Alpha-mannosidase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017604 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2A1 (mannosidase alpha class 2A member 1 [Source:HGNC Symbol;Acc:HGNC:6824]) HSP 1 Score: 691.034 bits (1782), Expect = 0.000e+0 Identity = 407/1061 (38.36%), Postives = 605/1061 (57.02%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRII--YFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSL------KKDKIK-MFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYS--------------ERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNF--IEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPV--HQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEI-------PKLTIHRLKLNCYAGYISEGSCKFLRKKSP--LMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y + F + DGGVWKQGF + Y + L+VFVVPHSH DPGW+KT ++YF+D TQ I N+M+ L ++ KFI +E+ Y KWW+ I +KD VK LI+N QLEIVTGGWVM DEAT HY ++I+QL +GH WL+NN+ P +GWAIDPFG+S M YLL ++G+++M+IQRVHY +KK A K LEF W+Q WD + I CHMMPF+SYD+PHTCGPDP ICCQFDF R+ F CPWG P I NV+ RA MLLDQYRKK+ L+ +L PLGDDFRY EW +Q++NY +L DYMN Q ++ V+I+FG LSD+FD+L ++DK + MFP LSGD F+YADR DHYW+GYFTSRPF K +DRI+ +HLRAAEI+ +L +KYK F S L+ + +RR L LFQHHDA+ GT+K VVVD+ +L +++ +L+ IGNS F I+ D SYS + + N I + RY+ ++N L Q R LV + + T +++ + + ++ Q++ ++ A + + +SF+ +I PL + +IL + S+++ + ++ +++S F +++E + L+NS L + TG ++ + +++N+ F YG R+ SGAYLF+PDG + + + G +Y EV +H ++L+ + G+ ++++ NIVDIRK N EI+M I +D + + F+ D N +Q R T K+P+Q NVYPMT +YI+ D+ ++ LLS QS GV S++N IEV +DR L QDDNRGL + + DN++ + +R+L E +S N E + +VS L++ + + H + N +S L G+ S L LPCD HL+N +T +++ L +HR +C + S+G+ F L++ + + ++ + SLS +I ++ M+I T+ +
Sbjct: 131 MLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRT-KVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKI---NKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLM------------VLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAE-PRYLVVYNPLEQDRISLVSVYVSSPT----VQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEG-----ITLENSFVLLRFDQ-TGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSD-IKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQ----DAKHRLTLLSAQSLGV---------SSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEK----RSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQS-SLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCR--FSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQL 1143
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2A2 (mannosidase alpha class 2A member 2 [Source:HGNC Symbol;Acc:HGNC:6825]) HSP 1 Score: 665.611 bits (1716), Expect = 0.000e+0 Identity = 403/1057 (38.13%), Postives = 592/1057 (56.01%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKY----KYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISD---TYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYG----------LPCDYHLINFKTNINE---IP----KLTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTY 3127
M + E L F + DGGVW+QGF + Y D L+VFVVPHSH DPGWIKT D+Y+ + TQ ILNSM+ L ++P +F+ AEV +F KWW+ I+ ++ V++L+ N QLEI TGGWVM DEA +HY ++I+QL +GH WL+ NL TP +GWA+DPFGYS MPYLL+++ + +M+IQRVHY IKK A++ LEF W+Q WDS++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ NV RA +LLDQYRKK+ L+ N +LVPLGDDFRY +EW Q+ NY +L D+ N + +V+ +FG LSDYFD+L K + FP LSGD FSYADR+DHYWTGY+TSRPF K LDR+L HLR AE++ SL+ + + +Y LS +LL E +RRTL LFQHHDA+ GT+K VVVD+ +LL ++ + V +AA ++ + FD VD+ + + + I + ++ R+V LFN L Q R +V + V++ R ++++ Q + QI+ + A E + + VS + + A + D T SSV I+L+ + S++ + F + +S + + L N ++ + TG ++ + + + + ++++ YG R S++ SGAYLF+PDGE + EG + EVVA + ++L+ + G+ ++DI ++VDIR N E+++ I TD + FF D N FQ R+ K+P+Q N YPM +YI+ D+ +++ L + Q+ GV ++ G +EV LDR L QDDNRGL + L DN+ +RLL E + G S Q + YP + + + N+ L + L G G LPCD+HL+N +T E +P L +HR +C + G +C + K L S+F + + ++ SL+ + D+ + M+I T+
Sbjct: 131 MLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLF-RSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDF---TLLTE----ARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSS-PRFVVLFNPLEQERFSMVS--LLVNSPR--VRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLP--ALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDF-ALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTD-IDSQGIFFTDLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQ----DAQKRLTLHTAQALGV---SSLKDGQ----LEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLE---------RRTVG----SEVQDSHSTSYPSLLSHLTSMYLNAPALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAKNLGFNCTTSQGKVAL-GSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPMEIATF 1145
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2A2 (mannosidase alpha class 2A member 2 [Source:HGNC Symbol;Acc:HGNC:6825]) HSP 1 Score: 665.611 bits (1716), Expect = 0.000e+0 Identity = 403/1057 (38.13%), Postives = 592/1057 (56.01%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKY----KYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISD---TYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYG----------LPCDYHLINFKTNINE---IP----KLTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTY 3127
M + E L F + DGGVW+QGF + Y D L+VFVVPHSH DPGWIKT D+Y+ + TQ ILNSM+ L ++P +F+ AEV +F KWW+ I+ ++ V++L+ N QLEI TGGWVM DEA +HY ++I+QL +GH WL+ NL TP +GWA+DPFGYS MPYLL+++ + +M+IQRVHY IKK A++ LEF W+Q WDS++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ NV RA +LLDQYRKK+ L+ N +LVPLGDDFRY +EW Q+ NY +L D+ N + +V+ +FG LSDYFD+L K + FP LSGD FSYADR+DHYWTGY+TSRPF K LDR+L HLR AE++ SL+ + + +Y LS +LL E +RRTL LFQHHDA+ GT+K VVVD+ +LL ++ + V +AA ++ + FD VD+ + + + I + ++ R+V LFN L Q R +V + V++ R ++++ Q + QI+ + A E + + VS + + A + D T SSV I+L+ + S++ + F + +S + + L N ++ + TG ++ + + + + ++++ YG R S++ SGAYLF+PDGE + EG + EVVA + ++L+ + G+ ++DI ++VDIR N E+++ I TD + FF D N FQ R+ K+P+Q N YPM +YI+ D+ +++ L + Q+ GV ++ G +EV LDR L QDDNRGL + L DN+ +RLL E + G S Q + YP + + + N+ L + L G G LPCD+HL+N +T E +P L +HR +C + G +C + K L S+F + + ++ SL+ + D+ + M+I T+
Sbjct: 131 MLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLF-RSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDF---TLLTE----ARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSS-PRFVVLFNPLEQERFSMVS--LLVNSPR--VRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLP--ALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDF-ALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTD-IDSQGIFFTDLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQ----DAQKRLTLHTAQALGV---SSLKDGQ----LEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLE---------RRTVG----SEVQDSHSTSYPSLLSHLTSMYLNAPALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAKNLGFNCTTSQGKVAL-GSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPMEIATF 1145
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2A2 (mannosidase alpha class 2A member 2 [Source:HGNC Symbol;Acc:HGNC:6825]) HSP 1 Score: 589.726 bits (1519), Expect = 0.000e+0 Identity = 325/777 (41.83%), Postives = 469/777 (60.36%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKY----KYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISD---TYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTD 2341
M + E L F + DGGVW+QGF + Y D L+VFVVPHSH DPGWIKT D+Y+ + TQ ILNSM+ L ++P +F+ AEV +F KWW+ I+ ++ V++L+ N QLEI TGGWVM DEA +HY ++I+QL +GH WL+ NL TP +GWA+DPFGYS MPYLL+++ + +M+IQRVHY IKK A++ LEF W+Q WDS++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ NV RA +LLDQYRKK+ L+ N +LVPLGDDFRY +EW Q+ NY +L D+ N + +V+ +FG LSDYFD+L K + FP LSGD FSYADR+DHYWTGY+TSRPF K LDR+L HLR AE++ SL+ + + +Y LS +LL E +RRTL LFQHHDA+ GT+K VVVD+ +LL ++ + V +AA ++ + FD VD+ + + + I + ++ R+V LFN L Q R +V + V++ R ++++ Q + QI+ + A E + + VS + + A + D T SSV I+L+ + S++ + F + +S + + L N ++ + TG ++ + + + + ++++ YG R S++ SGAYLF+PDGE + EG + EVVA + ++L+ + G+ ++DI ++VDIR N E+++ I TD
Sbjct: 131 MLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLF-RSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDF---TLLTE----ARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSS-PRFVVLFNPLEQERFSMVS--LLVNSPR--VRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLP--ALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDF-ALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTD 891
BLAST of Alpha-mannosidase vs. Ensembl Human
Match: MAN2A2 (mannosidase alpha class 2A member 2 [Source:HGNC Symbol;Acc:HGNC:6825]) HSP 1 Score: 532.332 bits (1370), Expect = 2.084e-174 Identity = 273/571 (47.81%), Postives = 370/571 (64.80%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKY----KYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQIN 1735
M + E L F + DGGVW+QGF + Y D L+VFVVPHSH DPGWIKT D+Y+ + TQ ILNSM+ L ++P +F+ AEV +F KWW+ I+ ++ V++L+ N QLEI TGGWVM DEA +HY ++I+QL +GH WL+ NL TP +GWA+DPFGYS MPYLL+++ + +M+IQRVHY IKK A++ LEF W+Q WDS++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ NV RA +LLDQYRKK+ L+ N +LVPLGDDFRY +EW Q+ NY +L D+ N + +V+ +FG LSDYFD+L K + FP LSGD FSYADR+DHYWTGY+TSRPF K LDR+L HLR AE++ SL+ + + +Y LS +LL E +RRTL LFQHHDA+ GT+K VVVD+ +LL ++ + V +AA ++ + FD VD+ + + + I + ++ R+V LFN L Q R +V + V++ R ++++ Q + QI+
Sbjct: 131 MLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLF-RSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDF---TLLTE----ARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSS-PRFVVLFNPLEQERFSMVS--LLVNSPR--VRVLSEEGQPLAVQIS 688
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-2 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:Q2PJ74]) HSP 1 Score: 605.134 bits (1559), Expect = 0.000e+0 Identity = 373/967 (38.57%), Postives = 539/967 (55.74%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXX-PHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYF--RCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYF---DSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAE------FNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRE---------TSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKV-DGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKE--FGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT 2890
M LY++ F + DGGVWKQG+K+EY E VK + +V PHSH DPGWI T +EY+ T+ IL+ M L ++ M+FI+AE+ +FE WW + K +VK ++ + EIVTGGWVMTDEA AHY SMI +L +GH W++N+L + P + W+IDPFG S MP+LL + I N VIQRVHY +K+ LA K LEF W+Q + S + H+MPF+SYD+PHTCGP+PS+CCQFDF R+ C WG P +I D+NV RAEM+ DQYRKK+ L+ N N + PLGDDFRY + EW+ QY NY KL +YMN + EWNV +FG LSDYF D+ + P+ SGD F+YADR DHYW+GYFTSRPF K LDR+L ++LR+AEI +L+ N + G+ ++ + EK+ +RR LSLFQHHD V GT+K HVV+D+ ++++A+ + + + A +L + N +D + + I N V LFN+LS+ R I I+VD+ G++ + + K Q++P+ E N + F L++GP+ R+ + +T S V I N+ FK + S ++S + +KN + + G I+ L LN F YGAR+S+ +GAYLF+PDGE ++ S + I+ +GE+ +V A IL+ + + GL ID++N VD+R + N+E+++ + V DEFF D N Q I+R+ K+P Q N YPM+ YIE D T ++ + S Q+ GV ++ G IE+ LDR L+ DDNRGL + + DN+ +R++ E SG+ KE G + + L YP+ +M + S+ S V Q+ L CD HL+ F+T
Sbjct: 145 MLDLYDTWKFENPDGGVWKQGWKIEYDAEKVKSLPRLEVIVIPHSHCDPGWIMTFEEYYNRQTRNILDGMAKHLAEKDEMRFIYAEISFFETWWRDQADEIKKKVKGYLEAGKFEIVTGGWVMTDEANAHYHSMITELFEGHEWIQNHLGKSAIPQSHWSIDPFGLSPSMPHLLTSANITNAVIQRVHYSVKRELALKKNLEFYWRQLFGSTGHPDLRSHIMPFYSYDIPHTCGPEPSVCCQFDFRRMPEGGKSCDWGIPPQKINDDNVAHRAEMIYDQYRKKSQLFKN-NVIFQPLGDDFRYDIDFEWNSQYENYKKLFEYMNSKSEWNVHAQFGTLSDYFKKLDTAISASGEQLPTFSGDFFTYADRDDHYWSGYFTSRPFYKQLDRVLQHYLRSAEIAFTLA----NIEEEGMV----EAKIFEKLVTARRALSLFQHHDGVTGTAKDHVVLDYGQKMIDALNACEDILSEALVVLLGIDSTNK------MQMDEHRVNENLLPEKRVYKIGQN----VVLFNTLSRNRN--EPICIQVDSLDAGVE---ADPPIKKQQVSPVIAYDEEKKTLVVKNGIFELCFMLSLGPMESVSFRL----VKNTTTSKVEI---ITNNAAEFK---ETSFKSSSTSGDFTVKNDKVEAEFDGENGMIKRATSLVDDKPIDLNSHFIHYGARKSKRKFANGNEDNPAGAYLFLPDGEARELKKQSSDWIL-VKGEVVQKVFATPNNDLKILQTYTLYQGL--PWIDLDNEVDVRSKENFELALRFSSS-VNSGDEFFTDLNGMQMIKRRRQTKLPTQANFYPMSAGVYIE----DDTTRMSIHSAQALGV---SSLSSGQ----IEIMLDRRLSSDDNRGLQQGVRDNKRTVAHFRIVIEPMSS-SSGNKKEERVGFHSHVGHLATWSLHYPLVKM-IGDATPKSISSKNVEQE-------LNCDLHLVTFRT 1053
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-3 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:O01574]) HSP 1 Score: 422.935 bits (1086), Expect = 2.897e-130 Identity = 292/982 (29.74%), Postives = 496/982 (50.51%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK----DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIK----IMGSGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLF-IPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEP----LVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGL--PCDYHLINFKTNINEIPKLTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPE 3091
P +H+DPGW++T + Y K Q IL++M F++K M+F+ AE V+FE+WW+ ++ K+ VKKL+ +LE+ TG WVMTDEA ++ ++ + +G ++ N P T W+ DPFGYS +PYL KKSG++ VI R+H+ +K+ L S K + F+W+Q++D+ + + ++P+ YD+ ++CG D S+CC+FDF R+ ++ CP G P +IT+ NV +AE L++Q K + +Y +L+ GDDFR+ +EW+ Q+ N+I + D +NK VEI+FG +DYF+ L+K +K P++SGD F Y YWTGY+T+RPF K R+L + +R +I+LS+ + + K G + ++++ +RR L+LFQHHDA+ GTSK V+ ++ ++LL+A + + I+ N+ S D+D + + ++++ E+ + +FNS H+ D +I +K I+ ++I+ Q+ P FQ ++ + + F+ + PL+ +V++ G S I + N+ + ++ ++S S N L+ K+ + TG I+ V L SK+ +F Y GAYL + IIE+ L G L + ++ L + V+G +DI +DI KE N E+ T + P + DS Q +RR F K+P+Q N YPM A+ ++S +++ ++S +G R ++ +E+ +DRILNQDD +GL +D + V ++L+F D + +N + + + Q + +IYP MF N P + + L PCD L+ + + L ++R C + + G+C K S + + + K V K LSG +G +K E
Sbjct: 143 PFTHVDPGWLETFERYTKSTNQ-ILDNMHQFMMKNEKMRFMWAEFVFFERWWSLQNEQVKEDVKKLVTEGRLELATGSWVMTDEANPYFPVSVDNIVEGFQFIHKNFGIKPQTMWSNDPFGYSNSVPYLFKKSGVHRTVINRIHHKLKQTLQSQKAIPFKWRQYFDATGEDDVLTQILPYTHYDILNSCGSDASVCCEFDFKRMTHWSCP-GPKPEKITNANVAAKAEKLVNQLEKMSEMY-KAPVILMMHGDDFRFDMIEEWNQQHDNFIPVFDEINKGSR--VEIRFGTFTDYFNDLEKWYSNNKDSEPPTVSGDFFPYMCALGDYWTGYYTTRPFFKRQGRLLHSLIRNGDIMLSMLRVNLKQRKIGENV--------KRLEAARRNLALFQHHDAITGTSKVSVMDNY-SELLHA--------SIVSTNIVLENLTKS-------DIDLYPRIHDGIELQTIVDLESS-EKEIRIFNS---------HLFEITDVFKIRVKEREVIVSIDGKIIEAQLEPFFQKSKVEKDSFLLLFQATVLPLSMMKVKV-QRGDSGGLTKMAKIEAKDT-NAWDLGSSWTIASSTSAPN----LETPYFKVSNDPITGAIQSVNKLSDNSKFHCQQSFYNY----KEAGGGAYLMRLHTNPKEIIEYQWLKV----SGPLRQSIYQKSTNVLQRLSIHNVEGPSGEEVDISMSIDITKERNTELMTRFSTKWDKPLT--YTDSVGMQLLRRD-FYKLPVQSNYYPMPTAAVLQS----GKQRLSIVSNVEHGARFLES-------GTVEINIDRILNQDDGKGLGTGPDAIPIDMKPVDMKFKLIF-DSLESDPTENSRYSTHSFRAQQAVQTIIYP-PMMF------NRPPKKEEDIEEIEEISNLKFPCDIQLLTVRPLEDNKQLLILYRHATVCSSQKV--GNCGGELKSS--LMDLLIKLGAKQVQKTDLSGVTRVGGIIKVE 1045
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-1 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:Q20829]) HSP 1 Score: 223.402 bits (568), Expect = 5.593e-60 Identity = 227/851 (26.67%), Postives = 375/851 (44.07%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYF---KDDTQP-----ILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWD-SENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPV----EITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLS---GDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEK-IDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF---VSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSR--ETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLF-SHILKLFKVDGLLSHTIDIENIVD-IRKESNYEISMVIKTDF---VAPSDEFFVDSNCFQFIRR--------KTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPL 2632
PH+H D GWIKTVD+YF K + P I N+++D L+K P+ +F AE + +W+ + S + Q++KL+KN Q+EI+ GGWV DEAT+HY +I+Q+ G L+ P TGW IDPFG+S+ M + ++ G +++ R+HY+ K+ +K LEF W D ++NK FF+ GP C +D + C G+DP+ I NVK + + +D + +A + + N V++ +G DF+Y W Y N KL+ Y+N V + + + Y +++ P+LS D F YA + YWTGYFTSRP K + +R A +L L+ L + N + I+ R +L QHHDAV GT+K +V D++ QL + + V +++ + + D N+ I + E V +FNS + + IP T + + +++ QI FQ+ + + + + + PL + V + + +H N +K F + E + N+Y++ + GY+ + + +K K + F Y S+ + SGAY+F P + I L V G + +EV + F S ++L + + I+ E IV I KE+ I+ T + V ++ F DSN Q + R + D PI GN YP+T YI+ D + +++ ++ G+ + +E+ L R DD+ G+ E L
Sbjct: 42 PHTHDDLGWIKTVDQYFWGAKPELVPVGVQYIYNTVIDELLKNPDRRFSFAETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGGGWVQNDEATSHYVDIIDQMTLGLQRLEQIFGECGKPVTGWQIDPFGHSREMANIYREMGYSSVYFARIHYLEKQIRLKNKTLEFMWNTSDDITDNKLFTGA----FFN----DNYGPPEGFC--WDSL------C--GDDPIMDNLNIEGYNVKEKVDAFVDHVKNQA-AHQSTNQVMLLMGSDFQYTNANSW---YVNLDKLIKYVNADTSKKVRVIYSTPACYTKAVQAKT----PTLSVKHDDFFPYASGRHSYWTGYFTSRPAFKGM-------IRQASCMLQLA--------KQLDVIANLGPEDDSDIEILREASALVQHHDAVTGTAKENVTRDYEKQLAKGVSEVEVVINDFMKKMNPDGL------------DPKLVLCPLINETICKPINGSSEFSVVIFNSNGRYFNGTIRIPYSQKT----AVLRDAHKNVLESQIVETFQIDQLKDTDRLPYEIHVFVRVPPLGYTTVFV------EKGSKPERVHFNN-------RKKFNTNVE--IQNEYLIAG--------FDSQGYLSYITEKATKKKRSIRQEFFYYEGIDSKDDQPSGAYIFRPKTQQPIALTSKLALEV-VPGAIINEVRQKVSPFVSQQIRLPRG----KNYIEFEWIVGPIPKETKNPITKEFVTRYTTEVHSKNQSFTDSNGRQAMERFFDGATSFEYSDTEPIAGNYYPITSFGYIK----DENAQFSVITDRAQGMVASDGV--------VEIMLHRRCFYDDHFGVEEAL 795
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-1 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:Q20829]) HSP 1 Score: 223.402 bits (568), Expect = 5.593e-60 Identity = 227/851 (26.67%), Postives = 375/851 (44.07%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYF---KDDTQP-----ILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWD-SENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPV----EITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLS---GDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEK-IDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF---VSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSR--ETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLF-SHILKLFKVDGLLSHTIDIENIVD-IRKESNYEISMVIKTDF---VAPSDEFFVDSNCFQFIRR--------KTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPL 2632
PH+H D GWIKTVD+YF K + P I N+++D L+K P+ +F AE + +W+ + S + Q++KL+KN Q+EI+ GGWV DEAT+HY +I+Q+ G L+ P TGW IDPFG+S+ M + ++ G +++ R+HY+ K+ +K LEF W D ++NK FF+ GP C +D + C G+DP+ I NVK + + +D + +A + + N V++ +G DF+Y W Y N KL+ Y+N V + + + Y +++ P+LS D F YA + YWTGYFTSRP K + +R A +L L+ L + N + I+ R +L QHHDAV GT+K +V D++ QL + + V +++ + + D N+ I + E V +FNS + + IP T + + +++ QI FQ+ + + + + + PL + V + + +H N +K F + E + N+Y++ + GY+ + + +K K + F Y S+ + SGAY+F P + I L V G + +EV + F S ++L + + I+ E IV I KE+ I+ T + V ++ F DSN Q + R + D PI GN YP+T YI+ D + +++ ++ G+ + +E+ L R DD+ G+ E L
Sbjct: 42 PHTHDDLGWIKTVDQYFWGAKPELVPVGVQYIYNTVIDELLKNPDRRFSFAETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGGGWVQNDEATSHYVDIIDQMTLGLQRLEQIFGECGKPVTGWQIDPFGHSREMANIYREMGYSSVYFARIHYLEKQIRLKNKTLEFMWNTSDDITDNKLFTGA----FFN----DNYGPPEGFC--WDSL------C--GDDPIMDNLNIEGYNVKEKVDAFVDHVKNQA-AHQSTNQVMLLMGSDFQYTNANSW---YVNLDKLIKYVNADTSKKVRVIYSTPACYTKAVQAKT----PTLSVKHDDFFPYASGRHSYWTGYFTSRPAFKGM-------IRQASCMLQLA--------KQLDVIANLGPEDDSDIEILREASALVQHHDAVTGTAKENVTRDYEKQLAKGVSEVEVVINDFMKKMNPDGL------------DPKLVLCPLINETICKPINGSSEFSVVIFNSNGRYFNGTIRIPYSQKT----AVLRDAHKNVLESQIVETFQIDQLKDTDRLPYEIHVFVRVPPLGYTTVFV------EKGSKPERVHFNN-------RKKFNTNVE--IQNEYLIAG--------FDSQGYLSYITEKATKKKRSIRQEFFYYEGIDSKDDQPSGAYIFRPKTQQPIALTSKLALEV-VPGAIINEVRQKVSPFVSQQIRLPRG----KNYIEFEWIVGPIPKETKNPITKEFVTRYTTEVHSKNQSFTDSNGRQAMERFFDGATSFEYSDTEPIAGNYYPITSFGYIK----DENAQFSVITDRAQGMVASDGV--------VEIMLHRRCFYDDHFGVEEAL 795
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Match: aman-1 (Alpha-mannosidase [Source:UniProtKB/TrEMBL;Acc:Q20829]) HSP 1 Score: 223.402 bits (568), Expect = 5.593e-60 Identity = 227/851 (26.67%), Postives = 375/851 (44.07%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYF---KDDTQP-----ILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWD-SENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPV----EITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLS---GDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEK-IDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF---VSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSR--ETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLF-SHILKLFKVDGLLSHTIDIENIVD-IRKESNYEISMVIKTDF---VAPSDEFFVDSNCFQFIRR--------KTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPL 2632
PH+H D GWIKTVD+YF K + P I N+++D L+K P+ +F AE + +W+ + S + Q++KL+KN Q+EI+ GGWV DEAT+HY +I+Q+ G L+ P TGW IDPFG+S+ M + ++ G +++ R+HY+ K+ +K LEF W D ++NK FF+ GP C +D + C G+DP+ I NVK + + +D + +A + + N V++ +G DF+Y W Y N KL+ Y+N V + + + Y +++ P+LS D F YA + YWTGYFTSRP K + +R A +L L+ L + N + I+ R +L QHHDAV GT+K +V D++ QL + + V +++ + + D N+ I + E V +FNS + + IP T + + +++ QI FQ+ + + + + + PL + V + + +H N +K F + E + N+Y++ + GY+ + + +K K + F Y S+ + SGAY+F P + I L V G + +EV + F S ++L + + I+ E IV I KE+ I+ T + V ++ F DSN Q + R + D PI GN YP+T YI+ D + +++ ++ G+ + +E+ L R DD+ G+ E L
Sbjct: 42 PHTHDDLGWIKTVDQYFWGAKPELVPVGVQYIYNTVIDELLKNPDRRFSFAETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGGGWVQNDEATSHYVDIIDQMTLGLQRLEQIFGECGKPVTGWQIDPFGHSREMANIYREMGYSSVYFARIHYLEKQIRLKNKTLEFMWNTSDDITDNKLFTGA----FFN----DNYGPPEGFC--WDSL------C--GDDPIMDNLNIEGYNVKEKVDAFVDHVKNQA-AHQSTNQVMLLMGSDFQYTNANSW---YVNLDKLIKYVNADTSKKVRVIYSTPACYTKAVQAKT----PTLSVKHDDFFPYASGRHSYWTGYFTSRPAFKGM-------IRQASCMLQLA--------KQLDVIANLGPEDDSDIEILREASALVQHHDAVTGTAKENVTRDYEKQLAKGVSEVEVVINDFMKKMNPDGL------------DPKLVLCPLINETICKPINGSSEFSVVIFNSNGRYFNGTIRIPYSQKT----AVLRDAHKNVLESQIVETFQIDQLKDTDRLPYEIHVFVRVPPLGYTTVFV------EKGSKPERVHFNN-------RKKFNTNVE--IQNEYLIAG--------FDSQGYLSYITEKATKKKRSIRQEFFYYEGIDSKDDQPSGAYIFRPKTQQPIALTSKLALEV-VPGAIINEVRQKVSPFVSQQIRLPRG----KNYIEFEWIVGPIPKETKNPITKEFVTRYTTEVHSKNQSFTDSNGRQAMERFFDGATSFEYSDTEPIAGNYYPITSFGYIK----DENAQFSVITDRAQGMVASDGV--------VEIMLHRRCFYDDHFGVEEAL 795
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: alpha-Man-IIa (gene:FBgn0011740 transcript:FBtr0334302) HSP 1 Score: 584.334 bits (1505), Expect = 0.000e+0 Identity = 339/937 (36.18%), Postives = 530/937 (56.56%), Query Frame = 2
Query: 47 IINFNY*MTKLYESLDFTDNDGGVWKQGFKVEY-AMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYF--RCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSL---KKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRIL-QNNIGNSQFDQIIFDVDNLK---SYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQL----------AEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQ-LKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTN 2794
+ N + M +LY+ + F D DGGVWKQG+ ++Y ++ KLKVFVVPHSH DPGWI+T +EY++ DT+ IL++ L L P MKFI AE+ YF ++++ + +N+K Q+K ++KN QLE VTGGWVM DEA +H+ +++ QL +G +WLK +N TPT WAIDPFG+S MPY+L+KSG NM+IQR HY +KK LA +QLEF W+Q WD++ ++ HMMPF+SYD+PHTCGPDP +CCQFDF R+ F CPW P I+D+NV R+++L+DQ++KKA LY N +L+PLGDDFR+K EW +Q NY +L +++N Q +NV+ +FG L +YFD++ ++ FP+LSGD F+YADR D+YW+GY+TSRP+ K +DR+LM+++RAAE++ + +H + + + E+++ +RR LSLFQHHD + GT+K HVVVD++ ++ A+K Q V + R+L + +I + F F +D+ + S E + ++V + N+L R+ LV + + + N ++ Q++P++ + + ++ + FK + P+ +L S +S +L KN + + + L+ S G ++ ++ ++ F KYG R + SGAYLF+P+G S +E +V +G+L V L S + + G +I N+VDI N EI M ++T + D F+ D N QFI+R+ DK+P+Q N YP+ +IE D+ ++ LL+ Q G G ++ G +E+ DR L DD RGL + ++DN+ V YRL+ E ++ + G T ++++ L+ P+ + N
Sbjct: 102 VPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRT-NVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSA----WH--------SWDGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPF----VSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLA-TYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLV-TKGKLESSVSV--GLPSVVHQTIMRGG----APEIRNLVDIGSLDNTEIVMRLET-HIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIE----DANTRLTLLTGQPLG---GSSLASGE----LEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSELHPAGYLTSAAHKASQSLLDPLDKFIFAEN 1001
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: alpha-Man-IIa (gene:FBgn0011740 transcript:FBtr0082031) HSP 1 Score: 584.334 bits (1505), Expect = 0.000e+0 Identity = 339/937 (36.18%), Postives = 530/937 (56.56%), Query Frame = 2
Query: 47 IINFNY*MTKLYESLDFTDNDGGVWKQGFKVEY-AMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYF--RCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSL---KKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRIL-QNNIGNSQFDQIIFDVDNLK---SYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQL----------AEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQ-LKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTN 2794
+ N + M +LY+ + F D DGGVWKQG+ ++Y ++ KLKVFVVPHSH DPGWI+T +EY++ DT+ IL++ L L P MKFI AE+ YF ++++ + +N+K Q+K ++KN QLE VTGGWVM DEA +H+ +++ QL +G +WLK +N TPT WAIDPFG+S MPY+L+KSG NM+IQR HY +KK LA +QLEF W+Q WD++ ++ HMMPF+SYD+PHTCGPDP +CCQFDF R+ F CPW P I+D+NV R+++L+DQ++KKA LY N +L+PLGDDFR+K EW +Q NY +L +++N Q +NV+ +FG L +YFD++ ++ FP+LSGD F+YADR D+YW+GY+TSRP+ K +DR+LM+++RAAE++ + +H + + + E+++ +RR LSLFQHHD + GT+K HVVVD++ ++ A+K Q V + R+L + +I + F F +D+ + S E + ++V + N+L R+ LV + + + N ++ Q++P++ + + ++ + FK + P+ +L S +S +L KN + + + L+ S G ++ ++ ++ F KYG R + SGAYLF+P+G S +E +V +G+L V L S + + G +I N+VDI N EI M ++T + D F+ D N QFI+R+ DK+P+Q N YP+ +IE D+ ++ LL+ Q G G ++ G +E+ DR L DD RGL + ++DN+ V YRL+ E ++ + G T ++++ L+ P+ + N
Sbjct: 101 VPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRT-NVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSA----WH--------SWDGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPF----VSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLA-TYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLV-TKGKLESSVSV--GLPSVVHQTIMRGG----APEIRNLVDIGSLDNTEIVMRLET-HIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIE----DANTRLTLLTGQPLG---GSSLASGE----LEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSELHPAGYLTSAAHKASQSLLDPLDKFIFAEN 1000
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: alpha-Man-IIb (gene:FBgn0026616 transcript:FBtr0334593) HSP 1 Score: 430.254 bits (1105), Expect = 2.860e-131 Identity = 340/1142 (29.77%), Postives = 537/1142 (47.02%), Query Frame = 2
Query: 119 WKQGFKVEYAME--DXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFW------DSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDY-MNKQKEWNVEIKFGILSDYFDSLK---KDKIKMFPSLSGDMFSYAD----RQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLS-TVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLL----NAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQ-TNGERYV----------------------YLFNSLSQPRQLLVHIPIEVDTERI---GIKIMG-SGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVH---IHLYNIK-NSMNFKKNFQV---------------------SSENSLLNKY------VVLKNSLKKLHINSTTGYIELVEDLYSKSK----YKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLN-----TIVHFEGELYDEV-VAENKLFSHILKLFKVDGLLSHTIDIENIVDIR-----KESNYEISMVIKTDFVA-----------PSDE--------FFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDN----KEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT----NINEIPK----LTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPE----------DICMNLMDIDTYAVHF 3139
W +GF+ + + D ++ LK+ VVPHSH DPGW+KT YF+ D++ ILN ++ + + +M FI +E+ + + WW+ ++ +K+LI ++EI TGGWVMTDEA H M++QL +GH WLKNNLN TP GW+IDPFG+ +PYLL + +IQR+HY K+ A + +F WK +W DSE S+ H MPF Y + +CGP P IC FDF +I + ITD+N++ +A++LL+QY + A L+ + N L+P+GDDFRY ++E QY+NY KL+D+ M ++ +N +I+FG SDYF+++K KD FP+ GD F Y+D + YW+GYFT+RPF K+L L + LR+AEIV +L+ + K + ++ ++ +E I +RR L LFQHHDA+ GTSKA V+ D+ +L N +KM + Q+ + G F F+ DN + + IQ NG+ L+NSL+Q R +EV T R+ +KI+ G +L QINP++ + + S +G R+R + + + + Y ++ + +NFK+N SS S+ + L+N +L + +G+++ + K + + NI F Y R ++ SGAYLF D E S E + L I+ G + +V V +H +++F L I +EN +D +E+ + V D +A P D F+ D N FQ+ R I I+GN +P+T ++I+ DS ++ LL+ + G + G +EV LDR DD RG+ E +VD+ + + LL ED L G + + + + QL N L YP + FV + + L+ LL LPCD HL +T + P L +HR +C +S G + PL +V + ++ ++ + G + K +I + M++ T+ + F
Sbjct: 148 WDRGFEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAG-SLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFITDDNLESKAQLLLEQYARTASLFPH-NVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYFEAIKERMKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIVFTLAYNTARQAKRENAIKIYEKN--YELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHHG---FLLSEFERDNFNKLPRK------MPIQMANGDESTPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKR-------LEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITDTYEQGLGTSVSGTVG-----RIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIYCDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQCNIKFAAY--RSAQFHSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQ----DSRLRLTLLTTHAQG---AASYEPGQ----LEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVED---LPGGQHVTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLEQPELAAALLPLVRLLPKGPLPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFDC---SVSAGRELSMEAICPLSSKGLGNVQLGRLSLHTIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNLTF 1245
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: alpha-Man-IIb (gene:FBgn0026616 transcript:FBtr0345238) HSP 1 Score: 430.254 bits (1105), Expect = 2.860e-131 Identity = 340/1142 (29.77%), Postives = 537/1142 (47.02%), Query Frame = 2
Query: 119 WKQGFKVEYAME--DXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFW------DSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDY-MNKQKEWNVEIKFGILSDYFDSLK---KDKIKMFPSLSGDMFSYAD----RQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLS-TVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLL----NAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQ-TNGERYV----------------------YLFNSLSQPRQLLVHIPIEVDTERI---GIKIMG-SGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVH---IHLYNIK-NSMNFKKNFQV---------------------SSENSLLNKY------VVLKNSLKKLHINSTTGYIELVEDLYSKSK----YKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLN-----TIVHFEGELYDEV-VAENKLFSHILKLFKVDGLLSHTIDIENIVDIR-----KESNYEISMVIKTDFVA-----------PSDE--------FFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDN----KEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT----NINEIPK----LTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPE----------DICMNLMDIDTYAVHF 3139
W +GF+ + + D ++ LK+ VVPHSH DPGW+KT YF+ D++ ILN ++ + + +M FI +E+ + + WW+ ++ +K+LI ++EI TGGWVMTDEA H M++QL +GH WLKNNLN TP GW+IDPFG+ +PYLL + +IQR+HY K+ A + +F WK +W DSE S+ H MPF Y + +CGP P IC FDF +I + ITD+N++ +A++LL+QY + A L+ + N L+P+GDDFRY ++E QY+NY KL+D+ M ++ +N +I+FG SDYF+++K KD FP+ GD F Y+D + YW+GYFT+RPF K+L L + LR+AEIV +L+ + K + ++ ++ +E I +RR L LFQHHDA+ GTSKA V+ D+ +L N +KM + Q+ + G F F+ DN + + IQ NG+ L+NSL+Q R +EV T R+ +KI+ G +L QINP++ + + S +G R+R + + + + Y ++ + +NFK+N SS S+ + L+N +L + +G+++ + K + + NI F Y R ++ SGAYLF D E S E + L I+ G + +V V +H +++F L I +EN +D +E+ + V D +A P D F+ D N FQ+ R I I+GN +P+T ++I+ DS ++ LL+ + G + G +EV LDR DD RG+ E +VD+ + + LL ED L G + + + + QL N L YP + FV + + L+ LL LPCD HL +T + P L +HR +C +S G + PL +V + ++ ++ + G + K +I + M++ T+ + F
Sbjct: 148 WDRGFEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAG-SLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFITDDNLESKAQLLLEQYARTASLFPH-NVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYFEAIKERMKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIVFTLAYNTARQAKRENAIKIYEKN--YELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHHG---FLLSEFERDNFNKLPRK------MPIQMANGDESTPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKR-------LEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITDTYEQGLGTSVSGTVG-----RIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIYCDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQCNIKFAAY--RSAQFHSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQ----DSRLRLTLLTTHAQG---AASYEPGQ----LEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVED---LPGGQHVTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLEQPELAAALLPLVRLLPKGPLPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFDC---SVSAGRELSMEAICPLSSKGLGNVQLGRLSLHTIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNLTF 1245
BLAST of Alpha-mannosidase vs. Ensembl Fly
Match: alpha-Man-IIb (gene:FBgn0026616 transcript:FBtr0083179) HSP 1 Score: 430.254 bits (1105), Expect = 2.860e-131 Identity = 340/1142 (29.77%), Postives = 537/1142 (47.02%), Query Frame = 2
Query: 119 WKQGFKVEYAME--DXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFW------DSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDY-MNKQKEWNVEIKFGILSDYFDSLK---KDKIKMFPSLSGDMFSYAD----RQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLS-TVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLL----NAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQ-TNGERYV----------------------YLFNSLSQPRQLLVHIPIEVDTERI---GIKIMG-SGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVH---IHLYNIK-NSMNFKKNFQV---------------------SSENSLLNKY------VVLKNSLKKLHINSTTGYIELVEDLYSKSK----YKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLN-----TIVHFEGELYDEV-VAENKLFSHILKLFKVDGLLSHTIDIENIVDIR-----KESNYEISMVIKTDFVA-----------PSDE--------FFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDN----KEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT----NINEIPK----LTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPE----------DICMNLMDIDTYAVHF 3139
W +GF+ + + D ++ LK+ VVPHSH DPGW+KT YF+ D++ ILN ++ + + +M FI +E+ + + WW+ ++ +K+LI ++EI TGGWVMTDEA H M++QL +GH WLKNNLN TP GW+IDPFG+ +PYLL + +IQR+HY K+ A + +F WK +W DSE S+ H MPF Y + +CGP P IC FDF +I + ITD+N++ +A++LL+QY + A L+ + N L+P+GDDFRY ++E QY+NY KL+D+ M ++ +N +I+FG SDYF+++K KD FP+ GD F Y+D + YW+GYFT+RPF K+L L + LR+AEIV +L+ + K + ++ ++ +E I +RR L LFQHHDA+ GTSKA V+ D+ +L N +KM + Q+ + G F F+ DN + + IQ NG+ L+NSL+Q R +EV T R+ +KI+ G +L QINP++ + + S +G R+R + + + + Y ++ + +NFK+N SS S+ + L+N +L + +G+++ + K + + NI F Y R ++ SGAYLF D E S E + L I+ G + +V V +H +++F L I +EN +D +E+ + V D +A P D F+ D N FQ+ R I I+GN +P+T ++I+ DS ++ LL+ + G + G +EV LDR DD RG+ E +VD+ + + LL ED L G + + + + QL N L YP + FV + + L+ LL LPCD HL +T + P L +HR +C +S G + PL +V + ++ ++ + G + K +I + M++ T+ + F
Sbjct: 148 WDRGFEERFDAQKKDKQRPPLKIIVVPHSHNDPGWLKTFTNYFQSDSRQILNLLVTKMQEYTDMTFIWSEISFLQLWWDQAHPTKQRALKRLIDAGRIEITTGGWVMTDEANVHIYPMLDQLIEGHQWLKNNLNVTPKVGWSIDPFGHGSTVPYLLSGANFEGTIIQRIHYAWKQWFARQQSGDFIWKPYWRSRKDKDSEAG-SLLTHNMPFDIYSIKGSCGPHPFICLNFDFRKIPGEYTEYSVKAQFITDDNLESKAQLLLEQYARTASLFPH-NVALIPVGDDFRYNKDREVDQQYQNYKKLIDHIMANRRLYNADIRFGTPSDYFEAIKERMKDHTPGFPTFKGDFFVYSDIFSEGRPAYWSGYFTTRPFYKLLSSELEHQLRSAEIVFTLAYNTARQAKRENAIKIYEKN--YELIINARRNLGLFQHHDAITGTSKAAVMRDYAMRLFESTQNMVKMQESCLELLLQKGQPRHHG---FLLSEFERDNFNKLPRK------MPIQMANGDESTPTVPAGEGGAGGSSSSGSVGSFVLYNSLAQKR-------LEVVTLRVQHPNVKIVNDKGVELNHIQINPVWNITDTYEQGLGTSVSGTVG-----RIRTSTRQFEVMFVAELEPLSLSTYRVQVDEVNFKRNIATIYCDDCTESQPASVSPPEEIESSPTSVFEARGKPAGDIQLENPHMRLLFDEKSGFLKTITRKNQKKELLKPLQCNIKFAAY--RSAQFHSGAYLFKTDPEQSEAEKEVLEGYTDMRIIITSGPIASDVTVIYGPFLAHTVRIFNTRTHLDAAIYVENDIDFEPPPKNRETELFMRFVTNIDNIAQAPMQRDPLKEPVDAATMPELPVFYSDQNGFQYHERIKVPAIGIEGNYFPITSGAFIQ----DSRLRLTLLTTHAQG---AASYEPGQ----LEVMLDRRTLYDDYRGMGEGVVDSRLTRHKFWLLVED---LPGGQHVTQPPSYKVLSQQAQQLANALRYPPNLYFVSNLEQPELAAALLPLVRLLPKGPLPCDVHLTTLRTLSDPELQLFPSASALLVLHRQGFDC---SVSAGRELSMEAICPLSSKGLGNVQLGRLSLHTIEATSLTGTEQKSSRESYHIRSLAEISLEPMELRTFNLTF 1245
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2a1 (mannosidase, alpha, class 2A, member 1 [Source:ZFIN;Acc:ZDB-GENE-060526-31]) HSP 1 Score: 697.582 bits (1799), Expect = 0.000e+0 Identity = 400/1056 (37.88%), Postives = 601/1056 (56.91%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK----DKIKM------FPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF-VSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVS------SYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT--------NINEIPKLTIHRLKLNCYAGYISEGS---CKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y+ L F + DGGVWKQGF + Y + L+VFVVPHSH DPGW+KT D+Y++D TQ ILN+M+ L ++ K I +E+ YF KWW++I ++D V++L++N QLE+ TGGWVM DEA AHY +MI+QL +GH WL+ NL P TGWA+DPFG++ YLLK +G++NM+IQRVHY +KK +S K LEF W+Q WD ++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P ITD NV+ RA+ LLDQYRKK+ L+ +L PLGDDFRY EW Q+ NY KL DYMN E +V+ +FG +SDYF +L+K D + M P +SGD F+YADR DHYW+GYFTSRPF K +DR+L ++LRAAE++ SL+L N KYG + + ++ + +RR L LFQHHDA+AGT K VVVD+ +L ++I + V +A ++ + D + +D+++ + + N + + R + + N L Q R +V + + ++++ + Q+++ Q++ +++ A F +SF + PL +++ T S + S + ++F+ ++ VV++N +L I+ TG +E + +S++++ + F YG S++ SGAYLF+PD E +I I +G L+ EV +H L+L+ G+ +++I N VDIR E+N EI+M I +D + D FF D N +Q RKT K+P+Q N YPMT Y++ DS+ ++ LL+ QS G K+ +EV +DR LNQDDNRGL + ++DN++ + +RLL E K++ +N+ ++ SY +N +P+ M V + PS +V L + PCD HL+N + +E L +HR +C G+ + + C R K L K + D+ +K + SLS + + +P++I + M+I TY +
Sbjct: 129 MLDVYDLLRFDNPDGGVWKQGFDISYQENEWDNEPLQVFVVPHSHNDPGWLKTFDDYYRDQTQHILNNMVVKLHEDSRRKMIWSEISYFAKWWDSIDGQKQDAVRRLVENGQLEVATGGWVMPDEANAHYFAMIDQLVEGHQWLERNLGVKPKTGWAVDPFGHTATQAYLLKLAGLSNMLIQRVHYSVKKHFSSQKTLEFFWRQNWDQDSSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRISCPWRIPPQAITDNNVQERAQTLLDQYRKKSKLFRT-KVLLAPLGDDFRYTEAVEWDQQFENYQKLFDYMNSHPELHVKAQFGTISDYFQALRKSTGMDPVGMNVGHLALPVVSGDFFTYADRDDHYWSGYFTSRPFYKRMDRMLESYLRAAEVLYSLTLA--NIQKYGQPSDYPAGENYKLLTEARRNLGLFQHHDAIAGTGKDWVVVDYGTRLFHSILNVKRVIVSSAHWLVLKDKQTYHNDPSKAFLQMDDVQQSQDALPRKNVLEVH-GKPRLLVVSNPLEQARTSMVTVYVNTPN----VRVVSALGQVVRAQVSAVWKDASHATADVFQLSFVAHAAPLGLSVYQLIEVMEPRTDASKYMFLQEGRQLSDSKLEHFRQFYQDD--GAPVVIENPHLRLSISGATGLLEKMMLKEDESEHQMKVEFVWYGTTSSKDKSGAYLFLPDKEATIYSPSQPPVIRVTKGTLFSEVTTTFAHITHTLRLYNTQGVEGQSVEICNTVDIRGETNREIAMRITSDLNS-KDRFFTDLNGYQVQPRKTMAKLPLQANFYPMTSMLYLQ----DSSARLSLLTAQSLGAASLKS-------GQLEVIMDRRLNQDDNRGLGQGVLDNKITANSFRLLLE--KRISVEENEATAPYSYPSILSHMSYMYLN---HPLISMAVSQHL--EAPS-VVPYSPLKASF--PCDMHLVNLRAIQSKEEGGAASEQAALILHRKGFDC--GFSNRNTGLLCTSTRGKIDLEK-LLTDLKVKSITPVSLSLMHTLSSESRPQEISLKAMEIRTYRLEL 1149
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2a2 (mannosidase, alpha, class 2A, member 2 [Source:ZFIN;Acc:ZDB-GENE-110331-1]) HSP 1 Score: 674.47 bits (1739), Expect = 0.000e+0 Identity = 391/983 (39.78%), Postives = 564/983 (57.38%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYK--YGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQI--IFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISD-TYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPV--HQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT--------NINEIPKLTIHRLKLNC 2941
M +Y L+F + DGGVWKQGF++ Y + L+VFVVPHSH DPGWIKT D+Y+ D TQ ILN+M+ + ++P KFI +E+ YF KWW + ++++ ++KLI + QLE+VTGGWVMTDEA AHY +MI+QL +GH WL+ NL TP +GWA+DPFG+S MPYLLK++ I++M+IQRVHY IKK A+++ LEF W+Q WD E+ + CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P I D NV RA +LLDQYRKK+ L+ +LVPLGDDFRY EW QY NY KL DYMN E +V+ +F LSDYFD++ K + +P LSGD F+YADR+DHYW+GY+TSRPF K LDRIL +HLR AEI+ SL+ + H ++ G V + SLL + +RR + LFQHHDA+ GT+K VV+D+ N+LL ++ + V AA ++ N +F Q + D+ ++ + + I ++++ RY+ LFN + Q R LV + V++ R ++++ Q + Q++ + A E + + SF + L + + S T S + + S+ V S+ + + SL L + TG +E + + ++ I F YG R S++ SGAYLF+PDG + EG L+ EVVA + F +++ V G+ ++DI +VDIR ++N E++M TD + D F+ D N FQ R+ F K+P+Q N YPM +YI+ DS ++ L + Q+ GV ++ G +EV LDR L QDDNRGL + L DN+ + +RLL E +S K VS L++ + + H++ + + L G LPCD+HL+N ++ + + L +HRL L+C
Sbjct: 131 MLDVYSLLNFDNVDGGVWKQGFEITYEPNEWDDEPLQVFVVPHSHNDPGWIKTFDKYYNDQTQHILNNMVTKMAEDPRRKFIWSEISYFAKWWESADVHKQEVMRKLILSGQLEMVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGVTPRSGWAVDPFGHSATMPYLLKRANISSMLIQRVHYSIKKHFAATRSLEFMWRQAWDIESSTDMFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAINDANVAERAGVLLDQYRKKSKLF-RSKVLLVPLGDDFRYDKALEWDQQYLNYQKLFDYMNSHPEMHVKAQFATLSDYFDAVYKANGVTSGARPPDYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYSLA-VAHARHAGVEGRYPVSDYSLLTD----ARRNIGLFQHHDAITGTAKEAVVIDYGNRLLRSLVGLKRVIINAAHFLIIKNKDIYRFYQTEPFLETDDRRATQDSLPQRTLIELESS-PRYLVLFNPVEQERLCLVT--VLVNSAR--VRVLTEDGQTLPVQLSAQWMSATEMSGEVYQASFMARLPALGLAVFHLYDSADSPMTLRSETLLRVPGRGQSIRGLDPLPVRSQTVDGQPFYIQSQSL-TLGFSGATGLLESIRRKDDPQEVRVQIQFLTYGTRPSKDKSGAYLFLPDGNAKPYSQREAPIVRVVEGPLFAEVVAHYQHFQQTVRIHNVPGVDGLSLDITTMVDIRDQNNKELAMRFVTD-IQSGDTFYTDLNGFQIQPRRYFQKLPLQANFYPMPSTAYIQ----DSQYRLTLHTAQALGV---TSLASGQ----LEVILDRRLMQDDNRGLGQGLKDNKRTANRFRLLLER----RSNSAKPVDSRPVSFPSLLSHMTSTILNHEVLALPVLPRKHGVPPMRTFAPLAG-TLPCDFHLLNLRSIQSPQDAHSPSPYMALLLHRLGLDC 1084
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2a2 (mannosidase, alpha, class 2A, member 2 [Source:ZFIN;Acc:ZDB-GENE-110331-1]) HSP 1 Score: 674.47 bits (1739), Expect = 0.000e+0 Identity = 391/983 (39.78%), Postives = 564/983 (57.38%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYK--YGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQI--IFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISD-TYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPV--HQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT--------NINEIPKLTIHRLKLNC 2941
M +Y L+F + DGGVWKQGF++ Y + L+VFVVPHSH DPGWIKT D+Y+ D TQ ILN+M+ + ++P KFI +E+ YF KWW + ++++ ++KLI + QLE+VTGGWVMTDEA AHY +MI+QL +GH WL+ NL TP +GWA+DPFG+S MPYLLK++ I++M+IQRVHY IKK A+++ LEF W+Q WD E+ + CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P I D NV RA +LLDQYRKK+ L+ +LVPLGDDFRY EW QY NY KL DYMN E +V+ +F LSDYFD++ K + +P LSGD F+YADR+DHYW+GY+TSRPF K LDRIL +HLR AEI+ SL+ + H ++ G V + SLL + +RR + LFQHHDA+ GT+K VV+D+ N+LL ++ + V AA ++ N +F Q + D+ ++ + + I ++++ RY+ LFN + Q R LV + V++ R ++++ Q + Q++ + A E + + SF + L + + S T S + + S+ V S+ + + SL L + TG +E + + ++ I F YG R S++ SGAYLF+PDG + EG L+ EVVA + F +++ V G+ ++DI +VDIR ++N E++M TD + D F+ D N FQ R+ F K+P+Q N YPM +YI+ DS ++ L + Q+ GV ++ G +EV LDR L QDDNRGL + L DN+ + +RLL E +S K VS L++ + + H++ + + L G LPCD+HL+N ++ + + L +HRL L+C
Sbjct: 131 MLDVYSLLNFDNVDGGVWKQGFEITYEPNEWDDEPLQVFVVPHSHNDPGWIKTFDKYYNDQTQHILNNMVTKMAEDPRRKFIWSEISYFAKWWESADVHKQEVMRKLILSGQLEMVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGVTPRSGWAVDPFGHSATMPYLLKRANISSMLIQRVHYSIKKHFAATRSLEFMWRQAWDIESSTDMFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAINDANVAERAGVLLDQYRKKSKLF-RSKVLLVPLGDDFRYDKALEWDQQYLNYQKLFDYMNSHPEMHVKAQFATLSDYFDAVYKANGVTSGARPPDYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYSLA-VAHARHAGVEGRYPVSDYSLLTD----ARRNIGLFQHHDAITGTAKEAVVIDYGNRLLRSLVGLKRVIINAAHFLIIKNKDIYRFYQTEPFLETDDRRATQDSLPQRTLIELESS-PRYLVLFNPVEQERLCLVT--VLVNSAR--VRVLTEDGQTLPVQLSAQWMSATEMSGEVYQASFMARLPALGLAVFHLYDSADSPMTLRSETLLRVPGRGQSIRGLDPLPVRSQTVDGQPFYIQSQSL-TLGFSGATGLLESIRRKDDPQEVRVQIQFLTYGTRPSKDKSGAYLFLPDGNAKPYSQREAPIVRVVEGPLFAEVVAHYQHFQQTVRIHNVPGVDGLSLDITTMVDIRDQNNKELAMRFVTD-IQSGDTFYTDLNGFQIQPRRYFQKLPLQANFYPMPSTAYIQ----DSQYRLTLHTAQALGV---TSLASGQ----LEVILDRRLMQDDNRGLGQGLKDNKRTANRFRLLLER----RSNSAKPVDSRPVSFPSLLSHMTSTILNHEVLALPVLPRKHGVPPMRTFAPLAG-TLPCDFHLLNLRSIQSPQDAHSPSPYMALLLHRLGLDC 1084
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2b1 (mannosidase, alpha, class 2B, member 1 [Source:ZFIN;Acc:ZDB-GENE-050327-52]) HSP 1 Score: 252.677 bits (644), Expect = 1.706e-69 Identity = 242/945 (25.61%), Postives = 411/945 (43.49%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYFKDD--------TQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSIC----CQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMN--KQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQ-LAEFNNNQHFVS----FKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGA-----RRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEG-ELYDEVVAENKLF----SHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRK-----TFD---KIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVD-----NEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKT---NFTNSVPSNLVGQKSLLTGY--GLPCDYHLI 2878
PH+H D GW+KTVD+YF D Q IL+S++D L K+P +FI+ E +F +WW ++N + V +L+ +LE + GGW M+DEAT HYS++I+Q+ G +L + P W IDPFG+++ + + G + R+ Y K R +K++E W+ SE S+ + F+ +P+ P C C IR +DP ++ D NV + L+ K+A Y N++++ +G DF+Y+ W Y+N KL+ Y+N + K + + + S Y L +P + D F YAD +WTGYFTSRP LK+ +R+ + L+ + L G T + D RR + + QHHDAV+GT K HV D+ +L + + + + + + + + V L S +F+ N ++N L + + V +P+ + + + + ++ P+ + E N+ F F++ PL + S+ I + + ++ KN SS ++N K+ +STTG + + +L ++ +L F Y A + S + SGAY+F P+ I ++ + LY+ V + F S +++L++ L + V + E+ + TD + S F+ DSN + + R+ T+D PI GN YP+ +YI+ D R++ +++ +S G +I+ GS +E+ L R L DD RG+ EPL + + +V++G LL T+S + DL P+ Q V +F + PS G K +G LP HL+
Sbjct: 50 PHTHDDVGWLKTVDQYFYGDRNNIQHAGVQYILDSVIDQLQKDPARRFIYVETAFFYRWWRQQNQNTRRIVTQLVNEGRLEFINGGWCMSDEATTHYSAVIDQMTLGLRFLNDTFGECGRPRVAWHIDPFGHAREHASIFAQMGYDGFFFGRLDYQDKDRRMKTKEMEMLWRA---SE---SLTPPIADLFTGVLPNGYNPPEGFCWDQSCDDAPIR---------DDP-DLEDYNVDEIVQKFLNASHKQADYYKT-NHIIMTMGSDFQYENANLW---YKNMDKLIKYVNALQAKGSKLNVLYSTPSCYLQELNLANF-TWPMKTDDFFPYADDAHDFWTGYFTSRPALKLYERLSNSRLQTCNQLEVL----------GGPTSTSGPFGEGDSDTMRRAMGVAQHHDAVSGTEKQHVANDYARRLATGWAHCEVLVSNSLAVLSGSEAPRVFCENLNISVCPLTESSHKFSMN--------------VYNPLGRTVRWPVRLPVNGSV----YNVTDANGKAVDSEVIPLSKSRKEVRQNRGFAKSELVFQVEAPPLGY---------------STYIISMVQDQPPVSRSKNAVPSS----------IQNKFLKVTFDSTTGLLSSLTNLETQQTIRLTQNFFWYNASAGNNKESHQPSGAYIFRPNSSDPFI----ISKTAEIQAVSLYNSVQEVTQRFSPWVSQVVRLYEDRRELELEWTV-GPVPVEDGLGKEVITRLDTD-IQSSGYFYTDSNGREVLERRKDYRPTWDLKQTEPIAGNYYPINSRAYIK----DDKRQLTVVTDRSQG---ASSIYNGS----LEIMLHRRLLYDDFRGVGEPLSEPGEFAHGLVARGRLLL------------------TLSPPEAAADLHRPLAQSMVLQPLLSFQDGAPS--PGTKLEFSGLQAALPPAVHLL 883
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Match: man2a1 (mannosidase, alpha, class 2A, member 1 [Source:ZFIN;Acc:ZDB-GENE-060526-31]) HSP 1 Score: 229.95 bits (585), Expect = 1.084e-66 Identity = 109/209 (52.15%), Postives = 149/209 (71.29%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSE 694
M +Y+ L F + DGGVWKQGF + Y + L+VFVVPHSH DPGW+KT D+Y++D TQ ILN+M+ L ++ K I +E+ YF KWW++I ++D V++L++N QLE+ TGGWVM DEA AHY +MI+QL +GH WL+ NL P TGWA+DPFG++ YLLK +G++NM+IQRVHY +KK +S K LEF W+Q W +
Sbjct: 129 MLDVYDLLRFDNPDGGVWKQGFDISYQENEWDNEPLQVFVVPHSHNDPGWLKTFDDYYRDQTQHILNNMVVKLHEDSRRKMIWSEISYFAKWWDSIDGQKQDAVRRLVENGQLEVATGGWVMPDEANAHYFAMIDQLVEGHQWLERNLGVKPKTGWAVDPFGHTATQAYLLKLAGLSNMLIQRVHYSVKKHFSSQKTLEFFWRQNWGEQ 337
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: man2a1 (mannosidase, alpha, class 2A, member 1 [Source:NCBI gene;Acc:100036612]) HSP 1 Score: 670.233 bits (1728), Expect = 0.000e+0 Identity = 410/1044 (39.27%), Postives = 589/1044 (56.42%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYK--YGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFN-NNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFED-WKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT---NINEIPK----LTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAV 3133
M +Y+ L F + DGGVWKQGF + Y + L+VF+VPHSH DPGW+KT D+YF+D TQ ILN+M+ L ++ N KF+ +E+ YF KWW+ I +K+ VK+LI+ +Q EIVTGGWVM DEAT HY S+++QL +GH WL+ NL P +GWAIDPFG+S M Y+LK SG++NM+IQRVHY IKK AS + LEF W+Q WD + I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P I + NV+ RA M+LDQYRKK+ LY +LVPLGDDFRY EW QY NY KL YMN E +V+ +FG +SDYF +L+K + FP LSGD F+YADR DHYW+GYFTSRPF K L+R++ +HLRAAEI+ S +L+ NK+ +V + LL E +RR L LFQHHDA+ GT+K VVVD+ +L +++ + V AA ++ + ++ F +D+++ + + I I T RY+ ++N Q R +V + I SG L K QI+ ++ + + VSF + L +++ S++ + I + ++N NF++ N ++ V ++N+ KL S++G +E ++ + + + F YG +R+ SGAYLF+PDGE + G ++ EVV K +H ++L+ V GL + +I N+VDIR E N EI M I +D + F+ D N +Q R+T K+PIQ NVYPMT +YI+ D ++ L S QS GV K+ +EVFLDR L QDDNRGL + + DN++ S +RLL E + + + D K ++ S+ L +PV M ++ +SV N L +PCD HL+N +T + IP L +HR +C G C + K + + +F+ +I+ + SL+ + +I ++ MDI T+ +
Sbjct: 46 MLDVYDILPFDNPDGGVWKQGFDISYDEHEWDNEPLQVFLVPHSHNDPGWLKTFDDYFRDQTQHILNNMVIKLQEDKNRKFMWSEISYFSKWWDGIDNQKKEAVKRLIELEQFEIVTGGWVMPDEATPHYFSLVDQLIEGHQWLEKNLGVKPKSGWAIDPFGHSPTMAYILKSSGLSNMLIQRVHYSIKKYFASKQTLEFFWRQNWDLGHSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVSCPWRVPPEVINEGNVQHRAWMILDQYRKKSKLY-RTKVLLVPLGDDFRYTDSLEWDQQYENYQKLFSYMNSHPELHVKAQFGTISDYFKALRKAGNVDDPNSQSFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRLERVMESHLRAAEILYSFALVQMNKFDKLQSFPSVEHYKLLTE----ARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMNLKRVIIDAAHVLVLKDKDTYAYNPSSPFFSMDDVQPSQDSLPQKTVIKI-TEIPRYLTVYNPTEQERYSVV---SVYVSSSKVKVISASGKAL-KAQISAVWNGDSAPLQDMYQVSFLAYLPALGLAVYKLVEAENSESIKADYTIFVQGKHKNINSDGNFRIKEVNIVVGD-VTIENTYLKLWF-SSSGLLEKIQSKEDGKTHGVKVDFIWYGTTNNRDKSGAYLFLPDGEAKPYINADPPVVRVTHGSIFSEVVVFFKHLTHTVRLYNVHGLEGQSPEITNVVDIRGEFNREIVMRITSD-INSKHRFYTDLNGYQIQPRRTLSKLPIQANVYPMTSMAYIQ----DDASRLTLHSAQSLGVASSKS-------GQLEVFLDRRLMQDDNRGLGQGVQDNKITSNLFRLLLEKRFGKDEKEDEKPVSYPSILSHITSMFLNHPVIPMAATSDSGSSVLLNAF----LPLTSSMPCDVHLLNLRTIQAKVGPIPSDEAALILHRKGFDCKFSNKDLGLLCSTTQGKVSVHR-LFNGFNIESLIPSSLTLMHSSSNSKNTTEIRISTMDIKTFRI 1060
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: man2a2 (mannosidase, alpha, class 2A, member 2 [Source:NCBI gene;Acc:448465]) HSP 1 Score: 665.226 bits (1715), Expect = 0.000e+0 Identity = 389/986 (39.45%), Postives = 561/986 (56.90%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKD-------KIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKY----KYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQII--FDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQ-LAEFNNNQHFVSFKLNIGPLAFERVRILATGISDT---YCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDL--IYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINE---IPK----LTIHRLKLNC 2941
M +Y L F + DGGVWKQGF + Y ++ L+VFVVPHSH DPGWIKT D+Y+ D TQ ILN+M+ L ++P KFI +E+ +F KWW+ I+ ++ V++L+ + QLE+ TGGWVM DEA HY +MI+Q+ +GH WLK NL+ TP +GWA+DPFG+S MPY+L++S + +M+IQRVHY IKK A+++ LEF W+Q WD ++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P ITD NV RA +LLDQY+KK+ LY VLVPLGDDFRY +EW Q+ NY KL DYMN E +V+ +FG LSDYFD+L K K FP +SGD FSYADR+DHYWTGY+TSRPF K +DR+L +HLR AEI+ SL++ + K KY LS + +LL + +RR L LFQHHDA+ GT+K VV+D+ +LL+++ + + AA ++ + +D + F D + E + I + T RYV +FN + Q R +V + + ++++ Q + Q++P++Q + + N + + VS L F + R L + SD C ++ L+ + ++ + + E + K L N ++ ++ + + K+N+ F YG R S++ SGAYLF+PDGE + EG Y EV + + +++L+ + G ++DI +++DIR N EI+M + TD + D FF D N FQ R+ F K+P+Q N YPM +YI+ D ++ L + Q+ GV K +EV LDR L QDDNRGL + L DN+ + +R+ E +S NK G VS L++ + ++ H V P+ Q T LPCD+H++N +T E +P L +HR +C
Sbjct: 131 MLDVYTQLPFDNVDGGVWKQGFDITYDPKEWDNEPLQVFVVPHSHNDPGWIKTFDKYYYDQTQHILNNMVVKLHEDPRRKFIWSEISFFSKWWDNINSQKRAAVRRLVASGQLEMTTGGWVMPDEANTHYFAMIDQMIEGHQWLKKNLDATPRSGWAVDPFGHSSTMPYILRRSNLTSMLIQRVHYSIKKHFAATQSLEFMWRQTWDPDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFRRLPGGRINCPWKVPPRAITDSNVAERANILLDQYKKKSKLY-RSKVVLVPLGDDFRYDKIQEWDAQFLNYQKLFDYMNSHPELHVQAQFGTLSDYFDALYKRMGVVPGIKPPDFPVVSGDFFSYADREDHYWTGYYTSRPFYKSMDRVLESHLRGAEILYSLAINHARKAGTESKYPLS---DYALLTD----ARRNLGLFQHHDAITGTAKEAVVIDYGVRLLHSLMNLKRIIINAAHYLVVADKEKYHYDHSVPFFSTDESRLTQESLPEKTVIKL-TASPRYVVVFNPVEQNRLCVVSLLVNT----YNVRVLTEDGQPVAAQLSPVWQSVTDMNPDVYQVS------DLFFAQ-RNLPSKYSDCSFKVCRLTYLQLFFLIYPIDIRVCVPILHECKSIIKTFCLFN-------------VQSIKRAGEEQEQKINMQFLIYGTRTSKDKSGAYLFLPDGEAKPYTPKDPPVVKVTEGPFYSEVTCQYQHVQQVMRLYNLPGTEGLSLDISSLIDIRDHVNKEIAMRLSTD-IQSEDIFFTDLNGFQIQPRRFFKKLPLQANFYPMPTMAYIQ----DEQNRLTLHTAQALGVSSLKN-------GELEVILDRRLMQDDNRGLGQGLKDNKRLCSRFRIQMEK----RSAGNKSQGNQPVSFPSLLSHMTSMHLNHDPLVMAVSNEKSPALKSFQPLSAT---LPCDFHILNLRTLQAEDDGLPSPDMALILHRKGFDC 1064
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: man2a2 (mannosidase, alpha, class 2A, member 2 [Source:NCBI gene;Acc:448465]) HSP 1 Score: 661.374 bits (1705), Expect = 0.000e+0 Identity = 389/983 (39.57%), Postives = 561/983 (57.07%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKD-------KIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKY----KYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQII--FDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQ-LAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDL--IYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINE---IPK----LTIHRLKLNC 2941
M +Y L F + DGGVWKQGF + Y ++ L+VFVVPHSH DPGWIKT D+Y+ D TQ ILN+M+ L ++P KFI +E+ +F KWW+ I+ ++ V++L+ + QLE+ TGGWVM DEA HY +MI+Q+ +GH WLK NL+ TP +GWA+DPFG+S MPY+L++S + +M+IQRVHY IKK A+++ LEF W+Q WD ++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P ITD NV RA +LLDQY+KK+ LY VLVPLGDDFRY +EW Q+ NY KL DYMN E +V+ +FG LSDYFD+L K K FP +SGD FSYADR+DHYWTGY+TSRPF K +DR+L +HLR AEI+ SL++ + K KY LS + +LL + +RR L LFQHHDA+ GT+K VV+D+ +LL+++ + + AA ++ + +D + F D + E + I + T RYV +FN + Q R +V + + ++++ Q + Q++P++Q + + N + + VS L F + R L + SD+ S + L +++ S E ++ + K + ++ S ++ + + K+N+ F YG R S++ SGAYLF+PDGE + EG Y EV + + +++L+ + G ++DI +++DIR N EI+M + TD + D FF D N FQ R+ F K+P+Q N YPM +YI+ D ++ L + Q+ GV K +EV LDR L QDDNRGL + L DN+ + +R+ E +S NK G VS L++ + ++ H V P+ Q T LPCD+H++N +T E +P L +HR +C
Sbjct: 131 MLDVYTQLPFDNVDGGVWKQGFDITYDPKEWDNEPLQVFVVPHSHNDPGWIKTFDKYYYDQTQHILNNMVVKLHEDPRRKFIWSEISFFSKWWDNINSQKRAAVRRLVASGQLEMTTGGWVMPDEANTHYFAMIDQMIEGHQWLKKNLDATPRSGWAVDPFGHSSTMPYILRRSNLTSMLIQRVHYSIKKHFAATQSLEFMWRQTWDPDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFRRLPGGRINCPWKVPPRAITDSNVAERANILLDQYKKKSKLY-RSKVVLVPLGDDFRYDKIQEWDAQFLNYQKLFDYMNSHPELHVQAQFGTLSDYFDALYKRMGVVPGIKPPDFPVVSGDFFSYADREDHYWTGYYTSRPFYKSMDRVLESHLRGAEILYSLAINHARKAGTESKYPLS---DYALLTD----ARRNLGLFQHHDAITGTAKEAVVIDYGVRLLHSLMNLKRIIINAAHYLVVADKEKYHYDHSVPFFSTDESRLTQESLPEKTVIKL-TASPRYVVVFNPVEQNRLCVVSLLVNT----YNVRVLTEDGQPVAAQLSPVWQSVTDMNPDVYQVS------DLFFAQ-RNLPSKYSDSLHSPPRLLLLYGRST---------SGEPGVI---IPHKATFCLFNVQS-------IKRAGEEQEQKINMQFLIYGTRTSKDKSGAYLFLPDGEAKPYTPKDPPVVKVTEGPFYSEVTCQYQHVQQVMRLYNLPGTEGLSLDISSLIDIRDHVNKEIAMRLSTD-IQSEDIFFTDLNGFQIQPRRFFKKLPLQANFYPMPTMAYIQ----DEQNRLTLHTAQALGVSSLKN-------GELEVILDRRLMQDDNRGLGQGLKDNKRLCSRFRIQMEK----RSAGNKSQGNQPVSFPSLLSHMTSMHLNHDPLVMAVSNEKSPALKSFQPLSAT---LPCDFHILNLRTLQAEDDGLPSPDMALILHRKGFDC 1055
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: man2a2 (mannosidase, alpha, class 2A, member 2 [Source:NCBI gene;Acc:448465]) HSP 1 Score: 659.062 bits (1699), Expect = 0.000e+0 Identity = 378/982 (38.49%), Postives = 552/982 (56.21%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKD-------KIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKY----KYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQII--FDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDL--IYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINE---IPK----LTIHRLKLNC 2941
M +Y L F + DGGVWKQGF + Y ++ L+VFVVPHSH DPGWIKT D+Y+ D TQ ILN+M+ L ++P KFI +E+ +F KWW+ I+ ++ V++L+ + QLE+ TGGWVM DEA HY +MI+Q+ +GH WLK NL+ TP +GWA+DPFG+S MPY+L++S + +M+IQRVHY IKK A+++ LEF W+Q WD ++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P ITD NV RA +LLDQY+KK+ LY VLVPLGDDFRY +EW Q+ NY KL DYMN E +V+ +FG LSDYFD+L K K FP +SGD FSYADR+DHYWTGY+TSRPF K +DR+L +HLR AEI+ SL++ + K KY LS + +LL + +RR L LFQHHDA+ GT+K VV+D+ +LL+++ + + AA ++ + +D + F D + E + I + T RYV +FN + Q R +V + + ++++ Q + Q++P++Q ++D ++ +Y + + ++N +L+K ++ + + ++ ++ + + K+N+ F YG R S++ SGAYLF+PDGE + EG Y EV + + +++L+ + G ++DI +++DIR N EI+M + TD + D FF D N FQ R+ F K+P+Q N YPM +YI+ D ++ L + Q+ GV K +EV LDR L QDDNRGL + L DN+ + +R+ E + +G+ G F VS L++ + ++ H V P+ Q T LPCD+H++N +T E +P L +HR +C
Sbjct: 143 MLDVYTQLPFDNVDGGVWKQGFDITYDPKEWDNEPLQVFVVPHSHNDPGWIKTFDKYYYDQTQHILNNMVVKLHEDPRRKFIWSEISFFSKWWDNINSQKRAAVRRLVASGQLEMTTGGWVMPDEANTHYFAMIDQMIEGHQWLKKNLDATPRSGWAVDPFGHSSTMPYILRRSNLTSMLIQRVHYSIKKHFAATQSLEFMWRQTWDPDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFRRLPGGRINCPWKVPPRAITDSNVAERANILLDQYKKKSKLY-RSKVVLVPLGDDFRYDKIQEWDAQFLNYQKLFDYMNSHPELHVQAQFGTLSDYFDALYKRMGVVPGIKPPDFPVVSGDFFSYADREDHYWTGYYTSRPFYKSMDRVLESHLRGAEILYSLAINHARKAGTESKYPLS---DYALLTD----ARRNLGLFQHHDAITGTAKEAVVIDYGVRLLHSLMNLKRIIINAAHYLVVADKEKYHYDHSVPFFSTDESRLTQESLPEKTVIKL-TASPRYVVVFNPVEQNRLCVVSLLVNT----YNVRVLTEDGQPVAAQLSPVWQ------------------------------SVTD-----MNPDVYQVSDLFFAQRNLPSKYSELMLSKAKLIGYHFSVIWPSFCLFNVQSIKRAGEEQEQKINMQFLIYGTRTSKDKSGAYLFLPDGEAKPYTPKDPPVVKVTEGPFYSEVTCQYQHVQQVMRLYNLPGTEGLSLDISSLIDIRDHVNKEIAMRLSTD-IQSEDIFFTDLNGFQIQPRRFFKKLPLQANFYPMPTMAYIQ----DEQNRLTLHTAQALGVSSLKN-------GELEVILDRRLMQDDNRGLGQGLKDNKRLCSRFRIQME---KRSAGNKVSVGPFPVSFPSLLSHMTSMHLNHDPLVMAVSNEKSPALKSFQPLSAT---LPCDFHILNLRTLQAEDDGLPSPDMALILHRKGFDC 1058
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Match: man2a1 (mannosidase, alpha, class 2A, member 1 [Source:NCBI gene;Acc:100036612]) HSP 1 Score: 654.825 bits (1688), Expect = 0.000e+0 Identity = 409/1042 (39.25%), Postives = 581/1042 (55.76%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYK--YGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFN-NNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFED-WKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT---NINEIPK----LTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAV 3133
M +Y+ L F + DGGVWKQGF + Y + L+VF+VPHSH DPGW+KT D+YF+D TQ ILN+M+ L ++ N KF+ +E+ YF KWW+ I +K+ VK+LI+ +Q EIVTGGWVM DEAT HY S+++QL +GH WL+ NL P +GWAIDPFG+S M Y+LK SG++NM+IQRVHY IKK AS + LEF W+Q WD + I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P I + NV+ RA M+LDQYRKK+ LY +LVPLGDDFRY EW QY NY KL YMN E +V+ +FG +SDYF +L+K + FP LSGD F+YADR DHYW+GYFTSRPF K L+R++ +HLRAAEI+ S +L+ NK+ +V + LL E +RR L LFQHHDA+ GT+K VVVD+ +L +++ + V AA ++ + + N S KN + RY+ ++N Q R +V + I SG L K QI+ ++ + + VSF + L +++ S++ + I + ++N NF++ N ++ V ++N+ KL S++G +E+ + + + F YG +R+ SGAYLF+PDGE + G ++ EVV K +H ++L+ V GL + +I N+VDIR E N EI M I +D + F+ D N +Q R+T K+PIQ NVYPMT +YI+ D ++ L S QS GV K+ +EVFLDR L QDDNRGL + + DN++ S +RLL E + + + D K ++ S+ L +PV M ++ +SV N L +PCD HL+N +T + IP L +HR +C G C + K + + +F+ +I+ + SL+ + +I ++ MDI T+ +
Sbjct: 133 MLDVYDILPFDNPDGGVWKQGFDISYDEHEWDNEPLQVFLVPHSHNDPGWLKTFDDYFRDQTQHILNNMVIKLQEDKNRKFMWSEISYFSKWWDGIDNQKKEAVKRLIELEQFEIVTGGWVMPDEATPHYFSLVDQLIEGHQWLEKNLGVKPKSGWAIDPFGHSPTMAYILKSSGLSNMLIQRVHYSIKKYFASKQTLEFFWRQNWDLGHSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVSCPWRVPPEVINEGNVQHRAWMILDQYRKKSKLY-RTKVLLVPLGDDFRYTDSLEWDQQYENYQKLFSYMNSHPELHVKAQFGTISDYFKALRKAGNVDDPNSQSFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRLERVMESHLRAAEILYSFALVQMNKFDKLQSFPSVEHYKLLTE----ARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMNLKRVIIDAAHVLVLKDKDTYAY--------NPSSPFFSMVKNILPSVYY---RYLTVYNPTEQERYSVV---SVYVSSSKVKVISASGKAL-KAQISAVWNGDSAPLQDMYQVSFLAYLPALGLAVYKLVEAENSESIKADYTIFVQGKHKNINSDGNFRIKEVNIVVGD-VTIENTYLKLWF-SSSGLLEVRLCKEDGKTHGVKVDFIWYGTTNNRDKSGAYLFLPDGEAKPYINADPPVVRVTHGSIFSEVVVFFKHLTHTVRLYNVHGLEGQSPEITNVVDIRGEFNREIVMRITSD-INSKHRFYTDLNGYQIQPRRTLSKLPIQANVYPMTSMAYIQ----DDASRLTLHSAQSLGVASSKS-------GQLEVFLDRRLMQDDNRGLGQGVQDNKITSNLFRLLLEKRFGKDEKEDEKPVSYPSILSHITSMFLNHPVIPMAATSDSGSSVLLNAF----LPLTSSMPCDVHLLNLRTIQAKVGPIPSDEAALILHRKGFDCKFSNKDLGLLCSTTQGKVSVHR-LFNGFNIESLIPSSLTLMHSSSNSKNTTEIRISTMDIKTFRI 1135
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2a2 (mannosidase 2, alpha 2 [Source:MGI Symbol;Acc:MGI:2150656]) HSP 1 Score: 670.233 bits (1728), Expect = 0.000e+0 Identity = 400/1053 (37.99%), Postives = 597/1053 (56.70%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQS---LLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQ--IIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISDTYC--SSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGY-----GLPCDYHLINFKTNINE--IP----KLTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M + E L F + +GGVW+QGF + Y+ D L+VFVVPHSH DPGWIKT D+Y+ + TQ ILNSM+ L ++P +F+ AEV +F KWW+ IS ++ V++L+ N QLEI TGGWVM DEA +HY ++++QL +GH WL+ NL TP +GWA+DPFG+S MPYLL+++ + +M+IQRVHY IKK A++ LEF W+Q WDS++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ NV RA +LLDQYRKK+ L+ N +LVPLGDDFRY +EW Q+ NY +L D++N + E++V+ +FG LS+YFD+L K + FP LSGD FSYADR+DHYWTGY+TSRPF K LDR+L HLR AEI+ SL+L + + GL+ + S LL E +RRTL LFQHHDA+ GT+K VVVD+ +LL ++ + V AA ++ + FD +D+ + + + I + ++ R+V +FN L Q R L + + V++ R ++++ Q + QI+ + A + + + VS + + L V L + Y SSV ++L +K S++ + F V +S + + + N ++ + TG ++ + + + + ++ + F YG R S++ SGAYLF+PD E + EG + EV + F +++L+ + G+ ++D+ VDIR N E+++ I TD + FF D N FQ R+ K+P+Q N YPM +YI+ DS R++ L + Q+ GV ++ G +EV LDR L QDDNRGL + L DN++ +RLL E + ++E E + S L++ L M++ T + G L + LPCD+HL+N + E +P L +HR +C + G +C + K L S+F + + ++ SL+ + DI + M+I T+ +
Sbjct: 131 MLTVSEDLPFDNVEGGVWRQGFDISYSPNDWDTEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYRKKSRLF-RSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLNSKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEILYSLALAHAR--RSGLAGQYPLSDFALLTE----ARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDQETYSFDPGTPFLQMDDSRVSHDALPERTVIRLDSS-PRFVVVFNPLEQER--LSVVSLLVNSPR--VRVLSEEGQPLSVQISVHWSSATDMVPDVYQVSVPVRLPGLGLG-VLQLQPDLDGPYTLQSSVRVYLNGVKLSVSRQSAFPVRVVDSGASDFAI-SNRYMQVWFSGLTGLLKSIRRVDEEQEQQMELEFLVYGTRTSKDKSGAYLFLPDSEAKPYVPKKPPVLRVTEGPFFSEVAVYYEHFHQVIRLYNLPGVEGLSLDMSFQVDIRDYVNKELALRIHTD-IDSQGTFFTDLNGFQIQPRQYLKKLPLQANFYPMPVMAYIQ----DSQRRLTLHTAQALGV---SSLGNGQ----LEVILDRRLMQDDNRGLGQGLKDNKITCNRFRLLLERRTTMSPEVHQE-QERSTSYPSLLSHLT----SMYLSTPPLVLPVAKRQGTSPALRSFHPLASPLPCDFHLLNLRMLPAEDTLPATDSALILHRKGFDCGLEAKNLGFNCTTSQGKLAL-GSLFHGLDVTFLQPTSLTLLYPLASPSNSTDISLEPMEISTFRLRL 1151
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2a1 (mannosidase 2, alpha 1 [Source:MGI Symbol;Acc:MGI:104669]) HSP 1 Score: 668.692 bits (1724), Expect = 0.000e+0 Identity = 393/1052 (37.36%), Postives = 600/1052 (57.03%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSL-------KKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAI-KMSQFVFTYAAQRILQN-NIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQ-LAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSL-LNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSY-QLMNDLIYP-VHQMFVKTNFTNSVPS---NLVGQKSLLTGYGLPCDYHLINFKTNINEIPK-------LTIHRLKLNCYAGYISEG---SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y+ + F + DGGVWKQGF ++Y ++ L+VFVVPHSH DPGW+KT ++YF+D TQ I N+M+ L ++ + KF+ +E+ Y KWW+ I +K+ VK L++N QLEIVTGGWVM DEAT HY ++I+QL +GH WL+ NL P +GWAIDPFG+S M YLLK++G ++M+IQRVHY IKK + K LEF W+Q WD + I CHMMPF+SYD+PHTCGPDP ICCQFDF R+ R CPWG P I+ NV+ RA+MLLDQYRKK+ L+ +L PLGDDFR+ EW +Q RNY +L YMN Q V+I+FG LSDYFD+L KK +FP+LSGD F+YADR DHYW+GYFTSRPF K +DRI+ + +RAAEI+ L+L KYK F S + + +RR L LFQHHDA+ GT+K VVVD+ +L ++ + + + A IL++ + S + ++D +S + + I + RY+ ++N Q R +V I + T +K++ + ++ Q++ ++ + + + VSF +I PL + +IL ++ SS H+ Y + N+ +N +N + + ++N + + +G +E V +++L + F YG R+ SGAYLF+PDG+G + G +Y +V + +H ++L+ + G+ ++++ NIV+IR N EI M I + + + ++ D N +Q R+T K+P+Q NVYPM +YI+ D+ ++ LLS QS G ++ G IEVF+DR L QDDNRGL + + DN++ + +R+L E +S N E + + SY L++ + ++ F+ + +PS L+ + LL LPCD HL+N +T +++ K L +HR +C + S G C + K ++K +F+ +++ + SLS D ++ ++ M+I T+ +
Sbjct: 130 MLDVYDLIPFDNPDGGVWKQGFDIKYEADEWDHEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSSRKFMWSEISYLAKWWDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLGVKPRSGWAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLGSATDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSKLFRT-KVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQPHLKVKIQFGTLSDYFDALEKAVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALKQAQKYKI---NKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPQKIIIQLSAQEPRYLVVYNPFEQERHSVVSIRVNSAT----VKVLSDSGKPVEVQVSAVWNDMRTISQAAYEVSFLAHIPPLGLKVFKIL-----ESQSSSSHLADYVLYNNDGLAENGIFHVKNMVDAGDAITIENPFLAIWFD-RSGLMEKVRRKEDSRQHELKVQFLWYGTTNKRDKSGAYLFLPDGQGQPYVSLRPPFVRVTRGRIYSDVTCFLEHVTHKVRLYNIQGIEGQSMEVSNIVNIRNVHNREIVMRISSK-INNQNRYYTDLNGYQIQPRRTMSKLPLQANVYPMCTMAYIQ----DAEHRLTLLSAQSLG---ASSMASGQ----IEVFMDRRLMQDDNRGLGQGVHDNKITANLFRILLEK----RSAVNMEEEKKSPVSYPSLLSHMTSSFLNHPFLPMVLSGQLPSPAFELLSEFPLLQS-SLPCDIHLVNLRTIQSKMGKGYSDEAALILHRKGFDCQ--FSSRGIGLPCSTTQGKMSVLK-LFNKFAVESLVPSSLSLMHSPPDAQNMSEVSLSPMEISTFRIRL 1147
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2a2 (mannosidase 2, alpha 2 [Source:MGI Symbol;Acc:MGI:2150656]) HSP 1 Score: 468.774 bits (1205), Expect = 4.710e-153 Identity = 224/419 (53.46%), Postives = 293/419 (69.93%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEI-VLSLSLIYHNKYKYGLS 1294
M + E L F + +GGVW+QGF + Y+ D L+VFVVPHSH DPGWIKT D+Y+ + TQ ILNSM+ L ++P +F+ AEV +F KWW+ IS ++ V++L+ N QLEI TGGWVM DEA +HY ++++QL +GH WL+ NL TP +GWA+DPFG+S MPYLL+++ + +M+IQRVHY IKK A++ LEF W+Q WDS++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ NV RA +LLDQYRKK+ L+ N +LVPLGDDFRY +EW Q+ NY +L D++N + E++V+ +FG LS+YFD+L K + FP LSGD FSYADR+DHYWTGY+TSRPF K LDR+L HLR+A L +H + G S
Sbjct: 131 MLTVSEDLPFDNVEGGVWRQGFDISYSPNDWDTEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYRKKSRLF-RSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLNSKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRSAYTGPLPAPRCHHGNRQGGSS 548
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2b1 (mannosidase 2, alpha B1 [Source:MGI Symbol;Acc:MGI:107286]) HSP 1 Score: 222.631 bits (566), Expect = 2.708e-59 Identity = 248/1039 (23.87%), Postives = 447/1039 (43.02%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYF--------KDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNL--NYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALL---YDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWN--VEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIK------CQINPIFQLAEFNNN-QHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKY----GARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAE-NKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRK-------TFDKI-PIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSK--GYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDL--IYPVH-QMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEIPKLTIHRLKLNCYAGYISEGSCKFLRKKSPL-MKSMFDDVSIKYVNKFSLSGNQVIG-------------------DKVKPEDICMNLMDIDTY 3127
PH+H D GW+KTVD+Y+ Q IL+S++ L+++P +FI+ E+ +F +WW + +D V+ L++ +LE V GGWVM DEA HY ++++Q+ G +L++ + P W IDPFG+S+ L + G + + R+ Y + +L K+L R ++ W + + S+ F+ +P+ P +C +D + C + PV + + A+ L++ + K A + N+ ++ +G DF Y+ W ++N KL+ +N Q+ V + + + Y L K + + D F YAD +WTGYF+SRP LK +R+ N L+ + +L N YG + + L E +++ QHHDAV+GT++ +VV D+ QL + + + A R+ S ++ + + SERF V L+N L + +V +P+ GN ++K N + + ++ Q + F ++ L F + S ++ +N+ + K+ V +V++N + +S TG + +E+L ++ F Y G S + SGAY+F P+ G I I + L EV + S +++L+K L + I +R + E+ T +FF DSN + ++R+ T ++ P+ GN YP+ YI D ++ +L+ +S G G ++ GS +E+ + R L DD+RG+ EPL++ + K G L+ + ++ E V + Q++ L P H + KT F+ + Q+ LP HL+ T PK+ + RL+ + + E S + L L ++++F +I Y+ + +L+ NQ + K+ P + + M+I T+
Sbjct: 69 PHTHDDVGWLKTVDQYYYGILSDVQHASVQYILDSVVSSLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDY--QDKLNRKKKL--RMEELWRASD--SLEPPAADLFTGVLPNNYNPPKYLC--WDVL------C--TDPPVVDNPRSPEFNAKTLVNYFLKLASSQKGFYRTNHTVMTMGSDFHYENANMW---FKNMDKLIRLVNAQQVNGSLVHVLYSTPTCYLWELNKANLT-WTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEANVGPYGSG---DSAPLQE-------AMAVLQHHDAVSGTARQNVVNDYARQLAAGWGPCEVLVSNALARLSHYKQNFSFCRELNISICPVSQTSERFQ--------------VTLYNPLGRKVDQMVRLPVY------------EGNFIVKDPHDKNISSNVVMVPSYYSETYQWELLFPASVPALGFSTYSV-------AKMSDLNHQAHNLLSRPRKHKSHHV----------LVIENKYMRATFDSGTGLLMKIENLEQNLSLPVSQGFFWYNASVGDEESSQASGAYIFRPN-VGKPIPVSRWAQISLVKTALVQEVHQNFSAWCSQVIRLYKGQRHLELEWTVGPI-PVRDDWGKEVISRFDTPMKT-KGQFFTDSNGREILKRRDDYRPTWTLNQTEPVAGNYYPVNTRIYIT----DGQMQLTVLTDRSQG---GSSLQDGS----LELMVHRRLLVDDDRGVSEPLLETDTGDKVRGRHLVLLSSVSDAAARHRLLAEQEVLAPQVVLSLGGSSPYHSRATPKTQFSG------LRQE-------LPPQVHLL---TLARWGPKMLLLRLE---HQFALKEDSDRNLSSPVTLNVQNLFQTFTINYLQETTLAANQPLSRASRLKWMTNTGPTSYPEPSKLDPTSVTLKPMEIRTF 1001
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Match: Man2b2 (mannosidase 2, alpha B2 [Source:MGI Symbol;Acc:MGI:1195262]) HSP 1 Score: 176.407 bits (446), Expect = 1.609e-44 Identity = 117/410 (28.54%), Postives = 193/410 (47.07%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTI-SKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDP---VEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQ-KEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYG-LSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHV 1402
PHSH+D GW+ TV E + + +++ L++ +FI E +F WW+ + S+ QK QV++L+ +LE V GG VM DEA H I QL +GH +L P W +DPFG S P L +G N +I R+ Y +K + ++ L+F W + I H+M +SY P ++ + + P G P +T N+ + AE L+ +++A + +VL P G D ++ S+Q+ N L+DY+N++ ++ + +++ L+DYF +L + D Y+ WTG++TSR LK L R L A E + + +Y + S + + +++ R +S QHHDA+ GT V
Sbjct: 33 PHSHMDVGWVFTVQESMRAYAANVYTTVVAELVRGGQRRFIAVEQEFFRLWWDGVASEQQKQQVRQLLHEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQFSWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQMLQFVWHGSPSLSGQQEIFTHVMDHYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTGANIHLYAEALVANVKQRAAWFRT-PHVLWPWGCDKQFFNA---SVQFDNMDPLLDYINQRTAQFGISVQYATLNDYFQALHATNMTWGIRDHQDFLPYSSEPLQAWTGFYTSRSTLKGLARQASALLYAGESMFT-------RYMWPDPSGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKV 431
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|Q16706|MA2A1_HUMAN (Alpha-mannosidase 2 OS=Homo sapiens OX=9606 GN=MAN2A1 PE=1 SV=2) HSP 1 Score: 691.034 bits (1782), Expect = 0.000e+0 Identity = 407/1061 (38.36%), Postives = 605/1061 (57.02%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRII--YFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSL------KKDKIK-MFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYS--------------ERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNF--IEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPV--HQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEI-------PKLTIHRLKLNCYAGYISEGSCKFLRKKSP--LMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y + F + DGGVWKQGF + Y + L+VFVVPHSH DPGW+KT ++YF+D TQ I N+M+ L ++ KFI +E+ Y KWW+ I +KD VK LI+N QLEIVTGGWVM DEAT HY ++I+QL +GH WL+NN+ P +GWAIDPFG+S M YLL ++G+++M+IQRVHY +KK A K LEF W+Q WD + I CHMMPF+SYD+PHTCGPDP ICCQFDF R+ F CPWG P I NV+ RA MLLDQYRKK+ L+ +L PLGDDFRY EW +Q++NY +L DYMN Q ++ V+I+FG LSD+FD+L ++DK + MFP LSGD F+YADR DHYW+GYFTSRPF K +DRI+ +HLRAAEI+ +L +KYK F S L+ + +RR L LFQHHDA+ GT+K VVVD+ +L +++ +L+ IGNS F I+ D SYS + + N I + RY+ ++N L Q R LV + + T +++ + + ++ Q++ ++ A + + +SF+ +I PL + +IL + S+++ + ++ +++S F +++E + L+NS L + TG ++ + +++N+ F YG R+ SGAYLF+PDG + + + G +Y EV +H ++L+ + G+ ++++ NIVDIRK N EI+M I +D + + F+ D N +Q R T K+P+Q NVYPMT +YI+ D+ ++ LLS QS GV S++N IEV +DR L QDDNRGL + + DN++ + +R+L E +S N E + +VS L++ + + H + N +S L G+ S L LPCD HL+N +T +++ L +HR +C + S+G+ F L++ + + ++ + SLS +I ++ M+I T+ +
Sbjct: 131 MLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRT-KVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKI---NKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLM------------VLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAE-PRYLVVYNPLEQDRISLVSVYVSSPT----VQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEG-----ITLENSFVLLRFDQ-TGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSD-IKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQ----DAKHRLTLLSAQSLGV---------SSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEK----RSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQS-SLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCR--FSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQL 1143
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|P28494|MA2A1_RAT (Alpha-mannosidase 2 OS=Rattus norvegicus OX=10116 GN=Man2a1 PE=1 SV=2) HSP 1 Score: 676.011 bits (1743), Expect = 0.000e+0 Identity = 397/1052 (37.74%), Postives = 606/1052 (57.60%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSL-------KKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAI-KMSQFVFTYAAQRILQN-NIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQ-LAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSL-LNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNT--IVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSY-QLMNDLIYP-VHQMFVKTNFTNSVPS---NLVGQKSLLTGYGLPCDYHLINFKTNINEIPK-------LTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y+ + F + DGGVWKQGF ++Y ++ + L+VFVVPHSH DPGW+KT ++YF+D TQ I N+M+ L ++ + KFI +E+ Y KWW+ I +K+ VK L++N QLEIVTGGWVM DEAT HY ++I+QL +GH WL+ NL P +GWAIDPFG+S M YLLK++G ++M+IQRVHY +KK + K LEF W+Q WD + I CHMMPF+SYD+PHTCGPDP ICCQFDF R+ R CPWG P I+ NV+ RA+MLLDQYRKK+ L+ +L PLGDDFR+ EW +QYRNY +L YMN Q V+I+FG LSDYFD+L KK +FP+LSGD F+YADR DHYW+GYFTSRPF K +DRI+ + LR AEI+ L+L KYK F S + + +RR L LFQHHDA+ GT+K VVVD+ +L ++ + + + A IL++ + S + ++D +S + K N I + RY+ ++N Q R +V + + T +K++ + ++ Q++ +++ + + + V+F ++ PL + +IL ++ SS H+ Y + N+ ++ +N + + ++NS L + +G +E V + +L + F YG R+ SGAYLF+PDG+G + SL T + G +Y +V + +H ++L+ + G+ ++++ NIVDIR N EI M I + + + ++ D N +Q R+T K+P+Q NVYPM+ +YI+ D+ ++ LLS QS G ++ G IEVF+DR L QDDNRGL + + DN++ + +R+L E ++G N E + + SY L++ + ++ F+ + +PS L+ + LL LPCD HL+N +T +++ K L +HR +C + G C + K + K +F++ +++ SLS D ++ ++ M+I T +
Sbjct: 130 MLDVYDLIPFDNPDGGVWKQGFDIKYEADEWDREPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSSRKFIWSEISYLAKWWDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEKNLGVKPRSGWAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNWDLGSTTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSKLFRT-KVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQPHLKVKIQFGTLSDYFDALEKSVAAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRLRTAEILYHLALKQAQKYKI---NKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPKKNIIQLSAQEPRYLVVYNPFEQERHSVVSVRVNSAT----VKVLSDLGKAVEVQVSAVWKDMRTTSQAAYEVAFLAHLPPLGLKVYKIL-----ESQSSSSHLADYFLYNNDGQAESGIFHMKNMVDSGDAITIENSFLTLGFDR-SGLMEKVRRKEDNKQQELKVQFLWYGTTNKRDKSGAYLFLPDGQGQ--PYVSLRTPFVRVTRGRIYSDVTCFLEHVTHKVRLYHIQGIEGQSMEVSNIVDIRSVHNREIVMRISSK-INNQNRYYTDLNGYQIQPRRTMAKLPLQANVYPMSTMAYIQ----DAAHRLTLLSAQSLG---ASSMASGQ----IEVFMDRRLMQDDNRGLGQGVHDNKITANLFRILLEK----RNGMNMEEDKKSPVSYPSLLSHMTSAFLNHPFLPMVLSGQLPSPAIELLSEFRLLQS-SLPCDIHLVNLRTIQSKVGKGYSDEAALILHRKVFDCQLSSRAMGLPCSTTQGKMSIPK-LFNNFAVESFIPSSLSLMHSPPDAQNTSEVSLSPMEISTSRIRL 1147
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|Q8BRK9|MA2A2_MOUSE (Alpha-mannosidase 2x OS=Mus musculus OX=10090 GN=Man2a2 PE=1 SV=2) HSP 1 Score: 670.233 bits (1728), Expect = 0.000e+0 Identity = 400/1053 (37.99%), Postives = 597/1053 (56.70%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQS---LLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQ--IIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISDTYC--SSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGY-----GLPCDYHLINFKTNINE--IP----KLTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M + E L F + +GGVW+QGF + Y+ D L+VFVVPHSH DPGWIKT D+Y+ + TQ ILNSM+ L ++P +F+ AEV +F KWW+ IS ++ V++L+ N QLEI TGGWVM DEA +HY ++++QL +GH WL+ NL TP +GWA+DPFG+S MPYLL+++ + +M+IQRVHY IKK A++ LEF W+Q WDS++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ NV RA +LLDQYRKK+ L+ N +LVPLGDDFRY +EW Q+ NY +L D++N + E++V+ +FG LS+YFD+L K + FP LSGD FSYADR+DHYWTGY+TSRPF K LDR+L HLR AEI+ SL+L + + GL+ + S LL E +RRTL LFQHHDA+ GT+K VVVD+ +LL ++ + V AA ++ + FD +D+ + + + I + ++ R+V +FN L Q R L + + V++ R ++++ Q + QI+ + A + + + VS + + L V L + Y SSV ++L +K S++ + F V +S + + + N ++ + TG ++ + + + + ++ + F YG R S++ SGAYLF+PD E + EG + EV + F +++L+ + G+ ++D+ VDIR N E+++ I TD + FF D N FQ R+ K+P+Q N YPM +YI+ DS R++ L + Q+ GV ++ G +EV LDR L QDDNRGL + L DN++ +RLL E + ++E E + S L++ L M++ T + G L + LPCD+HL+N + E +P L +HR +C + G +C + K L S+F + + ++ SL+ + DI + M+I T+ +
Sbjct: 131 MLTVSEDLPFDNVEGGVWRQGFDISYSPNDWDTEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYRKKSRLF-RSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLNSKPEFHVQAQFGTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEILYSLALAHAR--RSGLAGQYPLSDFALLTE----ARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDQETYSFDPGTPFLQMDDSRVSHDALPERTVIRLDSS-PRFVVVFNPLEQER--LSVVSLLVNSPR--VRVLSEEGQPLSVQISVHWSSATDMVPDVYQVSVPVRLPGLGLG-VLQLQPDLDGPYTLQSSVRVYLNGVKLSVSRQSAFPVRVVDSGASDFAI-SNRYMQVWFSGLTGLLKSIRRVDEEQEQQMELEFLVYGTRTSKDKSGAYLFLPDSEAKPYVPKKPPVLRVTEGPFFSEVAVYYEHFHQVIRLYNLPGVEGLSLDMSFQVDIRDYVNKELALRIHTD-IDSQGTFFTDLNGFQIQPRQYLKKLPLQANFYPMPVMAYIQ----DSQRRLTLHTAQALGV---SSLGNGQ----LEVILDRRLMQDDNRGLGQGLKDNKITCNRFRLLLERRTTMSPEVHQE-QERSTSYPSLLSHLT----SMYLSTPPLVLPVAKRQGTSPALRSFHPLASPLPCDFHLLNLRMLPAEDTLPATDSALILHRKGFDCGLEAKNLGFNCTTSQGKLAL-GSLFHGLDVTFLQPTSLTLLYPLASPSNSTDISLEPMEISTFRLRL 1151
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|P27046|MA2A1_MOUSE (Alpha-mannosidase 2 OS=Mus musculus OX=10090 GN=Man2a1 PE=1 SV=2) HSP 1 Score: 668.692 bits (1724), Expect = 0.000e+0 Identity = 393/1052 (37.36%), Postives = 600/1052 (57.03%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSL-------KKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAI-KMSQFVFTYAAQRILQN-NIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQ-LAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSL-LNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSY-QLMNDLIYP-VHQMFVKTNFTNSVPS---NLVGQKSLLTGYGLPCDYHLINFKTNINEIPK-------LTIHRLKLNCYAGYISEG---SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y+ + F + DGGVWKQGF ++Y ++ L+VFVVPHSH DPGW+KT ++YF+D TQ I N+M+ L ++ + KF+ +E+ Y KWW+ I +K+ VK L++N QLEIVTGGWVM DEAT HY ++I+QL +GH WL+ NL P +GWAIDPFG+S M YLLK++G ++M+IQRVHY IKK + K LEF W+Q WD + I CHMMPF+SYD+PHTCGPDP ICCQFDF R+ R CPWG P I+ NV+ RA+MLLDQYRKK+ L+ +L PLGDDFR+ EW +Q RNY +L YMN Q V+I+FG LSDYFD+L KK +FP+LSGD F+YADR DHYW+GYFTSRPF K +DRI+ + +RAAEI+ L+L KYK F S + + +RR L LFQHHDA+ GT+K VVVD+ +L ++ + + + A IL++ + S + ++D +S + + I + RY+ ++N Q R +V I + T +K++ + ++ Q++ ++ + + + VSF +I PL + +IL ++ SS H+ Y + N+ +N +N + + ++N + + +G +E V +++L + F YG R+ SGAYLF+PDG+G + G +Y +V + +H ++L+ + G+ ++++ NIV+IR N EI M I + + + ++ D N +Q R+T K+P+Q NVYPM +YI+ D+ ++ LLS QS G ++ G IEVF+DR L QDDNRGL + + DN++ + +R+L E +S N E + + SY L++ + ++ F+ + +PS L+ + LL LPCD HL+N +T +++ K L +HR +C + S G C + K ++K +F+ +++ + SLS D ++ ++ M+I T+ +
Sbjct: 130 MLDVYDLIPFDNPDGGVWKQGFDIKYEADEWDHEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSSRKFMWSEISYLAKWWDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLGVKPRSGWAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLGSATDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSKLFRT-KVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQPHLKVKIQFGTLSDYFDALEKAVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALKQAQKYKI---NKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPQKIIIQLSAQEPRYLVVYNPFEQERHSVVSIRVNSAT----VKVLSDSGKPVEVQVSAVWNDMRTISQAAYEVSFLAHIPPLGLKVFKIL-----ESQSSSSHLADYVLYNNDGLAENGIFHVKNMVDAGDAITIENPFLAIWFD-RSGLMEKVRRKEDSRQHELKVQFLWYGTTNKRDKSGAYLFLPDGQGQPYVSLRPPFVRVTRGRIYSDVTCFLEHVTHKVRLYNIQGIEGQSMEVSNIVNIRNVHNREIVMRISSK-INNQNRYYTDLNGYQIQPRRTMSKLPLQANVYPMCTMAYIQ----DAEHRLTLLSAQSLG---ASSMASGQ----IEVFMDRRLMQDDNRGLGQGVHDNKITANLFRILLEK----RSAVNMEEEKKSPVSYPSLLSHMTSSFLNHPFLPMVLSGQLPSPAFELLSEFPLLQS-SLPCDIHLVNLRTIQSKMGKGYSDEAALILHRKGFDCQ--FSSRGIGLPCSTTQGKMSVLK-LFNKFAVESLVPSSLSLMHSPPDAQNMSEVSLSPMEISTFRIRL 1147
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Match: sp|P49641|MA2A2_HUMAN (Alpha-mannosidase 2x OS=Homo sapiens OX=9606 GN=MAN2A2 PE=2 SV=3) HSP 1 Score: 665.611 bits (1716), Expect = 0.000e+0 Identity = 403/1057 (38.13%), Postives = 592/1057 (56.01%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKY----KYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISD---TYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYG----------LPCDYHLINFKTNINE---IP----KLTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTY 3127
M + E L F + DGGVW+QGF + Y D L+VFVVPHSH DPGWIKT D+Y+ + TQ ILNSM+ L ++P +F+ AEV +F KWW+ I+ ++ V++L+ N QLEI TGGWVM DEA +HY ++I+QL +GH WL+ NL TP +GWA+DPFGYS MPYLL+++ + +M+IQRVHY IKK A++ LEF W+Q WDS++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ NV RA +LLDQYRKK+ L+ N +LVPLGDDFRY +EW Q+ NY +L D+ N + +V+ +FG LSDYFD+L K + FP LSGD FSYADR+DHYWTGY+TSRPF K LDR+L HLR AE++ SL+ + + +Y LS +LL E +RRTL LFQHHDA+ GT+K VVVD+ +LL ++ + V +AA ++ + FD VD+ + + + I + ++ R+V LFN L Q R +V + V++ R ++++ Q + QI+ + A E + + VS + + A + D T SSV I+L+ + S++ + F + +S + + L N ++ + TG ++ + + + + ++++ YG R S++ SGAYLF+PDGE + EG + EVVA + ++L+ + G+ ++DI ++VDIR N E+++ I TD + FF D N FQ R+ K+P+Q N YPM +YI+ D+ +++ L + Q+ GV ++ G +EV LDR L QDDNRGL + L DN+ +RLL E + G S Q + YP + + + N+ L + L G G LPCD+HL+N +T E +P L +HR +C + G +C + K L S+F + + ++ SL+ + D+ + M+I T+
Sbjct: 131 MLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLF-RSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDF---TLLTE----ARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSS-PRFVVLFNPLEQERFSMVS--LLVNSPR--VRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLP--ALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDF-ALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTD-IDSQGIFFTDLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQ----DAQKRLTLHTAQALGV---SSLKDGQ----LEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLE---------RRTVG----SEVQDSHSTSYPSLLSHLTSMYLNAPALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAKNLGFNCTTSQGKVAL-GSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPMEIATF 1145
BLAST of Alpha-mannosidase vs. TrEMBL
Match: R7UWP9 (Alpha-mannosidase OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_167403 PE=3 SV=1) HSP 1 Score: 710.679 bits (1833), Expect = 0.000e+0 Identity = 415/1020 (40.69%), Postives = 598/1020 (58.63%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQI--IFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIF-QLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSV--HIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQ-LKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEIPKLT-IHR----LKLNCYAGYISEG----SCKFLRKKSPLMKSMFDDVSIKYVNKFSLS 3055
M +Y+ L F + DGG WKQGF + Y+ LKVFVVPHSH DPGW+KT D Y+ + T+ IL++ML+ L P M+FI+AE+ +F WW IS +++ +VK LIK +LE+VT GWVMTDEA AHY +M++QL +G+ WL N++ P +GWAIDPFGYS MPYLLK+SG NNM+IQRVHY +KK LA K+LEFRW+Q WD + CH+MPF+SYDVPHTCGPDP +CCQFDF R+ + CPW PV IT +NV RAEMLLDQYRKKA+LY N N VL+PLGDDFR+ EW QY NY +L D++N N + +FG LSDYF +L + + + +P LSGD FSYADR DHYWTGYFTSRPF K LDRIL +LR AEI+ SL++ Y K + F + L + + +RR+L LFQHHDA+ GT+K V+VD+ ++LL+A++ + V T +A +L + + + FDVD +S + I + ++ V +NSLS R ++ + V+T + + SGN +I Q++P + E ++ + + F +++ PL I T + + +++ L +++ + F + + K ++NS ++ TG ++ V S + + + F +YG R++E SGAYLF+PDG+ IE++ T V +G L EV HI++L GL S ++++ NIVDI KE+N E+ M + +D V D+ F D N FQ +RKT+ K+P+Q NVYPM +YI+ D +++ LLS QS GV G ++EVF DR L+QDDNRGL + ++DN+ +R++FE K+ KS N+ G ++ + ++LI+PVH + VK F +S Q LPC+ HL+N ++ + +L I R L L +A S +C K + S+F+D+ IK LS
Sbjct: 1 MQNVYDQLPFKNIDGGAWKQGFSISYSDTQFSSQPLKVFVVPHSHCDPGWVKTFDRYYSEQTRHILDNMLEKLEAYPKMRFIYAEISFFSMWWQEISVDKQRRVKNLIKEGRLELVTAGWVMTDEANAHYYAMLDQLIEGNQWLLNHIGVIPESGWAIDPFGYSPTMPYLLKRSGFNNMLIQRVHYEVKKYLAEEKKLEFRWRQTWDHSGTTDMFCHLMPFYSYDVPHTCGPDPKVCCQFDFKRLPGGKVSCPWNVPPVPITPQNVADRAEMLLDQYRKKAMLYKN-NVVLIPLGDDFRFDKAVEWDQQYSNYQQLFDFINNTPRLNAQAQFGTLSDYFHALHERAGTAVNEVPESYPVLSGDFFSYADRDDHYWTGYFTSRPFYKRLDRILEANLRGAEILYSLAVSYARKLQLA---NFPEKQLMQPLVMARRSLGLFQHHDAITGTAKDFVMVDYGHKLLSALQNMKTVITESAHFLLVKDRTHYVYSSTRPFFDVDETRSTHDSLPAKTTI-VLSDKPVPVAFYNSLSHTRNCVIR--LYVNTPHVEVHD-PSGN-VIVSQVDPFWVSNEEMSSELYKLHFVVSVPPLGLASYSITKTAVGSNHKNTLGSTTFLNSVRKAKLINNAFLI---DVFDGKEFSIQNSEMTASFSAATGMLKHVTSKSSNQEVDVALQFLRYGVARTKEKSGAYLFLPDGQAQPIEYNKPFTRV-IQGPLVSEVHVIIPNVEHIVRLHNSPGLDSLSLEVSNIVDISKETNKELIMRVISD-VQNGDQLFTDLNGFQIHQRKTYSKLPLQANVYPMPTMAYIQ----DHHKRLSLLSAQSLGV-------AGLQSGWLEVFQDRRLSQDDNRGLGQGVLDNKRTPTKFRMMFEFLKEDAKSPPNQAAGYPSLQAQLASSELIHPVHVLPVKNPFGSSAQLAPTFQP---LSQQLPCEVHLVNLRSLQGDTAELEFIPRQDFGLILQTHAADCSLPTRGLTCPTTAAKI-TIGSLFEDIRIKEAKSSILS 991
BLAST of Alpha-mannosidase vs. TrEMBL
Match: A0A3Q2UIM7 (Alpha-mannosidase OS=Gallus gallus OX=9031 GN=MAN2A1 PE=3 SV=1) HSP 1 Score: 701.819 bits (1810), Expect = 0.000e+0 Identity = 414/1058 (39.13%), Postives = 610/1058 (57.66%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKD-------KIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIG----------IKIMGSGNQLIKCQINPIFQLAEFNNNQHF-VSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKN--FQVSS-ENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEF-TVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEI-------PKLTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y+ L F + DGGVWKQGF + Y + L+VFVVPHSH DPGW+KT D+YF+D TQ ILN+M+ L ++ KFI +E+ YF KWW+ I ++D VK+LIK+ Q EIVTGGWVM DEA+AHY S+I+QL +GH WL+ NL P +GWA+DPFG+S M YLLK++G +NM+IQR+HY +KK ++ K LEF W+Q WD + I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P I N++ RA M+LDQYRKK+ L+ +L PLGDDFRY EW QY+NY KL DYMN E++V+ +FG LSDYF++L+K+ +FP LSGD F+YADR HYW+GYFTSRPF K LDR+L +HLRAAEI+ SL+LI +KY +VF ++ + +RR L LFQHHDA+ GTSK VVVD+ +L +++ + V +A ++ + G +D +D+++S + I + SQPR LL+H P D ER +K++ + + QI+ ++ A +++ + VSF ++ PL ++L S+ + +I++ ++S+ K + F++ +NS+ N ++L+NS KL + T+G +E + +++ + F YG +R+ SGAYLF+PDG+ F T+ G+++ EVV +H ++L+ V GL ++++ NIVDIR E N E++M I +D + + F+VD N +Q R T K+P+Q N+YPMT +YI+ DS ++ L S QS GV K +EV +DR L QDDNRGL + + DN++ + +RLL E + K F ++ S+ + L +PV M TN + VP L L++ +PCD H++N +T +++ L +HR +C G C + K + K +F+ S++ + SLS D +I M+ M+I+T+ +
Sbjct: 133 MLDVYDILPFDNPDGGVWKQGFDITYNENEWDSAPLQVFVVPHSHNDPGWLKTFDDYFRDQTQHILNNMVIKLQEDNRRKFIWSEISYFSKWWDGIDSQRRDAVKRLIKDGQFEIVTGGWVMPDEASAHYFSLIDQLIEGHQWLERNLGVKPKSGWAVDPFGHSPTMAYLLKRAGFSNMLIQRIHYSVKKYFSAQKTLEFFWRQNWDLGSSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRVSCPWRVPPEAIHSGNIQHRAWMILDQYRKKSKLF-RTKVLLAPLGDDFRYAESSEWDQQYQNYQKLFDYMNTHPEFHVKAQFGTLSDYFEALRKESNLGEGSSSPLFPVLSGDFFTYADRDHHYWSGYFTSRPFYKRLDRVLESHLRAAEILYSLALI--QSHKYNKMSVFPSVDNYKLLTEARRNLGLFQHHDAITGTSKDWVVVDYGTRLFHSLMNVKKVIIDSAHILILKDKGAYNYDTSTPFLKMDDVQSSQDSLPHKTVIKLT-------------SQPRYLLIHNP--TDQERFSVVSVIVSSPRVKLLSPLGKPVTVQISAVWDGATTVSHEAYQVSFLAHLPPLGLGVYQLLEVPSSEANLAEYNIYMSG-RDSVQEKSDRIFKIKEMQNSVDN--IILENSYMKLWFSGTSGLLEKINTKEDGKNHQMKVEFAWYGTTSNRDKSGAYLFLPDGDAKPYIFTDPPTVRVAHGKIFSEVVCFFHHVTHTMRLYNVQGLEGQSLEVSNIVDIRGEYNRELAMRISSD-INSRNRFYVDLNGYQIQPRLTMSKLPLQANIYPMTTMAYIQ----DSGVRLTLHSAQSLGVASLKN-------GQLEVIMDRRLMQDDNRGLGQGVQDNKITANVFRLLLERRHGTDVNEEKASVSFPSLLSHMTSSFLNHPVIPM--TTNADSGVPEMLNMFSPLMS--SMPCDIHIVNLRTIQSKVDTEPSDEAALILHRKGFDCRFSNRDVGLLCSTTQGKVRVHK-LFNKFSVESLTPASLSLMHSPPDARNMSEINMSSMEINTFRIRL 1152
BLAST of Alpha-mannosidase vs. TrEMBL
Match: A0A2I0UFF9 (Alpha-mannosidase OS=Limosa lapponica baueri OX=1758121 GN=llap_4919 PE=3 SV=1) HSP 1 Score: 698.353 bits (1801), Expect = 0.000e+0 Identity = 412/1049 (39.28%), Postives = 612/1049 (58.34%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKD-------KIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYK--YGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF-VSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSS-ENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEF-TVSSYQLMNDLIYPVHQMFVKTNFTNS-VPSNLVGQKSLLTGYGLPCDYHLINFKTNINEI-------PKLTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y+ L F + DGGVWKQGF + Y + L+VFVVPHSH DPGW+KT D+YF+D TQ ILN+M+ L ++ KFI +E+ YF KWW+ I +KD VK+LIK+ Q EIVTGGWVM DEA+ HY ++I+QL +GH WL+ NL P +GWA+DPFG+S M YLLK++G +NM+IQRVHY +KK A+ K LEF W+Q WD + I CHMMPF+SYD+PHTCGPDP ICCQFDF R+ R CPW P I NV+ RA M+LDQYRKK+ L+ +L PLGDDFRY EW QY+NY KL DYMN EW+V+ +FG LSDYF++L+K+ FP LSGD F+YADR HYW+GYFTSRPF K LDR+L ++LRAAEI+ SL+L+ +K + +V N LL E +RR L LFQHHDA+ GTSK VVVD+ +L ++I + V +A ++ + G +D +D+++S + + I + T+ RY+ ++N Q R +V + V++ R IKI+ + + QI+ ++ A +++ + +SF +++ PL ++L S+ + ++++ N + K F+++ +NS+ N ++L+NS KL + +G +E + +++ + F YG +R+ SGAYLF+PDG+ F TI G+++ EVV +H ++L+KV GL ++++ NIVDIR E N E++M I +D + + F+ D N +Q R T K+P+Q N+YPMT +YI+ D ++ L S QS GV K +EV +DR L QDDNRGL + + DN++ + +RLL E ++K F ++ S+ + L +PV M T + ++ VP L L++ +PCD H++N +T +++ L +HR +C G C + K + K +F+ ++ + SLS D +I M+ M+I+T+ +
Sbjct: 125 MLDVYDILPFDNPDGGVWKQGFDITYNENEWDSEPLQVFVVPHSHNDPGWLKTFDDYFRDQTQHILNNMVIKLQEDNRRKFIWSEISYFSKWWDAIDSQKKDAVKRLIKDGQFEIVTGGWVMPDEASPHYFALIDQLIEGHQWLEKNLGVKPKSGWAVDPFGHSPTMAYLLKRTGFSNMLIQRVHYSVKKHFATQKTLEFFWRQNWDLGSSTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRVSCPWRVPPEAIHAGNVQHRAWMILDQYRKKSKLF-RTKVLLAPLGDDFRYAESSEWDQQYQNYQKLFDYMNSHPEWHVKAQFGTLSDYFEALRKESNLGEKSSNSFFPVLSGDFFTYADRDHHYWSGYFTSRPFYKRLDRVLESYLRAAEILYSLALVQSSKSEKMSVFPSVDNYKLLTE----ARRNLGLFQHHDAITGTSKDWVVVDYGTRLFHSIMNLKKVIIDSAHILILKDKGAYNYDTSTPFLKMDDVQSSQDSLPRKTVIKL-TSQPRYLLIYNPTEQERFSVVS--VNVNSPR--IKILSPVGKPVTVQISAVWDGATTVSHEAYQISFVVHLPPLGLGVYQMLEVQSSEAVLADYNLYMRNSRQEKP-DKLFKITEMQNSVDN--IILENSYMKLWFSGMSGLLEKINTKEDGKNHQMKVEFAWYGTTSNRDKSGAYLFLPDGDAKPYIFTDPPTIRVSHGKIFSEVVCFFHHVTHTMRLYKVQGLEGQSLEVSNIVDIRGEYNRELAMRISSD-INSQNRFYTDLNGYQIQPRLTMSKLPLQANIYPMTTMAYIQ----DVGVRLTLHSAQSLGVASLKN-------GQLEVIMDRRLMQDDNRGLGQGVQDNKITANIFRLLLERRYGTDVNEDKASVSFPSLLSHMTSSFLNHPVIPM---TTYADAGVPEMLNTFSPLMS--SMPCDMHIVNLRTIQSKVDIEPSDEAALILHRKGFDCRFSNRDTGLLCSTTQGKIKVHK-LFNKFRVESLTPTSLSLMHSPPDARNISEINMSSMEINTFRIRL 1142
BLAST of Alpha-mannosidase vs. TrEMBL
Match: A0A0R4IVS5 (Alpha-mannosidase OS=Danio rerio OX=7955 GN=man2a1 PE=1 SV=1) HSP 1 Score: 697.582 bits (1799), Expect = 0.000e+0 Identity = 400/1056 (37.88%), Postives = 601/1056 (56.91%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK----DKIKM------FPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF-VSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVS------SYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT--------NINEIPKLTIHRLKLNCYAGYISEGS---CKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y+ L F + DGGVWKQGF + Y + L+VFVVPHSH DPGW+KT D+Y++D TQ ILN+M+ L ++ K I +E+ YF KWW++I ++D V++L++N QLE+ TGGWVM DEA AHY +MI+QL +GH WL+ NL P TGWA+DPFG++ YLLK +G++NM+IQRVHY +KK +S K LEF W+Q WD ++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P ITD NV+ RA+ LLDQYRKK+ L+ +L PLGDDFRY EW Q+ NY KL DYMN E +V+ +FG +SDYF +L+K D + M P +SGD F+YADR DHYW+GYFTSRPF K +DR+L ++LRAAE++ SL+L N KYG + + ++ + +RR L LFQHHDA+AGT K VVVD+ +L ++I + V +A ++ + D + +D+++ + + N + + R + + N L Q R +V + + ++++ + Q+++ Q++ +++ A F +SF + PL +++ T S + S + ++F+ ++ VV++N +L I+ TG +E + +S++++ + F YG S++ SGAYLF+PD E +I I +G L+ EV +H L+L+ G+ +++I N VDIR E+N EI+M I +D + D FF D N +Q RKT K+P+Q N YPMT Y++ DS+ ++ LL+ QS G K+ +EV +DR LNQDDNRGL + ++DN++ + +RLL E K++ +N+ ++ SY +N +P+ M V + PS +V L + PCD HL+N + +E L +HR +C G+ + + C R K L K + D+ +K + SLS + + +P++I + M+I TY +
Sbjct: 129 MLDVYDLLRFDNPDGGVWKQGFDISYQENEWDNEPLQVFVVPHSHNDPGWLKTFDDYYRDQTQHILNNMVVKLHEDSRRKMIWSEISYFAKWWDSIDGQKQDAVRRLVENGQLEVATGGWVMPDEANAHYFAMIDQLVEGHQWLERNLGVKPKTGWAVDPFGHTATQAYLLKLAGLSNMLIQRVHYSVKKHFSSQKTLEFFWRQNWDQDSSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRISCPWRIPPQAITDNNVQERAQTLLDQYRKKSKLFRT-KVLLAPLGDDFRYTEAVEWDQQFENYQKLFDYMNSHPELHVKAQFGTISDYFQALRKSTGMDPVGMNVGHLALPVVSGDFFTYADRDDHYWSGYFTSRPFYKRMDRMLESYLRAAEVLYSLTLA--NIQKYGQPSDYPAGENYKLLTEARRNLGLFQHHDAIAGTGKDWVVVDYGTRLFHSILNVKRVIVSSAHWLVLKDKQTYHNDPSKAFLQMDDVQQSQDALPRKNVLEVH-GKPRLLVVSNPLEQARTSMVTVYVNTPN----VRVVSALGQVVRAQVSAVWKDASHATADVFQLSFVAHAAPLGLSVYQLIEVMEPRTDASKYMFLQEGRQLSDSKLEHFRQFYQDD--GAPVVIENPHLRLSISGATGLLEKMMLKEDESEHQMKVEFVWYGTTSSKDKSGAYLFLPDKEATIYSPSQPPVIRVTKGTLFSEVTTTFAHITHTLRLYNTQGVEGQSVEICNTVDIRGETNREIAMRITSDLNS-KDRFFTDLNGYQVQPRKTMAKLPLQANFYPMTSMLYLQ----DSSARLSLLTAQSLGAASLKS-------GQLEVIMDRRLNQDDNRGLGQGVLDNKITANSFRLLLE--KRISVEENEATAPYSYPSILSHMSYMYLN---HPLISMAVSQHL--EAPS-VVPYSPLKASF--PCDMHLVNLRAIQSKEEGGAASEQAALILHRKGFDC--GFSNRNTGLLCTSTRGKIDLEK-LLTDLKVKSITPVSLSLMHTLSSESRPQEISLKAMEIRTYRLEL 1149
BLAST of Alpha-mannosidase vs. TrEMBL
Match: A0A2Y9JRQ0 (Alpha-mannosidase OS=Enhydra lutris kenyoni OX=391180 GN=LOC111148294 PE=3 SV=1) HSP 1 Score: 697.197 bits (1798), Expect = 0.000e+0 Identity = 412/1047 (39.35%), Postives = 602/1047 (57.50%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRII--YFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKI-------KMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRIL---QNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAE-FNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFK-KNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDL--IYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEI-------PKLTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y + F + DGGVWKQGF + Y + L+VFVVPHSH DPGW+KT D+YF++ TQ I N+M+ L ++ KF+ +E+ Y KWW+TI K +KD +K L++N Q EIVTGGWVM DEA AHY ++I+QL +GH WL+ NL P +GW+IDPFG+S M YLLK++G ++M+IQRVHY IKK A K LEF W+Q WD + I CHMMPF+SYD+PHTCGPDP ICCQFDF R+ F CPWG P I NV+ RAEMLLDQYRKK+ L+ VL PLGDDFRY EW QY+NY L DYMN E+NV+I+FG LSDYFD+L K+ + MFP LSGD F+YADR DHYW+GYFTSRPF K +DRIL +HLRAAEI+ +L KYK + F S + + +RR L LFQHHDA+ GT+K VVVD+ +L +++ + + Y+A ++ +N+ + FD ++ D+D LK S+ + + + RY+ + N Q R +V + + T ++ + + ++ Q++ ++ A + + +SF + I PL + IL + SD + + +H NIK+ F KN + + E+ ++L+NS KL +G +E + + ++++ + F YG ++ SGAYLF+PDGE + +L + G Y +V + +H ++L+ + G+ ++++ NIVDIRKE N EI+M I + + + F+ D N +Q R T K+P+Q NVYPMT +YI+ D+ ++ LLS QS GV K+ IEV +DR L QDDNRGL + + DN+V + +R+L E +S N E + +VS L++ + + H +F T L+G+ S L LPCD HLIN +T +++ L +HR +C G + L++ +F ++ + SLS D +I ++ M+I T+ +
Sbjct: 83 MLDVYSLIPFDNPDGGVWKQGFDISYLFNEWDSKPLQVFVVPHSHNDPGWLKTFDDYFREMTQYIFNNMVIKLKEDSRRKFMWSEISYLSKWWDTIDKPKKDAIKSLLQNGQFEIVTGGWVMPDEAAAHYFALIDQLIEGHQWLEKNLGVKPRSGWSIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFALHKTLEFFWRQNWDLGSGTDIFCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHLGNVQKRAEMLLDQYRKKSKLF-RTTVVLAPLGDDFRYCERTEWDHQYKNYQLLFDYMNSHPEYNVKIQFGTLSDYFDALDKEDVAIRKNSQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRILESHLRAAEILYYFALKQAQKYKI---SKFLSSSHYMTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLTNLKKIIGYSALLLILKDKNSYNSYSFDNLL-DMD-LKQNSQSSLPQKTVIMLSAEPRYLVVCNPSEQERISVVSVYVSSPTAQVS----SASGKPVEIQMSAVWNTASTISQTAYEISFLVQIPPLGLKVYTILESASSDPHLTEYVLHNGNIKDKGIFNMKNVKSTDED------IILENSFVKLRFGQ-SGLMEEMINKEDGKRHEVKVQFSWYGTTSKKDKSGAYLFLPDGEAKPYVYTALPFVRVQHGRFYSDVTCFLEHVTHRVRLYNIQGIDGQSVEVSNIVDIRKEHNREIAMRISSS-INSQNRFYTDLNGYQIQPRMTMSKLPLQANVYPMTTMAYIQ----DAKHRLTLLSAQSLGVSSLKS-------GQIEVIMDRRLMQDDNRGLEQGVHDNKVTANLFRILLEK----RSVVNMEEEKKSVSYPSLVSHVTSFFLNHPVFTMTEKIPVPTLKLLGEFSPLLS-SLPCDIHLINLRTIQSKVDGKHSDEAALILHRKGFDCRFSSRDTGLLCSTTQGKILVQKLFSMFTVTSLIPSSLSLMHSPPDARNISEINLSPMEISTFRIQL 1095
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: man2a1 (mannosidase alpha class 2A member 1 [Source:NCBI gene;Acc:103023301]) HSP 1 Score: 693.345 bits (1788), Expect = 0.000e+0 Identity = 395/1048 (37.69%), Postives = 599/1048 (57.16%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDK----------IKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD--QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF-VSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKN-SMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT-------NINEIPKLTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
M +Y+ L F + DGGVWKQGF + Y + L V VVPHSH DPGW+KT D+YF+D TQ ILN+M+ L+++ K I +E+ YF KWW+ I ++D VKKLI+ QLEI TGGWVM DEA +HYS+MI+QL +GH WL+ N+ P TGWA+DPFG+S Y+LK++G++NM+IQRVHY IKK ++ K LEF W+Q WD ++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ENV+ RA+MLLDQYRKK+ L+ VLVPLGDDFRY +EW Q+ NY L DYMN E +V+ +FG +SDYF+ L+K P++SGD F+YADR DHYW+GYFTSRPF K +DRIL +HLRAAEI+ SL+L + ++G + + ++ + G+RR L LFQHHDA+AGT K V+VD+ +L +++ + V +A ++ ++ +D + +D+++ + + + I + R + + N Q R +V+I + ++++ + L+ QI+ +++ A + + F +SF N+ PL V L G+ S+ ++ L + S++ +F+VS+ + + V+++N +L I+++TG ++ ++ S++ + + F YG +++ SGAYLF+PDGE I +G ++ EV +H ++L+ V G+ ++I NIVDIR E N EI+M I +D + D FF D N FQ R+ K+P+Q N YPMT +YIE DS R++ LL+ QS +G T K + EV +DR LNQDDNRG+ + ++DN++ + +RL+ E + + + S + +Y H + +S L L + + PCD HL+N +T ++ L +HR +C + G C R K + + + ++ + + SLS + ++I + M+I TY +
Sbjct: 131 MMDVYDLLSFDNPDGGVWKQGFDISYEENEWDNEPLHVVVVPHSHNDPGWLKTFDDYFRDQTQHILNNMVVKLLEDVRRKMIWSEISYFAKWWDNIDSQKRDSVKKLIERGQLEIATGGWVMPDEANSHYSAMIDQLLEGHQWLEKNVGVKPRTGWAVDPFGHSSTQAYILKQAGLSNMLIQRVHYSIKKHFSTQKTLEFFWRQNWDHDSSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRISCPWRIPPEPITNENVQQRAKMLLDQYRKKSKLF-RTKVVLVPLGDDFRYTEAQEWDQQFNNYQMLFDYMNSHSELHVQAQFGTISDYFEILRKKAGINEAGMSVGESQLPTVSGDFFTYADRDDHYWSGYFTSRPFYKRMDRILESHLRAAEILYSLALA--STRRFGRPSDYPAVENYKLLTGARRNLGLFQHHDAIAGTGKDWVMVDYGTRLFHSLLNVKRVIASSAHWLVLDDKKAYTYDPSNPVLQIDDVQPAQDSLPRKTVLKI-SKTPRSLVVHNPSEQSRSSVVNIYVNTPH----VRVLTADGHLVIAQISAVWEDATRASTEAFQLSFVANVPPLGLA-VYQLIQGLELQTESAQYLFLKDGGAVSVSGMDHFKVSTPQNAVP--VLIENPHLQLSISASTGLMKTLKLKEDGSEHSVRVEFLWYGTTSNKDKSGAYLFLPDGEAKKYIPSQPPVIRVTKGPVFSEVTTTFTHVTHTVRLYNVKGVDGQAVEISNIVDIRAEFNREIAMRIISD-IGSKDRFFTDLNGFQMQPRRAMAKLPLQANFYPMTSMAYIE----DSLRRLTLLTAQS----LGATSLKSGQL---EVIMDRRLNQDDNRGMGQGVLDNKITANLFRLVLEPRNPTQETKRENTTPLSYPSLRNHISYMYLNHPLMPMATTWDSDMLTLTPYSPLSSSF--PCDIHLVNLRTIQSQEGEGPSDQAALILHRKAFDCNIATSNTGLLCSTTRGKIEI-QELLSELKVSSLEPMSLSLMHESSSRAVDQEITLKPMEIHTYRIQL 1152
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: man2a2 (mannosidase alpha class 2A member 2 [Source:NCBI gene;Acc:103041860]) HSP 1 Score: 663.685 bits (1711), Expect = 0.000e+0 Identity = 394/1053 (37.42%), Postives = 589/1053 (55.94%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYK--YGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQI--IFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISD-TYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPV--HQMFVKTNFTNSVPSNLVGQKSLLT----GYGLPCDYHLINFKTNINEIPK-------LTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSL----SGNQVIGDKVKPEDICMNLMDIDTY 3127
M +Y L F + DGGVWKQGF++ Y + L+VFVVPHSH DPGW+KT D+Y+ D Q I N+M+ L ++P KFI +E+ +F KWW++ ++++ ++KLI QLEIVTGGWVMTDEA AHY +MI+QL +GH WL+ NL P +GWA+DPFG+S MPYLLKK+ + +M+IQR+HY IKK +S++ LEF W+Q WD E+ + CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P ITD NV RA +LLDQYRKK+ L+ VL+PLGDDFRY EW QY NY KL DYMN E +V+ +FG L+DYF+++ K + +P LSGD F+YADR+DHYW+GY+TSRPF K LDRIL +HLR AEI+ SL+ + H ++ G + SLL + +RR + LFQHHDA+AGT+K VV D+ +LL ++ + V AA ++ N +F Q + D+ ++ + + I + ++ RY+ LFN + Q R L + + V++ + ++++ Q + Q++ + A + + + SF + L + + S T S + L ++ V S+ + + + SL L + TTG +E + + ++ + F YG R S++ SGAYLF+PDG + EG L+ EVV + F +++ V G+ ++DI +VDIR ++N E+SM + TD + D F+ D N FQ R+ F K+P+Q N YPM +YI+ DS ++ L + Q+ GV ++ G +EV LDR L QDDNRGL + + DN+ + +RLL E ++ ++ VS L++ + + H++ +P G L T LPCD+ L+N ++ N+ + L +HRL L+C + G +C + K + ++F + ++ + SL SG + + I + M++ TY
Sbjct: 131 MLDVYSLLSFDNVDGGVWKQGFEITYEPSEWDSEPLQVFVVPHSHNDPGWVKTFDKYYNDQMQHIFNNMVVKLAEDPRRKFILSEISFFVKWWDSADAHKQEAIRKLILGGQLEIVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGVIPRSGWAVDPFGHSATMPYLLKKANVTSMLIQRIHYSIKKHFSSTRSLEFMWRQAWDPESGTDLFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAITDANVAERANVLLDQYRKKSKLF-RSKVVLIPLGDDFRYDKSLEWDQQYINYQKLFDYMNSHPEMHVQAQFGTLTDYFNAVYKANGVSQGARPPGYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYSLA-VSHARHAGMEGRYPTSDYSLLTD----ARRNIGLFQHHDAIAGTAKEAVVTDYGTRLLRSLIGLKRVIINAAHFLIMKNKDVYRFYQTEPFLETDDRRATQDSLPQRTLIELDSS-PRYLVLFNPVEQER--LCVVTVLVNSAK--VRVLTEDGQTLPVQLSAQWSSAVQMSGEVYQASFMARLPALGLAVFHLYDSVDSPMTLRSDTLLRLPGRSQTVRGVDPLPVRSQIADPQPFYIQTQSL-TLAFSGTTGLLESIRRKDDPQEVRVQVQFFTYGTRPSKDKSGAYLFLPDGNAKPYTQRDPPIVRVVEGPLFAEVVTYYQHFQQTVRIHNVPGVDGLSLDITTLVDIRDQTNKELSMRLHTD-IQSEDTFYTDLNGFQIQPRRYFQKLPLQANFYPMPTMAYIQ----DSQYRLTLHTAQALGV---TSLASGQ----LEVMLDRRLMQDDNRGLGQGVKDNKRTANRFRLLLER----RTSSSRAVDSGPVSFPSLLSHMTSSILNHEVLA----LPVIPKKR-GVPPLRTFAPLANALPCDFRLLNLRSIQNQDAQSPSLYTALLLHRLGLDCGLEAQNPGFNCTTTQGKL-AVSALFRGLDLQLLQPMSLTLMYSGTPLSNSSI----ISLEPMELSTY 1145
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: man2a2 (mannosidase alpha class 2A member 2 [Source:NCBI gene;Acc:103041860]) HSP 1 Score: 663.685 bits (1711), Expect = 0.000e+0 Identity = 398/1075 (37.02%), Postives = 598/1075 (55.63%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYK--YGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQI--IFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISD-TYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIY--------------PVHQMFVKTNFTNSVPSNLV----------GQKSLLT----GYGLPCDYHLINFKTNINEIPK-------LTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFDDVSIKYVNKFSL----SGNQVIGDKVKPEDICMNLMDIDTY 3127
M +Y L F + DGGVWKQGF++ Y + L+VFVVPHSH DPGW+KT D+Y+ D Q I N+M+ L ++P KFI +E+ +F KWW++ ++++ ++KLI QLEIVTGGWVMTDEA AHY +MI+QL +GH WL+ NL P +GWA+DPFG+S MPYLLKK+ + +M+IQR+HY IKK +S++ LEF W+Q WD E+ + CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P ITD NV RA +LLDQYRKK+ L+ VL+PLGDDFRY EW QY NY KL DYMN E +V+ +FG L+DYF+++ K + +P LSGD F+YADR+DHYW+GY+TSRPF K LDRIL +HLR AEI+ SL+ + H ++ G + SLL + +RR + LFQHHDA+AGT+K VV D+ +LL ++ + V AA ++ N +F Q + D+ ++ + + I + ++ RY+ LFN + Q R L + + V++ + ++++ Q + Q++ + A + + + SF + L + + S T S + L ++ V S+ + + + SL L + TTG +E + + ++ + F YG R S++ SGAYLF+PDG + EG L+ EVV + F +++ V G+ ++DI +VDIR ++N E+SM + TD + D F+ D N FQ R+ F K+P+Q N YPM +YI+ DS ++ L + Q+ GV ++ G +EV LDR L QDDNRGL + + DN+ + +RLL E ++ ++ G + S+ ++N +I PV + ++ T+S+ ++ V G L T LPCD+ L+N ++ N+ + L +HRL L+C + G +C + K + ++F + ++ + SL SG + + I + M++ TY
Sbjct: 131 MLDVYSLLSFDNVDGGVWKQGFEITYEPSEWDSEPLQVFVVPHSHNDPGWVKTFDKYYNDQMQHIFNNMVVKLAEDPRRKFILSEISFFVKWWDSADAHKQEAIRKLILGGQLEIVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGVIPRSGWAVDPFGHSATMPYLLKKANVTSMLIQRIHYSIKKHFSSTRSLEFMWRQAWDPESGTDLFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAITDANVAERANVLLDQYRKKSKLF-RSKVVLIPLGDDFRYDKSLEWDQQYINYQKLFDYMNSHPEMHVQAQFGTLTDYFNAVYKANGVSQGARPPGYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYSLA-VSHARHAGMEGRYPTSDYSLLTD----ARRNIGLFQHHDAIAGTAKEAVVTDYGTRLLRSLIGLKRVIINAAHFLIMKNKDVYRFYQTEPFLETDDRRATQDSLPQRTLIELDSS-PRYLVLFNPVEQER--LCVVTVLVNSAK--VRVLTEDGQTLPVQLSAQWSSAVQMSGEVYQASFMARLPALGLAVFHLYDSVDSPMTLRSDTLLRLPGRSQTVRGVDPLPVRSQIADPQPFYIQTQSL-TLAFSGTTGLLESIRRKDDPQEVRVQVQFFTYGTRPSKDKSGAYLFLPDGNAKPYTQRDPPIVRVVEGPLFAEVVTYYQHFQQTVRIHNVPGVDGLSLDITTLVDIRDQTNKELSMRLHTD-IQSEDTFYTDLNGFQIQPRRYFQKLPLQANFYPMPTMAYIQ----DSQYRLTLHTAQALGV---TSLASGQ----LEVMLDRRLMQDDNRGLGQGVKDNKRTANRFRLLLER----RTSSSRPVGSYAKVSH-MLNKIISHVFGDTEKEAVDSGPVSFPSLLSHMTSSILNHEVLALPVIPKKRGVPPLRTFAPLANALPCDFRLLNLRSIQNQDAQSPSLYTALLLHRLGLDCGLEAQNPGFNCTTTQGKL-AVSALFRGLDLQLLQPMSLTLMYSGTPLSNSSI----ISLEPMELSTY 1171
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: man2a1 (mannosidase alpha class 2A member 1 [Source:NCBI gene;Acc:103023301]) HSP 1 Score: 516.538 bits (1329), Expect = 3.807e-165 Identity = 248/466 (53.22%), Postives = 322/466 (69.10%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDK----------IKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLL 1429
M +Y+ L F + DGGVWKQGF + Y + L V VVPHSH DPGW+KT D+YF+D TQ ILN+M+ L+++ K I +E+ YF KWW+ I ++D VKKLI+ QLEI TGGWVM DEA +HYS+MI+QL +GH WL+ N+ P TGWA+DPFG+S Y+LK++G++NM+IQRVHY IKK ++ K LEF W+Q WD ++ I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P IT+ENV+ RA+MLLDQYRKK+ L+ VLVPLGDDFRY +EW Q+ NY L DYMN E +V+ +FG +SDYF+ L+K P++SGD F+YADR DHYW+GYFTSRPF K +DRIL +HLRAAEI+ SL+L + ++G + + ++ + G+RR L LFQHHDA+AGT K V+VD+ + L
Sbjct: 131 MMDVYDLLSFDNPDGGVWKQGFDISYEENEWDNEPLHVVVVPHSHNDPGWLKTFDDYFRDQTQHILNNMVVKLLEDVRRKMIWSEISYFAKWWDNIDSQKRDSVKKLIERGQLEIATGGWVMPDEANSHYSAMIDQLLEGHQWLEKNVGVKPRTGWAVDPFGHSSTQAYILKQAGLSNMLIQRVHYSIKKHFSTQKTLEFFWRQNWDHDSSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRISCPWRIPPEPITNENVQQRAKMLLDQYRKKSKLFRT-KVVLVPLGDDFRYTEAQEWDQQFNNYQMLFDYMNSHSELHVQAQFGTISDYFEILRKKAGINEAGMSVGESQLPTVSGDFFTYADRDDHYWSGYFTSRPFYKRMDRILESHLRAAEILYSLALA--STRRFGRPSDYPAVENYKLLTGARRNLGLFQHHDAIAGTGKDWVMVDYGTRSL 593 HSP 2 Score: 182.185 bits (461), Expect = 2.722e-46 Identity = 145/525 (27.62%), Postives = 256/525 (48.76%), Query Frame = 2
Query: 1595 GERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKN-SMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT---NINEIPK----LTIHRLKLNCYAGYISEG-SCKFLRKKSPLMKSMFD-DVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHF 3139
G R + + N Q R +V+I + ++++ + L+ QI+ +++ A + + +SF N+ PL V L G+ S+ ++ L + S++ +F+VS+ + + V+++N +L I+++TG ++ ++ S++ + + F YG +++ SGAYLF+PDGE I +G ++ EV +H ++L+ V G+ ++I NIVDIR E N EI+M I +D + D FF D N FQ R+ K+P+Q N YPMT +YIE DS R++ LL+ QS +G T K + EV +DR LNQDDNRG+ + ++DN++ + +RL+ E ++ + + S + +Y H + +S L L + + PCD HL+N +T + E P L +HR +C + G C R K L +++ + + + + SLS + ++I + M+I TY +
Sbjct: 589 GTRSLVVHNPSEQSRSSVVNIYVNTPH----VRVLTADGHLVIAQISAVWEDATRASTE--LSFVANVPPLGLA-VYQLIQGLELQTESAQYLFLKDGGAVSVSGMDHFKVSTPQNAVP--VLIENPHLQLSISASTGLMKTLKLKEDGSEHSVRVEFLWYGTTSNKDKSGAYLFLPDGEAKKYIPSQPPVIRVTKGPVFSEVTTTFTHVTHTVRLYNVKGVDGQAVEISNIVDIRAEFNREIAMRIISD-IGSKDRFFTDLNGFQMQPRRAMAKLPLQANFYPMTSMAYIE----DSLRRLTLLTAQS----LGATSLKSGQL---EVIMDRRLNQDDNRGMGQGVLDNKITANLFRLVLEP----RNPTQENTTPLSYPSLRNHISYMYLNHPLMPMATTWDSDMLTLTPYSPLSSSF--PCDIHLVNLRTIQSQVGEGPSDQAALILHRKAFDCNIATSNTGLLCSTTRGKVTLQRALSNKNTHVSSLEPMSLSLMHESSSRAVDQEITLKPMEIHTYRIQL 1086
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Match: man2b1 (mannosidase, alpha, class 2B, member 1 [Source:ZFIN;Acc:ZDB-GENE-050327-52]) HSP 1 Score: 228.409 bits (581), Expect = 1.536e-61 Identity = 250/1043 (23.97%), Postives = 439/1043 (42.09%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYF--------KDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSIC----CQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMN-KQKEWN-VEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEI--VLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAE-------FNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGAR----RSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAE-NKLFSHILKLFKVDGLLSHTIDIE-NIVDIRKESNYEISMVIKTDFVAPSDE-FFVDSNCFQFIRRK-----TFD---KIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVD-----NEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKT---NFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEIPKLTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVK------------------PEDICMNLMDIDTY 3127
PH+H D GW+KTVD+Y+ Q IL+S++ L K+P +FI+ E +F +WW+ S ++ V +L++ +LE V GGW M+DEA+ HYS++I+Q+ G L + + + G + R+ Y K R K++E W+ SE S+ F+ +P+ P C C D P +DP E+ D NV + + +A +Y N++++ +G DF+Y+ W Y+N KL+ Y+N +QK + V + + S Y L K +++P + D F YAD +WTGYFTSRP LK +R+ + L+ VL S + G S RR +++ QHHDAV+GT K HV D+ +L Q + + + + +N+ + + V L S+RF+ N ++N L++P VH+P+ + + S + Q+ P+ + + + N+ + F++ PL F I+ G + + ++ S+ NKY+ K + TTG + + +L ++ +L+ F Y A SR+TSGAY+F P+ + S + + + EV + + S +++L++ S +++E I + + ++ + D S E F+ DSN + ++R+ T+D P+ GN YPM ++I+ D ++ +++ +S GV ++ GS +E+ L R L DD RG+ EPL + + +V +G LL T++ + D P+ Q V +F + PS +V +L LP HL+ + + L Y S S + + + ++ MF + + ++ SL NQ + + P +I +N M+I T+
Sbjct: 26 PHTHDDVGWLKTVDQYYYGGRNYIQHAGVQYILDSVVSELQKDPARRFIYVETAFFHRWWSEQSAKTRNIVTQLVQEGRLEFVNGGWCMSDEASTHYSAVIDQMTLG-------LQHA-----------------SIFAQMGYDGFFFGRLDYQDKGRRMKMKEMEMVWRA---SE---SLKPPTADLFTGVLPNGYNPPAGFCWDQSCSDD---------PVQDDP-ELEDYNVDDLVNKFISISKAQADVYKT-NHIIMTMGSDFQYENAIPW---YKNMDKLIHYVNARQKNGSAVNVLYSTPSCYLQELNLAK-QIWPIKTDDFFPYADDAHDFWTGYFTSRPALKRYERLSNSLLQTCNQLEVLGGSQSRDGPFGKGDSETM------------RRAMAVAQHHDAVSGTEKQHVANDYAKRLGIGWDHCQVLVSNSLAALSGSNVPRVFCENLNISVCPLTEGSKRFSMN--------------VYNPLARPISWSVHLPVNGSS----YSVQDSNGMAVNSQVIPVSKATQNLRRGRGYAKNE--LVFQVQAPPLGFSTYSIILLGRAGA------------------PDEPKRAAPVSMQNKYL-------KATFDPTTGLLSGLTNLETQQSIQLSQNFYWYNASNGNDESRQTSGAYIFRPN-SSTPYTISSKPVVSTLQNSVVQEVRQQFSPWVSQVVRLYEG----SRDLELEWTIGPVPVDDGLGKEVITRLDSSISSAEYFYTDSNGREVLQRRKDYRPTWDLKQTEPVAGNYYPMNSRAFIK----DKGSQLTVVTDRSQGV---SSLNNGS----LEIMLHRRLLYDDYRGVGEPLSEPGEFGDGLVVRGRLLL------------------TLTPPETAADAHRPLAQGMVLQPLLSFQDGTPSAIVEFSALQA--SLPPAVHLLTLS-------QWDKDSVLLRLEHQYESSESKTYSKPVTVNLQKMFSTLKVVGASEMSLGANQWKANMTRLQWNTGNDAHIYTCSNPTPWEITLNPMEIRTF 923
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006368.1 (pep scaffold:Pmarinus_7.0:GL478975:152485:159376:1 gene:ENSPMAG00000005752.1 transcript:ENSPMAT00000006368.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 299.286 bits (765), Expect = 1.173e-92 Identity = 137/269 (50.93%), Postives = 183/269 (68.03%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMR 868
M +Y L F + DGGVW+QGF + Y + ++ L++ VVPHSH DPGW+KT D+Y+ D TQ ILN M+ L+++ F+ AEV +F KWW+ ++ V++L++ QLE VTGGWVMTDEA AHY ++I+Q+ +GH WL L P +GWAIDPFG+S M Y+L+++G+ M+IQRVHY +K+ LA + LEF W+Q WD I CHMMPF+SYDVPHTCGPDP +CCQFDF R+ R CPW P IT +NV R
Sbjct: 96 MLDVYRLLPFDNPDGGVWRQGFDITYDVGAWEQRPLQIIVVPHSHNDPGWLKTFDKYYVDQTQHILNHMVTKLLEDRRRSFVWAEVSFFAKWWDAADSQRRHSVRRLVERGQLEFVTGGWVMTDEANAHYFAIIDQMIEGHQWLHKTLGVRPRSGWAIDPFGHSPTMAYVLRRAGLQAMLIQRVHYAVKRHLAHERSLEFMWRQDWDVGTSTDILCHMMPFYSYDVPHTCGPDPKVCCQFDFKRLPGSRVNCPWKVAPRAITADNVAER 364
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006359.1 (pep scaffold:Pmarinus_7.0:GL478975:144942:162143:1 gene:ENSPMAG00000005729.1 transcript:ENSPMAT00000006359.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 286.96 bits (733), Expect = 8.641e-84 Identity = 208/707 (29.42%), Postives = 330/707 (46.68%), Query Frame = 2
Query: 950 DFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKIK-------------MFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFD-----QIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF-VSFKLNIGPLAFERVRI-LATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLT---------------GYGLPCDYHLINFKTNINEIP--------KLTIHRLKLNC 2941
DFR++T EW Q+ NY +L DY+N E + +FG LSDYF++L ++ P L GD F+YADR+DHYW+GYFTSRPF K LDR L HLRAAE++ SL+ +H + G++ + +++G+RR L+LFQHHDA+ GTS+ VV D+ +L+ A+ Q V A +L G S F +N+ Y NK + T+ R + + N+L R +V + ++ + + GSG + Q++P++ + + + F + F + L R+ L T S ++L + + ++ + + + TG + V L + YG RRS++ SGAYLF+PDGEG E + G L EV H ++L+ + G+ ++++ N+VD+R ++N E+SM + +D V F D N FQ R+ + K+P+Q N YP+ + ++ D+ ++ LL+ Q+ GV ++ G +EV LDR L QDDNRGL + L DN +RLL E +S D ++ ++ L +P V + N P LVG + L+ G +PCD HL+N + + E P L +HR +C
Sbjct: 1 DFRFETAHEWEQQFHNYQQLFDYINSHPELHARAQFGTLSDYFEALGVWEVSGNASISPPPPPPPALPVLGGDFFTYADREDHYWSGYFTSRPFFKHLDRRLEAHLRAAELLFSLA-SWHAS-RRGVTPLLPARECFARLEGARRNLALFQHHDAITGTSRELVVSDYAARLMRALADLQRVLVDATLVLLLAEPGRSAASAPSQPSFFFLEENVVDYDSLPNKA--VIKLTSAPRSLVVHNALEWERVCVVSVRVDSPLANV-LTHDGSG---VLAQVDPLWSSSTGMSARAFQLQFLARVPALGLAVYRLTLDAPPVPTVRSDTTLYLPGGGPVPPRTQPLLPLALLPPPTTQFSVETASVEAGFSGRTGMLRWVRLKAGGEPRLLRLDLLWYGTRRSKDKSGAYLFLPDGEGKPYESAERPVVRVTRGPLVSEVTCVYPHVQHSVRLYNLPGVEGLSLEVSNVVDLRDQNNRELSMRVSSD-VESDGNFQTDLNGFQMQPRRFWKKLPLQANFYPVATMALVQ----DARSRLSLLTAQAGGV---ASLADGQ----LEVMLDRRLIQDDNRGLGQGLKDNRRSLSRFRLLLET----RSPDGTKWDATMAAA------LGFPSLLGHVASAALNHPPFVLVGVEQRLSPLVEPPQLLPSFHVLGAPVPCDLHLLNLR--MMEAPGAGPPGEAALLLHRKGFDC 675
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003432.1 (pep scaffold:Pmarinus_7.0:GL488094:1155:3927:-1 gene:ENSPMAG00000003140.1 transcript:ENSPMAT00000003432.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 207.994 bits (528), Expect = 2.687e-60 Identity = 106/225 (47.11%), Postives = 141/225 (62.67%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDP-GWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDS-ENKYSIN---CHMMP 727
M +YE L F + DGG WKQGF + Y + L+++VVPHSH DP GWIKT + YF + T+ IL++ + L ++ +FI AEV Y KWW Q+ K+LI QLEIVTGGWVM DEA H +M++Q+ +GH WL+ +L P +GWAIDPFG+S YLL+ +GI NM+IQR HY +KK LA + LEF W+Q W + +N CH MP
Sbjct: 90 MMDVYELLPFDNPDGGAWKQGFDITYEDAAWESTPLQIYVVPHSHNDPAGWIKTFEGYFVEQTKRILDNAMVKLAEDSRRRFIWAEVSYLAKWWEGADAAQRATAKRLIDGGQLEIVTGGWVMPDEANVHVWAMLDQMLEGHQWLERHLGVRPRSGWAIDPFGHSPTNAYLLRAAGIQNMLIQRTHYSVKKHLAHERSLEFHWRQSWGEWQPDAGVNLHHCHTMP 314
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: man2b1 (mannosidase, alpha, class 2B, member 1 [Source:ZFIN;Acc:ZDB-GENE-050327-52]) HSP 1 Score: 218.394 bits (555), Expect = 1.085e-58 Identity = 240/946 (25.37%), Postives = 395/946 (41.75%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYF---KDDTQP-----ILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLN--YTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRC---PWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQK--EWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAE--------FNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVV-LKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSR------ETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAE--NKLFSHILKLFKVDGL--LSHTIDIENIVD-IRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKI--------PIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVD-----NEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINF 2884
PH+H D GW+KTVDEY+ K+D Q IL+S++ L + P+ +FI+ E+ + ++WW + + +V+ LI +LEI+ GGW M DEAT HY+ +I+Q+ G ++ + P W IDPFG+S+ L + G + R+ Y K++ KQ+E W+ S+ + F+ + + P P C FD C P +DP + + NV R L + K+A Y N++++ +G DF+Y+ W ++N KL+ Y+N+ + V + + + Y + L K + + D F YAD +WTGYFTSRP LK+ +R N L ++ L +I + G LL E + + QHHDAV+GT K V D+ +L Q + + A L G+ + +I N + ++ V L+N L Q V +P V+ R ++ + K I +F +++ + F+ I PL F R + + F + N + +KN L + +G + VE+ KS L + Y + S+ + SGAY+F P+ + S + HF + + V + + S +++L+ L T+ + D I KE +KTD V FF DSN + + R+ + P+ GN YP+ YI+ D ++ L+ +S G G +I GS E+ L R L DD+RG+ E L + N +V +G LL + + ++ + + + LI P Q + PS+ + Q S LT LP HL+
Sbjct: 36 PHTHDDVGWLKTVDEYYYGEKNDIQHAGVQYILDSVIPALEQNPSRRFIYVEMAFLKRWWKQQGEAMRRRVRALISQGRLEIINGGWCMNDEATTHYNGIIDQMTLGLRFVSDEFGGCARPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKEQRMKDKQMELVWRA------SKSMGPPVADLFTGVLFNGYNPPPGFC--FDQF------CDDEPIQDDP-SLFNYNVDSRTSDFLKEVAKQAKFYRT-NHIIMTMGSDFQYENANLW---FKNLDKLITYVNQLQVNGSKVNLVYSTPTCYLNELNKANL-TWTVKEDDFFPYADGPHQFWTGYFTSRPALKLFERRSNNLL---QVCTQLEVIVGSGAARGPLGRGYSFLLWE-------AMGVAQHHDAVSGTEKQQVAYDYAVRLSLGWDSCQMLVSNA----LSALSGSGKPTEIC----------RYLNISVCPATESASAFTVVLYNPLGQSVTENVRLP--VNGSRYLVQDPSGATMVSKSIIVVVFPVSDATRAVRRTLGTASGELVFQAAIPPLGFARFSVSRAA----------------RRPAEALTGFVARGPRAGGNGAPISIKNEYYTLTFDGISGLLSNVEN--RKSSLSLPVTQNFYWYKSSKGDDDNGQASGAYIFRPNSSEAFPVAKS--AVTHFTVDPLLQEVRQVFSPWCSQVIRLYPGKPYVELEWTLGPIPLADKIGKEVLVRFDTPLKTDGV-----FFTDSNGREILERRRDKRPTWPLNQTEPVAGNYYPVNSRIYIK----DEKMQLTALTDRSQG---GASIRDGS----FELMLHRRLLYDDHRGVDEALNEPGVWGNGLVVRGRHLLVLEAPARSAALHRPLAQ---AEFMAPMPLIGPPVQAW---------PSSTLTQFSGLT-RPLPPSVHLLTL 886
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000437.1 (pep scaffold:Pmarinus_7.0:GL480287:5325:14229:-1 gene:ENSPMAG00000000390.1 transcript:ENSPMAT00000000437.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 164.466 bits (415), Expect = 5.401e-43 Identity = 126/472 (26.69%), Postives = 220/472 (46.61%), Query Frame = 2
Query: 1598 ERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIF-QLAEFNNNQHFVSFKLNIGPLAF----------ERVRILATGISDTYCSSVHIHLYNIKNSMNFKKN--FQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQ---LKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKT-------NINEIPKLTIHRLKLNCY 2944
R V ++N+L+Q R +V + V T+R ++ + + + QI P++ A+ + + +SF + PLA RV +LA + L+ + ++ V + + + N+ L G+++ V + + + + YG R +R+ SGAYLF+PDG+ E + + EG L+ EV + +H ++L+ + G+ ++++ N+VDI E N+E+ MV+ TD D F+ D N FQ RR+ + K+P+Q NVY MT A+ ++ D R++ LLS Q+ GV G ++VFLDR L QDDNRGL + + DN+ +RLL E + + G ++ + + L +P + + S + + Q + LT LPCD +L+N +T +E L +HR +C+
Sbjct: 23 PRPVVVYNTLAQERVCVVCV--HVSTQRARVRHLD--GRAVLAQIGPVWTAAADMVPDTYQLSFLARLPPLALVTFELWEASDPRVTVLA-----------NTTLFGVTPGHGPQRGGLLGVDVRAAPPPSGLSIHNTHATLRFGGPKGFLQGVRLCGATQEQAVQVDLAWYGTRGARDNSGAYLFLPDGDAKPYETEVEPVVRLAEGPLFSEVTSYLPHVTHTVRLYNLPGVEGLSLEVTNVVDIHSEINHELVMVLTTDLQN-QDIFYTDLNGFQMQRRRFWQKLPLQANVYQMTSAAVLQ----DPERRLSLLSAQALGV-------AGMRPGELQVFLDRRLMQDDNRGLGQGIKDNKPTLSRFRLLPERRSRHDSVPGAVPGTGGSLSLLGHVTSDVLNHPALLLLGEPTPQGS--AAPLAQLTPLT-TPLPCDLYLLNLRTLQATEGGGPSEDIALILHRRGYDCW 464
BLAST of Alpha-mannosidase vs. Ensembl Nematostella
Match: EDO40866 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S628]) HSP 1 Score: 593.193 bits (1528), Expect = 0.000e+0 Identity = 349/984 (35.47%), Postives = 534/984 (54.27%), Query Frame = 2
Query: 272 MLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNL--NYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLA-EFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLY-----NIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNK--EFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNI---NEIPK----LTIHRLKLNC--YAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSG--NQVIGDKVKPEDICMNLMDIDTYAV 3133
M+DFL + +MKFI AE+ YF WW ++K Q IK+ Q+E+VTGGWVM DEA H+ SM++QL +GH W+KN+L + P +GWAIDPFG++ MPYLL++ G ++M+IQR HY +KK LA LEF W+Q WD + I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW PV IT++NV RA MLLDQY+KKA LY N VL+PLGDDFRY + E + QY NY K+ +Y+N E + + +FG L DYF ++ + ++ F SLSGD ++YADR DHYW+GY+TSRP+ K LDR++ H R AE++ L+ H+ K T + L + + +RR + LFQHHDA+ GT+K VVVD+ N+L +++ Q V Q +L N +Q + I + ++ N + I ++ R VY++NSL + R+ +V + + + + S ++ Q N ++ + ++ ++ + F ++ PL ++ +SD + + Y + S +F Q L + N L +STTG ++ + S+ +++ F YG + + SGAYLF+PDG + T+ G++ EV H+++L++ DG H++DI+N VD+R +N E M ++TD + EF+ D N F + RR+T DK+PIQ N YPM +++E DS ++ LLS Q NGV G +EV +DR L QDDNRGL + + DN+ +RL+ E + Q + NK + ++ ++ L L++P K + ++ S G L + LPCD L+ ++ + E P + +HR C + I + S L+ + +F D+ + + SLS +Q + D P I ++ M++ +Y V
Sbjct: 1 MVDFLAEHKDMKFIWAEISYFSMWWKDADPHRKKQALSQIKSGQMELVTGGWVMNDEANPHFYSMLDQLIEGHQWIKNHLGPDIKPVSGWAIDPFGHTSTMPYLLRRIGFHSMLIQRTHYQVKKHLARETNLEFMWRQIWDHGSSTDILCHMMPFYSYDVPHTCGPDPKICCQFDFRRLPGGRVTCPWRIPPVPITEQNVAERATMLLDQYKKKAKLYKT-NVVLIPLGDDFRYDLKMEPAAQYDNYQKIFNYINSHPEMHAQAQFGTLKDYFQAIYQKTGTNPGERPPNFVSLSGDFYTYADRDDHYWSGYYTSRPYYKNLDRVMEAHHRGAEMLFYLA---HSHAKRAGVTHYPADKLSQLLTNARRNMGLFQHHDAITGTAKDFVVVDYGNRLHRSLQDMQNVMQECMQFLLSPN--KAQEPKHILKPGEDRP-AQDANPIKEVIILSSSPRSVYVYNSLPEQREQVVSLFVSDPL----VTVRDSSGDVVISQTNLVWDARNKISSVKYELLFVASVPPLGVAVFKVKLGSVSDAHNRPSRVTAYTRDTLDKPTSEHFNIELQAPGSEVL-----TMNNHLISAEFDSTTGMLKSITTKADGSRVNVDLEFMTYGTKSYGDRSGAYLFLPDGPAKPHTVPAHTTVFFTSGKVMQEVRVVLPNVVHVVRLYRTDGPEGHSLDIQNTVDVRSMNNKEFVMRLRTDIQNKNREFYSDLNGFSYQRRRTLDKLPIQANFYPMPTMAFLE----DSNHRLSLLSAQPNGV-------AGLQTGMLEVVMDRRLLQDDNRGLGQGVTDNKETPSHFRLVLERF-QTPTQQNKRPDLAFPSLLTHLLSQHLLHPQFIFLAKPDAEDTATSLSPGFTGLQS--PLPCDVSLLMLRSVLEGEEEKPSGEALMVLHRRGYECGLSSSCIKDASGGKLK-----LGELFKDLPMSQATRTSLSMLYDQGVQDPTTP--ISLDPMELHSYRV 947
BLAST of Alpha-mannosidase vs. Ensembl Nematostella
Match: EDO37584 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFA1]) HSP 1 Score: 251.521 bits (641), Expect = 2.188e-69 Identity = 257/1006 (25.55%), Postives = 443/1006 (44.04%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYF--------KDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNL--NYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRC---PWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPI---------FQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSR-ETSGAYLFIPDGEGSI-IEFDSLNTIVHFEGELYDEVVAE-NKLFSHILKLFKVDGLLSHTIDIENIV-DIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQF-IRRKTFDKI-------PIQGNVYPMTCASYIESKIF--DSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRL-----LFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYG--LPCDYHLINFKTNINEIPKLTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDK 3079
PH+H D GW+KTVDEYF Q IL+S++ L ++PN +FI+ E+ +F++WW+ + ++ VKKL+ K+LE + GGW M DEA HY+++I+Q+ G +++ + P W IDPFG+S L + + R+ Y K +++E W+ N + Y+ P P C FD C P +DP + DENVK R E + ++ Y + NN+++ +G DF Y+ W Y+N KL+ ++N+ V + + Y ++L + + + D F YAD YWTGYFTSRP LK R+ N L+A + + L+ S + LL RR L++ QHHDAV+GTSK HV D+ +L Q + + + + GN+ +F NL N ++ + + V +N +++ + +P+ + + + IK Q+ PI Q +N+++ + FK+ + PL F +S ++ + M + K+F V + V++N KL + TG + + DL S+ +++ F Y A + + SGAY+F P+ + + T ++G L EV + S +++L+ + I D+ +E IK++ V F+ D+N + +R + F P+ GN YP + S+IF DS R++ LL+ +S G G ++ GS +E+ L R L DD RG+ EPL ++ + KG + + + ++E GE Q+M + I Q ++V L SL TG LP + H++ +T+ + + RL+ + ++ K + ++ +F D+ + V + +L+ NQ++ DK
Sbjct: 46 PHTHDDVGWLKTVDEYFYGANNSIQHAGVQYILDSVIPALNEDPNKRFIYVEIAFFKRWWDQQNVEMQEIVKKLVLQKRLEFINGGWCMNDEAATHYNAIIDQMTVGLKFIEETFGSDARPRIAWHIDPFGHSNEQASLFAQMSFDGFFFGRIDYDDKTLRLKQQRMEMVWRG--SKSGNLGKNSDIFTGVLYN---GYNPPPGFC--FDQF------CSDQPIQDDP-RLYDENVKQRVEEFIKLACEQGSQYKS-NNIMMTMGSDFMYENANLW---YKNLDKLIAHVNQDSR--VRAFYSTPTTYLEALHAANL-TWGLKTDDFFPYADCPHCYWTGYFTSRPALKRYSRLNNNLLQACKQLEVLN-------GPAQSGSPSSDLL-------RRALAVAQHHDAVSGTSKQHVADDYAKRLAIGAADCQALMSNVIGKKSIKSKGNA---PPVFSSCNL------LNVSSCPSTEDSKSFVVNAYNPIARDITSYIRVPVN-----LPMSVYNPQGAAIKSQLLPISQETMTLRRMQKLSASNSKYELIFKVKLPPLGF---------------ASYFVNTSKTSSKM-YGKSFAV-------DPSTVIQNEFIKLEFSRDTGRLTSMTDLVSEVTTQVDQQFLWYNASVDQGQPSGAYIFRPNTSSTTPVNAGGKATFTVYQGPLVQEVRQVFSPYVSQVVRLYYGQKHAEFEYTVGPIPDDLGREVITRFDSDIKSNKV-----FYTDANGREMQLRTRDFRPTWKLNNTEPVAGNYYP------VNSRIFVKDSNRQLTLLTDRSLG---GSSLKDGS----VELMLHRRLLVDDKRGVDEPLNESGISGKGLIVRGKVNVVLAPPATSAATHRELGE------QMMLEPIVSFAQN------PSTVEKWLAKYNSLYTGVARQLPSNVHMLTLETS----NQYALIRLEHQ----FEADEDSKLSMPVNVSLQGLFTDLEVSKVEELNLAANQLLKDK 941
BLAST of Alpha-mannosidase vs. Ensembl Nematostella
Match: EDO33329 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SSJ0]) HSP 1 Score: 50.447 bits (119), Expect = 4.836e-6 Identity = 33/144 (22.92%), Postives = 56/144 (38.89%), Query Frame = 2
Query: 194 HSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHY 625
+ H+D W+ E + + + + + K P+ KF ++ E W +++KK + N Q V WV D S I Q G + K W D FGYS +P ++ GI + Q++ +
Sbjct: 261 NCHIDCAWLWPAAETVRKCGRSFATA-VQLMKKYPDFKFACSQAQQLE-WVKIHYPGLYEEIKKFVANGQFIPVGATWVEMDGNIPSGESFIRQFVVGQQFFKEEFGMMCKEFWLPDTFGYSAQLPQIITGCGIKFFLTQKLSW 402
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: man2a2 (mannosidase alpha class 2A member 2 [Source:NCBI gene;Acc:101158104]) HSP 1 Score: 686.797 bits (1771), Expect = 0.000e+0 Identity = 392/981 (39.96%), Postives = 562/981 (57.29%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKK-------DKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSL-IYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQI--IFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF-VSFKLNIGPLAFERVRILATGISD-TYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEF-TVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEIPKLT--------IHRLKLNC 2941
M +Y L F + DGGVWKQGF + Y + L+VFV+PHSH DPGWIKT D+YF D TQ ILN+M+ L ++P KFI +E+ YF KWW T +++ ++KLI QLEIVTGGWVMTDEA AHY +MI+QL +GH WL+ N+ TP +GWA+DPFG+S MPYLLKKS + +M+IQR+HY IKK +S++ LEF W+Q WD+ + I CHMMPF+SYDVPHTCGPDP ICCQFDF R+ R CPW P I + NV RA++LLDQYRKK+ LY +LVPLGDDFRY EW QY NY KL DYMN E +V+ +FG L+DYF +L K + FP LSGD F+YADR+DHYWTGY+TSRPF K LDR++ +HLR AEI+ SL++ ++ G V + SLL + +RR + LFQHHDA+ GT+K +VV+D+ N+LL ++ + V AA ++ N +F Q + D+ ++ + + I + G RY+ +FN + Q R LV + + + ++++ Q + Q++ + A + + F +F + PL + + S T S + L + + V S+ + + + L L + +TG +E ++ + K+ I F YG S++ SGAYLF+PDG+ + EG L+ EVVA + F +++ V G+ ++DI +VDIR +SN E+SM + TD + D F+ D N FQ R+ + K+P+QGN YP++ +YI+ DS ++ L + Q+ GV T F+ + EV +DR L QDDNRGL + L DN+ +RLL E G + F ++ S+ L + V + V P L L++ + PCD+HL+N ++ N+ LT +HRL L+C
Sbjct: 131 MLDVYSLLKFDNPDGGVWKQGFDITYEANEWDNEPLQVFVIPHSHNDPGWIKTFDKYFTDQTQHILNNMVVKLAEDPRRKFIWSEISYFSKWWETAEPQKQEAMRKLILEGQLEIVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNIGVTPRSGWAVDPFGHSATMPYLLKKSNLTSMLIQRIHYSIKKHFSSTRNLEFMWRQAWDTGSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPKPIVEANVAERAQLLLDQYRKKSKLY-RSKVLLVPLGDDFRYDKSLEWDQQYINYQKLFDYMNSHPELHVQAQFGTLTDYFSALYKTTGAAAGSRPADFPVLSGDFFAYADREDHYWTGYYTSRPFYKSLDRVIESHLRGAEILYSLAVATARHEGMEGRYPVTDYSLLVD----ARRAVGLFQHHDAITGTAKENVVIDYGNKLLRSLIGLKRVIINAAHFLVMKNRDFYRFYQTEAFLETDDRRATQDALPQRTLIELDPAGPRYLVVFNPIEQERLCLVKVLVNT----VRVRVLTEDGQTLPVQLSAQWGSATQMSAEVFQATFMARLPPLGLAVFHLYDSADSPMTLRSDTLLRLSSRSVTARASDPLPVHSQLADPQSFYISSQFL-TLGFSGSTGLLESIKRKDDSKEVKVQIQFMVYGTSPSKDKSGAYLFLPDGKPKPYNQKEPPVVRVVEGPLFSEVVAHYQHFEQTIRIHNVPGVDGLSVDISTMVDIRDQSNKELSMRLSTD-IKSDDIFYTDLNGFQIQPRRFYQKLPLQGNFYPISSQAYIQ----DSQHRLTLHTAQALGV----TSFESGQL---EVIMDRRLMQDDNRGLGQGLKDNKRTENRFRLLLERRSSGNKGTDSSTNSFPSIVSHMTSAILNHEVLPLPVVPKRRGIPP--LKTFAPLMSRF--PCDFHLLNLRSIQNKQDGLTPSPHTALLLHRLALDC 1085
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: ENSORLT00000044084.1 (alpha-mannosidase 2 [Source:NCBI gene;Acc:101174073]) HSP 1 Score: 652.899 bits (1683), Expect = 0.000e+0 Identity = 374/1023 (36.56%), Postives = 579/1023 (56.60%), Query Frame = 2
Query: 77 LYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFR--CPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKIKM---FPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQ--IIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHF-VSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSS-ENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHF-EGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGY-GLPCDYHLINFKTNINE----IP----KLTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKP 3088
+Y+ L F + DGG WKQGF++ Y + + L++F+VPHSH DPGW+KT D Y++D T+ ILN+ML L ++ K I AE+ YF KWWN I + ++ VK+L++ QLE+VTGGWVM DEA +HY ++++QL +GH WL+ +L P++GWAIDPFG+S M YLLK +G+ NMVIQR+HY +KK A K LEF W+Q WDS + I CHMMPF+SYDVPHTCGP+P++CCQFDF R+ R CPW P IT++NVK RA +LLDQYR+K+ L+ +LVPLGDDFRY EW Q+ NY KL DY ++ E +++ +FG LSDYF +L + P+LSGD F+YADR DHYW+GY+TSRPF K LDR L + LRA EI+ SL+L ++ L F +++ RR L LFQHHD + GT + VVVD+ +L +AI + V +A +L + DQ D++ S + + + + ++ R + ++N Q R ++ + + R+ + Q + QI+ ++ + ++Q F +SF + PL+ + T S+ IH + + S+ ++FQ+S E + ++ L N ++ + TG ++ + L S ++ + F YG +R+ SGAYLF+P G+G + S +V G ++ ++ + + +H ++LF ++G +I+I N+VDIR E+N E+ M +++D VA S+ F+ D N FQ +R+T K+P+Q N YPM+ +S+++ DS ++ LLS QS + ++ G +EV LDR L QDDNRGL + + DN++ Y LL ED + ++ ++ ++ L +P MF +++ L + L + LPCD HL+N +T E P L +HR C + C + + + +F + + + + SG ++ D +P
Sbjct: 119 VYDLLPFDNPDGGAWKQGFQITYQGNEWAEQPLELFLVPHSHNDPGWLKTFDGYYQDQTRHILNNMLLKLGEDSRRKMIWAEISYFSKWWNEIDEQKRMMVKRLVEAGQLEMVTGGWVMADEANSHYFALLDQLMEGHQWLQRHLGLKPSSGWAIDPFGHSPSMTYLLKGAGLRNMVIQRIHYAVKKHFAQKKTLEFLWRQSWDSSHSSDITCHMMPFYSYDVPHTCGPNPAVCCQFDFYRLPGGRTSCPWRIPPQPITEKNVKERAHVLLDQYRQKSRLF-RIPVLLVPLGDDFRYVESGEWDAQFNNYQKLFDYFDQHPELHIKARFGTLSDYFSALHRRLSATETSLPTLSGDFFTYADRDDHYWSGYYTSRPFYKRLDRALESTLRATEILFSLTLAEMRRFHGDLVVGFPAREHFQRLVEGRRNLGLFQHHDGITGTGRDPVVVDYGTRLFHAILHLRQVQQSSAHWLLLLDKNQYHHDQSKPFLQTDDVISAQDALPQKTPL-VLSDEPRVLIVYNPTEQRRSSVISVVVSSPDARV---VDSETAQPMPVQISAVWVEPQQVSSQAFQLSFVAELPPLSLTVYHVTKAPAGSTPRSTYVIHRHGNRPSIA-SQHFQLSRLEAAEAQTHLSLSNKHLQIWSSPETGLLQKLR-LSSGLVRRVQVKFLWYGTTTNRDKSGAYLFLP-GQGGAQPYSSEPPLVRVSRGPIFSDITSCFQHVTHTVRLFHLEGHSGKSIEISNMVDIRAETNRELVMRLESD-VASSNRFYTDLNGFQMQQRRTLKKLPLQANFYPMSSSSFLQ----DSLSRLTLLSAQS---QAAASLQSGE----LEVILDRRLQQDDNRGLGQGVTDNKLTGSLYHLLLEDRRAVQEVGGATIDHLSLLAHLESLSLCHPPIIMFAQSDI------QLPKLRPFLPLHSSLPCDVHLLNLRTLEAEEETGAPSQEVALLLHRKGFECSSAPEPPPQCTWSAHEEVNLDDLFSPLQFRSIRR---SGLTLLRDHDEP 1112
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: man2b1 (mannosidase alpha class 2B member 1 [Source:NCBI gene;Acc:101168422]) HSP 1 Score: 246.899 bits (629), Expect = 1.651e-67 Identity = 233/864 (26.97%), Postives = 389/864 (45.02%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYFKDD--------TQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSIC----CQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQ--KEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHFVS----FKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGA-----RRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLF-----SHILKLFKVDGLLSHTIDIENIV-------DIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFI-RRKTFDKI-------PIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEV 2647
PH+H D GW+KTVD+YF D Q IL+S++D L+K P+ +FI+ E +F +WW S + + VK+L+ +LE V GGW M+DEA HYS++I+Q+ G +L P W IDPFG+++ L + G + R+ Y + S K+ E W+ S+ M F+ +P+ P C C IR +DP E+ D NV + L K+A +Y N++++ +G DF+Y+ W Y+N KL+ ++N Q K V + + S Y L + + +P D F YAD ++WTGYFTSRP LK +RI ++L+ + L K +G +Q+L R+ +++ QHHDAV+GT+K HV D+ +L + + Q + + + + ++ D + V L S++F+ V ++N L++P V +P+ I GN + ++ E N+ + F++ PL + TY S +++ + + + + S+ NK++ +++ + TG I + +L +K L F Y A S++ SGAY+F P+ S + F ++ + E + VV E + + S +++L+ S +++E V + KE + IKT S+ F+ DSN + + RRK F PI GN YP+ ++I+ D ++ +++ +S G G +I GS +E+ L R L DD RG+ EPL NEV
Sbjct: 61 PHTHDDVGWLKTVDQYFYGDRNDIQHAGVQYILDSVVDQLLKNPDRRFIYVETAFFYRWWKQQSSSMQQTVKQLVNEGRLEFVNGGWCMSDEAATHYSAVIDQMTLGLRFLNETFGACGRPRVAWHIDPFGHAREHASLFSQMGYDGFFFGRLDYQDRDSRRSKKEQELLWRA------SDSLPAPMADLFTGILPNGYNPPTGFCWDQLCNDPPIR---------DDP-ELEDYNVDDVVQRFLQIANKQAEVYKT-NHIIMTMGSDFQYENANLW---YKNLDKLLLHVNSQQAKGSKVNVLYSTPSCYLQELHRAN-RTWPLKMDDFFPYADDAHNFWTGYFTSRPALKRYERISNSNLQTCNQLEVLGGAASRKGPFGEGD--SQTL--------RKAMAVAQHHDAVSGTAKQHVTNDYARKLADGWQRCQVLVSNSLASLSGSSAPRIYCDLLNVSVCPLTESSKKFS--------------VTVYNPLARPVVWPVRLPVYGSAYLIKDP---KGNSVDSQVLSVSKATREVRRNRGHAANELVFQVQAPPLGYT-----------TYSVS------SLQGRPSSAASPKRGAPTSIQNKFL-------QVNFDPDTGLISGLSNLETKQSINLTQNFYWYNASDGKNSESKQPSGAYIFRPN---STVPF-VISRVAQTE-TIQTSVVQEVRQWFSPWVSQVVRLYAD----SRALELEWTVGPLPVSDGLGKEVITRLDSSIKT-----SEMFYTDSNGREILQRRKDFRPTWQLKQSEPIAGNYYPINTRAFIK----DDVDQLTVVTDRSQG---GGSIQNGS----LEIMLHRRLLYDDYRGVGEPL--NEV 825
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: man2b2 (mannosidase alpha class 2B member 2 [Source:NCBI gene;Acc:101167078]) HSP 1 Score: 204.142 bits (518), Expect = 2.902e-53 Identity = 213/851 (25.03%), Postives = 361/851 (42.42%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKN-QKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDP---SICCQFDFIRIIYFRCP-----WGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMN-KQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNF--IHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIA--FKKY---GARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEV-----VAENK-----LFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRR--KTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRIL--NQDDNRGLFEPLVDNEVV 2650
PHSH+D GW+ T+ E + +S+ + L K +FI E +F WW+T++ + QK QV++L+K+ +LE + GG VM DEA I Q+ +GH +L P W +DPFG S P L +G N +I R+ Y +K + +K+L+F W+ + I H M FSY C P S F + + F P + N + +T E + A+ +++ +++A + N+VL P G D ++ S+Q+RN LM Y+N K KE+ V +++ LS YF ++ + + S D Y+ WTG++ SR LK L R + L AAEI+ + ++ + V L +K+ R +S QHHD + GT V + Q ++Q +G + +F L Y + NF + E++V ++N L+ +V+I + + G + Q + QI Q + +N + + + +G L + I +G S H Y K + ++ + + L V+ N KL + T + + LYS K ++ + F +Y G + S Y+F + ++ + ++ + G++ E+ EN + ++ F GL H + V + N E+ + T + + + D N FQ ++R K F + N +PM +YI+ D + LLS +++GV +EV L R L NQ N G L D+ VV
Sbjct: 102 PHSHMDVGWVYTIQESMHAYAANVYSSVTEELSKVKERRFIAVEQEFFRLWWDTVASDLQKKQVRQLVKDGRLEFIIGGQVMHDEAVTDLDDQILQMTEGHGFLYQTFGVRPQFSWHVDPFGASATTPVLFALAGFNAHLISRIDYDLKDAMQKTKKLQFVWRGSPSLAAQQEIFTHTMDQFSY-----CTPSHVPFSNSSGFYWNGVALFPDPPKDGVYPNMSLPVTKETIDAYAKTMVENIKQRAAWFRT-NHVLWPWGCDKQFYNS---SVQFRNMDPLMKYINQKSKEFGVTVQYATLSQYFQAVHQSNLTWDVRGSQDFLPYSTEPYQAWTGFYASRNVLKGLARRASSQLHAAEILFTRYRVH-----FPDGPVAKDWAL-DKLRALRWAVSEVQHHDGITGTESPKVADMY------------------VQHLMQGMMGVQELQAALF---LLPHYLDNPAVENFHGAGVDQALEQHVIIYNPLAWNITTVVNITVTL----AGAAVYDDEGQPVSAQI----QHSAQSNASYDLFVVVQLGGLQHRKYLIRFSGKSG--------HTYEAKAVVFERRRVKDWTRTGRLRLPVL--NRCYKLMFDQETNLLHSITHLYSPKKQRVMMTQDFWEYHANGDVNAGPISDNYIFSANAS-AVRAYQAVEMQI-IPGQIVTEIRQYFYRGENDSDYAYSITTLVPEFSGAGLPCHRLQQTYSVGPL-QLNTEVVLRTSTS-LKNNQSLYTDDNGFQMMKRTYKKFQNNTLARNYFPMVRTAYIK----DDRSGLVLLSDRAHGV-------SSQANGELEVMLHRRLWNNQPWNLGYNLTLNDSSVV 883
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Match: man2b2 (mannosidase alpha class 2B member 2 [Source:NCBI gene;Acc:101167078]) HSP 1 Score: 73.9442 bits (180), Expect = 4.816e-14 Identity = 38/108 (35.19%), Postives = 58/108 (53.70%), Query Frame = 2
Query: 191 PHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKN-QKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNL 511
PHSH+D GW+ T+ E + +S+ + L K +FI E +F WW+T++ + QK QV++L+K+ +LE + GG VM DEA I Q+ L L
Sbjct: 32 PHSHMDVGWVYTIQESMHAYAANVYSSVTEELSKVKERRFIAVEQEFFRLWWDTVASDLQKKQVRQLVKDGRLEFIIGGQVMHDEAVTDLDDQILQMTGDPVMLHRRL 139
BLAST of Alpha-mannosidase vs. Planmine SMEST
Match: SMESG000018139.1 (SMESG000018139.1) HSP 1 Score: 2101.25 bits (5443), Expect = 0.000e+0 Identity = 1025/1026 (99.90%), Postives = 1025/1026 (99.90%), Query Frame = 2
Query: 68 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDXXXXXXXXXXXPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNKEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEIPKLTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHFDN 3145
MTKLYESLDFTDNDGGVWKQGFKVEYAMEDVKKVKLKVFVVPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDN EFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEIPKLTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHFDN
Sbjct: 120 MTKLYESLDFTDNDGGVWKQGFKVEYAMEDVKKVKLKVFVVPHSHLDPGWIKTVDEYFKDDTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYTPTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFNNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSHILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDNNEFGEFTVSSYQLMNDLIYPVHQMFVKTNFTNSVPSNLVGQKSLLTGYGLPCDYHLINFKTNINEIPKLTIHRLKLNCYAGYISEGSCKFLRKKSPLMKSMFDDVSIKYVNKFSLSGNQVIGDKVKPEDICMNLMDIDTYAVHFDN 1145
BLAST of Alpha-mannosidase vs. Planmine SMEST
Match: SMESG000045085.1 (SMESG000045085.1) HSP 1 Score: 205.297 bits (521), Expect = 6.266e-54 Identity = 223/879 (25.37%), Postives = 391/879 (44.48%), Query Frame = 2
Query: 194 HSHLDPGWIKTVDEYF---KDDTQP-----ILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSIC----CQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSL----KKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEF-------NNNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNFQVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSR-ETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAENKLFSH----ILKLFKVDGLLSHTIDIENIVDIRKESNYEISMVIKTDFVAPSDEFFVDSNCFQFIRRKTFDKI--------PIQGNVYPMTCASYIESKIFDSTRK--VFLLSKQSNGVRVGKTIFKGSTMN-FIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGDN 2707
H+H D GW+KTVD+Y+ +D+ Q ILN+++ L + PN KF + E+ YF +WW +++VK L+ +L+ + GGW M DEAT HY S+I+Q++ G +L P W IDPFG+S + G + + R+ Y K++ ++K +EF K S I+ ++ YD C P P C C D P +DP + D NV+ R + D K++ Y N++LVP+G DF+++ + N KL+ ++N+ ++ ++ + + + Y ++ KK KIK + D F YA + YWTGYFTSR LK + N + + + LS N++ L++KI + + QHHDAV+GT K HV D+ +L + + + V + +++ N +D ++ ++ N+ S+ + ++ + T V ++N L R IP+ V KI S L+ Q+ PI + + + ++F+ + L + + I+ + S+++ S I N K+ +V+ N K L + G++ + +L S + + Y + + + SGAY+F P S + + +G+L EV +++FS + +L+ +L + I I EI + +TD + + FF DSN Q I R+ + P+ GN YP+ ++ +++ + RK + + + ++ GV GS N IE+ + R DDN G+ EPL + G + + W + DN
Sbjct: 45 HTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQDSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQK---GSFLPTKIHNYLFTNVLYD--SYCTP-PGFCFDDKCSDD---------PIMDDPT-LHDYNVQKRVDDFSDYVIKQSKAYQT-NHLLVPMGCDFQFQNANH---NFVNLDKLIFHVNRLRK-DINVFYSTPACYTLAINKIGKKLKIK-----NDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQ-------------NRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVN--YDFVLCNLLNI-SFCAISDNISYTKLLT-----VLIYNPLGVTRMEWHRIPVNV-LHGDEYKISHSNGSLVPSQLVPITNCTKHLPERPKESLANYELTFQSVLPALGYASLTIIRSKKSNSFTKSSTIKNINSKDK-------------------IVIGN--KYLKLTYDNGFLVSLSNLQSNVSVNITQDMRYYFSYQGNGQKSGAYIFRPTTNES-MPLTKAPKLTIIKGDLVTEV---HQVFSEWGMIVTRLYNDSNILETEWTVGPI-PINDSKGKEIVLQYQTD-IDSDNCFFTDSNGRQIITRQINKRTDYNFTQTEPVAGNYYPVNSHVFL-AELNNKERKKSLVIYTDRAGGV--------GSYKNGMIEIMVHRRTLFDDNFGVGEPLNETGADGNGLIVRGKQWIKFDYIDN 839
BLAST of Alpha-mannosidase vs. Planmine SMEST
Match: SMESG000045072.1 (SMESG000045072.1) HSP 1 Score: 180.644 bits (457), Expect = 3.387e-46 Identity = 152/534 (28.46%), Postives = 254/534 (47.57%), Query Frame = 2
Query: 194 HSHLDPGWIKTVDEYF---KDDTQP-----ILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSIC----CQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMNKQKEWNVEIKFGILSDYFDSL----KKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGLSTVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVDNLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPI 1741
H+H D GW+KTVD+Y+ +D+ Q ILN+++ L + PN KF + E+ YF +WW +++VK L+ +L+ + GGW M DEAT HY S+I+Q++ G +L P W IDPFG+S + G + + R+ Y K++ ++K +EF K S I+ ++ YD C P P C C D P +DP + D NV+ R + D K++ Y N++LVP+G DF+++ + N KL+ ++N+ ++ ++ + + + Y ++ KK KIK + D F YA + YWTGYFTSR LK + N + + + LS N++ L++KI + + QHHDAV+GT K HV D+ +L + + + V + +++ N +D ++ ++ N+ S+ + ++ + T V ++N L R IP+ V KI S L+ Q+ PI
Sbjct: 45 HTHDDVGWLKTVDQYYYGYRDNIQGAGVQYILNTVISALWENPNRKFSYVEIAYFYRWWQQQGSTVRNRVKVLVNEGRLQFLLGGWCMNDEATTHYVSIIDQMSLGLDFLNKTFGECGRPLVSWQIDPFGHSIEQANIFASMGFDGLFFWRLDYRDKEQRIATKNMEFIQK---GSFLPTKIHNYLFTNVLYD--SYCTP-PGFCFDDKCSDD---------PIMDDPT-LHDYNVQKRVDDFADYVIKQSKAYQT-NHLLVPMGCDFQFQNANH---NFVNLDKLIFHVNRLRK-DINVFYSTPACYTLAINKIGKKLKIK-----NDDFFPYASGPNSYWTGYFTSRSALKGFVQYSNNVFQVCKQLHVLSQQ-------------NRTDLNKKIISMAMKMGVAQHHDAVSGTEKQHVAFDYAQRLSDGLSDCESVINSSLSKLISKETVN--YDFVLCNLLNI-SFCAISDNISYTKLLT-----VLIYNPLGVTRMEWHRIPVNV-LHGDEYKISHSNGSLVPSQLVPI 530
BLAST of Alpha-mannosidase vs. Planmine SMEST
Match: SMESG000032135.1 (SMESG000032135.1) HSP 1 Score: 156.377 bits (394), Expect = 1.431e-38 Identity = 191/862 (22.16%), Postives = 369/862 (42.81%), Query Frame = 2
Query: 197 SHLDPGWIKTVDEYFKD--------DTQPILNSMLDFLIKEPNMKFIHAEVVYFEKWWNTISKNQKDQVKKLIKNKQLEIVTGGWVMTDEATAHYSSMINQLADGHSWLKNNLNYT--PTTGWAIDPFGYSQFMPYLLKKSGINNMVIQRVHYIIKKRLASSKQLEFRWKQFWDSENKYSINCHMMPFFSYDVPHTCGPDPSICCQFDFIRIIYFRCPWGNDPVEITDENVKMRAEMLLDQYRKKALLYDNGNNVLVPLGDDFRYKTEKEWSIQYRNYIKLMDYMN-KQKEWNVEIKFGILSDYFDSLKKDKIKMFPSLSGDMFSYADRQDHYWTGYFTSRPFLKILDRILMNHLRAAEIVLSLSLIYHNKYKYGL--STVFNQSLLHEKIDGSRRTLSLFQHHDAVAGTSKAHVVVDFKNQLLNAIKMSQFVFTYAAQRILQNNIGNSQFDQIIFDVD----NLKSYSERFNKNNFIHIQTNGERYVYLFNSLSQPRQLLVHIPIEVDTERIGIKIMGSGNQLIKCQINPIFQLAEFN-NNQHFVSFKLNIGPLAFERVRILATGISDTYCSSVHIHLYNIKNSMNFKKNF-----QVSSENSLLNKYVVLKNSLKKLHINSTTGYIELVEDLYSKSKYKLNIAFKKYGARRSRETSGAYLFIPDGEGSIIEFDSLNTIVHFEGELYDEVVAE-NKLFSHILKLFKVDGLLSHTIDIENIV-DIRKESNYEISMVIKTDF-VAPSDEFFVDSNCFQFIRRKTFDKIPIQGNVYPMTCASYIESKIFDSTRKVFLLSKQSNGVRVGKTIFKGSTMNFIEVFLDRILNQDDNRGLFEPLVDNEVVSKGYRLLFEDWKQLKSGD 2704
SHL+ W+K + E FK + + + NS+ L +FI E+ +F++W+ + QK V+ Q + V+GG V+ DEAT HYSS+INQ++ G ++K N P W I+P+G+S+ + +LKK + + V SK F W +++ N + S P C G+ N+K +E ++ K+ L +N ++L+P+G DF ++ E ++N+ K++D +N KQK + V + + Y +++ + +K D F + +W G+++SRP LK++ R+ ++++ +++ +LS N+ K L V+ +L+ + QH+D + G + +L +AIKM + + ++ N + + FD + S ++ +IQ N + +FN L P + +++P+ +D + ++ N L+ I PI ++ N N Q K NI + + ++ TG Y I + +KNF + S++ +L + + NS+ + +N T + + + K L + K Y + + +F+ + + + S T +G L E+ + ++LF+ ++IE I+ I + SN+ V+ + ++ +++FF DSN Q I+R + I+ N YP+T + +++R + +L V VG G T N +E+ ++RI+ D + L + K ++ +W ++ S D
Sbjct: 2 SHLENSWLKELGELFKCTEIHMNKVNIKTLFNSVYLALKINSTRRFIITEISFFQQWYEDLDTTQKATVRIFFDRGQFQFVSGGIVINDEATTHYSSIINQISLGLKFIKVNFGVCARPLVSWQINPYGHSREVANILKKMDFKAIFLGHV---------PSKLSNFDLDFLWQTKDTNDTNFNNTILASIITNGLVAPK--------------MFCFHGH-----CQNNLKSASENFINYVMKRISLQNNKKHILIPIGCDFHFQQALE---TFQNFDKIIDTVNSKQKVFRVF--YSTPACYLEAIS-NSVKTLQIYKSDFFPFDKSMKEFWIGFYSSRPNLKLIIRLAESYIQTCKMITALSDKEFNRRKTKLINDLVYLSNLISKT-----------QHYDYITGNHPGQIAQLKIKELSSAIKMCHDLSAAGVESTMKLKSSNRK-SMLFFDCPYHDFSFCSLTD--------NIQLNKIVNLIVFNPLPYPHTVWIYLPVNLDIHQ-TYEVKDVWNTLLPIDIVPINKMILNNINRQPKSKAKYNI----YFKAQLPETG-------------YTIFSIRRKRKNFWDFNKVLVSKSLILKNNIYISNSIINVSLNLKTNRLIIQKQ---SRKISLFLGIKCYCTNLDVVNASSGVFVSELKDNSQAIHSKPTSYILDGSLVKEIRRRYSNGIGLTIRLFEDQD----NVEIEWIIGGIDENSNFNREYVLTYNSDLSINNQFFTDSNGRQLIKRFLKKGLSIESNFYPITSHVLV-----NNSRNLAMLIHTDRSVAVG-----GKTPNSVELLINRIILSSDKGSFNKQLKEVGANRKILSVIGRNWIEIGSTD 774 The following BLAST results are available for this feature:
BLAST of Alpha-mannosidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Alpha-mannosidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Alpha-mannosidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of Alpha-mannosidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Alpha-mannosidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017604 ID=SMED30017604|Name=Alpha-mannosidase|organism=Schmidtea mediterranea sexual|type=transcript|length=3227bpback to top protein sequence of SMED30017604-orf-1 >SMED30017604-orf-1 ID=SMED30017604-orf-1|Name=SMED30017604-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1027bp MTKLYESLDFTDNDGGVWKQGFKVEYAMEDVKKVKLKVFVVPHSHLDPGWback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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