COP9 signalosome complex subunit 3

Overview
NameCOP9 signalosome complex subunit 3
Smed IDSMED30017252
Length (bp)1364
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of COP9 signalosome complex subunit 3 (SMED30017252) t-SNE clustered cells

Violin plots show distribution of expression levels for COP9 signalosome complex subunit 3 (SMED30017252) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of COP9 signalosome complex subunit 3 (SMED30017252) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for COP9 signalosome complex subunit 3 (SMED30017252) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30017252

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30017252h1SMcG0018970 SmedASXL_006960SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Human
Match: COPS3 (COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239])

HSP 1 Score: 184.882 bits (468), Expect = 6.354e-53
Identity = 114/407 (28.01%), Postives = 225/407 (55.28%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N+ +Q S    ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+     +    P +++++  +        Y E    ++T + S+L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ +++F +N E  ++  +L  + ++M  C++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI--LLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Human
Match: COPS3 (COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239])

HSP 1 Score: 179.874 bits (455), Expect = 3.194e-51
Identity = 109/390 (27.95%), Postives = 217/390 (55.64%), Query Frame = 1 
Query:   88 VSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+     +    P +++++  +        Y E    ++T + S+L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ +++F +N E  ++  +L  + ++M  C++L   ++ ++ +++++  +++K
Sbjct:    1 MTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI--LLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQK 386
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Human
Match: COPS3 (COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239])

HSP 1 Score: 117.857 bits (294), Expect = 3.646e-29
Identity = 72/232 (31.03%), Postives = 131/232 (56.47%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLL 723
            A+  F N+ +Q S    ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+
Sbjct:    4 ALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI 233
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Human
Match: COPS3 (COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239])

HSP 1 Score: 113.235 bits (282), Expect = 2.895e-27
Identity = 67/215 (31.16%), Postives = 123/215 (57.21%), Query Frame = 1 
Query:   88 VSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLL 723
            ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+
Sbjct:    1 MTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI 213
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Celegans
Match: csn-3 (COP9 signalosome complex subunit 3 [Source:UniProtKB/Swiss-Prot;Acc:Q9N425])

HSP 1 Score: 49.6766 bits (117), Expect = 3.227e-6
Identity = 39/174 (22.41%), Postives = 85/174 (48.85%), Query Frame = 1 
Query:  574 FYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFD--RNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKID 1086
            + Y G  + + +K FE A +  E+C+  P  ++     ++ KK+ L++L L G  D   N DK   SA    + K      + E   + ++ +HS +  + ++ +     D N  + K  +   +++ I+ LT+++ S+ +SE+  +  L S ++  +++  ++    I  +ID
Sbjct:  262 YLYNGACILIELKRFEDALFLLEICVGMPAFSVQDQHLDSFKKYVLISLILKGKVDVTENGDK---SAIRHFKTKSPEYKQFSEIRFSRSSNTHSAVESLVKSAKDRLRKDGNTEIAKYLVVEMKKKTIMSLTRMFTSIRISEIEELAFLKSRDQVTELIGQLVEEQRITVRID 432
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Fly
Match: CSN3 (gene:FBgn0027055 transcript:FBtr0078269)

HSP 1 Score: 136.732 bits (343), Expect = 3.012e-35
Identity = 118/426 (27.70%), Postives = 209/426 (49.06%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEIC----KKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHKSV------------------DAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+ N+ N  +  S   +  E+A  L E+  L   + S LD +L+ LD++++S+   +V   K+   S   PE   L+  + +F+      Q+R    Y +    E C    + + Q +    GI  I   +++ ++   +LTPIH +L  L+L  K F  ++  +D DI D+                      DA  +  ++Y+GGM+Y AVKN+ERA YFFE+C+  P   ++ I+ E +KKF +++L+       I  P  +  + R +K M    Y + +  +   S  +L  I   +   F  D N GL KQ      +R I +LTK +++LSLS++   ++L S  E E+ + +MI    I A I+QK+ ++ F ++ E  +S ++   +Q  +   +     I K+ +++ L+  Y+KK
Sbjct:    4 ALENYVNQVRTLSASGSYRELAEELPESLSLLARNWSILDNVLETLDMQQHSLGVLYVLLAKLHSASTANPEPVQLIQLMRDFVQRNNNEQLR----YAVCAFYETCHLFTEFVVQKNLSILGIRIISRAIDQIRQLETQLTPIHADLCLLSLKAKNFSVVLPYLDADITDISTVAAECKTQQQQQSQHADANNDAKYFLLYFYYGGMIYTAVKNYERALYFFEVCITTPAMAMSHIMLEAYKKFLMVSLIVEGKIAYI--PKNTQVIGRFMKPMAN-HYHDLVNVYANSSSEELRIIILKYSEAFTRDNNMGLAKQVATSLYKRNIQRLTKTFLTLSLSDVASRVQLASAVEAERYILNMIKSGEIYASINQKDGMVLFKDDPEKYNSPEMFLNVQNNITHVLDQVRQINKMEEEIILNPMYVKK 422
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Zebrafish
Match: cops3 (COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239])

HSP 1 Score: 138.658 bits (348), Expect = 5.506e-36
Identity = 106/411 (25.79%), Postives = 217/411 (52.80%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARL-DRQLKDM--FKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N  +Q S    ++++  L++++ +L   +LS+LD +L  LD++E+S+    V + K S   P++P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT +H +L QL L  K F   +  ++ D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YFFE  +  P   ++ I+ E +KK+ L++L L+G   +    P +++++  R +K +  FK      +   N  S+  L    +    L   D    + K  L ++ E+ +  LT+ ++S+S +++  ++ L   +       S I    I A I+QK+ ++ F +N E  ++  +L K+ ++M  C++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNNVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDIQEHSLGVLAVLFVKFSM--PNIPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGISILKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPAVPFLELDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFFEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQ---LPKYTSQIVGRFIKKLINFKHHLENIVKTQNINSYRNLYFPKQLTTEL--RDQKIYICKHVLYFNYEKNLKTLTENFLSISKNDVENVVCLCVFQHLRCFSLSQIEDGEIYASINQKDGMVCFHDNPEKYNNPAMLHKIDQEMLKCIELDEKLKSMDQEITVNPQFVQK 407
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Xenopus
Match: cops3 (COP9 signalosome subunit 3 [Source:NCBI gene;Acc:549992])

HSP 1 Score: 183.341 bits (464), Expect = 2.038e-52
Identity = 115/408 (28.19%), Postives = 226/408 (55.39%), Query Frame = 1 
Query:   46 AINNFCNAFKQRSN---VSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N+ +Q S+   ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL+L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E +KK+ L++L L+G   +    P +++++  +        Y E    ++T + ++L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ ++ F +N E  ++  +L  + ++M  C+ L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNSVRQLSSQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSIPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGICVLRQAIDKMQMNANQLTSIHADLCQLSLLAKCFKPALAYLDVDMMDICKENGAYDAKPFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQ---LPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPAELRNLVSKHNETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGAQEAEKYVLYMIEDGEIFASINQKDGMVCFHDNPEKYNNPAMLHNIDQEMLRCIDLDDRLKAMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Xenopus
Match: cops3 (COP9 signalosome subunit 3 [Source:NCBI gene;Acc:549992])

HSP 1 Score: 171.4 bits (433), Expect = 9.606e-48
Identity = 119/438 (27.17%), Postives = 230/438 (52.51%), Query Frame = 1 
Query:   46 AINNFCNAFKQRSN---VSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIR-----TYYKY---------------------YLNMIQEICKKIPQCSFQ----FKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N+ +Q S+   ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR       Y Y                      L+ +  +C ++     +     +GI  +   ++K Q +  +LT IH +L QL+L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E +KK+ L++L L+G   +    P +++++  +        Y E    ++T + ++L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ ++ F +N E  ++  +L  + ++M  C+ L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNSVRQLSSQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSIPDFETLFSQVQLFISTCNGEHIRYATDTCEYAYGRCRGFSSDCNKLLTMFLCFFVLSPVAGLCHQLTNALVERKQPLRGICVLRQAIDKMQMNANQLTSIHADLCQLSLLAKCFKPALAYLDVDMMDICKENGAYDAKPFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQ---LPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPAELRNLVSKHNETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGAQEAEKYVLYMIEDGEIFASINQKDGMVCFHDNPEKYNNPAMLHNIDQEMLRCIDLDDRLKAMDQEITVNPQFVQK 436
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Xenopus
Match: cops3 (COP9 signalosome subunit 3 [Source:NCBI gene;Acc:549992])

HSP 1 Score: 152.525 bits (384), Expect = 2.708e-41
Identity = 106/391 (27.11%), Postives = 206/391 (52.69%), Query Frame = 1 
Query:   88 VSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL+L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E +KK+ L++L L+G   +    P +++++  +        Y E    ++T + ++L  +   H   F  D N GL+KQCL    ++ I +LTK  V+L    +     L   E+ E           I A I+QK+ ++ F +N E  ++  +L  + ++M  C+ L   ++ ++ +++++  +++K
Sbjct:    1 MTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSIPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGICVLRQAIDKMQMNANQLTSIHADLCQLSLLAKCFKPALAYLDVDMMDICKENGAYDAKPFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQ---LPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPAELRNLVSKHNETFTRDNNMGLVKQCLSSLYKKNIQRLTK--VNLGCCAVISSFFLPQIEDGE-----------IFASINQKDGMVCFHDNPEKYNNPAMLHNIDQEMLRCIDLDDRLKAMDQEITVNPQFVQK 373
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Xenopus
Match: cops3 (COP9 signalosome subunit 3 [Source:NCBI gene;Acc:549992])

HSP 1 Score: 129.413 bits (324), Expect = 3.863e-33
Identity = 97/391 (24.81%), Postives = 187/391 (47.83%), Query Frame = 1 
Query:   88 VSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL+L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E +KK+ L++L L+G                +QL        G FI  F                                               ++LSL ++   ++L+  +E EK +  MI    I A I+QK+ ++ F +N E  ++  +L  + ++M  C+ L   ++ ++ +++++  +++K
Sbjct:    1 MTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSIPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGICVLRQAIDKMQMNANQLTSIHADLCQLSLLAKCFKPALAYLDVDMMDICKENGAYDAKPFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLEAYKKYILVSLILHGKV--------------QQLPKYTSQIVGRFIKTF-----------------------------------------------LTLSLQDMASRVQLSGAQEAEKYVLYMIEDGEIFASINQKDGMVCFHDNPEKYNNPAMLHNIDQEMLRCIDLDDRLKAMDQEITVNPQFVQK 328
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Mouse
Match: Cops3 (COP9 signalosome subunit 3 [Source:MGI Symbol;Acc:MGI:1349409])

HSP 1 Score: 184.882 bits (468), Expect = 4.228e-53
Identity = 113/407 (27.76%), Postives = 225/407 (55.28%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N+ +Q S    ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT +H +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+     +    P +++++  +        Y E    ++T + S+L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ +++F +N E  ++  +L  + ++M  C++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI--LLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVSKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Mouse
Match: Cops3 (COP9 signalosome subunit 3 [Source:MGI Symbol;Acc:MGI:1349409])

HSP 1 Score: 97.8265 bits (242), Expect = 7.950e-23
Identity = 77/277 (27.80%), Postives = 133/277 (48.01%), Query Frame = 1 
Query:  172 LDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSE 993
            LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR    Y  +    +C ++     + K                           QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+     +    P +++++  +        Y E    ++T + S+L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL +
Sbjct:    3 LDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIR----YATDTFAGLCHQLTNALVERK---------------------------QLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI--LLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVSKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQD 244
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. UniProt/SwissProt
Match: sp|A6H7B5|CSN3_BOVIN (COP9 signalosome complex subunit 3 OS=Bos taurus OX=9913 GN=COPS3 PE=2 SV=1)

HSP 1 Score: 186.808 bits (473), Expect = 5.438e-53
Identity = 113/407 (27.76%), Postives = 226/407 (55.53%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N+ +Q S    ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT +H +L QL L  K F   +  +D D++D+ K   + DA  +  +YY+GGMVY  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+     +    P +++++  +        Y E    ++T + S+L  +   H  +F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ +++F +N E  ++  +L  + ++M  C++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGVLRQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMVDICKENGAYDAKHFLCYYYYGGMVYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI--LLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRSLVTKHSEIFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. UniProt/SwissProt
Match: sp|O88543|CSN3_MOUSE (COP9 signalosome complex subunit 3 OS=Mus musculus OX=10090 GN=Cops3 PE=1 SV=3)

HSP 1 Score: 184.882 bits (468), Expect = 2.957e-52
Identity = 113/407 (27.76%), Postives = 225/407 (55.28%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N+ +Q S    ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT +H +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+     +    P +++++  +        Y E    ++T + S+L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ +++F +N E  ++  +L  + ++M  C++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI--LLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVSKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. UniProt/SwissProt
Match: sp|Q5RFS2|CSN3_PONAB (COP9 signalosome complex subunit 3 OS=Pongo abelii OX=9601 GN=COPS3 PE=2 SV=1)

HSP 1 Score: 184.882 bits (468), Expect = 3.051e-52
Identity = 114/407 (28.01%), Postives = 225/407 (55.28%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N+ +Q S    ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+     +    P +++++  +        Y E    ++T + S+L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ +++F +N E  ++  +L  + ++M  C++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI--LLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. UniProt/SwissProt
Match: sp|Q4R898|CSN3_MACFA (COP9 signalosome complex subunit 3 OS=Macaca fascicularis OX=9541 GN=COPS3 PE=2 SV=1)

HSP 1 Score: 184.882 bits (468), Expect = 3.051e-52
Identity = 114/407 (28.01%), Postives = 225/407 (55.28%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N+ +Q S    ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+     +    P +++++  +        Y E    ++T + S+L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ +++F +N E  ++  +L  + ++M  C++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI--LLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. UniProt/SwissProt
Match: sp|Q9UNS2|CSN3_HUMAN (COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3)

HSP 1 Score: 184.882 bits (468), Expect = 3.051e-52
Identity = 114/407 (28.01%), Postives = 225/407 (55.28%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N+ +Q S    ++++  L++++ +L   +LS+LD +L  LDV+E+S+    V + K S   P +P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  +   ++K Q +  +LT IH +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YF+E  +  P   ++ I+ E++KK+ L++L+     +    P +++++  +        Y E    ++T + S+L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ +++F +N E  ++  +L  + ++M  C++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSM--PSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLI--LLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. TrEMBL
Match: C3YWE6 (PCI domain-containing protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_275202 PE=4 SV=1)

HSP 1 Score: 207.994 bits (528), Expect = 1.517e-58
Identity = 122/402 (30.35%), Postives = 226/402 (56.22%), Query Frame = 1 
Query:   55 NFCNAFKQRSNVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            N   A     N+ E+  L++++ D+ + +  NLD  L  LD++E+S+    +   K +  SP LP+F  L +++  FI  C   QIR     + N+  +    + +     +GI  +   + K Q    +LT +H +L QL L +K     +  +D DI D+ K   + D   + S+YY+GGM+Y A+KN++RA YFFE+ +  P   ++ I+ E++KK+ L++L L+G   + +  P +++++  +        Y + + A+NT +  +L  + + HR +F+ +  YGL+KQCL    ++ I +LTK +++LSL+++   ++L+  +E EK +  MI    I A IDQK  ++NF +N E  D+  +LQ L E+M+ CM L   ++K++ +++++  Y++K
Sbjct:   10 NQVRALSSSGNLRELCDLINKSGDILQKNAPNLDTALGALDIQEHSLGVLAILCVKFT-ISP-LPDFEGLFSQVELFIAACNGEQIRFATDSFANLCHQFSHALVERKMSIRGINPLCHAIQKVQLHPAQLTSVHGDLCQLCLLSKCMKPALPFLDTDITDISKESGAFDTKHFLSYYYYGGMIYTALKNYDRALYFFEVAVTTPAMAVSHIMLESYKKYVLVSLILHG---KVLQLPKYTSQVVTRFIKPLSQAYHDLVTAYNTNNPQELRSMVDKHRDVFQRENTYGLVKQCLASIYKKNIQRLTKTFLTLSLADMANRVQLSGPKEAEKYVLEMIEDGEIYATIDQKEGMVNFRDNPEKYDNPAMLQYLDEEMKKCMGLDEQLRKMDQEIAVNPQYVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. TrEMBL
Match: Q5D9V1 (SJCHGC02823 protein OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 203.756 bits (517), Expect = 5.291e-57
Identity = 138/420 (32.86%), Postives = 233/420 (55.48%), Query Frame = 1 
Query:   46 AINNFCNAF-KQRSNVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHK-ISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHKS---VDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKKLVEKEMASMK*VA 1287
            +++NF +A  K   +V+ +  L++++ D    ++ +LD +L + D+ ++ I+HA V + K ISQ+  D  E+  L+ +   F   CC   ++    Y   +  E    +       KGI  +I  + K QK   +LTP+H +L QLAL  K F   + V+D DI+++ +S   ++A  Y  ++Y+GGM+Y AVKN+ER+ +FFELCL  P  + + I+ E  KK  L++L L+G F    + P+      R  K  +   Y E   AF + +  +L    + HR LF  D N+GL+KQ LK H +  I  LTK +++LSL ++   ++L+  +E EK +  MI    I A IDQ++  ++F ++ E  DS+ +LQ LQ+K+  C+ L+    +L D++  + NY K+++E E  + K V 
Sbjct:    5 SLSNFSSAVNKTGGSVNALYELIEKSQDFLMRNVHSLDSILDDFDIAKFGILHAAVIHVKYISQSVVD-KEW--LIIQTQNFFNYCCPESLQKVPSYVRIISHEFTNCLINMEVPHKGISCMITAIRKLQKCLGQLTPLHCDLCQLALAAKMFSPTLSVLDTDILEIEQSGTALEAKDYLLYFYYGGMIYGAVKNWERSLHFFELCLIIPAVSSSCILIEAAKKIILISLILHGKFSTVPETPVAYFMSPRPWK-CYCQPYLELATAFRSNNPDELIAFVDLHRELFTADFNFGLVKQVLKCHVKFRIQSLTKTFITLSLIDVAIHIKLSGTQEAEKHILDMIKSRAIFANIDQESGTVHFLDDPEQYDSMKMLQILQQKITECINLEKHFMQLTDRLMTNPNYAKRMIELETKTTKSVG 420
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. TrEMBL
Match: A0A074ZXF7 (PCI domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_11448 PE=4 SV=1)

HSP 1 Score: 196.823 bits (499), Expect = 3.000e-54
Identity = 129/431 (29.93%), Postives = 233/431 (54.06%), Query Frame = 1 
Query:   46 AINNFCNAFKQRSNVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHK-ISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHKSVDAACYES----------------FYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLL-NGHFDRNIDKP--LFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKKLVEKEMASMK 1278
            A+N    AF Q      +  L++++++L   H SNLD +    D+ +Y+ +HA +   K +SQ S D      L+ +   F   C  +  R   +Y   + QE   ++   +  F+GIE+++ G+ K Q+   +LT +H+++ QLAL  + F  ++ +++ DI+++ K+V    + S                ++Y+GGM+Y A+KN+ERA +FFELCL  P+ +++ I+ E  KK  L +L+ NG F   +  P    S R  ++    +   Y     AF   +   L  + ETHR  F  D NYGL+KQ  K + +  I  LTK ++++SL+++   ++L + +E EK L  MI    I A+IDQ+N  + F ++ E  +S+++   LQ+K+E C+ L+  +  ++D+++ +  Y+K+++E E  + K
Sbjct:   12 AVNKTGGAFNQ------LKELVEKSNELLLRHASNLDSIFDSYDIDKYTCLHAGILRAKYLSQLSLDR---EVLILQTQSFFEQCSVDDARKMSQYVRTISQEFTNRLIAWNVAFRGIESLMIGIKKLQRSPSQLTSLHSDVCQLALSARLFSPVLPLLNVDILEIEKNVGKRSFNSLLHRQYSFVDQKDYLLYFYYGGMIYGALKNWERALHFFELCLIIPSFSVSCILVEAAKKVILTSLIYNGKFTTVLKVPTQFVSPRPWKR----YCQPYMALATAFQDPNPEALETVIETHRNTFVADHNYGLVKQVAKSYVKFRIHSLTKTFMTMSLADVASRVKLANAQEAEKYLLEMIESKAIFARIDQRNGTVYFQDDPERYNSMEMFMTLQKKIEECVALEKYLMNISDELTENPKYVKRMLELESRTAK 429
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. TrEMBL
Match: A0A5K4FDN4 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 193.356 bits (490), Expect = 4.794e-53
Identity = 128/417 (30.70%), Postives = 228/417 (54.68%), Query Frame = 1 
Query:   46 AINNFCNAF-KQRSNVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHK-ISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHKS---VDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKKLVEKEMASMK 1278
            +++NF +A  K   + + +  L++++ +    ++ +LD +L + D+ ++ I+HA V + K ISQ+  D  E+  L+ +       C    ++    Y   +  E    +       KGI  ++  ++K QK    LTP+H +L QL L  + F   + ++D +I+++ KS   ++A  Y  ++Y+GGM+Y AVKN+ER+ +FFELCL  P  + + I+ E  KK  L++L L+G F   ++ P       R  K  +   Y E   AF + +   L    + HR LF  D N+GL+KQ +K H +  I  LTK +++LSL+++   ++L+  +E EK +  MI    I A IDQ++  ++F ++ E  DS+ +L+ LQEK+  C+ L+    +L D++  + NY K+++E E  + K
Sbjct:    5 SLSNFSSAVNKTAGSANALCELVEKSQEFLIRNVHSLDFILDDFDIAKFGILHAAVIHAKYISQSVVD-KEW--LVIQTQNLFNLCNSESLQKIPSYVRVISHEFTNCLINMGIPHKGISCMVTAIHKLQKCPGYLTPLHCDLCQLGLAARMFSPTLSILDINILEIDKSSTALEAKDYLLYFYYGGMIYGAVKNWERSLHFFELCLIIPAVSSSCILIEAAKKIILISLILHGKFSTVLETPAAYFMSPRPWK-CYCQPYLELATAFRSNNPEDLTNFVDLHRELFTADFNFGLVKQVIKCHGKFRIQSLTKTFMTLSLTDVAMRIKLSGTQEAEKQILDMIKSKAIFANIDQQSGTVHFLDDPEQYDSIKMLRILQEKITECVNLEKHFMQLTDRLVTNPNYAKRMIELETKAAK 417
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. TrEMBL
Match: A0A5A9PT63 (COP9 signalosome complex subunit 3 OS=Triplophysa tibetana OX=1572043 GN=E1301_Tti010425 PE=4 SV=1)

HSP 1 Score: 190.66 bits (483), Expect = 4.632e-52
Identity = 117/408 (28.68%), Postives = 226/408 (55.39%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N  +Q S    ++++  L++++ +L   +LS+LD +L  LD++E+S+    V + K S   P++P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  I   ++K Q +  +LT +H +L QL L  K F   +  ++ D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YFFE  +  P   ++ I+ E +KK+ L++L L+G   +    P +++++  +        Y E    + T S + L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+ ++E EK +  MI    I A I+QK+ ++ F +N E  ++  +L K+ ++M TC++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNNVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDIQEHSLGVLAVLFVKFSM--PNIPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGISVIKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPAVLFLELDMMDICKENGAYDAKPFLCYYYYGGMIYTGLKNFERALYFFEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQ---LPKYTSQIVGRFIKPLSNAYHELAQVYATNSPADLRALVNKHSETFTRDNNTGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGSQEAEKYVLHMIEDGEIYASINQKDGMVCFHDNPEKYNNPAMLHKIDQEMLTCIELDEKLKSMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Cavefish
Match: cops3 (COP9 signalosome subunit 3 [Source:NCBI gene;Acc:103031635])

HSP 1 Score: 185.652 bits (470), Expect = 1.581e-53
Identity = 116/408 (28.43%), Postives = 224/408 (54.90%), Query Frame = 1 
Query:   46 AINNFCNAFKQRS---NVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
            A+  F N  +Q S    ++++  L++++ +L   +LS+LD +L  LD++E+S+    V + K S   P++P+F  L +++  FI+ C    IR     +  +  ++   + +     +GI  I   + K Q +  +LT IH +L QL L  K F   +  ++ D+MD+ K   + DA  +  +YY+GGM+Y  +KNFERA YFFE  +  P   ++ I+ E +KK+ L++L L+G   +    P +++++  +        Y E    + T + ++L  +   H   F  D N GL+KQCL    ++ I +LTK +++LSL ++   ++L+  +E EK +  MI    I A I+QK+ ++ F +N E  ++  +L K+ ++M  C++L   ++ ++ +++++  +++K
Sbjct:    4 ALEQFVNNVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDIQEHSLGVLAVLFVKFSM--PNIPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGIIKQAIEKMQMNTNQLTSIHADLCQLCLLAKCFKPAVPFLELDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFFEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQ---LPKYTSQIVGRFIKPLSNAYHELAQVYATNNPAELRNVVNKHSETFTRDNNTGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIYASINQKDGMVCFHDNPEKYNNPAMLHKIDQEMLKCIELDEKLKSMDQEITVNPQFVQK 406
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Sea Lamprey
Match: cops3 (COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc:HGNC:2239])

HSP 1 Score: 155.606 bits (392), Expect = 5.169e-43
Identity = 109/411 (26.52%), Postives = 219/411 (53.28%), Query Frame = 1 
Query:   46 AINNFCNAFKQRSN---VSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHK---SVDAACYESFYYFGGMVYLAVKNFERAQYFFELC---LFNPTNNINRIIKETHKKFSLLTL-LNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKK 1248
             +  F N  +Q S+   ++++  L++++ +L   ++++LD +L  LDV+E+S+    V Y KIS   P++P+F  L +++  FI  C    IR     +  +   +   + +     +GI  +   ++K Q    +LT IH +L QL L  K F   +  +D D+MD+ K   + DA  +  +YY+GGM+Y  +KNF    Y    C   +  P   ++ I+ E++KK+ +++L L+G   + +  P +++++  +        Y E   A+ T + ++L      H   F ND N GL+KQC+    ++ I +LTK +++LSL ++   ++L+   E EK +  MI    I A I+QK+ ++ F +N E  ++  +L  + ++M+  ++L   ++ ++ +++++  +++K
Sbjct:    4 GLEQFVNNVRQLSSQGQMTQLCDLINKSVELLAKNVTHLDTVLGALDVQEHSLGVLAVLYVKISM--PNVPDFETLFSQVQLFIGACNGEHIRFATDSFAGLCHMLTNALVERKQALRGISILRQAIDKMQMSATQLTSIHADLCQLCLLAKCFKPALPYLDTDMMDICKENGAFDAKHFLCYYYYGGMIYTGLKNF--FCYPLARCNQAITTPAMAVSHIMLESYKKYIVVSLILHG---KVLALPKYTSQIVGRFIKPLSSAYHELAQAYATNNPAELRGTVAKHSETFANDSNMGLVKQCVCSLYKKNIQRLTKTFLTLSLQDMANRVQLSGPREAEKYVLHMIEDGEIFASINQKDGMVCFHDNPEKYNNPAMLLYIDQEMQKVIELDEKLRAMDQEITINPQFVQK 407
[Close]
BLAST of COP9 signalosome complex subunit 3 vs. Planmine SMEST
Match: SMESG000027201.1 (SMESG000027201.1)

HSP 1 Score: 813.913 bits (2101), Expect = 0.000e+0
Identity = 411/413 (99.52%), Postives = 413/413 (100.00%), Query Frame = 1 
Query:   40 MLAINNFCNAFKQRSNVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFTKYFXXXXXXXXXXXXXLHKSVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKKLVEKEMASMK 1278
            MLAINNFCNAFKQRSNVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLAL+TKYFDEIIEVIDEDIMDLHKSVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQI+NFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKKLVEKEMASMK
Sbjct:    1 MLAINNFCNAFKQRSNVSEVAALLDETSDLFRTHLSNLDILLQELDVKEYSIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLNMIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALYTKYFDEIIEVIDEDIMDLHKSVDAACYESFYYFGGMVYLAVKNFERAQYFFELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLKDMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHREREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQKNQIVNFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANYLKKLVEKEMASMK 413
The following BLAST results are available for this feature:
BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
COPS36.354e-5328.01COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc... [more]
COPS33.194e-5127.95COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc... [more]
COPS33.646e-2931.03COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc... [more]
COPS32.895e-2731.16COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc... [more]
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
csn-33.227e-622.41COP9 signalosome complex subunit 3 [Source:UniPro... [more]
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CSN33.012e-3527.70gene:FBgn0027055 transcript:FBtr0078269[more]
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cops35.506e-3625.79COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc... [more]
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cops32.038e-5228.19COP9 signalosome subunit 3 [Source:NCBI gene;Acc:5... [more]
cops39.606e-4827.17COP9 signalosome subunit 3 [Source:NCBI gene;Acc:5... [more]
cops32.708e-4127.11COP9 signalosome subunit 3 [Source:NCBI gene;Acc:5... [more]
cops33.863e-3324.81COP9 signalosome subunit 3 [Source:NCBI gene;Acc:5... [more]
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Cops34.228e-5327.76COP9 signalosome subunit 3 [Source:MGI Symbol;Acc:... [more]
Cops37.950e-2327.80COP9 signalosome subunit 3 [Source:MGI Symbol;Acc:... [more]
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BLAST of COP9 signalosome complex subunit 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|A6H7B5|CSN3_BOVIN5.438e-5327.76COP9 signalosome complex subunit 3 OS=Bos taurus O... [more]
sp|O88543|CSN3_MOUSE2.957e-5227.76COP9 signalosome complex subunit 3 OS=Mus musculus... [more]
sp|Q5RFS2|CSN3_PONAB3.051e-5228.01COP9 signalosome complex subunit 3 OS=Pongo abelii... [more]
sp|Q4R898|CSN3_MACFA3.051e-5228.01COP9 signalosome complex subunit 3 OS=Macaca fasci... [more]
sp|Q9UNS2|CSN3_HUMAN3.051e-5228.01COP9 signalosome complex subunit 3 OS=Homo sapiens... [more]
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BLAST of COP9 signalosome complex subunit 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
C3YWE61.517e-5830.35PCI domain-containing protein OS=Branchiostoma flo... [more]
Q5D9V15.291e-5732.86SJCHGC02823 protein OS=Schistosoma japonicum OX=61... [more]
A0A074ZXF73.000e-5429.93PCI domain-containing protein OS=Opisthorchis vive... [more]
A0A5K4FDN44.794e-5330.70Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A5A9PT634.632e-5228.68COP9 signalosome complex subunit 3 OS=Triplophysa ... [more]
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cops31.581e-5328.43COP9 signalosome subunit 3 [Source:NCBI gene;Acc:1... [more]
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cops35.169e-4326.52COP9 signalosome subunit 3 [Source:HGNC Symbol;Acc... [more]
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of COP9 signalosome complex subunit 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of COP9 signalosome complex subunit 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000027201.10.000e+099.52SMESG000027201.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30017252 ID=SMED30017252|Name=COP9 signalosome complex subunit 3|organism=Schmidtea mediterranea sexual|type=transcript|length=1364bp
TTTTTTATTAATTAACTAACCAAAAACTATTTTGAAAATATGCTTGCCAT
TAATAACTTTTGCAATGCTTTTAAACAGAGAAGCAATGTTTCAGAAGTCG
CTGCCTTGCTTGATGAAACTTCTGATTTATTTCGTACACATTTATCAAAT
TTAGACATTCTTTTACAGGAATTAGATGTTAAAGAATATTCTATAGTTCA
TGCTCATGTTTTTTATCACAAAATCAGTCAAACATCTCCAGATTTACCTG
AATTTAATGACTTATTAAATAAGATTAATGAATTTATTACTGGATGTTGT
AAAAATCAAATTAGAACTTATTATAAATACTATCTAAATATGATCCAAGA
AATCTGCAAAAAAATACCTCAGTGTAGTTTTCAATTTAAGGGAATCGAAA
CTATAATTGCAGGATTGAATAAATTCCAAAAAGACAATAAAGAATTGACA
CCGATTCATAATAATTTAGTCCAATTGGCACTTTTCACAAAATATTTCGA
TGAAATTATTGAAGTTATCGATGAAGATATCATGGATTTGCATAAAAGTG
TCGATGCTGCTTGTTATGAATCGTTTTACTATTTCGGTGGAATGGTTTAT
CTCGCCGTTAAAAATTTTGAACGAGCTCAATATTTCTTTGAATTGTGTCT
GTTCAATCCAACCAATAATATCAACAGAATTATTAAGGAAACTCACAAGA
AGTTTTCCTTATTAACTCTCCTGAACGGCCATTTCGATCGAAATATAGAC
AAACCGTTGTTTAGTGCTCGATTGGATCGGCAGTTGAAGGACATGTTTAA
AATGACTTACGGAGAATTCATTCTAGCATTCAACACGAAATCTCATTCTA
AGCTCTGTGAAATAGCAGAAACCCATCGGGGTCTGTTTGAGAATGATCTC
AATTACGGTCTCATTAAGCAATGTCTCAAATGGCATCGGGAAAGGGAGAT
TCTTAAACTGACAAAAGTTTACGTTTCTCTCAGTTTAAGTGAGCTCACCG
GGATTCTCGAATTGACCAGCAATGAAGAAACGGAAAAAATTCTATTTTCA
ATGATATCGAGGAGCATTATTGATGCGAAAATTGACCAGAAAAACCAAAT
TATAAATTTCAGTGAAAATTATGAGAGTTCCGATTCGGTGGATATTTTAC
AAAAACTGCAAGAAAAGATGGAAACTTGCATGAAATTGCAAGTCGGTATT
CAAAAGCTGAATGACAAAATGTCTCTCGACGCTAATTATTTGAAAAAGCT
GGTGGAGAAGGAAATGGCCAGTATGAAATGAGTTGCAACTTTACGGAGAA
CATTTTAACCAAAATTATATTTTCATTGTCGTTTTATAAATAAATTTATT
GAAAGTCTTTTAAA
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protein sequence of SMED30017252-orf-1

>SMED30017252-orf-1 ID=SMED30017252-orf-1|Name=SMED30017252-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=414bp
MLAINNFCNAFKQRSNVSEVAALLDETSDLFRTHLSNLDILLQELDVKEY
SIVHAHVFYHKISQTSPDLPEFNDLLNKINEFITGCCKNQIRTYYKYYLN
MIQEICKKIPQCSFQFKGIETIIAGLNKFQKDNKELTPIHNNLVQLALFT
KYFDEIIEVIDEDIMDLHKSVDAACYESFYYFGGMVYLAVKNFERAQYFF
ELCLFNPTNNINRIIKETHKKFSLLTLLNGHFDRNIDKPLFSARLDRQLK
DMFKMTYGEFILAFNTKSHSKLCEIAETHRGLFENDLNYGLIKQCLKWHR
EREILKLTKVYVSLSLSELTGILELTSNEETEKILFSMISRSIIDAKIDQ
KNQIINFSENYESSDSVDILQKLQEKMETCMKLQVGIQKLNDKMSLDANY
LKKLVEKEMASMK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR036388WH-like_DNA-bd_sf
IPR037753CSN3
IPR036390WH_DNA-bd_sf
IPR000717PCI_dom
IPR011991WHTH_DNA-bd_dom
IPR001678MeTrfase_RsmB/NOP2
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0008168methyltransferase activity
Vocabulary: biological process
TermDefinition
GO:0000338protein deneddylation
GO:0001701in utero embryonic development
GO:0006511ubiquitin-dependent protein catabolic process
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005737cytoplasm
GO:0005829cytosol
GO:0008180COP9 signalosome
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000717Proteasome component (PCI) domainSMARTSM00088PINT_4coord: 290..380
e-value: 2.8E-14
score: 63.4
IPR000717Proteasome component (PCI) domainPFAMPF01399PCIcoord: 259..359
e-value: 1.8E-14
score: 54.1
IPR000717Proteasome component (PCI) domainPROSITEPS50250PCIcoord: 192..362
score: 17.038
NoneNo IPR availableSMARTSM00753PINTcoord: 290..380
e-value: 2.8E-14
score: 63.4
NoneNo IPR availableGENE3DG3DSA:1.25.40.570coord: 173..302
e-value: 9.0E-25
score: 89.2
NoneNo IPR availablePANTHERPTHR1075826S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3coord: 14..406
IPR036388Winged helix-like DNA-binding domain superfamilyGENE3DG3DSA:1.10.10.10coord: 303..367
e-value: 7.2E-9
score: 37.1
IPR037753COP9 signalosome complex subunit 3PANTHERPTHR10758:SF1COP9 SIGNALOSOME COMPLEX SUBUNIT 3coord: 14..406
IPR036390Winged helix DNA-binding domain superfamilySUPERFAMILYSSF46785"Winged helix" DNA-binding domaincoord: 291..364