tyramine beta-hydroxilase

Query:   27 VYRTEIMRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKL-CQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGF--DLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGND-VKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVF-------------ENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWN 1682
            +Y T +  + L+ +   L+       P  YH      EG  ++ W+V    E I  +L  ++L     F      G SD G+LEN+DL V+       +  D  +++ G+I  D +QDY L       E      +R   TCD  DY I+ GT +++   L+        ++   L   +  +QLL+  IP  E+     +ME+    I+IP+ +TTYWC + +LP    +HHIIKYE +++  ++ +VHHME+F C  +P  D V  F+GPC+S+ KP  L  CR V+AAWA+GA AF YPE+ G   GG   S Y  LE+H++N    +G  D+SG+RL+YT KLR+++AGI+ELGL YT    IPP++ +F L+GYC++KC++ ALP +GI++F SQLHTHLTG +V T   R  RE + +N+D HY PH+QEIR+L K+V+V PGD+L+T+C Y T +R   T GG  I +EMC+NY+ YYP+ +LELCKS+V D  F             E++      +  + F  V W+  N  +L+  Y  AP+   CN S +  F+G+WN
Sbjct:   21 MYSTAVA-IFLVILVAALQGSAPRESPLPYHIPLD-PEGSLELSWNVSYTQEAIHFQLLVRRLKAGVLF------GMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVHHMEVFQC--APEMDSVPHFSGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMCVNYVHYYPQTQLELCKSAV-DAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWN 578          

Query:  117 HATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFV--VNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNII-IFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCS---EKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVV----FENLPE---------------KEFRN--FKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLE 1727
            H T   +EG Y + WS   +  +I  +L      Q     + G GFS  G + ++D+ V  V   +    D  TN    + KD +QDY L+  + N         R+++TCD ND  I   T  +I  +  ++      + H    N     L+LL         +      ++    + IP   TTYWC++ ++P   +KHH+IK E VI    + +VHH+ L+ C  +  + V      C   + P     C  VI AWA+G   F+YP  VG  +G      Y +LE+H++N   ++G+IDNSGLRLFYT  +R+YDAG+IE GL  +  + IPP    F   G+C+    + + +A   +GI+VF   LH HL G  +  RHFRK +E+K L  D  +  ++QE + L +   +LPGD L+T C Y T +R E+T+GG+    EMCL+Y+ YYP+I L  C +S+ D++    F  + E               K+++N  F +  N+  W+ K      +     PV+  C+ +D+  +       + P +E R Y  E
Sbjct:   27 HRTLLDSEGKYWLGWSQRGS--QIAFRL------QVRTAGYVGFGFSPTGAMASADIVVGGVAHGRPYLQDYFTNANRELKKDAQQDYHLEYAMENSTHTIIEFTRELHTCDINDKSITDSTVRVIWAYHHEDAGEAGPKYHDS--NRGTKSLRLLNPEKTSVLSTALPY-FDLVNQDVPIPNKDTTYWCQMFKIPVFQEKHHVIKVEPVIQRGHESLVHHILLYQCSNNFNDSVLESGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHYDNPTYEEGLIDNSGLRLFYTMDIRKYDAGVIEAGLWVSLFHTIPPGMPEFQSEGHCTLECLEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGKEMKLLAYDDDFDFNFQEFQYLKEEQTILPGDNLITECRYNTKDRAEMTWGGLSTRSEMCLSYLLYYPRINLTRC-ASIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYKNLSFMDAMNKFKWTKKEGLSFNKLVLSLPVNVRCSKTDNAEWSIQGMTALPPDIE-RPYKAE 577          

Query:  321 DLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNII-IFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCS---EKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVV----FENLPE---------------KEFRN--FKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLE 1727
            D  TN    + KD +QDY L+  + N         R+++TCD ND  I   T  +I  +  ++      + H    N     L+LL         +      ++    + IP   TTYWC++ ++P   +KHH+IK E VI    + +VHH+ L+ C  +  + V      C   + P     C  VI AWA+G   F+YP  VG  +G      Y +LE+H++N   ++G+IDNSGLRLFYT  +R+YDAG+IE GL  +  + IPP    F   G+C+    + + +A   +GI+VF   LH HL G  +  RHFRK +E+K L  D  +  ++QE + L +   +LPGD L+T C Y T +R E+T+GG+    EMCL+Y+ YYP+I L  C +S+ D++    F  + E               K+++N  F +  N+  W+ K      +     PV+  C+ +D+  +       + P +E R Y  E
Sbjct:   21 DYFTNANRELKKDAQQDYHLEYAMENSTHTIIEFTRELHTCDINDKSITDSTVRVIWAYHHEDAGEAGPKYHDS--NRGTKSLRLLNPEKTSVLSTALPY-FDLVNQDVPIPNKDTTYWCQMFKIPVFQEKHHVIKVEPVIQRGHESLVHHILLYQCSNNFNDSVLESGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHYDNPTYEEGLIDNSGLRLFYTMDIRKYDAGVIEAGLWVSLFHTIPPGMPEFQSEGHCTLECLEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGKEMKLLAYDDDFDFNFQEFQYLKEEQTILPGDNLITECRYNTKDRAEMTWGGLSTRSEMCLSYLLYYPRINLTRC-ASIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYKNLSFMDAMNKFKWTKKEGLSFNKLVLSLPVNVRCSKTDNAEWSIQGMTALPPDIE-RPYKAE 509          

Query:   27 VYRTEIMRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKL-CQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGND-VKRFNGPCNSESKPMGLTMCRKVIAAWAMGA 902
            +Y T +  + L+ +   L+       P  YH      EG  ++ W+V    E I  +L  ++L     F      G SD G+LEN+DL V+                                                 D +      GT +++   L+        ++   L   +  +QLL+  IP  E+     +ME+    I+IP+ +TTYWC + +LP    +HHIIKYE +++  ++ +VHHME+F C  +P  D V  F+GPC+S+ KP  L  CR V+AAWA+GA
Sbjct:   19 MYSTAVA-IFLVILVAALQGSAPRESPLPYHIPLD-PEGSLELSWNVSYTQEAIHFQLLVRRLKAGVLF------GMSDRGELENADLVVL-----------------------------------------------WTDGDTAYFADGTVHLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVHHMEVFQC--APEMDSVPHFSGPCDSKMKPDRLNYCRHVLAAWALGA 255          

Query:  651 PASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRF--NGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNN----QDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPK----IELELCKSSVSDVVFENLP 1532
            P    TY+C  +++P +D++  +I ++      S   VHHM LF C          F   G C  ++          ++ AWA  AP    P+ VG  +GGE  S Y +L++H+ +    +D  K   D SG+ L  T   +   AG+    L  +    IP  +K           C  +  P   ++VF  ++HTH  G +V + +  ++ +   + R     P  Q    +   V+V  GD+L   C++    RTE T  G   +DEMC  YI YY +    +    C  +V+  +F  +P
Sbjct:   68 PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKAN---------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNK---DCSGVSLHLTRLPQPLIAGMY---LMMSVDTVIPAGEKVVN----SDISCHYKNYP---MHVFAYRVHTHHLG-KVVSGYRVRNGQWTLIGRQSPQLP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIP 342          

Query:  228 FPIWSG--------IGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLL----KDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVL----LQLLXXXXXXXXXXXXXXXMEITVNYI--------EIPASQTTYWCKVIQLPY--LDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSD----VVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPV---HQSCNMSDSDSFEGD-------WNAIITPILETRDYDLEKQSFEC 1745
            F IW G        +GFSD G   NSD+ +    K    D +TN+  +I  D +QD+ L    KD+I+        ++RK+ TCD  DY    GTT   I +     N+     VD  +   V+     +++        I     ++E  V  +         IP  +TTY C + ++P+  ++  +H+++ E  ++  ++ +VHHME+F C     ++V+ ++G CN   KP     C  VIAAWAMG     YP++ G PIGG+  + Y ++EIH+NN +  KG+ID+SG + F T +LR+YDAGI+ELGL Y++ N +PP QK++A++GYC  +C++  LP  GI +F SQLH HLTG ++ T  +R    +  +NRD+HY PH+Q ++ L  +V V+PGD LVTTC+Y T  R++VTFGG  I DEMC+NYI+YYP  ++E+CKS++S+      F      + +  + +    N  D  + + E FY+   V   + +C  S+ + FE +       W  +  P   +  +   +  F+C
Sbjct:   48 FSIWFGASTPDVLFLGFSDFGDTNNSDVLMYYNSKKEIKDAYTNRDFKITSDLQQDFQLLRKRKDHIV--------VRRKLTTCDSRDYAFLPGTTQFYIAASWGSTNL-----VDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKVVIVNSNSPDPIPNVETTYKCIIRKMPFDTVNNMYHVVRMEPYVTPGNEHLVHHMEIFMC----RDEVEEWSGSCNDPKKPPKSKSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEIHYNNPELHKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTKN-LPEEGINIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTLVTTCVYDTRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYFSERHGMDGKRMQISDMYSNVKDWGNGVDEEFYNVLNVGNMNMNCLKSNGEPFEFESKDSRQSWENMARPTFVSGSFITTRDRFQC 575          

Query:  228 FPIWSG--------IGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLL----KDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVL----LQLLXXXXXXXXXXXXXXXMEITVNYI--------EIPASQTTYWCKVIQLPY--LDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSD----VVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPV---HQSCNMSDSDSFEGD-------WNAIITPILETRDYDLEKQSFEC 1745
            F IW G        +GFSD G   NSD+ +    K    D +TN+  +I  D +QD+ L    KD+I+        ++RK+ TCD  DY    GTT   I +     N+     VD  +   V+     +++        I     ++E  V  +         IP  +TTY C + ++P+  ++  +H+++ E  ++  ++ +VHHME+F C     ++V+ ++G CN   KP     C  VIAAWAMG     YP++ G PIGG+  + Y ++EIH+NN +  KG+ID+SG + F T +LR+YDAGI+ELGL Y++ N +PP QK++A++GYC  +C++  LP  GI +F SQLH HLTG ++ T  +R    +  +NRD+HY PH+Q ++ L  +V V+PGD LVTTC+Y T  R++VTFGG  I DEMC+NYI+YYP  ++E+CKS++S+      F      + +  + +    N  D  + + E FY+   V   + +C  S+ + FE +       W  +  P   +  +   +  F+C
Sbjct:   69 FSIWFGASTPDVLFLGFSDFGDTNNSDVLMYYNSKKEIKDAYTNRDFKITSDLQQDFQLLRKRKDHIV--------VRRKLTTCDSRDYAFLPGTTQFYIAASWGSTNL-----VDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKVVIVNSNSPDPIPNVETTYKCIIRKMPFDTVNNMYHVVRMEPYVTPGNEHLVHHMEIFMC----RDEVEEWSGSCNDPKKPPKSKSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEIHYNNPELHKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTKN-LPEEGINIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTLVTTCVYDTRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYFSERHGMDGKRMQISDMYSNVKDWGNGVDEEFYNVLNVGNMNMNCLKSNGEPFEFESKDSRQSWENMARPTFVSGSFITTRDRFQC 596          

Query:  228 FPIWSG--------IGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLL----KDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVL----LQLLXXXXXXXXXXXXXXXMEITVNYI--------EIPASQTTYWCKVIQLPY--LDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSD----VVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPV---HQSCNMSDSDSFEGD-------WNAIITPILETRDYDLEKQSFEC 1745
            F IW G        +GFSD G   NSD+ +    K    D +TN+  +I  D +QD+ L    KD+I+        ++RK+ TCD  DY    GTT   I +     N+     VD  +   V+     +++        I     ++E  V  +         IP  +TTY C + ++P+  ++  +H+++ E  ++  ++ +VHHME+F C     ++V+ ++G CN   KP     C  VIAAWAMG     YP++ G PIGG+  + Y ++EIH+NN +  KG+ID+SG + F T +LR+YDAGI+ELGL Y++ N +PP QK++A++GYC  +C++  LP  GI +F SQLH HLTG ++ T  +R    +  +NRD+HY PH+Q ++ L  +V V+PGD LVTTC+Y T  R++VTFGG  I DEMC+NYI+YYP  ++E+CKS++S+      F      + +  + +    N  D  + + E FY+   V   + +C  S+ + FE +       W  +  P   +  +   +  F+C
Sbjct:  120 FSIWFGASTPDVLFLGFSDFGDTNNSDVLMYYNSKKEIKDAYTNRDFKITSDLQQDFQLLRKRKDHIV--------VRRKLTTCDSRDYAFLPGTTQFYIAASWGSTNL-----VDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKVVIVNSNSPDPIPNVETTYKCIIRKMPFDTVNNMYHVVRMEPYVTPGNEHLVHHMEIFMC----RDEVEEWSGSCNDPKKPPKSKSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEIHYNNPELHKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTKN-LPEEGINIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTLVTTCVYDTRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYFSERHGMDGKRMQISDMYSNVKDWGNGVDEEFYNVLNVGNMNMNCLKSNGEPFEFESKDSRQSWENMARPTFVSGSFITTRDRFQC 647          

Query:  666 TYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGND-----VKRFNGPCNSESKPMGLTMCRK--VIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVE---TRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIEL 1484
            +Y C  ++L   D+++++  ++A+   T++G  HH+ LF C   PG+D         N P   +  P   T   K  ++ AWA+ AP    P+ VG  +GG++   + ++++H+ +  ++    D +GL + +T++ +   A  +   L  T       K +SF  +    E           ++ F  + HTH  G +V     +  +KH +   L   +  Q     + +  + + +  GD++   CI +     +++ G  E  DEMC  YI Y+   E+
Sbjct:   38 SYLCTSLELS--DQENYLTGFKAL---TTKGTAHHILLFGC-EEPGSDELVWDCGEMNKP--DDEMPRAPTCGSKPAILYAWALDAPPLELPQDVGFRVGGDSNIRHLVMQVHYMHSKQEP---DETGLEITHTEEPQPKLAATM---LLVTGGTLPRNKTESFETACMIEEDVV--------MHPFAYRTHTHRHGKEVSGWLVKEDQKHEDHWKLIGRRDPQLAQMFVPVEDQAMTIQQGDMVTARCILQNNENRDISMGATE-EDEMCNFYIMYWTDGEV 297          

Query:  153 IYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDL-FVVNRLKFLGF--DLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFL-------NYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPY-LDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFEN----LPEKEFRNF-------KETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEG--DWNAIITPILETR 1712
            + W V+   +++   L    N+Q     W  +GFS  G L ++D+ F  N+  F     D +T+  G+ +   R+DY     +   ++F    +RK +TCD  D ++  GT  ++    + +  +  E H   L          V +LQLLR+   +   +     MEIT+    IP+ +TTYWC V +L   L ++HHI+++E +I   + GIVHHME+FHC      ++  +NG C  E  P    +C KV+  WAMGA  FTYP + G PIGG  F+ Y  LE+HFNN +++ G++DNSG R+  +  LRQYDA ++ELGLEYT+K  IPP Q +F LSGYC   C+R ALPA GI +FGSQLHTHL G++V TRHFR  +EL+ +NRD +Y  H+QE+R L     VLPGD LVTTC Y T +      GG  I+DEMC+NYI YYP  +LE+CKSSVS+   EN    +   E ++           +  + W+      L   Y + P+   CN SD   FEG   W  +    ++ R
Sbjct:  108 LSWMVDWYKQEVLFHLQNAFNEQHR---WFYLGFSKRGGLADADICFFENQNGFFNAVTDTYTSPDGQWV---RRDYQQDCEVFKMDEFTLAFRRKFDTCDPLDLRLHEGTMYVVW--ARGETELALEDHQFALPNVTAPHEAGVKMLQLLRADKILIPETELDH-MEITLQEAPIPSQETTYWCHVQRLEGNLRRRHHIVQFEPLIR--TPGIVHHMEVFHCEAGEHEEIPLYNGDC--EQLPPRAKICSKVMVLWAMGAGTFTYPPEAGLPIGGPGFNPYVRLEVHFNNPEKQSGLVDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPLSGYCVADCTRAALPATGIIIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLHYKPRVLPGDALVTTCYYNTKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYFIYMKRTEHQHGVHLNGARSSNYRSIEWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFEGRSSWEGVAATPVQIR 638          

Query:  153 IYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDL-FVVNRLKFLGF--DLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFL-------NYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPY-LDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFEN----LPEKEFRNF-------KETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEG--DWNAIITPILETR 1712
            + W V+   +++   L    N+Q     W  +GFS  G L ++D+ F  N+  F     D +T+  G+ +   R+DY     +   ++F    +RK +TCD  D ++  GT  ++    + +  +  E H   L          V +LQLLR+   +   +     MEIT+    IP+ +TTYWC V +L   L ++HHI+++E +I   + GIVHHME+FHC      ++  +NG C  E  P    +C KV+  WAMGA  FTYP + G PIGG  F+ Y  LE+HFNN +++ G++DNSG R+  +  LRQYDA ++ELGLEYT+K  IPP Q +F LSGYC   C+R ALPA GI +FGSQLHTHL G++V TRHFR  +EL+ +NRD +Y  H+QE+R L     VLPGD LVTTC Y T +      GG  I+DEMC+NYI YYP  +LE+CKSSVS+   EN    +   E ++           +  + W+      L   Y + P+   CN SD   FEG   W  +    ++ R
Sbjct:  108 LSWMVDWYKQEVLFHLQNAFNEQHR---WFYLGFSKRGGLADADICFFENQNGFFNAVTDTYTSPDGQWV---RRDYQQDCEVFKMDEFTLAFRRKFDTCDPLDLRLHEGTMYVVW--ARGETELALEDHQFALPNVTAPHEAGVKMLQLLRADKILIPETELDH-MEITLQEAPIPSQETTYWCHVQRLEGNLRRRHHIVQFEPLIR--TPGIVHHMEVFHCEAGEHEEIPLYNGDC--EQLPPRAKICSKVMVLWAMGAGTFTYPPEAGLPIGGPGFNPYVRLEVHFNNPEKQSGLVDNSGFRIKMSKTLRQYDAAVMELGLEYTDKMAIPPGQTAFPLSGYCVADCTRAALPATGIIIFGSQLHTHLRGVRVLTRHFRGEQELREVNRDDYYSNHFQEMRTLHYKPRVLPGDALVTTCYYNTKDDKTAALGGFSISDEMCVNYIHYYPATKLEVCKSSVSEETLENYFIYMKRTEHQHGVHLNGARSSNYRSIEWTQPRIDQLYTMYMQEPLSMQCNRSDGTRFEGRSSWEGVAATPVQIR 638          

Query:  114 YHATYSRTE-----GVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLG----FDLHTNKY---GRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXX-XXXXXXXXXXXXMEITVNYIEIPASQTT-YWCKVIQLPYLDKKHHIIKYEAVISAT-SQGIVHHMELFHCIRS--PGND-------VKRFNGPCNSES-KPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS 1499
            +H  + R E     G+Y + W +  N   I  ++            ++G+GFS  G+L  +D+ ++      G     D H   +   G  ++D+ Q+Y + D   N        +RK+ TCD  D  +   T  ++ +S+     ++  L     +  V  LQL        S      +  +ITVN + I  S  T YWCK+++LP L  K HII YE ++S    + +VHHM LF C      G+D       V+     CNS    P     C   +A W++G+     P   G P+GG +  +Y +LEIH++N D K+ + D+SG R+ YT  LR YD+GI+  G+  +E   IPP QK +   G C   CS    P +GI +    LH+H  G  +  RH R  +EL P+  D++Y   +Q++  L     VLPGD L+T C Y+T  R   TFGG    +EMCL +I YYPKIE+  C S
Sbjct:   40 HHKNWVRNEMMDSLGLYWLKWWINANENSIYFEVTVHTRG------FAGLGFSKDGRLARADMVLMWVDDATGHPNVLDCHGALHPSSGPPLQDDTQNYDVLDGKQNGTHTILKFKRKIETCDPFDIPLSADTFKVL-WSIGENDPIHGNLDWQGQSRGVKALQLFSPMFTKNSHSIEGIQKWDITVNNVTIDRSMDTLYWCKIVRLPELTGKQHIIGYEPLLSGKYERNVVHHMTLFECQSKIYSGSDPSSWDLWVRSAGTVCNSNLLTPRDWDSCSTPVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEIHYDNPDGKESV-DHSGFRIHYTPNLRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSVMFPKDGIKIISGTLHSHQAGRTISLRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYLITDCSYETKYRKRPTFGGYSTKEEMCLTFITYYPKIEMSGCYS 518          

Query:  114 YHATYSRTE-----GVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLG----FDLHTNKY---GRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXX-XXXXXXXXXXXXMEITVNYIEIPASQTT-YWCKVIQLPYLDKKHHIIKYEAVISAT-SQGIVHHMELFHCIRS--PGND-------VKRFNGPCNSES-KPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS 1499
            +H  + R E     G+Y + W +  N   I  ++            ++G+GFS  G+L  +D+ ++      G     D H   +   G  ++D+ Q+Y + D   N        +RK+ TCD  D  +   T  ++ +S+     ++  L     +  V  LQL        S      +  +ITVN + I  S  T YWCK+++LP L  K HII YE ++S    + +VHHM LF C      G+D       V+     CNS    P     C   +A W++G+     P   G P+GG +  +Y +LEIH++N D K+ + D+SG R+ YT  LR YD+GI+  G+  +E   IPP QK +   G C   CS    P +GI +    LH+H  G  +  RH R  +EL P+  D++Y   +Q++  L     VLPGD L+T C Y+T  R   TFGG    +EMCL +I YYPKIE+  C S
Sbjct:   40 HHKNWVRNEMMDSLGLYWLKWWINANENSIYFEVTVHTRG------FAGLGFSKDGRLARADMVLMWVDDATGHPNVLDCHGALHPSSGPPLQDDTQNYDVLDGKQNGTHTILKFKRKIETCDPFDIPLSADTFKVL-WSIGENDPIHGNLDWQGQSRGVKALQLFSPMFTKNSHSIEGIQKWDITVNNVTIDRSMDTLYWCKIVRLPELTGKQHIIGYEPLLSGKYERNVVHHMTLFECQSKIYSGSDPSSWDLWVRSAGTVCNSNLLTPRDWDSCSTPVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEIHYDNPDGKESV-DHSGFRIHYTPNLRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSVMFPKDGIKIISGTLHSHQAGRTISLRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYLITDCSYETKYRKRPTFGGYSTKEEMCLTFITYYPKIEMSGCYS 518          

Query:  198 LCQKLNKQFSFPI------WSGIGFSDHGKLENSDLFV--VNRLKFLGFDLHTNKYG--RIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKN-DYQIDRGTTNII-IFSLKNKQNMNNELHV--DFLNYF-----VVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTT-YWCKVIQLPYLDKKHHIIKYEAVI-SATSQGIVHHMELFHCIRSPGN--DVKRFNG-PC-NSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNN------QDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPK-IELELCKS 1499
            L Q +N+  +F I      + G GFS  G L  +D+ +  V++ +    D H  + G    + D  QDY+L     N        +RK++TCD + D  I   T  ++ ++  ++  + +       D    F     +VL+Q  +  +P        R +E+    +E+PA     +WCK+ +L  +++KHH+I+YE +  S++S   + H+ L  C  +     ++ R  G PC  + S P+    C  ++A+W+ G+  FTYP + G PI     + Y ++E H+NN      Q   + + DNSGL++++T  LR  DAG + +G++   ++ IPP QK     G C E C+  A P  GI +F   + TH  G +V+ R  R+  EL P+  D +    YQ+ R LP+ V+ +PGD L+  CIY +++R  +T GG+ + +E C     YYP+  +L  C S
Sbjct:  122 LWQIINQDITFEIQARTLGYVGFGFSPDGNLAGADMAIGWVDKGQTYFQDRHVTRNGDPEPVVDPSQDYMLMLGYENATHTVLRFRRKLDTCDPSHDIAITNDTMRLLYMYHAQDPPHGSVRPGTLPDPARAFRPYRPMVLMQRAQLPMPSPTHDERVRVLELRNEDVELPAGDLPLFWCKMFKLEDINRKHHLIRYEPIYDSSSSVHYLQHITLHECQGAHAELEEMAREQGRPCLGARSIPLA---CNAIVASWSRGSEGFTYPHEAGYPIESRQ-AKYYLMETHYNNLKPDFAQLHARQMADNSGLKIYFTHVLRPNDAGTLSIGMDPNWRHIIPPGQKRVVSEGQCIEDCTGYAFPQQGINIFAVMMRTHQIGKEVKLRQIRQTEELPPIAHDSNIDVAYQDFRRLPQSVHSMPGDRLIAECIYDSSSRKAITLGGLTMKEESCTVLTLYYPRQKKLTTCHS 583          

Query:  246 IGFSDHGKLENSDLFVV---NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGND-VKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFE---------------NLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRR 1757
            +G SD G+  N+DL ++       + G D  ++  GR+  D +QDY L +   + E F    +R  +TCD +DY I+ GT +II   L++     +EL++  L   V  + LLR   P   +    R++E+    + IP  +TTYWC + QLP    K+HI+ YE+VI+  ++ IVHH+E+F C  SP  D V +++G C+S+ KP  L  CR V+AAWAMGA  F YP   G P+GGE  S +  LE+H++N     G  D+SG+RL+Y+  LR++DAGI+ELGL YT    IPP+Q+SF L+GYC+ KC++ ALP  GI++F SQLHTHL G+ V T   R  +E++ +  DKH+  HYQ IR+L K+V VLPGD L+TTC + T +R++VT GG  I +EMC+NY+ YYP+ +LELCKS V     +               + P+    + +E F+ V+W   + ++L   Y  AP    CN S +  F GDW     P++  +   L++  + C + R
Sbjct:   83 LGMSDRGEPTNADLVILWDDGHKSYFG-DAWSDSEGRVTLDTQQDYQLLETHQSTEGFFLLFKRSFSTCDPHDYIIEEGTVHIIYAMLEHPILSLHELNISRLQPGVQRVLLLRPDTPSPHLPKDVRTLEVLAPDVIIPTQETTYWCHIYQLPPNLPKNHIVMYESVITPGNEAIVHHIEVFEC--SPQMDIVPQYSGSCDSKMKPRNLNYCRHVLAAWAMGAEPFYYPADAGLPMGGEGSSRFLRLEVHYHNPLLLSGRRDSSGIRLWYSPSLRRFDAGIMELGLVYTPVMAIPPRQRSFQLTGYCTAKCTQTALPVGGIHIFASQLHTHLAGLGVRTVLVRGGQEVEVVQEDKHFSTHYQIIRVLQKMVTVLPGDALLTTCRFNTEDRSKVTVGGFGIMEEMCVNYVHYYPRTQLELCKSHVDTDYLQKYFSLINRFQGRESCSCPQT---SVEEQFSSVSWDSFSGEVLNSLYVTAPFSMHCNQSTAQLFPGDWEKQEIPVVTAQ---LQRAPYPCEINR 596          

Query:  246 IGFSDHGKLENSDLFVV---NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGND-VKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFE---------------NLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRR 1757
            +G SD G+  N+DL ++       + G D  ++  GR+  D +QDY L +   + E F    +R  +TCD +DY I+ GT +II   L++     +EL++  L   V  + LLR   P   +    R++E+    + IP  +TTYWC + QLP    K+HI+ YE+VI+  ++ IVHH+E+F C  SP  D V +++G C+S+ KP  L  CR V+AAWAMGA  F YP   G P+GGE  S +  LE+H++N     G  D+SG+RL+Y+  LR++DAGI+ELGL YT    IPP+Q+SF L+GYC+ KC++ ALP  GI++F SQLHTHL G+ V T   R  +E++ +  DKH+  HYQ IR+L K+V VLPGD L+TTC + T +R++VT GG  I +EMC+NY+ YYP+ +LELCKS V     +               + P+    + +E F+ V+W   + ++L   Y  AP    CN S +  F GDW     P++  +   L++  + C + R
Sbjct:   83 LGMSDRGEPTNADLVILWDDGHKSYFG-DAWSDSEGRVTLDTQQDYQLLETHQSTEGFFLLFKRSFSTCDPHDYIIEEGTVHIIYTMLEHPILSLHELNISRLQPGVQRVLLLRPDTPSPHLPKDVRTLEVLAPDVIIPTQETTYWCHIYQLPPNLPKNHIVMYESVITPGNEAIVHHIEVFEC--SPQMDIVPQYSGSCDSKMKPRNLNYCRHVLAAWAMGAEPFYYPADAGLPMGGEGSSRFLRLEVHYHNPLLLSGRRDSSGIRLWYSPSLRRFDAGIMELGLVYTPVMAIPPRQRSFQLTGYCTAKCTQTALPVGGIHIFASQLHTHLAGLGVRTVLVRGGQEVEVVQEDKHFSTHYQIIRVLQKMVTVLPGDALLTTCRFNTEDRSKVTVGGFGIMEEMCVNYVHYYPRTQLELCKSHVDTDYLQKYFSLINRFQGRESCSCPQT---SVEEQFSSVSWDSFSGEVLNSLYVTAPFSMHCNQSTAQLFPGDWEKQEIPVVTAQ---LQRAPYPCEINR 596          

Query:  243 GIGFSDHGKLENSDLF---VVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPA---NGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS------------------SVSDVVFENLPEKEFRN--FKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSF 1667
            G G S  G + +SD+    V+N   +L  D  T+   ++ +D  Q+Y L     N         R + TCD ND +I  G+T  +I++   +    + L    +N     L+LL      S  + +    ++    + +P   TTYWC++ + P + KKHH+I+ E +I    + +VHH+ L+ C  +           C   + P     C  V+ AWA+G   FTYP  VG  IG      Y  LEIHF+N   + GI+D+SGLRL+Y+  LR+YDAG+IE G+  +  + +PP    +   G+C+++C +++L +   +G++VF   LH HL G  +  RHFR+  EL+PL  D  +  ++QE + L +   +LPGD L+T C Y T  R  +T+GG+   +EMCL+++ YYP++ L  C+S                   V+   F     K++ N  F E  ++  WS K  K       + P++  C+ +  D +
Sbjct:   63 GFGLSPTGAMSSSDIVIGGVLNGSPYL-LDYFTDSNRKVHRDPLQNYELLYGRENDTHTVLAFSRNLQTCDDND-KIITGSTVRVIWAFHTEDVGESGLVYHGMNRGRKSLRLLNPGTGSSIPAGTAF-FDLQNKEVPVPHKDTTYWCQIFRFPEMKKKHHVIRIEPLIQKGHENLVHHILLYQCDSNLNKSEVNRGHECYHPNMPDSFLTCETVLFAWAIGGEGFTYPPHVGMSIGTSIDPVYVQLEIHFDNPSLQGGIVDSSGLRLYYSPSLRRYDAGVIETGVWVSLYHMLPPGMTDYITEGHCTQECLQESLDSEMPSGVHVFAVLLHAHLAGRAITARHFRQQLELQPLASDDQFDFNFQEFQPLSQERLILPGDSLITECRYNTKGRMNMTWGGLSTREEMCLSFLLYYPRVNLAKCESLPEIAGQLKFIGVTEIQEPVTTWPFVIKSPKKYSNLSFTEAMDKYKWSMKKGKSFNDIVRKLPMNVRCSKTGQDEW 560          

Query:  243 GIGFSDHGKLENSDLF---VVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPA---NGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS------------------SVSDVVFENLPEKEFRN--FKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSF 1667
            G G S  G + +SD+    V+N   +L  D  T+   ++ +D  Q+Y L     N         R + TCD ND +I  G+T  +I++   +    + L    +N     L+LL      S  + +    ++    + +P   TTYWC++ + P + KKHH+I+ E +I    + +VHH+ L+ C  +           C   + P     C  V+ AWA+G   FTYP  VG  IG      Y  LEIHF+N   + GI+D+SGLRL+Y+  LR+YDAG+IE G+  +  + +PP    +   G+C+++C +++L +   +G++VF   LH HL G  +  RHFR+  EL+PL  D  +  ++QE + L +   +LPGD L+T C Y T  R  +T+GG+   +EMCL+++ YYP++ L  C+S                   V+   F     K++ N  F E  ++  W+ K  K       + P++  C+ +  D +
Sbjct:   63 GFGLSPTGAMSSSDIVIGGVLNGSPYL-LDYFTDSNRKVHRDPLQNYELLYGRENDTHTVLAFSRNLQTCDDND-KIITGSTVRVIWAFHAEDVGESGLVYHGMNRGRKSLRLLNPGTGPSIPAGTAF-FDLQNKEVPVPHKDTTYWCQIFRFPEMKKKHHVIRIEPLIQKGHENLVHHILLYQCDSNLNKSEVNRGHECYHPNMPDSFLTCETVLFAWAIGGEGFTYPPHVGMSIGTSIDPVYVQLEIHFDNPSLQGGIVDSSGLRLYYSPSLRRYDAGVIETGVWVSLYHMLPPGMTDYITEGHCTQECLQESLDSEMPSGVHVFAVLLHAHLAGRAITARHFRQQLELQPLASDDQFDFNFQEFQPLSQERLILPGDSLITECRYNTKGRMNMTWGGLSTREEMCLSFLLYYPRVNLAKCESLPEIAGQLKFIGVTEIQEPVTTWPFVIKSPKKYSNLSFTEAMDKYKWTMKKGKSFNDIVRKLPMNVRCSKTGQDEW 560          

Query:  243 GIGFSDHGKLENSDLF---VVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS------------------SVSDVVFENLPEKEFRN--FKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSF 1667
            G G S  G + +SD+    V+N   +L  D  T+   ++ +D  Q+Y L     N         R + TCD ND +I  G+T  +I++   +    + L    +N     L+LL      S  + +    ++    + +P   TTYWC++ + P + KKHH+I+ E +I    + +VHH+ L+ C  +           C   + P     C  V+ AWA+G   FTYP  VG  IG      Y  LEIHF+N   + GI+D+SGLRL+Y+  LR+YDAG+IE G+  +  + +PP    +   G+C+++C  Q +P+ G++VF   LH HL G  +  RHFR+  EL+PL  D  +  ++QE + L +   +LPGD L+T C Y T  R  +T+GG+   +EMCL+++ YYP++ L  C+S                   V+   F     K++ N  F E  ++  W+ K  K       + P++  C+ +  D +
Sbjct:   63 GFGLSPTGAMSSSDIVIGGVLNGSPYL-LDYFTDSNRKVHRDPLQNYELLYGRENDTHTVLAFSRNLQTCDDND-KIITGSTVRVIWAFHAEDVGESGLVYHGMNRGRKSLRLLNPGTGPSIPAGTAF-FDLQNKEVPVPHKDTTYWCQIFRFPEMKKKHHVIRIEPLIQKGHENLVHHILLYQCDSNLNKSEVNRGHECYHPNMPDSFLTCETVLFAWAIGGEGFTYPPHVGMSIGTSIDPVYVQLEIHFDNPSLQGGIVDSSGLRLYYSPSLRRYDAGVIETGVWVSLYHMLPPGMTDYITEGHCTQEC-LQEMPS-GVHVFAVLLHAHLAGRAITARHFRQQLELQPLASDDQFDFNFQEFQPLSQERLILPGDSLITECRYNTKGRMNMTWGGLSTREEMCLSFLLYYPRVNLAKCESLPEIAGQLKFIGVTEIQEPVTTWPFVIKSPKKYSNLSFTEAMDKYKWTMKKGKSFNDIVRKLPMNVRCSKTGQDEW 555          

Query:   18 NLIVYRTEIMRLILLHVFIILKIVISYTKPYQYHATYS-----RTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV--NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFL-NYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFE------------NLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDW 1679
            NL +     +   +L VF+IL +        Q  +++        +G   +YW+V  + + +  ++   L K   F +    G SD G  E++D+ V+  N L     D  +++ G++  D +QDY L +   + E      +R   TCD  DY I+ GT ++I   L+   +  + + V  + N  +  +QLL+  +PI  +     +ME+    + IPA +TTYWC + +LP    KHHI+ YE VI+   + IVHH+E+F C  S    + R++GPC+S+ KP  L  CR V+AAWAMGA AF YPE+ G   GG + S Y  LE+H++N  E KG+ D+SG+RL+YT  LR+YDAGI+E+GL Y+    IPP QK F L+GYC++KC+ +ALP+NGI +F SQLHTHL G  V     R+ +E + +N D HY PH+QEIR+L K V+VLPGD++VT+C Y T +R  +T GG  ITDEMC+NY+ YYP+ +LELCKS V     +            ++         + F  V W+  ++ +L+  Y  AP+   CN S +  F G+W
Sbjct:   11 NLRIREVVPVYFTMLAVFMILLVASLQGPSRQQKSSFPYQVPLDPQGSLQLYWNVSYSEKVVYFRI---LIKDLKFGLI--FGMSDRGDFEDADMAVLWTNELGSFFGDAWSDQKGQLHMDSQQDYELLNAQQSQEGLYLLFRRPFATCDPKDYLIEDGTVHLIYALLEKPFSTLSSIDVSAIKNRGLQRVQLLKPDLPIPRLPADVLNMEVRAPQVLIPAKETTYWCHITELPKDFTKHHIVMYEPVITKGHEAIVHHIEVFQCA-SNYYTIPRYDGPCDSKMKPQSLNSCRHVLAAWAMGAKAFYYPEESGLAFGGPDSSRYLRLEVHYHNPLELKGLRDSSGIRLYYTSTLRRYDAGIMEVGLVYSPVMAIPPGQKDFLLTGYCTDKCTDRALPSNGIKIFASQLHTHLGGRGVPPILVREGKEAEVVNADGHYSPHFQEIRMLKKAVHVLPGDVMVTSCSYNTEDRKNITVGGFSITDEMCVNYVHYYPRTDLELCKSMVDPGYLQKYFHMVNRFNSDDVSTSPNTTVTKQFQEVPWNSFSAGVLKSLYSFAPISMHCNRSSAVRFPGEW 578          

Query:   18 NLIVYRTEIMRLILLHVFIILKIVISYTKPYQYHATYS-----RTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV--NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFL-NYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFE------------NLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPI 1700
            NL +     +   +L VF+IL +        Q  +++        +G   +YW+V  + + +  ++   L K   F +    G SD G  E++D+ V+  N L     D  +++ G++  D +QDY L +   + E      +R   TCD  DY I+ GT ++I   L+   +  + + V  + N  +  +QLL+  +PI  +     +ME+    + IPA +TTYWC + +LP    KHHI+ YE VI+   + IVHH+E+F C  S    + R++GPC+S+ KP  L  CR V+AAWAMGA AF YPE+ G   GG + S Y  LE+H++N  E KG+ D+SG+RL+YT  LR+YDAGI+E+GL Y+    IPP QK F L+GYC++KC+ +ALP+NGI +F SQLHTHL G  V     R+ +E + +N D HY PH+Q        V+V  GD++VT+C Y T +R  +T GG  ITDEMC+NY+ YYP+ +LELCKS V     +            ++         + F  V W+  ++ +L+  Y  AP+   CN S +  F    N    PI
Sbjct:   11 NLRIREVVPVYFTMLAVFMILLVASLQGPSRQQKSSFPYQVPLDPQGSLQLYWNVSYSEKVVYFRI---LIKDLKFGLI--FGMSDRGDFEDADMAVLWTNELGSFFGDAWSDQKGQLHMDSQQDYELLNAQQSQEGLYLLFRRPFATCDPKDYLIEDGTVHLIYALLEKPFSTLSSIDVSAIKNRGLQRVQLLKPDLPIPRLPADVLNMEVRAPQVLIPAKETTYWCHITELPKDFTKHHIVMYEPVITKGHEAIVHHIEVFQCA-SNYYTIPRYDGPCDSKMKPQSLNSCRHVLAAWAMGAKAFYYPEESGLAFGGPDSSRYLRLEVHYHNPLELKGLRDSSGIRLYYTSTLRRYDAGIMEVGLVYSPVMAIPPGQKDFLLTGYCTDKCTDRALPSNGIKIFASQLHTHLGGRGVPPILVREGKEAEVVNADGHYSPHFQ--------VSVYGGDVMVTSCSYNTEDRKNITVGGFSITDEMCVNYVHYYPRTDLELCKSMVDPGYLQKYFHMVNRFNSDDVSTSPNTTVTKQFQEVPWNSFSAGVLKSLYSFAPISMHCNRSSAVRFPVSINTGEPPI 577          

Query:  243 GIGFSDHGKLENSDLFV--VNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPA---NGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS------------------SVSDVVFENLPEKEFRN--FKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRRS 1760
            G GFS +G + +SD+ +  V   K    D +++    + +D  Q+YLL+  + N         R ++TCD ND  I   T  +I ++  N    +       LN     L+LL       +   +      T   + IP   TTYWC++ ++P L+KKHH++K E +I + ++ +VHH+ L+ C R+  + V  +   C   + P     C  V+ AWA+G   FT+P   G  +G      Y ++EIH++N  +++G+ DNSG+RL+YT  +R+YDAG++E G+  +  + IPP+   F   G+C+ +C  +AL A    GI+VF   LH+HL G  +  RH+RK  E KPL  D  Y  ++QE + L +   +LPGD +VT C Y T  RT +T+GG+   DEMCL+++ YYPKI L  C+S                   V+   F     K++ N  F E  N   WS K      +   + P++  C+  +S+ +      I++P      Y  + + F CL   S
Sbjct:   58 GFGFSPNGDMASSDIVIGGVEEGKPYLQDFYSDGNRILHRDPHQNYLLEYAMENSTHTILKFSRDLHTCDPNDKTITESTIRVI-WAYHNDDIGHVGPTYHGLNRGRKSLRLLNPEKTYIKSVDTPS-FNFTNKNVPIPYKDTTYWCQMFKMPALNKKHHVVKIEPLIQSGNENLVHHILLYECDRNVNDSVLDYGHECYHPNMPDVFHTCETVVFAWAIGGEGFTFPSHAGLSLGMPTDPKYVLMEIHYDNPSQQEGLTDNSGIRLYYTHHVRKYDAGVLETGIWVSLYHMIPPRMAQFISEGHCTMECLEEALSAENPEGIHVFAVLLHSHLAGKAIWARHYRKGEEQKPLAYDTEYDFNFQEFKYLEEERTILPGDNIVTQCQYNTKGRTTMTWGGLSTRDEMCLSFLLYYPKINLARCESIPEIKQQLEFIGVKEIYRPVTSWPFIIKSPKKYNNLSFTEAMNAYQWSKKKGNSFNQQALQIPINVRCSKHESNEWMVQ-GMIVSPPQVKEIY--QSEEFVCLSLSS 583          

Query:  243 GIGFSDHGKLENSDLFV--VNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPA---NGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS------------------SVSDVVFENLPEKEFRN--FKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRRS 1760
            G GFS +G + +SD+ +  V   K    D +++    + +D  Q+YLL+  + N         R ++TCD ND  I   T  +I ++  N    +       LN     L+LL       +   +      T   + IP   TTYWC++ ++P L+KKHH++K E +I + ++ +VHH+ L+ C R+  + V  +   C   + P     C  V+ AWA+G   FT+P   G  +G      Y ++EIH++N  +++G+ DNSG+RL+YT  +R+YDAG++E G+  +  + IPP+   F   G+C+ +C  +AL A    GI+VF   LH+HL G  +  RH+RK  E KPL  D  Y  ++QE + L +   +LPGD +VT C Y T  RT +T+GG+   DEMCL+++ YYPKI L  C+S                   V+   F     K++ N  F E  N   WS K      +   + P++  C+  +S+ +      I++P      Y  E+  F CL   S
Sbjct:   63 GFGFSPNGDMASSDIVIGGVEEGKPYLQDFYSDGNRILHRDPHQNYLLEYAMENSTHTILKFSRDLHTCDPNDKTITESTIRVI-WAYHNDDIGHVGPTYHGLNRGRKSLRLLNPEKTYIKSVDTPS-FNFTNKNVPIPYKDTTYWCQMFKMPALNKKHHVVKIEPLIQSGNENLVHHILLYECDRNVNDSVLDYGHECYHPNMPDVFHTCETVVFAWAIGGEGFTFPSHAGLSLGMPTDPKYVLMEIHYDNPSQQEGLTDNSGIRLYYTHHVRKYDAGVLETGIWVSLYHMIPPRMAQFISEGHCTMECLEEALSAENPEGIHVFAVLLHSHLAGKAIWARHYRKGEEQKPLAYDTEYDFNFQEFKYLEEERTILPGDNIVTQCQYNTKGRTTMTWGGLSTRDEMCLSFLLYYPKINLARCESIPEIKQQLEFIGVKEIYRPVTSWPFIIKSPKKYNNLSFTEAMNAYQWSKKKGNSFNQQALQIPINVRCSKHESNEWMVQ-GMIVSPPQVKEIYQSEE--FVCLSLSS 588          

Query:   57 LLHVFIILKIVISYTKPYQYHATYSRTEGVYD------IYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV----NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIE---IPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS-----SVSDVVFENLPEKEFRNFKETFNRVNWSDKNSKLLER 1610
            +  + ++L   IS    +  H  +SR   V        + W V+ + E+I L++      Q     W  +  +    L  SD+ +     +   F   D H +     ++D  QDY L +   N       + RK  TCD  DY  + GT N+   +              F  Y ++LL                    I + +I    IP   TTY C  I LP +  KHHI+KYE  I   S GIVHH+ ++ C      ++    G C      +  + C  V+  WA+G   F YPE  G  IG +    Y  LEIH++N D   GI DNSG+R+FYT +LRQ DAGI+  G+      FIPP  ++F   G C        +P  G   +G+      T     TR    H  +  L  DK Y   +Q+IR  PK +++  GD +V  C   T +R  VT+GG    +EMCL ++FYYP I +  C S      V+D +    PE+   +   + + V+W D+     +R
Sbjct:    7 MWRLGLLLFGSISMGGCWGVHLQFSRVMKVRGRKDSALLRWGVDRHREQIALEV------QVPRASWVALALNLERNLTGSDVVIGGWNGDTEIFYVSDAHIDSQWPPVRDNSQDYELLELRRNETHSTLRVWRKWFTCDPQDYDFEVGTKNLFALT--------------FSIYLIILLNCFGY---------------IILCFIRQFLIPEEDTTYACSFIPLPQVATKHHIVKYEVNIDPQSDGIVHHILIYAC--DANAEIVPEVGDCYGSD--IRYSQCLNVMFGWAVGGEDFFYPEIAGVSIGTKYDPQYVRLEIHYSNFDGISGIRDNSGIRVFYTPELRQLDAGILMAGVLTFPIQFIPPGAEAFRSYGLCDTG----MIPQVGTRGWGATRGLGATRGLGSTRGNGTH--IGSLGEDKSYDFGFQQIRYFPKPIDIKMGDQIVVECTGSTMDRDSVTYGGPSSLNEMCLGFLFYYPNIPIATCWSFYDLNHVTDALGLE-PEESVMDAIFSMDTVDWDDETRAKAQR 496          

Query:   66 VFIILKIVISYTK-------PYQYHATYSRTEGVYDIYWSVEPNLEKIQLKL-CQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV----NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVF------------ENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRRS 1760
            V I L I+++  +       P+ YH      EG+ ++ W+V    E I  +L  Q L     F      G SD G++EN+DL ++    +R  F   D  +++ G+I  D +QDY L       +      +R   TCD  DY I+  T +++   L+        ++   L+  +  +QLL+S +P   +    ++M+I    I IP ++TTYWC + +LP    +HHII YEA+++  ++ +VHHME+F C  +   D  +FNGPC+S+ KP  L  CR V+AAWA+GA AF YP++ G P GG   S +  LE+H++N  + +G  D+SG+RL YT  LR+YDAGI+ELGL YT    IPP++ +F L+GYC++KC++ AL  +GI++F SQLHTHLTG +V T   R  +E K +NRD HY PH+QEIR+L K+V V PGD+L+T+C Y T N+T  T GG  I +EMC+NY+ YYP+ ELELCKS+V D               E +      +  + F+ V W+  N  +L+  YD AP+   CN + +  F G+WN    P + +    LE+ +  C +R++
Sbjct:   30 VAIFLVILVAALRGSEPPESPFPYHIPLD-PEGILELSWNVSYVQEIIHFQLQVQGLRAGVLF------GMSDRGEMENADLIMLWTDGDRAYFA--DAWSDRKGQIHLDSQQDYQLLQAQRTRDGLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQRVQLLKSEVPTPSMPEDVQTMDIRAPDILIPDNETTYWCYITELPPRFPRHHIIMYEAIVTEGNEALVHHMEVFQCA-AESEDFPQFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPKEAGVPFGGPGSSPFLRLEVHYHNPRKIQGRQDSSGIRLHYTATLRRYDAGIMELGLVYTPLMAIPPQETAFVLTGYCTDKCTQMALQDSGIHIFASQLHTHLTGRKVVTVLARDGQERKVVNRDNHYSPHFQEIRMLKKVVTVYPGDVLITSCTYNTENKTLATVGGFGILEEMCVNYVHYYPQTELELCKSAVDDGFLQKYFHMVNRFSSEEVCTCPQASVPQQFSSVPWNSFNRDMLKALYDYAPISMHCNKTSAVRFPGEWNLQPLPKITS---TLEEPTPRCPIRQT 605          

Query:   57 LLHVFIILKIVISYTKPYQY-HATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFV--VNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPA---NGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVV----FENLPE---------------KEFRN--FKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLE 1727
            LL ++ +L    + +    Y H      EG Y ++W  +   E++  +L  + N       + G GFS  G +  +D+ V  V   +    D  TN    + KD +QDY L   + N         R+++TCD ND  +   T  +I     +    +   + D LN     L+LL         +       +  N + IP   TTYWC++ ++P   +KHH+IK E +I    + +VHH+ ++ C  +  + V  F   C   + P     C  VI AW +G   FTYP  VG  +G      Y +LE+H++N   +KG+ID+SGLR+F+T  +R+YDAG+IE GL  +  + IPP    F   G+C+ +C  +AL A   +GI+VF   LH HL G  +  RHFRK  E+K L  D  Y  ++QE + L +   +LPGD L+T C Y T +R  +T+GG+   +EMCL+Y+ YYP++ L  C SS+ D++    F  + E               K++RN  F +  N+  W+ K      +     PV+  C+ +D+  +       I P ++ R Y+ E
Sbjct:    6 LLVLWALLPATAAGSPGRSYPHRVVLDPEGKYWLHWGRQG--ERLAFRLEVRTNG------YVGFGFSPTGSMAAADIVVGGVAHGRPYLQDYFTNADRELEKDAQQDYHLDYAMENSTHTVIEFSRELHTCDVNDKSLTDSTVRVIWAYHHDDPGESGPKYHD-LNRGTRSLRLLNPEKANVVSTVLPYFDLVNQN-VPIPNKGTTYWCQMFKIPTFQEKHHVIKVEPIIERGHENLVHHILVYQCSSNFNDSVLDFGHECYHPNMPDAFLTCETVILAWGIGGEGFTYPPHVGLSLGMPLDPRYVLLEVHYDNPARRKGLIDSSGLRVFHTTDIRRYDAGVIEAGLWVSLFHTIPPGMPEFHSEGHCTLECLEEALGAEKPSGIHVFAVLLHAHLAGKGIRLRHFRKGEEMKLLAYDDDYDFNFQEFQYLREEQTILPGDNLITECRYNTKDRAVMTWGGLSTRNEMCLSYLLYYPRVNLTRC-SSIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYRNLSFMDAMNKFKWTKKEGLSFNKLVLSLPVNVRCSKTDNAEWSIQGMTAIPPDIK-RPYEAE 577          

Query:   99 TKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGF---DLHTNKYGRIIKDERQDY----LLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIII-FSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQ--ALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS-----SVSDVVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEA 1625
            T P +Y      +  V+ + W  +   E I  +L      Q     W G+G +D      SDL V   L        D H      + +D  QD     L +D +    +F     R   TCD +D  I   T  ++  +   +   M+ E H    + F  LLQ+L+     +        ++I+ N+I IP   TTY C  + LP + KKHHI K+E ++   ++ +VHH+ ++ C    GN      G           ++C  VIA WA+G  ++ +P+ VG  IG      +  LEIH++N     GI D SG+RLFYT  LR+YD G+++LG+     +FIPP  ++F   G C      +    P + IY+    LHTHL G  ++   +R   +L+ + +D  Y  + QE R LP  V + PGD L+  C Y+T +R  +TFGG    +EMCL + FYYP+I +  C        V++ + E   E    N     + V W+ +N K  E+   E+
Sbjct:   27 TSPLRYSRFLDPSRAVF-LRWDFDYEAEIITFEL------QVQTTGWVGLGITDRYTFVGSDLVVGGVLPNGNVYFSDQHLLDEDTLEQDGSQDAELLRLTEDAVSTTMRF----SRPFRTCDPHDRDITSDTMRVLAAYGPDDIPKMSRE-HTFVKSIF--LLQMLQYDDQDAPEDTIIHDLKIS-NFI-IPEDDTTYACTFLPLPIVSKKHHIYKFEPILVERNETMVHHVLVYAC----GNSSVLPTGIGECYGSDPAFSLCSHVIAGWAVGGLSYQFPDDVGISIGTPFDPQWIRLEIHYSNFQNLPGIRDTSGMRLFYTSHLRKYDMGVLQLGISVFPIHFIPPGAEAFLSYGLCKTDKFEELNGAPVSDIYISACLLHTHLAGRSLQALQYRNGTQLQVVCKDFSYDFNLQESRDLPHPVVIKPGDELLIECHYQTLDRDFMTFGGASTINEMCLIFFFYYPRINISSCMGYPDIIYVTNELGEEASENPMENLM-VLDNVEWTPENIKKAEKACKES 529          

Query:  651 PASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRF--NGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNN----QDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPK----IELELCKSSVSDVVFENLPEK 1538
            P    TY+C  ++LP +D++  +I ++      S   VHHM LF C          F   G C  ++          ++ AWA  AP    P+ VG  +GGE  S Y +L++H+ +    +D  K   D SG+ L  T   +   AG+    L  +    IPP +K           C  +  P   ++VF  ++HTH  G  V     R + +   + R     P  Q    +   V+V  GDIL   C++    RTE T  G   +DEMC  YI YY +    +    C  +V+  +F  +PE+
Sbjct:   72 PKESDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKAN---------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNHK---DCSGVSLHLTRVPQPLIAGMY---LMMSVNTVIPPGEKVVN----SDISCHYKMYP---MHVFAYRVHTHHLGKVVSGYRVR-NGQWTLIGRQSPQLP--QAFYPVEHPVDVAFGDILAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPEE 348          

Query:  651 PASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRF--NGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNN----QDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPK----IELELCKSSVSDVVFENLPEK 1538
            P    TY+C  ++LP +D++  +I ++      S   VHHM LF C          F   G C  ++          ++ AWA  AP    P+ VG  +GGE  S Y +L++H+ +    +D  K   D SG+ L  T   +   AG+    L  +    IPP +K           C  +  P   ++VF  ++HTH  G  V     R + +   + R     P  Q    +   V+V  GDIL   C++    RTE T  G   +DEMC  YI YY +    +    C  +V+  +F  +PE+
Sbjct:   72 PKESDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKAN---------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNHK---DCSGVSLHLTRVPQPLIAGMY---LMMSVNTVIPPGEKVVN----SDISCHYKMYP---MHVFAYRVHTHHLGKVVSGYRVR-NGQWTLIGRQSPQLP--QAFYPVEHPVDVAFGDILAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPEE 348          

Query:   66 VFIILKIVISYTK-------PYQYHATYSRTEGVYDIYWSVEPNLEKIQLKL-CQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV----NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVF------------ENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRRS 1760
            V I L I+++  +       P+ YH      EG+ ++ W+V    E I  +L  Q L     F      G SD G++EN+DL ++    +R  F   D  +++ G+I  D +QDY L       +      +R   TCD  DY I+  T +++   L+        ++   L+  +  +QLL+S +P   +    ++M+I    I IP ++TTYWC + +LP    +HHII YEA+++  ++ +VHHME+F C  +   D  +FNGPC+S+ KP  L  CR V+AAWA+GA AF YP++ G P GG   S +  LE+H++N  + +G  D+SG+RL YT  LR+YDAGI+ELGL YT    IPP++ +F L+GYC++KC++ AL  +GI++F SQLHTHLTG +V T   R  +E K +NRD HY PH+QEIR+L K+V V PGD+L+T+C Y T N+T  T GG  I +EMC+NY+ YYP+ ELELCKS+V D               E +      +  + F+ V W+  N  +L+  YD AP+   CN + +  F G+WN    P + +    LE+ +  C +R++
Sbjct:   30 VAIFLVILVAALRGSEPPESPFPYHIPLD-PEGILELSWNVSYVQEIIHFQLQVQGLRAGVLF------GMSDRGEMENADLIMLWTDGDRAYFA--DAWSDRKGQIHLDSQQDYQLLQAQRTRDGLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQRVQLLKSEVPTPSMPEDVQTMDIRAPDILIPDNETTYWCYITELPPRFPRHHIIMYEAIVTEGNEALVHHMEVFQCA-AESEDFPQFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPKEAGVPFGGPGSSPFLRLEVHYHNPRKIQGRQDSSGIRLHYTATLRRYDAGIMELGLVYTPLMAIPPQETAFVLTGYCTDKCTQMALQDSGIHIFASQLHTHLTGRKVVTVLARDGQERKVVNRDNHYSPHFQEIRMLKKVVTVYPGDVLITSCTYNTENKTLATVGGFGILEEMCVNYVHYYPQTELELCKSAVDDGFLQKYFHMVNRFSSEEVCTCPQASVPQQFSSVPWNSFNRDMLKALYDYAPISMHCNKTSAVRFPGEWNLQPLPKITS---TLEEPTPRCPIRQT 605          

Query:   27 VYRTEIMRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKL-CQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV--NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKEFR----------------NFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFEC 1745
            +Y T +   +++ V   L+       P+ +H      EG  ++ W++    E I  +L  ++L     F      G SD G+LEN+DL V+  +R      D  +++ G++  D +QDY L       E      +R   TCD NDY I+ GT +++   L+        ++   L+  +  +QLL+ +IP   +   TR+MEI    + IP  QTTYWC V +LP    +HHI+ YE +++  ++ +VHHME+F C  +    +  F+GPC+S+ KP  L  CR V+AAWA+GA AF YPE+ G   GG   S +  LE+H++N     G  D+SG+RL+YT  LR++DAGI+ELGL YT    IPP++ +F L+GYC++KC++ ALPA+GI++F SQLHTHLTG +V T   R  RE + +NRD HY PH+QEIR+L K+V+V PGD+L+T+C Y T +R   T GG  I +EMC+NY+ YYP+ +LELCKS+V          K FR                +  E F  V W+  N ++L+  Y  AP+   CN S +  F+G+WN    P + +R   LE+ +  C
Sbjct:   14 MYGTAVAVFLVILV-AALQGSAPAESPFPFHIPLD-PEGTLELSWNISYAQETIYFQLLVRELKAGVLF------GMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDSQQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSGLHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIVMYEPIVTEGNEALVHHMEVFQCA-AEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMELGLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARDGRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDPGFL----HKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSFNREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSR---LEEPTPHC 589          

Query:   27 VYRTEIMRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKL-CQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGF--DLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGND-VKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVF-------------ENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWN 1682
            +Y T +  + L+ +   L+       P  YH      EG  ++ W+V    E I  +L  ++L     F      G SD G+LEN+DL V+       +  D  +++ G+I  D +QDY L       E      +R   TCD  DY I+ GT +++   L+        ++   L   +  +QLL+  IP  E+     +ME+    I+IP+ +TTYWC + +LP    +HHIIKYE +++  ++ +VHHME+F C  +P  D V  F+GPC+S+ KP  L  CR V+AAWA+GA AF YPE+ G   GG   S Y  LE+H++N    +G  D+SG+RL+YT KLR+++AGI+ELGL YT    IPP++ +F L+GYC++KC++ ALP +GI++F SQLHTHLTG +V T   R  RE + +N+D HY PH+QEIR+L K+V+V PGD+L+T+C Y T +R   T GG  I +EMC+NY+ YYP+ +LELCKS+V D  F             E++      +  + F  V W+  N  +L+  Y  AP+   CN S +  F+G+WN
Sbjct:   21 MYSTAVA-IFLVILVAALQGSAPRESPLPYHIPLD-PEGSLELSWNVSYTQEAIHFQLLVRRLKAGVLF------GMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGNEALVHHMEVFQC--APEMDSVPHFSGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMCVNYVHYYPQTQLELCKSAV-DAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWN 578          

Query:   69 FIILKIVISYTKPYQYHATYS---RTEGVYDIYWSVEPNLEKIQLKL-CQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV---NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVF------------ENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRRS 1760
             +IL   +  ++P +    Y      EG  ++ W+V    E I  +L  ++L     F      G SD G+LEN+DL V+       + G D  +++ G I  D +QDY L       E      +R   TCD  DY I+ GT +++   L+        ++   L+  +  +QLL+  + +  +    R+ME+    + +P  +TTYWC + +LP    +HHI+ YE +++  ++ +VHHME+F C  +      +FNGPC+S+ KP  L  CR V+AAWA+GA AF YPE+ G   GG   S +  LE+H++N  + +G  D+SG+RL+YT  LR++DAGI+ELGL YT    IPP++ +F L+GYC++KC++ ALP +GI++F SQLHTHLTG +V T   R  RE + +NRD HY PH+QEIR+L K+V+V PGD+L+T+C Y T +R   T GG  I +EMC+NY+ YYP+ +LELCKS+V                 E +      +  E F  V W+  N ++L   Y  AP+   CN S +  F+GDWN    P + ++   LE+ +  C   R 
Sbjct:   23 LVILVAALQGSEPPESPFPYRIPLDPEGTLELSWNVSYVQETIHFQLLVRELKAGVLF------GMSDRGELENADLVVLWTDGDSAYFG-DAWSDQKGWIHLDAQQDYQLLRAQRTPEGLSLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFWSLEAINTSALHTGLQRVQLLKPNVSVPALPADMRTMEVRAPDVLVPGQETTYWCYITELPDGFPRHHIVMYEPIVTEGNEALVHHMEVFQCA-AEFESFPQFNGPCDSKMKPSRLNYCRNVLAAWALGAKAFYYPEEAGLAFGGAGSSRFLRLEVHYHNPLKIEGRRDSSGIRLYYTATLRRFDAGIMELGLVYTPVMAIPPQETAFVLTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLARDGREREVVNRDDHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRKLATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDPGFLQKYFHFVNRFNGEEVCTCPQASVPEQFATVPWNSFNRQVLSALYGFAPISMHCNRSSAVRFQGDWNLQPLPEIISK---LEEPTPRCPASRG 594          

Query:  102 KPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGI--GFSDHGKLENSDLFVV----NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVF------------ENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRRS 1760
             P+ YH      EG  ++ W+V  + E I  +L      Q   P  +G+  G SD G++EN+DL ++    +R  F   D  +++ G+I  D  QDY L              +R   TCD  DY I+  T +++   L+        ++   L+  +  +QLL+  +    +    ++M+I    + IP+++TTYWC + +LP    +HHII YEA+++  ++ +VHHME+F C          FNGPC+S+ KP  L  CR V+AAWA+GA AF YPE+ G P+G    S +  LE+H++N    +G  D+SG+RL YT  LR  +AGI+ELGL YT    IPP++ +F L+GYC+++C++ ALP +GI +F SQLHTHLTG +V T   R  ++ + +NRD HY PH+QEIR+L   V V  GD+L+T+C Y T NRT  T GG  I +EMC+NY+ YYPK ELELCKS+V D               E +      +  + F  V W+  N  +L+  Y+ AP+   CN + +  F G+WN    P + +    +E+    C +R++
Sbjct:   48 SPFPYHIPLD-PEGTLELSWNVSYDQEIIHFQL------QVQGP-RAGVLFGMSDRGEMENADLVMLWTDGDRTYFA--DAWSDQKGQIHLDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQQVQLLKPEVSTPAMPADVQTMDIRAPDVLIPSTETTYWCYITELPLHFPRHHIIMYEAIVTEGNEALVHHMEVFQCTNE-SEAFPMFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPLGSSGSSRFLRLEVHYHNPRNIQGRRDSSGIRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGYCTDRCTQMALPKSGIRIFASQLHTHLTGRKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAVTVHQGDVLITSCTYNTENRTMATVGGFGILEEMCVNYVHYYPKTELELCKSAVDDGFLQKYFHIVNRFGNEEVCTCPQASVPQQFASVPWNSFNRDMLKALYNYAPISVHCNKTSAVRFPGNWNLQPLPNITSA---VEEPDPRCPIRQT 604          

Query:  195 KLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFG 1421
            KLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLRSTIPISEISPSTRSMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCI SPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQK FALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQE+RLLPKIVNVLPGD LVTTCIYKTTNRTEVTFG
Sbjct:    1 KLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLRSTIPISEISPSTRSMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCISSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKGFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEVRLLPKIVNVLPGDTLVTTCIYKTTNRTEVTFG 409          

Query:   45 MRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKF-LGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKE-FRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDW 1679
            MRLIL + FI + I+ISY   +QYH TYS  E +Y I WS++ + E IQL++C+K      FP W GIGFS+ GK+EN+DLF VN +KF  GFDLHTN YG II+D   +Y LKD   +H+  CF   RK+NTCDK DYQIDRGTTNIII S K  +N+N+   ++ LNYFV+ LQL+RS IPIS IS ST+ M+I VN I+IP S+TTYWCK+I+LP L++KHHIIKYEA++   S+G+VHHMELFHC   P + +K +N PCN+ESKPMGLTMCRK           FTYPE+VGNPIGGE FS YAILEIH+NN +EK+GIIDNSGLRL+YTD+LRQYDAGIIELGLEYTEKN IPPKQ SF LSGYC ++C++QALP NGI+VFGSQLHTHLTG+QVETRHFR  +EL+PLN D HYQPHYQEIRLLPKIVN+LPGD+L+TTC Y T NR+E+TFGGIEIT+EMCLNYIFYYP+I+LELCKSSV+D + E   EK+   N K  FN + WS  NSKLLERFY+ AP+HQSCNMSDS SFEG W
Sbjct:    1 MRLILFNNFISINILISYCYNFQYHTTYSENENIYHIDWSIDTHFENIQLQICEKFKNSIDFPNWLGIGFSNRGKIENADLFAVN-IKFEKGFDLHTNSYGEIIEDNENNYHLKDIFTSHKNVCFIFDRKLNTCDKFDYQIDRGTTNIIILSSK-FENINH-FGLELLNYFVIQLQLIRSRIPISPISSSTQFMDIQVNNIKIPDSKTTYWCKLIKLPRLEQKHHIIKYEAILK--SRGLVHHMELFHCEVPPDDSMKYYNAPCNAESKPMGLTMCRK----------PFTYPEEVGNPIGGEKFSNYAILEIHYNNPEEKRGIIDNSGLRLYYTDELRQYDAGIIELGLEYTEKNSIPPKQTSFILSGYCLDECTKQALPTNGIFVFGSQLHTHLTGVQVETRHFRNDKELEPLNIDTHYQPHYQEIRLLPKIVNILPGDMLITTCTYNTLNRSEMTFGGIEITNEMCLNYIFYYPRIKLELCKSSVNDFILEQFFEKKPTENLKNIFNNIKWSKNNSKLLERFYELAPIHQSCNMSDSKSFEGHW 532          

Query:   66 VFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV---NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSV-SDVV---------FENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITP 1697
            V++++       + YQY  T    +  Y   WSV+     I ++L  K+  +     W   GFSD+G + ++DL +       K   FD HT   G  + D +QDY L     +         R  NTCD  DY +D GTT+++       +       V  L + V  LQLL+  I        T S E+    + +PA +TTYW     LP +   HHII+YE +++  S  +VHHME+FHC    G+ V  +NGP  +E KP GL +CRKVI AWAMGA A  YPE+ G P+GG+ FS +A+LE+H+NN  +K G +D+SG+R   T +LR+YDAGI+ELGLEY  K  +PP Q+ F LSGYC  KC++ +LP  GI+VF SQLHTHLTG +V T+H R   EL  +NRD HY PH+QEIR LP+  +VLPGD+L+TTC Y TT R++ T GG  ITDEMCLNY+ YYP+ +LE+CKSSV +D +         FEN         +  +  + WS  N +LLE  Y  +P+   CN SD   F G+W  +  P
Sbjct:   12 VWLVVLSADHSVQAYQYQVTLD-PDSRYLFQWSVDYKESLINVQLTCKVTPE----SWLAFGFSDYGDVTSADLILFWTDGDGKHHFFDGHTTPDGIFLPDRQQDYHLTSVADDRGSVVLDFYRHFNTCDPEDYALDNGTTHLVYVESAQPEGPPLARDVTRLRHGVQRLQLLKPEISAPVFPEDTWSFEVRAPEVLVPAEETTYWWHTTILPDMPSPHHIIQYEGIVAEGSGDLVHHMEVFHCQVQKGHGVPYYNGPGIAEGKPEGLEVCRKVIGAWAMGAEAMIYPEEAGVPVGGQGFSRFALLEVHYNNPQKKSGRMDSSGIRFHVTSQLRKYDAGIMELGLEYVNKMAVPPGQRDFKLSGYCVHKCTQMSLPPAGIHVFASQLHTHLTGRRVYTKHARDGAELPEVNRDNHYSPHFQEIRRLPQPHHVLPGDVLITTCEYDTTKRSKATVGGFSITDEMCLNYVHYYPRSDLEVCKSSVRTDSLHTFFFLLNRFENSKVSPEAGDRANYESIEWSPLNVRLLEDLYSTSPLSMQCNRSDGTRFPGEWEHVRVP 563          

Query:   66 VFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV---NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSV-SDVV---------FENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITP 1697
            V++++       + YQY  T    +  Y   WSV+     I ++L  K+  +     W   GFSD+G + ++DL +       K   FD HT   G  + D +QDY L     +         R  NTCD  DY +D GTT+++       +       V  L + V  LQLL+  I        T S E+    + +PA +TTYW     LP +   HHII+YE +++  S  +VHHME+FHC    G+ V  +NGP  +E KP GL +CRKVI AWAMGA A  YPE+ G P+GG+ FS +A+LE+H+NN  +K G +D+SG+R   T +LR+YDAGI+ELGLEY  K  +PP Q+ F LSGYC  KC++ +LP  GI+VF SQLHTHLTG +V T+H R   EL  +NRD HY PH+QEIR LP+  +VLPGD+L+TTC Y TT R++ T GG  ITDEMCLNY+ YYP+ +LE+CKSSV +D +         FEN         +  +  + WS  N +LLE  Y  +P+   CN SD   F G+W  +  P
Sbjct:   12 VWLVVLSADHSVQAYQYQVTLD-PDSRYLFQWSVDYKESLINVQLTCKVTPE----SWLAFGFSDYGDVTSADLILFWTDGDGKHHFFDGHTTPDGIFLPDRQQDYHLTSVADDRGSVVLDFYRHFNTCDPEDYALDNGTTHLVYVESAQPEGPPLARDVTRLRHGVQRLQLLKPEISAPVFPEDTWSFEVRAPEVLVPAEETTYWWHTTILPDMPSPHHIIQYEGIVAEGSGDLVHHMEVFHCQVQKGHGVPYYNGPGIAEGKPEGLEVCRKVIGAWAMGAEAMIYPEEAGVPVGGQGFSRFALLEVHYNNPQKKSGRMDSSGIRFHVTSQLRKYDAGIMELGLEYVNKMAVPPGQRDFKLSGYCVHKCTQMSLPPAGIHVFASQLHTHLTGRRVYTKHARDGAELPEVNRDNHYSPHFQEIRRLPQPHHVLPGDVLITTCEYDTTKRSKATVGGFSITDEMCLNYVHYYPRSDLEVCKSSVRTDSLHTFFFLLNRFENSKVSPEAGDRANYESIEWSPLNVRLLEDLYSTSPLSMQCNRSDGTRFPGEWEHVRVP 563          

Query:   57 LLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVV---NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENL--------PEKEFRNFKETFNRV--NWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDW-----NAIITPILETRDYD 1721
            ++   +I K+V  +   +QY   +  + G Y   WSV+     + +++  K+ +     IW  +GFSD+G + ++DL V            D +TN +G I+ D++QDY L     +H        R+ NTCD+ DY +D GTT++I F       +     V  L + V  +QLL+  +P+  +   T + E+    I IP+ +TTYW     LP +   HHI+KY  VIS  ++ +VHHME+FHC    G  +  ++GP  +E  P GL  CR+VIAAWAMGA    YPE+ G  IGG++ S +A+LE+H+NN + K G +DNSG+R + T +LR+ +AGI+ELGLEY  K  IPP QK F LSGYC + C+R  LP  GIYVF SQLHTHLTG ++ T+H R+  EL  LNRD H+ PH+QEIR LP+  NVLPGD LVTTC Y T +R + T GG  ITDEMC+NYI YYP+ ELE+CKSS+     +            K + +  +  N V  NW+  N++LL+  Y  +P+   CN SD   F GDW     + I  P++  RD D
Sbjct:   11 IIGCLLIFKMV-KWASAFQY-KLHLDSNGRYLFEWSVDYQKNNVNVQITAKVTQD----IWFAVGFSDYGSVTSADLVVFWTDGHGNHHFVDGYTNDHGIILPDDQQDYFLTSVAADHGAVVLDFYRRFNTCDEQDYTLDNGTTHVIFFESVYANELPFGHVVSSLGHAVKRVQLLKPELPMPVLPNDTWTFEVRAPEILIPSVETTYWWHTTILPRIPTNHHIVKYSGVISEGNEDLVHHMEVFHCQVPKGQKIPYYSGPAENEDTPKGLEPCRRVIAAWAMGAQDMVYPEEAGVSIGGQDTSRFALLEVHYNNPERKSGRMDNSGIRFYVTSQLRKNEAGIMELGLEYINKMAIPPGQKKFKLSGYCVQDCTRVGLPPGGIYVFASQLHTHLTGRRLYTKHVRQGLELPELNRDNHFSPHFQEIRRLPQPHNVLPGDELVTTCEYDTRSRDKATIGGFSITDEMCVNYIHYYPRTELEVCKSSIQTNALQTFFFLLNRLEDAKVYPDAGDRANYVNINWTPVNAQLLDELYATSPLSMQCNRSDGVRFPGDWEHQKVSEIAQPLV-ARDMD 576          

Query:  246 IGFSDHGKLENSDLFVV---NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVS-DVV--FENLPEKEF----------RNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITP-ILETRDYDLEKQSFECLMRRS 1760
            IG SD G+  N+DL ++       + G D  ++  GR++ D +QDY L +       F    +R  +TCD +DY I+ GT ++I   L        +L+V  L+  V  + LLR   P   +    +S+E+    I IP+ +TTYWC + QLP    K+HI+ YE+V+++ ++ I                   ++G C+S+ KP  L  CR V+AAWA+GA  F YP   G PIGGE  S +  LE+H++N     G  D+SG+RL+YT  LR++DAGI+ELGL YT    IPP+Q SF LSGYC   C+R ALP  GI++F SQLHTHL G  V T   R  +E++ +  DKHY  HYQ          VL GD LVT C + T +R + T GG  I +EMC+NY+ YYP+ +LELCKS V  D +  + +L    F          R+ +E F+ V+W   + ++L   Y  +P+   CN S ++ F G+W     P +LE    +L+++ + C + RS
Sbjct:   85 IGLSDRGQPTNADLVLLWSDGHKSYFG-DAWSDAEGRVMLDSQQDYQLLEAQNTPTGFTVLFRRPFSTCDPHDYVIEEGTVHVIYALLDQPIRSLQQLNVSRLHTGVQRILLLRPDTPAPSLPADVQSIEVLAPGITIPSQETTYWCHIYQLPANMPKNHIVMYESVVTSGNEAI-------------------YSGSCDSKMKPANLNYCRHVLAAWALGAEPFYYPMDAGLPIGGEGSSRFLRLEVHYHNPLIISGRQDSSGIRLWYTRSLRRFDAGIMELGLVYTPVMAIPPRQSSFPLSGYCIPACTRTALPQGGIHIFASQLHTHLAGRTVRTVLVRGGKEVEVVQEDKHYSTHYQ----------VLHGDALVTKCTFNTEDRNKPTVGGFGIMEEMCVNYVHYYPRTQLELCKSHVDLDYLKKYFSLINSRFHGGEGCSCSQRSVEEEFSSVSWDQFSEEVLNSLYTTSPISMHCNQSTAELFPGNWEKQKIPEVLE----ELQREPYPCELGRS 572          

Query:  117 HATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLF---VVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPA---NGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELC------------------KSSVSDVVFENLPEKEFRN--FKETFNRVNWSDKNSKLLERFYDEAPVHQSCN 1646
            H+      G Y + WS +      +++   +         + G+GFS +G + ++DL    V N + +L  D + +    + KD  Q+Y L     NH        R + TCD ND  I  G+T  +I++L ++    +      +N     L+ L      +  +     M++  N + +P   TTYWC++ ++P + +KHHII+ E +I    + +VHH+ L+ C  S           C   + P   T C  VI AWA+G   FTYP  VG  IG +    Y ++E+HF+N   +  ++D+SGLRLFYT KLR YDAG+IE G+  +  + +PP  + F   G+C+++C +++L +   +G+ VF + LH HL G  + TRHFR+  EL P+  D  +  ++QE + L     +LPGD L+T C+Y T  R  +T+GG+   +EMCL+Y+ YYP++ L  C                  +S ++   F     K + N  F E  ++  W+ K  K         P++  C+
Sbjct:   56 HSAALDAGGRYALKWSFDETSITFEVEAATR--------GYMGLGFSPNGAMASADLVIGGVANGIPYL-HDYYADSSRVVHKDPVQNYRLLYGRENHTHTVLGFSRDLETCDPNDRAIT-GSTMRVIWALHSEDVGPSGPVYHGINRGRKSLRFLNPGTNRNVPAGIAT-MDLRNNNVPVPDKDTTYWCQMYKMPDVQQKHHIIRIEPLIQKGHENLVHHILLYQCDSSLNESELDLGHNCFHPNMPDSFTTCETVIFAWAIGGEGFTYPPHVGMSIGTDIDPVYVLMEMHFDNPALQTDVVDSSGLRLFYTPKLRTYDAGVIETGVWVSLYHMLPPGMEDFITEGHCTQECLQESLESEMPSGVSVFAALLHAHLAGRAIRTRHFRQQVELPPMALDDQFDFNFQEFQPLSPERQILPGDSLITECVYNTKGRNNMTWGGLSTRNEMCLSYLLYYPRVNLARCESLPEIRGQLKFIGVKQIQSPLTTWPFMIKSPKRYSNLSFTEAMDKFRWTKKRGKAFNEVVLNLPMNVRCS 580          

Query:  237 WSGIGFSDHGKLENSDLFV--VNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMN------NELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPC-NSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQAL--PANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS 1499
            W G GFS +G +E +D+ +  V        D H       + DE+QDY L        Q     +R +  CDK+DY I      +I ++     N+           V+ L +                + P +   ++T+  + IP   T Y CKV+++P LD+K+H+ + E +I   +  +VHH+ L+ C   P          C   E++    T C + +AAW +G  AF  PE  G P+GG++  T   LE+H+NNQD   G +DNSGLR +YT +LRQYDA ++  GL       IPP   +F   G C      Q +  P   ++VF   LHTHL G ++   HFR   ++  L  D+HY   +Q+   L K   +  GD L+  C Y T NRT +T GG+  T+EMCL ++FYYP + L  C S
Sbjct:   62 WVGFGFSPNGGMEGADIVIGGVGPDGIYFTDRHAVGKFMPLLDEQQDYRLLSLTEADGQTVMKFERLIRACDKDDYPITEVPVKLI-YAYGKTDNITYHRTSRGTKEVNLLKFM------------PKAMLPDSNYFDLTMTNLTIPTENTYYHCKVMKIPLLDQKYHVYRIEPLIE--NMDLVHHLLLYRC---PPTVTTPTEEACYTGETQ----TQCFQTVAAWGVGGGAFELPEVAGIPVGGDDGKTLYRLEVHYNNQDNIAGRVDNSGLRFYYTSQLRQYDAAVLMTGLAVVPGYVIPPNTTNFHSYGVCDTSQVSQVISDPKADLHVFSVILHTHLAGRKIRVGHFRNGEQIDLLAMDEHYNFEFQQAVNLGKTKTIKLGDQLLVECTYNTENRTGLTLGGLATTNEMCLAFLFYYPAMSLSSCVS 471          

Query:  237 WSGIGFSDHGKLENSDLFV--VNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMN------NELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPC-NSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS 1499
            W G GFS +G +E +D+ +  V        D H       + DE+QDY L        Q     +R +  CDK+DY I      +I ++     N+           V+ L +                + P +   ++T+  + IP   T Y CKV+++P LD+K+H+ + E +I   +  +VHH+ L+ C   P          C   E++    T C + +AAW +G  AF  PE  G P+GG++  T   LE+H+NNQD   G +DNSGLR +YT +LRQYDA ++  GL       IPP   +F   G C +     + P   ++VF   LHTHL G ++   HFR   ++  L  D+HY   +Q+   L K   +  GD L+  C Y T NRT +T GG+  T+EMCL ++FYYP + L  C S
Sbjct:   68 WVGFGFSPNGGMEGADIVIGGVGPDGIYFTDRHAVGKFMPLLDEQQDYRLLSLTEADGQTVMKFERLIRACDKDDYPITVMPVKLI-YAYGKTDNITYHRTSRGTKEVNLLKFM------------PKAMLPDSNYFDLTMTNLTIPTENTYYHCKVMKIPLLDQKYHVYRIEPLIE--NMDLVHHLLLYRC---PPTVTTPTEEACYTGETQ----TQCFQTVAAWGVGGGAFELPEVAGIPVGGDDGKTLYRLEVHYNNQDNIAGRVDNSGLRFYYTSQLRQYDAAVLMTGLAVVPGYVIPPNTTNFHSYGVC-DTSQVISDPKADLHVFSVILHTHLAGRKIRVGHFRNGEQIDLLAMDEHYNFEFQQAVNLGKTKTIKLGDQLLVECTYNTENRTGLTLGGLATTNEMCLAFLFYYPAMSLSSCVS 474          

Query:  648 IPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGN-----DVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHF----NNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYP----KIELELCKSSVSDVVFENLP 1532
            +P++  +Y+C  + +P    + +I+ +   +   S    HHM L+ C R+P +     D  R  G C  E+K         ++ AWA  AP    P+ VG  +GG+   TY +L+IH+    N +D  K   D SGL L  T K + + AG+    L  +    IPP +            C+  + P   +Y F  + HTH  G  V     R + +   + R     P  Q    +   + V  GD L   C++    R+  T  G    DEMC  Y+ YY      I    C    S  +F ++P
Sbjct:   68 VPSASDSYYCVAVPVP-TSWEAYIVDF---VPHASMDTAHHMLLYGC-RNPTSTKGYWDCGREQGTCEDEAK---------IMYAWARNAPPTKLPKDVGFKVGGDTRITYFVLQIHYGDIKNFRDHHK---DCSGLTLRMTSKPQPFIAGMY---LMMSVDTVIPPGKTVTN----ADIACTYLSYP---MYPFAFRTHTHRLGKVVSGYRIR-NGQWTLIGRQSPQLP--QAFYPVSNDIEVKYGDTLAARCVFTGEGRSSKTRIGGTSNDEMCNFYMMYYMDNKHSIPYMDCMDHGSSSLFRSIP 345          

Query:  237 WSGIGFSDHGKLENSDLFV--VNRLKFLGF-DLHTNKYGRIIKDERQDY---LLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNII-IFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNY--IEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMC-RKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCS------RQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTF--GGIEITDEMCLNYIFYYPKIELELCKS 1499
            W  +GFS  G +  SD+ +  V+      F D H      +++D  QDY    L++N  +       +QR + TCD +D +++  T  ++  +  K+  +  +  +        + +QLL    P  +  PS  +    VNY   EIPA  T Y C++  +P LD+KHH+IK    + A ++  VHH+ L+ C  S        +  CN  + P   T C   ++A WA+G   F YP + G  +G +    + +LE H++N  +  G+ D+SGLR + T +LR YD+G++E+G+     +FIPP   SF  S Y  E+ S       QA  +  I VF + LH HL G  ++ RHFR+ +++  L RD  Y  +YQE R L ++  VLPGD L+T C Y++T+R+  T    G+   DEMC+ +++YYP++ +  C S
Sbjct:   21 WVAVGFSPTGSMAGSDVALGWVDGTGAAHFMDGHVIDR-EVLRDGSQDYSAVWLRENGTHTH---MRLQRPLRTCDSHDMELNEDTIRVVWAYGAKDPASEADIPYHGPTTRGSMSVQLLGHGPPSEQPLPSNHA-HFDVNYDKFEIPAQSTFYQCEIFPVPKLDRKHHLIKVVPRLQANNEAFVHHILLYTCSASVNASHVGASHECNHPNMPDSFTHCFGGIMAGWAVGGGTFDYPPEAGFSLGAQGDPQFVMLETHYDNPAQLAGVADSSGLRFYITPELRAYDSGMLEVGVNPQPTHFIPPMTPSFMRSIYGHERVSLCPCGHTQARQSGEIQVFATILHAHLLGAAMQVRHFRQGKQIGHLGRDMGYDFNYQEARYLKELTAVLPGDELITECTYRSTSRSHTTTFKVGLSTQDEMCIAFLYYYPRVNVSRCLS 454          

Query:  648 IPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQ-LHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS 1499
            IP   T Y CK+ QLP LDKKHH+IK + VI A ++  VHH+ ++ C+ +           C   S       C+ V+AAWA+G   F YP   G  +G +    + +L++H++N        D+SG R +YT +LR Y+AG++E G+    ++FIPP    F   G C+ K    +   + + V   + LHTHL GI V+ RHFR   ++  L RD  Y   +QE R L K+ +VLPGD ++T CIY T  R   T GG+   DEMCL++ +YYPK+ + +C+S
Sbjct:   10 IPTVATYYSCKLFQLPKLDKKHHLIKVKPVIQAGNERYVHHLLVYVCLNTLNVSYVGSQAECYKYSSTHPFATCKTVMAAWAVGGETFDYPANAGFSLGLDEDPQFLLLQMHYDNAGLVSRANDSSGFRFYYTPELRTYEAGLLETGIFAYSQHFIPPNTARFTSYGICNTKTFYTSNANSTLQVLAVRFLHTHLAGISVQARHFRNGTQIGNLGRDMGYDFDFQETRYLNKLTSVLPGDQIITECIYNTAGRNTTTAGGLGTMDEMCLSFFYYYPKVNVGICRS 294          

Query:  648 IPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLT-----MCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKG----IIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKC--------SRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS-----SVSDVVFENL----------PEKEFRNFK-ETFNRVNWS 1583
            IP  +T Y C V+QLP L KKHH+IK + ++ A +   VHHM ++ C  +           C S    MG T      C  V+AAWA+G   F YP   G  +G +      +LE+H+NN     G    + D+SGLRL+YT  LR+YD GI+E G+     +FIPPK  SF   G C+ +         + Q   +  + VF + LH+HL GI ++ RHFR   ++  L RD  Y    QE R L  +  VLPGD +VT C Y+TT RT  T GG+   +EMCL++++YYPK+ + LC+S     +V+ V+   L          P+  FR F  E ++ + W+
Sbjct:    1 IPPVETNYVCNVMQLPNLTKKHHLIKVQPLVQAGNTRFVHHMIVYACETNVNMSYINTTFQCYSS---MGATNHPSARCLSVLAAWAVGGETFDYPADAGYSLGMDADPKVVMLEMHYNNPQAASGTHTGVSDSSGLRLYYTPNLRKYDTGILETGILPNIYHFIPPKTTSFTSYGICNTRSFVTANSNDTLQGQVSGTMNVFATMLHSHLAGIAIQVRHFRNGNQIGNLGRDMGYDFGLQETRYLNNLTAVLPGDQVVTECTYRTTTRTVTTTGGLSTMNEMCLSFLYYYPKVNIGLCRSMYDITTVAPVMGFTLNSQWPYYITSPQAFFRYFLFEIYDVIPWT 342          

Query:  723 KYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPA---NGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVT-FGGIEITDEMCLNYIFYYPKIELELCKS 1499
            + E ++    +G+VHH+ L+ C       + +    C   + P     C  ++ AWA+G  AF YP  VG  +G      + ++E H++N  +  GI DNSGLRL YT +LR YDAG++E G+  +  + +PP    +   G+C+ +C  +AL      G+ VF   LH HL G ++  RH+R  REL  L RD  Y  ++QE+ +LP    +LPGD L T C+Y T  R  +T +GG    +EMCL Y+ YYP++ L  C+S
Sbjct:    1 QVEPLVKPGHEGMVHHILLYQCALGLHEAILQSGHRCYQANMPEEFRSCESILFAWAIGGGAFLYPPHVGLSLGEPGDPVFVLMETHYDNPLQLSGIRDNSGLRLHYTAQLRAYDAGVMETGVWVSLYHMVPPHAPHWVSQGHCTRECLNEALGTERPQGVSVFAVLLHAHLAGRELLVRHWRGDRELPLLARDSEYDFNFQELHMLPSERLLLPGDHLTTECVYNTEGRVNMTWWGGQSTHNEMCLAYVLYYPRVNLSRCQS 263          

Query:  237 WSGIGFSDHGKLENSDLFV--VNRLKFLGF-DLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDF---LNYFVVLLQLLXXXXXXXXXX-XXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFN--NQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQ---ALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNR 1403
            W G+G S  G +  SD+ V  V+        D H      +++D  QDY L     N       + R + TCD ND  I   T  +I  S  N  +  +E  + +   ++     LQLL S             + +I  +   IP   T Y CK+  LP L KKHH+++ E +I   S+ +VHHM ++ C  +           C     P   + C  V+AAWA+G   F YP   G  +G      + +LEIH+N  N+    GI D+SGLR  YT +LR++DAG +  G+  +  +FIPP   SF    +C   C            +  F S + +H  G  +    F    ++  + R++ Y   +QE R L K+V VLPGD +V  C+Y+TTNR
Sbjct:   38 WVGLGLSSTGTMAGSDVVVGWVDSAAATHLVDAHIEGERSLVRDTSQDYKLVRLSENGTHTVMRVVRALRTCDANDRDITENTMRLIWASEDN--DPKSEAQITYHGPMDRGTKSLQLLSSRPRSQPELPQDRSTFDIVQDKCAIPPDSTFYACKIFSLPNLSKKHHLVEVEPIIDPGSEALVHHMVVYMCPDTVNASHVGVTHQCYLAQLPDSFSTCTSVLAAWAIGGGTFEYPPAAGYSLGVPGDPRFVLLEIHYNNPNRSTAAGIEDSSGLRFHYTAQLRRFDAGHLMAGIIVSPFHFIPPNTDSFLNLYHCPSACGNNRWGCYTGQRVRFFSSFVLSHFIGGAIFFTPFENGTQIGDVGREQDYDFKFQETRHLKKLVTVLPGDKIVVECVYRTTNR 436          

Query:  153 IYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDL---FVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNII-IFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESK-PMGLTMCRK---VIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQ---ALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKI 1478
            +YWS+  N + I   L  +      F I SG G      ++ +D+   +V +   FL       +Y   I D+  DY L      + +      RK++TCD  D +I  GTT +I     ++ Q+ N+     F     VL+  L S    +   P+    +I +N   +PA  TTY C V  +P   KKHHI++++ V+ + + GIVHH  +  C +     +      C  E+  P  +  CR    ++ AW +G   F YP+ VG+P+G +    Y ++E+H+NN D+  G IDNSG+R FYTD LR+YDAG++ +G   T    IPPKQK +  + YC+++C+        +  I  F + LHTHL G    T+H R   EL  + RD +Y  ++Q+I+ L K V+ LPGD L+  C+Y T +RT VTFGG    DEMCLN++FYYP I
Sbjct:   39 LYWSINHNAKTISFALEAETTGWVGFGISSGSGM-----MKGADIVIGWVKDGKAFLTDRYADGEYMPKI-DDHNDYKLISGTEENGKTILKFSRKIDTCDPRDRKIKIGTTKVIWALDYEDPQSENDMRKHRFRGSRSVLM--LNSQGNSNPPDPAWSHFDILMNNYTVPARHTTYSCHVFTIPKFTKKHHIVRFDPVVQSENAGIVHHFIVMACDKDFPEHLSNDTSECTDEANMPAEVLKCRGRGVLVGAWGVGGGPFVYPDHVGSPLGLDFQGRYFVMEVHYNNPDKLAGKIDNSGVRFFYTDSLRKYDAGVLNVGASVTPWMLIPPKQKEWTTTTYCNKRCNENVSVTQKSRRIKFFSAFLHTHLAGRATWTKHVRNGVELPEIARDDNYDFNFQDIQFLNKEVHFLPGDELIHECVYNTMDRTGVTFGGEATNDEMCLNFMFYYPFI 483          

Query:  153 IYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGF--DLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVV---LLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRS-PGNDVKRFNGPCNSESKPMGLTMCRKV--IAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSR-QALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELC 1493
            +YW+V  +   ++  L  +      F I +G G      +  SD+ +       G+  D + +       D  QD+ L ++   +     +  RK  TCD  D +I+ G+  ++ +S  + ++ +      FL +       L LL       ++       ++  N + IP+  T+Y CK  + P    KHHI+KY  +I++ + G VHHM ++ C  S P +++    G C  ++ P  +  C     IAAWA+G   F YPE VG   G  +   Y +LEIH++N     G+ D+SG+R F+T+K RQ+DAGI+  G        IPP+Q+ +   GYC   C+R  +LP  GI +F    HTHL GI+V TRH R  +EL  + R++HY  +YQE ++L   V+V PGD ++  C Y+T N+     GG+  T+EMC++++ YYP+++L  C
Sbjct:    9 LYWNVNHDESSVKFALRVQATGWVGFGISAGTG-----NMVGSDVVMGWVKDGKGYLQDRYADSKSLPSLDSSQDWHLLESSEENGFTTLSFHRKFYTCDTKDNKIEDGSVRVV-YSYHDTKDPDISDDSTFLYHSARGSRTLILLNVHKKKPQLPAQLSHFDLRHN-LTIPSRLTSYMCKPFEFPQPASKHHIVKYMPLINSKNLGRVHHMLVYGCHSSFPRSNLSHV-GECTDKNMPPAIQRCSGAAPIAAWAIGGEDFYYPEHVGLAFGDGHGPRYVVLEIHYDNPQNDLGVYDDSGIRFFFTNKTRQFDAGILWAGWAPISAMVIPPRQEEWTSIGYCPSNCTRLSSLPDKGINIFAGMEHTHLQGIKVWTRHVRDGKELPEIIREEHYDFNYQEFQVLRNEVHVKPGDDIIQMCKYQTKNKNYPVVGGLGTTEEMCMSFLLYYPQVDLAKC 456          

Query:  720 IKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPC-NSESKPMGLTMC--RKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKC-----SRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDV 1514
            ++ E +++  ++G VHH  ++ C  +   ++    GPC +  + P  +T C  +  + AWA+GA  F YP+ VG  IG  +   Y ++E+H++N    +G+ D SGLR  +T + R YDAG+I  G    +   IPP+QK +   GYCS +C     ++  LP  GI +    LHTHL G+++ TRH R   EL  + RD +Y  ++QE ++LP+ V+V PGD LV  C Y+T ++TE   GG+   +EMC+ +I YYPK+EL  C  SV+DV
Sbjct:    5 LQVEPIVTPGNEGYVHHTVVYGCKSTFNPNLTTVTGPCYDRINMPPDITSCAGQSSLWAWAVGAGPFFYPKHVGFAIGAGHGPRYVVMEVHYDNPSNTEGVADYSGLRFHHTAQTRMYDAGMIWAGWAPFDAMIIPPQQKEWISVGYCSGECTEAGFAQSTLPDKGINIIAILLHTHLQGVKIWTRHIRDGVELLEVARDDNYDFNFQEFQVLPEEVHVKPGDDLVQVCHYQTMDKTEPVVGGLGTPEEMCMAFIVYYPKVELTKCW-SVNDV 276          

Query:  726 YEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNS---ESKPMGLTMCR---KVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQ-----ALPANGIYVFGSQLHTHLTG---IQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPK 1475
            +E  +   ++G VHH  +F C   P  +V   N   +       P  +  C+   ++ AAW +G  AF YP+ VG PIG ++  +  ++E+H++N ++  G  D+SG+R +YTDKLR YD+G   +G        +PPKQ+ +   G+C  +C++Q      LP  GI VF S LHTHL G   + +   H R    L P           QEI+ LP   ++ PGD ++  C Y T +R +  FGG    DEMC+N++ YYP+
Sbjct:    1 FEPAVVPGNEGFVHHFVVFEC--HPRFNVSHLNYTMDCLDFVKMPQEIQTCKTLGEITAAWGVGGGAFVYPDHVGYPIGMQDSGSILVMEVHYDNPEKLTGRFDSSGVRFYYTDKLRLYDSGTWSVGDSVNTWMMVPPKQEEWISEGHCPHQCTKQLLENTTLPEKGINVFASFLHTHLAGKATVMLCVFHVRFLPTLLP-----------QEIQALPLERHIRPGDDVIHYCKYNTMDRQKTVFGGFGTKDEMCINFMLYYPR 251          

Query:  720 IKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSE-SKPMGLTMC--RKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKC-----SRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNR 1403
            ++ E +++  ++G VHH  ++ C  +   ++    GPC    + P  +T C  +  + AWA+GA  F YP+ VG  IG  +   Y ++E+H++N    +G+ D SGLR  +T + R YDAG+I  G    +   IPP+QK +   GYCS +C     ++  LP  GI +    LHTHL G+++ TRH R   EL  + RD +Y  ++QE ++LP+ V++ PGD LV  C Y+T ++
Sbjct:    5 LQVEPIVTPGNEGYVHHTVVYGCKSTFNPNLTTVTGPCYDRINMPPDITSCAGQSSLWAWAVGAGPFFYPKHVGFAIGAGHGPRYVVMEVHYDNPSNTEGVADYSGLRFHHTAQTRMYDAGMIWAGWAPFDAMIIPPQQKEWISVGYCSGECTEAGFAQSTLPDKGINIIAILLHTHLQGVKIWTRHIRDGVELPEVARDDNYDFNFQEFQVLPEEVHIKPGDDLVQMCHYQTMDK 240          

Query:  246 IGFSDHGKLENSDLFVV--NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGN-DVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKEFRNF-----------------KETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFEC 1745
            +G SD G+L N+DL V+  +  K    D  ++  G +  D +QDY L +     + F    +R  +TCD  DY I+ GT +II   L        EL++  ++  V  + +LR   P   + P  +++++    + IP+ +TTYWC + +LP    K+HII YE+VI+  ++ IVHH+E+F C  SP   DV +++G C+   KP  L  CR V+AAWAMGA AF YP   G  IGG   S +  LE+H++N     G  D+SG+RL YT +LR+YDAGI+ELGL YT    IPPKQ +F L+GYC+ KC++ ALP  GIYVF SQLHTHL G  V T   R  +E++ +  D+H+  HYQ IR+L K+VN+LPGD+L+T C Y T +R++ T GG  I +EMC+NYI YYP+I+LELCKS +     +     ++ NF                  + F++++W D   ++L+  Y+ AP+   CN S +  F G+W     P++ +    LEK  + C
Sbjct:   73 LGMSDRGELTNADLVVLWDSGTKSYFGDAWSDSEGHVSLDSQQDYELIEAKEKPDGFYLLFKRPFSTCDPKDYLIEEGTVHIIYGLLDQPLASLEELNLSRIHTGVQRVLMLRPDDPSPTLGPDLQTIDVVAPDVIIPSQETTYWCFIQKLPENMPKNHIIMYESVITPGNEAIVHHIEVFEC--SPDMMDVPQYSGSCDDNMKPRKLNYCRHVLAAWAMGAEAFYYPPDAGLAIGGPGSSRFLRLEVHYHNPLLIAGRRDSSGIRLHYTPRLRRYDAGIMELGLVYTPVMAIPPKQHTFYLTGYCTSKCTQTALPPGGIYVFASQLHTHLAGRGVRTVLVRGGKEVEIVQEDQHFSTHYQTIRVLRKMVNILPGDVLLTKCTYNTEDRSKPTVGGFGIMEEMCVNYIHYYPRIQLELCKSHIDMGYLQ-----KYFNFINRFHGNEQCVCGEVDVTQQFSQLDWDDFTGEVLDSLYNTAPIFMHCNQSTARLFPGEWEKQPIPVVTST---LEKHRYPC 582          

Query:  246 IGFSDHGKLENSDLFVV---NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGN-DVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFE---NLPEKEFRN---------FKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFEC 1745
            +G SD G+L N+DL V+       + G D  ++  G +  D +QDY L +     + F    +R  +TCD  DY I+ GT +II   L        EL++  ++  V  + +LR   P   + P  +++++    + IP+ +TTYWC + +LP    K+HII YE+VI+  ++ IVHH+E+F C  SP   DV +++G C+   KP  L  CR V+AAWAMGA AF YP   G  IGG   S +  LE+H++N     G  D+SG+RL YT +LR+YDAGI+ELGL YT    IPPKQ +F L+GYC+ KC++ ALP  GIYVF SQLHTHL G  V T   R  +E++ +  D+H+  HYQ IR+L K+VN+LPGD+L+T C Y T +R++ T GG  I +EMC+NYI YYP+I+LELCKS +     +   N   +   N           + F++++W D   ++L+  Y+ AP+   CN S +  F G+W     P++ +    LEK  + C
Sbjct:   73 LGMSDRGELTNADLVVLWDSGTKSYFG-DAWSDSEGHVSLDSQQDYELIEAKEKPDGFYLLFKRPFSTCDPKDYLIEEGTVHIIYGLLDQPLASLEELNLSRIHTGVQRVLMLRPDDPSPTLGPDLQTIDVVAPDVIIPSQETTYWCFIQKLPENMPKNHIIMYESVITPGNEAIVHHIEVFEC--SPDMMDVPQYSGSCDDNMKPRKLNYCRHVLAAWAMGAEAFYYPPDAGLAIGGPGSSRFLRLEVHYHNPLLIAGRRDSSGIRLHYTPRLRRYDAGIMELGLVYTPVMAIPPKQHTFYLTGYCTSKCTQTALPPGGIYVFASQLHTHLAGRGVRTVLVRGGKEVEIVQEDQHFSTHYQTIRVLRKMVNILPGDVLLTKCTYNTEDRSKPTVGGFGIMEEMCVNYIHYYPRIQLELCKSHIDMGYLQKYFNFINRFHGNEQCVCGEVDVTQQFSQLDWDDFTGEVLDSLYNTAPIFMHCNQSTARLFPGEWEKQPIPVVTST---LEKHRYPC 582          

Query:  246 IGFSDHGKLENSDLFVV---NRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGN-DVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKEFRNF-----------------KETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFEC 1745
            +G SD G+L N+DL V+       + G D  ++  G +  D +QDY L +     + F    +R  +TCD  DY I+ GT +II   L        EL++  ++  V  + +LR   P   + P  +++++    + IP+ +TTYWC + +LP    K+HII YE+VI+  ++ IVHH+E+F C  SP   DV +++G C+   KP  L  CR V+AAWAMGA AF YP   G  IGG   S +  LE+H++N     G  D+SG+RL YT +LR+YDAGI+ELGL YT    IPPKQ +F L+GYC+ KC++ ALP  GIYVF SQLHTHL G  V T   R  +E++ +  D+H+  HYQ IR+L K+VN+LPGD+L+T C Y T +R++ T GG  I +EMC+NYI YYP+I+LELCKS +     +     ++ NF                  + F++++W D   ++L+  Y+ AP+   CN S +  F G+W     P++ +    LEK  + C
Sbjct:   97 LGMSDRGELTNADLVVLWDSGTKSYFG-DAWSDSEGHVSLDSQQDYELIEAKEKPDGFYLLFKRPFSTCDPKDYLIEEGTVHIIYGLLDQPLASLEELNLSRIHTGVQRVLMLRPDDPSPTLGPDLQTIDVVAPDVIIPSQETTYWCFIQKLPENMPKNHIIMYESVITPGNEAIVHHIEVFEC--SPDMMDVPQYSGSCDDNMKPRKLNYCRHVLAAWAMGAEAFYYPPDAGLAIGGPGSSRFLRLEVHYHNPLLIAGRRDSSGIRLHYTPRLRRYDAGIMELGLVYTPVMAIPPKQHTFYLTGYCTSKCTQTALPPGGIYVFASQLHTHLAGRGVRTVLVRGGKEVEIVQEDQHFSTHYQTIRVLRKMVNILPGDVLLTKCTYNTEDRSKPTVGGFGIMEEMCVNYIHYYPRIQLELCKSHIDMGYLQ-----KYFNFINRFHGNEQCVCGEVDVTQQFSQLDWDDFTGEVLDSLYNTAPIFMHCNQSTARLFPGEWEKQPIPVVTST---LEKHRYPC 606          

Query:  237 WSGIGFSDHGKLENSDLFVVNRLKFLGF--DLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIF-----SLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKG-IIDNSGLRLFYTDKLRQYDAGIIELGLE--YTEKNFIPPKQKSFALSGYC-----SEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKS 1499
            W  +GFS  G++  +D+ +        +  D H  +    + D+ Q Y L   + N  Q   T QR + +CD+ D+ I      +I        +K          V+ LNY                 + +   + + V  + +P+++T Y CKV++L  L  KHHI + E  I   +  IVHHM L+HC   P      +  PC      +G  +C  V+AAW  G   +  PE  G PIGGEN +    LEIH+NN  +K G +IDNSGLRL+YTD+LRQ+D GI+  G+      K  IPPK   F   G C     S+ C    +P   + VF   LHTHL G +V   HFRK +++  L  +++Y    Q+   L  I  V+ GD ++  C Y T +RT  T  G+   DEMCL +++YYP I +  C S
Sbjct:   60 WISLGFSPSGEMYGADIVIGGVGPNGNYFNDYHAKEEVMPLLDKEQSYTLLSMMENDGQTIMTFQRAIQSCDEEDFHITAQPIKLIYAYGTSDEIKYHGPRRGTKEVNLLNYV------------PRTSNANATYLSVKVTNVPVPSNKTYYHCKVMKLSDLSTKHHIYQIEPEIE--NPDIVHHMLLYHC---PPTVTTPYENPCYRGD--LG-DVCFGVVAAWGTGGGVYELPENAGIPIGGENKNILYRLEIHYNNPQQKAGSVIDNSGLRLYYTDQLRQHDVGILNTGVLPILPVKYNIPPKAAEFHTYGLCNTSYFSQVCLVSPMPD--LQVFAVLLHTHLAGRKVRVGHFRKGKQIDFLGLNENYNFEMQQTVNLGSIKTVMEGDEIIVECTYNTEDRTGPTKIGLSTFDEMCLAFLYYYPAISVTSCLS 473          

Query:  651 PASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGN----DVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNN----QDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYP----KIELELCKSSVSDVVFENLPEK 1538
            P++  TY C    +P  ++  +I+ +   I   S   VHHM LF C          D     G C  +           ++ AWA  AP    P+ VG  +G  +  +Y +L++H+ +    +D  +   D SGL L  T K + + AGI    L  +    IPP +            C   + P   IY F  + HTH  G  V     R  +    + R     P  Q    +   ++V  GD +   C++    RT  T  G    DEMC  Y+ YY      +    C  S S   F ++P +
Sbjct:   60 PSNSDTYLCMAFPVP-TNQDSYIVDF---IPHASMNTVHHMILFGCQSPSSASSSWDCGGALGTCKDDPS---------IMYAWARNAPPTKLPKDVGFRVGKGSGMSYFVLQVHYGDVSAFRDHHR---DCSGLTLRMTSKPQPFVAGIY---LLMSVDTVIPPGKTVTNA----DVACDYASYP---IYPFAFRTHTHRLGKVVSGYRIRNGK-WTLIGRQSPQLP--QAFYPVNTELSVQYGDTVAARCVFTGEGRTSETVIGGTSDDEMCNFYMMYYMDRRHAVPFMSCMESGSREQFRHIPAE 338          

Query:   45 MRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRR 1757
            MRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLRSTIPISEISPSTRSMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPA TYPEQ                 IHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDL+KQSFECLMR+
Sbjct:    1 MRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLRSTIPISEISPSTRSMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPALTYPEQ-----------------IHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLKKQSFECLMRK 554          

Query:   45 MRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLXXXXXXXXXXXXXXXMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLEKQSFECLMRR 1757
            MRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLRSTIPISEISPSTRSMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPA TYPEQV                      DEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDL+KQSFECLMR+
Sbjct:    1 MRLILLHVFIILKIVISYTKPYQYHATYSRTEGVYDIYWSVEPNLEKIQLKLCQKLNKQFSFPIWSGIGFSDHGKLENSDLFVVNRLKFLGFDLHTNKYGRIIKDERQDYLLKDNIINHEQFCFTIQRKVNTCDKNDYQIDRGTTNIIIFSLKNKQNMNNELHVDFLNYFVVLLQLLRSTIPISEISPSTRSMEITVNYIEIPASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCRKVIAAWAMGAPALTYPEQV----------------------DEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPKIELELCKSSVSDVVFENLPEKEFRNFKETFNRVNWSDKNSKLLERFYDEAPVHQSCNMSDSDSFEGDWNAIITPILETRDYDLKKQSFECLMRK 549          

Query:  669 YWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCR----KVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQDEKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYYPK 1475
            Y C    +P  ++  +I+ YE + +++   I HHM LF C  SP +    F  PC S        +C     K++  WA  A +F YP   G  +GG++   Y +L++H+    +   I D SGL L  + K   Y  GI  L   Y +   I P+ +   L   C  K + +A      Y    + H H  G  +    ++       +       P + +       V + PGDIL+  C++ +T +  VT  G    DEMC  YI    K
Sbjct:   37 YICSSFPVPNHNENSYIVSYEPLANSS---IAHHMLLFGC-SSPFSTEPSF--PCRS--------ICENSREKILFGWARDAKSFHYPSNTGMAVGGKSNINYFVLQVHYL---KPTTIEDKSGLLLELSSKPPDYVVGIFLLFSYYGK---IQPQTRKVNLDVSCRYKGNSEA------YTLAFRTHAHALGRSISG--YKVSLNDGQIELIGKGNPQWPQTFYKSAQVQIKPGDILMARCLFDSTGKDSVTEIGYTHMDEMCNFYIMMVTK 281          

Query:  651 PASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCR---KVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQD---EKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYY 1469
            P  +  Y C       LD K+  +         S    HH+ L H    PG+    +N  C   +      +C+   K++ +WAM A  F  P+ V   IG      Y +++ H+ N D   +     D SG+ +    K     AGI  L  + +    IP     F +   CS        P      F  ++HTH  G  V      +    +   +    +  +  ++     V + PGD L   CI +      V  G     DEMC  YI+Y+
Sbjct:   27 PTKEDQYICHA-----LDLKNDTLFITGFNPKASASHAHHI-LIHSCTEPGSVKPYWN--CEEMNAKDSKPICKSGLKILFSWAMAASGFRLPKDVSVMIGKAVGKQYLVIQSHYKNVDYFRKPNSEPDESGIEITVQRKPTSKLAGIYLLATDGS----IPGHSTVF-MEAACSYTGKTVLHP------FAYRVHTHSLGKLVSGYVIHRKNWTEIGKKSPQVEQMFYPVK---GTVKIYPGDTLAARCIMENKGDKLVKIGNTR-KDEMCNFYIYYW 282          

Query:  651 PASQTTYWCKVIQLPYLDKKHHIIKYEAVISATSQGIVHHMELFHCIRSPGNDVKRFNGPCNSESKPMGLTMCR---KVIAAWAMGAPAFTYPEQVGNPIGGENFSTYAILEIHFNNQD---EKKGIIDNSGLRLFYTDKLRQYDAGIIELGLEYTEKNFIPPKQKSFALSGYCSEKCSRQALPANGIYVFGSQLHTHLTGIQVETRHFRKHRELKPLNRDKHYQPHYQEIRLLPKIVNVLPGDILVTTCIYKTTNRTEVTFGGIEITDEMCLNYIFYY 1469
            P  +  Y C       LD K+  +         S    HH+ L H    PG+    +N  C   +      +C+   K++ +WAM A  F  P+ V   IG      Y +++ H+ N D   +     D SG+ +    K     AGI  L  + +    IP     F +   CS        P      F  ++HTH  G  V      +    +   +    +  +  ++     V + PGD L   CI +      V  G     DEMC  YI+Y+
Sbjct:    6 PTKEDQYICHA-----LDLKNDTLFITGFNPKASASHAHHI-LIHSCTEPGSVKPYWN--CEEMNAKDSKPICKSGLKILFSWAMAASGFRLPKDVSVMIGKAVGKQYLVIQSHYKNVDYFRKPNSEPDESGIEITVQRKPTSKLAGIYLLATDGS----IPGHSTVF-MEAACSYTGKTVLHP------FAYRVHTHSLGKLVSGYVIHRKNWTEIGKKSPQVEQMFYPVK---GTVKIYPGDTLAARCIMENKGDKLVKIGNTR-KDEMCNFYIYYW 261