Serine/threonine kinase

Overview


Name	Serine/threonine kinase
Smed ID	SMED30017337
Length (bp)	1693

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30017337

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30017337	h1SMcG0019681	Contig764	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30017337	h1SMcG0018797	Contig764	GPL15192	PMID:23079596 Forsthoefel et al., 2012
Smed sexual biotype	SMED30017337	h1SMcG0019681	Contig764	GPL15192	PMID:29674431 Fincher et al., 2018
nervous system	SMED30017337	h1SMcG0019681	dd_Smed_v4_1212_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30017337	h1SMcG0019681	dd_Smed_v4_1212_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30017337	h1SMcG0019681	dd_Smed_v4_1212_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30017337	h1SMcG0019681	dd_Smed_v4_1212_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30017337	h1SMcG0019681	dd_Smed_v4_1212_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30017337	h1SMcG0019681	dd_Smed_v4_1212_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30017337	h1SMcG0018797	Contig764	GPL15192	PMID:29674431 Fincher et al., 2018
epidermis	SMED30017337	h1SMcG0019681	dd_Smed_v4_1212_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Serine/threonine kinase vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 108.612 bits (270), Expect = 2.883e-24
Identity = 68/183 (37.16%), Postives = 99/183 (54.10%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     R I    + RP+A EL
Sbjct:  435 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEEL 612

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 108.612 bits (270), Expect = 2.999e-24
Identity = 68/183 (37.16%), Postives = 99/183 (54.10%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     R I    + RP+A EL
Sbjct:  439 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEEL 616

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 108.612 bits (270), Expect = 3.122e-24
Identity = 68/183 (37.16%), Postives = 99/183 (54.10%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     R I    + RP+A EL
Sbjct:  470 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEEL 647

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 108.612 bits (270), Expect = 3.122e-24
Identity = 68/183 (37.16%), Postives = 99/183 (54.10%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     R I    + RP+A EL
Sbjct:  470 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEEL 647

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 108.612 bits (270), Expect = 3.380e-24
Identity = 68/183 (37.16%), Postives = 99/183 (54.10%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     R I    + RP+A EL
Sbjct:  466 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEEL 643

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 97.0561 bits (240), Expect = 8.683e-21
Identity = 76/287 (26.48%), Postives = 141/287 (49.13%), Query Frame = 3

Query:  726 PLDRECKIYCVEMSNKLELTII----SKISTGKFADIYLGKINSFNR--DCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGS-LKSRLSASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGIT--GSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISG------YDAIIARCIRPIQKHRPNAWEL 1541
            P +R   +  +E ++KL+  +I     +I  G F ++Y G  N   R    +++   Q   +  + +  + +V+++    Y T     +    + +  KL I+ EY+ GGS L    S  L  + I    R+ILKGL++LH E+ IHR+I   +VL+  +G+ K+ +F ++  L    T+ +   IT  GS        +APE++    Y +KAD+WS G   I++ + + P+ D++ ++   LI +N      P++ G      +   +  C+    ++RP+A  L
Sbjct:  162 PAERRKVVKPIEDNSKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQ-EIQVLSQCDSQYVT-----KYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQL----TETVKKRITFVGSPF-----WMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKN----PPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTL 429

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: F26E4.5 (Tyrosine-protein kinase [Source:UniProtKB/TrEMBL;Acc:O01325])

HSP 1 Score: 95.5153 bits (236), Expect = 1.050e-20
Identity = 81/307 (26.38%), Postives = 137/307 (44.63%), Query Frame = 3

Query:  627 LKEFILNENKQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVEMSNKLELTIISKISTGKFADIYLG--KINSFNRDCEVLKYRQNISDFNNFKNSKYEVITRLK----LPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLSA---SLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEP---IISGYDAIIARCIRPI 1511
            LKEF              T  S      +L S+ +  E ++Y        ++ +  K+  G+F +++ G   +  F  D EV      +      K +  E IT L+    +        V L  + T+ E + IV E  +GG LKSR+      L      KYC+QI KG+++L  +++IHR++   +VL+D + N K+++F LS F        L+      KV      +APE LL   Y  K+DVWSFG ++ ++ S + PY DV  ++       +  +  +P   + +    ++  C  P+
Sbjct:  150 LKEFCFENISDLVRYHHQTRASVYKSGIKLFSWVVREEWQLY------HEQINLGKKLGNGEFGEVFQGVLSVGIFTNDVEVA-----VKTMKGSKVTADERITFLREANLMLKLNHKYVVRLYGVATQQEPIMIVMELCSGGCLKSRIEKKDEQLSDVLKRKYCKQIAKGMRYLEKKQVIHRDLAARNVLLDKSDNCKISDFGLSLFGKLHKEQKLM------KV--PIRWLAPETLLKGIYSSKSDVWSFGVVMFEVFSGEYPYADVKVLKELRRKVAHENLRLKPPSDMPTDDAKVMEMCFEPV 437

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 94.3597 bits (233), Expect = 4.902e-20
Identity = 69/272 (25.37%), Postives = 131/272 (48.16%), Query Frame = 3

Query:  744 KIYCVEMSNKLELTIISKISTGKFADIYLGKINSFNR--DCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGS-LKSRLSASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISG------YDAIIARCIRPIQKHRPNA 1532
            +IY  ++  ++  T   +I  G F ++Y G  N   R    +++   Q   +  + +  + +V+++    Y T     +    + +  KL I+ EY+ GGS L    S  L  + I    R+ILKGL++LH E+ IHR+I   +VL+  +G+ K+ +F ++  L       +     GS        +APE++    Y +KAD+WS G   I++ + + P+ D++ ++   LI +N      P++ G      +   +  C+    ++RP+A
Sbjct:   22 RIYIQKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQ-EIQVLSQCDSQYVT-----KYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRIT--FVGSPF-----WMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKN----PPPVLQGSQWSKPFKEFVEMCLNKDPENRPSA 276

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 91.2781 bits (225), Expect = 4.404e-19
Identity = 67/258 (25.97%), Postives = 124/258 (48.06%), Query Frame = 3

Query:  795 KISTGKFADIYLGKINSFNR--DCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGS-LKSRLSASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISG------YDAIIARCIRPIQKHRPNAWEL 1541
            +I  G F ++Y G  N   R    +++   Q   +  + +  + +V+++    Y T     +    + +  KL I+ EY+ GGS L    S  L  + I    R+ILKGL++LH E+ IHR+I   +VL+  +G+ K+ +F ++  L       +     GS        +APE++    Y +KAD+WS G   I++ + + P+ D++ ++   LI +N      P++ G      +   +  C+    ++RP+A  L
Sbjct:   24 RIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQ-EIQVLSQCDSQYVT-----KYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRIT--FVGSPF-----WMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKN----PPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTL 264

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 90.8929 bits (224), Expect = 5.486e-19
Identity = 70/271 (25.83%), Postives = 130/271 (47.97%), Query Frame = 3

Query:  768 NKLELTII----SKISTGKFADIYLGKINSFNR--DCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGS-LKSRLSASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISG------YDAIIARCIRPIQKHRPNAWEL 1541
            +KL+  +I     +I  G F ++Y G  N   R    +++   Q   +  + +  + +V+++    Y T     +    + +  KL I+ EY+ GGS L    S  L  + I    R+ILKGL++LH E+ IHR+I   +VL+  +G+ K+ +F ++  L       +     GS        +APE++    Y +KAD+WS G   I++ + + P+ D++ ++   LI +N      P++ G      +   +  C+    ++RP+A  L
Sbjct:    6 SKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQ-EIQVLSQCDSQYVT-----KYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRIT--FVGSPF-----WMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKN----PPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTL 259

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334539)

HSP 1 Score: 94.3597 bits (233), Expect = 6.830e-20
Identity = 52/161 (32.30%), Postives = 92/161 (57.14%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNF-YLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAEN 1442
             V  ++ Y  +E+L +V EY+ GGSL   ++ + +   +I   CR++L+ L+FLH  ++IHR+I  +++L+  +G+ KLT+F + ++     +    + G            +APEV+  + YG K D+WS G M I++V  + PY + N ++A  LIA N
Sbjct:  487 VVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTP--------YWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATN 639

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081714)

HSP 1 Score: 94.3597 bits (233), Expect = 6.830e-20
Identity = 52/161 (32.30%), Postives = 92/161 (57.14%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNF-YLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAEN 1442
             V  ++ Y  +E+L +V EY+ GGSL   ++ + +   +I   CR++L+ L+FLH  ++IHR+I  +++L+  +G+ KLT+F + ++     +    + G            +APEV+  + YG K D+WS G M I++V  + PY + N ++A  LIA N
Sbjct:  487 VVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTP--------YWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATN 639

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081716)

HSP 1 Score: 94.3597 bits (233), Expect = 6.830e-20
Identity = 52/161 (32.30%), Postives = 92/161 (57.14%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNF-YLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAEN 1442
             V  ++ Y  +E+L +V EY+ GGSL   ++ + +   +I   CR++L+ L+FLH  ++IHR+I  +++L+  +G+ KLT+F + ++     +    + G            +APEV+  + YG K D+WS G M I++V  + PY + N ++A  LIA N
Sbjct:  487 VVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTP--------YWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATN 639

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081715)

HSP 1 Score: 94.3597 bits (233), Expect = 6.830e-20
Identity = 52/161 (32.30%), Postives = 92/161 (57.14%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNF-YLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAEN 1442
             V  ++ Y  +E+L +V EY+ GGSL   ++ + +   +I   CR++L+ L+FLH  ++IHR+I  +++L+  +G+ KLT+F + ++     +    + G            +APEV+  + YG K D+WS G M I++V  + PY + N ++A  LIA N
Sbjct:  487 VVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTP--------YWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATN 639

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334544)

HSP 1 Score: 94.3597 bits (233), Expect = 6.830e-20
Identity = 52/161 (32.30%), Postives = 92/161 (57.14%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNF-YLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAEN 1442
             V  ++ Y  +E+L +V EY+ GGSL   ++ + +   +I   CR++L+ L+FLH  ++IHR+I  +++L+  +G+ KLT+F + ++     +    + G            +APEV+  + YG K D+WS G M I++V  + PY + N ++A  LIA N
Sbjct:  487 VVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTP--------YWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATN 639

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 115.161 bits (287), Expect = 1.501e-26
Identity = 73/188 (38.83%), Postives = 104/188 (55.32%), Query Frame = 3

Query:  993 ENEK-LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
             NEK L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     RCI    K+RP+A EL
Sbjct:  434 HNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPSHISEHTRDFLRCIFVEAKYRPSAEEL 616

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 115.161 bits (287), Expect = 1.607e-26
Identity = 73/188 (38.83%), Postives = 104/188 (55.32%), Query Frame = 3

Query:  993 ENEK-LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
             NEK L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     RCI    K+RP+A EL
Sbjct:  428 HNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPSHISEHTRDFLRCIFVEAKYRPSAEEL 610

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 114.775 bits (286), Expect = 1.995e-26
Identity = 73/188 (38.83%), Postives = 104/188 (55.32%), Query Frame = 3

Query:  993 ENEK-LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
             NEK L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     RCI    K+RP+A EL
Sbjct:  416 HNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPSHISEHTRDFLRCIFVEAKYRPSAEEL 598

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 101.293 bits (251), Expect = 4.713e-22
Identity = 63/188 (33.51%), Postives = 100/188 (53.19%), Query Frame = 3

Query:  990 TENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
            T  + L I  EYM GGS+K +L +   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  S+ L   C +   +  +TG+        ++PEV+ GE YG KAD+WS G  ++++++ + P+ +  ++ A   IA   T     P +S +     + I    K RP A +L
Sbjct:  426 THEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPY-----WMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPTLPPHVSDHCRDFLKRIFVETKQRPAAEDL 608

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 101.293 bits (251), Expect = 4.857e-22
Identity = 63/188 (33.51%), Postives = 100/188 (53.19%), Query Frame = 3

Query:  990 TENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
            T  + L I  EYM GGS+K +L +   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  S+ L   C +   +  +TG+        ++PEV+ GE YG KAD+WS G  ++++++ + P+ +  ++ A   IA   T     P +S +     + I    K RP A +L
Sbjct:  434 THEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPY-----WMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPTLPPHVSDHCRDFLKRIFVETKQRPAAEDL 616

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 106.301 bits (264), Expect = 1.819e-23
Identity = 57/156 (36.54%), Postives = 90/156 (57.69%), Query Frame = 3

Query:  990 TENEKLCIVTEYMTGGSLKSRLSASLGVAEI--NKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT 1448
            ++ + L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D +GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KAD+WS G  ++++++ K P+ +  ++ A   IA   T
Sbjct:  439 SQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPY-----WMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPT 589

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 105.531 bits (262), Expect = 2.492e-23
Identity = 66/184 (35.87%), Postives = 99/184 (53.80%), Query Frame = 3

Query: 1002 KLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEP-IISGYDAIIARCIRPIQKHRPNAWEL 1541
            KL I  EYM GGS+K +L A   + E    +Y RQIL+G+ +LHG  I+HR+I   ++L D  GN KL +F  SK +   C +   +  +TG+        ++PEV+ GE YG KADVWS    ++++++ K P+ +  ++ A   IA   T    P  +S       + I   +K RP A EL
Sbjct:  430 KLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSGTGIKSVTGTPY-----WMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWSEYEAMAAIFKIATQPTKPRLPDTVSDACRDFMKQIFVEEKRRPTAEEL 608

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 105.531 bits (262), Expect = 2.711e-23
Identity = 57/156 (36.54%), Postives = 90/156 (57.69%), Query Frame = 3

Query:  990 TENEKLCIVTEYMTGGSLKSRLSASLGVAEI--NKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT 1448
            ++ + L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D +GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KAD+WS G  ++++++ K P+ +  ++ A   IA   T
Sbjct:  411 SQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPY-----WMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPT 561

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 105.531 bits (262), Expect = 2.731e-23
Identity = 66/184 (35.87%), Postives = 99/184 (53.80%), Query Frame = 3

Query: 1002 KLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEP-IISGYDAIIARCIRPIQKHRPNAWEL 1541
            KL I  EYM GGS+K +L A   + E    +Y RQIL+G+ +LHG  I+HR+I   ++L D  GN KL +F  SK +   C +   +  +TG+        ++PEV+ GE YG KADVWS    ++++++ K P+ +  ++ A   IA   T    P  +S       + I   +K RP A EL
Sbjct:  437 KLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSGTGIKSVTGTPY-----WMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWSEYEAMAAIFKIATQPTKPRLPDTVSDACRDFMKQIFVEEKRRPTAEEL 615

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 103.605 bits (257), Expect = 1.082e-22
Identity = 57/151 (37.75%), Postives = 86/151 (56.95%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT 1448
            L I  EYM GGS+K +L A   + E    +Y RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T
Sbjct:  442 LTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPT 587

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874])

HSP 1 Score: 108.227 bits (269), Expect = 3.000e-24
Identity = 68/183 (37.16%), Postives = 99/183 (54.10%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     R I    + RP+A EL
Sbjct:  439 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEEL 616

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873])

HSP 1 Score: 105.916 bits (263), Expect = 1.568e-23
Identity = 66/187 (35.29%), Postives = 100/187 (53.48%), Query Frame = 3

Query:  993 ENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
            + + L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KAD+WS    ++++++ K P+ +  ++ A   IA   T     P +S Y     + I    K RP+A EL
Sbjct:  429 QEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPY-----WMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEEL 610

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Pak2 (p21 (RAC1) activated kinase 2 [Source:MGI Symbol;Acc:MGI:1339984])

HSP 1 Score: 97.0561 bits (240), Expect = 8.815e-21
Identity = 57/163 (34.97%), Postives = 92/163 (56.44%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDM-LLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT 1448
             V  ++ Y   ++L +V EY+ GGSL   ++ + +  A+I   CR+ L+ L+FLH  ++IHR+I  ++VL+   G+ KLT+F    F    T +    S + G+        +APEV+  + YG K D+WS G M I++V  + PY + N ++A  LIA N T
Sbjct:  306 IVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDF---GFCAQITPEQSKRSTMVGTPY-----WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 460

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Stk25 (serine/threonine kinase 25 (yeast) [Source:MGI Symbol;Acc:MGI:1891699])

HSP 1 Score: 93.9745 bits (232), Expect = 3.858e-20
Identity = 73/262 (27.86%), Postives = 124/262 (47.33%), Query Frame = 3

Query:  780 LTIISKISTGKFADIYLGKINSFNRDCEVLKYRQNISDFNNFKNSKYE--VITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLS-ASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDA-----IIARCIRPIQKHRPNAWEL 1541
             T + +I  G F ++Y G I++  ++   +K        +  ++ + E  V+++   PY T          Y ++ KL I+ EY+ GGS    L    L    I    R+ILKGL +LH E+ IHR+I   +VL+   G+ KL +F ++  L +  T +  +   G+        +APEV+    Y FKAD+WS G   I++   + P  D++ ++   LI +N      P + G+ +      +  C+    + RP A EL
Sbjct:   20 FTKLDRIGKGSFGEVYKG-IDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT-----RYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD--TQIKRNTFVGTPF-----WMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNP----PTLEGHHSKPFKEFVEACLNKDPRFRPTAKEL 264

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Pak1 (p21 (RAC1) activated kinase 1 [Source:MGI Symbol;Acc:MGI:1339975])

HSP 1 Score: 93.9745 bits (232), Expect = 7.736e-20
Identity = 54/163 (33.13%), Postives = 92/163 (56.44%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDM-LLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT 1448
             V  ++ Y   ++L +V EY+ GGSL   ++ + +   +I   CR+ L+ L+FLH  ++IHR+I  +++L+  +G+ KLT+F    F    T +    S + G+        +APEV+  + YG K D+WS G M I+++  + PY + N ++A  LIA N T
Sbjct:  326 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDF---GFCAQITPEQSKRSTMVGTPY-----WMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 480

[Close]

BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q99759|M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2)

HSP 1 Score: 108.612 bits (270), Expect = 1.440e-23
Identity = 68/183 (37.16%), Postives = 99/183 (54.10%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     R I    + RP+A EL
Sbjct:  439 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEEL 616

[Close]

BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q61084|M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus OX=10090 GN=Map3k3 PE=1 SV=1)

HSP 1 Score: 108.227 bits (269), Expect = 2.099e-23
Identity = 68/183 (37.16%), Postives = 99/183 (54.10%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P  IS +     R I    + RP+A EL
Sbjct:  439 LTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEEL 616

[Close]

BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q9Y2U5|M3K2_HUMAN (Mitogen-activated protein kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP3K2 PE=1 SV=2)

HSP 1 Score: 105.916 bits (263), Expect = 9.507e-23
Identity = 66/187 (35.29%), Postives = 100/187 (53.48%), Query Frame = 3

Query:  993 ENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
            + + L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KAD+WS    ++++++ K P+ +  ++ A   IA   T     P +S Y     + I    K RP+A EL
Sbjct:  429 QEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPY-----WMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADEL 610

[Close]

BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q6BNF3|STE20_DEBHA (Serine/threonine-protein kinase STE20 OS=Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) OX=284592 GN=STE20 PE=3 SV=2)

HSP 1 Score: 102.449 bits (254), Expect = 2.341e-21
Identity = 68/199 (34.17%), Postives = 109/199 (54.77%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTI-LYEPIISGYD--AIIARCIRPIQKHRPNAWELHND 1550
             V  I+ Y     L +V EYM GGSL   ++ S +   +I   CR+ LKGL+FLH + +IHR+I  +++L++ +GN K+T+F     +     ++  + + G+        +APEV+  + YG K DVWS G M+I+++  + PY +   ++A  LIA N T  L EP    YD    ++ C++     R NA +L ND
Sbjct:  859 IVNFIDSYLLRGDLWVVMEYMEGGSLTEIVTHSVMTEGQIGAVCRETLKGLRFLHSKGVIHRDIKSDNILLNIDGNIKMTDFGFCAQINEI--NLKRTTMVGTPY-----WMAPEVVSRKEYGPKVDVWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPEALSYDIRKFLSWCLQVDFNKRGNADQLLND 1050

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BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q61083|M3K2_MOUSE (Mitogen-activated protein kinase kinase kinase 2 OS=Mus musculus OX=10090 GN=Map3k2 PE=1 SV=2)

HSP 1 Score: 99.7525 bits (247), Expect = 1.174e-20
Identity = 64/187 (34.22%), Postives = 98/187 (52.41%), Query Frame = 3

Query:  993 ENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
            + + L I  E   GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KAD+WS    ++++++ K P+ +  ++ A   IA   T     P +S Y     + I    K RP+A EL
Sbjct:  429 QEKTLSIFMELSPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPY-----WMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEEL 610

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BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A3Q2CUL5 (Mitogen-activated protein kinase kinase kinase 3 OS=Cyprinodon variegatus OX=28743 PE=4 SV=1)

HSP 1 Score: 119.398 bits (298), Expect = 1.212e-24
Identity = 72/185 (38.92%), Postives = 102/185 (55.14%), Query Frame = 3

Query:  999 EKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
            +KL I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T  L  P  S       RCI    KHRP+A EL
Sbjct:  428 KKLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSEGNVKLGDFGASKRLQTICMSGTGIRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPLLPPRASDQARDFIRCIFVEAKHRPSAEEL 607

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BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A3Q2CUJ6 (Mitogen-activated protein kinase kinase kinase 3 OS=Cyprinodon variegatus OX=28743 PE=4 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 1.683e-24
Identity = 72/185 (38.92%), Postives = 102/185 (55.14%), Query Frame = 3

Query:  999 EKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
            +KL I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T  L  P  S       RCI    KHRP+A EL
Sbjct:  428 KKLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSEGNVKLGDFGASKRLQTICMSGTGIRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPLLPPRASDQARDFIRCIFVEAKHRPSAEEL 607

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BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A087Y7U3 (Mitogen-activated protein kinase kinase kinase 3 OS=Poecilia formosa OX=48698 PE=4 SV=2)

HSP 1 Score: 119.013 bits (297), Expect = 1.912e-24
Identity = 74/188 (39.36%), Postives = 103/188 (54.79%), Query Frame = 3

Query:  993 ENEK-LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
             NEK L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T  L  P  S       RCI    KHRP+A EL
Sbjct:  425 HNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPLLPPRASDQARDFIRCIFVEAKHRPSAEEL 607

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BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A3B3YHL3 (Mitogen-activated protein kinase kinase kinase 3 OS=Poecilia mexicana OX=48701 PE=4 SV=1)

HSP 1 Score: 118.627 bits (296), Expect = 2.232e-24
Identity = 74/188 (39.36%), Postives = 103/188 (54.79%), Query Frame = 3

Query:  993 ENEK-LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
             NEK L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T  L  P  S       RCI    KHRP+A EL
Sbjct:  425 HNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPLLPPRASDQARDFIRCIFVEAKHRPSAEEL 607

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BLAST of Serine/threonine kinase vs. TrEMBL
Match: M4A106 (Mitogen-activated protein kinase kinase kinase 3 OS=Xiphophorus maculatus OX=8083 PE=4 SV=1)

HSP 1 Score: 118.627 bits (296), Expect = 2.273e-24
Identity = 74/188 (39.36%), Postives = 103/188 (54.79%), Query Frame = 3

Query:  993 ENEK-LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT-ILYEPIISGYDAIIARCIRPIQKHRPNAWEL 1541
             NEK L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T  L  P  S       RCI    KHRP+A EL
Sbjct:  425 HNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTQKPPWAEFEAMAAIFKIATQPTNPLLPPRASDQARDFIRCIFVEAKHRPSAEEL 607

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BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 112.849 bits (281), Expect = 6.050e-26
Identity = 73/191 (38.22%), Postives = 106/191 (55.50%), Query Frame = 3

Query:  993 ENEK-LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDAIIAR-CIRPI---QKHRPNAWEL 1541
             NEK L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ G+ YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    PI+  + +   R  IR I    KHRP+A EL
Sbjct:  428 HNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPY-----WMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPT---NPILPSHTSEQTRDFIRRIFVEAKHRPSAEEL 610

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Query:  993 ENEK-LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDAIIAR-CIRPI---QKHRPNAWEL 1541
             NEK L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ G+ YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    PI+  + +   R  IR I    KHRP+A EL
Sbjct:  428 HNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPY-----WMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPT---NPILPSHTSEQTRDFIRRIFVEAKHRPSAEEL 610

[Close]

Query:  993 ENEK-LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDAIIAR-CIRPI---QKHRPNAWEL 1541
             NEK L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ G+ YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    PI+  + +   R  IR I    KHRP+A EL
Sbjct:  428 HNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPY-----WMSPEVISGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPT---NPILPSHTSEQTRDFIRRIFVEAKHRPSAEEL 610

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BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:103026704])

HSP 1 Score: 102.834 bits (255), Expect = 1.152e-22
Identity = 65/188 (34.57%), Postives = 100/188 (53.19%), Query Frame = 3

Query:  990 TENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            T    L I  EYM GGS+K +L +   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  S+ L   C +   +  +TG+        ++PEV+ GE YG KAD+WS G  ++++++L+ P+ +  ++ A   IA   T    P  +S +     + I    K RP A EL
Sbjct:  431 THERTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPY-----WMSPEVISGEGYGRKADIWSVGCTVVEMLTLRPPWAEFEAMAAIFKIATQPTNPALPAHVSDHCRDFLKRIFVETKQRPAAEEL 613

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BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: stk25a (serine/threonine-protein kinase 25 [Source:NCBI gene;Acc:103021644])

HSP 1 Score: 99.7525 bits (247), Expect = 4.246e-22
Identity = 79/257 (30.74%), Postives = 125/257 (48.64%), Query Frame = 3

Query:  780 LTIISKISTGKFADIYLGKINSFNRDCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFV-ELINMYTENEKLCIVTEYMTGGSLKSRLS-ASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIIS-GYDAIIARCIRPIQKHRPNAWEL 1541
             T + +I  G F ++Y G IN  NR  EV+  +  I D    ++   ++   + +     SPFV +    Y ++ KL I+ EY+ GGS    L    L  A I    R+ILKGL +LH E+ IHR+I   +VL+  +G  KL +F ++  L +  T +  +   G+        +APEV+    Y FKAD+WS G   I++   + P  D++ ++   LI +N     E   S  +   +  C+    + RP A EL
Sbjct:   20 FTKLERIGKGSFGEVYKG-IN--NRTKEVVAIK--IIDLEEAEDEIEDIQQEITVLSQCDSPFVTKYFGSYLKSTKLWIIMEYLGGGSALDMLKPGPLEEAYIATILREILKGLDYLHSERKIHRDIKAANVLLSEHGEVKLADFGVAGQLTD--TQIKRNTFVGTPF-----WMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLEGSYSKAFKDFVEACLNKDPRFRPTAKEL 264

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BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 108.997 bits (271), Expect = 2.262e-25
Identity = 68/187 (36.36%), Postives = 103/187 (55.08%), Query Frame = 3

Query:  993 ENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            + + L I  EYM GGS+K +L A   + E    KY RQIL+G+ FLHG  I+HR+I   ++L D  GN KL +F  SK L   C+    +  +TG+        ++PEV+ GE YG KAD+WS G  ++++++ K P+ +  ++ A   IA   T    P+  S +   + R I    K RP+A +L
Sbjct:  432 QQKTLSIFMEYMPGGSIKDQLRAYGALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGTAMRSVTGTPY-----WMSPEVINGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTDPRLPLHASEHARDLLRRIFVEAKLRPSAEDL 613

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BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008193.1 (pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-1 gene:ENSPMAG00000007385.1 transcript:ENSPMAT00000008193.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.1965 bits (217), Expect = 4.253e-19
Identity = 54/180 (30.00%), Postives = 92/180 (51.11%), Query Frame = 3

Query: 1008 CIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIIS----GYDAIIARCIRPIQKHRPN 1529
            CI+ EY   G L   L A   ++   +  + R I +G+ +LH  KIIHR++   +VLI  +   K+++F  SK +   +T M  +G            +APEV+  EP   K D+WSFG +L ++++ + PY DV+S      +  N   L+ PI +    G+  ++ +C     ++RP+
Sbjct:   76 CIIMEYCAQGQLYEVLRAGRRISPELLVGWTRGIARGMSYLHLHKIIHRDLKSPNVLITHDDEVKISDFGTSKEMREKSTRMSFAGTV--------AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYRDVDSSAIIWGVGSNS--LHLPIPASCPEGFKILLTQCWNSKPRNRPS 245

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BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002088.1 (pep scaffold:Pmarinus_7.0:GL478600:446:35095:-1 gene:ENSPMAG00000001892.1 transcript:ENSPMAT00000002088.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 85.8853 bits (211), Expect = 6.135e-19
Identity = 53/178 (29.78%), Postives = 88/178 (49.44%), Query Frame = 3

Query: 1008 CIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI--ISGYDAIIARCIRPIQKHRPN 1529
            CI+ EY   G L   L A   +    + ++   I  G+ +LH  KIIHR++   +VLI  +   K+++F  SK L + +T M  +G            +APEV+  EP   K D+WSFG +L ++++ + PY DV+S      +  N   L  P     G+  ++ +C     ++RP+
Sbjct:   11 CIIMEYCAQGQLYEVLRAGRKITPELLYRWTTGIASGMNYLHLHKIIHRDLKSPNVLITHDDLVKISDFGTSKELMDKSTKMSFAGTVA--------WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYRDVDSSAIIWGVGSNSLHLPVPTSCPDGFKILLTQCWTGKPRNRPS 180

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BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69])

HSP 1 Score: 87.8113 bits (216), Expect = 1.567e-18
Identity = 50/160 (31.25%), Postives = 88/160 (55.00%), Query Frame = 3

Query:  969 VELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNF-YLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAEN 1442
            V++ N Y   ++L +V E++ GG+L   ++ + +   +I   C  +L+ L +LHG+ +IHR+I  +S+L+  +G  KL++F + ++     T    L G            +APEV+   PYG + DVWS G M+I++V  + PY +   +QA   I +N
Sbjct:  477 VDMYNSYLVADELWVVMEFLEGGALTDIVTHTRMNEEQIATVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRIKLSDFGFCAQVSKEVTRRKSLVGT--------PYWMAPEVISRLPYGPEVDVWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDN 628

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: PRKCD (protein kinase C delta [Source:HGNC Symbol;Acc:HGNC:9399])

HSP 1 Score: 82.8037 bits (203), Expect = 5.979e-18
Identity = 48/156 (30.77%), Postives = 84/156 (53.85%), Query Frame = 3

Query:  942 LPYATGSPFV-ELINMYTENEKLCIVTEYMTGGSLKSRLSASLGVAEINK---YCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPY 1397
            L  A G P++  L + +   E L  V EY+ GG L   +    G  EI++   Y  +I+ GLQFLH + II+R++  +++L+D +G+ K+ +F + K   N   D+      G+        +APE+++G+ Y    D WSFG +L +++  + P+
Sbjct:   41 LSLAWGHPYLAHLYSTFQTKEHLMFVMEYLNGGDLMFHIQVK-GRFEIDRATFYAAEIVSGLQFLHDQGIIYRDLKLDNILLDKDGHVKIADFGMCK--ENIVGDVRAGTFCGT-----PDYIAPEIVIGQKYNCSVDWWSFGVLLYEMLIGQSPF 188

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 91.6633 bits (226), Expect = 9.476e-20
Identity = 62/202 (30.69%), Postives = 107/202 (52.97%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTI-LYEP--IISGYDAIIARCIRPIQKHRPNAWE-LHNDFL 1556
             V  I+ Y     L ++ EYM GGSL   ++   L   +I   CR+ L GL+FLH + ++HR+I  +++L+   G+ KLT+F     +     ++  + + G+        +APEV+  + YG K D+WS G M+I+++  + PY +   ++A  LIA N T  L EP  + S     +  C+    + R +A E LH++++
Sbjct:  677 IVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINEL--NLKRTTMVGTPY-----WMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYI 871

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 84.3445 bits (207), Expect = 1.530e-17
Identity = 66/199 (33.17%), Postives = 101/199 (50.75%), Query Frame = 3

Query:  993 ENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFL--FNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDA-----IIARCIRPIQKHRPNAWE-LHNDFLD 1559
            E   L I  EY+ GGS+ S L+      E  I  + RQIL G+ +LH + IIHR+I   ++LID  G  K+T+F +SK L   N   +   S + GS        ++PEV+       KAD+WS G ++I++ + K P+PD + +QA   I  N T    P I  +        + +      ++RP+A E L + +LD
Sbjct:  525 EGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRAS-LQGS-----VFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFKIGTNTT----PEIPSWATSEGKNFLRKAFELDYQYRPSALELLQHPWLD 713

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BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700])

HSP 1 Score: 78.9518 bits (193), Expect = 3.318e-16
Identity = 59/234 (25.21%), Postives = 113/234 (48.29%), Query Frame = 3

Query:  777 ELTIISKISTGKFADIYLGKINSFNRDCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGS----------PFV-ELINMYTENEKLCIVTEYMTGGSLKSRLSASL----GVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLI 1433
            +  I+  + TG F  ++L            ++ R N   +   K  K E++ RLK    T            PF+  +   + + +++ ++ +Y+ GG L S L  S      VA+   Y  ++   L++LH + II+R++  E++L+D NG+ K+T+F  +K++ + T    L G            +APEV+  +PY    D WSFG ++ ++++   P+ D N+++ +  I
Sbjct:   86 DFQILRTLGTGSFGRVHL------------IRSRHN-GRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKF--YAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVT--YTLCGTPD--------YIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKI 294

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BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757])

HSP 1 Score: 79.337 bits (194), Expect = 3.319e-16
Identity = 60/216 (27.78%), Postives = 103/216 (47.69%), Query Frame = 3

Query:  969 VELINMYT--ENEKLCIVTEYMTGGSL----KSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPD---VNSIQAFTLI------------AENRTILYEPIISGYDAIIARCIRPIQKHRPNAWELHN 1547
            V    M+T  EN  + I  EYM G SL    K+ L     ++E  + K    +L+GL +LH +K+IHR+I  +++L++ NG  KL +F +S    N     L +  TG+     +  +APE + G+PY   +DVWS G  ++++ + K P        +I  F L+                 I++ P    + + I  C++   + RP+  ++ N
Sbjct:  281 VRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNS----LATTFTGT-----SFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSP---SFKSFIDYCLKKDSRERPSPRQMIN 484

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BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473])

HSP 1 Score: 79.7221 bits (195), Expect = 3.923e-16
Identity = 49/161 (30.43%), Postives = 86/161 (53.42%), Query Frame = 3

Query:  993 ENEKLCIVTEYMTGGSLKSRL-----------SASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAEN 1442
            ++E+L ++ EYM GG L   L           S+ L   ++    ++  +GL+FLH +KIIHR+I  +++L++  G  K+T+F     L    +    + + G+        +APE++  + Y  K DVWS G MLI+++  + PY + + ++A  LIA N
Sbjct:  444 DDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKR--ATMVGTPY-----WMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANN 597

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BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7])

HSP 1 Score: 102.834 bits (255), Expect = 1.638e-24
Identity = 65/195 (33.33%), Postives = 101/195 (51.79%), Query Frame = 3

Query:  969 VELINMYTENEKLCIVTEYMTGGSLKSRLS--ASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDAI--IARCIRPIQKHRPNAWEL 1541
            V+   + T++  + I  EY+ GGS+   +    +L  +   KY RQIL+G+ +LH  +I+HR+I   ++L D  GN KL +F  SK L    +      + G+        +APEV+ GE YG KADVWS G  ++++++ K P+ D   + A   IA   T    P     DA+  +   +R   K RP+A EL
Sbjct:   67 VQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRSKTGFRSVHGTPY-----WMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIATQPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADEL 256

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BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO33667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRJ0])

HSP 1 Score: 94.7449 bits (234), Expect = 1.052e-20
Identity = 56/163 (34.36%), Postives = 90/163 (55.21%), Query Frame = 3

Query:  966 FVELINMYTENEKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDM-LLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT 1448
             V  ++ Y   E+L +V EY+ GGSL   ++ + +   +I   CR+ L+ L+FLH   +IHR+I  +++L+  +G  KLT+F    F    T +    S + G+        +APEV+  + YG + DVWS G M I++V  + PY + N ++A  LIA N T
Sbjct:  283 IVNYVDSYLVGEELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNGVIHRDIKSDNILLGMDGQVKLTDF---GFCATITPEQNKRSTMVGTPY-----WMAPEVVTRKQYGPRVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 437

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BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO45846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL1])

HSP 1 Score: 91.6633 bits (226), Expect = 1.831e-20
Identity = 51/159 (32.08%), Postives = 88/159 (55.35%), Query Frame = 3

Query:  963 PFVELINMYTEN---EKLCIVTEYMTGGSLKSRLSAS-LGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDM-LLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAF 1424
            P   ++ MY  +   ++L +V E++ GG+L   ++ + L   ++   CR +LK L FLH + +IHR+I  +S+L+  NG  KL++F    F    T DM     + G+        +APEV+  +PYG + D+WS G M++++V  + PY +   +QA 
Sbjct:   82 PHPNIVEMYGSHLVGDELWVVMEFLEGGTLTDIVTHTNLSEEQVACVCRAVLKALTFLHSQGVIHRDIKSDSILLTSNGTVKLSDF---GFCAQVTEDMPRRKSLVGTPY-----WMAPEVISRKPYGTEVDIWSLGIMVLEMVDGEPPYFNEPPLQAM 232

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BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO27976 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T7S3])

HSP 1 Score: 82.4185 bits (202), Expect = 1.653e-17
Identity = 58/197 (29.44%), Postives = 98/197 (49.75%), Query Frame = 3

Query:  822 IYLGKINSFNRDC--EVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLS--ASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNG-NAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPY 1397
            +Y+  + SF R+   E  K  Q I D       +  ++ RLK P+      ++ +          I  E+M GGS+   LS       A + +Y RQIL+G+ +LH  +++HR+I   ++L+D  G + ++ +F  +  L    T +  +G    ++      +APEVL GE YG   DVWS G +LI++ + K P+
Sbjct:   64 VYVAALVSFCRNSKSEQDKVCQTIMD-------EIAILARLKHPH-----LIKCLGATRHTGHFNIFLEWMAGGSISMLLSKYGPFEEAILIRYLRQILQGVSYLHENQVVHRDIKGANILVDSTGQDIRIADFGAAARL---ATQITGAGEFQGQLLGTIAFMAPEVLRGESYGRSCDVWSVGCVLIEMATGKPPW 245

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BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO36150 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJF2])

HSP 1 Score: 85.1149 bits (209), Expect = 2.710e-17
Identity = 60/214 (28.04%), Postives = 102/214 (47.66%), Query Frame = 3

Query:  924 VITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLS--ASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNG-NAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPII-----SGYDAIIARCIRPIQKHRPNAWEL 1541
            ++ RLK P+      ++ +          I  E+M GGS+   LS       A + +Y RQIL+G+ +LH  +++HR+I   ++L+D  G + ++ +F  +  L    T +  +G    ++      +APEVL GE YG   DVWS G +LI++ + K P+          LI +    +  P I      G   ++ RC+    + RP A +L
Sbjct:  631 ILARLKHPH-----LIKCLGATRHTGHFNIFLEWMAGGSISMLLSKYGPFEEAILIRYLRQILQGVSYLHENQVVHRDIKGANILVDSTGQDIRIADFGAAARL---ATQITGAGEFQGQLLGTIAFMAPEVLRGESYGRSCDVWSVGCVLIEMATGKPPWNAHEHSNHLALIFKIACAIGPPDIPEHLNPGVRDVVLRCLESKPEDRPAAVDL 836

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BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290])

HSP 1 Score: 115.161 bits (287), Expect = 1.048e-26
Identity = 70/186 (37.63%), Postives = 103/186 (55.38%), Query Frame = 3

Query: 1005 LCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDAIIAR----CIRPIQKHRPNAWEL 1541
            L I  EYM GGS+K +L A   + E    KY RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  SK L   C +   +  +TG+        ++PEV+ GE YG KADVWS G  ++++++ K P+ +  ++ A   IA   T    P++  + +  AR    CI    KHRP+A EL
Sbjct:  430 LTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPY-----WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPT---NPLLPSHTSDQARDFIHCIFVEAKHRPSAEEL 607

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BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 101.293 bits (251), Expect = 3.295e-22
Identity = 55/155 (35.48%), Postives = 88/155 (56.77%), Query Frame = 3

Query:  993 ENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT 1448
            +  KL I  E+M GGS+K +L A   + E    +Y RQIL+G+ +LH   I+HR+I   ++L D +GN KL +F  SK +   C +   +  +TG+        ++PEV+ GE YG KADVWS    ++++++ K P+ +  ++ A   IA   T
Sbjct:  400 DQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKSVTGTPY-----WMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQPT 549

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 101.293 bits (251), Expect = 3.498e-22
Identity = 55/155 (35.48%), Postives = 88/155 (56.77%), Query Frame = 3

Query:  993 ENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT 1448
            +  KL I  E+M GGS+K +L A   + E    +Y RQIL+G+ +LH   I+HR+I   ++L D +GN KL +F  SK +   C +   +  +TG+        ++PEV+ GE YG KADVWS    ++++++ K P+ +  ++ A   IA   T
Sbjct:  430 DQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKSVTGTPY-----WMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQPT 579

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 101.293 bits (251), Expect = 3.498e-22
Identity = 55/155 (35.48%), Postives = 88/155 (56.77%), Query Frame = 3

Query:  993 ENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRT 1448
            +  KL I  E+M GGS+K +L A   + E    +Y RQIL+G+ +LH   I+HR+I   ++L D +GN KL +F  SK +   C +   +  +TG+        ++PEV+ GE YG KADVWS    ++++++ K P+ +  ++ A   IA   T
Sbjct:  430 DQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKSVTGTPY-----WMSPEVINGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQPT 579

[Close]

BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297])

HSP 1 Score: 100.138 bits (248), Expect = 9.195e-22
Identity = 63/188 (33.51%), Postives = 101/188 (53.72%), Query Frame = 3

Query:  990 TENEKLCIVTEYMTGGSLKSRLSASLGVAE--INKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFN-CTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPI-ISGYDAIIARCIRPIQKHRPNAWEL 1541
            T    L I  E+M GGS+K +L +   + E    +Y RQIL+G+ +LH   I+HR+I   ++L D  GN KL +F  S+ L   C +   +  +TG+        ++PEV+ GE YG KAD+WS G  ++++++ + P+ +  ++ A   IA   T    P+ +S +     R I    K RP+A EL
Sbjct:  461 TMERTLSIFMEHMPGGSIKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSGTGIKSVTGTPY-----WMSPEVISGEGYGRKADIWSVGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPELPVHVSDHCREFLRRIFVETKQRPSADEL 643

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BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000014619.1 (SMESG000014619.1)

HSP 1 Score: 1026.54 bits (2653), Expect = 0.000e+0
Identity = 501/501 (100.00%), Postives = 501/501 (100.00%), Query Frame = 3

Query:   63 MEVITLENVNNSNDIETFEMLISDNLIYLKKKLADRICERVQDIKLFDQRNIAVPPLNNNGRIPCKELYYSIYEEENDDIILHIKRNYCGIPKFFQFPKLTTIGQLISELKTLYNIQKNFYILQGNGSFADNNATLEQCKFDNSKVKIWVGESLIVNITLLNPLNTEDENVTQVIGRFDFSATETVASLKEFILNENKQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVEMSNKLELTIISKISTGKFADIYLGKINSFNRDCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLSASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDAIIARCIRPIQKHRPNAWELHNDFLDPN 1565
            MEVITLENVNNSNDIETFEMLISDNLIYLKKKLADRICERVQDIKLFDQRNIAVPPLNNNGRIPCKELYYSIYEEENDDIILHIKRNYCGIPKFFQFPKLTTIGQLISELKTLYNIQKNFYILQGNGSFADNNATLEQCKFDNSKVKIWVGESLIVNITLLNPLNTEDENVTQVIGRFDFSATETVASLKEFILNENKQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVEMSNKLELTIISKISTGKFADIYLGKINSFNRDCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLSASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDAIIARCIRPIQKHRPNAWELHNDFLDPN
Sbjct:    1 MEVITLENVNNSNDIETFEMLISDNLIYLKKKLADRICERVQDIKLFDQRNIAVPPLNNNGRIPCKELYYSIYEEENDDIILHIKRNYCGIPKFFQFPKLTTIGQLISELKTLYNIQKNFYILQGNGSFADNNATLEQCKFDNSKVKIWVGESLIVNITLLNPLNTEDENVTQVIGRFDFSATETVASLKEFILNENKQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVEMSNKLELTIISKISTGKFADIYLGKINSFNRDCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLSASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIISGYDAIIARCIRPIQKHRPNAWELHNDFLDPN 501

[Close]

BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000014613.1 (SMESG000014613.1)

HSP 1 Score: 599.356 bits (1544), Expect = 0.000e+0
Identity = 312/506 (61.66%), Postives = 380/506 (75.10%), Query Frame = 3

Query:   69 VITLENVNNSNDIETFEMLISDNLIYLKKKLADRICERVQDIKLFDQRNIAVPPLNNNGRIP----CKELYYSIYEEENDDIILHIKRNYCGIPKFFQFPKLTTIGQLISELKTLYNIQKNFYILQGNGSFADNNATLEQCKFDNSKVKIWVGESLIVNITLLNPLNTEDENVTQVIGRFDFSATETVASLKEFILNENKQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVEMSNKLELTIISKISTG-KFADIYLGKIN-SFNRDCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLS-ASLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEP---IISGYDAIIARCIRPIQKHRPNAWELHNDFL 1556
            +I L ++   N + TFE+L SDN++YLK KL+D+I  R QD ++    ++   PLN+N  I        L+Y+I +E++DDIIL++KRNYCGIPKF QFPKLTTIGQLISELKTLYNIQKNFYI Q NGSFADNNATLEQCKFDNSKVKIWVGE+ IVNITLLNPLNTED+N   VIGRF+FSATETVASLKEFILNENKQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCV+MS + ++ I +   T  K+   Y G IN S    C    Y   ++D N+ K  KYE++TRLKL Y    PFVEL+ MYTE + L IVTE M GGSL+ +LS A L  + I KYC+QIL+GL+F+H EKIIHRNINC SVL+DG GN KL+NF+ SKFL+N +TDM+  GI G+++DDD CCVAPEVLLGEPYGF+AD+WSFGA LI+IV+ +RPYP +   +A  +I   + I YE      + +D II +CI PIQ +RP    L +D+ 
Sbjct:    5 LIKLTDLFTQNSVNTFEILQSDNVVYLKVKLSDKIGGRAQDFQIHSTDSVN-NPLNDNRSISDISFAGNLFYTISKEQSDDIILYVKRNYCGIPKFLQFPKLTTIGQLISELKTLYNIQKNFYIFQENGSFADNNATLEQCKFDNSKVKIWVGENYIVNITLLNPLNTEDKN---VIGRFEFSATETVASLKEFILNENKQFHNLQLFTETSFLDDKKQLASYPLDRECKIYCVDMSKRTDIIINTADKTKEKYYARYPGTINSSVIEKCVAYAYDCKLTDINSMKILKYEIVTRLKLSYKY--PFVELLTMYTEQDNLFIVTEDMPGGSLRQQLSIAPLEASVIIKYCQQILEGLKFMHDEKIIHRNINCGSVLLDGKGNVKLSNFHFSKFLYNLSTDMIFMGIKGTRIDDDACCVAPEVLLGEPYGFQADIWSFGATLIEIVTRERPYPKLTYKKAIYIIKNEKKIDYERNCYAGTNFDEIIDKCISPIQSNRPTVSFLIDDYF 504

[Close]

BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000014940.1 (SMESG000014940.1)

HSP 1 Score: 256.144 bits (653), Expect = 2.090e-78
Identity = 169/499 (33.87%), Postives = 268/499 (53.71%), Query Frame = 3

Query:   72 ITLENVNNSNDIETFEMLISDNLIYLKKKLADRICERVQDIKLFDQRNIAVPPLNNNGRIPC--KELYYSIYEEENDDIILHIKRNYCGIPKFFQFPKLTTIGQLISELKTLYNIQ-KNFYILQGNGSFADNNATLEQCKFDNSKVKIWVGESLIVNITLLNPLNTEDENVTQVIGRFDFSATETVASLKEFI---LNENKQFHNLQLFTETSFLDDKKQLASYPLDRE-CKIYCVEMSNKLELTIISKISTGKFADIYLGKINSFNRDCEVLKYR---QNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLSA-SLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIIS-GYDAIIARCIRPIQKHRPNA 1532
            IT +N+ N+   E       DN + +KK+++D I   V  I LF +R      LN+N  I    K ++Y + +   + I++ + +N+  IPK+ Q     T+ QL   L +      K F   +      DN A       + SK+K+W G  L+V + + +PL  +    TQ     + S TE++ +LK+ I   ++  K+   L LFTETSFL D K L  YP+ RE C+IY  ++  +    I   ++ G++A I+ G+   FN    + +Y+   + + D N  +   YE++TR+ L  A  S F EL+ MY +++   IVT++M  GSLK   +A  L   EI +Y  QI + L ++H  ++IHR+++C SVL+  + N KL+NF LS++LF  TT  LL GI GSK++     +APEVL  +PYG K+D+WSFG  ++++++  RPYP++N +     I  N+ I Y   IS      I +C+   Q  RP A
Sbjct:    7 ITCQNIQNNQKCEVI-CSTDDNAVIIKKRISDLINIEVHKINLFAER---WQRLNDNDFIDSNIKLIFYEVSQPITEKIVVQMMKNHFNIPKWIQVKTEATVLQLKKILSSFSESHLKTFLFTEAGEMLLDNTAIKSYDLMNASKLKVWRGNDLLVQLEICDPLAKDPS--TQKRFPLEISVTESIINLKKKISEKISIGKEI-KLALFTETSFLQDGKCLLDYPIPRENCQIYYADLIKEETANIKGPLAEGRYARIFEGEFGQFNERVAIKRYKIEERRVEDANILR---YEIVTRIMLSKANVSRFAELMAMYDDSKYFYIVTDFMEQGSLKDIYTARQLNDHEIIRYSIQISEALDYMHSNRLIHRDLSCSSVLVGSDNNIKLSNFQLSEYLF--TTAQLLEGIPGSKIESQQLWLAPEVLHKKPYGIKSDIWSFGVTVMEMLTRDRPYPNMNIVSGSHKICNNKCIEYNKNISPKISEFIDKCLHECQCERPTA 493

[Close]

BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000014940.1 (SMESG000014940.1)

HSP 1 Score: 173.711 bits (439), Expect = 7.808e-50
Identity = 94/250 (37.60%), Postives = 148/250 (59.20%), Query Frame = 3

Query:  798 ISTGKFADIYLGKINSFNRDCEVLKYR---QNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLSA-SLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIIS-GYDAIIARCIRPIQKHRPNA 1532
            ++ G++A I+ G+   FN    + +Y+   + + D N  +   YE++TR+ L  A  S F EL+ MY +++   IVT++M  GSLK   +A  L   EI +Y  QI + L ++H  ++IHR+++C SVL+  + N KL+NF LS++LF  TT  LL GI GSK++     +APEVL  +PYG K+D+WSFG  ++++++  RPYP++N +     I  N+ I Y   IS      I +C+   Q  RP A
Sbjct:   21 LAEGRYARIFEGEFGQFNERVAIKRYKIEERRVEDANILR---YEIVTRIMLSKANVSRFAELMAMYDDSKYFYIVTDFMEQGSLKDIYTARQLNDHEIIRYSIQISEALDYMHSNRLIHRDLSCSSVLVGSDNNIKLSNFQLSEYLF--TTAQLLEGIPGSKIESQQLWLAPEVLHKKPYGIKSDIWSFGVTVMEMLTRDRPYPNMNIVSGSHKICNNKCIEYNKNISPKISEFIDKCLHECQCERPTA 265

[Close]

BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000014940.1 (SMESG000014940.1)

HSP 1 Score: 173.711 bits (439), Expect = 9.957e-50
Identity = 94/250 (37.60%), Postives = 148/250 (59.20%), Query Frame = 3

Query:  798 ISTGKFADIYLGKINSFNRDCEVLKYR---QNISDFNNFKNSKYEVITRLKLPYATGSPFVELINMYTENEKLCIVTEYMTGGSLKSRLSA-SLGVAEINKYCRQILKGLQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGITGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNSIQAFTLIAENRTILYEPIIS-GYDAIIARCIRPIQKHRPNA 1532
            ++ G++A I+ G+   FN    + +Y+   + + D N  +   YE++TR+ L  A  S F EL+ MY +++   IVT++M  GSLK   +A  L   EI +Y  QI + L ++H  ++IHR+++C SVL+  + N KL+NF LS++LF  TT  LL GI GSK++     +APEVL  +PYG K+D+WSFG  ++++++  RPYP++N +     I  N+ I Y   IS      I +C+   Q  RP A
Sbjct:   32 LAEGRYARIFEGEFGQFNERVAIKRYKIEERRVEDANILR---YEIVTRIMLSKANVSRFAELMAMYDDSKYFYIVTDFMEQGSLKDIYTARQLNDHEIIRYSIQISEALDYMHSNRLIHRDLSCSSVLVGSDNNIKLSNFQLSEYLF--TTAQLLEGIPGSKIESQQLWLAPEVLHKKPYGIKSDIWSFGVTVMEMLTRDRPYPNMNIVSGSHKICNNKCIEYNKNISPKISEFIDKCLHECQCERPTA 276

The following BLAST results are available for this feature:

BLAST of Serine/threonine kinase vs. Ensembl Human
BLAST of Serine/threonine kinase vs. Ensembl Celegans
BLAST of Serine/threonine kinase vs. Ensembl Fly
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
BLAST of Serine/threonine kinase vs. Ensembl Mouse
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
BLAST of Serine/threonine kinase vs. TrEMBL
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
BLAST of Serine/threonine kinase vs. Ensembl Yeast
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
BLAST of Serine/threonine kinase vs. Ensembl Medaka
BLAST of Serine/threonine kinase vs. Planmine SMEST

BLAST of Serine/threonine kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MAP3K3	2.883e-24	37.16	mitogen-activated protein kinase kinase kinase 3 [...	[more]
MAP3K3	2.999e-24	37.16	mitogen-activated protein kinase kinase kinase 3 [...	[more]
MAP3K3	3.122e-24	37.16	mitogen-activated protein kinase kinase kinase 3 [...	[more]
MAP3K3	3.122e-24	37.16	mitogen-activated protein kinase kinase kinase 3 [...	[more]
MAP3K3	3.380e-24	37.16	mitogen-activated protein kinase kinase kinase 3 [...	[more]

BLAST of Serine/threonine kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gck-1	8.683e-21	26.48	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]
F26E4.5	1.050e-20	26.38	Tyrosine-protein kinase [Source:UniProtKB/TrEMBL;...	[more]
gck-1	4.902e-20	25.37	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]
gck-1	4.404e-19	25.97	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]
gck-1	5.486e-19	25.83	Germinal center kinase 1 [Source:UniProtKB/Swiss-...	[more]

BLAST of Serine/threonine kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pak	6.830e-20	32.30	gene:FBgn0267698 transcript:FBtr0334539	[more]
Pak	6.830e-20	32.30	gene:FBgn0267698 transcript:FBtr0081714	[more]
Pak	6.830e-20	32.30	gene:FBgn0267698 transcript:FBtr0081716	[more]
Pak	6.830e-20	32.30	gene:FBgn0267698 transcript:FBtr0081715	[more]
Pak	6.830e-20	32.30	gene:FBgn0267698 transcript:FBtr0334544	[more]

BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map3k3	1.501e-26	38.83	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k3	1.607e-26	38.83	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k3	1.995e-26	38.83	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k2	4.713e-22	33.51	mitogen-activated protein kinase kinase kinase 2 [...	[more]
map3k2	4.857e-22	33.51	mitogen-activated protein kinase kinase kinase 2 [...	[more]

BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
MAP3K2	1.819e-23	36.54	mitogen-activated protein kinase kinase kinase 2 [...	[more]
dennd1a	2.492e-23	35.87	DENN domain containing 1A [Source:Xenbase;Acc:XB-G...	[more]
MAP3K2	2.711e-23	36.54	mitogen-activated protein kinase kinase kinase 2 [...	[more]
dennd1a	2.731e-23	35.87	DENN domain containing 1A [Source:Xenbase;Acc:XB-G...	[more]
samd8	1.082e-22	37.75	sterile alpha motif domain containing 8 [Source:Xe...	[more]

BLAST of Serine/threonine kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Map3k3	3.000e-24	37.16	mitogen-activated protein kinase kinase kinase 3 [...	[more]
Map3k2	1.568e-23	35.29	mitogen-activated protein kinase kinase kinase 2 [...	[more]
Pak2	8.815e-21	34.97	p21 (RAC1) activated kinase 2 [Source:MGI Symbol;A...	[more]
Stk25	3.858e-20	27.86	serine/threonine kinase 25 (yeast) [Source:MGI Sym...	[more]
Pak1	7.736e-20	33.13	p21 (RAC1) activated kinase 1 [Source:MGI Symbol;A...	[more]

BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q99759\|M3K3_HUMAN	1.440e-23	37.16	Mitogen-activated protein kinase kinase kinase 3 O...	[more]
sp\|Q61084\|M3K3_MOUSE	2.099e-23	37.16	Mitogen-activated protein kinase kinase kinase 3 O...	[more]
sp\|Q9Y2U5\|M3K2_HUMAN	9.507e-23	35.29	Mitogen-activated protein kinase kinase kinase 2 O...	[more]
sp\|Q6BNF3\|STE20_DEBHA	2.341e-21	34.17	Serine/threonine-protein kinase STE20 OS=Debaryomy...	[more]
sp\|Q61083\|M3K2_MOUSE	1.174e-20	34.22	Mitogen-activated protein kinase kinase kinase 2 O...	[more]

BLAST of Serine/threonine kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A3Q2CUL5	1.212e-24	38.92	Mitogen-activated protein kinase kinase kinase 3 O...	[more]
A0A3Q2CUJ6	1.683e-24	38.92	Mitogen-activated protein kinase kinase kinase 3 O...	[more]
A0A087Y7U3	1.912e-24	39.36	Mitogen-activated protein kinase kinase kinase 3 O...	[more]
A0A3B3YHL3	2.232e-24	39.36	Mitogen-activated protein kinase kinase kinase 3 O...	[more]
M4A106	2.273e-24	39.36	Mitogen-activated protein kinase kinase kinase 3 O...	[more]

BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map3k3	6.050e-26	38.22	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k3	6.050e-26	38.22	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k3	6.050e-26	38.22	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k2	1.152e-22	34.57	mitogen-activated protein kinase kinase kinase 2 [...	[more]
stk25a	4.246e-22	30.74	serine/threonine-protein kinase 25 [Source:NCBI ge...	[more]

BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map3k2	2.262e-25	36.36	mitogen-activated protein kinase kinase kinase 2 [...	[more]
ENSPMAT00000008193.1	4.253e-19	30.00	pep scaffold:Pmarinus_7.0:GL476850:102262:127365:-...	[more]
ENSPMAT00000002088.1	6.135e-19	29.78	pep scaffold:Pmarinus_7.0:GL478600:446:35095:-1 ge...	[more]
pak4	1.567e-18	31.25	p21 protein (Cdc42/Rac)-activated kinase 4 [Source...	[more]
PRKCD	5.979e-18	30.77	protein kinase C delta [Source:HGNC Symbol;Acc:HGN...	[more]

BLAST of Serine/threonine kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
STE20	9.476e-20	30.69	Cdc42p-activated signal transducing kinase; involv...	[more]
STE11	1.530e-17	33.17	Signal transducing MEK kinase; involved in pheromo...	[more]
TPK1	3.318e-16	25.21	cAMP-dependent protein kinase catalytic subunit; p...	[more]
MKK1	3.319e-16	27.78	MAPKK involved in the protein kinase C signaling p...	[more]
SKM1	3.923e-16	30.43	Member of the PAK family of serine/threonine prote...	[more]

BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO41410	1.638e-24	33.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33667	1.052e-20	34.36	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45846	1.831e-20	32.08	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO27976	1.653e-17	29.44	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36150	2.710e-17	28.04	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Serine/threonine kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
map3k3	1.048e-26	37.63	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k22	3.295e-22	35.48	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k22	3.498e-22	35.48	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k22	3.498e-22	35.48	mitogen-activated protein kinase kinase kinase 3 [...	[more]
map3k2	9.195e-22	33.51	mitogen-activated protein kinase kinase kinase 2 [...	[more]

BLAST of Serine/threonine kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000014619.1	0.000e+0	100.00	SMESG000014619.1	[more]
SMESG000014613.1	0.000e+0	61.66	SMESG000014613.1	[more]
SMESG000014940.1	2.090e-78	33.87	SMESG000014940.1	[more]
SMESG000014940.1	7.808e-50	37.60	SMESG000014940.1	[more]
SMESG000014940.1	9.957e-50	37.60	SMESG000014940.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30017337 ID=SMED30017337|Name=Serine/threonine kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1693bp
CCTAGATTAAAAGTTCTTGTTTAAATAATATATTTTTTTGTAACTTCCTT
TTGAATAAAGTAATGGAAGTAATTACTTTAGAAAATGTTAACAACTCAAA
TGACATTGAAACATTTGAAATGTTGATATCTGATAATCTTATATATCTAA
AGAAAAAATTAGCAGACAGAATTTGTGAAAGAGTGCAAGACATTAAGTTA
TTTGATCAAAGAAATATAGCCGTTCCACCATTAAATAATAATGGTAGGAT
TCCTTGCAAAGAGTTATATTATTCAATTTATGAAGAAGAAAATGACGACA
TAATTCTCCACATTAAGCGCAATTATTGCGGCATTCCGAAGTTTTTCCAA
TTTCCGAAACTTACTACAATCGGCCAATTAATTTCGGAATTGAAAACATT
ATATAATATTCAAAAGAATTTCTATATATTGCAAGGAAATGGCTCGTTTG
CTGACAATAATGCGACATTGGAGCAATGCAAATTCGACAATTCAAAGGTC
AAAATATGGGTGGGTGAAAGTTTAATTGTCAACATTACCCTTCTGAATCC
ACTGAACACAGAGGATGAAAATGTCACTCAAGTTATTGGTAGATTTGATT
TCTCAGCTACGGAAACGGTTGCTAGTTTAAAGGAATTTATTCTAAATGAA
AATAAACAATTTCATAATTTACAACTGTTTACAGAAACATCATTTTTAGA
CGATAAGAAGCAATTAGCAAGCTATCCGCTTGACAGAGAGTGCAAAATTT
ATTGTGTAGAGATGTCGAATAAGCTCGAATTGACAATTATATCCAAAATC
AGCACCGGAAAATTTGCCGATATATACCTCGGGAAAATCAACTCCTTTAA
CCGGGATTGTGAAGTGCTTAAATATAGGCAAAATATTTCTGATTTTAACA
ATTTCAAAAATTCGAAATATGAAGTTATAACTCGTCTCAAATTACCATAC
GCAACGGGATCTCCATTTGTGGAACTTATAAACATGTATACAGAGAACGA
GAAGCTTTGCATAGTTACTGAATACATGACTGGAGGATCTCTGAAGTCAC
GTTTGTCGGCTTCGTTGGGAGTTGCGGAAATCAACAAATATTGTCGACAA
ATACTTAAAGGATTGCAGTTCTTGCACGGAGAGAAGATAATTCACCGCAA
TATAAACTGCGAAAGCGTTCTAATCGATGGAAATGGCAATGCGAAATTGA
CAAACTTTTACTTGTCTAAGTTCCTCTTCAATTGTACAACAGACATGCTA
TTGAGCGGCATTACCGGATCCAAGGTCGATGACGATACCTGTTGTGTTGC
ACCGGAAGTGCTGCTAGGGGAACCTTATGGATTTAAAGCTGACGTTTGGT
CGTTCGGAGCGATGCTAATTCAGATCGTTTCACTGAAACGGCCGTATCCA
GATGTAAATAGCATTCAAGCCTTTACACTGATTGCCGAGAATAGGACAAT
TCTTTATGAGCCTATTATATCCGGTTACGATGCAATCATTGCCAGGTGCA
TTAGACCGATACAAAAACACAGACCAAATGCCTGGGAACTTCATAATGAC
TTTCTGGATCCTAATTGATTGACTTTCTAGACATTTCTAGGATTTCAGCA
GAATTCCAATTGTAATGTCACATTTCTGCGATATTTAGATTAGGATTTGC
TAACAGTTTTTAATAAAATTCTAAAAATCCTGAAAGATTGTTG

protein sequence of SMED30017337-orf-1

>SMED30017337-orf-1 ID=SMED30017337-orf-1|Name=SMED30017337-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=502bp
MEVITLENVNNSNDIETFEMLISDNLIYLKKKLADRICERVQDIKLFDQR
NIAVPPLNNNGRIPCKELYYSIYEEENDDIILHIKRNYCGIPKFFQFPKL
TTIGQLISELKTLYNIQKNFYILQGNGSFADNNATLEQCKFDNSKVKIWV
GESLIVNITLLNPLNTEDENVTQVIGRFDFSATETVASLKEFILNENKQF
HNLQLFTETSFLDDKKQLASYPLDRECKIYCVEMSNKLELTIISKISTGK
FADIYLGKINSFNRDCEVLKYRQNISDFNNFKNSKYEVITRLKLPYATGS
PFVELINMYTENEKLCIVTEYMTGGSLKSRLSASLGVAEINKYCRQILKG
LQFLHGEKIIHRNINCESVLIDGNGNAKLTNFYLSKFLFNCTTDMLLSGI
TGSKVDDDTCCVAPEVLLGEPYGFKADVWSFGAMLIQIVSLKRPYPDVNS
IQAFTLIAENRTILYEPIISGYDAIIARCIRPIQKHRPNAWELHNDFLDP
N*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0010468	regulation of gene expression
GO:0006468	protein phosphorylation
GO:0035376	sterol import
GO:0043065	positive regulation of apoptotic process
GO:0043991	histone H2B-S14 phosphorylation
GO:1990872	negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter
GO:0000011	vacuole inheritance
GO:0000165	MAPK cascade
GO:0000185	activation of MAPKKK activity
GO:0000750	pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0001402	signal transduction involved in filamentous growth
GO:0001403	invasive growth in response to glucose limitation
GO:0007096	regulation of exit from mitosis
GO:0007118	budding cell apical bud growth
GO:0007121	bipolar cellular bud site selection
GO:0007124	pseudohyphal growth
GO:0007232	osmosensory signaling pathway via Sho1 osmosensor
GO:0010629	negative regulation of gene expression
GO:0016310	phosphorylation
GO:0019236	response to pheromone
GO:0034063	stress granule assembly
GO:0034605	cellular response to heat

Vocabulary: **molecular function**
Term	Definition
GO:0019899	enzyme binding
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0042802	identical protein binding
GO:0044025	histone kinase activity (H2B-S14 specific)
GO:0000166	nucleotide binding
GO:0004674	protein serine/threonine kinase activity
GO:0008349	MAP kinase kinase kinase kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR000719	Prot_kinase_dom
IPR011009	Kinase-like_dom_sf

Vocabulary: **cellular component**
Term	Definition
GO:0043332	mating projection tip
GO:0000131	incipient cellular bud site
GO:0005634	nucleus
GO:0005737	cytoplasm

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 221..499 e-value: 1.5E-45 score: 157.4
None	No IPR available	PANTHER	PTHR45832	FAMILY NOT NAMED	coord: 303..493
None	No IPR available	CDD	cd17039	Ubl_ubiquitin_like	coord: 177..232 e-value: 0.00379551 score: 34.109
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PFAM	PF07714	Pkinase_Tyr	coord: 241..496 e-value: 2.8E-30 score: 105.5
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 240..498 score: 28.019
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 240..498

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Serine/threonine kinase

Zeng et. al., 2018

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Owlery

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