DDE_Tnp_1_7 domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017568 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Zebrafish
Match: pgbd4 (piggyBac transposable element derived 4 [Source:ZFIN;Acc:ZDB-GENE-091204-417]) HSP 1 Score: 58.5362 bits (140), Expect = 2.382e-8 Identity = 42/172 (24.42%), Postives = 76/172 (44.19%), Query Frame = 3 Query: 816 TVLDFFQMHFTDELTMEITKQTNDYAGLQLANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDW----TNTMPFFVDVFSRMRFLQIQWILHLSLPVPVGAVVIRSD------------KLEIVVNTVQDIC*HKFIQDQPITIDESTIGLKRR 1283 +VL +F++ F+ + +I +N + ++ R KWK ++ A++K + +++ M I +CF W ++P+ + SR++FL I W LHLS P V +D K++ + ++D C F Q I+IDE + K R Sbjct: 153 SVLQYFELFFSQPVMQKIVDHSNIFGAMRHEARK-------RKWKDITVADLKSFIAMVIYMGI--------VKCFNLQDYWRMSDVYSLPYPAKIMSRIKFLTISWALHLSDP----KVDAENDKKRGTPQYDPLCKIKPLYQDIRDACKASFHPHQNISIDERMVASKAR 305
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Zebrafish
Match: pgbd4 (piggyBac transposable element derived 4 [Source:ZFIN;Acc:ZDB-GENE-091204-417]) HSP 1 Score: 58.5362 bits (140), Expect = 2.540e-8 Identity = 42/172 (24.42%), Postives = 76/172 (44.19%), Query Frame = 3 Query: 816 TVLDFFQMHFTDELTMEITKQTNDYAGLQLANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDW----TNTMPFFVDVFSRMRFLQIQWILHLSLPVPVGAVVIRSD------------KLEIVVNTVQDIC*HKFIQDQPITIDESTIGLKRR 1283 +VL +F++ F+ + +I +N + ++ R KWK ++ A++K + +++ M I +CF W ++P+ + SR++FL I W LHLS P V +D K++ + ++D C F Q I+IDE + K R Sbjct: 153 SVLQYFELFFSQPVMQKIVDHSNIFGAMRHEARK-------RKWKDITVADLKSFIAMVIYMGI--------VKCFNLQDYWRMSDVYSLPYPAKIMSRIKFLTISWALHLSDP----KVDAENDKKRGTPQYDPLCKIKPLYQDIRDACKASFHPHQNISIDERMVASKAR 305
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Zebrafish
Match: CABZ01069162.1 (pep scaffold:GRCz11:KN149950.1:74:5493:1 gene:ENSDARG00000115161.1 transcript:ENSDART00000191202.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CABZ01069162.1) HSP 1 Score: 50.8322 bits (120), Expect = 5.872e-6 Identity = 41/162 (25.31%), Postives = 70/162 (43.21%), Query Frame = 3 Query: 822 LDFFQMHFTDELTMEITKQTNDYAGLQLANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDWTNTMPFFVDVFSRMRFLQIQWILHLSLPV--------PVGAVVIRSDKLEIVVNTVQDIC*HKFIQDQPITIDESTIGLKRR 1283 L FQ+ FT + I + +N YA Q R WK +S ++K Y +++ M + + + D+ + + ++P + S +FL I LHLS PV A R K++ + + ++D C + Q I+IDE + K R Sbjct: 222 LQLFQLFFTPSVLQTIMQHSNAYATKQ-------RQGTDKSWKNISVEDLKSYLALVIFMGLLKVCALTDY----WRRSDVYSVPLPTRIMSCRKFLNIANALHLSDPVDDEANEGRKGTAAYDRLGKIKPLYDNIRDACRAFYHPGQNISIDERMVASKAR 372
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Xenopus
Match: dlgap5 (discs large homolog associated protein 5 [Source:Xenbase;Acc:XB-GENE-481549]) HSP 1 Score: 60.077 bits (144), Expect = 5.720e-9 Identity = 46/163 (28.22%), Postives = 73/163 (44.79%), Query Frame = 3 Query: 822 LDFFQMHFTDELTMEITKQTNDYAGLQLANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDWTNT----MPFFVDVFSRMRFLQIQWILHL-----SLPVPVGAVVIRSDKLEIVVNTVQDIC*HKFIQDQPITIDESTIGLKRR 1283 +DFFQ++ T+ + ++ TN YA LA+ PL RY+ W AEMK + G+ L M + ++ + W T +P F R R+ + LH ++P P R KL ++N++ + C + Q I IDES + K R Sbjct: 114 VDFFQLYITEAILQDMVLYTNLYAEQYLAHNPLPRYARAQAWHPTDIAEMKKFLGLTLAMGLIKANSLESY--------WDTTTVLSIPVFSATMPRNRYQLLLRFLHFNNNATAVP-PYVPGHDRLHKLRPLINSLSERCGEVYTPSQNICIDESLLLFKGR 267
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000024424.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV461698.1:3132:4553:-1 gene:ENSXETG00000015301.1 transcript:ENSXETT00000024424.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 59.3066 bits (142), Expect = 1.104e-8 Identity = 46/163 (28.22%), Postives = 72/163 (44.17%), Query Frame = 3 Query: 822 LDFFQMHFTDELTMEITKQTNDYAGLQLANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDWTNT----MPFFVDVFSRMRFLQIQWILHL-----SLPVPVGAVVIRSDKLEIVVNTVQDIC*HKFIQDQPITIDESTIGLKRR 1283 +DFFQ++ T+ + ++ TN YA LA PL RY+ W AEMK + G+ L M + ++ + W T +P F R R+ + LH ++P V R KL ++N++ + C + Q I IDES + K R Sbjct: 114 VDFFQLYITEAILQDMVLYTNLYAEQYLARNPLPRYARAQAWHPTDIAEMKKFLGLTLAMGLIKANSLESY--------WDTTTVLSIPVFSATMPRNRYQLLLRFLHFNNNATAVPPDVPG-HDRLHKLRPLINSLSERCGEVYTPSQNICIDESLLLFKGR 267
BLAST of DDE_Tnp_1_7 domain-containing protein vs. TrEMBL
Match: A0A1B6MGG4 (DDE_Tnp_1_7 domain-containing protein (Fragment) OS=Graphocephala atropunctata OX=36148 GN=g.845 PE=4 SV=1) HSP 1 Score: 119.783 bits (299), Expect = 1.427e-25 Identity = 62/158 (39.24%), Postives = 96/158 (60.76%), Query Frame = 3 Query: 822 LDFFQMHFTDELTMEITKQTNDYAGLQLA-NRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDWTNTMPFFVDVFSRMRFLQIQWILHLSLP---VPVGAVVIRSDKLEIVVNTVQDIC*HKFIQDQPITIDESTIGLKRR 1283 LD+FQ+ FTDEL M+I ++N +A ++ + PL RYS+W WK +S E+K + GVI+NM++N P + D+ FS +W + PFF + SR RF QI W LHLS P +P+ + RS K+ + +++ F + +++DEST+G K R Sbjct: 87 LDYFQLFFTDELFMQIAHESNAFAKQKIQISTPLTRYSVWHSWKDISLCEIKAFIGVIINMSLNPKPLLEDY----FSNNWLDNQPFFKKILSRERFFQIFWTLHLSPPSTTLPILGTLTRSGKVRKFLLYLENKFQEHFCPSKYLSLDESTVGFKGR 240
BLAST of DDE_Tnp_1_7 domain-containing protein vs. TrEMBL
Match: A0A1B6MI17 (DDE_Tnp_1_7 domain-containing protein OS=Graphocephala atropunctata OX=36148 GN=g.44843 PE=4 SV=1) HSP 1 Score: 122.479 bits (306), Expect = 3.206e-25 Identity = 63/167 (37.72%), Postives = 100/167 (59.88%), Query Frame = 3 Query: 798 ATNAIQTVLDFFQMHFTDELTMEITKQTNDYAGLQL-ANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDWTNTMPFFVDVFSRMRFLQIQWILHLSLP--VPVGAVVIRSDKLEIVVNTVQDIC*HKFIQDQPITIDESTIGLKRRFL 1289 + + T L+FFQ+ FTD L +EI K+TN YA ++ N PL + S+W W ++ +E+K + GVI+NM +N P + D+ FS +W + PFF DVFS+ RF+QI W LH+ P PV + RS K+ V + + ++ ++ +++DEST+G K R + Sbjct: 102 SNDKPSTPLEFFQLFFTDSLLIEIVKETNRYAAEKIQKNTPLQKKSVWWSWIDLTISELKAFLGVIINMGMNGKPEMTDY----FSTNWVDYQPFFKDVFSKERFMQIFWNLHICPPPSGPVAGTLTRSGKVRNVASYLDKKFREHYVPEKEVSVDESTVGFKGRIV 264
BLAST of DDE_Tnp_1_7 domain-containing protein vs. TrEMBL
Match: A0A1A9Z230 (DDE_Tnp_1_7 domain-containing protein OS=Glossina pallidipes OX=7398 PE=4 SV=1) HSP 1 Score: 106.686 bits (265), Expect = 8.964e-22 Identity = 65/169 (38.46%), Postives = 90/169 (53.25%), Query Frame = 3 Query: 786 TGSQATNAIQTVLDFFQMHFTDELTMEITKQTNDYAGLQLANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDWTNTMPFFVDVFSRMRFLQIQWILHLSLPVPVGAVVIRSDKLEIVVNTVQDIC*H---KFIQDQPITIDESTIGLKRR 1283 G Q +N I+ LDFF+++FTD L I K+TNDYA +L P + +IW W V+ E + GVILNM + N+ ++ C F T+ +PFF DVF+R RFLQI +LHL P G +++ N +Q I FI Q I +DES I K + Sbjct: 103 AGPQISNDIKEPLDFFRLYFTDALIDSIVKETNDYANSKLRKMPFSKITIWNTWSDVNRKEFLAFIGVILNMGTMPVVNLQEYWCTKF----TSKIPFFSDVFTRDRFLQIFLMLHLHKNAPEGRNTSLRTRIQKANNFLQHINSKFSAHFIPYQTICVDESIIKFKGK 267
BLAST of DDE_Tnp_1_7 domain-containing protein vs. TrEMBL
Match: E2BAB9 (PiggyBac transposable element-derived protein 4 (Fragment) OS=Harpegnathos saltator OX=610380 GN=EAI_11398 PE=4 SV=1) HSP 1 Score: 107.457 bits (267), Expect = 1.372e-20 Identity = 59/167 (35.33%), Postives = 101/167 (60.48%), Query Frame = 3 Query: 786 TGSQATNAIQTVLDFFQMHFTDELTMEITKQTNDYAGLQLANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDWTNTMPFFVDVFSRMRFLQIQWILHL-SLPVPVGAVVIRSDKLEIVVNTVQDIC*HKFIQDQPITIDESTIGLKRR 1283 TG + T L FFQ+ FTD+L +I +TN Y + ++ L SIW +WK V+ EMK +FGVI+NM + ++P++ D+ +++++ + +PFF +FSR RF+QI W LHL +LP + + ++ K+ ++ + +I ++ ++IDEST+G K R Sbjct: 15 TGPHVPSNCTTPLHFFQLFFTDDLIKKIVIETNIYTANIIQHKQLSIRSIWKQWKNVTECEMKAFFGVIINMGLINMPSLQDY----WARNFYSKIPFFSKIFSRDRFMQIFWALHLETLPRSMN-MTTKTRKISSYLDFLNKKFMEHYIPEKNLSIDESTVGFKGR 176
BLAST of DDE_Tnp_1_7 domain-containing protein vs. TrEMBL
Match: A0A482X6I1 (DDE_Tnp_1_7 domain-containing protein OS=Laodelphax striatellus OX=195883 GN=LSTR_LSTR000098 PE=4 SV=1) HSP 1 Score: 107.071 bits (266), Expect = 2.761e-20 Identity = 64/159 (40.25%), Postives = 91/159 (57.23%), Query Frame = 3 Query: 822 LDFFQMHFTDELTMEITKQTNDYAGLQL-ANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDWTNTMPFFVD-VFSRMRFLQIQWILHLSLPVPVGAV---VIRSDKLEIVVNTVQDIC*HKFIQDQPITIDESTIGLKRR 1283 L +FQ+ FTDEL ++I +TN YA ++ AN PL + S W W ++ E K + GVI+NM++N P + D+ FS DW + FF D +FS+ RF QI W LHLS P +G V V RS K++ VV ++ + ++I ESTI K R Sbjct: 114 LHYFQLFFTDELFLQIINETNRYAQEKIKANTPLTKNSTWHSWIDLTLPEFKAFLGVIMNMSLNPKPEMEDY----FSSDWLDYQTFFKDIIFSKERFFQIFWTLHLSPPNNIGPVLGTVTRSGKVKRVVQYLEKKFREYYCPSDTVSIGESTIDFKGR 268
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002004.1 (pep scaffold:Pmarinus_7.0:GL490362:1254:2954:1 gene:ENSPMAG00000001819.1 transcript:ENSPMAT00000002004.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 49.2914 bits (116), Expect = 2.320e-6 Identity = 46/163 (28.22%), Postives = 74/163 (45.40%), Query Frame = 3 Query: 816 TVLDFFQMHFTDELTMEITKQTNDYAGLQLANRPLCRYSIWTKWKAVSSAEMKVYFGVILNMTINDIPNVFDFRCF*FSKDWTNTMPFFVDVFSRMRFLQIQWIL--HLSLPVPVGAVVIRSDKLEIVVNTVQDIC*HKF----IQDQPITIDESTIGLKRRF 1286 T L F Q+ T EL M T +TN YA LAN+ + W+ V+ ++ Y G+ + M + +P + + +S +MP F + S RF I H S VP +D+L + V TV + KF ++ +++DE+T+ K R Sbjct: 15 TPLGFIQLFITRELLMFFTNETNSYANCALANKSAEERA---GWEGVNLMDIANYLGLTMAMGVASLPEIPMY----WSTGKPYSMPAFRETMSCKRFKSIGRFFNCHNSCAVPRD----NTDRL-LQVRTVMEYFQSKFKALYAPNRELSLDEATLEWKGRL 165 The following BLAST results are available for this feature:
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 3
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 2
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of DDE_Tnp_1_7 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of DDE_Tnp_1_7 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of DDE_Tnp_1_7 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 0
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017568 ID=SMED30017568|Name=DDE_Tnp_1_7 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2255bpback to top protein sequence of SMED30017568-orf-1 >SMED30017568-orf-1 ID=SMED30017568-orf-1|Name=SMED30017568-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=104bp MLPDGAVFARFPFTFPKTGSQATNAIQTVLDFFQMHFTDELTMEITKQTNback to top protein sequence of SMED30017568-orf-2 >SMED30017568-orf-2 ID=SMED30017568-orf-2|Name=SMED30017568-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=112bp MAKRFRGAEGLEQILAMDDDDDEGDSVANDDDNEIEDDLPDANLSSEDDEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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