Mitofusin 1

Overview
NameMitofusin 1
Smed IDSMED30017290
Length (bp)3507
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mitofusin 1 (SMED30017290) t-SNE clustered cells

Violin plots show distribution of expression levels for Mitofusin 1 (SMED30017290) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mitofusin 1 (SMED30017290) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mitofusin 1 (SMED30017290) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30017290

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30017290SMESG000070111.1 SmedASXL_033993SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
head regionSMED30017290SMESG000070111.1 SmedASXL_010585SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30017290SMESG000070111.1 dd_Smed_v4_16499_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30017290SMESG000070111.1 dd_Smed_v4_16499_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30017290SMESG000070111.1 dd_Smed_v4_16499_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
head regionSMED30017290SMESG000070111.1 dd_Smed_v6_16499_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mitofusin 1 vs. Ensembl Human
Match: MFN1 (mitofusin 1 [Source:HGNC Symbol;Acc:HGNC:18262])

HSP 1 Score: 82.8037 bits (203), Expect = 5.610e-16
Identity = 60/205 (29.27%), Postives = 106/205 (51.71%), Query Frame = 1 
Query:  226 KDRFVELE---NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            +D  VE++   ++L+ I E +S++++K+ FFG  SSGK+ +INA+L  +   S + H T CF+ +  +   K  ++ +             +E + + T N+   ++  +        V+VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S
Sbjct:   51 EDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGS-----------DEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKA-KCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDAS 242
[Close]
BLAST of Mitofusin 1 vs. Ensembl Human
Match: MFN1 (mitofusin 1 [Source:HGNC Symbol;Acc:HGNC:18262])

HSP 1 Score: 82.8037 bits (203), Expect = 2.374e-15
Identity = 60/205 (29.27%), Postives = 106/205 (51.71%), Query Frame = 1 
Query:  226 KDRFVELE---NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            +D  VE++   ++L+ I E +S++++K+ FFG  SSGK+ +INA+L  +   S + H T CF+ +  +   K  ++ +             +E + + T N+   ++  +        V+VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S
Sbjct:   51 EDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGS-----------DEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKA-KCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDAS 242
[Close]
BLAST of Mitofusin 1 vs. Ensembl Human
Match: MFN1 (mitofusin 1 [Source:HGNC Symbol;Acc:HGNC:18262])

HSP 1 Score: 82.8037 bits (203), Expect = 2.374e-15
Identity = 60/205 (29.27%), Postives = 106/205 (51.71%), Query Frame = 1 
Query:  226 KDRFVELE---NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            +D  VE++   ++L+ I E +S++++K+ FFG  SSGK+ +INA+L  +   S + H T CF+ +  +   K  ++ +             +E + + T N+   ++  +        V+VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S
Sbjct:   51 EDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGS-----------DEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKA-KCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDAS 242
[Close]
BLAST of Mitofusin 1 vs. Ensembl Human
Match: MFN2 (mitofusin 2 [Source:HGNC Symbol;Acc:HGNC:16877])

HSP 1 Score: 78.1814 bits (191), Expect = 5.977e-14
Identity = 56/194 (28.87%), Postives = 99/194 (51.03%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVS---EEDERFFNIRINRTTKPDIFILVNKWDQS 801
            +++  I E ++++++K+ FFG  S+GK+ +INA+L  +   S + HTT CF+ + +  D        ++ F+    +   EE     T N+   ++ Q+        V V  P      +LK ++ L+DSPG     EL   +     DAD+ + L+ N  S   + ++ FF+    R ++P+IFIL N+WD S
Sbjct:   83 SKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRV-EGTDG-------HEAFLLTEGS---EEKRSAKTVNQLAHALHQDKQLHAGSLVSVMWP-NSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFV-LVANSESTLMQTEKHFFHKVSERLSRPNIFILNNRWDAS 263
[Close]
BLAST of Mitofusin 1 vs. Ensembl Human
Match: MFN2 (mitofusin 2 [Source:HGNC Symbol;Acc:HGNC:16877])

HSP 1 Score: 78.1814 bits (191), Expect = 5.977e-14
Identity = 56/194 (28.87%), Postives = 99/194 (51.03%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVS---EEDERFFNIRINRTTKPDIFILVNKWDQS 801
            +++  I E ++++++K+ FFG  S+GK+ +INA+L  +   S + HTT CF+ + +  D        ++ F+    +   EE     T N+   ++ Q+        V V  P      +LK ++ L+DSPG     EL   +     DAD+ + L+ N  S   + ++ FF+    R ++P+IFIL N+WD S
Sbjct:   83 SKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRV-EGTDG-------HEAFLLTEGS---EEKRSAKTVNQLAHALHQDKQLHAGSLVSVMWP-NSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFV-LVANSESTLMQTEKHFFHKVSERLSRPNIFILNNRWDAS 263
[Close]
BLAST of Mitofusin 1 vs. Ensembl Celegans
Match: fzo-1 (Transmembrane GTPase fzo-1 [Source:UniProtKB/Swiss-Prot;Acc:Q23424])

HSP 1 Score: 82.8037 bits (203), Expect = 8.764e-16
Identity = 74/282 (26.24%), Postives = 138/282 (48.94%), Query Frame = 1 
Query:   19 FSFTSKLVHCMISFVQSAQNNNKKMS------QNIDSDARQEMRKAKKLLTEL-----ENYIGFEELCKEWKVQKKIKKFKDRFVE-LENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPD--AKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-VKVFIPIGDDN---KILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCN---DVSEEDERFFNIRINRTTKPDIFILVNKWDQS 801
             S T+ LVH + +   S  +N++ +       +  D++     R+AKK+L ++     +N    E + K+ K    +   +   +E + + +  I +   + N+K+ FFG  S+GK+  INA+L  +     M HTT CF+ +  S       ++    Q+   +   KI      +S  N +  +M Q+S +KVF P   ++   ++L+ +V ++DSPG     E    +  H  DAD+ + L+ N    +++ ++ FF     + +KP++FIL N+WD S
Sbjct:    1 MSGTASLVHTLPA---SGDSNHRGLHSLKNSRRAADNEPLLRFREAKKVLGDVYGELKDNVAELEGVYKDIKENDFVSSEQREEIEAIGDSIKTIMDTFQRDNMKVVFFGRTSNGKSTTINAMLHEKVLPQGMGHTTCCFLQVEGSEGEVGHLQLDDNPQKIDMKMLGKI---GHALSDENSDLPAMGQDSLLKVFHPKKSESGECRLLQNDVVILDSPGVDLSPEFDSWIDKHCLDADVFV-LVSNAESTLTQAEKNFFLRVAKKLSKPNVFILNNRWDAS 275
[Close]
BLAST of Mitofusin 1 vs. Ensembl Fly
Match: fzo (gene:FBgn0011596 transcript:FBtr0084399)

HSP 1 Score: 86.2705 bits (212), Expect = 9.510e-17
Identity = 62/237 (26.16%), Postives = 120/237 (50.63%), Query Frame = 1 
Query:  112 DARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIG-----DDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCND--VSEEDERFFNIRINRTTKPDIFILVNKWDQS 801
            DA+ E+   + +  +L NY+       E  V  K ++  +      +++  I + +S+  +K+ FFG  S+GK+ +INA+L  +   S M HTT CF  +  +   + + V   QE          +E  ++S  ++  S+ S  ++K    +      +   IL  +V L+D+PG     +L +C+ ++  DAD+ I +L  +  VS  + +FF    ++ ++P++FIL N+WD++
Sbjct:   30 DAKTEL---QDIYHDLSNYLSNFLTILEETVLLKDRQMLEHLCAFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQE----------DEHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKA 253
[Close]
BLAST of Mitofusin 1 vs. Ensembl Fly
Match: Marf (gene:FBgn0029870 transcript:FBtr0343373)

HSP 1 Score: 83.1889 bits (204), Expect = 1.018e-15
Identity = 55/200 (27.50%), Postives = 105/200 (52.50%), Query Frame = 1 
Query:  265 IQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFN--KETSSMSQES------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCND--VSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQDSRLCEL 834
            I+E + + ++K+ FFG  S+GK+ +INA+L  +   S + HTT CF  +  S   +  ++ +  E             EK++  N  +  +++ QE       V++F P  +   +L+ +V  +DSPG      L + + NH  +AD+ + +L  +  ++  +++FF+    + +KP+IFIL N+WD S  + + +  EL
Sbjct:  129 IREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSE-------------EKLNVVNIKQLANALCQEKLCESSLVRIFWP-RERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNADVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESEL 314
[Close]
BLAST of Mitofusin 1 vs. Ensembl Fly
Match: Marf (gene:FBgn0029870 transcript:FBtr0070910)

HSP 1 Score: 82.0333 bits (201), Expect = 2.188e-15
Identity = 53/194 (27.32%), Postives = 102/194 (52.58%), Query Frame = 1 
Query:  265 IQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFN--KETSSMSQES------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCND--VSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQD 816
            I+E + + ++K+ FFG  S+GK+ +INA+L  +   S + HTT CF  +  S   +  ++ +  E             EK++  N  +  +++ QE       V++F P  +   +L+ +V  +DSPG      L + + NH  +AD+ + +L  +  ++  +++FF+    + +KP+IFIL N+WD S  + +
Sbjct:  129 IREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSE-------------EKLNVVNIKQLANALCQEKLCESSLVRIFWP-RERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNADVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPE 308
[Close]
BLAST of Mitofusin 1 vs. Ensembl Fly
Match: Marf (gene:FBgn0029870 transcript:FBtr0070909)

HSP 1 Score: 82.0333 bits (201), Expect = 2.188e-15
Identity = 53/194 (27.32%), Postives = 102/194 (52.58%), Query Frame = 1 
Query:  265 IQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFN--KETSSMSQES------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCND--VSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQD 816
            I+E + + ++K+ FFG  S+GK+ +INA+L  +   S + HTT CF  +  S   +  ++ +  E             EK++  N  +  +++ QE       V++F P  +   +L+ +V  +DSPG      L + + NH  +AD+ + +L  +  ++  +++FF+    + +KP+IFIL N+WD S  + +
Sbjct:  129 IREVLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSE-------------EKLNVVNIKQLANALCQEKLCESSLVRIFWP-RERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNADVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPE 308
[Close]
BLAST of Mitofusin 1 vs. Ensembl Zebrafish
Match: mfn1b (mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553])

HSP 1 Score: 85.1149 bits (209), Expect = 3.382e-17
Identity = 64/205 (31.22%), Postives = 108/205 (52.68%), Query Frame = 1 
Query:  226 KDRFVELEN---QLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVS---EEDERFFNIRINRTTKPDIFILVNKWDQS 801
            KD+  E+E+   +L+ IQE ++++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  + + K  +           K +  EE + I T N+   ++  +        VKVF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    + +KP+IFIL N+WD S
Sbjct:   52 KDQLDEIESYTSKLSIIQEVLARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDEDKAFL-----------KTEGSEEEKSIKTVNQLAHALHMDESLDAGCLVKVFWP-KTKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNEKLSKPNIFILNNRWDAS 243
[Close]
BLAST of Mitofusin 1 vs. Ensembl Zebrafish
Match: mfn1b (mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553])

HSP 1 Score: 85.1149 bits (209), Expect = 4.453e-17
Identity = 64/205 (31.22%), Postives = 108/205 (52.68%), Query Frame = 1 
Query:  226 KDRFVELEN---QLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVS---EEDERFFNIRINRTTKPDIFILVNKWDQS 801
            KD+  E+E+   +L+ IQE ++++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  + + K  +           K +  EE + I T N+   ++  +        VKVF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    + +KP+IFIL N+WD S
Sbjct:   52 KDQLDEIESYTSKLSIIQEVLARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDEDKAFL-----------KTEGSEEEKSIKTVNQLAHALHMDESLDAGCLVKVFWP-KTKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNEKLSKPNIFILNNRWDAS 243
[Close]
BLAST of Mitofusin 1 vs. Ensembl Zebrafish
Match: mfn1b (mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553])

HSP 1 Score: 86.2705 bits (212), Expect = 1.455e-16
Identity = 64/205 (31.22%), Postives = 108/205 (52.68%), Query Frame = 1 
Query:  226 KDRFVELEN---QLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            KD+  E+E+   +L+ IQE ++++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  + + K  +           K +  EE + I T N+   ++  +        VKVF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    + +KP+IFIL N+WD S
Sbjct:   52 KDQLDEIESYTSKLSIIQEVLARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDEDKAFL-----------KTEGSEEEKSIKTVNQLAHALHMDESLDAGCLVKVFWP-KTKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNEKLSKPNIFILNNRWDAS 243
[Close]
BLAST of Mitofusin 1 vs. Ensembl Zebrafish
Match: mfn1b (mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553])

HSP 1 Score: 85.8853 bits (211), Expect = 1.529e-16
Identity = 64/205 (31.22%), Postives = 108/205 (52.68%), Query Frame = 1 
Query:  226 KDRFVELEN---QLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            KD+  E+E+   +L+ IQE ++++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  + + K  +           K +  EE + I T N+   ++  +        VKVF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    + +KP+IFIL N+WD S
Sbjct:   52 KDQLDEIESYTSKLSIIQEVLARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDEDKAFL-----------KTEGSEEEKSIKTVNQLAHALHMDESLDAGCLVKVFWP-KTKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNEKLSKPNIFILNNRWDAS 243
[Close]
BLAST of Mitofusin 1 vs. Ensembl Zebrafish
Match: mfn1b (mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553])

HSP 1 Score: 85.8853 bits (211), Expect = 1.529e-16
Identity = 64/205 (31.22%), Postives = 108/205 (52.68%), Query Frame = 1 
Query:  226 KDRFVELEN---QLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            KD+  E+E+   +L+ IQE ++++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  + + K  +           K +  EE + I T N+   ++  +        VKVF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    + +KP+IFIL N+WD S
Sbjct:   52 KDQLDEIESYTSKLSIIQEVLARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDEDKAFL-----------KTEGSEEEKSIKTVNQLAHALHMDESLDAGCLVKVFWP-KTKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNEKLSKPNIFILNNRWDAS 243
[Close]
BLAST of Mitofusin 1 vs. Ensembl Xenopus
Match: mfn1 (mitofusin 1 [Source:NCBI gene;Acc:548943])

HSP 1 Score: 85.1149 bits (209), Expect = 3.982e-16
Identity = 62/210 (29.52%), Postives = 106/210 (50.48%), Query Frame = 1 
Query:  247 ENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE--EDERFFNIRIN-RTTKPDIFILVNKWDQSDQD----QDSRLCEL 834
            + +L  I E ++++N+K+ FFG  SSGK+ +IN++L  +   S + HTT CF+ +  +   K  ++ +             EE + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     E+ F  ++N + +KP+IFIL N+WD S  +    +D   CEL
Sbjct:   72 KTKLAGIGEVLARRNMKVAFFGRTSSGKSTVINSMLWDKVLPSGIGHTTNCFLSVEGTEGDKAYLMTEGS-----------EEKKSVKTVNQLAHALHMDKDLGAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFYKVNEKLSKPNIFILNNRWDASASEPEYMEDVSTCEL 268
[Close]
BLAST of Mitofusin 1 vs. Ensembl Xenopus
Match: mfn1 (mitofusin 1 [Source:NCBI gene;Acc:548943])

HSP 1 Score: 83.1889 bits (204), Expect = 1.886e-15
Identity = 58/200 (29.00%), Postives = 102/200 (51.00%), Query Frame = 1 
Query:  247 ENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE--EDERFFNIRIN-RTTKPDIFILVNKWDQSDQDQD 816
            + +L  I E ++++N+K+ FFG  SSGK+ +IN++L  +   S + HTT CF+ +  +   K  ++ +             EE + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     E+ F  ++N + +KP+IFIL N+WD S  + +
Sbjct:   77 KTKLAGIGEVLARRNMKVAFFGRTSSGKSTVINSMLWDKVLPSGIGHTTNCFLSVEGTEGDKAYLMTEGS-----------EEKKSVKTVNQLAHALHMDKDLGAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFYKVNEKLSKPNIFILNNRWDASASEPE 263
[Close]
BLAST of Mitofusin 1 vs. Ensembl Xenopus
Match: mfn1 (mitofusin 1 [Source:NCBI gene;Acc:548943])

HSP 1 Score: 82.8037 bits (203), Expect = 1.913e-15
Identity = 58/200 (29.00%), Postives = 102/200 (51.00%), Query Frame = 1 
Query:  247 ENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE--EDERFFNIRIN-RTTKPDIFILVNKWDQSDQDQD 816
            + +L  I E ++++N+K+ FFG  SSGK+ +IN++L  +   S + HTT CF+ +  +   K  ++ +             EE + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     E+ F  ++N + +KP+IFIL N+WD S  + +
Sbjct:   77 KTKLAGIGEVLARRNMKVAFFGRTSSGKSTVINSMLWDKVLPSGIGHTTNCFLSVEGTEGDKAYLMTEGS-----------EEKKSVKTVNQLAHALHMDKDLGAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFYKVNEKLSKPNIFILNNRWDASASEPE 263
[Close]
BLAST of Mitofusin 1 vs. Ensembl Xenopus
Match: mfn1 (mitofusin 1 [Source:NCBI gene;Acc:548943])

HSP 1 Score: 82.8037 bits (203), Expect = 1.935e-15
Identity = 58/200 (29.00%), Postives = 102/200 (51.00%), Query Frame = 1 
Query:  247 ENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE--EDERFFNIRIN-RTTKPDIFILVNKWDQSDQDQD 816
            + +L  I E ++++N+K+ FFG  SSGK+ +IN++L  +   S + HTT CF+ +  +   K  ++ +             EE + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     E+ F  ++N + +KP+IFIL N+WD S  + +
Sbjct:   72 KTKLAGIGEVLARRNMKVAFFGRTSSGKSTVINSMLWDKVLPSGIGHTTNCFLSVEGTEGDKAYLMTEGS-----------EEKKSVKTVNQLAHALHMDKDLGAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFYKVNEKLSKPNIFILNNRWDASASEPE 258
[Close]
BLAST of Mitofusin 1 vs. Ensembl Xenopus
Match: mfn1 (mitofusin 1 [Source:NCBI gene;Acc:548943])

HSP 1 Score: 82.8037 bits (203), Expect = 2.084e-15
Identity = 58/199 (29.15%), Postives = 101/199 (50.75%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE--EDERFFNIRIN-RTTKPDIFILVNKWDQSDQDQD 816
             +L  I E ++++N+K+ FFG  SSGK+ +IN++L  +   S + HTT CF+ +  +   K  ++ +             EE + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     E+ F  ++N + +KP+IFIL N+WD S  + +
Sbjct:   63 TKLAGIGEVLARRNMKVAFFGRTSSGKSTVINSMLWDKVLPSGIGHTTNCFLSVEGTEGDKAYLMTEGS-----------EEKKSVKTVNQLAHALHMDKDLGAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFYKVNEKLSKPNIFILNNRWDASASEPE 248
[Close]
BLAST of Mitofusin 1 vs. Ensembl Mouse
Match: Mfn1 (mitofusin 1 [Source:MGI Symbol;Acc:MGI:1914664])

HSP 1 Score: 80.1073 bits (196), Expect = 5.267e-16
Identity = 60/202 (29.70%), Postives = 103/202 (50.99%), Query Frame = 1 
Query:  226 KDRFVELE---NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKW 792
            +D  VE++   N+L  I E +S++++K+ FFG  SSGK+ +INA+L  +   S + HTT CF+ +  +   K  ++ +             +E + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+W
Sbjct:   51 EDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGS-----------DEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRW 239
[Close]
BLAST of Mitofusin 1 vs. Ensembl Mouse
Match: Mfn1 (mitofusin 1 [Source:MGI Symbol;Acc:MGI:1914664])

HSP 1 Score: 83.5741 bits (205), Expect = 9.920e-16
Identity = 62/210 (29.52%), Postives = 107/210 (50.95%), Query Frame = 1 
Query:  226 KDRFVELE---NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQSDQDQD 816
            +D  VE++   N+L  I E +S++++K+ FFG  SSGK+ +INA+L  +   S + HTT CF+ +  +   K  ++ +             +E + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S  + +
Sbjct:   51 EDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGS-----------DEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPE 247
[Close]
BLAST of Mitofusin 1 vs. Ensembl Mouse
Match: Mfn1 (mitofusin 1 [Source:MGI Symbol;Acc:MGI:1914664])

HSP 1 Score: 83.5741 bits (205), Expect = 9.920e-16
Identity = 62/210 (29.52%), Postives = 107/210 (50.95%), Query Frame = 1 
Query:  226 KDRFVELE---NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQSDQDQD 816
            +D  VE++   N+L  I E +S++++K+ FFG  SSGK+ +INA+L  +   S + HTT CF+ +  +   K  ++ +             +E + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S  + +
Sbjct:   51 EDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGS-----------DEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPE 247
[Close]
BLAST of Mitofusin 1 vs. Ensembl Mouse
Match: Mfn2 (mitofusin 2 [Source:MGI Symbol;Acc:MGI:2442230])

HSP 1 Score: 80.1073 bits (196), Expect = 1.036e-14
Identity = 55/194 (28.35%), Postives = 101/194 (52.06%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVS---EEDERFFNIRINRTTKPDIFILVNKWDQS 801
            +++  I E ++++++K+ FFG  S+GK+ +INA+L  +   S + HTT CF+ +  +          ++ F+    +   EE + + T N+   ++ Q+        V V  P      +LK ++ L+DSPG     EL   +     DAD+ + L+ N  S   + +++FF+    R ++P+IFIL N+WD S
Sbjct:   83 SKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGT--------DGHEAFLLTEGS---EEKKSVKTVNQLAHALHQDEQLHAGSMVSVMWP-NSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFV-LVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWDAS 263
[Close]
BLAST of Mitofusin 1 vs. Ensembl Mouse
Match: Mfn2 (mitofusin 2 [Source:MGI Symbol;Acc:MGI:2442230])

HSP 1 Score: 80.1073 bits (196), Expect = 1.036e-14
Identity = 55/194 (28.35%), Postives = 101/194 (52.06%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVS---EEDERFFNIRINRTTKPDIFILVNKWDQS 801
            +++  I E ++++++K+ FFG  S+GK+ +INA+L  +   S + HTT CF+ +  +          ++ F+    +   EE + + T N+   ++ Q+        V V  P      +LK ++ L+DSPG     EL   +     DAD+ + L+ N  S   + +++FF+    R ++P+IFIL N+WD S
Sbjct:   83 SKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGT--------DGHEAFLLTEGS---EEKKSVKTVNQLAHALHQDEQLHAGSMVSVMWP-NSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFV-LVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWDAS 263
[Close]
BLAST of Mitofusin 1 vs. UniProt/SwissProt
Match: sp|O18412|FZO_DROME (Transmembrane GTPase fzo OS=Drosophila melanogaster OX=7227 GN=fzo PE=1 SV=2)

HSP 1 Score: 86.2705 bits (212), Expect = 9.533e-16
Identity = 62/237 (26.16%), Postives = 120/237 (50.63%), Query Frame = 1 
Query:  112 DARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIG-----DDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCND--VSEEDERFFNIRINRTTKPDIFILVNKWDQS 801
            DA+ E+   + +  +L NY+       E  V  K ++  +      +++  I + +S+  +K+ FFG  S+GK+ +INA+L  +   S M HTT CF  +  +   + + V   QE          +E  ++S  ++  S+ S  ++K    +      +   IL  +V L+D+PG     +L +C+ ++  DAD+ I +L  +  VS  + +FF    ++ ++P++FIL N+WD++
Sbjct:   30 DAKTEL---QDIYHDLSNYLSNFLTILEETVLLKDRQMLEHLCAFSSRVEAIAKVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQE----------DEHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCMDADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKA 253
[Close]
BLAST of Mitofusin 1 vs. UniProt/SwissProt
Match: sp|Q8R4Z9|MFN1_RAT (Mitofusin-1 OS=Rattus norvegicus OX=10116 GN=Mfn1 PE=1 SV=1)

HSP 1 Score: 83.5741 bits (205), Expect = 6.535e-15
Identity = 62/210 (29.52%), Postives = 107/210 (50.95%), Query Frame = 1 
Query:  226 KDRFVELE---NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQSDQDQD 816
            +D  VE++   N+L  I E +S++++K+ FFG  SSGK+ +INA+L  +   S + HTT CF+ +  +   K  ++ +             +E + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S  + +
Sbjct:   51 EDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGS-----------DEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPE 247
[Close]
BLAST of Mitofusin 1 vs. UniProt/SwissProt
Match: sp|Q811U4|MFN1_MOUSE (Mitofusin-1 OS=Mus musculus OX=10090 GN=Mfn1 PE=1 SV=3)

HSP 1 Score: 83.5741 bits (205), Expect = 6.939e-15
Identity = 62/210 (29.52%), Postives = 107/210 (50.95%), Query Frame = 1 
Query:  226 KDRFVELE---NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQSDQDQD 816
            +D  VE++   N+L  I E +S++++K+ FFG  SSGK+ +INA+L  +   S + HTT CF+ +  +   K  ++ +             +E + + T N+   ++  +        V VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S  + +
Sbjct:   51 EDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGS-----------DEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKA-KCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPE 247
[Close]
BLAST of Mitofusin 1 vs. UniProt/SwissProt
Match: sp|Q23424|FZO1_CAEEL (Transmembrane GTPase fzo-1 OS=Caenorhabditis elegans OX=6239 GN=fzo-1 PE=3 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 1.115e-14
Identity = 74/282 (26.24%), Postives = 138/282 (48.94%), Query Frame = 1 
Query:   19 FSFTSKLVHCMISFVQSAQNNNKKMS------QNIDSDARQEMRKAKKLLTEL-----ENYIGFEELCKEWKVQKKIKKFKDRFVE-LENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPD--AKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-VKVFIPIGDDN---KILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCN---DVSEEDERFFNIRINRTTKPDIFILVNKWDQS 801
             S T+ LVH + +   S  +N++ +       +  D++     R+AKK+L ++     +N    E + K+ K    +   +   +E + + +  I +   + N+K+ FFG  S+GK+  INA+L  +     M HTT CF+ +  S       ++    Q+   +   KI      +S  N +  +M Q+S +KVF P   ++   ++L+ +V ++DSPG     E    +  H  DAD+ + L+ N    +++ ++ FF     + +KP++FIL N+WD S
Sbjct:    1 MSGTASLVHTLPA---SGDSNHRGLHSLKNSRRAADNEPLLRFREAKKVLGDVYGELKDNVAELEGVYKDIKENDFVSSEQREEIEAIGDSIKTIMDTFQRDNMKVVFFGRTSNGKSTTINAMLHEKVLPQGMGHTTCCFLQVEGSEGEVGHLQLDDNPQKIDMKMLGKI---GHALSDENSDLPAMGQDSLLKVFHPKKSESGECRLLQNDVVILDSPGVDLSPEFDSWIDKHCLDADVFV-LVSNAESTLTQAEKNFFLRVAKKLSKPNVFILNNRWDAS 275
[Close]
BLAST of Mitofusin 1 vs. UniProt/SwissProt
Match: sp|Q8IWA4|MFN1_HUMAN (Mitofusin-1 OS=Homo sapiens OX=9606 GN=MFN1 PE=1 SV=3)

HSP 1 Score: 82.8037 bits (203), Expect = 1.140e-14
Identity = 60/205 (29.27%), Postives = 106/205 (51.71%), Query Frame = 1 
Query:  226 KDRFVELE---NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            +D  VE++   ++L+ I E +S++++K+ FFG  SSGK+ +INA+L  +   S + H T CF+ +  +   K  ++ +             +E + + T N+   ++  +        V+VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S
Sbjct:   51 EDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGS-----------DEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKA-KCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDAS 242
[Close]
BLAST of Mitofusin 1 vs. TrEMBL
Match: A0A0N4W3T9 (Dynamin-type G domain-containing protein OS=Haemonchus placei OX=6290 GN=HPLM_LOCUS4498 PE=3 SV=2)

HSP 1 Score: 105.145 bits (261), Expect = 3.876e-19
Identity = 75/263 (28.52%), Postives = 136/263 (51.71%), Query Frame = 1 
Query:   67 SAQNNNKKMSQNIDSDARQEMR--KAKKLLTELENYIG-----FEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKI-IEEVEKI----STFNKETSSMSQES-VKVFIPIG---DDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCND--VSEEDERFFNIRINRTTKPDIFILVNKWDQS 801
            S  N + K S+ ++ DA   +R  +AKK+L ++   +G      +E+ K+  V     +  D      + +  I E   + N+K+ FFG  S+GK+  INA+L  +     M HTT CF+ +    +    ++H+      +  N+I I ++ KI    S+ N +  +M Q+S ++VF P G    +N++L+ +V ++DSPG     E    +  H  DAD+ + +L  +  +++ ++ FF     + +KP++FIL N+WD S
Sbjct:   13 SRHNLSLKNSRRMNGDAEPLLRFSEAKKVLGDIYTDLGKHVDELDEVYKDGSVSLVPAEQADEIALFRDSIKTIMETFRRDNMKVVFFGRTSNGKSTTINAMLHAKILPQGMGHTTCCFLQVQGCDEDNGYLLHE------DDPNRIPISQLGKIGHALSSDNSDLPAMGQDSLLRVFYPKGHGEGENRLLQNDVVILDSPGVDLSPEFDSWIDKHCLDADVFVLVLNAESTLTQAEKSFFYRVAKKLSKPNVFILNNRWDAS 269
[Close]
BLAST of Mitofusin 1 vs. TrEMBL
Match: A0A3P7JVE7 (Dynamin-type G domain-containing protein OS=Strongylus vulgaris OX=40348 GN=SVUK_LOCUS17882 PE=3 SV=1)

HSP 1 Score: 97.8265 bits (242), Expect = 1.475e-18
Identity = 62/190 (32.63%), Postives = 103/190 (54.21%), Query Frame = 1 
Query:  265 IQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMK-SPDAKYKIVHKNQEFIYESKNKIIEEVEK----ISTFNKETSSMSQES-VKVFIPIG---DDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCND--VSEEDERFFNIRINRTTKPDIFILVNKWDQS 801
            I E   + N+K+ FFG  S+GK+  INA+L  +     M HTT CF+ +   + D  Y ++  N E I       IE++ K    +S+ N    SM Q+S ++VF P G    +N++L+ +V ++DSPG     E    +  H  DAD+ + +L  +  +++ ++ FF     + +KP++FIL N+WD S
Sbjct:   73 IMETFRRDNMKVVFFGRTSNGKSTTINAMLHAKILPQGMGHTTCCFLQVQGCNEDTGYLLLEDNPERI------PIEQLSKMGHALSSDNSGLPSMGQDSLLRVFYPKGKGEGENRLLQNDVVILDSPGVDLSPEFDSWIDKHCLDADVFVLVLNAESTLTQAEKSFFYRVAKKLSKPNVFILNNRWDAS 256
[Close]
BLAST of Mitofusin 1 vs. TrEMBL
Match: A0A0N4T491 (Dynamin-type G domain-containing protein OS=Brugia pahangi OX=6280 GN=BPAG_LOCUS2991 PE=3 SV=1)

HSP 1 Score: 96.6709 bits (239), Expect = 9.850e-18
Identity = 61/205 (29.76%), Postives = 115/205 (56.10%), Query Frame = 1 
Query:  211 KIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKI----STFNKETSSMSQES-VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCN---DVSEEDERFFNIRINRTTKPDIFILVNKWDQS 801
            ++ +FKD        +  I++   +  +K+ FFG  S+GK+ +INA+L  +     M HTT CF+ +  SPD +  +++++      S+   IE+++K+    S  N   S+M Q+S + VF P    +++L+ +V ++DSPG     +    +  H  DAD+ + L+CN    +++ ++ FF+   ++ ++P+IFIL N+WD S
Sbjct:  109 EVARFKD-------SIKTIRDMFMRDTMKVVFFGRTSNGKSSVINAMLHAKVLPQGMGHTTCCFLQVEGSPDDQKFVLNED-----SSERMDIEQLQKLGHAMSDSNVSLSAMGQDSLLHVFYP-KSASRLLQNDVVIVDSPGVDLSPQFDSWIDKHCMDADVFV-LVCNAESTLTQAEKSFFHRVSSKLSRPNIFILNNRWDAS 299
[Close]
BLAST of Mitofusin 1 vs. TrEMBL
Match: F1KVN3 (Transmembrane GTPase fzo-1 OS=Ascaris suum OX=6253 PE=2 SV=1)

HSP 1 Score: 100.138 bits (248), Expect = 1.442e-17
Identity = 78/268 (29.10%), Postives = 137/268 (51.12%), Query Frame = 1 
Query:   67 SAQNNNKKMSQNIDSDARQEMRKAKK----LLTELENYIG-----FEELCKEWKVQ-----KKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHI-MKSPDAKYKIVHKNQEFIYESKNKIIEEVEKI----STFNKETSSMSQES-VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCN---DVSEEDERFFNIRINRTTKPDIFILVNKWDQS 801
            S  N + K S+ I S+  +   +AKK    +  +LE Y+      + E+     +      +++++F D        +  I+E   + N+K+ FFG  S+GK+ +INA+L  +     M HTT CF+ +   S + KY +   +       ++  I E+EK+    S  N    SM Q+S V+VF P    +++L+ +V ++DSPG     E    +  H  DAD+ + L+CN    +++ ++ FF+   ++ +KP+IFIL N+WD S
Sbjct:   12 SGDNRSGKPSRRIGSEPLKRFTEAKKAIGDIYNDLEGYVNDLSIFYHEVINGQNIVPDEQVREVERFMD-------SIKTIKEIFHRDNMKVVFFGRTSNGKSSVINAMLHSKVLPQGMGHTTCCFLQVEGGSENEKYLVCEDS------PRHHDISELEKLGHAMSANNAAMQSMGQDSLVRVFYP-KSASRLLQNDVVILDSPGVDLSPEFDSWIDKHCLDADVFV-LVCNAEATLTQAEKSFFHRVSSKLSKPNIFILNNRWDAS 264
[Close]
BLAST of Mitofusin 1 vs. TrEMBL
Match: A0A182EBZ9 (Dynamin-type G domain-containing protein OS=Onchocerca ochengi OX=42157 GN=NOO_LOCUS5589 PE=3 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 1.489e-17
Identity = 58/187 (31.02%), Postives = 110/187 (58.82%), Query Frame = 1 
Query:  265 IQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKI----STFNKETSSMSQES-VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCN---DVSEEDERFFNIRINRTTKPDIFILVNKWDQS 801
            I++   +  +K+ FFG  S+GK+ +INA+L  +     M HTT CF+ ++ SPD +  +++++      S+   IE+++++    S  N   S+M Q+S ++VF P    +++L+ +V ++DSPG     E    +  H  DAD+ + L+CN    +++ ++ FF+   ++ ++P+IFIL N+WD S
Sbjct:  100 IRDMFMRDTMKVVFFGRTSNGKSSVINAMLHAKVLPQGMGHTTCCFLQVVGSPDDQKFVLNEDS-----SERMDIEQLQRLGHAMSDNNVSLSAMGQDSLLRVFYP-KSASRLLQNDVVIVDSPGVDLSPEFDSWIDKHCMDADVFV-LVCNAESTLTQAEKSFFHRVSSKLSRPNIFILNNRWDAS 279
[Close]
BLAST of Mitofusin 1 vs. Ensembl Cavefish
Match: ENSAMXT00000043809.1 (mitofusin-1-like [Source:NCBI gene;Acc:103034819])

HSP 1 Score: 83.9593 bits (206), Expect = 5.316e-16
Identity = 60/198 (30.30%), Postives = 102/198 (51.52%), Query Frame = 1 
Query:  253 QLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQSDQDQD 816
            +L  I E ++++ +K+ FFG  S+GK+ +INA+L      S + HTT CF+ + +  D        +Q F+    +   EE + I T N+   ++  +        V+VF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S+ + +
Sbjct:   64 KLEAIWEVLARRQMKVAFFGRTSNGKSTVINAMLRERVLPSGIGHTTNCFISV-EGTDG-------DQAFLTTENS---EERKSIKTVNQLAHALHMDRNLDSGCLVRVFWP-KTKCALLRDDLVLMDSPGTDVTSELDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVSERISKPNIFILNNRWDASETEPE 248
[Close]
BLAST of Mitofusin 1 vs. Ensembl Cavefish
Match: mfn1b (mitofusin-1 [Source:NCBI gene;Acc:103030239])

HSP 1 Score: 82.8037 bits (203), Expect = 1.238e-15
Identity = 59/193 (30.57%), Postives = 100/193 (51.81%), Query Frame = 1 
Query:  253 QLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            +L  I+E ++++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  + + K  +           K +  EE + I T N+   ++  +        VKVF P      +L+ ++ L+DSPGT    +L   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S
Sbjct:   64 KLAVIKEVLARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDEDKAYL-----------KTEGSEEEKSIKTVNQLAHALHMDESLDAGCLVKVFWP-KTKCALLRDDLVLVDSPGTDVTTQLDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDAS 243
[Close]
BLAST of Mitofusin 1 vs. Ensembl Cavefish
Match: mfn1b (mitofusin-1 [Source:NCBI gene;Acc:103030239])

HSP 1 Score: 82.8037 bits (203), Expect = 1.240e-15
Identity = 59/193 (30.57%), Postives = 100/193 (51.81%), Query Frame = 1 
Query:  253 QLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            +L  I+E ++++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  + + K  +           K +  EE + I T N+   ++  +        VKVF P      +L+ ++ L+DSPGT    +L   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S
Sbjct:   64 KLAVIKEVLARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDEDKAYL-----------KTEGSEEEKSIKTVNQLAHALHMDESLDAGCLVKVFWP-KTKCALLRDDLVLVDSPGTDVTTQLDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDAS 243
[Close]
BLAST of Mitofusin 1 vs. Ensembl Cavefish
Match: mfn2 (mitofusin 2 [Source:ZFIN;Acc:ZDB-GENE-081105-44])

HSP 1 Score: 78.1814 bits (191), Expect = 3.596e-14
Identity = 57/194 (29.38%), Postives = 100/194 (51.55%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVS---EEDERFFNIRINRTTKPDIFILVNKWDQS 801
            +++  I E +S++++K+ FFG  S+GK+ +INA+L  +   S + HTT CF+ + +  D        N+ F+    +   EE + + T N+   ++ Q+        V V  P      +L+ ++ L+DSPG     EL   +     DAD+ + L+ N  S   + ++ FF+    R + P+IFIL N+WD S
Sbjct:   83 SKVAGIGEVLSRRHMKVVFFGRTSNGKSSVINAMLWDKVLPSGIGHTTNCFLRV-EGTDG-------NEAFLLTEGS---EERKNVKTVNQLAHALHQDEDLDAGSLVCVMWPKA-KCALLRDDLVLVDSPGIDVTTELDSWIDKFCLDADVFV-LVANSESTLMQTEKSFFHKVNERLSSPNIFILNNRWDAS 263
[Close]
BLAST of Mitofusin 1 vs. Ensembl Nematostella
Match: EDO42379 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1L1])

HSP 1 Score: 88.1965 bits (217), Expect = 1.159e-17
Identity = 72/240 (30.00%), Postives = 116/240 (48.33%), Query Frame = 1 
Query:  142 KLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQSDQDQDSRLCEL 834
            K L E   +I   E+ +++K    IK F         Q+  I E I++  +K+ FFG  S+GK+ ++NA+L        + HTT CF+ +  S  A   I+      I ES     +E   + T  +   ++ +E       V+V+ P     K+L  +V L+DSPG     +L   +  H  DAD+ + L+CN  S     ++ FF+    + +KP+IFIL N+WD S  + D  + EL
Sbjct:   48 KYLDEANRFICGCEIAEDYK--SNIKGFACDVAGFLGQVASITEVIARDQMKVAFFGRTSNGKSTVVNAMLQDRILPMGIGHTTNCFLSVNGSDSADPYIL------IPES-----DERRNVKTLGQIAHALFEEKLDHSSLVQVYWP-KSRCKMLSEDVVLVDSPGIDVSPDLDLWIDKHCLDADVFV-LVCNAESTLMVTEKNFFHKVNQKLSKPNIFILNNRWDASAGEPDVEMMEL 272
[Close]
BLAST of Mitofusin 1 vs. Ensembl Nematostella
Match: EDO49580 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGQ2])

HSP 1 Score: 51.6026 bits (122), Expect = 2.153e-6
Identity = 49/183 (26.78%), Postives = 82/183 (44.81%), Query Frame = 1 
Query:  271 EEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYE----SKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILK-GNVELIDSPGTGDIEELIECVQNHLSD-ADICIYLLCNDVS--EEDERFFNIRINRTTKPDIFILVNKWD 795
            EE   K   I   G  +SGK+ LIN +LGG +  +     T   V I  S +   ++   N E +       K +I  +   +    K + +   E V+  + +G +N +L+ G++EL+D+PG  + E L + VQ  +     + IY++  + S   +D  F      R     IF + NK D
Sbjct:   86 EEFVSKKAAILVVGQTNSGKSSLINELLGGTYLPTAEIPCTSRIVRICYSDNNYVEVQGPNGECVQGKQSFGKKRIPRDEIALDDDKKRSDA---EWVRCVVKVGLNNSLLRGGHLELVDAPGMSENEVLDQIVQECIHGILQVVIYVIDGNSSLRTQDREFLFSLKERIDSIPIFFVCNKVD 265
[Close]
BLAST of Mitofusin 1 vs. Ensembl Medaka
Match: mfn1b (mitofusin 1 [Source:NCBI gene;Acc:101158009])

HSP 1 Score: 82.4185 bits (202), Expect = 1.496e-15
Identity = 57/194 (29.38%), Postives = 101/194 (52.06%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            ++L  I+E ++++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  + D +  +           K +  +E + I T N+   ++  +        V+VF P      +L+ ++ L+DSPGT    +L   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S
Sbjct:   74 DKLAVIKEVLARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDDDRSYL-----------KTEGSDEEKSIKTVNQMAHALHMDESLDAGCLVRVFWP-KTKCALLRDDLVLVDSPGTDVTTQLDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDAS 254
[Close]
BLAST of Mitofusin 1 vs. Ensembl Medaka
Match: mfn1b (mitofusin 1 [Source:NCBI gene;Acc:101158009])

HSP 1 Score: 82.4185 bits (202), Expect = 1.545e-15
Identity = 57/194 (29.38%), Postives = 101/194 (52.06%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQS 801
            ++L  I+E ++++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  + D +  +           K +  +E + I T N+   ++  +        V+VF P      +L+ ++ L+DSPGT    +L   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S
Sbjct:   74 DKLAVIKEVLARRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDDDRSYL-----------KTEGSDEEKSIKTVNQMAHALHMDESLDAGCLVRVFWP-KTKCALLRDDLVLVDSPGTDVTTQLDSWIDKFCLDADVFV-LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDAS 254
[Close]
BLAST of Mitofusin 1 vs. Ensembl Medaka
Match: ENSORLT00000009003.2 (pep primary_assembly:ASM223467v1:17:11595384:11602171:-1 gene:ENSORLG00000007178.2 transcript:ENSORLT00000009003.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 79.337 bits (194), Expect = 3.033e-15
Identity = 59/199 (29.65%), Postives = 99/199 (49.75%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQES-------VKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSE---EDERFFNIRINRTTKPDIFILVNKWDQSDQDQD 816
             +L  I++ + ++++K+ FFG  S+GK+ +INA+L      S + HTT CF+ +  +   +  +  +             EE   IST N+   ++  +        VKVF P      +L+ ++ L+DSPGT    EL   +     DAD+ + L+ N  S     ++ FF+    R +KP+IFIL N+WD S  + D
Sbjct:   61 TKLYTIRDVLLRRHMKVAFFGRTSNGKSTVINAMLRDRVLPSGIGHTTNCFLSVEGTDGDEAYLTSEAS-----------EERRSISTVNQLAHALHMDPTLDSSCLVKVFWP-KSRCALLRNDLVLMDSPGTDVTLELDSWIDKFCLDADVFV-LVGNAESTLMNTEKLFFHKVSERISKPNIFILHNRWDASVTEPD 246
[Close]
BLAST of Mitofusin 1 vs. Ensembl Medaka
Match: mfn2 (mitofusin 2 [Source:NCBI gene;Acc:101170481])

HSP 1 Score: 75.8702 bits (185), Expect = 1.894e-13
Identity = 50/187 (26.74%), Postives = 99/187 (52.94%), Query Frame = 1 
Query:  250 NQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVS---EEDERFFNIRINRTTKPDIFILVNKWDQS 801
            +++  I E ++++++K+ FFG  S+GK+ +INA+L  +   S + HTT CF+ +  +  ++  ++ +  E     + K I+ V +++    +   +   S+   +       +L+ ++ L+DSPG     EL   +     DAD+ + L+ N  S   + ++ FF+    R + P+IFIL N+WD S
Sbjct:   83 SKVAGIGEVLARRHMKVVFFGRTSNGKSTVINAMLCDKVLPSGIGHTTNCFLRVEGTDGSEGFLLTEGSE-----EKKSIKTVNQLAHALHQDQDLDAGSLVCVMWPKVKCALLRDDLVLVDSPGIDVTTELDSWIDKFCLDADVFV-LVANSESTLMQTEKSFFHKVNERLSSPNIFILNNRWDAS 263
[Close]
BLAST of Mitofusin 1 vs. Planmine SMEST
Match: SMESG000070111.1 (SMESG000070111.1)

HSP 1 Score: 531.946 bits (1369), Expect = 0.000e+0
Identity = 262/262 (100.00%), Postives = 262/262 (100.00%), Query Frame = 1 
Query:   49 MISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQDSRLCEL 834
            MISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQDSRLCEL
Sbjct:    1 MISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQDSRLCEL 262
[Close]
BLAST of Mitofusin 1 vs. Planmine SMEST
Match: SMESG000070111.1 (SMESG000070111.1)

HSP 1 Score: 531.946 bits (1369), Expect = 5.422e-178
Identity = 261/261 (100.00%), Postives = 261/261 (100.00%), Query Frame = 1 
Query:   49 MISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQDSRLCE 831
            MISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQDSRLCE
Sbjct:    1 MISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQDSRLCE 261

HSP 2 Score: 431.795 bits (1109), Expect = 1.330e-139
Identity = 215/217 (99.08%), Postives = 216/217 (99.54%), Query Frame = 3 
Query: 1074 LLQTYKNLVGKCFGLVGKFGGPKTKDIDKRIIFISAIEVFGYRIKNKEPSNRNQKIRYADFERFEDQIEEYIQNPQQLKTRRYKREIKTLLKELNIIIVELSKQINNIDFESCVKRYEGYKTQALIFKEITRRDCEKLQLQCKENIECKVTKMLNTINIDNKEINEQITQHYDLINKSISDLFQELEREYSKLASDIESISVSDVTDQSNYENTLKQ 1724
            L +TYKNLVGKCFGLVGKFGGPKTKDIDKRIIFISAIEVFGYRIKNKEPSNRNQKIRYADFERFEDQIEEYIQNPQQLKTRRYKREIKTLLKELNIIIVELSKQINNIDFESCVKRYEGYKTQALIFKEITRRDCEKLQLQCKENIECKVTKMLNTINIDNKEINEQITQHYDLINKSISDLFQELEREYSKLASDIESISVSDVTDQSNYENTLKQ
Sbjct:  259 LCETYKNLVGKCFGLVGKFGGPKTKDIDKRIIFISAIEVFGYRIKNKEPSNRNQKIRYADFERFEDQIEEYIQNPQQLKTRRYKREIKTLLKELNIIIVELSKQINNIDFESCVKRYEGYKTQALIFKEITRRDCEKLQLQCKENIECKVTKMLNTINIDNKEINEQITQHYDLINKSISDLFQELEREYSKLASDIESISVSDVTDQSNYENTLKQ 475
[Close]
BLAST of Mitofusin 1 vs. Planmine SMEST
Match: SMESG000070111.1 (SMESG000070111.1)

HSP 1 Score: 279.256 bits (713), Expect = 1.238e-87
Identity = 137/137 (100.00%), Postives = 137/137 (100.00%), Query Frame = 1 
Query:   49 MISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQE 459
            MISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQE
Sbjct:    1 MISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQE 137
[Close]
BLAST of Mitofusin 1 vs. Planmine SMEST
Match: SMESG000014747.1 (SMESG000014747.1)

HSP 1 Score: 225.328 bits (573), Expect = 6.952e-63
Identity = 114/244 (46.72%), Postives = 170/244 (69.67%), Query Frame = 1 
Query:   91 MSQNIDSDARQEMRKAKKLLTELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSEEDERFFNIRINRTTKPDIFILVNKWDQSDQDQDSR 822
            M+QN   +   E+   K LLT+++N   + +L +E  V++ I +F     +L+ ++N  Q++  ++  KI+FFG +SSGK++LIN ILG + F+S + HTT CFVHI KS + KY+I H    FIY++K + +++VE IST N+ +     E V++FIP+G DNKILKGNVEL+DSPG+G   E+ EC++N+ +DA+I +Y+L +D++EEDERFF  +    TKPDIFIL NKWDQ DQD +S+
Sbjct:    1 MAQNYIENLSNEIDAFKLLLTKIQNNGEYSKLYEELNVKELIDRFTTECDKLQGKMNIFQKKFIREQRKIYFFGRMSSGKSKLINGILGEDLFLSAVKHTTNCFVHIRKSDNEKYRIRHGGDTFIYDNKKEAMDKVETISTVNEWSKFTENEFVELFIPLGKDNKILKGNVELVDSPGSGIRGEISECIRNYATDANIFVYVLSDDITEEDERFFEFQ-KTVTKPDIFILFNKWDQLDQDCESK 243

HSP 2 Score: 126.716 bits (317), Expect = 7.490e-30
Identity = 79/191 (41.36%), Postives = 109/191 (57.07%), Query Frame = 3 
Query: 1080 QTYKNLVGKCFGLVGKFGGPKTKDIDKRIIFISAIEVFGYRIKNKEPSNRNQKIRYADFERFEDQIEEYIQNPQQLKTRRYKREIKTLLKELNIIIVELSKQINNIDFESCVKRYEGYKTQALIFKEITRRDCEKLQLQCKENIECKVTKMLNTINIDNKEINEQITQHYDLINKSISDLFQELEREYSKL 1652
            +TYK L G+C  L+  F G +TKDIDKRI F+SA E+   RI  K+ +   +K RY +F  FE+ I EYIQN +  +  R   EI         ++ +L K+IN IDF+S V + E  K Q   F +  ++ CEK + +C E I+C VT MLNT   D K I  +I +HY  IN+S   L +EL  +Y  L
Sbjct:  247 KTYKALKGRCQNLIKTFMGKQTKDIDKRIYFVSAKELLDIRINKKDLNGSKEKERYEEFLHFENYISEYIQNYETSEICR--TEIDIERNNFKNLVEKLKKRINKIDFDSSVGKLEKDKMQTERFTKEIQKICEKFKSECNEKIKCNVTTMLNTTTFDKKIIQNKIAKHYFGINRSFRALIKELYEKYGSL 435

HSP 3 Score: 67.781 bits (164), Expect = 3.629e-11
Identity = 39/98 (39.80%), Postives = 60/98 (61.22%), Query Frame = 2 
Query: 3164 IAIRGLSFIPLISGIAANIHISRGNTKKETVNESLAELDREVHKSDDEKLRLVKEAIDKVKDNFTSKVDNLLKIIENKMQLQKEYKKYLLNLFQ*RNA 3457
            +A R LSFIP+ISG   N +I++  TK+ ++ E L E+D+ +H +DD KL++V + I  +K  FTSK   L+     ++ L+  YK YL + F   NA
Sbjct:  471 VATRFLSFIPIISGFITNAYINKMLTKEISI-EDLNEIDKTIHSNDDGKLKMVDDNISNIKFYFTSKAAALMDRQNREINLRNRYKNYLHDFFVRMNA 567
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BLAST of Mitofusin 1 vs. Planmine SMEST
Match: SMESG000014753.1 (SMESG000014753.1)

HSP 1 Score: 164.081 bits (414), Expect = 7.200e-42
Identity = 88/252 (34.92%), Postives = 157/252 (62.30%), Query Frame = 1 
Query:   91 MSQNIDSDARQEMRKAKKLLTELEN-----YIGFEEL---C----KEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKIFFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHKNQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGNVELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSEEDERFFNIRINRTTKPDIFILVNKWDQSDQD 810
            M+ +I  +  ++++  +K ++E+EN     Y    E+   C    +EWKV+K +  F  +   +E++   I E++++  +KIF FG VS GK++L+NA+LG  +F S   HTT  FVH+ KS D  Y+I  K+ +  +  K K IEE+E+IS   K   + + E+++V I + DD  +LK  +E++D PG+G+  ++ +C++ +  +ADI I++L   ++++D  FF  + + +TKPD+FI++N+WD+SD D
Sbjct:    1 MNISILPETLKQLKNIRKTVSEIENNDKINYGKISEINNKCDITEEEWKVKKTVLNFSSKLDNIESKYEVITEKVNRDVVKIFLFGKVSVGKSKLLNAMLGDNYFASGTAHTTSSFVHVKKSEDDSYRIKTKDTDRTFTDKTKFIEEIERISGDIKGNKATANETIEVSICM-DDETLLKKGIEIVDCPGSGNKSQITDCIKKNSQEADIFIFVLNYALTDDDRVFFKYQEDSSTKPDVFIVINQWDESDND 251

HSP 2 Score: 60.077 bits (144), Expect = 8.895e-9
Identity = 43/120 (35.83%), Postives = 61/120 (50.83%), Query Frame = 3 
Query: 1107 CFGLVGKFGGPKTKDIDKRIIFISAIEVFGYRIKNKEP---SNRNQKIRYADFERFEDQIEEYIQNPQQLKTRRYKREIKTLLKELNIIIVELSKQINNIDFESCVKRYEGYKTQALIFK 1457
            C   + K    K  +I  RI F SA E+   RI+N +    S+ N K R+ DF RFE  +++YI +PQ  KTRRY +EIK +   LN   ++    I N    S + +YE +      FK
Sbjct:  267 CSKFLRKLEITKEDEIYDRIYFFSAREMSQIRIENNDSLVDSDPNVKKRFEDFMRFEYNLKKYINDPQDNKTRRYMQEIKNIQDFLNTEFMKFQADIFNEKNNSLIPKYEKWMKDMEDFK 386
The following BLAST results are available for this feature:
BLAST of Mitofusin 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MFN15.610e-1629.27mitofusin 1 [Source:HGNC Symbol;Acc:HGNC:18262][more]
MFN12.374e-1529.27mitofusin 1 [Source:HGNC Symbol;Acc:HGNC:18262][more]
MFN12.374e-1529.27mitofusin 1 [Source:HGNC Symbol;Acc:HGNC:18262][more]
MFN25.977e-1428.87mitofusin 2 [Source:HGNC Symbol;Acc:HGNC:16877][more]
MFN25.977e-1428.87mitofusin 2 [Source:HGNC Symbol;Acc:HGNC:16877][more]
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BLAST of Mitofusin 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
fzo-18.764e-1626.24Transmembrane GTPase fzo-1 [Source:UniProtKB/Swis... [more]
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BLAST of Mitofusin 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
fzo9.510e-1726.16gene:FBgn0011596 transcript:FBtr0084399[more]
Marf1.018e-1527.50gene:FBgn0029870 transcript:FBtr0343373[more]
Marf2.188e-1527.32gene:FBgn0029870 transcript:FBtr0070910[more]
Marf2.188e-1527.32gene:FBgn0029870 transcript:FBtr0070909[more]
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BLAST of Mitofusin 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mfn1b3.382e-1731.22mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553... [more]
mfn1b4.453e-1731.22mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553... [more]
mfn1b1.455e-1631.22mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553... [more]
mfn1b1.529e-1631.22mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553... [more]
mfn1b1.529e-1631.22mitofusin 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1553... [more]
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BLAST of Mitofusin 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mfn13.982e-1629.52mitofusin 1 [Source:NCBI gene;Acc:548943][more]
mfn11.886e-1529.00mitofusin 1 [Source:NCBI gene;Acc:548943][more]
mfn11.913e-1529.00mitofusin 1 [Source:NCBI gene;Acc:548943][more]
mfn11.935e-1529.00mitofusin 1 [Source:NCBI gene;Acc:548943][more]
mfn12.084e-1529.15mitofusin 1 [Source:NCBI gene;Acc:548943][more]
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BLAST of Mitofusin 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Mfn15.267e-1629.70mitofusin 1 [Source:MGI Symbol;Acc:MGI:1914664][more]
Mfn19.920e-1629.52mitofusin 1 [Source:MGI Symbol;Acc:MGI:1914664][more]
Mfn19.920e-1629.52mitofusin 1 [Source:MGI Symbol;Acc:MGI:1914664][more]
Mfn21.036e-1428.35mitofusin 2 [Source:MGI Symbol;Acc:MGI:2442230][more]
Mfn21.036e-1428.35mitofusin 2 [Source:MGI Symbol;Acc:MGI:2442230][more]
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BLAST of Mitofusin 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O18412|FZO_DROME9.533e-1626.16Transmembrane GTPase fzo OS=Drosophila melanogaste... [more]
sp|Q8R4Z9|MFN1_RAT6.535e-1529.52Mitofusin-1 OS=Rattus norvegicus OX=10116 GN=Mfn1 ... [more]
sp|Q811U4|MFN1_MOUSE6.939e-1529.52Mitofusin-1 OS=Mus musculus OX=10090 GN=Mfn1 PE=1 ... [more]
sp|Q23424|FZO1_CAEEL1.115e-1426.24Transmembrane GTPase fzo-1 OS=Caenorhabditis elega... [more]
sp|Q8IWA4|MFN1_HUMAN1.140e-1429.27Mitofusin-1 OS=Homo sapiens OX=9606 GN=MFN1 PE=1 S... [more]
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BLAST of Mitofusin 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0N4W3T93.876e-1928.52Dynamin-type G domain-containing protein OS=Haemon... [more]
A0A3P7JVE71.475e-1832.63Dynamin-type G domain-containing protein OS=Strong... [more]
A0A0N4T4919.850e-1829.76Dynamin-type G domain-containing protein OS=Brugia... [more]
F1KVN31.442e-1729.10Transmembrane GTPase fzo-1 OS=Ascaris suum OX=6253... [more]
A0A182EBZ91.489e-1731.02Dynamin-type G domain-containing protein OS=Onchoc... [more]
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BLAST of Mitofusin 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSAMXT00000043809.15.316e-1630.30mitofusin-1-like [Source:NCBI gene;Acc:103034819][more]
mfn1b1.238e-1530.57mitofusin-1 [Source:NCBI gene;Acc:103030239][more]
mfn1b1.240e-1530.57mitofusin-1 [Source:NCBI gene;Acc:103030239][more]
mfn23.596e-1429.38mitofusin 2 [Source:ZFIN;Acc:ZDB-GENE-081105-44][more]
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BLAST of Mitofusin 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Mitofusin 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Mitofusin 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO423791.159e-1730.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO495802.153e-626.78Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Mitofusin 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
mfn1b1.496e-1529.38mitofusin 1 [Source:NCBI gene;Acc:101158009][more]
mfn1b1.545e-1529.38mitofusin 1 [Source:NCBI gene;Acc:101158009][more]
ENSORLT00000009003.23.033e-1529.65pep primary_assembly:ASM223467v1:17:11595384:11602... [more]
mfn21.894e-1326.74mitofusin 2 [Source:NCBI gene;Acc:101170481][more]
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BLAST of Mitofusin 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000070111.10.000e+0100.00SMESG000070111.1[more]
SMESG000070111.15.422e-178100.00SMESG000070111.1[more]
SMESG000070111.11.238e-87100.00SMESG000070111.1[more]
SMESG000014747.16.952e-6346.72SMESG000014747.1[more]
SMESG000014753.17.200e-4234.92SMESG000014753.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30017290 ID=SMED30017290|Name=Mitofusin 1|organism=Schmidtea mediterranea sexual|type=transcript|length=3507bp
CTAAAATTAGTCATAGCCTTCTCATTTACTTCCAAACTGGTACACTGCAT
GATTTCATTTGTTCAATCGGCACAAAATAACAATAAAAAAATGTCCCAAA
ATATCGATAGCGACGCCCGTCAAGAAATGAGAAAAGCCAAGAAATTATTA
ACAGAATTAGAAAATTATATAGGATTTGAAGAGCTTTGCAAAGAATGGAA
AGTTCAAAAAAAAATTAAGAAATTTAAGGATCGATTCGTGGAACTGGAGA
ATCAGTTGAATGATATTCAGGAGGAAATTAGCAAGAAGAATATAAAGATC
TTTTTTTTTGGAAGTGTATCATCTGGAAAAACCAGACTGATAAATGCAAT
CCTGGGAGGGGAGTTCTTTATGTCAACTATGAACCACACAACAAAATGTT
TTGTCCACATCATGAAATCTCCGGACGCCAAATACAAAATTGTTCATAAA
AATCAGGAATTTATTTATGAAAGTAAAAACAAAATCATTGAAGAAGTAGA
AAAGATTTCAACATTTAATAAAGAGACTTCATCAATGAGCCAAGAATCTG
TGAAGGTGTTTATCCCTATTGGGGATGATAATAAGATCTTGAAAGGAAAT
GTAGAATTGATTGACTCTCCTGGCACCGGAGACATAGAGGAACTGATAGA
ATGCGTTCAGAATCATTTGTCTGATGCGGATATTTGCATATATCTTTTAT
GCAATGACGTCAGTGAGGAGGATGAAAGGTTTTTCAACATCCGCATTAAT
CGGACAACAAAACCGGATATTTTCATTTTGGTCAACAAATGGGATCAGTC
AGATCAGGATCAGGATAGTCGATTATGCGAACTCTGATGGAGGCCGCATG
GGGGCATCAAGGTCAGGGTCCTCCCCCATGCTAGATAACTTTATTTACCA
AATGGCTCGTGTGCTGACAAATGTTCAATTAACCTTCTTACTATTTTATT
TCAGTTTTTTCCGGACCAAAACATATTGGCTATATTAAAAATAAGTGATT
TCGCTAATAATAATAAATTACAAAATATTTTCCCATATATTTATACGCCA
CCAAATATTTACATTATATCTATCTATTGCAGACTTACAAAAATCTCGTA
GGCAAATGCTTTGGACTGGTTGGAAAATTTGGGGGCCCCAAAACAAAAGA
TATTGACAAAAGAATTATATTTATATCTGCCATAGAGGTTTTTGGCTACA
GGATAAAAAATAAGGAGCCTTCCAATCGAAATCAAAAAATAAGATATGCA
GATTTCGAACGGTTTGAAGACCAGATTGAAGAATACATTCAGAATCCACA
ACAACTCAAAACCCGCCGCTACAAACGTGAAATTAAAACATTATTAAAGG
AGTTGAATATAATTATTGTTGAATTATCAAAGCAAATTAACAACATTGAC
TTTGAATCGTGCGTCAAACGCTATGAAGGCTACAAAACGCAAGCTTTAAT
ATTTAAAGAAATAACTCGAAGAGACTGTGAGAAATTGCAGTTGCAGTGCA
AGGAGAACATTGAATGCAAAGTCACAAAAATGTTAAATACGATAAACATT
GATAATAAAGAAATAAACGAACAAATTACGCAGCATTACGATCTTATAAA
CAAATCTATTTCTGATTTATTTCAAGAATTAGAAAGGGAATATAGCAAGC
TGGCCAGTGACATTGAAAGTATAAGCGTCTCTGATGTCACAGACCAATCG
AATTATGAAAATACATTAAAACAAGTAAGTTAAAACACATTGCAATGATT
TAAATCACAAACAATTTCACTTATAAATAAATTTTTGAGATATATTTTGA
CAAAAACTGCCGTTTTTAAATTATAATTTTCAAAAATATTTATTTTTACA
AAAAATGTGGTTTTTCGTAAAATAATATTAAATAATTTTAATTTACGCAA
AATCAAAGCGCTTTTAATTAACTAAAAGGCATCAAGATTTCTAGTTTAAA
GACCTTGCTGCGTATCCTCAGTCACAAACAACTTTATCTGAACTCAGTGA
ATTAGAATAGGCACCAAGGACCACCAGTTGTATAGTTTCAAATAACTAAA
GTCGCTGATACAAAAAGATGAAGATAAAACAATTTGGGTGGAAAATAATG
AAAGTCTGACAAACGAGTAATGAATTATGTGCCATATGGCCCAATTTTTT
GTACTCCGTTACTACTTATTAATTAATAAATATTTCGTATTTTTGTAATT
ATTAATTATTTAAATTCAATTTATTTATTTCTATTTAAATTAAACTTTGC
TTTATTAATTTTTAATTACTCTGTTTATTTATTATTTAATTATTTTTATT
ATTATACATTTTTTAATTTAAAATAATGTCACTGGTAGACAGCATACGCC
AAGGGCAAATTTATTTTAAAAGTACATTTAAACTAAGACAATGAGTCATA
GGTCAAAGGTCATATTTTTCAAGGTTAAATATTTTTTAGGTAAAATATTA
TTATTATTACAATTGCTATATAATTGAAAAAATCATAAATAAAACTTTTA
TTAATTAGATACAATTATACTAAAATGATAGTGACAAAGCTGTAATCAAA
GTTTATCGATTATTATATCTCTGATATCGAGCAGTGCAGCAGCTGCATCC
ATAAATGCACGGACATTCAAGCATTCAATGCTGCTGTCTTGCTTCTCTAG
AACTGTAGACTTTCTTTTATAATTACAAAATATTTATACAAAAACCTTTT
AAAAAATAATAATAGTTATTTATCGCAGTGATAGATATCGAATTCACTCA
TTATTTGAACTACACTCGGAATTCCGTACATTTAAAAAAACAGCTAGTTC
AATGGCAATTCGTATATTTGTTTAAATGGTTTCCTTTTTATTAAAGATTG
CCAAATTTTATTGTCAACTTGAAAGTCCTTATGAAGGTTAATTCAAATAA
GTCAGTTTCAGTTTTGATTAAAAATCAAGGTGACCCCTAAAATGTAAGTG
GAATAAATCATTAAATATAAACACTTAAAATGATATTTGATATTTTTTCA
AAATAAAAATAAATGAATTCGTAAAATTATATTGTTTATGAATTTGTTAA
TTTCAGAAGATTTCGGTAGAGGTAAGTTATGTAATTATATATATATATAT
ATGTAAATGATTTTTATAATTTACAGGTTGAACCTAGATGAACATCCACT
TCCATTGTCAAGAATTGCTATTAGAGGCCTATCTTTTATTCCTCTTATCA
GTGGCATTGCTGCAAATATACATATAAGTAGAGGTAATACGAAAAAGGAA
ACAGTTAACGAATCACTTGCTGAATTGGATCGAGAAGTCCATAAAAGCGA
TGATGAAAAATTGAGACTGGTCAAGGAGGCCATTGACAAAGTTAAAGATA
ATTTTACATCAAAAGTGGACAATTTATTGAAAATAATTGAAAATAAAATG
CAACTGCAAAAAGAATATAAAAAATATTTGCTTAATTTGTTTCAATGAAG
AAATGCATTGCGGACATTTTAAATTTGGTCTGGAGGAACTTTTGTTTTAA
TTTTATT
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protein sequence of SMED30017290-orf-1

>SMED30017290-orf-1 ID=SMED30017290-orf-1|Name=SMED30017290-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=279bp
LKLVIAFSFTSKLVHCMISFVQSAQNNNKKMSQNIDSDARQEMRKAKKLL
TELENYIGFEELCKEWKVQKKIKKFKDRFVELENQLNDIQEEISKKNIKI
FFFGSVSSGKTRLINAILGGEFFMSTMNHTTKCFVHIMKSPDAKYKIVHK
NQEFIYESKNKIIEEVEKISTFNKETSSMSQESVKVFIPIGDDNKILKGN
VELIDSPGTGDIEELIECVQNHLSDADICIYLLCNDVSEEDERFFNIRIN
RTTKPDIFILVNKWDQSDQDQDSRLCEL*
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protein sequence of SMED30017290-orf-2

>SMED30017290-orf-2 ID=SMED30017290-orf-2|Name=SMED30017290-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=114bp
MIFIIYRLNLDEHPLPLSRIAIRGLSFIPLISGIAANIHISRGNTKKETV
NESLAELDREVHKSDDEKLRLVKEAIDKVKDNFTSKVDNLLKIIENKMQL
QKEYKKYLLNLFQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005739mitochondrion
GO:0031307integral component of mitochondrial outer membrane
GO:0098799outer mitochondrial membrane protein complex
GO:0005741mitochondrial outer membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0010918positive regulation of mitochondrial membrane potential
GO:0046039GTP metabolic process
GO:0051646mitochondrion localization
GO:1990613mitochondrial membrane fusion
GO:0008053mitochondrial fusion
Vocabulary: molecular function
TermDefinition
GO:0042802identical protein binding
GO:0005525GTP binding
GO:0003924GTPase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR027094Mitofusin_fam
IPR027417P-loop_NTPase
IPR022812Dynamin_SF
IPR030381G_DYNAMIN_dom
IPR014010REJ_dom
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 21..41
NoneNo IPR availableCOILSCoilCoilcoord: 72..99
NoneNo IPR availableGENE3DG3DSA:3.40.50.300coord: 100..277
e-value: 5.1E-24
score: 87.1
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..16
score: 0.492
IPR022812Dynamin superfamilyPFAMPF00350Dynamin_Ncoord: 100..259
e-value: 2.1E-17
score: 63.7
IPR027094Mitofusin familyPANTHERPTHR10465TRANSMEMBRANE GTPASE FZO1coord: 61..271
IPR030381Dynamin-type guanine nucleotide-binding (G) domainPROSITEPS51718G_DYNAMIN_2coord: 94..278
score: 16.432
IPR027417P-loop containing nucleoside triphosphate hydrolaseSUPERFAMILYSSF52540P-loop containing nucleoside triphosphate hydrolasescoord: 77..271