHGSKSNDFKLFYYLTQQDANPFISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFEYEFQVPKSRFDEFNHRTXXXXXXXXXXXXXXDRIQWIKERKNFNKICGLDMSEIKLPAIEEKVRDTDKIEVKSHELDSTRDWCYVMKKQESAKEFPTNAINFKAFLPKYMKIYSKQNLPCFIRDKVYDKRSVEIYQIMQQKLFGDKMKRKPNRMSNKKIMF 1106
            MSSLKTNSKWTREKVLDIIEKQNLFELKILQQHKEIDFN HQEDGYTLLQKCVFHGSKSNDFKLFYYLTQQDANPFISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFEYEFQVPKSRFDEFNHRTKTLILQQGLKKKKQDRIQWIKERKNFNKICGLDMSEIKLPAIEEKVRDTDKIEVKSHELDSTRDWCYVMKKQES+KEFPTNAINFKAFLPKYMKIYSKQNLPCFIRDKVYDKRSVEIYQIMQQKLFGDKMKRKPNRMSNKKIMF
Sbjct:    1 MSSLKTNSKWTREKVLDIIEKQNLFELKILQQHKEIDFNFHQEDGYTLLQKCVFHGSKSNDFKLFYYLTQQDANPFISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFEYEFQVPKSRFDEFNHRTKTLILQQGLKKKKQDRIQWIKERKNFNKICGLDMSEIKLPAIEEKVRDTDKIEVKSHELDSTRDWCYVMKKQESSKEFPTNAINFKAFLPKYMKIYSKQNLPCFIRDKVYDKRSVEIYQIMQQKLFGDKMKRKPNRMSNKKIMF 337          
BLAST of SMED30017615 vs. Planmine SMEST
Match: SMESG000046272.1 (SMESG000046272.1)

HSP 1 Score: 64.6994 bits (156), Expect = 2.344e-11
Identity = 31/100 (31.00%), Postives = 56/100 (56.00%), Query Frame = 3
Query:  324 ISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFE 623
            I D  F+RD + W     +  +   ++   N  ++Y   D DGNTYLHLAV + +  +V++I   M    ++ + SN +GF+P +L+  LG  +I+++ +
Sbjct:  134 IQDLIFQRDPLHWCCILSIVMEFEMIVDYLNADVDYTKKDIDGNTYLHLAVMSNSWELVKIILNAMTINGISGDISNSLGFTPYILSRKLGHREISELIQ 233          
BLAST of SMED30017615 vs. Planmine SMEST
Match: SMESG000046261.1 (SMESG000046261.1)

HSP 1 Score: 64.6994 bits (156), Expect = 2.344e-11
Identity = 31/100 (31.00%), Postives = 56/100 (56.00%), Query Frame = 3
Query:  324 ISDQNFKRDTIAWVTFWKLERQLRFLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMNKSNKIGFSPNLLAYYLGFLDITKMFE 623
            I D  F+RD + W     +  +   ++   N  ++Y   D DGNTYLHLAV + +  +V++I   M    ++ + SN +GF+P +L+  LG  +I+++ +
Sbjct:  134 IQDLIFQRDPLHWCCILSIVMEFEMIVDYLNADVDYTKKDIDGNTYLHLAVMSNSWELVKIILNAMTINGISGDISNSLGFTPYILSRKLGHREISELIQ 233          
The following BLAST results are available for this feature:
BLAST of SMED30017615 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
R7TCX36.808e-1230.00ANK_REP_REGION domain-containing protein OS=Capite... [more]
A0A210QIQ51.125e-1125.48Ankyrin repeat protein OS=Mizuhopecten yessoensis ... [more]
K1PX937.159e-1126.85Putative ZDHHC-type palmitoyltransferase 6 OS=Cras... [more]
A0A1I8H3U22.384e-925.16ANK_REP_REGION domain-containing protein OS=Macros... [more]
A0A267H7D62.427e-925.16ANK_REP_REGION domain-containing protein OS=Macros... [more]
back to top
BLAST of SMED30017615 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of SMED30017615 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000016882.10.000e+099.41SMESG000016882.1[more]
SMESG000046272.12.344e-1131.00SMESG000046272.1[more]
SMESG000046261.12.344e-1131.00SMESG000046261.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30017615 ID=SMED30017615|Name=SMED30017615|organism=Schmidtea mediterranea sexual|type=transcript|length=1123bp
TTTACTCAATTAAACAAACAAAAAATGTAAACTGCAAATTTAAACAACCT
AACTGAATTGTTTAAAGCTTAGTTTCATTAAATTGGTGCAAGAAAATGTC
ATCTTTGAAAACAAACAGTAAGTGGACCAGAGAAAAGGTTTTAGACATCA
TTGAAAAACAGAATTTATTTGAATTGAAGATTCTTCAGCAACACAAGGAG
ATTGATTTTAACATTCACCAAGAAGATGGGTATACTCTACTTCAGAAATG
TGTTTTCCACGGATCCAAATCAAACGATTTCAAACTCTTTTATTACCTAA
CCCAGCAAGATGCTAATCCCTTCATTTCAGATCAGAACTTTAAGCGCGAC
ACAATAGCATGGGTTACGTTTTGGAAGTTGGAAAGACAATTAAGATTTTT
ATTAAAGACATTTAACGGTTTCATTAACTACTATACCGATGATAGAGACG
GAAATACGTATCTACATCTCGCGGTTGAAACCGGAAATATCAGAATTGTG
CGAATGATAGCTGAAAGAATGTTTCAATTAAATCTCAACATGAATAAGTC
GAATAAAATCGGATTCAGTCCAAACTTGCTGGCATACTATCTAGGATTTC
TTGACATCACTAAAATGTTCGAGTATGAATTCCAAGTCCCAAAATCCAGA
TTCGATGAATTTAATCATCGGACAAAAACTCTTATTTTACAGCAAGGATT
GAAAAAGAAAAAACAAGACAGAATTCAATGGATAAAAGAAAGAAAGAATT
TCAACAAAATTTGTGGACTAGATATGTCAGAAATTAAGCTGCCAGCAATT
GAAGAAAAGGTCCGTGATACTGATAAAATTGAAGTCAAGAGTCATGAATT
GGATTCGACAAGAGATTGGTGTTATGTCATGAAAAAGCAAGAATCTGCAA
AAGAATTTCCAACAAATGCAATTAATTTCAAAGCTTTCTTACCAAAATAT
ATGAAAATATATTCCAAGCAAAACCTACCGTGTTTTATCCGAGACAAAGT
CTACGATAAAAGGTCTGTGGAGATCTATCAAATCATGCAGCAAAAGTTAT
TCGGAGACAAAATGAAACGAAAACCAAATCGAATGAGTAATAAAAAAATA
ATGTTTTAGTTAGACTTGGTTCA
back to top

protein sequence of SMED30017615-orf-1

>SMED30017615-orf-1 ID=SMED30017615-orf-1|Name=SMED30017615-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=338bp
MSSLKTNSKWTREKVLDIIEKQNLFELKILQQHKEIDFNIHQEDGYTLLQ
KCVFHGSKSNDFKLFYYLTQQDANPFISDQNFKRDTIAWVTFWKLERQLR
FLLKTFNGFINYYTDDRDGNTYLHLAVETGNIRIVRMIAERMFQLNLNMN
KSNKIGFSPNLLAYYLGFLDITKMFEYEFQVPKSRFDEFNHRTKTLILQQ
GLKKKKQDRIQWIKERKNFNKICGLDMSEIKLPAIEEKVRDTDKIEVKSH
ELDSTRDWCYVMKKQESAKEFPTNAINFKAFLPKYMKIYSKQNLPCFIRD
KVYDKRSVEIYQIMQQKLFGDKMKRKPNRMSNKKIMF*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000420parapharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR036770Ankyrin_rpt-contain_sf
IPR002110Ankyrin_rpt
IPR020683Ankyrin_rpt-contain_dom
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002110Ankyrin repeatSMARTSM00248ANK_2acoord: 44..77
e-value: 170.0
score: 10.8
coord: 118..147
e-value: 0.0096
score: 25.1
IPR002110Ankyrin repeatPROSITEPS50088ANK_REPEATcoord: 118..150
score: 9.778
IPR036770Ankyrin repeat-containing domain superfamilyGENE3DG3DSA:1.25.40.20coord: 4..231
e-value: 1.6E-12
score: 49.1
IPR036770Ankyrin repeat-containing domain superfamilySUPERFAMILYSSF48403Ankyrin repeatcoord: 28..175
IPR020683Ankyrin repeat-containing domainPROSITEPS50297ANK_REP_REGIONcoord: 118..175
score: 10.657