epidermal growth factor receptor 3

Overview
Nameepidermal growth factor receptor 3 (AEE89451.1)
Smed IDSMED30017456
Length (bp)4767
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of epidermal growth factor receptor 3 (SMED30017456) t-SNE clustered cells

Violin plots show distribution of expression levels for epidermal growth factor receptor 3 (SMED30017456) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of epidermal growth factor receptor 3 (SMED30017456) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for epidermal growth factor receptor 3 (SMED30017456) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30017456

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 16

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30017456SMESG000016935.1 SmedASXL_000685SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30017456SMESG000016935.1 SmedASXL_000685SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
pharynxSMED30017456SMESG000016935.1 dd_Smed_v4_10624_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30017456SMESG000016935.1 dd_Smed_v4_10624_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30017456SMESG000016935.1 dd_Smed_v4_10624_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30017456SMESG000016935.1 dd_Smed_v4_10624_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynxSMED30017456SMESG000016935.1 HM777016smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
cephalic gangliaSMED30017456SMESG000016935.1 HM777016smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
head regionSMED30017456SMESG000016935.1 HM777016smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
neoblastSMED30017456SMESG000016935.1 HM777016smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30017456SMESG000016935.1 HM777016smed_ncbi_20200123PMID:21458439
Fraguas et al., 2011
whole organism asexual adult colorimetric in situ hybridization evidence
X1 cellSMED30017456SMESG000016935.1 isotig10370be_Smed_v2PMID:22543868
Onal et al., 2012
FACS sorted cell population asexual adult RNA-sequencing evidence
epidermisSMED30017456SMESG000016935.1 dd_Smed_v4_10624_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30017456SMESG000016935.1 egfr-3smed_ncbi_20200123PMID:27523733
Lei et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
neoblastSMED30017456SMESG000016935.1 egfr-3smed_ncbi_20200123PMID:27523733
Lei et al., 2016
whole organism asexual adult fluorescence in situ hybridization evidence
neoblastSMED30017456SMESG000016935.1 SMED_32179_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
BLAST of epidermal growth factor receptor 3 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432])

HSP 1 Score: 263.848 bits (673), Expect = 6.994e-71
Identity = 172/549 (31.33%), Postives = 275/549 (50.09%), Query Frame = 1
Query: 2020 IKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEP--CHSMCRT--CSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR---NGCLLANDSTA--CTRCLNHK---------------------LFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINS--KQRKTIFIILSGCFG--FLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            I   +N  LC+  +       S INQ I           + E   C+ +C +  C G   ++  C  C+ +     C++ C+       + E G  C +C  +C    +G L  +      CT+C + K                      + D D+    C   C    N     D    C+ +  T +S   Q     +I +G  G  F++ I+G     +  R +  +  A  + L +   EP   +         PN  +++++  ++L      K LGSGAFG VY+G W VP  + + + + V IK+++ ++    + EF++EA IMAS+ H H + L+GVCLS     LV+    HG L +Y+ ++   I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++++ITDFGLARL++  +       GK+PI+W+A+E +    ++  +DVW+YGVT+WE+ T+  +PY+ + T EI   L++G RL QP I T++VYMVM+KCW+ D   RP F EL + F +  + P+R+L +
Sbjct:  458 IYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQ--CLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHD----CIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTA------PNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VP--EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVI 987          

HSP 2 Score: 150.984 bits (380), Expect = 6.959e-36
Identity = 147/577 (25.48%), Postives = 231/577 (40.03%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQ------KIGNRCIE-CP---NGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEE---------ISPDNRVKFSCNK---TCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ------NCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANN-----VNAPITCQLCHSSCFVDKTLVGTNHACTGPSN 1980
            N  + +PL NL++IRG  L  +  AL I  N+ ++G F L+E+ L+NL  I++  V + QN  L Y +  + W  I+ +P    L +      S+G  +CH  C          +  C+GP++N CQ  T+ V  +      +       C  ECAGGC G    DC  C        CV+ C     +    F ++     +YT G  C  +CP + +  +  CV  C     +      K+   C + CP   +G    S    +  + + IDKF   N  K  +N   +  +T          I    +N      P   +  + VREI G  ++ ++   +++ +  SNL  I   V    ++  +               +   G I I   +  CY   I W           +  DNR   +C      C+ LC+   CWGPG + C SC  +  G  C++ C+   G F  + E  +I C  C P C +       C GP P NC  +C +  +   CV+ C  D    AN+      +    C  CH +C            C GP++
Sbjct:   92 NQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYAD-TIHWQDIVRNPWPSNLTLVS-TNGSSGCGRCHKSC----------TGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFI--NCTK--INGNLIFLVTG---------IHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEF-REFENGSI-CVECDPQCEKMEDGLLTCHGPGPDNC-TKCSHFKDGPNCVEKCP-DGLQGANSFIFKYADPDRECHPCHPNC---------TQGCNGPTS 630          

HSP 3 Score: 53.1434 bits (126), Expect = 5.626e-6
Identity = 28/79 (35.44%), Postives = 38/79 (48.10%), Query Frame = 1
Query: 1594 CDPLCTGQ------CWGPGNEMCYSCAYYKAGNSCVKQCSDS---PGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNC 1803
            CDP C         C GPG + C  C+++K G +CV++C D       F  +      +C  CHP C Q C GPT  +C
Sbjct:  555 CDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDC 633          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432])

HSP 1 Score: 263.077 bits (671), Expect = 9.509e-71
Identity = 172/549 (31.33%), Postives = 275/549 (50.09%), Query Frame = 1
Query: 2020 IKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEP--CHSMCRT--CSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR---NGCLLANDSTA--CTRCLNHK---------------------LFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINS--KQRKTIFIILSGCFG--FLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            I   +N  LC+  +       S INQ I           + E   C+ +C +  C G   ++  C  C+ +     C++ C+       + E G  C +C  +C    +G L  +      CT+C + K                      + D D+    C   C    N     D    C+ +  T +S   Q     +I +G  G  F++ I+G     +  R +  +  A  + L +   EP   +         PN  +++++  ++L      K LGSGAFG VY+G W VP  + + + + V IK+++ ++    + EF++EA IMAS+ H H + L+GVCLS     LV+    HG L +Y+ ++   I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++++ITDFGLARL++  +       GK+PI+W+A+E +    ++  +DVW+YGVT+WE+ T+  +PY+ + T EI   L++G RL QP I T++VYMVM+KCW+ D   RP F EL + F +  + P+R+L +
Sbjct:  432 IYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQ--CLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHD----CIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTA------PNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VP--EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVI 961          

HSP 2 Score: 150.984 bits (380), Expect = 6.163e-36
Identity = 147/577 (25.48%), Postives = 231/577 (40.03%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQ------KIGNRCIE-CP---NGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEISP---------DNRVKFSCNK---TCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ------NCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANN-----VNAPITCQLCHSSCFVDKTLVGTNHACTGPSN 1980
            N  + +PL NL++IRG  L  +  AL I  N+ ++G F L+E+ L+NL  I++  V + QN  L Y +  + W  I+ +P    L +      S+G  +CH  C          +  C+GP++N CQ  T+ V  +      +       C  ECAGGC G    DC  C        CV+ C     +    F ++     +YT G  C  +CP + +  +  CV  C     +      K+   C + CP   +G    S    +  + + IDKF   N  K  +N   +  +T          I    +N      P   +  + VREI G  ++ ++   +++ +  SNL  I   V    ++  +               +   G I I   +  CY   I W  +           DNR   +C      C+ LC+   CWGPG + C SC  +  G  C++ C+   G F  + E  +I C  C P C +       C GP P NC  +C +  +   CV+ C  D    AN+      +    C  CH +C            C GP++
Sbjct:   66 NQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYAD-TIHWQDIVRNPWPSNLTLVS-TNGSSGCGRCHKSC----------TGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFI--NCTK--INGNLIFLVTG---------IHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEF-REFENGSI-CVECDPQCEKMEDGLLTCHGPGPDNC-TKCSHFKDGPNCVEKCP-DGLQGANSFIFKYADPDRECHPCHPNC---------TQGCNGPTS 604          

HSP 3 Score: 53.1434 bits (126), Expect = 5.181e-6
Identity = 28/79 (35.44%), Postives = 38/79 (48.10%), Query Frame = 1
Query: 1594 CDPLCTGQ------CWGPGNEMCYSCAYYKAGNSCVKQCSDS---PGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNC 1803
            CDP C         C GPG + C  C+++K G +CV++C D       F  +      +C  CHP C Q C GPT  +C
Sbjct:  529 CDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDC 607          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432])

HSP 1 Score: 263.077 bits (671), Expect = 9.695e-71
Identity = 172/549 (31.33%), Postives = 275/549 (50.09%), Query Frame = 1
Query: 2020 IKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEP--CHSMCRT--CSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR---NGCLLANDSTA--CTRCLNHK---------------------LFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINS--KQRKTIFIILSGCFG--FLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            I   +N  LC+  +       S INQ I           + E   C+ +C +  C G   ++  C  C+ +     C++ C+       + E G  C +C  +C    +G L  +      CT+C + K                      + D D+    C   C    N     D    C+ +  T +S   Q     +I +G  G  F++ I+G     +  R +  +  A  + L +   EP   +         PN  +++++  ++L      K LGSGAFG VY+G W VP  + + + + V IK+++ ++    + EF++EA IMAS+ H H + L+GVCLS     LV+    HG L +Y+ ++   I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++++ITDFGLARL++  +       GK+PI+W+A+E +    ++  +DVW+YGVT+WE+ T+  +PY+ + T EI   L++G RL QP I T++VYMVM+KCW+ D   RP F EL + F +  + P+R+L +
Sbjct:  458 IYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQ--CLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHD----CIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTA------PNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VP--EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVI 987          

HSP 2 Score: 150.984 bits (380), Expect = 8.002e-36
Identity = 147/577 (25.48%), Postives = 231/577 (40.03%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQ------KIGNRCIE-CP---NGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEE---------ISPDNRVKFSCNK---TCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ------NCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANN-----VNAPITCQLCHSSCFVDKTLVGTNHACTGPSN 1980
            N  + +PL NL++IRG  L  +  AL I  N+ ++G F L+E+ L+NL  I++  V + QN  L Y +  + W  I+ +P    L +      S+G  +CH  C          +  C+GP++N CQ  T+ V  +      +       C  ECAGGC G    DC  C        CV+ C     +    F ++     +YT G  C  +CP + +  +  CV  C     +      K+   C + CP   +G    S    +  + + IDKF   N  K  +N   +  +T          I    +N      P   +  + VREI G  ++ ++   +++ +  SNL  I   V    ++  +               +   G I I   +  CY   I W           +  DNR   +C      C+ LC+   CWGPG + C SC  +  G  C++ C+   G F  + E  +I C  C P C +       C GP P NC  +C +  +   CV+ C  D    AN+      +    C  CH +C            C GP++
Sbjct:   92 NQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYAD-TIHWQDIVRNPWPSNLTLVS-TNGSSGCGRCHKSC----------TGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFI--NCTK--INGNLIFLVTG---------IHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEF-REFENGSI-CVECDPQCEKMEDGLLTCHGPGPDNC-TKCSHFKDGPNCVEKCP-DGLQGANSFIFKYADPDRECHPCHPNC---------TQGCNGPTS 630          

HSP 3 Score: 53.1434 bits (126), Expect = 5.660e-6
Identity = 28/79 (35.44%), Postives = 38/79 (48.10%), Query Frame = 1
Query: 1594 CDPLCTGQ------CWGPGNEMCYSCAYYKAGNSCVKQCSDS---PGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNC 1803
            CDP C         C GPG + C  C+++K G +CV++C D       F  +      +C  CHP C Q C GPT  +C
Sbjct:  555 CDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDC 633          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Human
Match: ERBB2 (erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:3430])

HSP 1 Score: 258.84 bits (660), Expect = 1.867e-70
Identity = 175/557 (31.42%), Postives = 276/557 (49.55%), Query Frame = 1
Query: 2017 LIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCE----PCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCL--LANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICL-KFEETINSKQRKTIFIILS-------GC-----FGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNM-KEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKD 3597
            L   ++N +LC   + P  + Q   N + + LH     +  C      CH +C            C  C  +    +CV+EC  ++ +  +      C  CH EC+  NG +     ++  C  C ++K       +   CV RCP         D  ++ + KF +   + Q   I    S       GC        L  II   V               IK      ++  M+ + +E  +  P       PN  +M+++  ++L      K LGSGAFG VY+G W +P  D + + + V IKV+  N+S  +  E L+EA +MA V   +   L+G+CL+     LV+    +G L  ++++N  ++ S  +L W  QIA GM+YL    ++HRDLAARNVLV   ++++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP I T++VYM+M+KCW+ D   RP F ELVS F +  + P+RF+ + +E +    P D
Sbjct:  189 LALIHHNTHLCFVHTVP--WDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYK-------DPPFCVARCPSGVK----PDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL---RKVKVLGSGAFGTVYKGIW-IP--DGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLT-STVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLD 725          

HSP 2 Score: 66.6254 bits (161), Expect = 3.501e-10
Identity = 61/246 (24.80%), Postives = 106/246 (43.09%), Query Frame = 1
Query: 1273 TVPMLYHHLK---NVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNG-TCYLDRIPWEEI--SPDNRVKFSCNK----------TCDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCR-QN----CTGPTPKNCGGQCRYAIEENTCVKNCS------IDFFPVANNVNAPITCQLCHSSC 1926
            T P+    L+    + EI G   +  +   + +L+   NL+ IR  +  H  A ++ + G  I +LGL+ L+++   +++   N   C++  +PW+++  +P   +  + N+           C  LC  G CWGPG   C +C+ +  G  CV++C    G    +       C  CHP C+ QN    C GP    C   C +  +   CV  C       + + P+    +    CQ C  +C
Sbjct:  113 TAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRIL-HNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGL--PREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVA-CAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC 354          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Human
Match: ERBB2 (erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:3430])

HSP 1 Score: 258.455 bits (659), Expect = 5.945e-70
Identity = 175/557 (31.42%), Postives = 276/557 (49.55%), Query Frame = 1
Query: 2017 LIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCE----PCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCL--LANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICL-KFEETINSKQRKTIFIILS-------GC-----FGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNM-KEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKD 3597
            L   ++N +LC   + P  + Q   N + + LH     +  C      CH +C            C  C  +    +CV+EC  ++ +  +      C  CH EC+  NG +     ++  C  C ++K       +   CV RCP         D  ++ + KF +   + Q   I    S       GC        L  II   V               IK      ++  M+ + +E  +  P       PN  +M+++  ++L      K LGSGAFG VY+G W +P  D + + + V IKV+  N+S  +  E L+EA +MA V   +   L+G+CL+     LV+    +G L  ++++N  ++ S  +L W  QIA GM+YL    ++HRDLAARNVLV   ++++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP I T++VYM+M+KCW+ D   RP F ELVS F +  + P+RF+ + +E +    P D
Sbjct:  465 LALIHHNTHLCFVHTVP--WDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYK-------DPPFCVARCPSGVK----PDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL---RKVKVLGSGAFGTVYKGIW-IP--DGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLT-STVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLD 1001          

HSP 2 Score: 125.946 bits (315), Expect = 2.923e-28
Identity = 156/633 (24.64%), Postives = 255/633 (40.28%), Query Frame = 1
Query:  181 FKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNH----------SENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQN-KICVYECDFDAHQKIG----NRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGV--TVPMLYHHLK---NVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNG-TCYLDRIPWEEI--SPDNRVKFSCNK----------TCDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCR-QN----CTGPTPKNCGGQCRYAIEENTCVKNC------SIDFFPVANNVNAPITCQLCHSSC 1926
             + PA   T+L     L Q C  + GNL ++ L      ++  LSFL+ I E+ G + I +N V+++PL  L+++RG  L  +  AL ++ N             +   L E+ LR+L  I+   V+I +NP L Y +  L W  I        L + +  R S     C   C+      G R   C+G S  +CQ  T+ V       CK    G +P   C  +CA GC G    DC  C        C   C     +    F      + RYT G  C + CP + L  +   C   C     +        RC +C +  C     G  + ++  +      N ++++  K+    L               SF+ +    T P+    L+    + EI G   +  +   + +L+   NL+ IR  +  H  A ++ + G  I +LGL+ L+++   +++   N   C++  +PW+++  +P   +  + N+           C  LC  G CWGPG   C +C+ +  G  CV++C    G        +   C  CHP C+ QN    C GP    C   C +  +   CV  C       + + P+    +    CQ C  +C
Sbjct:   33 LRLPASPETHLDMLRHLYQGCQVVQGNLELTYLP-----TNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTIL-WKDIFHKNNQLALTLIDTNR-SRACHPCSPMCK------GSR---CWGESSEDCQSLTRTVCAGGCARCK----GPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKC-SKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA----------FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRIL-HNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNAR--HCLPCHPECQPQNGSVTCFGPEADQCVA-CAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINC 630          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348])

HSP 1 Score: 450.284 bits (1157), Expect = 1.480e-134
Identity = 369/1233 (29.93%), Postives = 563/1233 (45.66%), Query Frame = 1
Query:  367 DVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVS----EFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP--CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP--NH-----IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFS--LVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIH--GKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI----SPDNRVKFSC------------NKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENT-------CVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGF--YQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCV-KECDNMKNVTIKLEIGDECP---------------QCHKECRNGCLLAN-DSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIIL-SGCFGFLVFIIGFCVLYFR-WRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQIS--IDSDFRPI------SIRNIKSDETSWAAATLQ-----------NDSAYH---LINNSYSKESDKSFLPKRKKAKRNISL 3813
            ++++I    L+VI G  + ++ +AL I  N       + E+ +R LR I + +V I  NP + Y+   +DW ++L DP  QK++ +       +     AKCH  C          +  C+G   N+CQ+  + V  K    C ++ +      C   C GGC G   K+C  C+K   D  C+ +C  R   NH     +F  D     RY  G  C  +CP  LL +N +CV  C    H        EC    C SS+       I T+D           L  +TL  L  C  I G L           +     Y  LK V E + + S  +   Q    +L FL NL+ I    K H V  A+ I+      E           G + I   +  CY+ +I W  I      DN+   +              + CD  C  + CWG   E C  C  +K+  +CV++C D+ G+  +QT   ++KC+ C P C + C G    +C   CR+    N+       CV +C +  FP   NV     C+ CH +C+        ++ CTGP + LG GGC +C+  +K  N+   C + S          + N  IS      V ++ CE C   C+TCS +              + NKCV K  +   N + ++ + D+CP               +CH EC      AN  ST C +C N  +F  D      CV+ CP +  F+   +G+  CL ++  I S+QRKT  +I+ S  FGF V  +   ++Y+R  R  +   +AE+          DM  +     +  PNM R+ +IP S+L      K LG+GAFG V+ G +   R  N  + + V IKV   + +  TDE LEEA  M  + H + L +IG C+  +   +V+ Y   G+L  +L+ + + + +   + +  QIA GM YL K+ ++HRDLA RNVLV   ++++ITDFGL++++    DSI IKSGKV I+WLAIE      Y+ A+DVWA+GVT WEI T+ + PY+ ++T  I +FL+ GNRL QP   + ++Y  +++CW+ DP  RP F  L   F++F + P+ FL    E  N+    D    E  Q  +I    D +  P       S+ ++ S  TS A  T+            N S Y        S ++E +   +PK K+ +++  L
Sbjct:   64 NIQKISFPRLRVIYGDEVFHD-NALYIHKNDK-----VHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC----------NDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDG----RYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEK--CRSSSCP----KICTVDGH---------LTNETLKNLEGCEQIDGHLI----------IEHAFTYEQLK-VLETVKIVSEYITIVQQNFYDLKFLKNLQIIE-GRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQT---SMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNV-----CEKCHPTCY--------DNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRN----------VVQNKCVCKHVEYQPNPSERICM-DQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIA---QCVSECPKNLPFSNPANGE--CLDYD--IASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEM---------VDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRAKN--VKIPVAIKVFQ-TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL----ENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVL 1195          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348])

HSP 1 Score: 450.284 bits (1157), Expect = 5.797e-134
Identity = 369/1233 (29.93%), Postives = 563/1233 (45.66%), Query Frame = 1
Query:  367 DVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVS----EFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP--CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP--NH-----IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFS--LVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIH--GKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI----SPDNRVKFSC------------NKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENT-------CVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGF--YQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCV-KECDNMKNVTIKLEIGDECP---------------QCHKECRNGCLLAN-DSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIIL-SGCFGFLVFIIGFCVLYFR-WRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQIS--IDSDFRPI------SIRNIKSDETSWAAATLQ-----------NDSAYH---LINNSYSKESDKSFLPKRKKAKRNISL 3813
            ++++I    L+VI G  + ++ +AL I  N       + E+ +R LR I + +V I  NP + Y+   +DW ++L DP  QK++ +       +     AKCH  C          +  C+G   N+CQ+  + V  K    C ++ +      C   C GGC G   K+C  C+K   D  C+ +C  R   NH     +F  D     RY  G  C  +CP  LL +N +CV  C    H        EC    C SS+       I T+D           L  +TL  L  C  I G L           +     Y  LK V E + + S  +   Q    +L FL NL+ I    K H V  A+ I+      E           G + I   +  CY+ +I W  I      DN+   +              + CD  C  + CWG   E C  C  +K+  +CV++C D+ G+  +QT   ++KC+ C P C + C G    +C   CR+    N+       CV +C +  FP   NV     C+ CH +C+        ++ CTGP + LG GGC +C+  +K  N+   C + S          + N  IS      V ++ CE C   C+TCS +              + NKCV K  +   N + ++ + D+CP               +CH EC      AN  ST C +C N  +F  D      CV+ CP +  F+   +G+  CL ++  I S+QRKT  +I+ S  FGF V  +   ++Y+R  R  +   +AE+          DM  +     +  PNM R+ +IP S+L      K LG+GAFG V+ G +   R  N  + + V IKV   + +  TDE LEEA  M  + H + L +IG C+  +   +V+ Y   G+L  +L+ + + + +   + +  QIA GM YL K+ ++HRDLA RNVLV   ++++ITDFGL++++    DSI IKSGKV I+WLAIE      Y+ A+DVWA+GVT WEI T+ + PY+ ++T  I +FL+ GNRL QP   + ++Y  +++CW+ DP  RP F  L   F++F + P+ FL    E  N+    D    E  Q  +I    D +  P       S+ ++ S  TS A  T+            N S Y        S ++E +   +PK K+ +++  L
Sbjct:  130 NIQKISFPRLRVIYGDEVFHD-NALYIHKNDK-----VHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC----------NDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDG----RYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEK--CRSSSCP----KICTVDGH---------LTNETLKNLEGCEQIDGHLI----------IEHAFTYEQLK-VLETVKIVSEYITIVQQNFYDLKFLKNLQIIE-GRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQT---SMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNV-----CEKCHPTCY--------DNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRN----------VVQNKCVCKHVEYQPNPSERICM-DQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQ---CVSECPKNLPFSNPANGE--CLDYD--IASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEM---------VDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRAKN--VKIPVAIKVFQ-TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL----ENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVL 1261          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348])

HSP 1 Score: 449.899 bits (1156), Expect = 8.239e-134
Identity = 369/1233 (29.93%), Postives = 563/1233 (45.66%), Query Frame = 1
Query:  367 DVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVS----EFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP--CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP--NH-----IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFS--LVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIH--GKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI----SPDNRVKFSC------------NKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENT-------CVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGF--YQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCV-KECDNMKNVTIKLEIGDECP---------------QCHKECRNGCLLAN-DSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIIL-SGCFGFLVFIIGFCVLYFR-WRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQIS--IDSDFRPI------SIRNIKSDETSWAAATLQ-----------NDSAYH---LINNSYSKESDKSFLPKRKKAKRNISL 3813
            ++++I    L+VI G  + ++ +AL I  N       + E+ +R LR I + +V I  NP + Y+   +DW ++L DP  QK++ +       +     AKCH  C          +  C+G   N+CQ+  + V  K    C ++ +      C   C GGC G   K+C  C+K   D  C+ +C  R   NH     +F  D     RY  G  C  +CP  LL +N +CV  C    H        EC    C SS+       I T+D           L  +TL  L  C  I G L           +     Y  LK V E + + S  +   Q    +L FL NL+ I    K H V  A+ I+      E           G + I   +  CY+ +I W  I      DN+   +              + CD  C  + CWG   E C  C  +K+  +CV++C D+ G+  +QT   ++KC+ C P C + C G    +C   CR+    N+       CV +C +  FP   NV     C+ CH +C+        ++ CTGP + LG GGC +C+  +K  N+   C + S          + N  IS      V ++ CE C   C+TCS +              + NKCV K  +   N + ++ + D+CP               +CH EC      AN  ST C +C N  +F  D      CV+ CP +  F+   +G+  CL ++  I S+QRKT  +I+ S  FGF V  +   ++Y+R  R  +   +AE+          DM  +     +  PNM R+ +IP S+L      K LG+GAFG V+ G +   R  N  + + V IKV   + +  TDE LEEA  M  + H + L +IG C+  +   +V+ Y   G+L  +L+ + + + +   + +  QIA GM YL K+ ++HRDLA RNVLV   ++++ITDFGL++++    DSI IKSGKV I+WLAIE      Y+ A+DVWA+GVT WEI T+ + PY+ ++T  I +FL+ GNRL QP   + ++Y  +++CW+ DP  RP F  L   F++F + P+ FL    E  N+    D    E  Q  +I    D +  P       S+ ++ S  TS A  T+            N S Y        S ++E +   +PK K+ +++  L
Sbjct:  137 NIQKISFPRLRVIYGDEVFHD-NALYIHKNDK-----VHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC----------NDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDG----RYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEK--CRSSSCP----KICTVDGH---------LTNETLKNLEGCEQIDGHLI----------IEHAFTYEQLK-VLETVKIVSEYITIVQQNFYDLKFLKNLQIIE-GRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQT---SMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNV-----CEKCHPTCY--------DNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRN----------VVQNKCVCKHVEYQPNPSERICM-DQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQ---CVSECPKNLPFSNPANGE--CLDYD--IASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEM---------VDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRAKN--VKIPVAIKVFQ-TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL----ENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVL 1268          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348])

HSP 1 Score: 449.514 bits (1155), Expect = 9.602e-134
Identity = 369/1233 (29.93%), Postives = 563/1233 (45.66%), Query Frame = 1
Query:  367 DVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVS----EFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP--CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP--NH-----IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFS--LVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIH--GKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI----SPDNRVKFSC------------NKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENT-------CVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGF--YQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCV-KECDNMKNVTIKLEIGDECP---------------QCHKECRNGCLLAN-DSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIIL-SGCFGFLVFIIGFCVLYFR-WRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQIS--IDSDFRPI------SIRNIKSDETSWAAATLQ-----------NDSAYH---LINNSYSKESDKSFLPKRKKAKRNISL 3813
            ++++I    L+VI G  + ++ +AL I  N       + E+ +R LR I + +V I  NP + Y+   +DW ++L DP  QK++ +       +     AKCH  C          +  C+G   N+CQ+  + V  K    C ++ +      C   C GGC G   K+C  C+K   D  C+ +C  R   NH     +F  D     RY  G  C  +CP  LL +N +CV  C    H        EC    C SS+       I T+D           L  +TL  L  C  I G L           +     Y  LK V E + + S  +   Q    +L FL NL+ I    K H V  A+ I+      E           G + I   +  CY+ +I W  I      DN+   +              + CD  C  + CWG   E C  C  +K+  +CV++C D+ G+  +QT   ++KC+ C P C + C G    +C   CR+    N+       CV +C +  FP   NV     C+ CH +C+        ++ CTGP + LG GGC +C+  +K  N+   C + S          + N  IS      V ++ CE C   C+TCS +              + NKCV K  +   N + ++ + D+CP               +CH EC      AN  ST C +C N  +F  D      CV+ CP +  F+   +G+  CL ++  I S+QRKT  +I+ S  FGF V  +   ++Y+R  R  +   +AE+          DM  +     +  PNM R+ +IP S+L      K LG+GAFG V+ G +   R  N  + + V IKV   + +  TDE LEEA  M  + H + L +IG C+  +   +V+ Y   G+L  +L+ + + + +   + +  QIA GM YL K+ ++HRDLA RNVLV   ++++ITDFGL++++    DSI IKSGKV I+WLAIE      Y+ A+DVWA+GVT WEI T+ + PY+ ++T  I +FL+ GNRL QP   + ++Y  +++CW+ DP  RP F  L   F++F + P+ FL    E  N+    D    E  Q  +I    D +  P       S+ ++ S  TS A  T+            N S Y        S ++E +   +PK K+ +++  L
Sbjct:  125 NIQKISFPRLRVIYGDEVFHD-NALYIHKNDK-----VHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC----------NDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDG----RYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEK--CRSSSCP----KICTVDGH---------LTNETLKNLEGCEQIDGHLI----------IEHAFTYEQLK-VLETVKIVSEYITIVQQNFYDLKFLKNLQIIE-GRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQT---SMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNV-----CEKCHPTCY--------DNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRN----------VVQNKCVCKHVEYQPNPSERICM-DQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQ---CVSECPKNLPFSNPANGE--CLDYD--IASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEM---------VDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRAKN--VKIPVAIKVFQ-TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL----ENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVL 1256          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Celegans
Match: R151.1 (pep chromosome:WBcel235:III:7218813:7221186:1 gene:WBGene00020106.1 transcript:R151.1c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R151.1)

HSP 1 Score: 172.555 bits (436), Expect = 1.229e-45
Identity = 97/264 (36.74%), Postives = 147/264 (55.68%), Query Frame = 1
Query: 2761 LGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVS-HRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKK------ISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQF 3531
            +G GAFG+V++G  + P   N  +    V ++  N+     +EF+ E ++M +V  H + + + G C+  +  C++  Y  +G L  YLQ   K+      I S   L +  QIA GMA+L   GIIHRDLAARN+LV     ++I+DFG++R        I +  G +P+RWL+ E +   TYS  +DVWA+GV LWEI T    PY  +A  +I + L +G RL QP   + ++Y++M  CW      RPSF+ ++S  EQ 
Sbjct:  195 IGEGAFGQVFKGILRGP---NGQVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSR----PGVYIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKIEQI 451          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071653)

HSP 1 Score: 435.647 bits (1119), Expect = 2.006e-128
Identity = 341/1231 (27.70%), Postives = 566/1231 (45.98%), Query Frame = 1
Query:   70 LLLFGVVIFISNICNGSNFN-PDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTL-----RNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLK---NVREIIGLFSLVTFQTKISNLTFLSNLEEI--RLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSCNKTCD------PLCTGQC-----WGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNN---NQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKEC--DNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNK------FSCVTRCPHDRNFTEYQ---DGDFICLKFEET--INSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIK-VIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHE-YVNQQYPKDEDQREMIQ 3621
            LL+   +  I+   + SN    D  N ++C+ +++      P+    + +        CT++ GNL ++ L       + DLSFL++I E++G + I + DVK++    L++IRG TL       E  AL + ++       +  +++ +LR +++  V    N  L ++ + + WS+I+ + T       +F  P     KCH  C          +  C+G     CQK +K  C        C   K  E  C   CAGGC G T KDC  C     +  C   C P   +    + +++  + +Y  G  C  +CP  LL  N  CV  C  D   K G  C+ C NG C  +  G  + +   ID F  +N      N + L Q                ++      +P+    L+    V+EI G  ++     +  NL++  NLE I  R  ++S   A A+ +             +   G + I      CY+  I W  I   P+ +V  + N   D       +C+ QC     WG G + C +C  +    +C+  C    GY ++  +F    C+ CHP CR  C G    +C  +C +  +   CV  C        N  N    C+ CH++C            CTGP + +G G C+ C   I  N+    + L     CP G++   ++       K +  ++ C  CH +C  C+     +++C +C  Y    +C  EC  D+  +     E   EC QCH EC NGC     +  C  C N KLF  ++         F+C ++CP +     YQ    G +       +  I +     +  I++G    +  I   CV+ +  R  Q      +K   +     D + ++   I    N+ +++++  ++L        LG GAFG+VY+G W VP  +N  + + V IK ++ ++   S++EFL EA IMASV H + L L+ VC+S +   L++     G L  Y++ N  KI S ++L W+ QIA GM+YL ++ ++HRDLAARNVLV     ++ITDFGLA+L+    +      GK+PI+WLA+E + +  ++  +DVWA+GVT+WE+ T+ +RP+E +   +I   ++ G +L QPEI +L++Y  ++ CW  D  MRP+F +L + F +F + P R+L +P + +        +D++++I+
Sbjct:   24 LLILACMASITTSSSVSNAGYVDNGNMKVCIGTKSR--LSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPN----ENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSK------MYTLEIPDLRDVLNGQVGFHNNYNLCHM-RTIQWSEIVSNGTDAYYNY-DFTAPERECPKCHESC----------THGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPREC-CHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDK-GGECVPC-NGPCPKTCPGVTVLHAGNIDSF--RNCTVIDGNIRILDQ------TFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAI-VKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAYKFDNRTCKICHPECR-TCNGAGADHCQ-ECVHVRDGQHCVSECP------KNKYNDRGVCRECHATC----------DGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTD-----EEQRECFQCHPEC-NGCT-GPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAV-LVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGA--NLCKLRIVKDAEL---RKGGVLGMGAFGRVYKGVW-VPEGEN--VKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIR 1179          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071654)

HSP 1 Score: 434.876 bits (1117), Expect = 1.085e-127
Identity = 317/1131 (28.03%), Postives = 518/1131 (45.80%), Query Frame = 1
Query:  367 DVKRIPLTNLKVIRGVTL-----RNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLK---NVREIIGLFSLVTFQTKISNLTFLSNLEEI--RLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSCNKTCD------PLCTGQC-----WGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNN---NQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKEC--DNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNK------FSCVTRCPHDRNFTEYQ---DGDFICLKFEET--INSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIK-VIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHE-YVNQQYPKDEDQREMIQ 3621
            DVK++    L++IRG TL       E  AL + ++       +  +++ +LR +++  V    N  L ++ + + WS+I+ + T       +F  P     KCH  C          +  C+G     CQK +K  C        C   K  E  C   CAGGC G T KDC  C     +  C   C P   +    + +++  + +Y  G  C  +CP  LL  N  CV  C  D   K G  C+ C NG C  +  G  + +   ID F  +N      N + L Q                ++      +P+    L+    V+EI G  ++     +  NL++  NLE I  R  ++S   A A+ +             +   G + I      CY+  I W  I   P+ +V  + N   D       +C+ QC     WG G + C +C  +    +C+  C    GY ++  +F    C+ CHP CR  C G    +C  +C +  +   CV  C        N  N    C+ CH++C            CTGP + +G G C+ C   I  N+    + L     CP G++   ++       K +  ++ C  CH +C  C+     +++C +C  Y    +C  EC  D+  +     E   EC QCH EC NGC     +  C  C N KLF  ++         F+C ++CP +     YQ    G +       +  I +     +  I++G    +  I   CV+ +  R  Q      +K   +     D + ++   I    N+ +++++  ++L        LG GAFG+VY+G W VP  +N  + + V IK ++ ++   S++EFL EA IMASV H + L L+ VC+S +   L++     G L  Y++ N  KI S ++L W+ QIA GM+YL ++ ++HRDLAARNVLV     ++ITDFGLA+L+    +      GK+PI+WLA+E + +  ++  +DVWA+GVT+WE+ T+ +RP+E +   +I   ++ G +L QPEI +L++Y  ++ CW  D  MRP+F +L + F +F + P R+L +P + +        +D++++I+
Sbjct:  167 DVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSK------MYTLEIPDLRDVLNGQVGFHNNYNLCHM-RTIQWSEIVSNGTDAYYNY-DFTAPERECPKCHESC----------THGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPREC-CHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDK-GGECVPC-NGPCPKTCPGVTVLHAGNIDSF--RNCTVIDGNIRILDQ------TFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAI-VKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAYKFDNRTCKICHPECR-TCNGAGADHCQ-ECVHVRDGQHCVSECP------KNKYNDRGVCRECHATC----------DGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTD-----EEQRECFQCHPEC-NGCT-GPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAV-LVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIG--ANLCKLRIVKDAEL---RKGGVLGMGAFGRVYKGVW-VPEGEN--VKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIR 1228          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Fly
Match: Eph (gene:FBgn0025936 transcript:FBtr0301285)

HSP 1 Score: 191.815 bits (486), Expect = 4.057e-49
Identity = 104/315 (33.02%), Postives = 166/315 (52.70%), Query Frame = 1
Query: 2623 IKALYSNFKEPDMKNMK---EDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIH-NSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFL 3555
            +K L+ N   P   N +   + +    PN    +     D  + T    +G G FG V RG  K+P   N   +++V IK +   SS+ +  +FL EA IM    H + + L GV        +++ Y ++GSLD +L+ N  K  +  ++   + IA GM+YL+    +HRDLAARNVLVN     +I DFGL+R ++   D+   + GK+P+RW A E +    ++ A+DVW+YGV LWE+ +Y +RPY   +  ++   +++G RL  P      +Y +M+ CW      RP+F  +VST +   + P+  L
Sbjct:  665 VKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIP--PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLL 977          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Fly
Match: Eph (gene:FBgn0025936 transcript:FBtr0089085)

HSP 1 Score: 192.2 bits (487), Expect = 4.336e-49
Identity = 104/315 (33.02%), Postives = 166/315 (52.70%), Query Frame = 1
Query: 2623 IKALYSNFKEPDMKNMK---EDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIH-NSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFL 3555
            +K L+ N   P   N +   + +    PN    +     D  + T    +G G FG V RG  K+P   N   +++V IK +   SS+ +  +FL EA IM    H + + L GV        +++ Y ++GSLD +L+ N  K  +  ++   + IA GM+YL+    +HRDLAARNVLVN     +I DFGL+R ++   D+   + GK+P+RW A E +    ++ A+DVW+YGV LWE+ +Y +RPY   +  ++   +++G RL  P      +Y +M+ CW      RP+F  +VST +   + P+  L
Sbjct:  698 VKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIP--PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLL 1010          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Fly
Match: Eph (gene:FBgn0025936 transcript:FBtr0089084)

HSP 1 Score: 192.2 bits (487), Expect = 4.614e-49
Identity = 104/315 (33.02%), Postives = 166/315 (52.70%), Query Frame = 1
Query: 2623 IKALYSNFKEPDMKNMK---EDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIH-NSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFL 3555
            +K L+ N   P   N +   + +    PN    +     D  + T    +G G FG V RG  K+P   N   +++V IK +   SS+ +  +FL EA IM    H + + L GV        +++ Y ++GSLD +L+ N  K  +  ++   + IA GM+YL+    +HRDLAARNVLVN     +I DFGL+R ++   D+   + GK+P+RW A E +    ++ A+DVW+YGV LWE+ +Y +RPY   +  ++   +++G RL  P      +Y +M+ CW      RP+F  +VST +   + P+  L
Sbjct:  698 VKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIP--PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLL 1010          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4])

HSP 1 Score: 332.028 bits (850), Expect = 3.533e-93
Identity = 308/1131 (27.23%), Postives = 498/1131 (44.03%), Query Frame = 1
Query:  235 QRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTA----KCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP----NHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYEC---DFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKN---GVTV--PMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXV-YGKISIGGTNGTCYLDRIPWEEISPDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ-NCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDN-MKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAE-IKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            + C  + GNL I+ + R +N S     FL+SI E++G + +  N    +PL NL++IRG  L     +L I  N+  +G F L ++ L+NL  I++  V + QN  L + +  + W  I+ +P ++ L V     PSN +     +CH  C          +  C+G  +++CQ  TK V  +      F       C  ECAGGC G    DC  C        CV+ C P+P       F ++     +YT G  C  +CP + +  +  CV  C     +  +     CI C       +    K+C+               +++   + +  NCT I G+L         +   G+    P   +  + VREI G  ++ ++   +++L   SNL  I      ++  S + +  ++I  L  + L+++  G + +   +  C+   + W  +   +  +       +P                           ++CS                 + C PLC +  C GP P  C   C+Y     TCVK+C++ +  V    N  + C  C S C   +        C GP    G   C KC  L    N    C +  CP G   +      S + K     + C PCH  C   S + N  R    C+   L       CDN M++    L+                          R +   +F++        VT C   R     QD   I L     I +     +F+I+    G  V+I    +   + RA +  +  E ++ L  +   P+   ++   I +   ++R++++              G+GAFG VY+G W VP  + + + + V IK+++ S+    + EF++EA IMAS+ H H + L+GVCLS     LV+    HG L  Y+ ++   I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++I+ITDFGLARL+D  +       GK+PI+W+A+E +    ++  +DVW+YGVT+WE+ T+  +PY+ + T +I   L++G RL QP I T++VYMVM+KCW+ D   RP F EL + F +  + P+R+L +
Sbjct:   27 ENCEVVMGNLEITSIERNRNLS-----FLKSIREVTGYVLVALNQFDYLPLENLRIIRGTKLYEGRYSLAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQNKFLCHAD-TIHWHDIIKNPRSELLVV-----PSNNSGNTCKRCHRSC----------NGRCWGHQEDQCQSLTKTVCAEQCDGRCFGPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQC-PQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKMEVEENQTKMCIPC-------TDICPKVCDGIGTGSL----QMAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDMFHGIRALDPDRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIG-GRSLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNREP---------------------------RECSKEQ--------------KICDPLCSEAGCWGPGPDQCL-SCKYFSRGKTCVKSCNLYYGDVREFANGSV-CVECDSQC---EKAGEKGLTCHGP----GPDHCVKCLHLKDGPN----CVE-KCPDGLQGAN-----SFIFKYAETNNECHPCHPNCTQGSVACNRFR----CRTRILYR---TSCDNPMQSYNCSLD--------------------------RNMFDAMFLN--------VTYCTGPR----IQDCVGI-LDRTPLIAAGLIGGLFVIVIIALGVAVYIRRKSIK--KKRALRRFLETELVEPLTPSGAAPNQAQLR---ILKETELKRVKIL--------------GAGAFGMVYKGIW-VP--EGETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVI 994          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Zebrafish
Match: egfra (epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) [Source:ZFIN;Acc:ZDB-GENE-030918-1])

HSP 1 Score: 267.7 bits (683), Expect = 1.362e-72
Identity = 164/502 (32.67%), Postives = 252/502 (50.20%), Query Frame = 1
Query: 2149 CHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTAC--------TRCLNHKLFVDDDKNKFSCVTRCPH------DRNFTEYQDGDFIC---------------LKFEETINSKQRKTIFI-ILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            C+ MC           MC  C+ Y     CV  C+ +     + E+   C +C  EC    LL N++  C        T C N+K       +   CV RCP       D    +Y D   +C               LK  +   S     I   ++ G   F++  +G  VL  R R  + +             EP   + +       PN   ++++  ++       K LGSGAFG V++G W VP  +N  + + V IKV+  + S  +  E ++EA +MASV H H   L+G+CL+     L++    +G L  Y+++N  +I S  +L W  QIA GM YL +R ++HRDLAARNVLV    +++ITDFGLA+L++  +       GKVPI+W+A+E++   TY+  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP I T++VYM+M+KCW+ D   RP F EL++ F +  + P R+L +
Sbjct:  504 CNEMCTADGCWGPGPTMCFGCEHYSRGKHCVASCNLLNGEPREYEVNKTCMECDPEC----LLMNETQTCNGPGPDKCTVCANYK-------DGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENCTQGCTGPDLKDCKDFKSSGLPMIAAGVVGGLLAFVILALGVAVL-LRRRHIRRKRTLRRLLQERELVEPLTPSGEA------PNQALLRILKETEF---KKIKVLGSGAFGTVHKGLW-VPEGEN--VKIPVAIKVLREATSPKANKEIMDEAYVMASVEHPHVCRLLGICLT-STVQLITQLMPYGCLLDYVRENKDRIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESIQHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFTKMARDPSRYLVI 980          

HSP 2 Score: 125.946 bits (315), Expect = 1.816e-28
Identity = 152/583 (26.07%), Postives = 229/583 (39.28%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHS---ENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPR-----PN-HIFGMDSKDKLRYTVGGLCTSQCPAS-LLDQNKICVYECD---FDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSF------NKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKF-------SC---NKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIK-CQTCHPLC-----RQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNV---NAPIT--CQLCHSSCFVDKTLVGTNHACTGP 1974
            N V +IPL NL++IRG +L  +  AL ++ N++   E G  ++E+ L +L  I+   V  + N  L  +   ++W+ IL+  +   + VS  +       KC   C          +  C+G   ++CQ+ TK +  +    C     G  P   C+  CA GC G    DC  C     +  C  +C PR     PN H    +   K  Y+ G  C   CP + ++  +  CV  C    ++  +    +C  C  G C     G  +  +A +           S+N   +    NCT I G++ I   +F      N +G+  P     L  V+EI G   +  +   + +L+   NLE IR   K+    S                 +   G +SI      CY     W+ +  S    VK        +C   N TC+ +CT   CWGPG  MC+ C +Y  G  CV  C+   G      E++  K C  C P C      Q C GP P  C     Y  +   CV  C        + +    A +T  CQ CH +C            CTGP
Sbjct:   91 NTVSKIPLENLRIIRGHSLYEDKFALAVLVNYNNSIEQG--VKELPLTSLTEILKGGVRFNMNNHLCNV-GTIEWADILNMKSLPTI-VSHNISYGKNCGKCDPSC---------FNGSCWGTGPDKCQRMTKVICAEQ---CSGRCKGPRPIDCCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDAC-PRLMLYDPNTHQLAPNPYGK--YSFGATCIKTCPHNYVVTDHGACVRTCSPGTYEVDEGGVRKCKRC-EGLCPKVCNGLGMGPLANV----------LSINATNIDSFENCTKISGNVAILSTTFRGDPHTNTSGLD-PAKLSVLSTVKEITGYLMIQLWPESMQSLSAFENLEVIRGRTKTQGTYSFAVTKTAITHLGMRSLREISDGDVSIVKNKNLCYSSPEHWKRLFKSKQQSVKMIENMDAATCANQNSTCNEMCTADGCWGPGPTMCFGCEHYSRGKHCVASCNLLNG---EPREYEVNKTCMECDPECLLMNETQTCNGPGPDKCTVCANYK-DGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENC---------TQGCTGP 629          

HSP 3 Score: 52.373 bits (124), Expect = 5.589e-6
Identity = 36/89 (40.45%), Postives = 42/89 (47.19%), Query Frame = 1
Query: 1573 KFSCNKTC---DPLC-----TGQCWGPGNEMCYSCAYYKAGNSCVKQCSDS-PG---YFASQTEFKTIKCQTCHPLCRQNCTGPTPKNC 1803
            ++  NKTC   DP C     T  C GPG + C  CA YK G  CV +C    PG       +    T  CQ CH  C Q CTGP  K+C
Sbjct:  546 EYEVNKTCMECDPECLLMNETQTCNGPGPDKCTVCANYKDGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENCTQGCTGPDLKDC 634          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64])

HSP 1 Score: 266.929 bits (681), Expect = 7.531e-72
Identity = 164/506 (32.41%), Postives = 253/506 (50.00%), Query Frame = 1
Query: 2149 CHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTA---------CTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQ----------------------RKTIFI---ILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            C  +C            C  CK +     CV+ C+       +   G  C +C  +C      A D +          C +CL+ K    D  N   CV +CP        Q  +    K+ ET N                          +T  I   ++ G F  ++  +GF + + R    + R L   + L +   EP   +         PN  +++++  ++L      K LG+GAFG VY+G W VP  + + + + V IK+++ S+    + EF++EA IMAS+ H H + L+GVCLS     LV+    HG L  Y+ ++   I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++I+ITDFGLARL++  +       GK+PI+W+A+E +    ++  +DVW+YGVT+WE+ T+  +PY+ + T EI   L++G RL QP I T++VYMVM+KCW+ D   RP F EL + F +  + P+R+L +
Sbjct:  502 CDPLCSVSGCWGPGPNQCLSCKYFSRGRTCVRSCNLYNGDVREFANGSTCVECDSQCEK----AEDKSLTCHGPGPDHCVKCLHLK----DGPN---CVEKCPDG-----LQGANSFIFKYPETNNECHPCHPNCTQGCTGPRIQDCIGILDRTPLIAAGVIGGMFVVVIVALGFAIFFRRKSIKKKRALR--RFLETELVEPLTPSGTA------PNQAQLRILKETEL---KRVKILGTGAFGTVYKGIW-VP--EGETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVI 976          

HSP 2 Score: 152.525 bits (384), Expect = 1.791e-36
Identity = 176/687 (25.62%), Postives = 290/687 (42.21%), Query Frame = 1
Query:   70 LLLFGVVIFISNI--CNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTA----KCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP----NHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNR---CIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKN---GVTV--PMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNI---HGKYIEFXXXXXXXXV-YGKISIGGTNGTCYLDRIPWEEI---------SPDNRVKFSCNK---TCDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKT-IKCQTCHPLCRQ------NCTGPTPKNCGGQCRYAIEENTCVKNCS---------IDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGP 1974
            LLLF +V   + +   +G +  P   N ++  +S+    +KT  + Y          + C  + GNL I+ + R +N S     FL+SI E++G + +  N    +PL NL++IRG  L     +L I  N+  +G F L ++ LRNL  I++  V + QN  L + +  + W  I+ +P ++ L V     PSN +     +CH  C          +  C+GP +++CQ  TK V  +      F       C  ECAGGC G    DC  C        CV+ C P+P       F ++     +YT G  C  +CP + +  +  CV  C  +  +   N    CI+C       +    K+C+               +++   + +  NCT I G+L         +   G+    P   +  + VREI G  ++ ++   +++L+  SNL    +++   T+ S +++     ++I  L  + L+++  G + +   +  C+   + W  +           DNR    C++    CDPLC+   CWGPG   C SC Y+  G +CV+ C+    Y     EF     C  C   C +       C GP P +C  +C +  +   CV+ C          I  +P  NN      C  CH +C            CTGP
Sbjct:    7 LLLFCLVFTFAVLQRSSGQSVCPGTDN-KLSTLSDLDQQYKTLRKFY----------ENCEVVMGNLEITSIERNRNLS-----FLKSIREVTGYVLVALNQFDYLPLENLRIIRGTKLYEGRYSLAIFLNYRRDGYFGLRQLGLRNLTEILNGGVYVDQNKFLCHAD-TIHWQDIIKNPRSELLVV-----PSNNSGNTCRRCHRSC----------NGRCWGPQEDQCQSLTKTVCAEQCDGRCFGPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQC-PQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKTEVEENNIKMCIQC-------TEICPKMCDGIGTGSL----QSAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDMYHGIRALDPERLNVFRTVREITGYLNIQSWPENMTDLSVFSNL----VTIGGRTLYSGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQKAKIKDNRDPRECSQQRMVCDPLCSVSGCWGPGPNQCLSCKYFSRGRTCVRSCNL---YNGDVREFANGSTCVECDSQCEKAEDKSLTCHGPGPDHC-VKCLHLKDGPNCVEKCPDGLQGANSFIFKYPETNN-----ECHPCHPNC---------TQGCTGP 627          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Zebrafish
Match: erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:ZFIN;Acc:ZDB-GENE-031118-121])

HSP 1 Score: 265.003 bits (676), Expect = 1.527e-71
Identity = 176/556 (31.65%), Postives = 273/556 (49.10%), Query Frame = 1
Query: 2017 LIKTNNNQYLCHKGSCPKGFYQSVIN--QNISHLHKNIVHQSSCEPCHSMCRTCSGSTN----EKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACT-----RCLNHKLFVDDDKNKFSCVTRCP-----HDRNFTEYQDGDFICLKFEETINSK----------QRKT----IFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHE 3570
            L+  +NN  LC+  S P   + S+++  Q  + +  N   Q +C     +C    G +         C  C  Y    +CV+ C+ +     + E G  C  CH ECR      N + +CT     +C +   F D D     CV RCP           +Y +    CL  E                Q+KT       I  G     + ++   V Y R + +Q +            KE   + ++E  +  P       PN  +M+++  ++L      + LGSGAFG V++G W     D + + + V IKV+  N+S  +  E L+EA +MA V+  +   L+G+CL+     LV+    +G L  Y+++N  +I S  +L W  QIA GM+YL +  ++HRDLAARNVLV + ++++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PYE     +I   L+ G RL QP   T EVYM+M+KCW  DP  RP F +LV  F    + P R++ + +E
Sbjct:  460 LVLIHNNSRLCYTSSLP---WTSLLHPTQGPNLISNNNKDQQTCVSEGKICDPLCGDSGCWGPGPSQCVSCLNYKRGTECVELCNVLHGSVREFEDGFNCVPCHPECRP----INGTASCTGPGPDQCTDCTHFQDGD----VCVERCPSGVKEEQHTVWKYSNATGHCLPCETNCTVSCPLDDRGCPIQQKTGPGTTVAITVGGVLLFIILLALLVFYLRRQKHQKK------------KETIRRRLQEHELVEPLTPSGAMPNQAQMRILKETEL---KKLRVLGSGAFGTVFKGIWA---PDGENVRIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCRLLGICLT-STVQLVTQLMPYGCLLDYVRENKDRIGSQYLLSWCVQIAKGMSYLEEVRLVHRDLAARNVLVKNPNHVKITDFGLARLLDIDEKEYHADGGKVPIKWMALESILHRKFTHQSDVWSYGVTVWELMTFGMKPYESFQARDIPELLEAGERLSQPCNCTKEVYMIMVKCWQIDPDNRPRFKDLVEEFTTMARDPSRYVVIQNE 985          

HSP 2 Score: 159.073 bits (401), Expect = 1.593e-38
Identity = 176/608 (28.95%), Postives = 254/608 (41.78%), Query Frame = 1
Query:  241 CTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNH--SENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAP----RPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIG--------NRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVT-----VPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNG-TCYLDRIPWEE----------ISPDNRVKFSC---NKTCDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFK-TIKCQTCHPLCR-----QNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNV----NAPITCQLCHSSCFV 1932
            C  ++GNL I+ L       +PDLSFL+ I+E+ G + I +  V+ +PL NL++IRG  L     AL + +N   S+ G  L E+ LR+L  I+   V I  NP L +  +N++W   +     + L + +   P N   +C + C         +S  C+G    +CQ  T    +     CK  K  +  C  +CA GC G    DC  C        C  SC P     P       +KDK +++ G  C  QCP + L     C   C     + I          +C +C  G C     G  + N+  +            +N   +   T C  I G L     SF  N  T      P     LK + EI G   +  +   + +L+   NL+ IR  +    V S + +    IE LGL+ L+ V G + +   N   CY   +PW            IS +N+ + +C    K CDPLC    CWGPG   C SC  YK G  CV+ C+   G   S  EF+    C  CHP CR      +CTGP P  C   C +  + + CV+ C        + V    NA   C  C ++C V
Sbjct:   55 CQVVHGNLEITHLQ-----GNPDLSFLQEIVEVQGYVLIAHVSVRSLPLDNLRIIRGSQLYKSNYALAVHNNSNSSQAGLGLRELRLRSLTEILLGGVYIWGNPQLCF-PRNINWEDTVSKVQNKPLHLQDI--PKN-CPRCSSAC---------KSGGCWGEKDQDCQTLTSVNCSSGCSRCKGPKPSDC-CHVQCAAGCTGPKDSDCLACRHFNDSGTCKDSCPPPTIYDPITFQSKPNKDK-KFSFGATCVKQCPHNYLAMEVACTMVCPKANKEVISVEPDGQETQKCEKC-EGECPKVCYGLGMGNLQGVS----------VVNSTNIGMFTGCEKIYGSLAFLSDSFKGNADTNSSGLQPSDLEKLKTIEEITGYLYIDAWSENLLDLSVFENLKVIRGRMLYKGVFS-LGVQSLQIESLGLRSLRSVSGGLVLIHNNSRLCYTSSLPWTSLLHPTQGPNLISNNNKDQQTCVSEGKICDPLCGDSGCWGPGPSQCVSCLNYKRGTECVELCNVLHG---SVREFEDGFNCVPCHPECRPINGTASCTGPGPDQC-TDCTHFQDGDVCVERCPSGVKEEQHTVWKYSNATGHCLPCETNCTV 626          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Zebrafish
Match: erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:ZFIN;Acc:ZDB-GENE-031118-121])

HSP 1 Score: 265.003 bits (676), Expect = 1.527e-71
Identity = 176/556 (31.65%), Postives = 273/556 (49.10%), Query Frame = 1
Query: 2017 LIKTNNNQYLCHKGSCPKGFYQSVIN--QNISHLHKNIVHQSSCEPCHSMCRTCSGSTN----EKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACT-----RCLNHKLFVDDDKNKFSCVTRCP-----HDRNFTEYQDGDFICLKFEETINSK----------QRKT----IFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHE 3570
            L+  +NN  LC+  S P   + S+++  Q  + +  N   Q +C     +C    G +         C  C  Y    +CV+ C+ +     + E G  C  CH ECR      N + +CT     +C +   F D D     CV RCP           +Y +    CL  E                Q+KT       I  G     + ++   V Y R + +Q +            KE   + ++E  +  P       PN  +M+++  ++L      + LGSGAFG V++G W     D + + + V IKV+  N+S  +  E L+EA +MA V+  +   L+G+CL+     LV+    +G L  Y+++N  +I S  +L W  QIA GM+YL +  ++HRDLAARNVLV + ++++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PYE     +I   L+ G RL QP   T EVYM+M+KCW  DP  RP F +LV  F    + P R++ + +E
Sbjct:  460 LVLIHNNSRLCYTSSLP---WTSLLHPTQGPNLISNNNKDQQTCVSEGKICDPLCGDSGCWGPGPSQCVSCLNYKRGTECVELCNVLHGSVREFEDGFNCVPCHPECRP----INGTASCTGPGPDQCTDCTHFQDGD----VCVERCPSGVKEEQHTVWKYSNATGHCLPCETNCTVSCPLDDRGCPIQQKTGPGTTVAITVGGVLLFIILLALLVFYLRRQKHQKK------------KETIRRRLQEHELVEPLTPSGAMPNQAQMRILKETEL---KKLRVLGSGAFGTVFKGIWA---PDGENVRIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCRLLGICLT-STVQLVTQLMPYGCLLDYVRENKDRIGSQYLLSWCVQIAKGMSYLEEVRLVHRDLAARNVLVKNPNHVKITDFGLARLLDIDEKEYHADGGKVPIKWMALESILHRKFTHQSDVWSYGVTVWELMTFGMKPYESFQARDIPELLEAGERLSQPCNCTKEVYMIMVKCWQIDPDNRPRFKDLVEEFTTMARDPSRYVVIQNE 985          

HSP 2 Score: 159.073 bits (401), Expect = 1.593e-38
Identity = 176/608 (28.95%), Postives = 254/608 (41.78%), Query Frame = 1
Query:  241 CTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNH--SENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAP----RPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIG--------NRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVT-----VPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNG-TCYLDRIPWEE----------ISPDNRVKFSC---NKTCDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFK-TIKCQTCHPLCR-----QNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNV----NAPITCQLCHSSCFV 1932
            C  ++GNL I+ L       +PDLSFL+ I+E+ G + I +  V+ +PL NL++IRG  L     AL + +N   S+ G  L E+ LR+L  I+   V I  NP L +  +N++W   +     + L + +   P N   +C + C         +S  C+G    +CQ  T    +     CK  K  +  C  +CA GC G    DC  C        C  SC P     P       +KDK +++ G  C  QCP + L     C   C     + I          +C +C  G C     G  + N+  +            +N   +   T C  I G L     SF  N  T      P     LK + EI G   +  +   + +L+   NL+ IR  +    V S + +    IE LGL+ L+ V G + +   N   CY   +PW            IS +N+ + +C    K CDPLC    CWGPG   C SC  YK G  CV+ C+   G   S  EF+    C  CHP CR      +CTGP P  C   C +  + + CV+ C        + V    NA   C  C ++C V
Sbjct:   55 CQVVHGNLEITHLQ-----GNPDLSFLQEIVEVQGYVLIAHVSVRSLPLDNLRIIRGSQLYKSNYALAVHNNSNSSQAGLGLRELRLRSLTEILLGGVYIWGNPQLCF-PRNINWEDTVSKVQNKPLHLQDI--PKN-CPRCSSAC---------KSGGCWGEKDQDCQTLTSVNCSSGCSRCKGPKPSDC-CHVQCAAGCTGPKDSDCLACRHFNDSGTCKDSCPPPTIYDPITFQSKPNKDK-KFSFGATCVKQCPHNYLAMEVACTMVCPKANKEVISVEPDGQETQKCEKC-EGECPKVCYGLGMGNLQGVS----------VVNSTNIGMFTGCEKIYGSLAFLSDSFKGNADTNSSGLQPSDLEKLKTIEEITGYLYIDAWSENLLDLSVFENLKVIRGRMLYKGVFS-LGVQSLQIESLGLRSLRSVSGGLVLIHNNSRLCYTSSLPWTSLLHPTQGPNLISNNNKDQQTCVSEGKICDPLCGDSGCWGPGPSQCVSCLNYKRGTECVELCNVLHG---SVREFEDGFNCVPCHPECRPINGTASCTGPGPDQC-TDCTHFQDGDVCVERCPSGVKEEQHTVWKYSNATGHCLPCETNCTV 626          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853])

HSP 1 Score: 271.166 bits (692), Expect = 1.822e-73
Identity = 161/497 (32.39%), Postives = 259/497 (52.11%), Query Frame = 1
Query: 2200 CHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKEC--RNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRN------FTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISID 3642
            C +C G+   + C++ C+ +     +   G +C  CH +C  +NG L  N + A  +C+    ++D +     CV +CP            +Y D D IC      +N      +FI +S  F     +    +         T I+  I+      K+  M+ + +D +  P       PN  +M+++  ++L        LGSGAFG VY+G W +P  D + I + V IKV+  N+S  +  E L+EA +MA V   +   L+G+CL+     LV+    +G L  Y+++N  +I+S  +L W  QIA GM YL    ++HRDLAARNVLV    +++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP + T++VYM+M+KCW+ D   RP F +LV    +  + P R++ + +E    Q      Q     L ++ +D
Sbjct:  528 CVRCNGFLRGHDCIESCNVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEA-HQCMECAHYLDGE----DCVEQCPSGVKGNSFVPIWKYPDKDRICQLC--NVNCSHSYVMFIGISTVFAASSIV----ISILIVITISTAIVLYIRRRKQLKKKHTMRRLLQDELVEPLTPSGAIPNQAQMRILKETEL---KKMMILGSGAFGTVYKGIW-IP--DGENIKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLT-STVQLVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDETEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQASPMTTQFYSALLQEVGMD 1006          

HSP 2 Score: 126.716 bits (317), Expect = 1.464e-28
Identity = 151/593 (25.46%), Postives = 242/593 (40.81%), Query Frame = 1
Query:  241 CTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLL-DQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVRE---IIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSCNK----------TCDPLCTG-QCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCR-QN----CTGPTPKNCGGQCRYAIEENTCVKNCSI-----DFFPVANNVNAPITCQLCHSSC 1926
            C  I GNL I+ L       D D+SFL+ I E+ G + I +N +  +PL NL++IRG  L  E  AL ++ N   +GT  L E+ ++NL  I+   VI+  N  L + +  L W+ IL    +Q+   +E V  S+    C   C   +   G +S FC+G  +  CQ  T  + N   + CK   +    C  +CA GC G  + DC  C     +  C   C P   +    +     +  RYT G  C + CP + L  +   C   C  D  + I     +C   +   S   Y L       + + +  +  ++N   +     CT I G L +    F     T+P     L++      +I    + ++  ++ +L    NL  I   +  +   S +  +            +   G + I G    C+L+  PW  +  +P   +  + NK           C   C G +CWGPG   C  C  +  G+ C++ C+   GY   +      +C  CHP C  QN    C G     C  +C + ++   CV+ C        F P+    +    CQLC+ +C
Sbjct:   65 CQVIQGNLEITYLKE-----DNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRGTQLYQERYALAVLSNSDPSGTAGLRELRMKNLTEILKGGVIMENNTQLCFQDTVL-WADILSQSNSQR---NEVVLGSSNRPTCSPGCG--SLPSG-KSGFCWGEGQEYCQILTSTICNSGCQRCKGNHSTHC-CHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCPYNYLATEVGSCTLFCPQDNQEVIVGNVQKCEKCDKQCSKVCYGL------GRDFLRTTQ--AVNASIIHHFQGCTKIFGSLFL----FYSASPTLPTKAKPLRSKETPACLIRYIYIESWPEELKSLNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWASLFRNPRQTILKTINKPQEACDQEGQNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIESCNVLDGY--PREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQC-MECAHYLDGEDCVEQCPSGVKGNSFVPIWKYPDKDRICQLCNVNC 629          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853])

HSP 1 Score: 270.396 bits (690), Expect = 2.408e-73
Identity = 162/497 (32.60%), Postives = 261/497 (52.52%), Query Frame = 1
Query: 2200 CHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKEC--RNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRN------FTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISID 3642
            C +C G+   + C++ C+ +     +   G +C  CH +C  +NG L  N + A  +C+    ++D +     CV +CP            +Y D D IC      +N      +FI +S    ++V  I   +         T I+  I+      K+  M+ + +D +  P       PN  +M+++  ++L        LGSGAFG VY+G W +P  D + I + V IKV+  N+S  +  E L+EA +MA V   +   L+G+CL+     LV+    +G L  Y+++N  +I+S  +L W  QIA GM YL    ++HRDLAARNVLV    +++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP + T++VYM+M+KCW+ D   RP F +LV    +  + P R++ + +E    Q      Q     L ++ +D
Sbjct:  494 CVRCNGFLRGHDCIESCNVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEA-HQCMECAHYLDGE----DCVEQCPSGVKGNSFVPIWKYPDKDRICQLC--NVNCSHSYVMFIGISTVQVYMVASIV--ISILIVITISTAIVLYIRRRKQLKKKHTMRRLLQDELVEPLTPSGAIPNQAQMRILKETEL---KKMMILGSGAFGTVYKGIW-IP--DGENIKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLT-STVQLVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDETEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQASPMTTQFYSALLQEVGMD 974          

HSP 2 Score: 102.449 bits (254), Expect = 3.895e-21
Identity = 144/605 (23.80%), Postives = 226/605 (37.36%), Query Frame = 1
Query:  241 CTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKN-----EC-------QKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLL-DQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSF-----NKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSCNK---------TCDPLCTG-QCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCR-QN----CTGPTPKNCGGQCRYAIEENTCVKNCSI-----DFFPVANNVNAPITCQLCHSSC 1926
            C  I GNL I+ L       D D+SFL+ I E+ G + I +N +  +PL NL++IRG  L  E  AL ++ N   +GT            I+   VI+  N  L + +  L W+ IL      ++ + +   P            Y+      R+  CF          EC          T  + N   + CK   +    C  +CA GC G  + DC  C     +  C   C P   +    +     +  RYT G  C + CP + L  +   C   C  D  + I     +C   +   S   Y L       + + +  +  ++N   +     CT I G L     SF       N V         K + EI G   + ++  ++ +L    NL  I   +  +   S +  +            +   G + I G    C+L+  PW  +  +P   +  + NK          C   C G +CWGPG   C  C  +  G+ C++ C+   GY   +      +C  CHP C  QN    C G     C  +C + ++   CV+ C        F P+    +    CQLC+ +C
Sbjct:   32 CQVIQGNLEITYLKE-----DNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRGTQLYQERYALAVLSNSDPSGT----------AEILKGGVIMENNTQLCFQDTVL-WADILSQ-ILSRIMLLQIPPP------------YFQISHTGRNFMCFASGAGLAIRCECFVSCSFPLPVTSTICNSGCQRCKGNHSTHC-CHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCPYNYLATEVGSCTLFCPQDNQEVIVGNVQKCEKCDKQCSKVCYGL------GRDFLRTTQ--AVNASIIHHFQGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFKTLEEITGYIYIESWPEELKSLNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWASLFRNPRQTILKTINKPQEAYQEGQNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIESCNVLDGY--PREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQC-MECAHYLDGEDCVEQCPSGVKGNSFVPIWKYPDKDRICQLCNVNC 595          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853])

HSP 1 Score: 269.24 bits (687), Expect = 2.464e-73
Identity = 155/470 (32.98%), Postives = 250/470 (53.19%), Query Frame = 1
Query: 2200 CHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKEC--RNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRN------FTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIH-NSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            C +C G+   + C++ C+ +     +   G +C  CH +C  +NG L  N + A  +C+    ++D +     CV +CP            +Y D D IC      +N      +FI +S     +  +    +         T I+  I+      K+  M+ + +D +  P       PN  +M+++  ++L        LGSGAFG VY+G W +P  D + I + V IKV+  N+S  +  E L+EA +MA V   +   L+G+CL+     LV+    +G L  Y+++N  +I+S  +L W  QIA GM YL    ++HRDLAARNVLV    +++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP + T++VYM+M+KCW+ D   RP F +LV    +  + P R++ +
Sbjct:  342 CVRCNGFLRGHDCIESCNVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEA-HQCMECAHYLDGE----DCVEQCPSGVKGNSFVPIWKYPDKDRICQLC--NVNCSHSYVMFIGISTVLYQVYMVASIVISILIVITISTAIVLYIRRRKQLKKKHTMRRLLQDELVEPLTPSGAIPNQAQMRILKETEL---KKMMILGSGAFGTVYKGIW-IP--DGENIKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLT-STVQLVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDETEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVI 797          

HSP 2 Score: 63.5438 bits (153), Expect = 3.427e-9
Identity = 75/265 (28.30%), Postives = 109/265 (41.13%), Query Frame = 1
Query:  241 CTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKI 1023
            C  I GNL I+ L       D D+SFL+ I E+ G + I +N +  +PL NL++IRG  L  E  AL ++ N   +GT  L E+ ++NL  I+   VI+  N  L + +  L W+ IL            F+  ++G A     CE +     V   F    +   C    +  K      C         C  +CA GC G  + DC  C     +  C   C P   +    +     +  RYT G  C + CP      N I
Sbjct:   32 CQVIQGNLEITYLK-----EDNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRGTQLYQERYALAVLSNSDPSGTAGLRELRMKNLTEILKGGVIMENNTQLCFQDTVL-WADILR---------RNFMCFASG-AGLAIRCECF-----VSCSFPLPVTSTICNSGCQRCKGNHSTHC---------CHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCPCKYFLLNII 266          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853])

HSP 1 Score: 266.159 bits (679), Expect = 1.169e-71
Identity = 160/501 (31.94%), Postives = 260/501 (51.90%), Query Frame = 1
Query: 2200 CHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKEC--RNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRN------FTEYQDGDFIC----LKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISID 3642
            C +C G+   + C++ C+ +     +   G +C  CH +C  +NG L  N + A  +C+    ++D +     CV +CP            +Y D D IC    +    + N    +   I+      ++V  I   +         T I+  I+      K+  M+ + +D +  P       PN  +M+++  ++L        LGSGAFG VY+G W +P  D + I + V IKV+  N+S  +  E L+EA +MA V   +   L+G+CL+     LV+    +G L  Y+++N  +I+S  +L W  QIA GM YL    ++HRDLAARNVLV    +++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP + T++VYM+M+KCW+ D   RP F +LV    +  + P R++ + +E    Q      Q     L ++ +D
Sbjct:  520 CVRCNGFLRGHDCIESCNVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEA-HQCMECAHYLDGE----DCVEQCPSGVKGNSFVPIWKYPDKDRICQLCNVNCSHSCNQLDERGCPILPDNSQVYMVASIV--ISILIVITISTAIVLYIRRRKQLKKKHTMRRLLQDELVEPLTPSGAIPNQAQMRILKETEL---KKMMILGSGAFGTVYKGIW-IP--DGENIKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLT-STVQLVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDETEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQASPMTTQFYSALLQEVGMD 1006          

HSP 2 Score: 132.88 bits (333), Expect = 2.479e-30
Identity = 155/595 (26.05%), Postives = 242/595 (40.67%), Query Frame = 1
Query:  241 CTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPAS-LLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSF----NK-NGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSCNK----------TCDPLCTG-QCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCR-QN----CTGPTPKNCGGQCRYAIEENTCVKNCSI-----DFFPVANNVNAPITCQLCHSSC 1926
            C  I GNL I+ L       D D+SFL+ I E+ G + I +N +  +PL NL++IRG  L  E  AL ++ N   +GT  L E+ ++NL  I+   VI+  N  L + +  L W+ IL    +Q+   +E V  S+   +C T           +S FC+G  +  CQ  T  + N   + CK   +    C  +CA GC G  + DC  C     +  C   C P   +    +     +  RYT G  C + CP + L  +   C   C  D  + I     +C   +   S   Y L       + + +  +  ++N   +     CT I G L     SF    NK N V         K + EI G   + ++  ++ +L    NL  I   +  +   S +  +            +   G + I G    C+L+  PW  +  +P   +  + NK           C   C G +CWGPG   C  C  +  G+ C++ C+   GY   +      +C  CHP C  QN    C G     C  +C + ++   CV+ C        F P+    +    CQLC+ +C
Sbjct:   49 CQVIQGNLEITYLKE-----DNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRGTQLYQERYALAVLSNSDPSGTAGLRELRMKNLTEILKGGVIMENNTQLCFQDTVL-WADILSQSNSQR---NEVVLGSS-NRQCPTCSPGCGSLPSGKSGFCWGEGQEYCQILTSTICNSGCQRCKGNHSTHC-CHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCPYNYLATEVGSCTLFCPQDNQEVIVGNVQKCEKCDKQCSKVCYGL------GRDFLRTTQ--AVNASIIHHFQGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFKTLEEITGYIYIESWPEELKSLNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWASLFRNPRQTILKTINKPQEACDQEGQNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIESCNVLDGY--PREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQC-MECAHYLDGEDCVEQCPSGVKGNSFVPIWKYPDKDRICQLCNVNC 621          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853])

HSP 1 Score: 265.774 bits (678), Expect = 1.458e-71
Identity = 160/501 (31.94%), Postives = 260/501 (51.90%), Query Frame = 1
Query: 2200 CHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKEC--RNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRN------FTEYQDGDFIC----LKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISID 3642
            C +C G+   + C++ C+ +     +   G +C  CH +C  +NG L  N + A  +C+    ++D +     CV +CP            +Y D D IC    +    + N    +   I+      ++V  I   +         T I+  I+      K+  M+ + +D +  P       PN  +M+++  ++L        LGSGAFG VY+G W +P  D + I + V IKV+  N+S  +  E L+EA +MA V   +   L+G+CL+     LV+    +G L  Y+++N  +I+S  +L W  QIA GM YL    ++HRDLAARNVLV    +++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP + T++VYM+M+KCW+ D   RP F +LV    +  + P R++ + +E    Q      Q     L ++ +D
Sbjct:  528 CVRCNGFLRGHDCIESCNVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEA-HQCMECAHYLDGE----DCVEQCPSGVKGNSFVPIWKYPDKDRICQLCNVNCSHSCNQLDERGCPILPDNSQVYMVASIV--ISILIVITISTAIVLYIRRRKQLKKKHTMRRLLQDELVEPLTPSGAIPNQAQMRILKETEL---KKMMILGSGAFGTVYKGIW-IP--DGENIKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLT-STVQLVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDETEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQASPMTTQFYSALLQEVGMD 1014          

HSP 2 Score: 132.109 bits (331), Expect = 3.842e-30
Identity = 155/595 (26.05%), Postives = 242/595 (40.67%), Query Frame = 1
Query:  241 CTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPAS-LLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSF----NK-NGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSCNK----------TCDPLCTG-QCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCR-QN----CTGPTPKNCGGQCRYAIEENTCVKNCSI-----DFFPVANNVNAPITCQLCHSSC 1926
            C  I GNL I+ L       D D+SFL+ I E+ G + I +N +  +PL NL++IRG  L  E  AL ++ N   +GT  L E+ ++NL  I+   VI+  N  L + +  L W+ IL    +Q+   +E V  S+   +C T           +S FC+G  +  CQ  T  + N   + CK   +    C  +CA GC G  + DC  C     +  C   C P   +    +     +  RYT G  C + CP + L  +   C   C  D  + I     +C   +   S   Y L       + + +  +  ++N   +     CT I G L     SF    NK N V         K + EI G   + ++  ++ +L    NL  I   +  +   S +  +            +   G + I G    C+L+  PW  +  +P   +  + NK           C   C G +CWGPG   C  C  +  G+ C++ C+   GY   +      +C  CHP C  QN    C G     C  +C + ++   CV+ C        F P+    +    CQLC+ +C
Sbjct:   57 CQVIQGNLEITYLKE-----DNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRGTQLYQERYALAVLSNSDPSGTAGLRELRMKNLTEILKGGVIMENNTQLCFQDTVL-WADILSQSNSQR---NEVVLGSS-NRQCPTCSPGCGSLPSGKSGFCWGEGQEYCQILTSTICNSGCQRCKGNHSTHC-CHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCPYNYLATEVGSCTLFCPQDNQEVIVGNVQKCEKCDKQCSKVCYGL------GRDFLRTTQ--AVNASIIHHFQGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFKTLEEITGYIYIESWPEELKSLNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWASLFRNPRQTILKTINKPQEACDQEGQNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIESCNVLDGY--PREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQC-MECAHYLDGEDCVEQCPSGVKGNSFVPIWKYPDKDRICQLCNVNC 629          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Mouse
Match: Erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:95410])

HSP 1 Score: 269.626 bits (688), Expect = 4.551e-73
Identity = 176/563 (31.26%), Postives = 288/563 (51.15%), Query Frame = 1
Query: 2017 LIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCE----PCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR----NGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPH----DRNFT---EYQDGDFICLKF------------EETINSKQRKT-IFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKD 3597
            L   + N +LC   + P  + Q   N + + LH     + +C      C+S+C            C  C  +    +CV+EC   K +  +   G  C  CH EC+    +     +++  C  C ++K       +  SCV RCP     D ++    +Y D + IC               E    ++QR + +  I++   G L+F+I   V+    +  + +I           K    + ++E  +  P       PN  +M+++  ++L      K LGSGAFG VY+G W +P  D + + + V IKV+  N+S  +  E L+EA +MA V   +   L+G+CL+     LV+    +G L  +++++  ++ S  +L W  QIA GM+YL +  ++HRDLAARNVLV   ++++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP I T++VYM+M+KCW+ D   RP F ELVS F +  + P+RF+ + +E +    P D
Sbjct:  466 LALIHRNTHLCFVNTVP--WDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEADQCEACAHYK-------DSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQKIR----------KYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETEL---RKLKVLGSGAFGTVYKGIW-IP--DGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLT-STVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMD 1002          

HSP 2 Score: 123.635 bits (309), Expect = 9.933e-28
Identity = 162/657 (24.66%), Postives = 262/657 (39.88%), Query Frame = 1
Query:  124 FNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNH-----------SENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHI-FGMDSKDKL-----RYTVGGLCTSQCPASLLD-QNKICVYECDFDAHQKIG----NRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKN---GVTVPMLYHHLK---NVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNG-TCYLDRIPWEEI--SPDNRVKFSCNK----------TCDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCR-----QNCTGPTPKNCGGQCRYAIEENTCVKNC------SIDFFPVANNVNAPITCQLCHSSC 1926
             +P     ++C  ++     + PA   T+L     L Q C  + GNL ++ L      ++  LSFL+ I E+ G + I +N VK +PL  L+++RG  L  +  AL ++ N                  L E+ LR+L  I+   V+I  NP L Y +  L W  +L     Q   V      S     C   C         +   C+G S  +CQ  T  +       CK    G +P   C  +CA GC G    DC  C        C   C   P  I +  D+ + +     RYT G  C + CP + L  +   C   C  +  +        RC +C +  C     G  + ++        +  R  ++    + +   C  I G L     SF+ N   GV  P+   HL+    + EI G   +  +     +L+   NL  IR  +  H  A ++ + G  I  LGL+ L+++   +++   N   C+++ +PW+++  +P   +  S N+           C+ LC  G CWGPG   C +C+ +  G  CV++C    G        K   C  CHP C+     + C G     C   C +  + ++CV  C       + + P+    +    CQ C  +C
Sbjct:   16 LSPGAAGTQVCTGTDM--KLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLP-----ANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVL-WKDVLRK-NNQLAPVDMDTNRSRACPPCAPTC---------KDNHCWGESPEDCQILTGTICTSGCARCK----GRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHC---PALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKC-SKPCAGVCYGLGMEHL--------RGAR--AITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVA-PLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRIL-HDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVRGK--HCLPCHPECQPQNSSETCYGSEADQCEA-CAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINC 631          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771])

HSP 1 Score: 261.151 bits (666), Expect = 3.225e-70
Identity = 169/547 (30.90%), Postives = 268/547 (48.99%), Query Frame = 1
Query: 2020 IKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEP--CHSMCRT--CSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR---NGCLLANDSTA--CTRCLNHK---------------------LFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFI--ILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            I   +N  LC+  +       S INQ I           + E   C+ +C    C G   ++  C  C+ +     C++ C+       + E G  C +C  +C    +G L  +      CT+C + K                      + D D+    C   C    N     D  +       T+    R  +    ++ G F  ++  + F V   R    + R L   + L +   EP   +         PN  +++++  ++L      K LGSGAFG VY+G W VP  + + + + V IK+++ ++    + EF++EA IMAS+ H H + L+GVCLS     LV+    HG L  Y+ ++   I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++++ITDFGLARL++  +       GK+PI+W+A+E +    ++  +DVW+YGVT+WE+ T+  +PY+ + T EI   L++G RL QP I T++VYMVM+KCW+ D   RP F EL + F +  + P+R+L +
Sbjct:  458 IYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQ--CLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALR--RFLETELVEPLTPSGTA------PNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VP--EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVI 987          

HSP 2 Score: 146.747 bits (369), Expect = 9.080e-35
Identity = 145/577 (25.13%), Postives = 230/577 (39.86%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQ------KIGNRCIE-CP---NGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEISP---------DNRVKFSCNK---TCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ------NCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANN-----VNAPITCQLCHSSCFVDKTLVGTNHACTGPSN 1980
            N  + +PL NL++IRG  L  +  AL I  N+ ++G F L+E+ L+NL  I++  V + QN  L Y +  + W  I+ +P    + +      S+G  +CH  C          +  C+GP++N CQ  T+ V  +      +       C  ECAGGC G    DC  C        CV+ C     +    F ++     +YT G  C  +CP + +  +  CV  C     +      K+   C + CP   +G    S    +  + + IDKF   N  K  +N   +  +T          I    +N      P   +  + VREI G  ++ ++   +++ +  SNL  I   V    ++  +               +   G I I   +  CY   I W  +           DNR   +C      C+ LC+   CWGPG + C SC  +  G  C++ C+   G F  + E  +I C  C   C +       C GP P NC  +C +  +   CV+ C  D    AN+      +    C  CH +C            C GP++
Sbjct:   92 NQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYAD-TIHWQDIVRNPWPSNMTLVS-TNGSSGCGRCHKSC----------TGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFI--NCTK--INGNLIFLVTG---------IHGDPYNAIDAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEF-REFENGSI-CVECDSQCEKMEDGLLTCHGPGPDNC-TKCSHFKDGPNCVEKCP-DGLQGANSFIFKYADQDRECHPCHPNC---------TQGCNGPTS 630          

HSP 3 Score: 53.5286 bits (127), Expect = 2.548e-6
Identity = 29/77 (37.66%), Postives = 40/77 (51.95%), Query Frame = 1
Query: 1582 CNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDS---PGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNC 1803
            C K  D L T  C GPG + C  C+++K G +CV++C D       F  +   +  +C  CHP C Q C GPT  +C
Sbjct:  559 CEKMEDGLLT--CHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDC 633          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771])

HSP 1 Score: 261.151 bits (666), Expect = 3.296e-70
Identity = 169/547 (30.90%), Postives = 268/547 (48.99%), Query Frame = 1
Query: 2020 IKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEP--CHSMCRT--CSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR---NGCLLANDSTA--CTRCLNHK---------------------LFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFI--ILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            I   +N  LC+  +       S INQ I           + E   C+ +C    C G   ++  C  C+ +     C++ C+       + E G  C +C  +C    +G L  +      CT+C + K                      + D D+    C   C    N     D  +       T+    R  +    ++ G F  ++  + F V   R    + R L   + L +   EP   +         PN  +++++  ++L      K LGSGAFG VY+G W VP  + + + + V IK+++ ++    + EF++EA IMAS+ H H + L+GVCLS     LV+    HG L  Y+ ++   I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++++ITDFGLARL++  +       GK+PI+W+A+E +    ++  +DVW+YGVT+WE+ T+  +PY+ + T EI   L++G RL QP I T++VYMVM+KCW+ D   RP F EL + F +  + P+R+L +
Sbjct:  458 IYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQ--CLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALR--RFLETELVEPLTPSGTA------PNQAQLRILKETEL---KRVKVLGSGAFGTVYKGIW-VP--EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVI 987          

HSP 2 Score: 146.747 bits (369), Expect = 8.665e-35
Identity = 145/577 (25.13%), Postives = 230/577 (39.86%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQ------KIGNRCIE-CP---NGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEISP---------DNRVKFSCNK---TCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ------NCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANN-----VNAPITCQLCHSSCFVDKTLVGTNHACTGPSN 1980
            N  + +PL NL++IRG  L  +  AL I  N+ ++G F L+E+ L+NL  I++  V + QN  L Y +  + W  I+ +P    + +      S+G  +CH  C          +  C+GP++N CQ  T+ V  +      +       C  ECAGGC G    DC  C        CV+ C     +    F ++     +YT G  C  +CP + +  +  CV  C     +      K+   C + CP   +G    S    +  + + IDKF   N  K  +N   +  +T          I    +N      P   +  + VREI G  ++ ++   +++ +  SNL  I   V    ++  +               +   G I I   +  CY   I W  +           DNR   +C      C+ LC+   CWGPG + C SC  +  G  C++ C+   G F  + E  +I C  C   C +       C GP P NC  +C +  +   CV+ C  D    AN+      +    C  CH +C            C GP++
Sbjct:   92 NQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYAD-TIHWQDIVRNPWPSNMTLVS-TNGSSGCGRCHKSC----------TGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFI--NCTK--INGNLIFLVTG---------IHGDPYNAIDAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEF-REFENGSI-CVECDSQCEKMEDGLLTCHGPGPDNC-TKCSHFKDGPNCVEKCP-DGLQGANSFIFKYADQDRECHPCHPNC---------TQGCNGPTS 630          

HSP 3 Score: 53.5286 bits (127), Expect = 2.664e-6
Identity = 29/77 (37.66%), Postives = 40/77 (51.95%), Query Frame = 1
Query: 1582 CNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDS---PGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNC 1803
            C K  D L T  C GPG + C  C+++K G +CV++C D       F  +   +  +C  CHP C Q C GPT  +C
Sbjct:  559 CEKMEDGLLT--CHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDC 633          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Mouse
Match: Egfr (epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294])

HSP 1 Score: 254.988 bits (650), Expect = 1.721e-68
Identity = 160/509 (31.43%), Postives = 262/509 (51.47%), Query Frame = 1
Query: 2149 CHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACT-----RCLNHKLFVDDDKNKFSCVTRCP------HDRNFTEYQDGDFIC---------------LKFEETINSKQRKTIFIILSGCFGFLVFIIGFCV---LYFRWR-----ANQTRILAE---IKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            C+ +C +      E R C  C+      +CV++C+ ++    +     EC QCH EC    L    +  CT      C+    ++D       CV  CP      ++    +Y D + +C               L+  E   S  +  I  I +G  G L+FI+   +   L+ R R         R+L E   ++ L  + + P+  +++   I +    +++++              LGSGAFG VY+G W +P  + + + + V IK +  + S  +  E L+EA +MASV + H   L+G+CL+     L++    +G L  Y++++   I S  +L W  QIA GM YL  R ++HRDLAARNVLV    +++ITDFGLA+L+   +     + GKVPI+W+A+E++L   Y+  +DVW+YGVT+WE+ T+  +PY+ +   +I S L++G RL QP I T++VYM+M+KCW+ D   RP F EL+  F +  + P+R+L +
Sbjct:  506 CNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPEC----LPQAMNITCTGRGPDNCIQCAHYIDGPH----CVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPK--IPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLR---ILKETEFKKIKV--------------LGSGAFGTVYKGLW-IP--EGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLT-STVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVI 983          

HSP 2 Score: 180.644 bits (457), Expect = 3.555e-45
Identity = 165/587 (28.11%), Postives = 245/587 (41.74%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPAS-LLDQNKICVYECD---FDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTV-----PMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKF----------SCNKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCS---DSPGYFASQTEFKTIKCQTCHPLCRQN-----CTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNV-----NAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGC 2001
            N V+RIPL NL++IRG  L     AL I+ N+  N T L E+ +RNL+ I+   V  S NP L  ++  + W  I+ +     + +     PS+   KC   C   +         C+G  +  CQK TK +  +    C     G  P   C ++CA GC G    DC VC K   ++ C  +C P   +    + MD   + +Y+ G  C  +CP + ++  +  CV  C    ++  +    +C +C +G C       K+CN   I +F        S+N   +     CT I GDL I  ++F  +  T      P     LK V+EI G   +  +    ++L    NLE IR   K H   S   +             +   G + I G    CY + I W+++  +P+ + K           + N  C+PLC+ + CWGP    C SC     G  CV++C+     P  F   +E     C  CHP C        CTG  P NC  QC + I+   CVK C        N +     +A   C LCH++C          + C GP    G  GC
Sbjct:   94 NTVERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMD-TIQWRDIVQNVFMSNMSMDLQSHPSS-CPKCDPSCPNGS---------CWGGGEENCQKLTKIICAQQ---CSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKC-DGPCR------KVCNGIGIGEF----KDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSE-----CIQCHPECLPQAMNITCTGRGPDNC-IQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANC---------TYGCAGP----GLQGC 636          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Mouse
Match: Erbb3 (erb-b2 receptor tyrosine kinase 3 [Source:MGI Symbol;Acc:MGI:95411])

HSP 1 Score: 237.654 bits (605), Expect = 8.393e-63
Identity = 153/506 (30.24%), Postives = 240/506 (47.43%), Query Frame = 1
Query: 2149 CHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCLLANDST--ACTRCLNHKLFVDDDKNKFSCVTRCPHD----------------------RNFTEYQDGDFI--CLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEP----DMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHN-SSKGSTDEFLEEAKIMASVSHRHCLPLIGVCL--SLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            C  +C +          C  C+ Y  +  CV  C+ ++    +      C  CH EC+   G    N S   AC RC + +       +   CV  CPH                        N T+   G  +  CL   E + SK    I + +     FL  I+G   LY+R R  Q +             EP    +  N     I +   +R++++              LGSG FG V++G W +P  + + I + V IKVI + S + S     +    + S+ H H + L+G+C   SL+   LV+ Y   GSL  +++Q+ + +    +L W  QIA GM YL +  ++HRDLA RNV++     +Q+ DFG+A L+   D  ++    K PI+W+A+E++    Y+  +DVW+YGVT+WE+ T+   PY  L   EI   L++G RL QP+I T++VYMVM+KCW+ D ++RP+F EL + F +  + P R+L +
Sbjct:  500 CDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFR-------DGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVLMSKPHLVIAVTVGLTVIFL--ILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKV--------------LGSGVFGTVHKGIW-IP--EGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQ---LVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVI 976          

HSP 2 Score: 138.658 bits (348), Expect = 3.376e-32
Identity = 161/627 (25.68%), Postives = 250/627 (39.87%), Query Frame = 1
Query:  229 LGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGT--AKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP----NHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQ--KIGNRCIE-----CPNGNCNSSTAG--YKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEI---RLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI---SPDNRVKFSCN----------KTCDPLC-TGQCWGPGNEMCYSCAYYKAGNSCVKQCS---DSPGYFASQTEFKTIKCQTCHPLCR-----QNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFF----PVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGP 1974
            L ++C  + GNL I        G + DLSFL+ I E++G + +  N+   +PL NL+V+RG  + +   A+ ++ N++ N +  L ++    L  I+   V I +N  L +++  +DW  I+  P       +E V  +NG     CH  C+            C+GP   +CQ  TK +         F       C  ECAGGC G    DC  C        CV  C P P       F ++    ++Y  GG+C + CP + +     CV  C  D  +  K G +  E     CP   C  + +G  Y+  + + ID F   N  K   N   L+   N              ++K     P   +  + VREI G  ++ ++   + N +  SNL  I    L  +  ++    N++   + F  LK++    G++ I      CY   + W  +     + R+    N          K CDPLC +G CWGPG   C SC  Y     CV  C+     P  F  +       C +CHP C+       C G     C  +C +  +   CV +C         P+    +A   C+ CH +C            C GP
Sbjct:   52 LYEKCEVVMGNLEI-----VLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHMD-TIDWRDIVRVPD------AEIVVKNNGGNCPPCHEVCK----------GRCWGPGPEDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRC-PAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKA-CEGTGSGSRYQTVDSSNIDGFV--NCTKILGNLDFLITGLN-----------GDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISA--GRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAH-----CFSCHPECQPMEGTSTCNGSGSDAC-ARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENC---------TQGCKGP 624          
BLAST of epidermal growth factor receptor 3 vs. UniProt/SwissProt
Match: sp|P0CY46|EGFR_APIME (Epidermal growth factor receptor OS=Apis mellifera OX=7460 GN=Egfr PE=2 SV=1)

HSP 1 Score: 448.743 bits (1153), Expect = 1.201e-132
Identity = 317/1060 (29.91%), Postives = 485/1060 (45.75%), Query Frame = 1
Query:  565 KNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQK--QTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTV-PMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPW---------EEISPDNRVKFSCNK---TCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLC--HKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKN----KFSCVTRC-PHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGF-LVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP----PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHE-YVNQQYPKDEDQREMIQLNQISIDS 3645
            + ++W +I+  P+     V  F  P      C   CE          Q C+G     CQK  +T C        C F       C   CAGGC G    DC  C     D  C   C P   +    +  +     +Y  G  C  +CP  LL  N  CV  C     + +   C+ C +G C  +  G +  +   ID F      K     +  + + + +         + SF K    + P        ++EI G  ++        NL++  NLE I     +   AS   +    + F      K   G I+I      CY   I W         E +  +NR +  C K    CD  C+ + CWGPG   C SC  +  GN C++ C+ +PG +  Q + KT  C+ CH  C  +C GP   +C  +C++A +   CV  C       A+  N    C+ CH +C      VG    C GP N +G  GC  C+K I  ++    C   K SCP G+Y   ++       K +  ++ C  CHS C+ C+G    + +C +C  Y    +C  EC          +    C  C  ECR GC        C +C N+K+++D+D +     F+C   C P   +     D +  C    ET    + +    IL+G   F L F++   ++ + WR         +K   +      +  + ++   RP    PN+ ++++I   ++        LG GAFG VY+G W VP  +N  + + V IKV+H+ +  +T  EFL+EA IMASV H + L L+ VC++ +   LV+     G L  ++++   KI S ++L W  QIA GMAYL +R ++HRDLAARNVLV   + ++ITDFGLA+L+D  ++      GK+PI+WLA+E +    ++  +DVWA+GVT+WE+ TY  RPYE +    +   L++G RL QP I T++VYM+MIKCW+ D   RPSF EL   F +  + P R+L +  + Y+       +D++EMI+    ++D 
Sbjct:   11 RTINWEEIITGPSAMYSYVYNFTSPERACTPCDKSCE----------QGCWGEGPENCQKYSKTNCSPQCWQGRC-FGPNPRECCHLFCAGGCTGPKQSDCIACKNFFDDGVCTQECPPMQKYNPTTYSWEPNPDGKYAYGATCVRRCPEHLLKDNGACVRSCP-PKKKALNGECVPC-DGPCPKTCKGVEKVHSGNIDSF------KDCTIIEGSITILDQSFQGFQHVYRNFSFGKRYEKMHPDKLEVFSTLKEITGFLNIQGDHKDFKNLSYFRNLEVIGGRTLTEYFASLYVVKTSLVSFGLSSLKKIYSGSIAILENKNLCYAQSINWTRIKKSSEHESLLSNNRNESECIKDGLVCDEQCSDEGCWGPGPAQCLSCKNFILGNDCLQDCT-APGIY--QADEKT--CKVCHEECDGSCIGPNTDHCK-KCKHARDGPFCVPECP------ASKYNDNGVCKSCHGNC------VG---GCEGPENNIGPNGCHSCDKAILNDHVPEGCLQKKESCPDGYYYEWVSPLEQGPLKPLASKAVCRKCHSRCKKCTGYGFHEHVCQECTKYKRGEQCEDECP----ADYFADANKLCIPCFSECR-GCF-GPGPNQCYKCRNYKIYIDEDTDGNTTSFNCTETCTPEYPHKIFNPDSEPYCSL--ETAGLIENELQPAILAGVAVFALAFLVVAAIIMYFWRVRAKAKENTVKMTMA------LTGLDDNEPLRPTGVKPNLAKLRIIKEEEM---RKGGILGYGAFGNVYKGVW-VPEGEN--VKIPVAIKVLHDGTGANTSKEFLDEAYIMASVEHPNLLQLLAVCMTSQM-MLVTQLMPLGCLLDFVRRFKDKIGSKALLNWCTQIARGMAYLEERRLVHRDLAARNVLVQTPNCVKITDFGLAKLLDINEEQYKAAGGKMPIKWLALECIQHRVFTHKSDVWAFGVTIWEVLTYGGRPYENVPARNVPELLEKGERLPQPAICTIDVYMIMIKCWMLDAESRPSFKELAEDFAKMSRDPGRYLAIKGDKYMRLPSYTLQDEKEMIRNLASAMDG 1009          
BLAST of epidermal growth factor receptor 3 vs. UniProt/SwissProt
Match: sp|P24348|LET23_CAEEL (Receptor tyrosine-protein kinase let-23 OS=Caenorhabditis elegans OX=6239 GN=let-23 PE=1 SV=3)

HSP 1 Score: 449.514 bits (1155), Expect = 1.221e-132
Identity = 369/1233 (29.93%), Postives = 563/1233 (45.66%), Query Frame = 1
Query:  367 DVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVS----EFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP--CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP--NH-----IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFS--LVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIH--GKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI----SPDNRVKFSC------------NKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENT-------CVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGF--YQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCV-KECDNMKNVTIKLEIGDECP---------------QCHKECRNGCLLAN-DSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIIL-SGCFGFLVFIIGFCVLYFR-WRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQIS--IDSDFRPI------SIRNIKSDETSWAAATLQ-----------NDSAYH---LINNSYSKESDKSFLPKRKKAKRNISL 3813
            ++++I    L+VI G  + ++ +AL I  N       + E+ +R LR I + +V I  NP + Y+   +DW ++L DP  QK++ +       +     AKCH  C          +  C+G   N+CQ+  + V  K    C ++ +      C   C GGC G   K+C  C+K   D  C+ +C  R   NH     +F  D     RY  G  C  +CP  LL +N +CV  C    H        EC    C SS+       I T+D           L  +TL  L  C  I G L           +     Y  LK V E + + S  +   Q    +L FL NL+ I    K H V  A+ I+      E           G + I   +  CY+ +I W  I      DN+   +              + CD  C  + CWG   E C  C  +K+  +CV++C D+ G+  +QT   ++KC+ C P C + C G    +C   CR+    N+       CV +C +  FP   NV     C+ CH +C+        ++ CTGP + LG GGC +C+  +K  N+   C + S          + N  IS      V ++ CE C   C+TCS +              + NKCV K  +   N + ++ + D+CP               +CH EC      AN  ST C +C N  +F  D      CV+ CP +  F+   +G+  CL ++  I S+QRKT  +I+ S  FGF V  +   ++Y+R  R  +   +AE+          DM  +     +  PNM R+ +IP S+L      K LG+GAFG V+ G +   R  N  + + V IKV   + +  TDE LEEA  M  + H + L +IG C+  +   +V+ Y   G+L  +L+ + + + +   + +  QIA GM YL K+ ++HRDLA RNVLV   ++++ITDFGL++++    DSI IKSGKV I+WLAIE      Y+ A+DVWA+GVT WEI T+ + PY+ ++T  I +FL+ GNRL QP   + ++Y  +++CW+ DP  RP F  L   F++F + P+ FL    E  N+    D    E  Q  +I    D +  P       S+ ++ S  TS A  T+            N S Y        S ++E +   +PK K+ +++  L
Sbjct:  125 NIQKISFPRLRVIYGDEVFHD-NALYIHKNDK-----VHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC----------NDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDG----RYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEK--CRSSSCP----KICTVDGH---------LTNETLKNLEGCEQIDGHLI----------IEHAFTYEQLK-VLETVKIVSEYITIVQQNFYDLKFLKNLQIIE-GRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQT---SMKCERCSPEC-ETCNGLGELDCL-TCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNV-----CEKCHPTCY--------DNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRN----------VVQNKCVCKHVEYQPNPSERICM-DQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQ---CVSECPKNLPFSNPANGE--CLDYD--IASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEM---------VDMPELTPIDASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYPKRAKN--VKIPVAIKVFQ-TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL----ENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVL 1256          
BLAST of epidermal growth factor receptor 3 vs. UniProt/SwissProt
Match: sp|P04412|EGFR_DROME (Epidermal growth factor receptor OS=Drosophila melanogaster OX=7227 GN=Egfr PE=1 SV=3)

HSP 1 Score: 423.705 bits (1088), Expect = 6.728e-123
Identity = 314/1129 (27.81%), Postives = 515/1129 (45.62%), Query Frame = 1
Query:  367 DVKRIPLTNLKVIRGVTL-----RNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTV-PMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEI--RLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSCNKTCD------PLCTGQC-----WGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNN---NQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKEC--DNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNK------FSCVTRCPHDRNFTEYQ---DGDFICLKFEET--INSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIK-VIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHE-YVNQQYPKDEDQREMIQ 3621
            DVK++    L++IRG TL       E  AL + ++       +  +++ +LR +++  V    N  L ++ + + WS+I+ + T       +F  P     KCH  C          +  C+G     CQK +K  C        C   K  E  C   CAGGC G T KDC  C     ++     C P   +    + +++  + +Y  G  C  +CP  LL  N  CV  C  D   K G  C+ C NG C  +  G  + +   ID F  +N      N + L Q    T         + +     + + P        V+EI G  ++     +  NL++  NLE I  R  ++S   A A+ +             +   G + I      CY+  I W  I   P+ +V  + N   D       +C+ QC     WG G + C +C  +    +C+  C    GY ++  +F    C+ CHP CR  C G    +C  +C +  +   CV  C        N  N    C+ CH++C            CTGP + +G G C+ C   I  N+    + L     CP G++   ++       K +  ++ C  CH +C  C+     +++C +C  Y    +C  EC  D+  +     E   EC Q H EC NGC     +  C  C N KLF  ++         F+C ++CP +     YQ    G +       +  I +     +  I++G    +  I   CV+ +  R  Q      +K   +     D + ++   I    N+ +++++  ++L        LG GAFG+VY+G W VP  +N  + + V IK ++ ++   S++EFL EA IMAS  H + L L+ VC+S +   L++     G L  Y++ N  KI S ++L W+ QIA GM+YL ++ ++HRDLAARNVLV     ++ITDFGLA+L+    +      GK+PI+WLA+E + +  ++  +DVWA+GVT+WE+ T+ +RP+E +   +I   ++ G +L QPEI +L++Y  ++ CW  D  MRP+F +L + F +F + P R+L +P + +        +D++++I+
Sbjct:  167 DVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSK------MYTLEIPDLRDVLNGQVGFHNNYNLCHM-RTIQWSEIVSNGTDAYYNY-DFTAPERECPKCHESC----------THGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPREC-CHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDK-GGECVPC-NGPCPKTCPGVTVLHAGNIDSF--RNCTVIDGNIRILDQ----TFSGFQDVYANYTMGPRYIPLDPERREVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAI-VKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAYKFDNRTCKICHPECR-TCNGAGADHCQ-ECVHVRDGQHCVSECP------KNKYNDRGVCRECHATC----------DGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTD-----EEQRECFQRHPEC-NGCT-GPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAV-LVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIG--ANLCKLRIVKDAEL---RKGGVLGMGAFGRVYKGVW-VPEGEN--VKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIR 1228          
BLAST of epidermal growth factor receptor 3 vs. UniProt/SwissProt
Match: sp|P13388|XMRK_XIPMA (Melanoma receptor tyrosine-protein kinase OS=Xiphophorus maculatus OX=8083 GN=xmrk PE=2 SV=2)

HSP 1 Score: 275.404 bits (703), Expect = 2.908e-74
Identity = 162/479 (33.82%), Postives = 249/479 (51.98%), Query Frame = 1
Query: 2197 MCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTAC-----TRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQ-------RKTIFIILSGCFGFLV----FIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            MC  C       +CV  C+ ++    + ++   C QCH+EC    L+  DS  C       C     F D  +    C+ RCPH        DGD +  K+ + +   Q       +      LSGC G +V      +G              I+  ++      K      ++E  +  P       PN   ++++  ++   D   + LGSGAFG VY+G W     D + I + V IKV+  ++    + E L+EA +MASV H H   L+G+CL+     LV+    +G L  Y++Q+ ++I    +L W  QIA GM YL +R ++HRDLAARNVL+ + ++++ITDFGL++L+   +       GKVPI+W+A+E++L  TY+  +DVW+YGVT+WE+ T+  +PY+ +   EI S L+ G RL QP I T+EVYM+++KCW+ DP  RP F ELV  F Q  + P R+L +
Sbjct:  520 MCVSCLHVDRGGRCVASCNLLQGEPREAQVDGRCVQCHQEC----LVQTDSLTCYGPGPANCSKSAHFQDGPQ----CIPRCPHGI----LGDGDTLIWKYADKMGQCQPCHQNCTQGCSGPGLSGCRGDIVSHSSLAVGLVSGLLITVIVALLIVVLLRRRRIKRKRTIRCLLQEKELVEPLTPSGQAPNQAFLRILKETEFKKD---RVLGSGAFGTVYKGLWN---PDGENIRIPVAIKVLREATSPKVNQEVLDEAYVMASVDHPHVCRLLGICLT-SAVQLVTQLMPYGCLLDYVRQHQERICGQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHVKITDFGLSKLLTADEKEYQADGGKVPIKWMALESILQWTYTHQSDVWSYGVTVWELMTFGSKPYDGIPAKEIASVLENGERLPQPPICTIEVYMIILKCWMIDPSSRPRFRELVGEFSQMARDPSRYLVI 979          

HSP 2 Score: 140.584 bits (353), Expect = 4.271e-32
Identity = 153/585 (26.15%), Postives = 246/585 (42.05%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGT-------FLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKD-----KLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQ--KIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFN-----KNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXV-YGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSC---NKTCDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLC-----RQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNV-----NAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGC 2001
            N+V  IPL NL++IRG  L      L ++ N+ +N +        L+++ L NL  I+S  V +S NP L  +E  ++W  I+D  +   + +     P     +C  +C++     G  +  C+ P    CQK TK +  +    C     G  P   C+  CAGGC G  + DC  C     D  C  +C P    I+ + S        ++YT G  C  +CP++ +     CV  C     +  + G R  +  +G C       K+C+   I       +   ++N   +   +NCT I GD+ ++  SF      K G   P    +L  V+EI G   ++ +   +++L+   NLE IR         S + +  +++++LGL+ LK+V  G + +  T    Y + I W  +  S D  +++     N+TC+  C+   CWGPG  MC SC +   G  CV  C+   G    +      +C  CH  C        C GP P NC     +  +   C+  C        + +     +    CQ CH +C            C+GP    G  GC
Sbjct:   92 NEVSTIPLVNLRLIRGQNLYEGNFTLLVMSNYQKNPSSPDVYQVGLKQLQLSNLTEILSGGVKVSHNPLLCNVE-TINWWDIVDKTSNPTMNLI----PHAFERQCQ-KCDH-----GCVNGSCWAPGPGHCQKFTKLLCAEQ---CNRRCRGPKPIDCCNEHCAGGCTGPRATDCLACRDFNDDGTCKDTCPPP--KIYDIVSHQVVDNPNIKYTFGAACVKECPSNYVVTEGACVRSCSAGMLEVDENGKRSCKPCDGVCP------KVCDGIGIGSL----SNTIAVNSTNIRSFSNCTKINGDIILNRNSFEGDPHYKIGTMDPEHLWNLTTVKEITGYLVIMWWPENMTSLSVFQNLEIIRGRTTFSRGFSFVVVQVRHLQWLGLRSLKEVSAGNVILKNTLQLRYANTINWRRLFRSEDQSIEYDARTENQTCNNECSEDGCWGPGPTMCVSCLHVDRGGRCVASCNLLQG--EPREAQVDGRCVQCHQECLVQTDSLTCYGPGPANCSKSAHFQ-DGPQCIPRCPHGILGDGDTLIWKYADKMGQCQPCHQNC---------TQGCSGP----GLSGC 634          
BLAST of epidermal growth factor receptor 3 vs. UniProt/SwissProt
Match: sp|Q60553|ERBB2_MESAU (Receptor tyrosine-protein kinase erbB-2 OS=Mesocricetus auratus OX=10036 GN=ERBB2 PE=2 SV=1)

HSP 1 Score: 272.322 bits (695), Expect = 5.512e-73
Identity = 174/564 (30.85%), Postives = 279/564 (49.47%), Query Frame = 1
Query: 2017 LIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCE----PCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR----NGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPH----DRNFT---EYQDGDFICLKF------------EETINSKQRK----TIFIILSGCFGFLVFIIGFCVLYFRWRA-----NQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKD 3597
            L+  + N +LC   + P  + Q   N + + LH     +  C      C+ +C            C  C  +    +CVKEC   K +  +   G  C  CH EC+          +++  CT C ++       K+   CV RCP     D ++    +Y D + +C               E    ++QR     +I   + G   FLV  +   +L  R R         R+L E + +        M N  +  I +   +R++++              LGSGAFG VY+G W +P  D + + + V IKV+  N+S  +  E L+EA +MA +   +   L+G+CL+     LV+    +G L  +++++  ++ S  +L W  QIA GM+YL    ++HRDLAARNVLV   ++++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP I T++VYM+M+KCW+ D   RP F ELVS F +  + P+RF+ + +E +    P D
Sbjct:  465 LVLIHRNTHLCFVHTVP--WDQLFRNPHQALLHSGNPSEEECGLKDFACYPLCAHGHCWGPGPTQCVNCSHFLRGQECVKECRVWKGLPREYVNGKHCLPCHPECQPQNSTETCTGSEADQCTACPHY-------KDSPFCVARCPSGVKPDLSYMPIWKYPDEEGMCQPCPINCTHSCVDLDERGCPAEQRASPATSIIATVVGILLFLVIGVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKV--------------LGSGAFGTVYKGIW-IP--DGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGLGSPYVSRLLGICLT-STVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWIALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPLD 1001          

HSP 2 Score: 120.939 bits (302), Expect = 6.034e-26
Identity = 155/649 (23.88%), Postives = 254/649 (39.14%), Query Frame = 1
Query:  124 FNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNH----------SENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLD-QNKICVYECDFDAHQKIG----NRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKN---GVT--VPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXV-YGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSCNKT----------CDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCR-----QNCTGPTPKNCGGQCRYAIEENTCVKNCS------IDFFPVANNVNAPITCQLCHSSC 1926
             +P     ++C  ++     + PA   T+L     L Q C  + GNL ++ L      ++  LSFL+ I E+ G + I ++ V+ +PL  L+++RG  L  +  AL ++ N                 L E+ LR+L  I+   V+I  NP L Y +  L W  +      Q   V      S     C   C         +   C+G S  +CQ  T  +  + +   +     +  C  +CA GC G    DC  C        C   C     +    F      + RYT G  C + CP + L  +   C   C  +  +        RC +C       S +  ++C    ++    +  R  ++    + +   C  I G L     SF+ N   G+    P      + + EI G   +  +   + +L+   NL  IR  V  H  A ++ + G  I +LGL+ L+++  G + I      C++  +PW+++  +P   +  S N +          C PLC  G CWGPG   C +C+++  G  CVK+C    G        K   C  CHP C+     + CTG     C   C +  +   CV  C       + + P+    +    CQ C  +C
Sbjct:   16 LSPGASGTQVCTGTDM--KLRLPASPETHLDIVRHLYQGCQVVQGNLELTYLP-----ANATLSFLQDIQEVQGYMLIAHSQVRHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTATGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDTVL-WKDVFRK-NNQLAPVDIDTNRSRACPPCAPAC---------KDNHCWGASPEDCQTLTGTIAPRAVPAARARLPTDC-CHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPLNNQEVTAEDGTQRCEKC-------SKSCARVCYGLGMEHL--RGAR--AITSANIQEFAGCKKIFGSLAFLPESFDGNPSSGIAPLTPEQLQVFETLEEITGYLYISAWPDSLHDLSVFQNLRVIRGRVL-HDGAYSLALQGLGIRWLGLRSLRELGSGLVLIHRNTHLCFVHTVPWDQLFRNPHQALLHSGNPSEEECGLKDFACYPLCAHGHCWGPGPTQCVNCSHFLRGQECVKECRVWKGLPREYVNGK--HCLPCHPECQPQNSTETCTGSEADQCTA-CPHYKDSPFCVARCPSGVKPDLSYMPIWKYPDEEGMCQPCPINC 630          
BLAST of epidermal growth factor receptor 3 vs. TrEMBL
Match: A0A1B1ACX9 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 2972.96 bits (7706), Expect = 0.000e+0
Identity = 1469/1469 (100.00%), Postives = 1469/1469 (100.00%), Query Frame = 1
Query:   64 MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEISPDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISLERIKNFSKFDLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQRSNEYDTQPVNPQIAKLRKEIKHNNSLYDGSSKSDNTFKIPERIFIDKSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNPQFESIKSSVGNRIENSPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAVLNKEYIDDDGYLEPKKFDR 4470
            MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTLILGDLDIDDISFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFLGLKKLKKVYGKISIGGTNGTCYLDRIPWEEISPDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISLERIKNFSKFDLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQRSNEYDTQPVNPQIAKLRKEIKHNNSLYDGSSKSDNTFKIPERIFIDKSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNPQFESIKSSVGNRIENSPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAVLNKEYIDDDGYLEPKKFDR
Sbjct:    1 MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTLILGDLDIDDISFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFLGLKKLKKVYGKISIGGTNGTCYLDRIPWEEISPDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISLERIKNFSKFDLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQRSNEYDTQPVNPQIAKLRKEIKHNNSLYDGSSKSDNTFKIPERIFIDKSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNPQFESIKSSVGNRIENSPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAVLNKEYIDDDGYLEPKKFDR 1469          
BLAST of epidermal growth factor receptor 3 vs. TrEMBL
Match: F6KBQ3 (Receptor protein-tyrosine kinase (Fragment) OS=Schmidtea mediterranea OX=79327 GN=egfr-3 PE=2 SV=1)

HSP 1 Score: 1956.03 bits (5066), Expect = 0.000e+0
Identity = 936/948 (98.73%), Postives = 943/948 (99.47%), Query Frame = 1
Query: 1627 PGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISLERIKNFSKFDLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQRSNEYDTQPVNPQIAKLRKEIKHNNSLYDGSSKSDNTFKIPERIFIDKSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNPQFESIKSSVGNRIENSPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAVLNKEYIDDDGYLEPKKFDR 4470
            PGNEMCYSCAYYKAGNSCVKQCS+SPGYFASQTEFKTIKCQTCHPLC QNCTGPTPKNCGGQCRYAI++NTC KNCSIDFFPVANNVNAPITCQLCHSSCFV+KTLVGTN ACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEET NSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKS LQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISLERIKNFSKF+LNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQRSNEY+TQPVNPQIAKLRKEIKHNNSLYDGSSKSDNTFKIPERIFIDKSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNP+FESIKSSVGNRIENSPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAVLNKEYIDDDGYLEPKKFDR
Sbjct:    1 PGNEMCYSCAYYKAGNSCVKQCSNSPGYFASQTEFKTIKCQTCHPLCXQNCTGPTPKNCGGQCRYAIKKNTCEKNCSIDFFPVANNVNAPITCQLCHSSCFVBKTLVGTNXACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETFNSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSLLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISLERIKNFSKFNLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQRSNEYNTQPVNPQIAKLRKEIKHNNSLYDGSSKSDNTFKIPERIFIDKSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNPKFESIKSSVGNRIENSPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAVLNKEYIDDDGYLEPKKFDR 948          
BLAST of epidermal growth factor receptor 3 vs. TrEMBL
Match: A0A1B1ACY2 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 755.747 bits (1950), Expect = 0.000e+0
Identity = 471/1239 (38.01%), Postives = 689/1239 (55.61%), Query Frame = 1
Query:   85 VVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRN--------LRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNK--DLKWCKF-TKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFG---MDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNK--NGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWE-EISPDNR---VKFSCNKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIK-------CQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLA-NDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDG---DFICLKFEETINSKQR-----KTIFIILSGCFGFLVFIIGFCVLYFRW--RANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQD---NKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDS---IVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRP 3657
            V+I + +      F+ +YP   IC  S   G       +  +LK  LG    CTH+ GNL I ++  + +    DL FL SIIE++G + + NN +K I L NLKVIRG          ++    SE   +++ +D  N        LR I + +V        ++L +++ W ++ ++P  QKL             +CH++C    R D     +C+  S N CQKQ+KCVK K  +++WC F  + GEI    C  +C GGC+G  + DC VC K V  + CV  C P   +  G   ++   KLR  VG +C + CP +LL +   C+Y C+     ++ N+CI C N    SS    K  NI  I     +N   + +    L   T+   ++G+      SF+K   G+T+PMLY HL NV+ I G   +      + NLTFL NL+EIR  + + + ++A+NI    +EFLGL+KL++++GK  +  + G CY D + W   I  +N+   +   CNK CD  C  Q CWGPG+ MCY+C  ++A  +CV +C D PG++ + +  K          CQ CHPLC QNCTGP P NC G CRY  E + CVKNCS  +F          TC  CH +C  +         CTG S+ILG GGCS C KLI   + ++ C+K  CP+ +Y + I+ +     +       C+PC   C  CSG+      C +C GY+  ++CVK+C     + + L     CP C+  C   C +  ND   C  C   +L++D+    F CV+ CP    + +++DG   D IC+   + ++ ++      K   IILS      VF+I    ++FR+  + NQ + +  +KA+YSN  EPD + + ++  T  PNM R+ +IP +DL+F+ ++KP+G+GAFG VYRG WK   +D   +   +L+V +KVI  +      E +EEAK+MASV H+HCL LIG+CL  E PCL++T+ + GSLDKYL+++   + S ++L W +QIADGM YL  RGIIHRDLA RNVL+ND + IQITDFGLA +V  T+D+   IVI  G+VPIRWLA+ETLL+  YS  TDVW++G+TLWEIFTY +RPY+EL   EI S+L QGNRL QPEI ++++Y +M +CW ++ + RPSF  L+ST   F Q P  +L +P++   +   KD+ +     L+QIS D    P
Sbjct:   10 VIILLESSLAIRQFDEEYPGVTICESSMTSGFQYFMPHSLMFLKGELGGNHNCTHVEGNLVIQNV--WPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQN--------SLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL----ITYNKYMEHQCHSDC---LRND---FPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLR--VGYMCANSCPVNLLQEVDACIYSCNSLHFYRVDNKCIRCQN----SSVCAKKEFNINKI--INEENEDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIR-HLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNK------TCIKCHETCMENDK---NQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQC---FPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKSFQCVSECPQTHKY-KHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSV---ITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKT-IPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRL----LSQISYDFQVYP 1198          
BLAST of epidermal growth factor receptor 3 vs. TrEMBL
Match: A0A1B1ACY5 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 693.345 bits (1788), Expect = 0.000e+0
Identity = 448/1203 (37.24%), Postives = 648/1203 (53.87%), Query Frame = 1
Query:   67 HLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAH-GSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVT--LRNEPDALNIIHNHSENG-TFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVK--NKDLKWCKFTKTGEIPC-SHECAGGCDGRTSKDCTVCNKLVKDSDCVSSC-APRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYI-----EFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI---------SPDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYF--ASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQ-NISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKL-EIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQ--DGDFICLKFEET---INSKQRKTIFI-ILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYIN-------LEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDET-DDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFL 3555
            +L+LF  +  I    N + F  +YP   IC        S  +  E    L  ++   + CTHI G++ I  +++ +  S       +SI EI G L I  ND+++I   NL++IRG     RN  D  +   +   +G   L ++D R+LR+I + NVI   NP ++YL  ++ W+++  DP  Q L      +      KC  +C+ W     V   FC+GPS N+CQ+QT C    + +   C++    E  C + +C GGC+G  +  CT C  ++ +  CV  C  P    I G  +  + RY  G  C+ QCPA +L +N  CV++C     +   N CI+C    C   T  +  CN+  I       N  Y L  Q L+QL NC  ILG + + + SF K+ +TV MLY +L  ++E+ G FS       + NLTFL NL   R +     + +  + H   I     EFLGLK LK++ G          CY++ IP  E+          P N     C+K C       CWGPGN++CY C  Y A  +CV  CS   G++   + +     KC  CHP C   C GP P  C   C+   E  TCV +CS +F+P  N+  A   C  CH +C    + +     CTGPS++ G GGC+KCE+++ +     +    +C +G Y    ++ +IS  +   V   +C PC  +C  C G + +   C  CKG +  N C   C   ++   K+ +    C  CH  C+ GC   +    CTRC N K+++D  K KF C   CP  ++  E +   GD +CL   E+   +   +R  I + ++      ++ +I   V+Y + +A   RI  E+KA YSN  EP+ K+  ED +++PPNM R+ ++   DL+F+  SKPLG GAFG VY+G WK+P+ +   +        L V IKVI N      +  ++EAK+MASVSH HCL  IGVCLS EKPCL+S Y + GSLDK+L +N  KI+S  ML W++QIADGM YL KR IIHRDLAARNVLV+  + +QITDFGL+++++ T D  I+IK+GKVPIRWLAIETL    YS  TDVWAYGVTLWEIFT+ K PYE+ AT +I  F+ +G RL QP+I +L+VY++M+ CWL+ P++RP F  L+ TF  + ++P R+L
Sbjct:    6 YLILF--LFLIQFQINNATFEEEYPGTIICQNDNVQIESLHSSVEKLKIL--SIIRSKNCTHIQGSIYILGITKLE--SKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQV---FCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMC---TNDHLPCNLFKIAGHTDGANDFY-LRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFK-DNHLKNLTFLRNLLRFRAAYLHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSNCTDKICHKDCS---EKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKA---CLPCHPNCSEYNSTI-----CTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYP--VTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPRDESYGTKIIDSISYCKTCHSSCK-GCY-GSTIFNCTRCKNKKIYLD--KKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHITVGVVVTMLILVIIVIVTIVVYLKRKAIAERIETELKARYSNLTEPNSKD--EDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYL 1174          
BLAST of epidermal growth factor receptor 3 vs. TrEMBL
Match: A0A0X3PH98 (Receptor protein-tyrosine kinase OS=Schistocephalus solidus OX=70667 GN=TR102389 PE=4 SV=1)

HSP 1 Score: 656.751 bits (1693), Expect = 0.000e+0
Identity = 446/1320 (33.79%), Postives = 657/1320 (49.77%), Query Frame = 1
Query:   61 NMHLLLFGVVIFISNICNGSNF----NPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPD----ALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQK-LKVS--EFVRPSN---GTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTG-EIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPR--PNHIFG-MDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYH-----HLKNVREIIGLFSL--VTFQTKISNLTFLSNLEEIRLSVKSH-TVASAMNIH-GKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEISPDNRVKFSCNKTCDP---------LCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYF-------------ASQTEFKTIK----------------------------------CQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSC---FVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQ-YLCHKGSCPKGFYQ----------SVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDN----MKNVTIKLE-------IGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICL---KFEETINSKQRKTIFIILSGC----FGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQD------NKYINLEVVIKVIHN---------SSKGST----------------------DEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDD-SIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            N H     + + +S    G +F     P+YPN +IC     +   KT  +    L+Y       CTHI GNL + +L R+ NGSDPDLSFL SI+E+SG + I NNDV+RIPLT+L++IRG+     P     AL I  N       LE +DLR L  I + NV +  NP L Y+   +D+  +  +P  Q+ L+VS  + +  S        CH  C    + D   + +C+GP K++CQ ++KC+ +   ++C          C   C GGC G +S +C  C   + +  C  SC P+   +H+    +   + +Y +  +C   CPA  L  + +CV ECDF     I   C  C    C             T ++ +  N     +      ++  C    G + ++ ++F K G     L       +L+N+REI+G   L       +++NLTFL NL ++        ++  A++I+    +EFLG K L+ V     +      CYL  +  ++I P          TCD          L    CWGPG  MC  C  ++AG+ CV  C D PG++             AS + F +++                                  C  CH  C Q C   +   C G C++  E N CV NCS +++      +    C LCH +C        L  +  AC+GP + LG GGC+ C  + K    Q + C    CP   Y           + +N +  +LH   +    C PCH +C  C G +  + +C +C+G+    +CV+ C +    M N    L           +C  CH++C  GC  A     C  C   K+ +D++ NKF C + CP D+ FT       +CL   K+E    +   +T   IL GC    FG  +  +   V  F ++A + +I   +K++Y+N   PDMK+      +R PNM R+++I   DL FD SS PLG+GAFG VYRG W+VP++        +  NL+V +KVI +         S K +T                      +E L EAK+MASVSH +CLPLIGVCL+    C+VS + + GS+D+YL++N   ++S+++L WA+QIADGMAYL  RGIIHRDLAARNVL+   +++QITDFGLA+++D  D+ S+V++SG+VPIRWLAIETL    YS  TDVW+YGVTLWEIFT+ K+PYE + T +IK  + +G RL QP+I TL+ YMVM+KCW++D   RP+F+EL+  F  F Q+P R+LY+
Sbjct:    2 NRHPFYLFLALLLST--GGKSFRFSLTPEYPNIKIC--RSRNVDCKTSLDPNIQLRYYRRQYSECTHILGNLVLCNLRRYDNGSDPDLSFLTSIVEVSGYVYISNNDVRRIPLTSLRIIRGMVPYYIPSLGNSALVISRNAFNKTVGLEVLDLRKLTVIQNHNVALWDNPQLCYIAFRVDFHALFPNPKQQEALRVSNSDLISQSGCDFDNTSCHPSC---VQTD--TNAYCWGPEKDQCQLRSKCLHDTS-RYCLMDGYNLGTTCDDACIGGCTGHSS-NCWACRDKLNNRTCTGSCPPKYILSHVTSRQELNPEFKYDLHDICVKTCPAPFLKMDTVCVIECDFKTTIPINGSCEPCATSPCAEH---------CTKEQIFGTNFPL--ITSAAAEKMKTCEYYSGPIYLNRMAFEKRGSGPAPLARLDDLWNLRNLREIVGYIYLDFTGSPPELTNLTFLQNLYKVTAEFSDGVSLGIALSIYNASNLEFLGFKSLRYVDTDAYLEFLPSLCYLSGL--KQILPMRTKAVKSPTTCDNEGHVCHSECLPITGCWGPGPAMCAHCCGFQAGDVCVSSCLDEPGFYTPPGLETQLVSVGASGSPFSSLQNAANIQCPTLPLTAAQLATMTAEEAISRVIPSPACARCHVECAQTCFNASNIACIGPCKHYKEANACVSNCSRNYYADETTKD----CLLCHPTCSNALQSTPLPVSVAACSGPGSYLGNGGCTFCHFIRKNPETQRFECLDRGCPPSHYGRPTHLSELKIAHVNLSPDNLHAATLDIRECAPCHPLCEVCEGPSTHETVCLKCRGWIYKGECVETCPSDDTYMPNENATLNEQELAALKAKQCLLCHRQCAGGCYAAGPED-CVNCRFRKILIDEESNKFVCNSTCPPDQPFT--MPNTNLCLDKIKYELISGAAATRTRNRILLGCSLGLFGVFLLALLIIVPCFHYKAKRRKIREALKSVYTNKAAPDMKSQAA---SREPNMGRLEIINSDDLQFDESSTPLGTGAFGAVYRGKWRVPKRILAEYNWPRSTNLDVAVKVIRSPAEPVRGTVSGKAATMEPSDTSPEAKVMERIAEKNNLNEMLSEAKVMASVSHLNCLPLIGVCLTKNMQCMVSAFVELGSIDRYLRENKDSLNSYTLLSWAEQIADGMAYLEARGIIHRDLAARNVLLQSPEHVQITDFGLAKMLDSLDENSVVVRSGRVPIRWLAIETLQFGIYSHKTDVWSYGVTLWEIFTFGKQPYENIETVDIKDHVMKGGRLTQPDICTLDAYMVMVKCWMEDYDSRPTFLELMRLFHDFCQTPGRYLYI 1287          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629])

HSP 1 Score: 275.018 bits (702), Expect = 3.313e-75
Identity = 167/506 (33.00%), Postives = 252/506 (49.80%), Query Frame = 1
Query: 2149 CHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCLLAN--DSTACTRCLNHKLFVDDDKNKFSCVTRCPH------DRNFTEYQDGDFICL-------------KFEETINSKQRKTIFIILSGCFG----FLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            C  MC           MC  CK Y     CV  C+ ++    + E+   C +C  ECR  NG L  +      C  C + +       +   CV RCP       D    +Y D   +C              + ++    K    + +I +G  G    F++  +G  VL  R    + R L  +              ++E  +  P       PN   ++++  ++       K LGSGAFG VY+G W VP  ++  + + V IKV+  + S  +  E L+EA +MASV H H   L+G+CL+     LVS    +G L  Y+++N   I S  +L W  QIA GM YL  R ++HRDLAARNVLV    +++ITDFGLA+L+   +       GKVPI+W+A+E++L  TY+  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP I T++VYM+M+KCW+ D   RP F EL++ F +  + P R+L +
Sbjct:  448 CDEMCTPEGCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECEVNMTCLECDPECRPLNGSLTCSKPGPDGCVECAHFR-------DGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQGCTGPELKDCREYKPFSGMSVIAAGVVGGILAFVILSLGVAVLVRRRHIKRKRTLRRL--------------LQERELVEPLTPSGEAPNQSLLRILKETEF---KKIKVLGSGAFGTVYKGLW-VPEGED--VKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLT-STVQLVSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADEKEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVI 925          

HSP 2 Score: 112.464 bits (280), Expect = 2.327e-24
Identity = 147/577 (25.48%), Postives = 222/577 (38.47%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAP----RPN-HIFGMDSKDKLRYTVGGLCTSQCPAS-LLDQNKICVYECD---FDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTV-----PMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVY-GKISIGGTNGTCYLDRIPWEEI------------SPDNRVKFSCNKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ-----NCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNV-----NAPITCQLCHSSCFVDKTLVGTNHACTGP 1974
            N   RIPL NL++IRG TL +   AL ++ N++ N   L E+ L +L   M                                               CH++C   +         C+ P +  CQ  TK  C +    + CK  K  +  C+  CA GC G    DC  C     D+ C  +C P     PN H    +   K  Y  G  C   CP + ++  +  CV  C    ++  +    +C +C  G C    +G  + N+  +           S+N   +    NCT I GD+ I   + N +  T      P   +  + V+EI G   +  +   + +L+   NLE IR   K H    ++ I    I  LGL+ L+++  G +SI      CY     W+ +            + D     + N+TCD +CT + CWGPG  MC+SC +Y    SCV  C+   G    + E   + C  C P CR       C+ P P  C  +C +  +   CV  C        + +     ++   CQLCH +C            CTGP
Sbjct:   83 NKAPRIPLDNLRIIRGHTLYDG-LALAVLSNYN-NSKGLRELPLISLTGKM-----------------------------------------------CHSDCYNGS---------CWAPGRANCQTFTKLTCAEQCSGR-CKGPKPSDC-CNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGK--YNFGATCVKNCPHNYVVTDHGACVRSCSPGTYEVDEDGVRKCKKC-EGLCPKVCSGLGVGNLVGV----------MSINSSNIDSFENCTTINGDVLILKTTLNGDTFTKTPKMDPAKLNVFRTVKEITGSLLVQYWPKNMPSLSPFENLEVIRGRTK-HQGTVSLGIGKLPITHLGLRALREISDGDVSISANAKLCYNSPEHWKRLFRSEDQVARPMQNADPATCAALNQTCDEMCTPEGCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEH-RECEV-NMTCLECDPECRPLNGSLTCSKPGPDGC-VECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNC---------TQGCTGP 573          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629])

HSP 1 Score: 275.404 bits (703), Expect = 4.711e-75
Identity = 167/506 (33.00%), Postives = 252/506 (49.80%), Query Frame = 1
Query: 2149 CHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCLLAN--DSTACTRCLNHKLFVDDDKNKFSCVTRCPH------DRNFTEYQDGDFICL-------------KFEETINSKQRKTIFIILSGCFG----FLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            C  MC           MC  CK Y     CV  C+ ++    + E+   C +C  ECR  NG L  +      C  C + +       +   CV RCP       D    +Y D   +C              + ++    K    + +I +G  G    F++  +G  VL  R    + R L  +              ++E  +  P       PN   ++++  ++       K LGSGAFG VY+G W VP  ++  + + V IKV+  + S  +  E L+EA +MASV H H   L+G+CL+     LVS    +G L  Y+++N   I S  +L W  QIA GM YL  R ++HRDLAARNVLV    +++ITDFGLA+L+   +       GKVPI+W+A+E++L  TY+  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP I T++VYM+M+KCW+ D   RP F EL++ F +  + P R+L +
Sbjct:  508 CDEMCTPEGCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECEVNMTCLECDPECRPLNGSLTCSKPGPDGCVECAHFR-------DGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQGCTGPELKDCREYKPFSGMSVIAAGVVGGILAFVILSLGVAVLVRRRHIKRKRTLRRL--------------LQERELVEPLTPSGEAPNQSLLRILKETEF---KKIKVLGSGAFGTVYKGLW-VPEGED--VKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLT-STVQLVSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADEKEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVI 985          

HSP 2 Score: 140.584 bits (353), Expect = 4.915e-33
Identity = 159/581 (27.37%), Postives = 245/581 (42.17%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAK----CHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAP----RPN-HIFGMDSKDKLRYTVGGLCTSQCPAS-LLDQNKICVYECD---FDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTV-----PMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVY-GKISIGGTNGTCYLDRIPWEEI------------SPDNRVKFSCNKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ-----NCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNV-----NAPITCQLCHSSCFVDKTLVGTNHACTGP 1974
            N   RIPL NL++IRG TL +   AL ++ N++ N   L E+ L +L  I+   V  + NP L  +E  + W+ I+    +     S+FV+  + T+K    CH++C          +  C+ P +  CQ  TK  C +    + CK  K  +  C+  CA GC G    DC  C     D+ C  +C P     PN H    +   K  Y  G  C   CP + ++  +  CV  C    ++  +    +C +C  G C    +G  + N+  +           S+N   +    NCT I GD+ I   + N +  T      P   +  + V+EI G   +  +   + +L+   NLE IR   K H    ++ I    I  LGL+ L+++  G +SI      CY     W+ +            + D     + N+TCD +CT + CWGPG  MC+SC +Y    SCV  C+   G    + E   + C  C P CR       C+ P P  C  +C +  +   CV  C        + +     ++   CQLCH +C            CTGP
Sbjct:   98 NKAPRIPLDNLRIIRGHTLYDG-LALAVLSNYN-NSKGLRELPLISLTEILKGGVKFAHNPYLCNVE-TIQWADIMSSKDS-----SQFVKFESTTSKDCKMCHSDC---------YNGSCWAPGRANCQTFTKLTCAEQCSGR-CKGPKPSDC-CNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGK--YNFGATCVKNCPHNYVVTDHGACVRSCSPGTYEVDEDGVRKCKKC-EGLCPKVCSGLGVGNLVGV----------MSINSSNIDSFENCTTINGDVLILKTTLNGDTFTKTPKMDPAKLNVFRTVKEITGSLLVQYWPKNMPSLSPFENLEVIRGRTK-HQGTVSLGIGKLPITHLGLRALREISDGDVSISANAKLCYNSPEHWKRLFRSEDQVARPMQNADPATCAALNQTCDEMCTPEGCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEH-RECEV-NMTCLECDPECRPLNGSLTCSKPGPDGC-VECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNC---------TQGCTGP 633          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Cavefish
Match: erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:NCBI gene;Acc:103042851])

HSP 1 Score: 272.322 bits (695), Expect = 4.366e-74
Identity = 202/683 (29.58%), Postives = 321/683 (47.00%), Query Frame = 1
Query: 1660 YKAGNSCVKQCSDSPGYFASQT-----------EFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGC----SKCEKLIKTNNNQYLCHKGSCPKGFYQSVI--NQNISHLHKNIVHQSSCEP----CHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCL--LANDSTACTRCLNHKLFVDDDKNKFSCVTRCPH----DR-NFTEYQDGD-----------FICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            +  G +CVKQC  +  Y A +            E  TI+         + C G  PK C G    +++    V + +I  F     +          S  F+ ++  G   +    S  + + G     S    L+  +NN  LC+  S P   + S++  +Q  + +  N     +CE     C  +C+  +        C  CK Y    +CV++C+    +  +   G  C  CH ECR  NG    +   +  C  CLN++   D D     CV +CP     DR N  +Y +               CL  E     +Q+      ++   G +V  +    L   +   Q R+           KE   + ++E  +  P       PN  +M+++  ++L      + LGSGAFG VY+G W     D + + + V IKV+  N+S  +  E L+EA +MA V+  +   L+G+CL+     LV+    +G L  Y+++N   I S  +L W  QIA GM+YL    ++HRDLAARNVLV   ++++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   +I   L+ G RL QP I T++VYM+M+KCW+ DP  RP F ELV+ F    + P R++ +
Sbjct:  271 FSFGATCVKQCPHN--YLAMEVACTLVCPKANQEVITIEPDAQETQKCEKCDGECPKVCYGLGMGSLQRVMAVNSSNIGLFKGCKKIYG--------SLAFLTQSFKGGVFSLGVQSLQIESLGLRSLRSVSGGLVLVHNNPQLCYTSSLP---WSSLLYPSQEPNLISNNNREPQACEAEGHQCDPLCKDGACWGPGPSQCVSCKSYQRGTECVEQCNIWSGLQREFIDGSSCIPCHAECRPINGSASCIGPGADDCKECLNYQ---DGDM----CVDQCPKSIKGDRHNVWKYSNESGYCLPCPHNCSLNCLTDERGCPIQQKSGPGTTIAAAMGGVVLFLILLALLIFYLRRQKRM---------KKKETMRRILQEHELVEPLTPSGAMPNQAQMRILKETEL---KKLRVLGSGAFGTVYKGIWA---PDGEKVKIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCRLLGICLT-STVQLVTQLMPYGCLLDYVRENKDHIGSQYLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGMKPYDLIPARDIPELLEGGERLPQPLICTIDVYMIMVKCWMIDPESRPKFKELVTNFSCMARDPPRYVVI 917          

HSP 2 Score: 110.153 bits (274), Expect = 1.017e-23
Identity = 130/529 (24.57%), Postives = 197/529 (37.24%), Query Frame = 1
Query:  370 VKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKI---------GNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVT--FQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEE----------ISPDNRVKFSCNK---TCDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEF-KTIKCQTCHPLCR-----QNCTGPTPKNCGGQCRYAIEENTCVKNC 1854
            V  IPL NL++IRG  L N   AL  + N       +E++   +L  I+   V I  NP L Y  +N++W  I+ D        S+ +R  +    C T C       G     C+G +  +CQ  T+         CK     +  C  +CA GC G    DC  C        C  +C P   +    +        +++ G  C  QCP + L     C   C   A+Q++           +C +C +G C       K+C               Y L   +L ++               + N + + +       K  ++I G  + +T  F+  + +L   S      L ++S  + S  ++ G               G + +      CY   +PW            IS +NR   +C      CDPLC  G CWGPG   C SC  Y+ G  CV+QC+   G    Q EF     C  CH  CR      +C GP   +C  +C    + + CV  C
Sbjct:   92 VPVIPLKNLRIIRGSQLYNSSFALAALENPQ-----VEQLQFSSLTEILLGEVYIWGNPQLCY-PRNINWKDIVGD--------SKSIRVQSAVPYC-TSCPATCGSRG-----CWGRAAEDCQTLTRIPCASGCTRCKGPDASDC-CHVQCAAGCSGPKDSDCLACRHFNDSGTCRDNCPPPIIYDPLTYQSKPNPNKKFSFGATCVKQCPHNYLAMEVACTLVCP-KANQEVITIEPDAQETQKCEKC-DGECP------KVC---------------YGLGMGSLQRVM--------------AVNSSNIGL------FKGCKKIYGSLAFLTQSFKGGVFSLGVQS------LQIESLGLRSLRSVSG---------------GLVLVHNNPQLCYTSSLPWSSLLYPSQEPNLISNNNREPQACEAEGHQCDPLCKDGACWGPGPSQCVSCKSYQRGTECVEQCNIWSGL---QREFIDGSSCIPCHAECRPINGSASCIGPGADDC-KECLNYQDGDMCVDQC 531          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Cavefish
Match: erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:NCBI gene;Acc:103042851])

HSP 1 Score: 270.781 bits (691), Expect = 1.996e-73
Identity = 176/549 (32.06%), Postives = 277/549 (50.46%), Query Frame = 1
Query: 2017 LIKTNNNQYLCHKGSCPKGFYQSVI--NQNISHLHKNIVHQSSCEP----CHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCL--LANDSTACTRCLNHKLFVDDDKNKFSCVTRCPH----DR-NFTEYQDGD-----------FICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            L+  +NN  LC+  S P   + S++  +Q  + +  N     +CE     C  +C+  +        C  CK Y    +CV++C+    +  +   G  C  CH ECR  NG    +   +  C  CLN++   D D     CV +CP     DR N  +Y +               CL  E     +Q+      ++   G +V  +    L   +   Q R+           KE   + ++E  +  P       PN  +M+++  ++L      + LGSGAFG VY+G W     D + + + V IKV+  N+S  +  E L+EA +MA V+  +   L+G+CL+     LV+    +G L  Y+++N   I S  +L W  QIA GM+YL    ++HRDLAARNVLV   ++++ITDFGLARL+D  +       GKVPI+W+A+E++L   ++  +DVW+YGVT+WE+ T+  +PY+ +   +I   L+ G RL QP I T++VYM+M+KCW+ DP  RP F ELV+ F    + P R++ +
Sbjct:  450 LVLVHNNPQLCYTSSLP---WSSLLYPSQEPNLISNNNREPQACEAEGHQCDPLCKDGACWGPGPSQCVSCKSYQRGTECVEQCNIWSGLQREFIDGSSCIPCHAECRPINGSASCIGPGADDCKECLNYQ---DGDM----CVDQCPKSIKGDRHNVWKYSNESGYCLPCPHNCSLNCLTDERGCPIQQKSGPGTTIAAAMGGVVLFLILLALLIFYLRRQKRM---------KKKETMRRILQEHELVEPLTPSGAMPNQAQMRILKETEL---KKLRVLGSGAFGTVYKGIWA---PDGEKVKIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCRLLGICLT-STVQLVTQLMPYGCLLDYVRENKDHIGSQYLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGMKPYDLIPARDIPELLEGGERLPQPLICTIDVYMIMVKCWMIDPESRPKFKELVTNFSCMARDPPRYVVI 972          

HSP 2 Score: 127.872 bits (320), Expect = 4.150e-29
Identity = 141/533 (26.45%), Postives = 208/533 (39.02%), Query Frame = 1
Query:  370 VKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKI---------GNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVT-----VPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGT-CYLDRIPWEE----------ISPDNRVKFSCNK---TCDPLCT-GQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEF-KTIKCQTCHPLCR-----QNCTGPTPKNCGGQCRYAIEENTCVKNC 1854
            V  IPL NL++IRG  L N   AL  + N       +E++   +L  I+   V I  NP L Y  +N++W  I+ D        S+ +R  +    C T C       G     C+G +  +CQ  T+         CK     +  C  +CA GC G    DC  C        C  +C P   +    +        +++ G  C  QCP + L     C   C   A+Q++           +C +C +G C     G  + ++           R  ++N   +     C  I G L     SF  +  +      P      + + EI G   +  +    ++L    NL+ IR  +    V S + +    IE LGL+ L+ V G + +   N   CY   +PW            IS +NR   +C      CDPLC  G CWGPG   C SC  Y+ G  CV+QC+   G    Q EF     C  CH  CR      +C GP   +C  +C    + + CV  C
Sbjct:   92 VPVIPLKNLRIIRGSQLYNSSFALAALENPQ-----VEQLQFSSLTEILLGEVYIWGNPQLCY-PRNINWKDIVGD--------SKSIRVQSAVPYC-TSCPATCGSRG-----CWGRAAEDCQTLTRIPCASGCTRCKGPDASDC-CHVQCAAGCSGPKDSDCLACRHFNDSGTCRDNCPPPIIYDPLTYQSKPNPNKKFSFGATCVKQCPHNYLAMEVACTLVCP-KANQEVITIEPDAQETQKCEKC-DGECPKVCYGLGMGSL----------QRVMAVNSSNIGLFKGCKKIYGSLAFLTQSFKGDPFSNLSSLQPDDLEVFRTLEEITGYLYIDAWPQNWTDLGVFENLKVIRGRMLYKGVFS-LGVQSLQIESLGLRSLRSVSGGLVLVHNNPQLCYTSSLPWSSLLYPSQEPNLISNNNREPQACEAEGHQCDPLCKDGACWGPGPSQCVSCKSYQRGTECVEQCNIWSGL---QREFIDGSSCIPCHAECRPINGSASCIGPGADDC-KECLNYQDGDMCVDQC 586          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Cavefish
Match: ENSAMXT00000016431.2 (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103032492])

HSP 1 Score: 263.077 bits (671), Expect = 5.632e-72
Identity = 165/531 (31.07%), Postives = 266/531 (50.09%), Query Frame = 1
Query: 2020 IKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEK-------RMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPH------DRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYF---RWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHN-SSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            +   NN  LC+  +    +++ +   +   +        SC       R C G   E+        MC  C+      +CV  C+ ++ +  +    + C +C +ECR   L    +  C  C + K    D  N   CV++C +      +R    + D +  C       N      + ++ SG  G L+F++   +  F   R +  + R             EP   +         PN   ++++  ++       K LGSGAFG VY+G W +P  ++  + + V IKV+   +S  +  E L+EA +MASV H H   L+G+CL+     L++     G L  Y+++N   I S ++L W  QIA GM YL +  ++HRDLAARNVLV   ++++ITDFGLA+L++  +       GKVPI+W+A+E++L  TY+  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G RL QP I T++VYM+M+KCW+ DP  RP F EL S F +  + P R+L +
Sbjct:  422 VVIKNNPRLCYTNA---NYWRKLFRSDTQTIKTRDNLGDSCNSAEVQNRMCDGMCTEEGCWGPGPSMCFSCRHVSRQGQCVDSCNILEGMPREYISNNMCLECDQECRT--LNGTPTDQCVECAHFK----DGSN---CVSQCANGVPGMNNRLIWTFVDKNRQCQPCHP--NCTHGSQVSMVASGVVGGLLFVVIVFLCIFILMRRKRIRRRRTLRRLLQERELVEPLTPS------GAAPNQALLRILKETEF---KKVKVLGSGAFGTVYKGLW-IPEGED--VKIPVAIKVLREVTSPKANKEILDEAYVMASVDHPHICRLLGICLT-STVQLITQLMPFGCLLDYIRENQDNIGSQNLLNWCVQIAKGMNYLEEHRLVHRDLAARNVLVKTPNHVKITDFGLAKLLNANEKEYHSDGGKVPIKWMALESILHWTYTHQSDVWSYGVTVWELMTFGAKPYDGIPAQEISGLLEKGERLPQPSICTIDVYMIMVKCWMIDPDSRPRFRELSSEFTKMARDPTRYLVI 925          

HSP 2 Score: 102.064 bits (253), Expect = 3.399e-21
Identity = 119/448 (26.56%), Postives = 178/448 (39.73%), Query Frame = 1
Query:  712 CFGPSKNECQKQTKCVKNKDLKW-CKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPR-----PN-HIFGMDSKDKLRYTVGGLCTSQCPAS-LLDQNKICVYECDFDAHQKIGN---RCIECPNGNC--------NSSTAGYKLCNIATIDKFY--PKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVY-GKISIGGTNGTCYLDRIPW--------EEISPDNRVKFSCN------KTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANN------VNAPITCQLCHSSC 1926
            C+ P    CQK T+ +  +     CK     +  C+  CA GC G  + DC  C +   D  C  +C PR     PN H   ++   K  ++ G  C   CP + ++  +  CV  C    H+   N   +C  C NG C        N   AG    N + ID F    K N   S+   TL                   + K     P    + K V+EI G   +  +   +++L+   NLE IR   + H   S   ++  +IE+LGL+ LK++  G + I      CY +   W        + I   + +  SCN      + CD +CT + CWGPG  MC+SC +      CV  C+   G    +       C  C   CR      TP +   +C +  + + CV  C+ +  P  NN      V+    CQ CH +C
Sbjct:  159 CWAPGPENCQKLTRLICAEQCSHRCKGPAIADC-CNEHCAAGCTGPLATDCLACREFKDDGMCKDAC-PRLMLYDPNLHQLVVNPNGK--FSFGATCVKNCPHNYVVTDHGACVRTCGDKTHEVEENGIRKCKNC-NGPCPKVCNGLGNGELAGIMTVNASNIDTFQNCTKINGDISIFATTL---------------RGDPYTKTPKLDPAKLDYFKTVKEITGFLLIQAWPENLTSLSPFENLEVIRGRTQQHGRVSFAALNIAHIEYLGLRSLKEISDGDVVIKNNPRLCYTNANYWRKLFRSDTQTIKTRDNLGDSCNSAEVQNRMCDGMCTEEGCWGPGPSMCFSCRHVSRQGQCVDSCNILEGM--PREYISNNMCLECDQECRT--LNGTPTDQCVECAHFKDGSNCVSQCA-NGVPGMNNRLIWTFVDKNRQCQPCHPNC 581          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003172.1 (pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 gene:ENSPMAG00000002842.1 transcript:ENSPMAT00000003172.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 253.062 bits (645), Expect = 5.250e-70
Identity = 173/556 (31.12%), Postives = 272/556 (48.92%), Query Frame = 1
Query: 2020 IKTNNNQYLCHKGSC--PKGFYQSVINQNISHLHKNIVHQSSCEPCHSMC------RTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDST--------ACTRCLNHKLFVDDDKNKFSCVTRCP------HDRNFTEYQD-------------------GDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            +   NN+ LC+  +   P  F   V  Q  S++H N   ++ C    ++C        C G   ++  C  C+ +     CV+ C   +    +      C  C  EC    L  NDS         +C RC ++K       +   CV+ CP      +D   ++Y D                   G   C        +       + + G F  ++ ++   V+  R R N  R  A  + +     EP   +         PN  +++++  ++L      K LGSGAFG V++G W    +D   + + V IKV+  + S  +  E L+EA IMASVSH H + L+G+CL+     LV+     G L +Y +++ + I S  +L WA QIA GM YL ++ ++HRDLAARNVLV    +++ITDFGLARL+D  +       GK+PI+WLA+E++   T++  +DVW+YGVT+WE+ T+  +PYE +   +I   L++G RL QP I T++VYM+M+KCW+ D   RP F EL   F +  + P+R+L +
Sbjct:  320 VYLKNNERLCYYNTIKWPAVF---VSEQQTSYVHDN-KPEADCNADGAVCDLLCSEHGCWGPGPDQ--CISCRFFRRARSCVESCYITEGPYREHMQDAVCAPCDPEC----LPVNDSVTCFGPGSNSCVRCAHYK-------DGPHCVSACPVGAQGENDEIISKYPDKNNTCQPCHPNCSHGCKGGGLLDCHLIGPLFRTGSPVLAVMAVGGLFACVMLLL-LAVVCVR-RRNIARKRAMRRYIEKELVEPLTPSGAA------PNQAQLRILKETEL---RKGKMLGSGAFGTVHKGIWTPEGED---VKIPVAIKVLREATSPKANKEILDEAYIMASVSHPHLVRLLGICLTPSVQ-LVTQLMPLGCLLEYTREHKEHIGSQLLLNWAVQIAKGMMYLEEQRLVHRDLAARNVLVRTPQHVKITDFGLARLLDINEIEYHADGGKMPIKWLALESIQYRTFTHQSDVWSYGVTIWELMTFGGKPYEGIPARDIPELLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFKELAVEFSKMARDPQRYLVI 843          

HSP 2 Score: 112.079 bits (279), Expect = 4.908e-25
Identity = 134/564 (23.76%), Postives = 204/564 (36.17%), Query Frame = 1
Query:  502 LRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNH---IFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQ--KIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNG-VTVPML----YHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVK-------SHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI---------SPDNRVKFSCNK---TCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLC-----RQNCTGPTPKNCGGQCRYAIEENTCVKNCS----------IDFFPVANNVNAPITCQLCHSSC--------FVDKTLVGTNHACTGPS-NILGTGGCSKCEKLI 2022
            L  I+   V I +N  L Y    +DW  I+ + +   + +      S     CH  C           + C+G     CQK   C K    + C     G  P   C  +CA GCDG     C  C        CVS C P   +    F       ++Y+ G +C  +CP + +     CV  C    H+  K G +  E     C  +  G    N++          R  +++   +    NCT I G++         +  + +P L     +  ++++EI G   +  +   +++     NL  IR  V        S  VA   NI    +  L       VY K         CY + I W  +           DN+ +  CN     CD LC+   CWGPG + C SC +++   SCV+ C  + G +  +   +   C  C P C        C GP   +C  +C +  +   CV  C           I  +P  NN     TCQ CH +C         +D  L+G       P   ++  GG   C  L+
Sbjct:    1 LSEILHGGVYIKENKHLCY-HNTVDWWDIVKEGSIVNIDMDN----STTCTSCHKGCH----------KHCWGNGMKYCQK---CTKLTCARQCDGRCHGPTPSECCHSQCAAGCDGPRDTHCFACKNFNDSGSCVSHCPPPTIYNPVTFAQGENPDVKYSYGAICVKECPHNFVVDYNSCVRACPAGKHEVEKFGKKKCETCTDVCPKACDGIGTGNLS----------RSQTVDATNIDTFENCTKINGNIAFLTTGIKGDDYMKIPPLDPDKLNVFRSIKEITGHLMIQAWPENMTDFAVFENLTTIRGRVLQSVGRTFSLLVARIPNITALGLASLQEVSAGNVYLK----NNERLCYYNTIKWPAVFVSEQQTSYVHDNKPEADCNADGAVCDLLCSEHGCWGPGPDQCISCRFFRRARSCVESCYITEGPY--REHMQDAVCAPCDPECLPVNDSVTCFGPGSNSC-VRCAHYKDGPHCVSACPVGAQGENDEIISKYPDKNN-----TCQPCHPNCSHGCKGGGLLDCHLIGPLFRTGSPVLAVMAVGGLFACVMLL 524          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Sea Lamprey
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236])

HSP 1 Score: 195.667 bits (496), Expect = 4.755e-51
Identity = 134/495 (27.07%), Postives = 231/495 (46.67%), Query Frame = 1
Query: 2149 CHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCLLANDSTA--CTRCLNHKLFVDDDKNKFSCVTRCPH------DRNFTEYQDGDFICLK-----FEETINSKQRKTIF--------IILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            C ++C            C  CK +     CV+ C  +     +   G  C  CH EC   NG L  +      CTRC N+       +    CV  CP            +Y D D +C        +  I  + +   +        +I +G    L  +    +  F ++ +Q  +       Y   + P +         + PN  +++++  ++L      K LGSGAFG VY+G W VP  + + + + V +KV+ +S S  +  + L+EA +MASV H H + L+G+C+S     LV+    HG L +Y++++  ++ S  +L W  QIA   + +    ++  DL    + +     I +     A L    DD+       +PI+W+A+E++    ++  +DVW+YGVT+WE+ T+  +PY+ ++  +I   L++G RL QP + T++VYM+M+KCW+ D   RP F EL + F +  + P R+L +
Sbjct:  476 CDALCSAEGCWGPGPMQCLSCKFHKRGKTCVESCSVLDGDEREFVSGALCIACHAECMLINGSLTCHGPGPDNCTRCRNY-------REGPHCVGFCPEGVPGESGELIYKYPDEDGVCHPCHYNCTQGEIGERHKGAPYWANVNKVPVIAAGVVSGLFAVFLLLLALFIYKRHQNALRKRTLRKYVENERPQLVQPLTPSGAQ-PNQAQLRILKETEL---KKGKVLGSGAFGTVYKGIW-VP--EGESVKIAVAVKVLRDSASSKANKDILDEAYLMASVDHPHLVRLLGICMSSTTQ-LVTQLMPHGCLLEYVREHRGRVGSQLILNWCVQIAKNASEIQALQMVCDDLVRLVMSLRTPPRITLAS---ANLFQSIDDAKHWHDRDMPIKWMALESIQYRKFTHQSDVWSYGVTVWELMTFGGKPYDGISARDIPGLLEKGERLPQPPVCTIDVYMIMVKCWMIDAESRPRFSELATDFSKMARDPSRYLVI 952          

HSP 2 Score: 88.5817 bits (218), Expect = 8.400e-18
Identity = 142/609 (23.32%), Postives = 235/609 (38.59%), Query Frame = 1
Query:  154 CVVSEAHGSFKTPAE-AYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHS----ENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVS----EFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDS---DCVSSCAPRPNHIFGMDSKDKLRYTVGGLCTSQCPAS--LLDQNKICVYECDFDAHQKIGN----RCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFN-----KNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI---SPDNRVKFSCNK------TCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKT-IKCQTCHPLC-----RQNCTGPTPKNCGGQCRYAIEENTCVKNC 1854
            CV +E   S    AE  Y  L+    +   C  + GNL   +++  +NGSD         +     +++  N+V  +PL NL+V+RG  L ++  AL ++ N++    E    L+E+ L  L  I+   V + + PGL        W  I +  + +   +     +F   S     CH  C+           FC+G     CQ  T  +  K    C     G  P   C   CA GC G    DC   +     +   D V         I+  D+  +    +     +  PA   ++D N  CV  C  +  +         C  CP+  C       K+C+     K         +++ + +   +NCT I G+L      F+     +NG+ V       ++++++ G   L  +  +   L FL +L+  + S K       + +H   +  L          +++       C++  +    +     + R   +C++       CD LC+ + CWGPG   C SC ++K G +CV+ CS   G    + EF +   C  CH  C        C GP P NC  +CR   E   CV  C
Sbjct:    1 CVGTENKMSLLGSAEKQYNTLR---SMYTNCEVVMGNL---EITYIRNGSDLSFLRTIREVSGYVLIAL--NEVDHVPLENLRVVRGTRLYDQRYALTVLLNYNDSVPEERLGLKELRLTRLTEILRGGVYVRKEPGLP------SWDDIRNRNSKENFFLPVVACDFSSVSLSGQPCHPSCK----------NFCWGSGPQYCQTFTSTICAKQ---CDGRCYGLDPNQCCHKHCASGCTGPRETDCFPASSWRSRASIQDNVLCGLFFSVTIYQFDNPPRGNLALRQALVADFPAGNFVVDYNS-CVRSCPVNKTEVEDGSGVKHCKPCPDNLCP------KVCDGIGSGKL----KEAQTVDAKNIHFFSNCTTISGNLIFLRNGFDGNCHFQNGIHVKP--RCCQSLQQLTGSLLLNHYPVRWQVLPFLLHLDLSKPSRKQFWRLHVLLVHKSLLFMLMRYCTYVKSFQVTATVHPIFCFVSTLFGSSLYSTKSNGRHCCACDRPGKEGYVCDALCSAEGCWGPGPMQCLSCKFHKRGKTCVESCSVLDG---DEREFVSGALCIACHAECMLINGSLTCHGPGPDNC-TRCRNYREGPHCVGFC 565          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005822.1 (pep scaffold:Pmarinus_7.0:GL476959:64997:68848:-1 gene:ENSPMAG00000005273.1 transcript:ENSPMAT00000005822.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 169.088 bits (427), Expect = 5.535e-48
Identity = 72/156 (46.15%), Postives = 108/156 (69.23%), Query Frame = 1
Query: 3088 GMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFL 3555
            GM YL  R ++HRDLAARNVLV   ++++ITDFGLA+L+D  +     + GK+PI+WLA+E++    ++  +DVW+YGVTLWE+ T+  +PY+ +   +I   L++G RL QP I T++VYM+M+KCW+ D   RP F EL + F +  + P R+L
Sbjct:    1 GMNYLEDRRLVHRDLAARNVLVKAPNHVKITDFGLAKLLDLNETEYHSEGGKLPIKWLALESIQQRIFTHQSDVWSYGVTLWELMTFGGKPYDGVPARDIPELLEKGERLTQPPICTIDVYMIMVKCWMIDAESRPKFRELAAEFSKMARDPTRYL 156          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Sea Lamprey
Match: EPHB2 (EPH receptor B2 [Source:HGNC Symbol;Acc:HGNC:3393])

HSP 1 Score: 182.185 bits (461), Expect = 6.986e-47
Identity = 99/318 (31.13%), Postives = 173/318 (54.40%), Query Frame = 1
Query: 2620 EIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLV--DETDDSIVIK-SGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            +++  ++    P MK   + +    PN    +     D+   T  + +GSG FG+V RG  ++P +   Y    V IK + ++ ++    +FL EA IM    H + + L GV        +V+ + ++GSLD +L+QN  + +   ++   + IA GM YL+    +HRDLAARN+LVN +   +++DFGL+R +  D TD +      GK+PIRW A E +    ++ A+DVW+YG+ +WE+ +Y +RPY ++   ++ + ++Q  RL  P      ++ +M+ CW    + RP F ++VST ++ I++P     M
Sbjct:  539 KLQQYHTGHSTPGMKMYIDPFTYEDPNEAIREFAREIDISCVTIEQVIGSGEFGEVCRGRLRMPGKREMY----VAIKTLKSAYTEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLENDPTDPTYTSGMGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNEDVINAVEQDYRLPAPMDCPAALHQLMLDCWQKSRNDRPKFGQIVSTLDKMIRNPASLKAM 852          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7])

HSP 1 Score: 169.088 bits (427), Expect = 8.681e-46
Identity = 96/275 (34.91%), Postives = 148/275 (53.82%), Query Frame = 1
Query: 2755 KPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSH-SMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYV 3576
            + LG+G FG+VY G W      NK     V +K +   +    +EFL EA IM   +H + + L  VC + E   +++    +GSL +YLQ +   +     ++  A Q+A GMAYL  +  IHRDLAARN+LV D+   ++ DFGLAR++ + D+ I  + GK P++W A E    + ++  +DVW++G+ L+EI TY K PY  +   E+   L+ G R+  P     + Y +M  CW  +   RPSF++L    E  I         PHE++
Sbjct:  127 RQLGAGQFGEVYEGLW------NK--TTRVAVKTLKPGAM-VPEEFLAEAHIMKRFTHCNLIQLYAVCTTEEPIYIITELMVNGSLLQYLQNDEGGVLKMCHLINMAVQVASGMAYLEAQNYIHRDLAARNILVGDNLTCKVADFGLARVIKD-DEYIAREGGKFPVKWTAPEAANYSRFTIKSDVWSFGILLYEIVTYGKVPYAGMTNAEVLEELEHGYRMPCPTNCPRDFYSIMYNCWHKEEACRPSFLQLDHQLEDLITDYSE----PHEFL 387          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 91.2781 bits (225), Expect = 7.969e-19
Identity = 59/251 (23.51%), Postives = 126/251 (50.20%), Query Frame = 1
Query: 2761 LGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELV 3513
            +G G++G VY+         NK+ +  V IK +   +    ++ + E  ++ +++H + +   G      +  ++  Y  +GSL + + ++S  +S +    +  Q   G+ YL+  G+IHRD+ A N+L++ D+ +++ DFG++ +V+    S +  +G   + W+A E L +   S  +D+W+ G T+ E+ T    PY  L    I  +  + +    P   +  +   + KC++ + + RP+  +L+
Sbjct:   31 IGRGSYGVVYKAI-------NKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNS---SALTLAGT--LNWMAPEILGNRGASTLSDIWSLGATVVEMLT-KNPPYHNLTDANIY-YAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLL 267          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529])

HSP 1 Score: 86.2705 bits (212), Expect = 3.119e-17
Identity = 57/209 (27.27%), Postives = 103/209 (49.28%), Query Frame = 1
Query: 2893 LEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSAT--YSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELV 3513
            + EA +   + H H   L  +C       ++  Y   G L  Y+ Q+   I  H   K+A+ IA  + YL+   I+HRDL   N++++D   I+I DFGL+ + D +   +    G +   + A   LL A     P  DVW++GV L+ +    K P+++  +  +   ++QG ++  P+  ++EV  ++ K  + DP  R +  ++V
Sbjct:  192 IREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGS-IREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYD-SRKQLHTFCGSL---YFAAPELLKANPYTGPEVDVWSFGVVLF-VLVCGKVPFDDENSSVLHEKIKQG-KVEYPQHLSIEVISLLSKMLVVDPKRRATLKQVV 393          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Yeast
Match: SNF1 (AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase [Source:SGD;Acc:S000002885])

HSP 1 Score: 78.1814 bits (191), Expect = 6.218e-15
Identity = 57/197 (28.93%), Postives = 97/197 (49.24%), Query Frame = 1
Query: 2755 KPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD---EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYS-PATDVWAYGVTLW 3333
            K LG G+FGKV   Y     Q       +V +K+I+      +D       E   +  + H H + L  V  S ++  +V  YA +   D  +Q++  K+S     ++ +QI   + Y ++  I+HRDL   N+L+++  N++I DFGL+ ++  TD + +  S   P  + A E +    Y+ P  DVW+ GV L+
Sbjct:   59 KTLGEGSFGKVKLAYHTTTGQ-------KVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRD--KMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIM--TDGNFLKTSCGSP-NYAAPEVISGKLYAGPEVDVWSCGVILY 243          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 75.8702 bits (185), Expect = 3.151e-14
Identity = 69/292 (23.63%), Postives = 123/292 (42.12%), Query Frame = 1
Query: 2761 LGSGAFGKVYRGY-------------------WKVPRQDNKYIN-------------LEVVIKVIH-----NSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSG-KVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEI---STLEVYMVMIKCWLDDPHMRPSFMELV 3513
            +GSG+FG VY G                      VP  +NK  N             +E V  V H     N  +   D    E  ++  + H + +   G         +   Y   GS+   L  N        +  + +QI  G+AYL+K+ IIHRD+   N+L++    ++ITDFG+++ +   +     ++  +  + W++ E +     +   D+W+ G  + E+FT  K P+ + +  ++++  + G     PEI   +T E    + K +  D   RPS +EL+
Sbjct:  421 IGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSML-NNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFT-GKHPFPDFS--QMQAIFKIGTN-TTPEIPSWATSEGKNFLRKAFELDYQYRPSALELL 707          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086])

HSP 1 Score: 76.2554 bits (186), Expect = 3.433e-14
Identity = 50/208 (24.04%), Postives = 101/208 (48.56%), Query Frame = 1
Query: 2893 LEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYS-PATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELV 3513
            + EA +   + H H   L  +C       ++  Y   G L  Y+ Q+   +  H   K+A+ IA  + YL+   I+HRDL   N++++    I+I DFGL+ + D       + +    + + A E L +  Y+ P  D+W++G+ L+ +    K P+++  +  +   +++G ++  P   ++EV  ++ +  + DP  R +   +V
Sbjct:  171 VREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGS-LKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQ---LHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLY-VLVCGKVPFDDENSSILHEKIKKG-KVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVV 372          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18])

HSP 1 Score: 176.792 bits (447), Expect = 3.493e-49
Identity = 95/251 (37.85%), Postives = 142/251 (56.57%), Query Frame = 1
Query: 2761 LGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQ-NSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMEL 3510
            LG G +G+VY G WK      KY N  V +K +   +    +EFL+EA +M  + H++ + L+GVC       +++ +  +G+L  YL+    K + + +++  A Q+   M+YL     IHRDLAARN LV D++ +++ DFGL+RLV E D     +  K PI+W A E L   T+S  +DVWA+G+ LWE+ TY   PY  +   ++   L  G R+  PE    EVY +M  CW  DP+ RPSF E+
Sbjct:   20 LGGGQYGEVYEGTWK------KY-NKTVAVKTLREETM-EVEEFLKEASVMKGIKHQNLVQLLGVCTREPPFYIITEFMMNGNLLDYLRSPKGKDLDAVTLMYMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLVSE-DIYTAHQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYRMPCPEGCPPEVYSLMQTCWCWDPNSRPSFKEI 261          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Nematostella
Match: EDO40994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K8])

HSP 1 Score: 176.022 bits (445), Expect = 1.207e-47
Identity = 91/267 (34.08%), Postives = 151/267 (56.55%), Query Frame = 1
Query: 2755 KPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRF 3552
            K +G G FG VY+G  K P ++     + V IK +   S+  +  +FL EA +M      + + L GV        +V+ +  +GSLD +L++   K+S   ++  A+ IA GM YL++   +HRDLAARN+LV +    ++ DFGL+R ++  D +     GK+P+RW A E +    +S ++DVW+YG+ LWE F++A+RPY + +  E+   ++ G RL  P      ++ +M++CW  D   RPSF  +V   +  I+SP++ 
Sbjct:   62 KVIGGGEFGDVYKGTLKRPGENT----IPVAIKTLKQGSTSKNRGDFLSEASVMGQFCDPNVIFLEGVVSKTHPLMIVTEFMSNGSLDNFLKKMDSKLSLIQLMGMARGIASGMKYLSEMNFVHRDLAARNILVTETLVCKVADFGLSRELE--DSAYETSGGKIPVRWTAPEAIKYRKFSTSSDVWSYGILLWETFSFAERPYWDWSNFEVMDRVETGYRLPPPMSCPKVIHQIMLECWDADRTKRPSFALIVKQLDSLIRSPEKL 322          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Nematostella
Match: EDO47094 (Predicted protein; Vascular endothelial growth factor receptor-like protein [Source:UniProtKB/TrEMBL;Acc:A7RN88])

HSP 1 Score: 171.4 bits (433), Expect = 3.594e-47
Identity = 101/283 (35.69%), Postives = 153/283 (54.06%), Query Frame = 1
Query: 2761 LGSGAFGKVYRGY------WKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASV-SHRHCLPLIGVCLSLEKPCL--VSTYAQHGSLDKYLQQ---------------NSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFI 3534
            LGSGAFG+VY G       ++ P   +   N++V IK +   +  S   + L E KI+  V SH++ + L+G C    +  L  +  +  +G L  YL++               +  + +   ++  A Q+A GM +L  R  IHRDLAARNVL+ DD  +++ DFGLAR V + ++ +    G VPI+W+AIE+L    YS  +DVW+YGV LWEIFT    PY +L   ++  +L  G R+ +P     E+Y +M  CW+  P  RP+F ELV   ++ I
Sbjct:   22 LGSGAFGQVYLGETEGGIDYRRPSAISMRGNIKVAIKTLKGGATESEQKDLLSELKILIHVGSHKNIVNLLGACTKGPQRDLWIILEFCANGDLLSYLKKKRDIYDPAWCAPSEDHDVQFTQMELVSAAYQVARGMEFLASRRCIHRDLAARNVLIADDYVLKVADFGLARDVYKNEEYVKHTPGLVPIKWIAIESLTDKIYSQKSDVWSYGVLLWEIFTLGGNPYPDLHPSDVFEYLLDGKRMEKPVDCAQEIYNIMTDCWVLSPEDRPTFTELVKKLDKMI 304          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Nematostella
Match: EDO33736 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD7])

HSP 1 Score: 173.711 bits (439), Expect = 5.045e-47
Identity = 88/269 (32.71%), Postives = 156/269 (57.99%), Query Frame = 1
Query: 2761 LGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIH-NSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDS----IVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRF 3552
            +G G F  VYRG   V   ++K    +V +K++   SS  + ++F  EA IM    H + + L GV        +++ + ++GSLD +L+ N  ++++  ++   + +A GMAYL++   IHRDLAARN+LV+D+   +++DFGL+R +D++ ++       + GK+P+RW A E +    +S A+DVW+YG+ LWEI ++ +RPY      ++   ++ G RL  P      ++ +M+ CW  +   RP F ++V  F++ I+SP + 
Sbjct:   33 IGGGEFADVYRG---VLTNEDK-TQEKVAVKILKPGSSHKNREDFCVEASIMGQFDHPNVIALKGVITRTRPMMIITEFLENGSLDNFLKSNDGRLTTLQLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGILLWEIMSFGERPYWTWDNFQVMDRVEGGYRLPAPMKCPKVIHNLMLDCWDKEKTSRPKFADIVRRFDEVIRSPDKM 297          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Nematostella
Match: EDO37886 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEI8])

HSP 1 Score: 168.318 bits (425), Expect = 3.647e-46
Identity = 98/279 (35.13%), Postives = 151/279 (54.12%), Query Frame = 1
Query: 2761 LGSGAFGKVYR----GYWKVPRQDNKYINLEVVIKVI-HNSSKGSTDEFLEEAKIMASVS-HRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNS-------KKISSHSMLKW--------AKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFI 3534
            LGSGAFG+V +    G   +  +D       V +K++  N+S+    +   E KIM  +  H++ + L+G C   E   L+  YA+HG+L ++L+          KK + +   ++        A QIA GM +L  +  IHRDLAARNVLV++   ++I DFGLAR + +TD  +   +G +P++W+A E L    YS  TDVWA+GV LWEI T    PY  +   ++  ++ +G R+ QP     E+Y +M  CW  +   RP+F ELV   E+ +
Sbjct:   21 LGSGAFGQVIKAEAIGILSLSARDKTSEATTVAVKMLKENASESDYKDLASELKIMIHLGEHKNIINLLGACTRGENLMLILEYAKHGNLLQFLRTRRDIYEPTWKKTTFNPKTEFTLADQVVDAYQIAQGMDFLASKKCIHRDLAARNVLVDEGYALKIGDFGLARDIYKTDLYVKKGAGLLPVKWMAPEALFDREYSSKTDVWAFGVVLWEILTLGGSPYPGVPLEQLLDYINEGKRMAQPRDCPPEIYAIMCDCWSLEQDRRPTFAELVRRIERIL 299          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Medaka
Match: egfra (epidermal growth factor receptor [Source:NCBI gene;Acc:101159776])

HSP 1 Score: 275.404 bits (703), Expect = 4.491e-76
Identity = 161/473 (34.04%), Postives = 252/473 (53.28%), Query Frame = 1
Query: 2197 MCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPH------DRNFTEYQDGDFICLKFEETINSKQRKT-IFIILSGCFGFL--VFIIGFCVL------YFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            MC  C+ Y    +CV  C+ ++    +  +   C +C  EC+  NG    +    C +C N +       +   CV+RCP       D    +Y D   +C    +  N  Q  T + +I +G  G L  V + G  V       Y + +    R+L E         EP   +       + PN   ++++  S+       K LGSGAFG VY+G W VP  ++  + + V IKV+  + S  +  E L+EA +MASV + H   L+G+CL+     L++    +G L  Y+++    I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++++ITDFGLA+L++  +       GKVPI+W+A+E++L+ TY+  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G+RL QP I T++VYM+M+KCW+ D   RP F EL+  F +  + P R+L +
Sbjct:  439 MCFACRDYSRGGRCVDSCNILEGEPREAVMNKTCVECDPECQRMNGTATCSGPGNCAKCANFQ-------DGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHK--NCTQGSTGLSMIAAGVVGGLLTVLVTGLSVFVLLRRRYIKRKRTMRRLLQE-----RELVEPLTPS------GQAPNQALLRILKESEF---KKIKVLGSGAFGTVYKGLW-VPEGED--VKIPVAIKVLREATSPKANKEILDEAYVMASVENPHVCRLLGICLT-STVQLITQLMPYGCLLDYVKEKKDNIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPNHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESILTRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGDRLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIGEFTKMARDPSRYLVI 884          

HSP 2 Score: 103.99 bits (258), Expect = 7.564e-22
Identity = 123/452 (27.21%), Postives = 178/452 (39.38%), Query Frame = 1
Query:  655 KCHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAP----RPN-HIFGMDSKDKLRYTVGGLCTSQCPAS-LLDQNKICVYECD---FDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXS-----FNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMN-IHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEISPDNRVKFSCNKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ-----NCTGPTPKNCGGQCRYAIEENTCVKNC-----SIDFFPVANNVNAPITCQLCHSSC 1926
            KCH+ C          +  C+ P    CQ  TK  C +    K CK     +  C+  CA GC G    DC  C     D  C  SC       PN H+   +   K  Y+ G  C   CP + ++  +  CV  C    ++  +    +C +C NG C     G    N+              S+N   +    NCT I G++     S     F K     P      K V+EI G   + T+   +S+L+   NLE IR   K  + + A+  +   Y+    LK++    G + I   +  CY +R  W+ +   ++ +   N TCD  C    CWGPG +MC++C  Y  G  CV  C+   G        KT  C  C P C++      C+G  P NC  +C    +   CV  C       D   V    +    CQLCH +C
Sbjct:  120 KCHSSC---------FNGSCWAPGPQYCQTLTKLNCAQQCS-KRCKGPSPSDC-CNEHCAAGCTGPRPTDCLACRDFRDDGVCKDSCPGLMRYDPNLHLLVPNPNGK--YSFGATCVKNCPHNYVVTDHGACVRTCSGNTYEVDEGGIRKCAKC-NGPCPKVCNGLGTGNLT----------HTLSINATNIDSFKNCTKINGNIAFIHTSIYGDKFTKTPKMDPAKLDVFKTVKEITGYLWIQTWPKNMSSLSPFENLEIIRGRTKQGSRSVAITQLDISYLGLRSLKEISD--GDVVIIKNHNLCYTNRSHWKGLF-KSKTQTLMNSTCDRKCAADGCWGPGPDMCFACRDYSRGGRCVDSCNILEGEPREAVMNKT--CVECDPECQRMNGTATCSG--PGNC-AKCANFQDGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNC 539          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Medaka
Match: ENSORLT00000004471.2 (melanoma receptor tyrosine-protein kinase [Source:NCBI gene;Acc:101169984])

HSP 1 Score: 270.781 bits (691), Expect = 1.126e-73
Identity = 172/558 (30.82%), Postives = 279/558 (50.00%), Query Frame = 1
Query: 2020 IKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKN---IVHQSS-CEPCHSMCRTCSGSTNEK-------RMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTAC-----TRCLNHKLFVDDDKNKFSCVTRCPH----DRNFT--EYQDGDFICLKFEE--------------TINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            ++  +N+ LC+  +            N S+L ++   IV Q+   + C    +TC    + K        MC  C+ +     CV+ C+ ++    ++E+   C +CH EC    L+   +  C      +C     F D       CV  CPH    D N    +Y D +  C    +              +  +        ++SG    ++ ++   V   R R  + R L  +              ++E  +  P       PN   ++++  ++       + LGSGAFG V++G W VP  +N  + + V IKV+  + S  +  E L+EA +MASV H H   L+G+CL+     LV+    +G L  Y++Q+  +I +  +L W  QIA GM YL +R ++HRDLAARNVL+ + ++I+ITDFGLA+L+   +       GKVPI+W+A+E++L  TY+  +DVW+YGVT+WE+ T+  +PY+ +A  EI + L++G RL QP I T++VYM+M+KCW+ DP  RP F EL+  F Q  + P R+L +
Sbjct:  484 VRLKDNKLLCYSKA-----------MNWSYLFRDKTQIVDQTPPVDVCEGQNQTCDQQCSSKGCWGPGTNMCLSCQYFNRKQHCVERCNLLQGEPREVEVEGSCVECHPEC----LVMTGTQTCHGPGPDQCSQCAHFKDGSH----CVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQGCSGPGLSGCSRTTTHSSLAVGVVSGLLVAVIVLLFVLVYVRRQRIKKKRTLRRL--------------LQEKELVEPLTPSGQAPNQALLRILKETEF---KKVRVLGSGAFGTVFKGLW-VPEGEN--VRIPVAIKVLREATSPKANQEVLDEAYVMASVDHPHVCRLLGICLT-SSVQLVTQLMPYGCLLDYVRQHKDRICAQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHIKITDFGLAKLLTADEKEYHADGGKVPIKWMALESILQWTYTHQSDVWSYGVTVWELMTFGSKPYDGIAASEIATVLERGERLPQPPICTIDVYMIMVKCWMIDPSSRPKFKELIMEFSQMARDPSRYLVI 1001          

HSP 2 Score: 147.132 bits (370), Expect = 4.963e-35
Identity = 157/598 (26.25%), Postives = 245/598 (40.97%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-------LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPT--TQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKL-----RYTVGGLCTSQCPASLLDQNKICVYECD---FDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNG-VTVPML----YHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIR-----LSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI----------SPDNRVKFSCNKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLC-----RQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNV-----NAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSK 2007
            NDV  +PL NL++IRG  L ++   L + + HS N T        L ++ L  L  I++  V ++ NP L  +EK + W  I+D     +  LK  ++ R          +CE    + G  +  C+    + CQK TK  C +      C   K  +  C+  CA GC G  + DC  C     D  C  SC P   +++   S+  +     +Y+ G  C   CP + +     CV  C    ++  +    RC  C  G C       K C+   + +         ++N   +    NCT I GD+     SF+ +    +P +      + + V+EI G   + T+   +++L+   NLE IR     ++  S  V  A N+H   +  L         G + +      CY   + W  +          +P   V    N+TCD  C+ + CWGPG  MC SC Y+     CV++C+   G    + E +   C  CHP C      Q C GP P  C  QC +  + + CV+ C        N +     +    CQLCH +C         +  C+GP    G  GCS+
Sbjct:  109 NDVATVPLVNLRLIRGQNLYDKFALLVMSNYHSNNITGAPRYTSGLRQLQLSRLTEILNGGVKVTNNPLLCNMEK-IQWWDIVDKARNFSVLLKFDDYKR----------DCERC--DPGCVNDSCWAAGPDHCQKFTKLVCAEQCGPGRCSGPKPLDC-CNQHCAAGCTGPLATDCLACKNFNDDGICKDSCPPL--NLYNHKSQQVVENPNAKYSFGATCVKACPHNYVVTEGSCVRACSPNTYEVEENGVQRCKRC-EGPCP------KACDGVGVGRL----TNTIAVNSSNIESFRNCTKINGDIVFLKSSFSGDQHYNIPPMDPKKLEYFRTVKEITGHLLIQTWPENMTSLSVFENLEIIRGRSLFVNKYSFVVVGADNLHWLGLRSLKELSA----GNVRLKDNKLLCYSKAMNWSYLFRDKTQIVDQTPPVDVCEGQNQTCDQQCSSKGCWGPGTNMCLSCQYFNRKQHCVERCNLLQGE-PREVEVEG-SCVECHPECLVMTGTQTCHGPGPDQC-SQCAHFKDGSHCVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNC---------SQGCSGP----GLSGCSR 659          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Medaka
Match: ENSORLT00000004469.2 (melanoma receptor tyrosine-protein kinase [Source:NCBI gene;Acc:101169984])

HSP 1 Score: 270.396 bits (690), Expect = 1.365e-73
Identity = 159/488 (32.58%), Postives = 253/488 (51.84%), Query Frame = 1
Query: 2197 MCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTAC-----TRCLNHKLFVDDDKNKFSCVTRCPH----DRNFT--EYQDGDFICLKFEE--------------TINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRP-------PNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            MC  C+ +     CV+ C+ ++    ++E+   C +CH EC    L+   +  C      +C     F D       CV  CPH    D N    +Y D +  C    +              +  +        ++SG    ++ ++   V   R R  + R L  +              ++E  +  P       PN   ++++  ++       + LGSGAFG V++G W VP  +N  + + V IKV+  + S  +  E L+EA +MASV H H   L+G+CL+     LV+    +G L  Y++Q+  +I +  +L W  QIA GM YL +R ++HRDLAARNVL+ + ++I+ITDFGLA+L+   +       GKVPI+W+A+E++L  TY+  +DVW+YGVT+WE+ T+  +PY+ +A  EI + L++G RL QP I T++VYM+M+KCW+ DP  RP F EL+  F Q  + P R+L +
Sbjct:  533 MCLSCQYFNRKQHCVERCNLLQGEPREVEVEGSCVECHPEC----LVMTGTQTCHGPGPDQCSQCAHFKDGSH----CVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQGCSGPGLSGCSRTTTHSSLAVGVVSGLLVAVIVLLFVLVYVRRQRIKKKRTLRRL--------------LQEKELVEPLTPSGQAPNQALLRILKETEF---KKVRVLGSGAFGTVFKGLW-VPEGEN--VRIPVAIKVLREATSPKANQEVLDEAYVMASVDHPHVCRLLGICLT-SSVQLVTQLMPYGCLLDYVRQHKDRICAQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHIKITDFGLAKLLTADEKEYHADGGKVPIKWMALESILQWTYTHQSDVWSYGVTVWELMTFGSKPYDGIAASEIATVLERGERLPQPPICTIDVYMIMVKCWMIDPSSRPKFKELIMEFSQMARDPSRYLVI 991          

HSP 2 Score: 147.902 bits (372), Expect = 3.258e-35
Identity = 156/591 (26.40%), Postives = 244/591 (41.29%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-------LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPT--TQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKL-----RYTVGGLCTSQCPASLLDQNKICVYECD---FDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNG-VTVPML----YHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIR-----LSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEISPDNRV---KFSCNKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLC-----RQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNV-----NAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSK 2007
            NDV  +PL NL++IRG  L ++   L + + HS N T        L ++ L  L  I++  V ++ NP L  +EK + W  I+D     +  LK  ++ R          +CE    + G  +  C+    + CQK TK  C +      C   K  +  C+  CA GC G  + DC  C     D  C  SC P   +++   S+  +     +Y+ G  C   CP + +     CV  C    ++  +    RC  C  G C       K C+   + +         ++N   +    NCT I GD+     SF+ +    +P +      + + V+EI G   + T+   +++L+   NLE IR     ++  S  V  A N+H   +  L         G + +      CY   + W  +  D      +   N+TCD  C+ + CWGPG  MC SC Y+     CV++C+   G    + E +   C  CHP C      Q C GP P  C  QC +  + + CV+ C        N +     +    CQLCH +C         +  C+GP    G  GCS+
Sbjct:  106 NDVATVPLVNLRLIRGQNLYDKFALLVMSNYHSNNITGAPRYTSGLRQLQLSRLTEILNGGVKVTNNPLLCNMEK-IQWWDIVDKARNFSVLLKFDDYKR----------DCERC--DPGCVNDSCWAAGPDHCQKFTKLVCAEQCGPGRCSGPKPLDC-CNQHCAAGCTGPLATDCLACKNFNDDGICKDSCPPL--NLYNHKSQQVVENPNAKYSFGATCVKACPHNYVVTEGSCVRACSPNTYEVEENGVQRCKRC-EGPCP------KACDGVGVGRL----TNTIAVNSSNIESFRNCTKINGDIVFLKSSFSGDQHYNIPPMDPKKLEYFRTVKEITGHLLIQTWPENMTSLSVFENLEIIRGRSLFVNKYSFVVVGADNLHWLGLRSLKELSA----GNVRLKDNKLLCYSKAMNWSYLFRDKTQIVDQTPPNQTCDQQCSSKGCWGPGTNMCLSCQYFNRKQHCVERCNLLQGE-PREVEVEG-SCVECHPECLVMTGTQTCHGPGPDQC-SQCAHFKDGSHCVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNC---------SQGCSGP----GLSGCSR 649          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Medaka
Match: egfra (epidermal growth factor receptor [Source:NCBI gene;Acc:101159776])

HSP 1 Score: 270.011 bits (689), Expect = 2.155e-73
Identity = 160/486 (32.92%), Postives = 253/486 (52.06%), Query Frame = 1
Query: 2197 MCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECR--NGCLL--ANDSTACTRCLNHKLFVDDDKNKFSCVTRCPH------DRNFTEYQDGDFICLKFEETINS------------KQRKTIFIILSGCFGFL--VFIIGFCVL------YFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNS-SKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            MC  C+ Y    +CV  C+ ++    +  +   C +C  EC+  NG     A+    C +C N +       +   CV+RCP       D    +Y D   +C    +                K    + +I +G  G L  V + G  V       Y + +    R+L E + +     EP   + +       PN   ++++  S+       K LGSGAFG VY+G W VP  ++  + + V IKV+  + S  +  E L+EA +MASV + H   L+G+CL+     L++    +G L  Y+++    I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++++ITDFGLA+L++  +       GKVPI+W+A+E++L+ TY+  +DVW+YGVT+WE+ T+  +PY+ +   EI   L++G+RL QP I T++VYM+M+KCW+ D   RP F EL+  F +  + P R+L +
Sbjct:  514 MCFACRDYSRGGRCVDSCNILEGEPREAVMNKTCVECDPECQRMNGTATCSASGPGNCAKCANFQ-------DGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQGCTGPGLKGCHIKSSTGLSMIAAGVVGGLLTVLVTGLSVFVLLRRRYIKRKRTMRRLLQERELV-----EPLTPSGQA------PNQALLRILKESEF---KKIKVLGSGAFGTVYKGLW-VPEGED--VKIPVAIKVLREATSPKANKEILDEAYVMASVENPHVCRLLGICLT-STVQLITQLMPYGCLLDYVKEKKDNIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPNHVKITDFGLAKLLNADEKEYHADGGKVPIKWMALESILTRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGDRLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIGEFTKMARDPSRYLVI 974          

HSP 2 Score: 118.627 bits (296), Expect = 2.636e-26
Identity = 159/588 (27.04%), Postives = 229/588 (38.95%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGT--AKCHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAP----RPN-HIFGMDSKDKLRYTVGGLCTSQCPAS-LLDQNKICVYECD---FDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXS-----FNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMN-IHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI---------SPDNRVKFSC---NKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQ-----NCTGPTPKNCGGQCRYAIEENTCVKNC-----SIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGC 2001
            N   RIPL NL++IRG +L     AL+++ N S+ GT   E+ L  L  I++  +    N       + + W  I++     K+   E    SN     KCH+ C          +  C+ P    CQ  TK  C +    K CK     +  C+  CA GC G    DC  C     D  C  SC       PN H+   +   K  Y+ G  C   CP + ++  +  CV  C    ++  +    +C +C NG C     G    N+              S+N   +    NCT I G++     S     F K     P      K V+EI G   + T+   +S+L+   NLE IR   K  + + A+  +   Y+    LK++    G + I   +  CY +R  W+ +           +N    +C   N TCD  C    CWGPG +MC++C  Y  G  CV  C+   G        KT  C  C P C++      C+   P NC  +C    +   CV  C       D   V    +    CQLCH +C            CTGP    G  GC
Sbjct:   89 NTATRIPLENLRIIRGHSLYEGEFALSVLVN-SDKGTGTTELLLTKLTEILAGGIKFGNNQLCNV--ETIQWFDIVNPDKKPKM---ELPMASNNPLCKKCHSSC---------FNGSCWAPGPQYCQTLTKLNCAQQCS-KRCKGPSPSDC-CNEHCAAGCTGPRPTDCLACRDFRDDGVCKDSCPGLMRYDPNLHLLVPNPNGK--YSFGATCVKNCPHNYVVTDHGACVRTCSGNTYEVDEGGIRKCAKC-NGPCPKVCNGLGTGNLT----------HTLSINATNIDSFKNCTKINGNIAFIHTSIYGDKFTKTPKMDPAKLDVFKTVKEITGYLWIQTWPKNMSSLSPFENLEIIRGRTKQGSRSVAITQLDISYLGLRSLKEISD--GDVVIIKNHNLCYTNRSHWKGLFKSKTQSANVDENASATACALMNSTCDRKCAADGCWGPGPDMCFACRDYSRGGRCVDSCNILEGEPREAVMNKT--CVECDPECQRMNGTATCSASGPGNC-AKCANFQDGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNC---------TQGCTGP----GLKGC 628          
BLAST of epidermal growth factor receptor 3 vs. Ensembl Medaka
Match: erbb4b (erb-b2 receptor tyrosine kinase 4 [Source:NCBI gene;Acc:101165111])

HSP 1 Score: 266.159 bits (679), Expect = 6.559e-72
Identity = 166/499 (33.27%), Postives = 261/499 (52.30%), Query Frame = 1
Query: 2149 CHSMCR--TCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNG---CLLANDSTA--CTRCLNHKLFVDDDKNKFSCVTRCPHDRN-----FTEYQDGDFIC-------------LKFEETINSKQRKTIFIILSGCFG--FLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYM 3561
            C  +C    C GS  ++  C  CK +     C+K C+  +    +   G  C +C  +C  G    L  + S    C +CL+ K    D  N   CV +CP           +Y + +  C              + ++ I    R  +  I +G  G  F+V I+   V     R N  +  A  + L +   EP   +         PN  +++++  ++L      K LGSGAFG VY+G W +P  + + + + V IK+++ ++    + EF++EA IMAS+ H H + L+GVCLS     LV+    HG L  Y+ ++   I S  +L W  QIA GM YL +R ++HRDLAARNVLV   ++++ITDFGLARL+D  +       GK+PI+W+A+E +    ++  +DVW+YGVT+WE+ T+  +PY+ ++T +I   L++G RL QP I T++VYMVM+KCW+ D   RP F EL + F +  + P+R+L +
Sbjct:  460 CDPLCSDDGCWGSGPDQ--CLSCKFFSRGRSCIKSCNLYQGEIREYANGSVCVECDSQCEQGDDNTLTCHGSGPEHCVKCLHFK----DGPN---CVEKCPDGLQGASSFIFKYAEANNECHPCHPNCTQGCIGPRLQDCIGWMDRTPL--IAAGVIGGLFMVVIMALSVAVSVRRKNIKKKRALRRFLETELVEPLTPSGTA------PNQAQLRILKETEL---KRIKILGSGAFGTVYKGIW-IP--EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLDVNEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFTRMARDPQRYLVI 934          

HSP 2 Score: 133.265 bits (334), Expect = 1.092e-30
Identity = 160/618 (25.89%), Postives = 244/618 (39.48%), Query Frame = 1
Query:  235 QRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTF-LEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTA---KCHTECEYWTREDGVRSQFCFGPSKNECQKQTK--CVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP----NHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI--SPDNRVKFSCNK----------TCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQN------CTGPTPKNCGGQCRYAIEENTCVKNCS---------IDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGP 1974
            + C  + GNL I+ + R +N     L+FL SI E++G + +  N    +PL NL++IRG  L  +  +L I  N+  +G F L  + L NL  I+   V + QN  L + +  + W  I+ +P    + V     P+N +    KCH  C          +  C+GP  N+CQ  TK  C +  D + C      +  C  ECAGGC G    DC  C        CV+ C P+P       F ++     RYT G  C  +CP             CD                G    +    +  + + IDKF   N  K + N   L+     T I GD+  +  + +   + V       ++VREI G  ++ ++   +++L   SNL  I        ++  +        FL     +   G + I      CY + + W  +  SP+ +V    N+           CDPLC+   CWG G + C SC ++  G SC+K C+   G            C  C   C Q       C G  P++C  +C +  +   CV+ C          I  +  ANN      C  CH +C            C GP
Sbjct:   50 ENCEVVMGNLEITSIDRSRN-----LTFLRSIREVTGYVLVALNQFDHLPLENLRIIRGTKLYEDRYSLAIFLNYRRDGNFGLRHLGLINLAEILYGGVYVDQNKFLCHAD-TIHWQDIVKNPGFHPVVV-----PTNSSVTCPKCHRSC----------NGRCWGPKDNQCQSLTKTVCAEQCDGR-CSGPYVSDC-CHRECAGGCFGPKDTDCFACTNFNDSGACVTQC-PQPFFYNPTTFQLEHNPSARYTYGAFCVKKCPP------------CD----------------GIGTGTLQAAQTVDSSNIDKFV--NCTKINGNLVFLI-----TGIKGDVYHNIEALDPEKLNV------FRSVREITGYLNIQSWPDNMTDLIVFSNLATIGGRALYSGISLLVLKQQGISSFLLQSLKEISAGNVHIAENKQLCYYNTVNWTRLFRSPNQKVLVRNNRNPLECARGHMVCDPLCSDDGCWGSGPDQCLSCKFFSRGRSCIKSCNLYQGEIREYANGSV--CVECDSQCEQGDDNTLTCHGSGPEHC-VKCLHFKDGPNCVEKCPDGLQGASSFIFKYAEANN-----ECHPCHPNC---------TQGCIGP 585          
BLAST of epidermal growth factor receptor 3 vs. Planmine SMEST
Match: SMESG000016935.1 (SMESG000016935.1)

HSP 1 Score: 2954.47 bits (7658), Expect = 0.000e+0
Identity = 1459/1469 (99.32%), Postives = 1464/1469 (99.66%), Query Frame = 1
Query:   64 MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEISPDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISLERIKNFSKFDLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQRSNEYDTQPVNPQIAKLRKEIKHNNSLYDGSSKSDNTFKIPERIFIDKSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNPQFESIKSSVGNRIENSPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAVLNKEYIDDDGYLEPKKFDR 4470
            MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAY YLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWT EDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCN+ATIDKFYPKNNRKYSLNKQTLMQLTNCTLILGDLDIDDISFNKNGVTVPMLYHHLKNVREIIGLFSLVTF+TKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFLGLKKLKKVYGKISIGGTNGTCYLDRIPWEEISPDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKT+NNQYLCHKGSCPKGFYQSVINQNISHLHK IVHQSSCEPCHSMCRTCSG TNEKRMCHQCKGYFLDNKCVKECDNMKNVT+KLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISLERIKNFSK DLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQRSNEYDTQPVNPQIAKLRKEIKHNNSLYDGSSKS+NTFKIPERIFIDKSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNPQFESIKSSVGNRIENSPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAVLNKEYIDDDGYLEPKKFDR
Sbjct:    1 MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYKYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTGEDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNLATIDKFYPKNNRKYSLNKQTLMQLTNCTLILGDLDIDDISFNKNGVTVPMLYHHLKNVREIIGLFSLVTFRTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFLGLKKLKKVYGKISIGGTNGTCYLDRIPWEEISPDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTSNNQYLCHKGSCPKGFYQSVINQNISHLHKKIVHQSSCEPCHSMCRTCSGPTNEKRMCHQCKGYFLDNKCVKECDNMKNVTMKLEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISLERIKNFSKLDLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQRSNEYDTQPVNPQIAKLRKEIKHNNSLYDGSSKSNNTFKIPERIFIDKSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNPQFESIKSSVGNRIENSPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAVLNKEYIDDDGYLEPKKFDR 1469          
BLAST of epidermal growth factor receptor 3 vs. Planmine SMEST
Match: SMESG000005947.1 (SMESG000005947.1)

HSP 1 Score: 691.419 bits (1783), Expect = 0.000e+0
Identity = 447/1203 (37.16%), Postives = 647/1203 (53.78%), Query Frame = 1
Query:   67 HLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAH-GSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVT--LRNEPDALNIIHNHSENG-TFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVK--NKDLKWCKFTKTGEIPC-SHECAGGCDGRTSKDCTVCNKLVKDSDCVSSC-APRPNHIFGMDSKDKLRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYI-----EFXXXXXXXXVYGKISIGGTNGTCYLDRIPWEEI---------SPDNRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYF--ASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQ-NISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKL-EIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQ--DGDFICLKFEET---INSKQRKTIFI-ILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQDNKYIN-------LEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDET-DDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFL 3555
            +L+LF  +  I    N + F  +YP   IC        S  +  E    L  ++   + CTHI G++ I  +++ +  S       +SI EI G L I  ND+++I   NL++IRG     RN  D  +   +   +G   L ++D R+LR+I + NVI   NP ++YL  ++ W+++  DP  Q L      +      KC  +C+ W     V   FC+GPS N+CQ+QT C    + +   C++    E  C + +C GGC+G  +  CT C  ++    CV  C  P    I G  +  + RY  G  C+ QCPA +L +N  CV++C     +   N CI+C    C   T  +  CN+  I       N  Y L  Q L+QL NC  ILG + + + SF K+ +TV MLY +L  ++E+ G FS       + NLTFL NL   R +     + +  + H   I     EFLGLK LK++ G          CY++ IP  E+          P N     C+K C       CWGPGN++CY C  Y A  +CV  CS   G++   + +     KC  CHP C   C GP P  C   C+   E  TCV +CS +F+P  N+  A   C  CH +C    + +     CTGPS++ G GGC+KCE+++ +     +    +C +G Y    ++ +IS  +   V   +C PC  +C  C G + +   C  CKG +  N C   C   ++   K+ +    C  CH  C+ GC   +    CTRC N K+++D  K KF C   CP  ++  E +   GD +CL   E+   +   +R  I + ++      ++ +I   V+Y + +A   RI  E+KA YSN  EP+ K+  ED +++PPNM R+ ++   DL+F+  SKPLG GAFG VY+G WK+P+ +   +        L V IKVI N      +  ++EAK+MASVSH HCL  IGVCLS EKPCL+S Y + GSLDK+L +N  KI+S  ML W++QIADGM YL KR IIHRDLAARNVLV+  + +QITDFGL+++++ T D  I+IK+GKVPIRWLAIETL    YS  TDVWA+GVTLWEIFT+ K PYE+ AT +I  F+ +G RL QP+I +L+VY++M+ CWL+ P++RP F  L+ TF  + ++P R+L
Sbjct:    6 YLILF--LFLIQFQINNATFEEEYPGTIICQNDNVQIESLHSSVEKLKIL--SIIRSKNCTHIQGSIYILGITKLE--SKERELNFDSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQV---FCWGPSANQCQQQTLCGSKYSSECTTCRYINGEEQGCCNDQCLGGCNGGGASKCTACKNMLNKKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPAMMLPENTGCVHKCSEGYFKNKSNHCIKCYGNMC---TNDHLPCNLFKIAGHTDGANDFY-LRAQDLVQLKNCKKILGYIVLTEDSFVKHNITVEMLYENLNKLQELEGGFSYFK-DNHLKNLTFLRNLLRFRAAYLHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCYMN-IPVNELFKNVKNFYYIPSNCTDKICHKDCS---EKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQKCLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKA---CLPCHPNCSEYNSTI-----CTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYP--VTGFTCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRCPKDESYGTKIIDSISYCKTCHSSCK-GCY-GSTIFNCTRCKNKKIYLD--KKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHITVGVVVTMLILVIIVIVTIVVYLKRKAIAERIETELKARYSNLTEPNSKD--EDLLSKPPNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKDKEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAFGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYL 1174          
BLAST of epidermal growth factor receptor 3 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1)

HSP 1 Score: 581.252 bits (1497), Expect = 0.000e+0
Identity = 441/1379 (31.98%), Postives = 678/1379 (49.17%), Query Frame = 1
Query:   64 MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSE---------NGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTG-EIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP--NHIFGMDSKDK-LRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLC-NIATIDKFYPKNNRKYS---LNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPML-----YHHLKNVREIIG--LFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGK-ISIGGTNGTCYLDRIPWEEISPDNRVK----FSCNKTCDP--------LCTGQC------WGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQY-LCHKGSCPKGFYQSVINQNISHLHKNIVHQSS-----CEPCHSMCRTCSGSTNEK--------RMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGD---ECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPR---QDNKYIN------LEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAK-------RNISLERIKNFSKFDLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQ 3972
            +H+LL  ++ +       S+   +YP  + C  S         +++  Y      LG  CTH+YGN+ I+++    NGS+PDL FL  I EI+GSL I N+++  +PL NL+VIRG +     D++  + N  E         + +    IDLR+LR+I+S N+ IS          N++W+++L+DPT Q +      +P+  + KC  +          +S FC+GP  ++CQ  +KC K      C  ++TG E  C+ +C GGC    S  C  C  ++ ++ C   C P+   N   G+   +K  R     +C ++CP  LL+Q   C  +C F  +++ G++C+ C             LC  I T+++ +  N+ KYS   L+   L +L NCT   G + ID  SF K+   +  +        L+N+R I G     L     K+ +L+FLSNL+ I   V    +++++ I    I +LGLK LK +  K I        CY D   ++ I   + +      S N   DP        +C+ QC      WGPG   C SCA  + G  C + C   PGY  +      + C  CH  C + C+G     C G C++A+E + CV+ CS   F   N +    TC+ CH  C      +     CTGPSN  G GGC+KC+ +I   + Q   C++ +   G++        S  H N + + +      EPCH +C  C+  T+++        + C QCKGY+ D+KCV  C  ++      E      +C  CH +C NGC    D+  C  C N KL  +++   FSCV  CP +   T     + IC+     +     +   +IL+  F F++  +   +  F    N  R   ++KA +SN KE D +         PPNM  + +I   +L F    + LG G FG VY G WK+      DN  +N      ++VVIKV+++S     +EF++E +IMASV H+HCL LIGV     +  L+S+Y   GS++KYL++N K ++   +LKWA+QIA+GM YL    IIHRDLA RNVL+  ++++QITDFGL+++++   D + I  G VP+RWLAIETL    YS  TDVWAY VTLWEIFT+A  PYE L   EI+  + +G RL QP+I +L++Y++M+KCW  DP  RP+F  L + F+ +  + + +L  P+  V Q Y K       I++ Q                 DE S+ A    N +   +I N   + + KS +      +       RN+  E + NFSK   N  L+   ++ + N NY    +      +  +I+   P  T+
Sbjct:   11 LHILLISLIFY-----RYSDSLIEYPEIKYCFSSM---DLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSL--ANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQK---------GKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCK-----------ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP--IISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKV-CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHF--LNKITK--TCEPCHKDCHSRS--ITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC-NGCY-GVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICV----FVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQT------PSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC--DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--VEQNY-KTNTFNNYIEIKQ---------------HEDEISYDAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLTEPPIRNLLYEPV-NFSKTS-NITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTR 1316          
BLAST of epidermal growth factor receptor 3 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1)

HSP 1 Score: 578.556 bits (1490), Expect = 0.000e+0
Identity = 437/1356 (32.23%), Postives = 668/1356 (49.26%), Query Frame = 1
Query:  133 DYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDXXXXXXXXXXXXXXXXXNNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSE---------NGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTG-EIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRP--NHIFGMDSKDK-LRYTVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLC-NIATIDKFYPKNNRKYS---LNKQTLMQLTNCTXXXXXXXXXXXSFNKNGVTVPML-----YHHLKNVREIIG--LFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFXXXXXXXXVYGK-ISIGGTNGTCYLDRIPWEEISPDNRVK----FSCNKTCDP--------LCTGQC------WGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQY-LCHKGSCPKGFYQSVINQNISHLHKNIVHQSS-----CEPCHSMCRTCSGSTNEK--------RMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGD---ECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPR---QDNKYIN------LEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPISIRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAK-------RNISLERIKNFSKFDLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPFYTQ 3972
            +YP  + C  S         +++  Y      LG  CTH+YGN+ I+++    NGS+PDL FL  I EI+GSL I N+++  +PL NL+VIRG +     D++  + N  E         + +    IDLR+LR+I+S N+ IS          N++W+++L+DPT Q +      +P+  + KC  +          +S FC+GP  ++CQ  +KC K      C  ++TG E  C+ +C GGC    S  C  C  ++ ++ C   C P+   N   G+   +K  R     +C ++CP  LL+Q   C  +C F  +++ G++C+ C             LC  I T+++ +  N+ KYS   L+   L +L NCT   G + ID  SF K+   +  +        L+N+R I G     L     K+ +L+FLSNL+ I   V    +++++ I    I +LGLK LK +  K I        CY D   ++ I   + +      S N   DP        +C+ QC      WGPG   C SCA  + G  C + C   PGY  +      + C  CH  C + C+G     C G C++A+E + CV+ CS   F   N +    TC+ CH  C      +     CTGPSN  G GGC+KC+ +I   + Q   C++ +   G++        S  H N + + +      EPCH +C  C+  T+++        + C QCKGY+ D+KCV  C  ++      E      +C  CH +C NGC    D+  C  C N KL  +++   FSCV  CP +   T     + IC+     +     +   +IL+  F F++  +   +  F    N  R   ++KA +SN KE D +         PPNM  + +I   +L F    + LG G FG VY G WK+      DN  +N      ++VVIKV+++S     +EF++E +IMASV H+HCL LIGV     +  L+S+Y   GS++KYL++N K ++   +LKWA+QIA+GM YL    IIHRDLA RNVL+  ++++QITDFGL+++++   D + I  G VP+RWLAIETL    YS  TDVWAY VTLWEIFT+A  PYE L   EI+  + +G RL QP+I +L++Y++M+KCW  DP  RP+F  L + F+ +  + + +L  P+  V Q Y K       I++ Q                 DE S+ A    N +   +I N   + + KS +      +       RN+  E + NFSK   N  L+   ++ + N NY    +      +  +I+   P  T+
Sbjct:   37 EYPEIKYCFSSM---DLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSL--ANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQK---------GKSGFCWGPLTSQCQIFSKCRKRMCANRCFLSETGDEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCPEGLLEQEGECKTQCTFRKYERQGDQCVPCK-----------ILCEQICTLEEIFSPNDFKYSYFSLDYPKLKKLANCTTFKGFVQIDTESFVKHRPEIVPISNSDDLKFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP--IISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSKV-CLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHF--LNKITK--TCEPCHKDCHSRS--ITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQC-NGCY-GVDNNHCIHCNNFKLPENENLTLFSCVESCPSNYKETSGNSNENICV----FVFLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQT------PSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVLNHSC--DQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIINPNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN--VEQNY-KTNTFNNYIEIKQ---------------HEDEISYDAPHSPNQNRVRVIGNMRPRGNQKSIIVPEHVQRFLTEPPIRNLLYEPV-NFSKTS-NITLNGSFNKSNGNTNYHDFHSRPDVSPSSLTIEYLEPLTTR 1324          
BLAST of epidermal growth factor receptor 3 vs. Planmine SMEST
Match: SMESG000044603.1 (SMESG000044603.1)

HSP 1 Score: 448.358 bits (1152), Expect = 1.512e-132
Identity = 356/1180 (30.17%), Postives = 555/1180 (47.03%), Query Frame = 1
Query:  364 NDVKRIPLTNLKVIRG---VTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRP----SNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQK-----------QTKCVKNKDLKWCKFTKTGEIPCSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKLRYTVGGL-----CTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTXXXXXXXXXXXSFN---------KNGVTVPMLYHHLKNVREIIGLFSL-VTFQTKISN-LTFLSNLEEIRL-SVKSHTVASAMNIHGKYIEFXXXXXXXXVY-GKISIGGTNGTCYLDRIPWEEI-------SPDNRVKFSCNKT-CDPLCTGQ--CWGPGNEMCYSCAYY--KAGNSCVKQCSDSPGYFASQTEFKTI--KCQTCHPLCR---QNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNN-----------NQYLCHKGS--CPKGFYQSVINQNISHLHKNIVHQSS---------------------CEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIK--LEIGDECPQCHKECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDGDFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWK------------VPRQDNKY-----INLEVVIKVIHNSSKGSTD-EFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQ 3582
            N V+ I L  LKVIRG   + ++    +L + +N     + LE I   NL+ I+  NV  + NP L Y  + ++W+ ++    +Q++ + E        +N    CH  C+       +   +C+G S + CQK            TKC  N+ LK        E  C  EC GGC G     C  C     +  CV +C P   H    D    ++  +G L     C  +CP    +++  CV +C  +    +   C+ CPNG C       K+C    I      +     ++++ L +L NCT+  G++ I+  S           +N          L+N+ EI G   + V F +  ++ L FL NL  IR  +V+SH       +    +++LGL+ LK+V  G I I   N  C+ + +  + I          N  K +C+K  C   C  +  CWGP    C  C  +  +   +C+ +CS+ PGYF + +    +   C  CH  C      C G     C   C+      +C+K C   ++     V++   C  CH++C  +         C GP + LG  GCS C  +I ++N           N   C K S  CPKGFY+S+I+   S +  N   QS+                     C PCH  C  C G ++    C  CK +  DNKC+++C     +T+    +   EC +CH+EC  GCL  + +  C RC + K++V+    +F C + C  DR    +Q  + IC   +  I S  R  ++I + G  G ++  +   V +     NQ +          +F   D            PNM  + +I  S L   T  + +GSGAFG VY+G W+            + R  +K      I L V +K++ + S  S + E LEEAK+MASV H  CL ++ VCL+   P L++ +   GSL +++Q+N   I+S ++L WAKQIA GM YL  +GIIH DLAARNVL+     ++ITDFGLA+++D +      K G++PI+WLA+E + +  +S  +DVW+YGVTLWE+F+Y ++P+ ++   +I   L++G RL QP+I +++ Y ++++CWL DP  RPSF EL  TFE    +P R+L +  E  N+
Sbjct:  136 NAVESISLIKLKVIRGENPLLIKGLKFSLIVGYN-----SMLENILFPNLQVILRHNVFFNNNPKLCYASRKINWNSLMR--RSQEVVIVETNEKDCGLNNEELSCHESCQ-----AHLNKTYCWGNSSSACQKINDCANRTCYDSTKCYINEILK-------TEECCHEECVGGCTGPARSQCLACKNFNNNGICVENCPPEFKH----DGMKYIQNPLGKLAFYYICVDKCPKKFFNEHGNCVTQCSAEKTYAVNQTCVPCPNGKCP------KICRARDI----LDSQEISYVHRKVLGRLENCTVYDGNILINRFSLEGDNFHNLSKQNDGIRKQDLKKLENLEEIYGYLRIHVPFNSNWTDSLEFLKNLRIIRAENVRSHKSRGIEIVGNPALKYLGLRNLKEVRNGNIIIFSNNQLCFSNTLTNKSILHKGTFLRALNGKKGNCSKKKCHSECEQRLGCWGPEKYHCVKCKSFVIRESKTCLSKCSNEPGYFYNSSSDHEVNRSCSRCHSECLPGINTCHGSNENECNLGCKNYKFGESCIKKCPAKYY-----VDSMKNCYPCHTNCTENSQ--NKESMCHGPEDSLGQKGCSICNHIIVSSNHSTSYKNSSNFNILKCLKNSDICPKGFYKSIIDFR-SGMKVNAAMQSTMKILEKWIEIGTNHDLPIASVCFPCHPYCSECHGGSSWH--CSLCKYFRSDNKCIQKCPKEYFITVNETAKPESECKKCHEECSEGCL-GSTNYDCLRCKHAKIYVNGS-TQFFCNSTCG-DR-IQLFQTSEIICT--DHLIYS--RFNMYIYIGGPAGIVICFVFIIVCFILSSKNQEKKFKTKLVNQGDFYPSDTGTNS----GVLPNMATLLLITESQL---TRQEIIGSGAFGIVYKGIWQPNIDAIDKSNSFLKRNISKISQDSSIKLNVAVKILTDISDPSNNREILEEAKVMASVDHPCCLRILAVCLTAH-PKLITQFMPLGSLLEFVQRNRSLINSITLLIWAKQIASGMEYLESKGIIHCDLAARNVLIQSPRQVKITDFGLAKMLDYSQQQYQFKGGRMPIKWLAVECIRNRIFSSKSDVWSYGVTLWEMFSYGEKPFADIKAYDILEHLEKGQRLNQPKICSIDAYTILVQCWLVDPDARPSFTELRKTFEMMSSNPNRYLLVQDEDSNE 1256          
The following BLAST results are available for this feature:
BLAST of epidermal growth factor receptor 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ERBB46.994e-7131.33erb-b2 receptor tyrosine kinase 4 [Source:HGNC Sym... [more]
ERBB49.509e-7131.33erb-b2 receptor tyrosine kinase 4 [Source:HGNC Sym... [more]
ERBB49.695e-7131.33erb-b2 receptor tyrosine kinase 4 [Source:HGNC Sym... [more]
ERBB21.867e-7031.42erb-b2 receptor tyrosine kinase 2 [Source:HGNC Sym... [more]
ERBB25.945e-7031.42erb-b2 receptor tyrosine kinase 2 [Source:HGNC Sym... [more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
let-231.480e-13429.93Receptor tyrosine-protein kinase let-23 [Source:U... [more]
let-235.797e-13429.93Receptor tyrosine-protein kinase let-23 [Source:U... [more]
let-238.239e-13429.93Receptor tyrosine-protein kinase let-23 [Source:U... [more]
let-239.602e-13429.93Receptor tyrosine-protein kinase let-23 [Source:U... [more]
R151.11.229e-4536.74pep chromosome:WBcel235:III:7218813:7221186:1 gene... [more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Egfr2.006e-12827.70gene:FBgn0003731 transcript:FBtr0071653[more]
Egfr1.085e-12728.03gene:FBgn0003731 transcript:FBtr0071654[more]
Eph4.057e-4933.02gene:FBgn0025936 transcript:FBtr0301285[more]
Eph4.336e-4933.02gene:FBgn0025936 transcript:FBtr0089085[more]
Eph4.614e-4933.02gene:FBgn0025936 transcript:FBtr0089084[more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
erbb4a3.533e-9327.23erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Ac... [more]
egfra1.362e-7232.67epidermal growth factor receptor a (erythroblastic... [more]
si:ch73-383l1.17.531e-7232.41si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-6... [more]
erbb21.527e-7131.65erb-b2 receptor tyrosine kinase 2 [Source:ZFIN;Acc... [more]
erbb21.527e-7131.65erb-b2 receptor tyrosine kinase 2 [Source:ZFIN;Acc... [more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gnb51.822e-7332.39guanine nucleotide binding protein (G protein), be... [more]
gnb52.408e-7332.60guanine nucleotide binding protein (G protein), be... [more]
gnb52.464e-7332.98guanine nucleotide binding protein (G protein), be... [more]
gnb51.169e-7131.94guanine nucleotide binding protein (G protein), be... [more]
gnb51.458e-7131.94guanine nucleotide binding protein (G protein), be... [more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Erbb24.551e-7331.26erb-b2 receptor tyrosine kinase 2 [Source:MGI Symb... [more]
Erbb43.225e-7030.90erb-b2 receptor tyrosine kinase 4 [Source:MGI Symb... [more]
Erbb43.296e-7030.90erb-b2 receptor tyrosine kinase 4 [Source:MGI Symb... [more]
Egfr1.721e-6831.43epidermal growth factor receptor [Source:MGI Symbo... [more]
Erbb38.393e-6330.24erb-b2 receptor tyrosine kinase 3 [Source:MGI Symb... [more]
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BLAST of epidermal growth factor receptor 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P0CY46|EGFR_APIME1.201e-13229.91Epidermal growth factor receptor OS=Apis mellifera... [more]
sp|P24348|LET23_CAEEL1.221e-13229.93Receptor tyrosine-protein kinase let-23 OS=Caenorh... [more]
sp|P04412|EGFR_DROME6.728e-12327.81Epidermal growth factor receptor OS=Drosophila mel... [more]
sp|P13388|XMRK_XIPMA2.908e-7433.82Melanoma receptor tyrosine-protein kinase OS=Xipho... [more]
sp|Q60553|ERBB2_MESAU5.512e-7330.85Receptor tyrosine-protein kinase erbB-2 OS=Mesocri... [more]
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BLAST of epidermal growth factor receptor 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1B1ACX90.000e+0100.00Receptor protein-tyrosine kinase OS=Schmidtea medi... [more]
F6KBQ30.000e+098.73Receptor protein-tyrosine kinase (Fragment) OS=Sch... [more]
A0A1B1ACY20.000e+038.01Receptor protein-tyrosine kinase OS=Schmidtea medi... [more]
A0A1B1ACY50.000e+037.24Receptor protein-tyrosine kinase OS=Schmidtea medi... [more]
A0A0X3PH980.000e+033.79Receptor protein-tyrosine kinase OS=Schistocephalu... [more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egfra3.313e-7533.00epidermal growth factor receptor-like [Source:NCBI... [more]
egfra4.711e-7533.00epidermal growth factor receptor-like [Source:NCBI... [more]
erbb24.366e-7429.58erb-b2 receptor tyrosine kinase 2 [Source:NCBI gen... [more]
erbb21.996e-7332.06erb-b2 receptor tyrosine kinase 2 [Source:NCBI gen... [more]
ENSAMXT00000016431.25.632e-7231.07epidermal growth factor receptor-like [Source:NCBI... [more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000003172.15.250e-7031.12pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 ge... [more]
EGFR4.755e-5127.07epidermal growth factor receptor [Source:HGNC Symb... [more]
ENSPMAT00000005822.15.535e-4846.15pep scaffold:Pmarinus_7.0:GL476959:64997:68848:-1 ... [more]
EPHB26.986e-4731.13EPH receptor B2 [Source:HGNC Symbol;Acc:HGNC:3393][more]
frk8.681e-4634.91fyn-related Src family tyrosine kinase [Source:ZFI... [more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
CDC157.969e-1923.51Protein kinase of the Mitotic Exit Network; locali... [more]
KIN13.119e-1727.27Serine/threonine protein kinase involved in regula... [more]
SNF16.218e-1528.93AMP-activated S/T protein kinase; forms a complex ... [more]
STE113.151e-1423.63Signal transducing MEK kinase; involved in pheromo... [more]
KIN23.433e-1424.04Serine/threonine protein kinase involved in regula... [more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO471953.493e-4937.85Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO409941.207e-4734.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO470943.594e-4735.69Predicted protein; Vascular endothelial growth fac... [more]
EDO337365.045e-4732.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO378863.647e-4635.13Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of epidermal growth factor receptor 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
egfra4.491e-7634.04epidermal growth factor receptor [Source:NCBI gene... [more]
ENSORLT00000004471.21.126e-7330.82melanoma receptor tyrosine-protein kinase [Source:... [more]
ENSORLT00000004469.21.365e-7332.58melanoma receptor tyrosine-protein kinase [Source:... [more]
egfra2.155e-7332.92epidermal growth factor receptor [Source:NCBI gene... [more]
erbb4b6.559e-7233.27erb-b2 receptor tyrosine kinase 4 [Source:NCBI gen... [more]
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BLAST of epidermal growth factor receptor 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000016935.10.000e+099.32SMESG000016935.1[more]
SMESG000005947.10.000e+037.16SMESG000005947.1[more]
SMESG000070834.10.000e+031.98SMESG000070834.1[more]
SMESG000070834.10.000e+032.23SMESG000070834.1[more]
SMESG000044603.11.512e-13230.17SMESG000044603.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30017456
GenBankAEE89451.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30017456 ID=SMED30017456|Name=epidermal growth factor receptor 3|organism=Schmidtea mediterranea sexual|type=transcript|length=4767bp
CGAATTCTTTATATCAGATGATTGAATTGTAGATATATCAGATCACAATC
TTAAGATTCAAATATGCATTTATTACTATTTGGAGTAGTAATTTTTATTT
CTAATATTTGTAATGGATCTAATTTTAATCCTGATTATCCGAATTTTCGA
ATTTGCGTCGTATCTGAGGCTCACGGTAGCTTTAAAACCCCAGCTGAAGC
ATACACATATTTGAAGTACACTCTTGGTCTGGGTCAGCGTTGCACTCACA
TTTACGGCAATCTTCCTATTAGTGATTTGAGCCGATTCAAAAACGGATCA
GATCCTGATTTGAGTTTCCTCGAATCGATTATTGAAATATCGGGATCACT
CTCGATTATCAACAATGACGTCAAACGGATCCCATTGACGAATTTGAAAG
TGATTCGTGGCGTAACACTGAGAAATGAACCCGATGCGTTAAATATCATT
CATAACCATTCAGAAAACGGGACGTTTTTGGAGGAAATAGATTTACGCAA
TTTACGAGCAATTATGAGTAAAAATGTGATTATCTCCCAGAATCCTGGAT
TGGAGTATTTGGAAAAGAATTTGGATTGGAGCCAAATTTTGGACGATCCA
ACGACCCAAAAGCTGAAAGTGTCTGAGTTTGTCCGGCCATCAAATGGCAC
AGCCAAGTGTCACACAGAATGTGAATACTGGACAAGGGAAGATGGCGTAA
GATCTCAATTTTGCTTCGGTCCTTCCAAAAACGAATGCCAAAAGCAAACC
AAGTGTGTGAAAAACAAAGATTTGAAGTGGTGCAAATTTACAAAGACTGG
CGAGATACCTTGCAGTCATGAATGCGCCGGTGGCTGTGATGGCAGAACCT
CAAAGGACTGCACGGTGTGCAATAAACTGGTCAAAGATTCTGATTGTGTC
AGTTCGTGCGCACCGCGGCCGAATCACATTTTCGGAATGGATTCAAAAGA
TAAACTCAGGTACACAGTTGGGGGTTTATGTACGAGCCAATGTCCAGCCT
CCTTATTGGATCAAAATAAAATATGTGTTTACGAGTGCGATTTTGATGCC
CATCAAAAAATCGGCAACCGCTGCATTGAGTGTCCGAATGGGAATTGCAA
TTCGTCAACTGCGGGATATAAGCTGTGTAATATTGCAACAATTGACAAAT
TCTATCCAAAAAATAACAGAAAATATTCATTGAACAAACAAACATTGATG
CAATTAACAAATTGCACTCTGATTCTCGGAGATTTGGATATCGATGATAT
ATCATTCAATAAAAATGGAGTTACTGTTCCAATGCTCTACCACCACTTAA
AAAATGTTCGAGAAATAATTGGTCTGTTTTCTTTGGTAACTTTCCAAACC
AAAATTTCCAATTTGACTTTTCTTTCAAACTTGGAAGAAATACGTTTGTC
TGTCAAATCCCACACAGTAGCGAGTGCAATGAACATTCACGGAAAGTATA
TCGAGTTCTTAGGATTGAAGAAGTTGAAAAAGGTTTATGGAAAAATCAGC
ATTGGTGGTACAAATGGAACTTGCTATTTAGATCGAATTCCTTGGGAAGA
AATTTCCCCTGACAACAGAGTGAAATTTTCATGCAATAAAACATGCGATC
CTTTATGTACCGGGCAATGTTGGGGACCTGGCAATGAGATGTGCTATTCT
TGCGCTTACTACAAAGCAGGAAATAGTTGCGTTAAACAATGCTCAGATTC
TCCTGGTTACTTTGCATCTCAAACAGAATTCAAGACAATCAAATGTCAAA
CTTGTCATCCCTTATGCAGACAAAATTGTACCGGACCGACACCAAAAAAC
TGCGGTGGTCAGTGCCGATATGCTATAGAAGAAAACACATGTGTAAAGAA
TTGTTCAATCGACTTCTTTCCGGTCGCGAACAACGTCAATGCACCAATCA
CTTGTCAACTGTGTCACAGTTCTTGTTTTGTGGATAAAACTCTAGTCGGA
ACTAATCATGCCTGCACTGGACCTTCCAATATTCTTGGAACTGGAGGATG
TTCAAAGTGTGAAAAATTAATAAAAACAAACAACAACCAATATTTATGCC
ACAAGGGATCATGTCCAAAAGGCTTTTATCAATCAGTTATAAACCAAAAC
ATAAGCCATTTGCATAAAAATATTGTGCACCAAAGCTCCTGTGAACCCTG
TCACTCAATGTGCCGAACCTGTTCAGGATCTACAAATGAAAAGCGTATGT
GCCATCAATGCAAAGGATATTTCCTCGATAACAAATGTGTTAAGGAATGT
GATAACATGAAAAATGTCACTATAAAGCTGGAAATCGGAGACGAGTGTCC
CCAGTGTCACAAAGAGTGCCGGAACGGATGCTTATTAGCCAATGACAGCA
CGGCTTGCACTCGGTGCCTCAATCACAAGCTGTTTGTGGACGATGACAAA
AATAAATTTTCATGCGTCACCCGGTGTCCACATGACAGGAATTTCACTGA
ATATCAAGACGGGGATTTTATCTGTCTGAAATTCGAGGAAACTATTAATA
GTAAACAAAGGAAGACCATCTTTATCATTTTGAGCGGTTGTTTCGGATTT
TTGGTGTTTATCATTGGATTTTGTGTTTTGTATTTTCGATGGCGAGCCAA
TCAGACCCGAATATTGGCGGAAATAAAAGCCCTTTACTCAAACTTCAAAG
AACCGGATATGAAGAACATGAAGGAGGACTACATTACAAGACCGCCAAAT
ATGAGAAGAATGCAAATGATACCCATCTCAGATCTTGTCTTTGATACTTC
ATCTAAACCCTTGGGGTCCGGAGCATTCGGGAAAGTTTATCGAGGATACT
GGAAAGTTCCTCGGCAGGATAATAAATATATTAACTTAGAAGTTGTCATT
AAAGTCATTCACAATTCCTCGAAAGGAAGCACAGATGAATTTCTTGAAGA
GGCCAAAATTATGGCGTCAGTATCCCATCGGCATTGTCTTCCGCTAATTG
GGGTTTGTTTGTCCCTAGAGAAGCCGTGCTTGGTGTCGACCTATGCACAG
CATGGAAGTTTGGATAAATACCTCCAGCAGAATAGCAAAAAGATTTCAAG
TCATTCCATGTTGAAATGGGCTAAACAAATTGCTGACGGCATGGCCTATT
TAAACAAAAGAGGAATAATACACAGAGACTTGGCGGCGAGAAACGTTTTG
GTTAATGACGATGATAATATACAAATAACTGATTTTGGTCTCGCGAGACT
TGTTGACGAAACCGATGATAGCATCGTTATAAAATCTGGAAAGGTTCCGA
TTAGATGGTTGGCGATTGAAACTTTATTAAGTGCGACCTATTCTCCAGCG
ACCGATGTTTGGGCGTATGGAGTAACACTCTGGGAGATATTTACTTATGC
CAAGCGGCCGTATGAAGAATTGGCTACTGGTGAAATCAAGTCATTTCTCC
AACAAGGAAATCGTCTCTGTCAGCCAGAAATTAGCACTCTCGAAGTGTAT
ATGGTTATGATTAAATGTTGGCTCGATGATCCCCACATGAGGCCGTCATT
CATGGAGTTGGTATCGACATTCGAGCAGTTCATCCAATCTCCCAAACGGT
TCCTTTACATGCCGCACGAATACGTCAATCAGCAATACCCGAAGGATGAA
GATCAGAGAGAAATGATTCAGTTGAATCAAATCTCCATAGATTCTGATTT
CAGGCCAATATCAATTAGAAATATCAAAAGCGATGAAACGAGCTGGGCGG
CGGCAACTCTACAAAACGACAGTGCATATCATTTGATCAACAACTCATAC
TCCAAAGAAAGCGATAAATCCTTTCTGCCGAAACGAAAGAAAGCCAAACG
AAACATTTCGCTAGAAAGAATTAAAAACTTTTCCAAGTTCGATTTGAACA
AAATTCTCTCACCGAAGTCTCACAGAGAATCAAAAAATTTCAATTACCAA
CATTCGAGTACTTATGACAGTAATAAAACAACCTGTACAAGCATTGATTC
AGGCAATCCGTTTTACACGCAACGCTCAAATGAATACGACACTCAACCAG
TCAATCCGCAAATTGCGAAACTCAGGAAAGAGATTAAGCATAACAACAGT
CTATATGATGGGTCTTCAAAGTCGGATAACACGTTCAAAATTCCAGAACG
AATTTTTATTGATAAAAGTCTAAAGGAAGAAACCGAACACTTATTGCAAA
GTCCTGAGAGTCGATCACCAAGTTTACCCCCTGTTGAAGTTCCCCACGTA
TTTCCTCGAACGAATCCCCAATTCGAATCCATCAAATCTTCAGTAGGAAA
TAGAATTGAAAATTCACCTGATAGTGGAAATAGTCATAATTTTGATATAG
ATGACTACCTAATACCGAGTCGCATATCATCTGCTGGATATTATAACCTT
ACTCCTTCGCCATCATCAAACGTGAAGCATTCCATGGAGCTTGAGGAAGT
GCCTTTGGCAGTTCTCAATAAGGAATATATTGATGATGATGGATATTTGG
AACCGAAAAAATTTGATCGATAAATAATTTTGGTGTATTTATTGATATTT
GAAATAAGTCATTGATATTTGCAATTTTTATTGATTGAATTTTTTGATAA
ATTTTATTGTCAGATTTCCTGGTGCTGATAGTCCGAGTCTCTCCATAAAC
CTTTCACCCTCTTCTTTCCCATTCACTCGCACTCCCTCTCAACCCCGCTA
ACCCCTTCACCCTTTCCTTCACTTCCGAATTTCAAACATTTATATCGATT
TATTGATCATTCCAGCTCTGTAAATATCCATAATTCATTGGAAATTTGTG
ATATTTTTATACCTGAT
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protein sequence of SMED30017456-orf-1

>SMED30017456-orf-1 ID=SMED30017456-orf-1|Name=SMED30017456-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1470bp
MHLLLFGVVIFISNICNGSNFNPDYPNFRICVVSEAHGSFKTPAEAYTYL
KYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIIN
NDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRNLRAI
MSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCH
TECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNKDLKWCKFTKTGEIPC
SHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFGMDSKDKLRY
TVGGLCTSQCPASLLDQNKICVYECDFDAHQKIGNRCIECPNGNCNSSTA
GYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTLILGDLDIDDISFNK
NGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSH
TVASAMNIHGKYIEFLGLKKLKKVYGKISIGGTNGTCYLDRIPWEEISPD
NRVKFSCNKTCDPLCTGQCWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYF
ASQTEFKTIKCQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSID
FFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCE
KLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMC
RTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHK
ECRNGCLLANDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDG
DFICLKFEETINSKQRKTIFIILSGCFGFLVFIIGFCVLYFRWRANQTRI
LAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPL
GSGAFGKVYRGYWKVPRQDNKYINLEVVIKVIHNSSKGSTDEFLEEAKIM
ASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSML
KWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDET
DDSIVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPY
EELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELV
STFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRPIS
IRNIKSDETSWAAATLQNDSAYHLINNSYSKESDKSFLPKRKKAKRNISL
ERIKNFSKFDLNKILSPKSHRESKNFNYQHSSTYDSNKTTCTSIDSGNPF
YTQRSNEYDTQPVNPQIAKLRKEIKHNNSLYDGSSKSDNTFKIPERIFID
KSLKEETEHLLQSPESRSPSLPPVEVPHVFPRTNPQFESIKSSVGNRIEN
SPDSGNSHNFDIDDYLIPSRISSAGYYNLTPSPSSNVKHSMELEEVPLAV
LNKEYIDDDGYLEPKKFDR*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000034epidermis
PLANA:0000044cephalic ganglia
PLANA:0000099neuron
PLANA:0000418head
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
PLANA:0002142parenchyma
Vocabulary: INTERPRO
TermDefinition
IPR036941Rcpt_L-dom_sf
IPR000299FERM_domain
IPR001245Ser-Thr/Tyr_kinase_cat_dom
IPR006212Furin_repeat
IPR020635Tyr_kinase_cat_dom
IPR032778GF_recep_IV
IPR000494Rcpt_L-dom
IPR006211Furin-like_Cys-rich_dom
IPR017441Protein_kinase_ATP_BS
IPR008266Tyr_kinase_AS
IPR000719Prot_kinase_dom
IPR032675LRR_dom_sf
IPR009030Growth_fac_rcpt_cys_sf
IPR011009Kinase-like_dom_sf
Vocabulary: cellular component
TermDefinition
GO:0005856cytoskeleton
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0004713protein tyrosine kinase activity
GO:0005524ATP binding
GO:0004714transmembrane receptor protein tyrosine kinase activity
GO:0000166nucleotide binding
GO:0016301kinase activity
GO:0016740transferase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016310phosphorylation
GO:0018108peptidyl-tyrosine phosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPRINTSPR00109TYRKINASEcoord: 1080..1102
score: 49.39
coord: 1124..1146
score: 38.8
coord: 1012..1030
score: 62.69
coord: 1061..1071
score: 46.7
coord: 975..988
score: 34.49
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPFAMPF07714Pkinase_Tyrcoord: 897..1152
e-value: 6.2E-82
score: 274.8
IPR020635Tyrosine-protein kinase, catalytic domainSMARTSM00219tyrkin_6coord: 894..1153
e-value: 6.5E-112
score: 387.8
IPR006212Furin-like repeatSMARTSM00261furin_3coord: 611..673
e-value: 6.9
score: 12.4
coord: 558..603
e-value: 0.0055
score: 25.9
coord: 228..290
e-value: 0.096
score: 21.8
coord: 742..794
e-value: 0.0012
score: 28.1
coord: 504..551
e-value: 3.9E-5
score: 33.1
coord: 690..735
e-value: 4.4E-5
score: 32.9
IPR006212Furin-like repeatCDDcd00064FUcoord: 249..284
e-value: 0.00940547
score: 33.6464
IPR006212Furin-like repeatCDDcd00064FUcoord: 695..729
e-value: 2.08906E-4
score: 38.2688
IPR006212Furin-like repeatCDDcd00064FUcoord: 511..557
e-value: 5.64116E-5
score: 39.8096
NoneNo IPR availableGENE3DG3DSA:2.10.220.10coord: 696..819
e-value: 1.0E-10
score: 43.5
NoneNo IPR availableGENE3DG3DSA:2.10.220.10coord: 577..641
e-value: 9.6E-8
score: 34.0
coord: 524..576
e-value: 1.9E-14
score: 55.5
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 842..975
e-value: 5.5E-23
score: 83.2
NoneNo IPR availableGENE3DG3DSA:2.10.220.10coord: 225..345
e-value: 2.5E-14
score: 55.2
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 979..1174
e-value: 1.1E-53
score: 183.4
NoneNo IPR availablePANTHERPTHR24416:SF95EPIDERMAL GROWTH FACTOR RECEPTORcoord: 487..1281
coord: 51..493
NoneNo IPR availablePANTHERPTHR24416TYROSINE-PROTEIN KINASE RECEPTORcoord: 487..1281
coord: 51..493
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..18
score: 0.765
NoneNo IPR availableSUPERFAMILYSSF52058L domain-likecoord: 375..523
NoneNo IPR availableSUPERFAMILYSSF52058L domain-likecoord: 57..219
NoneNo IPR availableTMHMMTMhelixcoord: 819..841
IPR000494Receptor L-domainPFAMPF01030Recep_L_domaincoord: 383..497
e-value: 7.4E-10
score: 38.9
coord: 60..175
e-value: 5.8E-19
score: 68.3
IPR032778Growth factor receptor domain 4PFAMPF14843GF_recep_IVcoord: 510..621
e-value: 5.0E-14
score: 52.2
IPR036941Receptor L-domain superfamilyGENE3DG3DSA:3.80.20.20coord: 29..224
e-value: 7.7E-38
score: 132.1
IPR036941Receptor L-domain superfamilyGENE3DG3DSA:3.80.20.20coord: 352..523
e-value: 8.3E-19
score: 69.9
IPR006211Furin-like cysteine-rich domainPFAMPF00757Furin-likecoord: 203..347
e-value: 1.2E-8
score: 35.0
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 900..930
IPR008266Tyrosine-protein kinase, active sitePROSITEPS00109PROTEIN_KINASE_TYRcoord: 1018..1030
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 894..1157
score: 36.909
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 898..1176
IPR009030Growth factor receptor cysteine-rich domain superfamilySUPERFAMILYSSF57184Growth factor receptor domaincoord: 511..621
IPR009030Growth factor receptor cysteine-rich domain superfamilySUPERFAMILYSSF57184Growth factor receptor domaincoord: 695..803