Guanylate cyclase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017219 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 13
Homology
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943]) HSP 1 Score: 756.903 bits (1953), Expect = 0.000e+0 Identity = 440/1085 (40.55%), Postives = 643/1085 (59.26%), Query Frame = 2
Query: 215 QIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSM-----SKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQD-ANFKIAK-EIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS-------QSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVK-----QKSKSLGSQDVSRFVVAFHDSVLIYAHALNDCL--DKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSN-IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
++ PAV++A ++K + + + TV + ++ + + +DL + P V LGP + A R + +RVPLLT G ALG K ++ + T ++ L + A+ W+ ++ LY + D F+ E ++ ++D N + E + L+ ++ LR + + R+I +C+ P+ R +M A + G DY F DI +S +RPW ++ ++A+++ IIT P++ + F +++K Q + ++ V+ +FHD +L+Y A+ + L V+DG++IT++M N+S G++G + IDS+GDR D+SL DMDP+ F+VV NG+ ++ V+ +++W PP D PKCGF N D CN L+ + + L+ +VS IYR + EL + W + W+ +E + ++E H + L + R SN+ SL T G QF Q+F+KT YK +VA+K + + K+IE+ + +L ++K ++D+ N+H+ RF+GAC +P ++CIL+EYCP+GSLQD+LEN+ I LDW+F++SL DI +GM++LH+ I HGNLKSSNC++D RFV+K+TD+GL+ R L E + Y LWTAPE+LR ++ V G+ GD+YSF IILQEI R+GVF++ + + P+EI+ERV + Q PFRP L +S H E+ ++++ W E P +RP + I++ RKFN+ +S NILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD++++N+DVYKVETIGDAY+VVSGLP RNG LHA E++RM+LA L A+ +F+I HR +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIH+S T VL+ FG F + RG +E+KGKG TYWL GE
Sbjct: 54 RVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDL-KWEHNPAVFLGPGCVYAAAPVGRFT-AHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALM---LYAY-RPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLS----HYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWE---RGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPL--GYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPS------------------------------------------SLERHLRSAGSRLTL--------SGRGSNY--GSLLTTEG-QF------QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR----DLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLD--LSPKEIIERVTRGEQPPFRPSLALQS--HLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054
BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR2 (natriuretic peptide receptor 2 [Source:HGNC Symbol;Acc:HGNC:7944]) HSP 1 Score: 717.227 bits (1850), Expect = 0.000e+0 Identity = 430/1096 (39.23%), Postives = 618/1096 (56.39%), Query Frame = 2
Query: 182 QNNLGNLPTLDQIVPAVDIAFEKIKQKF---IRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQD-FQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRE-LSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS-------QSQRPWYSPLNSTQEN-EILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKS-----LGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
++NL ++ PAV +A E + + +RF + EL +S +DL + P ++LGP + A+ R + +R+PLLT G A G K D ++ L T + L ++ + F W R+ L D D+ F E V++ LQ +N + ++Y AR P + + N RI+ +C E++ +I+ A GDY F D+ +S + RPW N T+E + L++A++++L+IT P + ++ F + +++ LG ++ F+D +L+YA LN+ + + + DG I E+M+ + +G++G V +D N DR D+ L M D + FQ A +G++K+ I WV PP D P C F D C+ ++ + I+ V S +I+R EL +M W I W+ E +F Y +G R L S SL T G +Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RFIGAC++P ++CI++EYCP+GSLQD+LEND I LDW+F++SLI D+ +GM +LH S I HG+LKSSNC++DSRFV+K+TD+GL R + + ++ +A Y LWTAPE+L + G K D+YSF IILQEI R+G FYL + + P+EIV++V+ ++ FRP + + N E+ ++++ W + P +RP+ IK R+FNK G + +ILDNLL RMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG HA EI+RM+LA L A+ +F+I HR +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQA+KIH+S T D L G F + RG +E+KGKG TYWL GE
Sbjct: 33 EHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELEGACSEYLAPLSA-----VDL-KLYHDPDLLLGPGCVYPAASVARFAS-HWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVY-----AREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQD--NRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGR-PIPWVK--GAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWE-------------------------------------------ELQFGNSERY---------HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLD--LSPKEIVQKVRNGQRPYFRPSIDRTQLNE--ELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2F (guanylate cyclase 2F, retinal [Source:HGNC Symbol;Acc:HGNC:4691]) HSP 1 Score: 455.292 bits (1170), Expect = 1.479e-140 Identity = 305/884 (34.50%), Postives = 468/884 (52.94%), Query Frame = 2
Query: 782 RIIILCAKPEVI-----RDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKS--KSLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVSDG-DHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD-CNFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIM-----HTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFG-SFIITERGQIELKGKGFQTTYWLHGE 3388
RIII+C +I +++ A+DL G Y F+ +D L S + ++P + N L++AY ++L IT+ E +++F+E + + L VS ++S+ A A+N+ + +N G + + +N +G + + DSNG+ ++Y +LD + K V+ + + I + RPP KC F+ C+ G F + L + L+ + +R+ NK++L + N+++ E+ +N F + + +VQ S R+ R ++S SL +EN S +Y+ V +K K I+ S + ++ K DL +++I +G + I++E+C +GSL+D+L N +KLDW+FK SL+ D+ +GM YLH HG LKS NC++D RFV+K+TD+G + + L + LLWTAPE+LR G+ GD+YSFAII+QE++ R F + + + QEI+ R+K+ E+ E ++KQ W E QRP I F+ FNK G NI+D++L +EQY++NLE L+ +RTE+ EK+K E LL MLP SVA L + V E ++ VT+YFSDIVGFT++SA S P++V++LLN LYT FD+I+ ++DVYKVETIGDAY+V SGLP+RNG+ HA EI+ MSL L ++ TF++ H + + +RIG+HSGPV AGVVGL MPRYCLFGDTVNTASRMES G +IH+S +T+ +L+ + + RG+ ELKGKG + T+WL G+
Sbjct: 243 RIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYK--HTPYRVLRNNPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHSTYTVD-MEMELLRFGGTPIHF--PGGRPPRADAKCWFAEGKICHGGIDPA----------------------FAMMVCLTLLIALLSINGFAYFIRRRI----NKIQLIK-GPNRILL-TLEDVTFINPHFGSKRGSRASVSFQITSEVQ-----SGRSPRL--SFSSGSLTPAT---YEN-------SNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMK--DLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDIL---EMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMD----LPAQEIINRLKKPPP---VYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNK-GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGK 1063
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2D (guanylate cyclase 2D, retinal [Source:HGNC Symbol;Acc:HGNC:4689]) HSP 1 Score: 431.024 bits (1107), Expect = 1.582e-131 Identity = 243/575 (42.26%), Postives = 356/575 (61.91%), Query Frame = 2
Query: 1712 NHYLMTNKDVQLFQ--GGSFRNARRLSNWSENSLETLAGIQFENLRN----HQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIG----------ACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGS-FIITERGQIELKGKGFQTTYWLHG 3385
N ++T D+ GG+ R ++ S +L ++R+ H GVY+ V +K + I I + K+++L ++++ ++G A L ++ ++SE+C +GSLQD+L +IKLDW+FK SL+ D+ +G+ YLH HG LKS NC++D RFV+K+TD G +L ++ +L E P A + LWTAPE+LR+ GT+ GD++S AII+QE++ R+ + + E + P+E+V+RV+ + RP + + E ++KQ W E P RP M + +F+ NK G NI+D++L +EQY++NLE L+ +RTE+ EK+K + LL MLP SVA L PV E +E VT+YFSDIVGFT++SA S P++V++LLN LYT FD+I+ ++DVYKVETIGDAY+V SGLPQRNG HA EI+ MSL L A+ TF++ H + + +RIG+HSGP AGVVGL MPRYCLFGDTVNTASRMES G +IH++ +T+ +L+ S + + RG+ ELKGKG + T+WL G
Sbjct: 501 NKIILTVDDITFLHPHGGTSRKV------AQGSRSSLGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQ-KVLPEPPRA--EDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLE----LTPEEVVQRVRSPPPL-CRPLVSMDQAP--VECILLMKQCWAEQPELRPSMDHTFDLFKNINK-GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058
BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2C (guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:4688]) HSP 1 Score: 391.734 bits (1005), Expect = 2.748e-117 Identity = 228/503 (45.33%), Postives = 313/503 (62.23%), Query Frame = 2
Query: 1916 KKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIK------LDWIFKFSLIQDICRGMIYLHSN-IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQI-PFRPYLGKES-ENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRK-FNKAGDSGN--ILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLK-TFGSFIITERGQIELKGKGFQTTYWLHG 3385
+KIE+NK L I D N + +F G + + EYC +GSL++VL ND I +DW FK S++ DI +GM YLHS+ HG LKS+NC++DSR VVK+TDFG + K L WTAPE LR +N + KGD+YS+ II QEII R FY + E + RV+ + PFRP L E+ E E+ ++K WEE P +RP+ + I+ K F D N +D L+ R++ Y+ NLE LV +RT+ Y E+ +A+ L +++LP+ V + L V E YE VTIYFSDIVGFT++ STPM+V+++LN +Y +FD I++++DVYKVETIGDAY+V SGLP+RNGN HA +I++M+L L + TF++ H + +RIG+HSGP AGVVG+KMPRYCLFGDTVNTASRMES G ++IH+S +T+ +LK T F+ RG+ LKG+G +TTYWL G
Sbjct: 529 QKIELNKLLQI------DYYN--LTKFYGTVKLDTMIFGVIEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDL-------------WTAPEHLRQANI----SQKGDVYSYGIIAQEIILRKETFYTLSCR---DRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 570.852 bits (1470), Expect = 0.000e+0 Identity = 285/545 (52.29%), Postives = 397/545 (72.84%), Query Frame = 2
Query: 1793 SENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKK---IEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEE-NPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQ---FRQIPFRPYLGKESENHGSEI--DSIIKQM---WEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHG 3385
S S+ET+A N Q+++KT ++K +VAIK + + KK ++++++ L+++KK+KDL +DHI RF GAC++ H C+++EYCPKGSL+D+LEN++I+LD + K+SL+ D+ +G+ +LH S I HG LKSSNC++DSRFV+K+TDFGL +L ++ LEE +A+Y+ +LWTAPE+LR+SN+ GT KGDIYSFAIIL E+++R GVF L + + P EIV+RV++ Q P RP++ + E G + D+++ M W E P +RPE+ +++ R N+ ++ N++DNLL RMEQYANNLEGLV +RT++YL EK+K E+LL+ +LP ++A LI V AESY+ VTIYFSDIVGFTSLS++STPMQV+ LLN LY FD +++N+ VYKVETIGDAY+VVSGLP+R + HA +I++MSL+ L + F I HR +L +RIGMHSG V AGVVG KMPRYCLFGDTVNT+SRMESNG +KIH+S+ T D+L F + RG +E+KGKG QTTYWL G
Sbjct: 727 SGGSVETIAQ------NNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENED--LSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1262 HSP 2 Score: 184.882 bits (468), Expect = 4.157e-47 Identity = 158/546 (28.94%), Postives = 258/546 (47.25%), Query Frame = 2
Query: 149 VIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNST-----------RPQVILGPLDDFNIANAVRLSDG-RYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQ---DLKYVLLAMFDE------------------FKWKPRSYKNV------------------GLYIFDMENDNNLGDFISEVVYKTLQ---DANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFH-KGDYAFISFDILNKSQSQRPWYSPLNST-QENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKS------KSLGSQD--VSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDC-NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKR 1585
VI I+ + S+ +N G TL + +P +DIA Q+ I+ + + T S L+E I L + R ILG D++ +A +++ G +P+LT G L K+++ LT +++ D Y L+A DE + K R+ V LY F E T Q D + I +E +KQ L RE+S S +IILCA P+ +R+IM AA+DLG G+Y FI+ D+ S +++PW ++ +ENE K+AYR+L I+L + + +K+F VK+++ ++ +D ++ F+ AF+D+VL+YA ALN+ + + +G +IT +M ++ GI+GNV ID NGDR +DYSLLD+DP F VA +G+ + V Q+ W V +PP D P CG+ + C + + L +++++ + I +R +K EL AM+W I W+ ++ E +
Sbjct: 43 VIVILPKRESTYDNFGM--TLQKAMPVIDIAV----QEVIKAKKLPPGWINLTYWDS---RLYEDILLAERHATVGVIQAYCEHRLDAILGFADNYGLATVTKVTAGLNGGIPILTTSGMPSLLNSKKEYPFLTRMQGSYRLLADSMYQLIAYHDEDSVSKSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSSHCYFSLYAIKRYFTEKSKTFKREWALNTPQFPFDEDLVIERETFKQWL-----------REISLQSNVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVG--QLHW--VGGKPPTDLPICGYDKSKCPGYPLHVYLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 564
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 570.466 bits (1469), Expect = 0.000e+0 Identity = 285/545 (52.29%), Postives = 397/545 (72.84%), Query Frame = 2
Query: 1793 SENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKK---IEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEE-NPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQ---FRQIPFRPYLGKESENHGSEI--DSIIKQM---WEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHG 3385
S S+ET+A N Q+++KT ++K +VAIK + + KK ++++++ L+++KK+KDL +DHI RF GAC++ H C+++EYCPKGSL+D+LEN++I+LD + K+SL+ D+ +G+ +LH S I HG LKSSNC++DSRFV+K+TDFGL +L ++ LEE +A+Y+ +LWTAPE+LR+SN+ GT KGDIYSFAIIL E+++R GVF L + + P EIV+RV++ Q P RP++ + E G + D+++ M W E P +RPE+ +++ R N+ ++ N++DNLL RMEQYANNLEGLV +RT++YL EK+K E+LL+ +LP ++A LI V AESY+ VTIYFSDIVGFTSLS++STPMQV+ LLN LY FD +++N+ VYKVETIGDAY+VVSGLP+R + HA +I++MSL+ L + F I HR +L +RIGMHSG V AGVVG KMPRYCLFGDTVNT+SRMESNG +KIH+S+ T D+L F + RG +E+KGKG QTTYWL G
Sbjct: 668 SGGSVETIAQ------NNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENED--LSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1203 HSP 2 Score: 180.259 bits (456), Expect = 1.015e-45 Identity = 147/510 (28.82%), Postives = 257/510 (50.39%), Query Frame = 2
Query: 146 MVIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQ-KFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSD--GRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWK-------------PRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFH-KGDYAFISFDILNKSQSQRPWYSPLNST-QENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKS------KSLGSQD--VSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFAXXXXXXXXXXXXXXXXXXXXXY--RHFKFHIELKAMNWLIMWDCIETTEKR 1585
+V+G+ +E N L TL + P D+A + + + + + + ++ L+ ++ ++I+ N T I+G + +A R+S G+ VP+ T L + +F +LT + +++ L ++ + + F+W+ PR+ Y F + NL ++ N K+ E +L R L E S S +IILCA P+ +R+IM AA+DLG G+Y FI+ D+ S +++PW ++ +ENE K+AYR+L I+L + + +K+F VK+++ ++ +D ++ F+ AF+D+VL+YA ALN+ + + +G +IT +M ++ GI+GNV ID NGDR +DYSLLD+DP F VA +G+ + V Q+ W V +PP D P CG+ + C G+ L + ++ L+I +V + I+ R +K EL AM+W I W+ ++ E +
Sbjct: 30 IVVGLPIEEGDRGKN-PFLLTLAKSKPVFDVALQDVYHLRILPYGSLKVTFENSALSDAVGPQ--KMIEHYCNKTV-DAIMGLPYVYALAPVARISKFWGQ-GVPVFTTTALVDELGDRNEFPLLTRMMGSYKSLGKLVTRIAERFEWQHYFFMFNDEVARGPRNKGRSECY-FSLSAIKNL------IMNNKTSTWNVKMFSEFEADRLQYRAL-----LSEASVMSNLIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVG--QLHW--VGGKPPTDLPICGYDKSKCPQGYPLHVYLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 518
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 570.081 bits (1468), Expect = 0.000e+0 Identity = 285/545 (52.29%), Postives = 397/545 (72.84%), Query Frame = 2
Query: 1793 SENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKK---IEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEE-NPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQ---FRQIPFRPYLGKESENHGSEI--DSIIKQM---WEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHG 3385
S S+ET+A N Q+++KT ++K +VAIK + + KK ++++++ L+++KK+KDL +DHI RF GAC++ H C+++EYCPKGSL+D+LEN++I+LD + K+SL+ D+ +G+ +LH S I HG LKSSNC++DSRFV+K+TDFGL +L ++ LEE +A+Y+ +LWTAPE+LR+SN+ GT KGDIYSFAIIL E+++R GVF L + + P EIV+RV++ Q P RP++ + E G + D+++ M W E P +RPE+ +++ R N+ ++ N++DNLL RMEQYANNLEGLV +RT++YL EK+K E+LL+ +LP ++A LI V AESY+ VTIYFSDIVGFTSLS++STPMQV+ LLN LY FD +++N+ VYKVETIGDAY+VVSGLP+R + HA +I++MSL+ L + F I HR +L +RIGMHSG V AGVVG KMPRYCLFGDTVNT+SRMESNG +KIH+S+ T D+L F + RG +E+KGKG QTTYWL G
Sbjct: 689 SGGSVETIAQ------NNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENED--LSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1224 HSP 2 Score: 187.963 bits (476), Expect = 4.393e-48 Identity = 139/486 (28.60%), Postives = 255/486 (52.47%), Query Frame = 2
Query: 215 QIVPAVDIAFEKIKQKFIRFRN-FELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQV--ILGPLDDFNIANAVRLSD-GRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDA---------NFKIAKEIYKQKLTA--RPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFH-KGDYAFISFDILNKSQSQRPWYSPLNST-QENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKS------KSLGSQD--VSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFAXXXXXXXXXXXXXXXXXXXXXY--RHFKFHIELKAMNWLIMWDCIETTEKR 1585
++ P D+A E++ ++ I N L+ L+ ++ ++ ++ R Q+ I+G + +A R+S + +P++TP G + L K+++Q++T ++ + + +F+ +KWK +++F ++ ++ +LQ NF E + ++ R ++ LR S + +IILCA P+ +R+IM AA+DLG G+Y FI+ D+ S +++PW ++ +ENE K+AYR+L I+L + + +K+F VK+++ ++ +D ++ F+ AF+D+VL+YA ALN+ + + +G +IT +M ++ GI+GNV ID NGDR +DYSLLD+DP F VA +G+ + V Q+ W V +PP D P CG+ + C G+ L + ++ L+I +V + I+ R +K EL AM+W I W+ ++ E +
Sbjct: 69 KVKPLADLALERVYREGILPNNSVNLIYRDSKLSDAIGPNV-----AVEQLLRKQIDCIIGYAYGYALAPVARMSPYWKNGIPIITPIGLTMSLDDKREYQLMTRINSPYKVVSSAVSTLFNTYKWKRH------IFMFHHAKAPSVAVGECFLLMASLQHPLRKVMEMQHNFFTFNEDHGANISKAERHNQFRNYLRASSNMANVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDVSTGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVG--QLHW--VGGKPPTDLPICGYDKSKCPQGYPLHVYLLMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 539
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3]) HSP 1 Score: 529.25 bits (1362), Expect = 1.048e-174 Identity = 274/546 (50.18%), Postives = 386/546 (70.70%), Query Frame = 2
Query: 1793 SENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKK---IEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEE-NPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQF---RQIPFRPYLGKESENHGSEI--DSIIKQM---WEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGS-----FIITERGQIELKGKGFQTTY 3373
S S+ET+A N Q+++KT ++K +VAIK + + KK ++++++ L+++KK+KDL +DHI RF GAC++ H C+++EYCPKGSL+D+LEN++I+LD + K+SL+ D+ +G+ +LH S I HG LKSSNC++DSRFV+K+TDFGL +L ++ LEE +A+Y+ +LWTAPE+LR+SN+ GT KGDIYSFAIIL E+++R GVF L + + P EIV+RV++ Q P RP++ + E G + D+++ M W E P +RPE+ +++ R N+ ++ N++DNLL RMEQYANNLEGLV +RT++YL EK+K E+LL+ +LP ++A LI V AESY+ VTIYFSDIVGFTSLS++STPMQV+ LLN LY FD +++N+ VYKVETIGDAY+VVSGLP+R + HA +I++MSL+ L + F I HR +L +RIGMHSG V AGVVG KMPRYCLFGDTVNT+SRMESNG M + S + K F + F+ E+ IE +GK T +
Sbjct: 100 SGGSVETIAQ------NNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENED--LSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLRMFWNFSLYKIYKFKVFKNKIELDFLKNEKESIEFEGKKMVTEF 636
BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-22 (Receptor-type guanylate cyclase gcy-22 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTY1]) HSP 1 Score: 435.647 bits (1119), Expect = 3.851e-134 Identity = 226/507 (44.58%), Postives = 337/507 (66.47%), Query Frame = 2
Query: 1880 NGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVL-KTFGSFIITERGQIELKGKGFQTTYWLHGEGE 3394
+ +VA K H + K+ +K+++++ND++C+FIG L+ + + YC +GSLQDV+ +++DW FK+SL++D+ + YLH S IGPHG L SS CL+D R+ VK++ FGL + K + ++E R+ L TAPE +R++N + T + DIYSFAII E+I + + L E ET + +E+V ++K+ + P RP L E E++GS + +++ W E P QRP IK + + N S N++D++ + +EQYA+NLE V R ++ EEK++++ LLY MLPK VA +L + V E+++ VTI+FSD+V FT+L++ TP+QV+ LLN LYTTFD+I+E +DVYKVETIGD Y+ VSGLP RNGN HA+EIS MS + LKA+ TF++PH R+++R+G+H+GPV GVVG+ MPRYCLFGD+VNTASRMESNG+ ++HIS + L + G + RG++ +KGKG T+WL + E
Sbjct: 551 DSVVARK---HNFRATFTKNDRAMFRKMRNVDNDNLCKFIGLSLDSPTLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADAIYYLHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLSAI---KQYEVKEQ-----RDFLHTAPEHIRDTNLPI--TKEMDIYSFAIICSELITKKSAWDL-ENET-FDIEELVYKIKKGGRSPPRPSLETEDEHNGS-MSLLVRDCWNENPDQRPTSEQIKTLMKSMNH-NRSSNLMDHVFNVLEQYASNLEDEVQARMKELTEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTTLASRCTPLQVVNLLNDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNEHAKEISSMSFSLLKAIKTFRVPHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKPGRVHISTECMKFLTEVIGGYQTEPRGEVIVKGKGAVQTHWLLTDDE 1040 HSP 2 Score: 64.3142 bits (155), Expect = 4.731e-10 Identity = 98/472 (20.76%), Postives = 192/472 (40.68%), Query Frame = 2
Query: 89 LSIVVFNYFINAENSKKHQMVIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSM-SKSLWEIIDLLQNSTRPQVILGP--LDDFNIANAVRLSDGRY-RVPLLTPGGN-ALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMEND--NNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKP-EVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQ-ENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQ--KSKSLGSQDVSRF------VVAFHDSVLIYAHALNDCLDKNVSD--GDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQID---WVNVNNRPPLDTPKCGFSNTDCNFGFA 1438
+ ++ YF+ NS Q +G + N+++ L Q+ A+ +A+ +I + + +E + +T LT + ++ +I+ + V+LGP + +A +V +Y PL+ G L + ++ + ST + L+ + + +KW + L + +D IS+ ++ L + N + +Q ++ LR L + +R++I+C + E R++M + + G +Y +I + + W N T +N++ +A R L+ + + N+ +F +EV+ + + V D++L+YA+ALN + + G E K G +G V I+ N R + + ++D + V+ I D P+ V W PL TP CGF+ TDC F
Sbjct: 9 ICLLFSTYFLPPVNSAVLQ--VGFLAANDNT-TELAPFIGWGQVAGALGVAWSRIVE-YGLLPGYETMNLTWVLTNCREADAVGSVINYAEG--HAHVVLGPPCVRPAQVAGSV----AKYLDFPLILWGPPFDSSLLNQFEYPTIASTTSSTLYQATSLIRLLEYYKWT-----EIALIYYVARSDLIPRCTPLISD--FEGLVNNNDNLTITYRRQMSVITNTSYATALRNLKELARVVIVCLESDEARRNLMISISENGMDGDEYVYIMAESRRAGFASSFW----NGTDGKNDLALRAARKFLV--MDNQKYNDTTTFVQEVRAAFSRPPFSCPNCTNIDPTVSQVGPLGDALLLYAYALNRSIATGNPNPTGTEFCEVAKGMEFLGFTGKVIINQNSTRTPLFVVYNLDSTDKEMIVMQITEDLDDSKDPITLVATPAQIWDTWGGTVPLSTPICGFTGTDCPKSFT 457
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0346151) HSP 1 Score: 737.258 bits (1902), Expect = 0.000e+0 Identity = 446/1123 (39.72%), Postives = 662/1123 (58.95%), Query Frame = 2
Query: 137 KHQMVIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQ-KFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTR-PQV--ILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQ--DLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKD---NLRELSKNSRIIILCAKPEVIRDIMKAAYDLGF-HKGDYAFISFDILNKSQ--SQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKS------LGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVS------DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCN----FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHS-NIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEE----NPYAFYRNLLWTAPEILR-NSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFR----QIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
+ Q+V +L + S N N + +++P +++A +++ F+ +F++ +++ + S + I + T+ P+V + G ++ +A R +D ++VP+LT GGNA KK + + L Q +L V+ A+ + F W + I+ EN G+ + + + D + +Y+ D L+ ++ SRI+I+CA P+ IR IM A +L G+Y FI+ ++ ++ Q + +PWY ++ NE +KAY ++L +T P N + S E+K + ++ +S FV +F D VL+YA+ALN+ + ++ + +G + +M N+S GI+GNV ID+NGDR + YSLLDM+P T F++VA + +F AN +I W P D P CG+ C G+A+ + +++++A YRH+ E+ +M+W KV L+ ++M + AE H L+ + + +L+ SE+ + ++ G + Q+F G+++ VAIKP+ + + + +SL++++K++KDL +DH+ +F GACL+ + +L+EYCPKGSLQD+LEN+Q +LDW+F+ SL+ DI RGM +LHS +I HGNLKSSNC++DSRFV+K+TDFGL LR ++ L + N +A++ LLWTAPE+LR N EGT KGD+Y+F II+ EI R G FYLG PQEI+E VK + Q PFRP L + ++I+ II++ W E P +RP+ +K M R+FNK ++GNI+DNLL RME YANNLE LV +RT+ Y EEK+K E LLY +LP+SVA QLI +PV AE+++ VTIYFSDIVGFT++SAESTPMQV++ LN LYT FDSI+EN+DVYKVETIGDAY+VVSGLP RNGN HAREI+R++LA L+A+ F+I HR + RL +RIG+H+G AGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIHIS T + L FG+F+ T RG + +KGKG TYWL GE
Sbjct: 83 RRQLVFVALLPSVESDNK--NDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISR---DTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYAD-VWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTAL------IYQNENAKVKGNSVCFLCLAAIHDTIEE--HSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFE--ANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFG-YRHYIAEAEINSMSW--------------------KVSLE---------------DVMFRDAAERGLRGSFHSLV-------------KQSSQLTLMSED-MVSING-------DRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTK-ADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0083187) HSP 1 Score: 737.258 bits (1902), Expect = 0.000e+0 Identity = 446/1123 (39.72%), Postives = 662/1123 (58.95%), Query Frame = 2
Query: 137 KHQMVIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQ-KFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTR-PQV--ILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQ--DLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKD---NLRELSKNSRIIILCAKPEVIRDIMKAAYDLGF-HKGDYAFISFDILNKSQ--SQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKS------LGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVS------DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCN----FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHS-NIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEE----NPYAFYRNLLWTAPEILR-NSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFR----QIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
+ Q+V +L + S N N + +++P +++A +++ F+ +F++ +++ + S + I + T+ P+V + G ++ +A R +D ++VP+LT GGNA KK + + L Q +L V+ A+ + F W + I+ EN G+ + + + D + +Y+ D L+ ++ SRI+I+CA P+ IR IM A +L G+Y FI+ ++ ++ Q + +PWY ++ NE +KAY ++L +T P N + S E+K + ++ +S FV +F D VL+YA+ALN+ + ++ + +G + +M N+S GI+GNV ID+NGDR + YSLLDM+P T F++VA + +F AN +I W P D P CG+ C G+A+ + +++++A YRH+ E+ +M+W KV L+ ++M + AE H L+ + + +L+ SE+ + ++ G + Q+F G+++ VAIKP+ + + + +SL++++K++KDL +DH+ +F GACL+ + +L+EYCPKGSLQD+LEN+Q +LDW+F+ SL+ DI RGM +LHS +I HGNLKSSNC++DSRFV+K+TDFGL LR ++ L + N +A++ LLWTAPE+LR N EGT KGD+Y+F II+ EI R G FYLG PQEI+E VK + Q PFRP L + ++I+ II++ W E P +RP+ +K M R+FNK ++GNI+DNLL RME YANNLE LV +RT+ Y EEK+K E LLY +LP+SVA QLI +PV AE+++ VTIYFSDIVGFT++SAESTPMQV++ LN LYT FDSI+EN+DVYKVETIGDAY+VVSGLP RNGN HAREI+R++LA L+A+ F+I HR + RL +RIG+H+G AGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIHIS T + L FG+F+ T RG + +KGKG TYWL GE
Sbjct: 83 RRQLVFVALLPSVESDNK--NDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISR---DTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYAD-VWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTAL------IYQNENAKVKGNSVCFLCLAAIHDTIEE--HSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFE--ANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFG-YRHYIAEAEINSMSW--------------------KVSLE---------------DVMFRDAAERGLRGSFHSLV-------------KQSSQLTLMSED-MVSING-------DRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTK-ADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0302487) HSP 1 Score: 548.895 bits (1413), Expect = 1.273e-174 Identity = 394/1135 (34.71%), Postives = 583/1135 (51.37%), Query Frame = 2
Query: 173 NSSQNNLGNL----PTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVT------KTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDF--ISEVVYKTLQDANFKIA-----KEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLG-FHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILK-KAYRSLLIITLTLPESNNFKSFSEEVKQKSKSL------------GSQDVSRFVVAFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISG-NVHIDSNGDRNADYSLL--------------DMDP------KTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLR-GSKDHLLE-ENPYAFYRNLLWTAPEILRNS-NSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQI--PFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGED 3397
+SQ GNL P L I A+ +A E++ +R R L V + ++ + +LW + + +GP + + R++ + +P+++ K DF T + ++A+ F W S+ LY+ D+ G + ++E + TL DA I IY P + + + N+RI ++ +M + G KGDY + DI ++ Y ++ E L +A++S L I T S +F +F+ EV + + G + +S +D+V +YA AL + LD +G I +K G +V+ID NGD +Y++L + P + + ++ + K FSP IDWV P P+CGF C + I L++ ++VS+V+YR++++ EL ++ W I + ++ E + + S + + +L + + P+ H L+ V L S N + R +F+ G+YK + AIK + K ++I + + ++K ++D +D+IC FIGAC +P ++CI+SEYC +GSL+D+LEN+ +KLD +F S++ DI RG+IYLH S I HG L +SNCL+DSR+VVKLTDFGL + G +D + ++ A LL+ APE+LR +SLV GT +GD YSF I+L E+ R G F ET + P + +++V Q + P+RP L + E + +++ W E P RP+ + I+ R K G NI DN+++ ME+YANNLE LV RT+Q EEK+K + LL+ MLP+ VA QL + V E YE V+IYFSDIVGFT++SAE TP+QV++ LN LYT FDSI+ +YDVYKVETIGDAY+VVSGLP RNG+LHA EI+ MSL L A+ F+I HR RL +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMES+G +KIH S +L G + ERG I +KGKG Q TYWL GE E+
Sbjct: 47 TASQRRPGNLDYNRPGL-TISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALW--------TQQVAAYIGPQE--TCVHEGRMAAA-FNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSF----LYL-----DDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNP--FEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPT--ASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSP-----IDWVGGTR--PAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQ------------------STHPLIRTSQVSL---------------SSNP--------DADFRYTTIFTPIGLYKGQLYAIKKV-RKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPF----GETGLTPMQCLQKVLQPQDYLNPYRPSL-QPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRK-GMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEE 1101
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0302488) HSP 1 Score: 548.125 bits (1411), Expect = 2.752e-174 Identity = 395/1132 (34.89%), Postives = 584/1132 (51.59%), Query Frame = 2
Query: 173 NSSQNNLGNL----PTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVT------KTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDF--ISEVVYKTLQDANFKIA-----KEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLG-FHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILK-KAYRSLLIITLTLPESNNFKSFSEEVKQKSKSL------------GSQDVSRFVVAFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISG-NVHIDSNGDRNADYSLLDM----DPKTETFQVVAIVN---------GSDKKFSPVANVQ----IDWVNVNNRPPLDTPKCGFSNTDCNFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLR-GSKDHLLE-ENPYAFYRNLLWTAPEILRNS-NSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQI--PFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGED 3397
+SQ GNL P L I A+ +A E++ +R R L V + ++ + +LW + + +GP + + R++ + +P+++ K DF T + ++A+ F W S+ LY+ D+ G + ++E + TL DA I IY P + + + N+RI ++ +M + G KGDY + DI ++ Y ++ E L +A++S L I T S +F +F+ EV + + G + +S +D+V +YA AL + LD +G I +K G +V+ID NGD +Y++L + + +T + V S K P N++ IDWV P P+CGF C + I L++ ++VS+V+YR++++ EL ++ W I + ++ E + + S + + +L + + P+ H L+ V L S N + R +F+ G+YK + AIK + K ++I + + ++K ++D +D+IC FIGAC +P ++CI+SEYC +GSL+D+LEN+ +KLD +F S++ DI RG+IYLH S I HG L +SNCL+DSR+VVKLTDFGL + G +D + ++ A LL+ APE+LR +SLV GT +GD YSF I+L E+ R G F ET + P + +++V Q + P+RP L + E + +++ W E P RP+ + I+ R K G NI DN+++ ME+YANNLE LV RT+Q EEK+K + LL+ MLP+ VA QL + V E YE V+IYFSDIVGFT++SAE TP+QV++ LN LYT FDSI+ +YDVYKVETIGDAY+VVSGLP RNG+LHA EI+ MSL L A+ F+I HR RL +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMES+G +KIH S +L G + ERG I +KGKG Q TYWL GE E+
Sbjct: 47 TASQRRPGNLDYNRPGL-TISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALW--------TQQVAAYIGPQE--TCVHEGRMAAA-FNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSF----LYL-----DDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNP--FEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPT--ASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTR--PAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPRRLPPQ------------------STHPLIRTSQVSL---------------SSNP--------DADFRYTTIFTPIGLYKGQLYAIKKV-RKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPF----GETGLTPMQCLQKVLQPQDYLNPYRPSL-QPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRK-GMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEE 1103
BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304792) HSP 1 Score: 544.273 bits (1401), Expect = 4.719e-173 Identity = 391/1135 (34.45%), Postives = 581/1135 (51.19%), Query Frame = 2
Query: 173 NSSQNNLGNL----PTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVT------KTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDF--ISEVVYKTLQDANFKIA-----KEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLG-FHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILK-KAYRSLLIITLTLPESNNFKSFSEEVKQKSKSL------------GSQDVSRFVVAFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISG-NVHIDSNGDRNADYSLL--------------DMDP------KTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLR-GSKDHLLE-ENPYAFYRNLLWTAPEILRNS-NSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQI--PFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGED 3397
+SQ GNL P L I A+ +A E++ +R R L V + ++ + +LW + + +GP + + R++ + +P+++ K DF T + ++A+ F W S+ LY+ D+ G + ++E + TL DA I IY P + + + N+RI ++ +M + G KGDY + DI ++ Y ++ E L +A++S L I T S +F +F+ EV + + G + +S +D+V +YA AL + LD +G I +K G +V+ID NGD +Y++L + P + + ++ + K FSP IDWV P P+CGF C + I L++ ++VS+V+YR++++ EL ++ W I + R+ + +N+ + + + + +P S++ L +N D + R +F+ G+YK + AIK + K ++I + + ++K ++D +D+IC FIGAC +P ++CI+SEYC +GSL+D+LEN+ +KLD +F S++ DI RG+IYLH S I HG L +SNCL+DSR+VVKLTDFGL + G +D + ++ A LL+ APE+LR +SLV GT +GD YSF I+L E+ R G F ET + P + +++V Q + P+RP L + E + +++ W E P RP+ + I+ R K G NI DN+++ ME+YANNLE LV RT+Q EEK+K + LL+ MLP+ VA QL + V E YE V+IYFSDIVGFT++SAE TP+QV++ LN LYT FDSI+ +YDVYKVETIGDAY+VVSGLP RNG+LHA EI+ MSL L A+ F+I HR RL +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMES+G +KIH S +L G + ERG I +KGKG Q TYWL GE E+
Sbjct: 47 TASQRRPGNLDYNRPGL-TISGAISLAVEEVNAGRLRDRGHSLQFVVAETYGEEVVSIRQTAALW--------TQQVAAYIGPQE--TCVHEGRMAAA-FNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSF----LYL-----DDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNP--FEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPT--ASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSP-----IDWVGGTR--PAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDF--------REVQIHENEREQQSQKQTRSTHPLIRTSQVS---------------LSSNPDA-------------------------------DFRYTTIFTPIGLYKGQLYAIKKV-RKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPF----GETGLTPMQCLQKVLQPQDYLNPYRPSL-QPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRK-GMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEE 1088
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 762.681 bits (1968), Expect = 0.000e+0 Identity = 442/1030 (42.91%), Postives = 628/1030 (60.97%), Query Frame = 2
Query: 353 LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS---QSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVV-----AFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETP-IEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
L+ S P +GP D++ + R + + VP++T G ALG + +T+ T + L +L M F W K+ L D +ND+ F E Y +++ N ++ + P + + LR++S +R++ +C K E R +M + GF + +YAF D+ +S RPW ++ K+A++S+ I+T P++ +K F ++K ++ + + +V ++ +FHD V++Y+HALND +D++ S GD + ++M N++ +G++G V +D NGDR D++L DM D KT +Q+V++ NGS K+ +++ W+ RPP D P+CGF N + C +S ++ I II V++ IYR K EL A W + W+ I+ + N K++ C + + + R SN+ SL T+ G N Q+++KTG YK I AIK ++ K+IE+ + +L ++K ++D+ N+H+ RFIGAC++P ++CIL+EYCP+GSLQD++E++ I LDW+F++SLI DI +GM +LH S I HGNLKSSNC++DSRFV+K+TD+GL+ KD L++ +AFY LWTAPE+LR N GT KGD+YSF IILQE+ GVFYL E P + P+EI+ERV + R RP L +S H E+ ++ + W E +RP+ IKV+ RK N G NILDNLLSRMEQYANNLE LV +RT+ Y EEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPM+V+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LHAREI+RMSLA L+A+ +F+I HR + +L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIH+S T VL+ F F + RG +E+KGKG TYWL GE
Sbjct: 116 LKFSYNPWAFIGPGCDYSSSPVARFTT-HWEVPMITSGARALGFNL---YSSITNIGPTHKKLGEFVLRMHRHFGWD----KHAMLMFNDNKNDDRPCYFAVEGPYTQMREDNITADDLVFNED--EEPLRYDELLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPW---ARGDADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHWLK--GRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMS-----------------NTEKVLRRACSKLTI---------------------------------SLRGSNYG--SLLTMDG-------NFQIYAKTGYYKGNITAIK-YVNKKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFH--KDSNLDD-VHAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYL---EGPCLSPKEIIERVVEGRWPYLRPLLCPQS--HSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGE 1061
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 762.681 bits (1968), Expect = 0.000e+0 Identity = 442/1030 (42.91%), Postives = 628/1030 (60.97%), Query Frame = 2
Query: 353 LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS---QSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVV-----AFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETP-IEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
L+ S P +GP D++ + R + + VP++T G ALG + +T+ T + L +L M F W K+ L D +ND+ F E Y +++ N ++ + P + + LR++S +R++ +C K E R +M + GF + +YAF D+ +S RPW ++ K+A++S+ I+T P++ +K F ++K ++ + + +V ++ +FHD V++Y+HALND +D++ S GD + ++M N++ +G++G V +D NGDR D++L DM D KT +Q+V++ NGS K+ +++ W+ RPP D P+CGF N + C +S ++ I II V++ IYR K EL A W + W+ I+ + N K++ C + + + R SN+ SL T+ G N Q+++KTG YK I AIK ++ K+IE+ + +L ++K ++D+ N+H+ RFIGAC++P ++CIL+EYCP+GSLQD++E++ I LDW+F++SLI DI +GM +LH S I HGNLKSSNC++DSRFV+K+TD+GL+ KD L++ +AFY LWTAPE+LR N GT KGD+YSF IILQE+ GVFYL E P + P+EI+ERV + R RP L +S H E+ ++ + W E +RP+ IKV+ RK N G NILDNLLSRMEQYANNLE LV +RT+ Y EEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPM+V+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LHAREI+RMSLA L+A+ +F+I HR + +L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIH+S T VL+ F F + RG +E+KGKG TYWL GE
Sbjct: 116 LKFSYNPWAFIGPGCDYSSSPVARFTT-HWEVPMITSGARALGFNL---YSSITNIGPTHKKLGEFVLRMHRHFGWD----KHAMLMFNDNKNDDRPCYFAVEGPYTQMREDNITADDLVFNED--EEPLRYDELLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPW---ARGDADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHWLK--GRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMS-----------------NTEKVLRRACSKLTI---------------------------------SLRGSNYG--SLLTMDG-------NFQIYAKTGYYKGNITAIK-YVNKKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFH--KDSNLDD-VHAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYL---EGPCLSPKEIIERVVEGRWPYLRPLLCPQS--HSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGE 1061
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr2 (natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZDB-GENE-141030-2]) HSP 1 Score: 731.48 bits (1887), Expect = 0.000e+0 Identity = 444/1081 (41.07%), Postives = 641/1081 (59.30%), Query Frame = 2
Query: 215 QIVPAVDIAFEKI-KQKFIRFRNFELVTV-TKTLTKSMSKSLWEIIDL-LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIF-DMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQS---QRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKS-----KSLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKK--FSPVANVQIDWVNVNNRPPLDTPKCGFSNT-DCNFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDI 3400
+++PA+ +A EKI K +R L+ T+ + S S++ +II + + +P +GP +++A+ R + +++PL+T GG A G K ++F+ + T T + L + + +F W R+ L IF D++ D+ F+SE +Y L++ N + Y+ + T N+KD + + N RI+ +C IMK D DYA D+ +S S PW + Q N+ +K ++S+ ++T P+S + +F +E+ +++ L + FHD ++YA AL++ L VS DG +IT +M+N+ + G++G V ID R D+SL M + K+ + +V NG+ K+ +SP +Q W PPLD P CGFS + + ++ + LII + S +IYR K EL M W I W+ +L+ E+ NK ++ + L Q GS S SL T G +Q+F+KTG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RFIGAC++P ++CI++EYCP+GSLQD+LEN+ I LDW+F++SLI DI +GM YLH S IG HGNLKSSNC++DSRFV+K+TD+GL R S ++ E+ +A Y LWTAPE+L +GT KGD+YSF IILQEI RNG FY+ + + P+EI+++V+ ++ FRP ++ H E+ +++ W E P +RP+ +IKV KFNK L LSRMEQYANNLE LV +RT+ YLEEKRKAE+LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTS+SAESTP+QV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LHAREI+ MSLA L+ + TF+I HR + +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMES G+A++IH+S T +VL FG F + RG +E+KGKG TYWL GE D+
Sbjct: 54 RVLPAIRMAQEKIQKSGLLRGHTINLLNFSTEDSSGSCSENEAQIIAVDTKLYHKPDAFIGPGCTYSVASVGRFAS-HWKLPLITAGGPAYGFDKWEEFKTIVRTGPTTKKLGDFVNYLHGQFNWSSRA-----LMIFHDLKQDDRPHYFLSEGIYTVLREENITVLAFPYEDEQTY---NYKDMITFIKDNGRIVYICGPLPTFFQIMKLFEDEVKSPEDYAIFYLDVFAESLSGDVPMPWQG--SDIQWNDPIK-LFQSVFVVTYQEPDSPEYTAFRKELHKRAIQDFNVQLEPSMMDFIAGCFHDGFVLYAKALSEALADGVSQNDGINITARMQNRRLWGVTGLVSIDQKNARFTDFSLWAMTNLKSGQYAIVGHYNGTSKEILWSPTEKIQ--WPK--GCPPLDYPPCGFSPCKEDHLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWE-----------------ELQFESPNK-------------------------YHKRAGSRLTLSQRGS----------SYGSLITAHG-------KYQLFAKTGYFKGNLVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEN---EDSHALYAKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVEGMD--LSPKEIIQKVRNGQKPYFRP--TTDNSRHCEELTILMEGCWSEDPAERPDFSHIKVFIAKFNKQHQYSQYL---LSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFELQLRGDVEMKGKGKMRTYWLLGEKTDV 1048
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4]) HSP 1 Score: 723.005 bits (1865), Expect = 0.000e+0 Identity = 431/1105 (39.00%), Postives = 636/1105 (57.56%), Query Frame = 2
Query: 146 MVIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQK---FIRFRNFELVTVTKTLTKSMSKSLWEIIDL-LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGD----FISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVV-----AFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKA-RYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYL-GEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
+V+ +IL Q+N ++ PA+D A ++ R R + ++ S+S+ ++ + L+ P +GP D+ ++ V L + +P++T G A+ + + + +T+T T + L L ++ F W S L +F +D +G+ F E +Y + + N ++++ P N+ + L ++ + R++ +C P+V R ++ + G K +Y F DI S RP ++ K+A++S+ I+T P++ +K F ++K +K + + V ++ F+D +++Y HALN+ L + G+ ++++M N++ G++G V ID NGDR D++L DM D T FQ+VA+ NG+ K+ + + + I W + P+D P CGF N + C +S +L +ILII V++ IYR K EL A W I WD I+ + KA R + +K+ L N L T+ + Q+F +KTG +K IVAIK I + +++E+ + +L ++K ++D+ N+H+ RFIGAC++P ++CI++EYCP+GSLQ++LEND I LDW+FK+SLI DI +GM +LH S I HGNLKSSNC++D+RFV+K+TD+GL +R D E+ +++Y LW APE+ R GT KGD+YSF IILQE+ R GVFYL G+ + P+EIV+RV RP L ++ H E+ ++++ W E P RPE +I V+ RK N++ +I+ + QYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTSLSAESTP+QV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH REI+RMSLA L+A+ TF+I HR D +L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNT+SRMESNG+ +KIH+S T VL+ F F + RG +E+KGKG TYWL GE
Sbjct: 48 IVLAVIL----PQHNTSYPWAWPRVGPALDRAIARVNANPNLLPRHRVRHVFANSEDRDGICSESMAPLMAVDLKFEHNPWAFIGPGCDYT-SSPVGLFTAHWGLPMITAGAPAVAFLQMEIYTSITNTGPTHKKLGEYALHLYRHFGWNQHS-----LLMF---SDTKMGERACYFALEGLYTEMHEENITTMDLVFEEN--KGPVNYSELLHKIQGDGRVVFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAKEAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPG--GKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMSHLEKALRSTGSKLTLSLRGSNY------------------------GSLLTTDGNFQVF------------------------------------AKTGYFKGNIVAIKYI-NRRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRTESD---TEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDL---LSPKEIVDRVALGEWPYLRPSLNPQA--HSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNRSVPHYSIV------LSQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1060
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4]) HSP 1 Score: 710.294 bits (1832), Expect = 0.000e+0 Identity = 398/883 (45.07%), Postives = 547/883 (61.95%), Query Frame = 2
Query: 788 IILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVV-----AFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKA-RYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYL-GEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
+ +C P+V R ++ + G K +Y F DI S RP ++ K+A++S+ I+T P++ +K F ++K +K + + V ++ F+D +++Y HALN+ L + G+ ++++M N++ G++G V ID NGDR D++L DM D T FQ+VA+ NG+ K+ + + + I W + P+D P CGF N + C +S +L +ILII V++ IYR K EL A W I WD I+ + KA R + +K+ L N L T+ + Q+F +KTG +K IVAIK I + +++E+ + +L ++K ++D+ N+H+ RFIGAC++P ++CI++EYCP+GSLQ++LEND I LDW+FK+SLI DI +GM +LH S I HGNLKSSNC++D+RFV+K+TD+GL +R D E+ +++Y LW APE+ R GT KGD+YSF IILQE+ R GVFYL G+ + P+EIV+RV RP L ++ H E+ ++++ W E P RPE +I V+ RK N+ S NILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTSLSAESTP+QV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH REI+RMSLA L+A+ TF+I HR D +L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNT+SRMESNG+ +KIH+S T VL+ F F + RG +E+KGKG TYWL GE
Sbjct: 2 VFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAKEAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPG--GKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMSHLEKALRSTGSKLTLSLRGSNY------------------------GSLLTTDGNFQVF------------------------------------AKTGYFKGNIVAIKYI-NRRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRTESD---TEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDL---LSPKEIVDRVALGEWPYLRPSLNPQA--HSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNREHRS-NILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 812
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 603.208 bits (1554), Expect = 0.000e+0 Identity = 297/504 (58.93%), Postives = 386/504 (76.59%), Query Frame = 2
Query: 1847 HQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGK 3355
+Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RF+GAC++P ++CI++EYCP+GSLQD+LEN+ I LDW+F+ SLI DI +GM +LH S IG HGNLKSSNC++DSRFV+K+TD+GL R S + ++ YA Y LWTAPE+LR + GT KGD+YSF IILQEI RNG FY+ + + P+EIV++V+ ++ FRP + + H E+ ++ + W E PL RP+ IK KFNK G S +ILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE+LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTS+SAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH REI+RMSLA L+A+ TF+I HR + +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A++IHIS T +VL F F + RG IE+K K
Sbjct: 53 YQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD--LSPKEIVQKVRNGQRPYFRPTV--DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 547
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 602.823 bits (1553), Expect = 0.000e+0 Identity = 297/504 (58.93%), Postives = 386/504 (76.59%), Query Frame = 2
Query: 1847 HQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGK 3355
+Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RF+GAC++P ++CI++EYCP+GSLQD+LEN+ I LDW+F+ SLI DI +GM +LH S IG HGNLKSSNC++DSRFV+K+TD+GL R S + ++ YA Y LWTAPE+LR + GT KGD+YSF IILQEI RNG FY+ + + P+EIV++V+ ++ FRP + + H E+ ++ + W E PL RP+ IK KFNK G S +ILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE+LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTS+SAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH REI+RMSLA L+A+ TF+I HR + +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A++IHIS T +VL F F + RG IE+K K
Sbjct: 138 YQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD--LSPKEIVQKVRNGQRPYFRPTV--DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 632
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 602.438 bits (1552), Expect = 0.000e+0 Identity = 297/504 (58.93%), Postives = 386/504 (76.59%), Query Frame = 2
Query: 1847 HQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGK 3355
+Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RF+GAC++P ++CI++EYCP+GSLQD+LEN+ I LDW+F+ SLI DI +GM +LH S IG HGNLKSSNC++DSRFV+K+TD+GL R S + ++ YA Y LWTAPE+LR + GT KGD+YSF IILQEI RNG FY+ + + P+EIV++V+ ++ FRP + + H E+ ++ + W E PL RP+ IK KFNK G S +ILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE+LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTS+SAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH REI+RMSLA L+A+ TF+I HR + +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A++IHIS T +VL F F + RG IE+K K
Sbjct: 183 YQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD--LSPKEIVQKVRNGQRPYFRPTV--DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 677
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 602.438 bits (1552), Expect = 0.000e+0 Identity = 297/504 (58.93%), Postives = 386/504 (76.59%), Query Frame = 2
Query: 1847 HQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGK 3355
+Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RF+GAC++P ++CI++EYCP+GSLQD+LEN+ I LDW+F+ SLI DI +GM +LH S IG HGNLKSSNC++DSRFV+K+TD+GL R S + ++ YA Y LWTAPE+LR + GT KGD+YSF IILQEI RNG FY+ + + P+EIV++V+ ++ FRP + + H E+ ++ + W E PL RP+ IK KFNK G S +ILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE+LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTS+SAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH REI+RMSLA L+A+ TF+I HR + +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A++IHIS T +VL F F + RG IE+K K
Sbjct: 106 YQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD--LSPKEIVQKVRNGQRPYFRPTV--DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 600
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543]) HSP 1 Score: 602.438 bits (1552), Expect = 0.000e+0 Identity = 297/504 (58.93%), Postives = 386/504 (76.59%), Query Frame = 2
Query: 1847 HQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGK 3355
+Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RF+GAC++P ++CI++EYCP+GSLQD+LEN+ I LDW+F+ SLI DI +GM +LH S IG HGNLKSSNC++DSRFV+K+TD+GL R S + ++ YA Y LWTAPE+LR + GT KGD+YSF IILQEI RNG FY+ + + P+EIV++V+ ++ FRP + + H E+ ++ + W E PL RP+ IK KFNK G S +ILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE+LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTS+SAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH REI+RMSLA L+A+ TF+I HR + +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A++IHIS T +VL F F + RG IE+K K
Sbjct: 211 YQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD--LSPKEIVQKVRNGQRPYFRPTV--DISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 705
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr1 (natriuretic peptide receptor 1 [Source:MGI Symbol;Acc:MGI:97371]) HSP 1 Score: 766.918 bits (1979), Expect = 0.000e+0 Identity = 440/1084 (40.59%), Postives = 649/1084 (59.87%), Query Frame = 2
Query: 215 QIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSM-----SKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNL-RELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQS-------QRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVK---QKSKSLGSQDVSRFVV--AFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSN-IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
++ PAV++A ++K + + + V + + + + +DL + P V LGP ++ A R + +RVPLLT G ALG+ K ++ + T T + L + A+ W+ ++ + LY D D+ FI E +Y +++ ++ + Q+ P+H L R + + R+I +C+ P+ R++M A D G DY F D+ +S ++PW ++ ++A+++ IIT P++ + F +++K K + +D + ++ +FHD +L+Y A+ + L + V+DG++IT++M N+S G++G + ID NGDR+ D+SL DMDP+T F+VV NG+ ++ V+ ++ W PP D PKCGF N D CN F L+ + + L+ +VS IYR + EL + W + W+ ++ + ++E H + L + R SN+ SL T G QF Q+F+KT YK +VA+K + + K+IE+ + +L ++K ++D+ N+H+ RF+GAC +P ++CIL+EYCP+GSLQD+LEN+ I LDW+F++SL DI +GM++LH+ IG HGNLKSSNC++D RFV+K+TD+GL+ R + E + + LWTAPE+LR ++ G+ GD+YSF IILQEI R+GVFY+ + + P+EI+ERV + Q PFRP + +S H E+ ++++ W E P +RP + I++ RKFNK +S NILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD++++N+DVYKVETIGDAY+VVSGLP RNG LHARE++RM+LA L A+ +F+I HR +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A++IH+S T VL+ F F + RG +E+KGKG TYWL GE
Sbjct: 50 RVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHS-PAVFLGPGCVYSAAPVGRFT-AHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWE---HQALVLYA-DRLGDDRPCFFIVEGLYMRVRE---RLNITVNHQEFVEGDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWE---RDDGQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPL--GYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPS------------------------------------------SLERHLRSAGSRLTL--------SGRGSNY--GSLLTTEG-QF------QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPE----PEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLD--LSPKEIIERVTRGEQPPFRPSMDLQS--HLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 719.153 bits (1855), Expect = 0.000e+0 Identity = 431/1094 (39.40%), Postives = 621/1094 (56.76%), Query Frame = 2
Query: 182 QNNLGNLPTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSMSKSLWEIIDL-LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQD-FQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRE-LSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS-------QSQRPWYSPLNSTQEN-EILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKS-----LGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
++NL ++ PAV +A E + + +L V+ L + S+ L + + L+ P ++LGP + A+ R + +R+PLLT G A G K + ++ L T + L ++ + F W R+ L D D+ F E V++ LQ +N + ++Y AR P + + N RI+ +C E++ +I+ A GDY F D+ +S + RPW N TQE + L++A++++L+IT P + ++ F + +++ L ++ F+D +L+YA LN+ + + + DG I E+M+ + +G++G V +D N DR D+ L M D + FQ A +G++K+ I WV PPLD P C F D C+ ++ V I+ V S +I+R EL +M W I W+ E +F + Y +G R L S SL T G +Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RFIGAC++P ++CI++EYCP+GSLQD+LEND I LDW+F++SLI D+ +GM +LH S I HG+LKSSNC++DSRFV+K+TD+GL R + + ++ +A Y LWTAPE+L + G K D+YSFAIILQEI R+G FYL + + P+EIV++V+ ++ FRP + + N E+ ++++ W + P +RP+ IK R+FNK G + +ILDNLL RMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG HA EI+RM+LA L A+ +F+I HR +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQA+KIH+S T D L G F + RG +E+KGKG TYWL GE
Sbjct: 33 EHNLSYAWAWPRVGPAVALAVEALGRAL----PVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFAS-HWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVY-----AREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQD--NRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGR-PIPWVK--GAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWE-------------------------------------------ELQFGNSDRY---------HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD--LSPKEIVQKVRNGQRPYFRPSIDRTQLNE--ELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 600.897 bits (1548), Expect = 0.000e+0 Identity = 376/1018 (36.94%), Postives = 561/1018 (55.11%), Query Frame = 2
Query: 182 QNNLGNLPTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSMSKSLWEIIDL-LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQD-FQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRE-LSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS-------QSQRPWYSPLNSTQEN-EILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKS-----LGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSG 3160
++NL ++ PAV +A E + + +L V+ L + S+ L + + L+ P ++LGP + A+ R + +R+PLLT G A G K + ++ L T + L ++ + F W R+ L D D+ F E V++ LQ +N + ++Y AR P + + N RI+ +C E++ +I+ A GDY F D+ +S + RPW N TQE + L++A++++L+IT P + ++ F + +++ L ++ F+D +L+YA LN+ + + + DG I E+M+ + +G++G V +D N DR D+ L M D + FQ A +G++K+ I WV PPLD P C F D C+ ++ V I+ V S +I+R EL +M W I W+ E +F + Y +G R L S SL T G +Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RFIGAC++P ++CI++EYCP+GSLQD+LEND I LDW+F++SLI D+ +GM +LH S I HG+LKSSNC++DSRFV+K+TD+GL R + + ++ +A Y LWTAPE+L + G K D+YSFAIILQEI R+G FYL + + P+EIV++V+ ++ FRP + + N E+ ++++ W + P +RP+ IK R+FNK G + +ILDNLL RMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG HA EI+RM+LA L A+ +F+I HR +L +RIG+H+G
Sbjct: 33 EHNLSYAWAWPRVGPAVALAVEALGRAL----PVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFAS-HWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVY-----AREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQD--NRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGR-PIPWVK--GAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWE-------------------------------------------ELQFGNSDRY---------HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD--LSPKEIVQKVRNGQRPYFRPSIDRTQLNE--ELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 963
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372]) HSP 1 Score: 600.512 bits (1547), Expect = 0.000e+0 Identity = 301/547 (55.03%), Postives = 397/547 (72.58%), Query Frame = 2
Query: 1751 QGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
+G R L S SL T G +Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RFIGAC++P ++CI++EYCP+GSLQD+LEND I LDW+F++SLI D+ +GM +LH S I HG+LKSSNC++DSRFV+K+TD+GL R + + ++ +A Y LWTAPE+L + G K D+YSFAIILQEI R+G FYL + + P+EIV++V+ ++ FRP + + N E+ ++++ W + P +RP+ IK R+FNK G + +ILDNLL RMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG HA EI+RM+LA L A+ +F+I HR +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQA+KIH+S T D L G F + RG +E+KGKG TYWL GE
Sbjct: 75 KGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD--LSPKEIVQKVRNGQRPYFRPSIDRTQLNE--ELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 605
BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2g (guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:106025]) HSP 1 Score: 439.113 bits (1128), Expect = 1.115e-134 Identity = 239/536 (44.59%), Postives = 343/536 (63.99%), Query Frame = 2
Query: 1838 LRNHQ----MFSKTGVYKNGIVAIKPIMHTKKIEINK-SLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFE-TPIEPQEIVERVKQFRQ-IPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPE 3421
++ HQ F+ G+Y+ VA+ I + + K ++ +V + +L +++I F G C EP ++CI+++YC KGSLQDV+ N ++DWIFK S DI G+++LH S + HGNLK SNCL+DS +KL+ FGL + + + L WTAPE+LR S GT +GD+YSFAI+L+++I++ G FE P+EI+ R+K R +P RP L ++ + I +++++ W+E P RP +IK R+ + G +ILD+++ ++E YAN+LE +V +RT + + EKRK E LL MLP V QLI + V E +ESVTI+FSDIVGFT L + S+P+QV++LLN LY+ FD ++++DVYKVETIGDAY+V SGLP RNG HA EI+ M+L L FQI H + RL +RIG+H+GPV AGVVG+ MPRYCLFGDTVN ASRMES+ ++IH+S++T L G + + +RG I +KGKG QTT+WL +G+D LPE
Sbjct: 561 VKRHQDEELFFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQA---HGPFEDLEAAPEEIISRIKDPRAPVPLRPSLLEDKGD--GRIVALVRECWDESPELRPIFPSIKKTLREASPRGHV-SILDSMMGKLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWL--KGKDGFPVPLPE 1088 HSP 2 Score: 72.7886 bits (177), Expect = 2.173e-12 Identity = 66/244 (27.05%), Postives = 111/244 (45.49%), Query Frame = 2
Query: 749 KDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEI-LKKAYRSLLIITLT-----LPESNNFKSFSEEVKQK--SKSLGSQD-VSRFVVAFHDSVLIYAHALNDC--LDKNVSDGDHITEQMKNK--SINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRP------PLDTPKCGFSNTDC 1423
++ LR +S +R+IIL E R I++AA DLG G++ FI L S W L T++ I K Y S+ +I + + + K S+E+++ S+ S+D VS + HD++L+YA + + +K+ DG + ++ ++ GI+G V +DS G R+ DYS+ + + ++ + V W N +N P P CGF N C
Sbjct: 233 QEGLRNMSYVARVIILICSSEDARRILQAAVDLGLDTGEFVFILLQQLEDSF----WKEVL--TKDKVIRFPKVYESVFLIAPSAYGGGIGDDGFRKQVSQELRRPPFQSSITSEDQVSPYSAYLHDALLLYAQTVEEMRKAEKDFRDGRQLISTLRAGQVTLQGITGPVLLDSQGKRHVDYSVYALQESGNRSLFLPFLH-----YDSFQKVIRPWRNDSNTSWPHGSLPEYKPGCGFHNDLC 465
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18293|ANPRA_MOUSE (Atrial natriuretic peptide receptor 1 OS=Mus musculus OX=10090 GN=Npr1 PE=1 SV=2) HSP 1 Score: 766.918 bits (1979), Expect = 0.000e+0 Identity = 440/1084 (40.59%), Postives = 649/1084 (59.87%), Query Frame = 2
Query: 215 QIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSM-----SKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNL-RELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQS-------QRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVK---QKSKSLGSQDVSRFVV--AFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSN-IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
++ PAV++A ++K + + + V + + + + +DL + P V LGP ++ A R + +RVPLLT G ALG+ K ++ + T T + L + A+ W+ ++ + LY D D+ FI E +Y +++ ++ + Q+ P+H L R + + R+I +C+ P+ R++M A D G DY F D+ +S ++PW ++ ++A+++ IIT P++ + F +++K K + +D + ++ +FHD +L+Y A+ + L + V+DG++IT++M N+S G++G + ID NGDR+ D+SL DMDP+T F+VV NG+ ++ V+ ++ W PP D PKCGF N D CN F L+ + + L+ +VS IYR + EL + W + W+ ++ + ++E H + L + R SN+ SL T G QF Q+F+KT YK +VA+K + + K+IE+ + +L ++K ++D+ N+H+ RF+GAC +P ++CIL+EYCP+GSLQD+LEN+ I LDW+F++SL DI +GM++LH+ IG HGNLKSSNC++D RFV+K+TD+GL+ R + E + + LWTAPE+LR ++ G+ GD+YSF IILQEI R+GVFY+ + + P+EI+ERV + Q PFRP + +S H E+ ++++ W E P +RP + I++ RKFNK +S NILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD++++N+DVYKVETIGDAY+VVSGLP RNG LHARE++RM+LA L A+ +F+I HR +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A++IH+S T VL+ F F + RG +E+KGKG TYWL GE
Sbjct: 50 RVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHS-PAVFLGPGCVYSAAPVGRFT-AHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWE---HQALVLYA-DRLGDDRPCFFIVEGLYMRVRE---RLNITVNHQEFVEGDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWE---RDDGQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPL--GYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPS------------------------------------------SLERHLRSAGSRLTL--------SGRGSNY--GSLLTTEG-QF------QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPE----PEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLD--LSPKEIIERVTRGEQPPFRPSMDLQS--HLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18910|ANPRA_RAT (Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus OX=10116 GN=Npr1 PE=1 SV=1) HSP 1 Score: 765.763 bits (1976), Expect = 0.000e+0 Identity = 441/1084 (40.68%), Postives = 648/1084 (59.78%), Query Frame = 2
Query: 215 QIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSM-----SKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNL-RELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS-------QSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVK---QKSKSLGSQDVSRFVV--AFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSN-IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
++ PAV++A ++K + + + V + + + + +DL + P V LGP ++ A R + +RVPLLT G ALG+ K ++ + T T + L + A+ W+ ++ + LY D D+ FI E +Y +++ ++ + Q+ P+H L R + + R+I +C+ P+ R++M A + G DY F D+ +S Q+PW ++ ++A+++ IIT P++ + F +++K K + +D + ++ +FHD +L+Y A+ + L + V+DG++IT++M N+S G++G + ID NGDR+ D+SL DMDP+T F+VV NG+ ++ V+ ++ W PP D PKCGF N D CN F L+ + + LI +VS IYR + EL + W + W+ ++ + ++E H + L + R SN+ SL T G QF Q+F+KT YK +VA+K + + K+IE+ + +L ++K ++D+ N+H+ RF+GAC +P ++CIL+EYCP+GSLQD+LEN+ I LDW+F++SL DI +GM++LH+ I HGNLKSSNC++D RFV+K+TD+GL+ R + E + + LWTAPE+LR ++ G+ GD+YSF IILQEI R+GVFY+ + + P+EI+ERV + Q PFRP + +S H E+ ++++ W E P +RP + I++ RKFNK +S NILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD++++N+DVYKVETIGDAY+VVSGLP RNG LHARE++RM+LA L A+ +F+I HR +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIH+S T VL+ F F + RG +E+KGKG TYWL GE
Sbjct: 50 RVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHS-PAVFLGPGCVYSAAPVGRFT-AHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWE---HQALVLYA-DRLGDDRPCFFIVEGLYMRVRE---RLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWE---RGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPL--GYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPS------------------------------------------SLERHLRSAGSRLTL--------SGRGSNY--GSLLTTEG-QF------QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPE----PEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLD--LSPKEIIERVTRGEQPPFRPSMDLQS--HLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16066|ANPRA_HUMAN (Atrial natriuretic peptide receptor 1 OS=Homo sapiens OX=9606 GN=NPR1 PE=1 SV=1) HSP 1 Score: 756.903 bits (1953), Expect = 0.000e+0 Identity = 440/1085 (40.55%), Postives = 643/1085 (59.26%), Query Frame = 2
Query: 215 QIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSM-----SKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQD-ANFKIAK-EIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS-------QSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVK-----QKSKSLGSQDVSRFVVAFHDSVLIYAHALNDCL--DKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSN-IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
++ PAV++A ++K + + + TV + ++ + + +DL + P V LGP + A R + +RVPLLT G ALG K ++ + T ++ L + A+ W+ ++ LY + D F+ E ++ ++D N + E + L+ ++ LR + + R+I +C+ P+ R +M A + G DY F DI +S +RPW ++ ++A+++ IIT P++ + F +++K Q + ++ V+ +FHD +L+Y A+ + L V+DG++IT++M N+S G++G + IDS+GDR D+SL DMDP+ F+VV NG+ ++ V+ +++W PP D PKCGF N D CN L+ + + L+ +VS IYR + EL + W + W+ +E + ++E H + L + R SN+ SL T G QF Q+F+KT YK +VA+K + + K+IE+ + +L ++K ++D+ N+H+ RF+GAC +P ++CIL+EYCP+GSLQD+LEN+ I LDW+F++SL DI +GM++LH+ I HGNLKSSNC++D RFV+K+TD+GL+ R L E + Y LWTAPE+LR ++ V G+ GD+YSF IILQEI R+GVF++ + + P+EI+ERV + Q PFRP L +S H E+ ++++ W E P +RP + I++ RKFN+ +S NILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD++++N+DVYKVETIGDAY+VVSGLP RNG LHA E++RM+LA L A+ +F+I HR +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIH+S T VL+ FG F + RG +E+KGKG TYWL GE
Sbjct: 54 RVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDL-KWEHNPAVFLGPGCVYAAAPVGRFT-AHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALM---LYAY-RPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLS----HYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWE---RGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPL--GYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPS------------------------------------------SLERHLRSAGSRLTL--------SGRGSNY--GSLLTTEG-QF------QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR----DLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLD--LSPKEIIERVTRGEQPPFRPSLALQS--HLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P55202|ANPRB_ANGJA (Atrial natriuretic peptide receptor 2 OS=Anguilla japonica OX=7937 GN=npr2 PE=2 SV=1) HSP 1 Score: 730.324 bits (1884), Expect = 0.000e+0 Identity = 445/1125 (39.56%), Postives = 658/1125 (58.49%), Query Frame = 2
Query: 98 VVFNYFINAENSKK--HQMVIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQKFIRFRNFELVTV---TKTLTKSMSKSLWEIIDL-LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS---QSQRPWYSP-LNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSK---SLGSQDVSRFVVA--FHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDI 3400
VVF F+ A + + + ++L +N + + ++ PA+ +A + I++K R + + + T++ S+S +I+ + + +P GP +++A+ R + +++PL+T A G K++++ + T + L + F W R++ + D++ D+ FISE V+ L+ N + Y + + ++++ + L N RI+ +C + + M+ + G DYA D+ KS + +PW S +N T K ++S+ +IT P++ +K+F E+ ++K S+ + ++A F+D ++YA ALN+ L + S DG +IT++M+N+ G++G V D N DR+ D++L M + KT + +VA NG++K+ +I W PPLD P C FS + CN ++ + LII + S +IYR K EL M W I W+ +L+ E+ NK Y +C S L + Q GS S SL T G +Q+F+KTG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RFIGAC++P ++CI++EYCP+GSLQD+LEN+ I LDW+F++SLI DI +GM +LH S IG HGNLKSSNC++DSRFV+K+TD+GL R S ++ E+ +A Y LWTAPE+L +GT KGD+YSF IILQEI RNG FY+ + + P+EIV++V+ ++ FRP ++ H E+ +++ W E P RP+ IK+ K NK G S +IL+NLLSRMEQYANNLE LV +RT+ YLEEKRKAE+LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTS+SAESTP+QV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVS RNG LHAREI+ MSLA L+ + TF+I HR + +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIH+S T +VL FG F + RG +E+KGKG TYWL GE D+
Sbjct: 9 VVFTCFLMARCRTEIGKNITVVVMLPDNHLKYSFA----FPRVFPAIRMAHDDIQKKGKLLRGYTINLLNHSTESQGAGCSESQAQIMAVDTKLYEKPDAFFGPGCVYSVASVGRFVN-HWKLPLITAWAPAFGFDSKEEYRTIVRTGLSTTKLGEFAHYLHSHFNWTTRAF----MLFHDLKVDDRPYYFISEGVFLVLRRENITVEAVPYDDQ---KNSDYREMISSLKSNGRIVYICGPLDTFLEFMRIFQNEGLPPEDYAIFYLDMFAKSILDKDYKPWESSDINWTDP----IKLFKSVFVITAKEPDNPEYKAFQRELHARAKQEFSVQLEPSLEDIIAGCFYDGFMLYAQALNETLAEGGSQNDGINITQKMQNRRFWGVTGLVSTDKNNDRDIDFNLWAMTNHKTGQYGIVAYYNGTNKEIVWSETEKIQWPK--GSPPLDNPPCVFSMDEPFCNEDQLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWE-----------------ELQFESPNK--YHKCAGSRLT-----------------------ISQRGS----------SYGSLITAHG-------KYQLFAKTGYFKGNLVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEN---EDSHALYAKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVDGMD--LSPKEIVQKVRNGQKPYFRP--TTDTSCHSEELSILMEGCWAEDPADRPDFSYIKIFVMKLNKEG-STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSDSQSRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSATKEVLDEFGYFDLQLRGDVEMKGKGKMRTYWLLGEKTDV 1047
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|Q6VVW5|ANPRB_MOUSE (Atrial natriuretic peptide receptor 2 OS=Mus musculus OX=10090 GN=Npr2 PE=1 SV=2) HSP 1 Score: 719.153 bits (1855), Expect = 0.000e+0 Identity = 431/1094 (39.40%), Postives = 621/1094 (56.76%), Query Frame = 2
Query: 182 QNNLGNLPTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSMSKSLWEIIDL-LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQD-FQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRE-LSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKS-------QSQRPWYSPLNSTQEN-EILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKS-----LGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CN---FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
++NL ++ PAV +A E + + +L V+ L + S+ L + + L+ P ++LGP + A+ R + +R+PLLT G A G K + ++ L T + L ++ + F W R+ L D D+ F E V++ LQ +N + ++Y AR P + + N RI+ +C E++ +I+ A GDY F D+ +S + RPW N TQE + L++A++++L+IT P + ++ F + +++ L ++ F+D +L+YA LN+ + + + DG I E+M+ + +G++G V +D N DR D+ L M D + FQ A +G++K+ I WV PPLD P C F D C+ ++ V I+ V S +I+R EL +M W I W+ E +F + Y +G R L S SL T G +Q+F+ TG +K +VAIK + + K+IE+ + +L ++K ++D+ +H+ RFIGAC++P ++CI++EYCP+GSLQD+LEND I LDW+F++SLI D+ +GM +LH S I HG+LKSSNC++DSRFV+K+TD+GL R + + ++ +A Y LWTAPE+L + G K D+YSFAIILQEI R+G FYL + + P+EIV++V+ ++ FRP + + N E+ ++++ W + P +RP+ IK R+FNK G + +ILDNLL RMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG HA EI+RM+LA L A+ +F+I HR +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQA+KIH+S T D L G F + RG +E+KGKG TYWL GE
Sbjct: 33 EHNLSYAWAWPRVGPAVALAVEALGRAL----PVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFAS-HWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARA----ALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVY-----AREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQD--NRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGR-PIPWVK--GAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWE-------------------------------------------ELQFGNSDRY---------HKGAGSRLTLSLRGSSYGSLMTAHG-------KYQIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD--LSPKEIVQKVRNGQRPYFRPSIDRTQLNE--ELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039
BLAST of Guanylate cyclase vs. TrEMBL
Match: G4V651 (Guanylate cyclase OS=Schistosoma mansoni OX=6183 GN=Smp_142620 PE=3 SV=1) HSP 1 Score: 1023.08 bits (2644), Expect = 0.000e+0 Identity = 542/1095 (49.50%), Postives = 715/1095 (65.30%), Query Frame = 2
Query: 215 QIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPR--------SYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILN-KSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSK-----SLGSQDVSRFVVAFHDSVLIYAHALNDCLDK--NVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCN----FGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLV--EGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASVI 3433
Q++PA+D+A E I Q F F TV +++ ++ L NS VI GPL+DF +ANA R S Y VP++ P G A L K ++ MLT LFT+ DL++V + W P + +NV + + G F ++ K L A +K+ + L+ L ++RIIILC PEV+RDIM A+ L GDYAF + D+L+ +++ +RPWY +S +ENE ++AYR+L+ +TL P+S +++F+EEV+ ++ S +V+ F+ FHD+V +YA ALND L K +++G IT++M N++ G++G V ID+NGDRNADYSLLDM+P T F+VV G+DK S V IDW+N +N+PPL TP CGF ++C+ + + + ++++ ++ V+ I+ YR KF EL+AMNW+I WD ++ TEK RY ES++ + + + + R++S SE A N QMF++T Y IVA+KP+ ++E +K+L I+VKKVKDLN DHICR IG CLE H CI+ EYCPKGSLQDVLEN+QIKLDW+FKFSL+QDICRG++YLH GPHGNLKSSNCL+DSRFV+K+TDFGL +RG E + F+RNLLWTAPE+L + ++ + ++KGD+YSFAI+ QEI+YR GVFY+ F+ EP IV+ VK R+ PFRP L E ++ +I Q W++ P RP+ ++IK+ RK NKAGDS N+LDNLLSRMEQYANNLE LV QRT QYLEEK+K EDLLY MLP+SVA+QL RN+PVTAES+E VTIYFSDIVGFTSLSAESTPMQV+ELLN LYT FD I+EN+D YKVETIGDAY+V SGLPQRNGN HARE++RMS+AFLKA+F FQIPHR ++RL +RIG+HSGPVCAGVVG KMPRYCLFGDTVNT+SRMESNG +KIHIS+ T DVLKTF SFI+TERG +E+KGKG Q TYWLHGE IVDP+ P A ++
Sbjct: 95 QVLPAIDLALEDI-QSFPAFGGVSFTTVLILYIDALACDALALLTQL-NSNGVNVIFGPLNDFTLANAARFSTAMYNVPIVAPAGFAHQLSDKLEYGMLTRVLFTYSDLEWVFGNTLKHYGWLPDQQTPIAIVTTRNVRRREGVVGHTGMAGVFQHLILQKFLVKAAYKLLSVTLDDEFDVT----DRFLKRLPDSARIIILCTDPEVVRDIMLEAHKLNMVNGDYAFFNMDLLSSQTKLKRPWYRETSSPEENERARQAYRALMTVTLLKPDSPEYRTFTEEVRARALRDYDFSYRDSEVTPFIGTFHDAVKLYALALNDALAKGGTITNGTLITQEMWNRTFKGVTGVVRIDANGDRNADYSLLDMNPVTGDFEVVVNYFGNDKSLSTVLGRTIDWINTDNQPPLHTPPCGFDGSECHNSHFIHIGIVGAVVFILLMTMSLVLGIIFYRRAKFQAELRAMNWIIPWDALQVTEKHLRRYR-------------------RESDIRSPNQSSDPL------------------------RKIS--SETCTAAAA--------NSQMFARTAFYMKSIVALKPLRRQTRMEPSKALSIEVKKVKDLNCDHICRLIGVCLEVPHQCIVYEYCPKGSLQDVLENEQIKLDWMFKFSLMQDICRGVMYLHQIFGPHGNLKSSNCLVDSRFVLKITDFGLPHIRGPPPLESEVGSFIFHRNLLWTAPELLPDGDTTIYPRESIKGDVYSFAIVCQEIVYRKGVFYIQNFKN-CEPDFIVKEVKAHRKPPFRPTL-DSLEGCSEDLVQLICQAWDDDPSVRPDFQSIKLSMRKLNKAGDSNNVLDNLLSRMEQYANNLEELVEQRTAQYLEEKKKTEDLLYSMLPRSVAKQLFRNQPVTAESFEMVTIYFSDIVGFTSLSAESTPMQVVELLNRLYTLFDGIIENFDAYKVETIGDAYMVASGLPQRNGNKHAREVARMSIAFLKAIFEFQIPHRPEKRLELRIGIHSGPVCAGVVGQKMPRYCLFGDTVNTSSRMESNGLPLKIHISQQTFDVLKTFKSFIMTERGLVEMKGKGRQKTYWLHGEDCYIVDPIPPGAQIV 1128
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8HCY1 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 935.25 bits (2416), Expect = 0.000e+0 Identity = 517/1124 (46.00%), Postives = 718/1124 (63.88%), Query Frame = 2
Query: 206 TLDQIVPAVDIAFEKIKQ-KFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSD-GRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHK--------DNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQ-SQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKS-----LGSQDVSRFVVAFHDSVLIYAHALNDCLDKN----VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGF---AXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKA--RYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQG----GSFRNARRLSNWSEN--------------SLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENP-YAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSE----IDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASV 3430
+L+Q++P VDIA E + + + L+ S++ L + LLQ + ++LGP F +A R + YR P+LT GG A LR K ++ L +F ++ +L +F F WKPR + + L+I + D E+ + I K ++K R ++ + R + R+++LCA P+ +R+IM A +LGF G+Y F + D+ + + + +PW ++ + NE +AYR+L+ ITL P S +++FS++VK +KS ++V+ FV AFHD+V++YA A+ND + ++ +++G ITE+MKN++ GI+G V I++NGDR+ADYSLLDMD T F VVA G+ +K+ V +IDW N +N PP D PKCGF + C A +LLV++ + +VV VIYR + EL AMNW I W +E E+ A R S++ L+Q++ EE E ++ ++ ++H T+ LF GS R +N S++T+AG+ + Q+F+KT YK +VA+KP+ + K+IE+ LL++VK+VKDL +D++ RFIGACL+ + C++SEYCPKGSLQDVLEND + LDW+FKFSL+ DICRGMIYLH N G HGNLKSSNCL+DSRF +K+ DFGLQ LRG+KD+ +E+ Y+ YRN LWTAPE+LRN EGT +GD+YSFAII QEIIYR GVF++ +++ P EPQEIVE+VK+ +RP L E+ + E + + ++ W+E P RP +IK +FNK +SGNILDNLL RMEQY+NNLE LV +RT+ YLEEK+KAE+LLY MLPKSVA L+R E VTAE ++SVTIYFSDI GFT+LS+ESTP++V+ LLN LYT FD I+E YD YKVETIGDAY+VVSGLP RNG LHAREISRM+L+FL+ +++F+I H+ D +L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG +KIHIS T ++L+ G F+ T RG++E+KGKG Q TYWLHGEG+ IVDPV+ S+
Sbjct: 2 SLEQVLPVVDIAIETVTTLDLLHGHSVSLIANDSKCDYSVAPVLGVL--LLQQ--KIDLMLGPYCSFALAAVARYNRMPHYRRPILTTGGVASALRDKAEYFNLIRVGPSFDGVEKMLYLVFQRFNWKPRDVQTI-LFIELPDEDVKEKRTRDEIGVTQSRILCHGIEKHFVQEKYIVRRLQYEMHNAQFKSEIFRVMRDEIRLVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGKDLQQQD---------EEPE-QSQPHRHHQHRGQSHQKRTDSVRILFGNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFP-EPQEIVEKVKEISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPVVSNGSL 1109
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8HYF3 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 921.768 bits (2381), Expect = 0.000e+0 Identity = 513/1122 (45.72%), Postives = 713/1122 (63.55%), Query Frame = 2
Query: 206 TLDQIVPAVDIAFEKIKQ-KFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSD-GRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHK--------DNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQ-SQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKS-----LGSQDVSRFVVAFHDSVLIYAHALNDCLDKN----VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGF---AXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKA--RYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQG----GSFRNARRLSNWSEN--------------SLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENP-YAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSII--KQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASV 3430
+L+Q++P VDIA E + + + L+ S++ L + LLQ + ++LGP F +A R + YR P+LT GG A LR K ++ L +F ++ +L +F F WKPR + + L+I + D E+ + I K ++K R ++ + R + R+++LCA P+ +R+IM A +LGF G+Y F + D+ + + + +PW ++ + NE +AYR+L+ ITL P S +++FS++VK +KS ++V+ FV AFHD+V++YA A+ND + ++ +++G ITE+MKN++ GI+G V I++NGDR+ADYSLLDMD T F VVA G+ +K+ V +IDW N +N PP D PKCGF + C A +LLV++ + +VV VIYR + EL AMNW I W +E E+ A R S++ L+Q++ EE E ++ ++ ++H T+ LF GS R +N S++T+AG+ + Q+F+KT YK +VA+KP+ + K+IE+ LL++VK+VKDL +D++ RFIGACL+ + C++SEYCPKGSLQDVLEND + LDW+FKFSL+ DICRGMIYLH N G HGNLKSSNCL+DSRF +K+ DFGLQ LRG+KD+ +E+ Y+ YRN LWTAPE+LRN EGT +GD+YSFAII QEIIYR GVF++ +++ P EPQEIVE+VK+ +RP L E+ + E + ++ P + +IK +FNK +SGNILDNLL RMEQY+NNLE LV +RT+ YLEEK+KAE+LLY MLPKSVA L+R E VTAE ++SVTIYFSDI GFT+LS+ESTP++V+ LLN LYT FD I+E YD YKVETIGDAY+VVSGLP RNG LHAREISRM+L+FL+ +++F+I H+ D +L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG +KIHIS T ++L+ G F+ T RG++E+KGKG Q TYWLHGEG+ IVDPV+ S+
Sbjct: 2 SLEQVLPVVDIAIETVTTLDLLHGHSVSLIANDSKCDYSVAPVLGVL--LLQQ--KIDLMLGPYCSFALAAVARYNRMPHYRRPILTTGGVASALRDKAEYFNLIRVGPSFDGVEKMLYLVFQRFNWKPRDVQTI-LFIELPDEDVKEKRTRDEIGVTQSRILCHGIEKHFVQEKYIVRRLQYEMHNAQFKSEIFRVMRDEIRLVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGKDLQQQD---------EEPE-QSQPHRHHQHRGQSHQKRTDSVRILFGNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFP-EPQEIVEKVKEISNQMYRPTLDAETNDPDQERSEALINTKLLAGGPSRPASFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPVVSNGSL 1107
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8JDN4 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 917.146 bits (2369), Expect = 0.000e+0 Identity = 498/1054 (47.25%), Postives = 689/1054 (65.37%), Query Frame = 2
Query: 386 GPLDDFNIANAVRLSDGR-YRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGD-------FISEVVYKTLQDANFKIAKEIYKQKLTARPPNH--KDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQ-SQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGS-----QDVSRFVVAFHDSVLIYAHALNDCLDKN----VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGF---AXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARY--------------SDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPI-MHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKD-HLLEENPYAFYRNLLWTAPEILRN-SNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQ--FRQIPFRPYLGKESENHGSE----IDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDP 3409
GP F +A R + Y+ P++T G A L K+++ L D++ +LLA+F + W PR +N+ L I+ +++ L S ++ T+++ + I + K + H + R + + R+++LCA P+ +R+IM A++LGF G+Y F + D+ + + + RPWY +S + N AYR+L+ ITL P S ++ FS++VK +K S ++V+ FV AFHD+VL+YA A+ND L + +S+G IT +MK+++ GI+G V I++NGDRNADYSLLDMD T+ F VVA G+ K++ V+ IDW + +N PP D PKCGF N+ C A+ +LLV++ + +V+ VIYR + EL AMNW I W +E TE+ AR SD+ + Q N E EE++ +N + E + ++D + GS + S +S+ET+AG+ + Q+F+KT YK +VA+K I + K++E+N +L+++K+VKDL +D+I RFIGACL+ + C+++EYCPKGSLQD+LEND + LDW+FKFSL+ DICRGMIYLH + G HGNLKSSNCL+DSRF +K+ DFGL LRGSK+ +++ Y+ YRN LWTAPE+LRN S + EGT +GD+YSF II QEIIYR GVFY+ +++ P EPQ+I+E+++Q Q PFRP L +E + E + I++ W E P RP +K +FNK +SGNILDNLL RMEQY+NNLE LV +RT+QYLEEK+KAE+LLY MLPK VA L++ E VTAE ++SVTIYFSDI GFT+LS+ESTPM+V+ LLN LYT FD I+E YD YKVETIGDAY+VVSGLP RNGNLHAREI+RMSL+FL+ +F+F+I H+ D +L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG +KIHIS T +L+ G F+ TERG++E+KGKG Q TYWLHGE ++IVDP
Sbjct: 37 GPFCTFCLAAVARYNRYYLYQKPIITSGA-AANLEDKEEYYNLIRVGPMNFDIENMLLAIFQRYNWLPRQQQNL-LIIYVPDDETQLHKQRDETRVTFSRLLRTTIENRFSHQHRYILRVKPYSATNKHFQSEVFRCMREEVRLVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFSDKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSLITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVLIGVIYRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTFGNH--QQEGEEAQPLNPTPNEQQ--------QQDEDPAIAPKGSDVVS------SNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKELKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFP-EPQDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1071
BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1S3IRF8 (Guanylate cyclase OS=Lingula unguis OX=7574 GN=LOC106166491 PE=3 SV=1) HSP 1 Score: 912.909 bits (2358), Expect = 0.000e+0 Identity = 511/1152 (44.36%), Postives = 709/1152 (61.55%), Query Frame = 2
Query: 140 HQMVIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQKF--IRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQ-DFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILN----------------------------------------------KSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSK------SLGSQDVSRFVVAFHDSVLIYAHALNDCLDK--NVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDC---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSN-IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEG--EDIVD 3406
+++ IGIIL + N LP ++ PAV+ A KI+ K +R FE+ + L+ L + ++ S V LGP F +A R S + +PLLT G A + K ++Q+LT L + + Y ++ +F WK V + ++ + + FI E +Y+ + + + ++ + + ++ L ELS N+RI++LCA P +R+IM A +L F G+Y F + D+ + K+QS RPWY+ ++ EN+ +KAY +L+ ITL PES +++FSEEVK++++ + G ++V+ FV AFHD+V++YA ALN L+ NV+DG IT++M N++ GI+G V ID NGDRNADYSLLD++P+T+ F+VVA G+ K++ V +I W PP D PKCGF + C + + +LII ++ + IYRHFK EL M+W I W+ I + +++ L RR S+ S+ S++++A +Q N+ N QMF+ TG YK +VAIK I + I+++K +L+++K+++DL NDH+ RFIGAC++ +MCILSEYCPKGSLQDVLEN+QIKLDW+F++SL+QDI RGM YLHS I HGNLKSSN ++DSRFV+K+TDFGL LRG+ + +E+ YAFYR LW+APE+LR N EGT KGD+YSFA++ QEI+YRNG FYL E + PQ+I +VK ++ FRP LG E E+ +I++ W E P++RP+ ++K RK N+ GDSGNILDNLLSRMEQYANNLE LV +RT YLE+KRKAEDLLYLMLPKSVA QLIR +PV AE ++ TIYFSDI GFTSLS+ESTPM+V++LLN LYTTFD+I+E YDVYKVETIGDAY+VVSGLP +NGNLHAREI+RMSL+ L+A+ +F+I HR D +L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG ++IH+S T ++L +FGSF + RG +E+KGKG T+WL GE ED+++
Sbjct: 62 YKIKIGIILPCD--HNVQWRLP---RVGPAVEYATAKIEGKADTLRGYTFEICRMDSRLSDR-DGPLAAVN--MRFSRYAHVFLGPCFSFAVAPVARYSP-VWNIPLLTAGARAEAFKSKSNEYQLLTRMLGSHAQVGYFFFSILQQFSWK-----KVAM-VYPLTEIHKECYFIIEGIYERFPRSERE--HRPFLKRFDEKIQSKRELLEELSLNARIVVLCASPASVREIMLKAEELNFINGEYVFFNIDLFSSRRAQVAAVVVLCASPASVREIMLKAEELNFINGEYVFFNIDLFSSKNQSARPWYNASDTDAENQRARKAYEALMTITLRKPESEAYRNFSEEVKRRAEDEYKNFTYGEEEVNSFVGAFHDAVILYALALNQTLEDGFNVTDGAEITKRMWNRTFEGITGTVSIDENGDRNADYSLLDLNPETQEFEVVANYYGNRKQYDEVPGKKIHWAGGRTGPPPDVPKCGFDKSKCPNKELPEYAIVIMVFSSLLIIVSLGAFFIYRHFKLEAELAEMSWRIRWEDIMFAHHGGPKRVGSRISL---------------------------------------------------TRRYSSASQYSVDSIA-VQLSNVGNKQMFTTTGYYKAAVVAIKKI-NKPSIQLSKPVLLEIKRMRDLQNDHLVRFIGACIDIPNMCILSEYCPKGSLQDVLENEQIKLDWMFRYSLMQDIIRGMAYLHSTEIRSHGNLKSSNAVVDSRFVLKITDFGLHSLRGTP-YESDEDTYAFYRRKLWSAPELLRMHNRPPEGTQKGDVYSFAVVCQEIVYRNGPFYLEHME--MSPQDIYMKVKNGQKPFFRPTLGDEM-CPNDELAQLIRRCWAEDPIERPDFHSLKTAIRKLNREGDSGNILDNLLSRMEQYANNLEALVEERTADYLEQKRKAEDLLYLMLPKSVAMQLIRGDPVAAEWFDETTIYFSDICGFTSLSSESTPMEVVDLLNDLYTTFDTIIEKYDVYKVETIGDAYMVVSGLPVKNGNLHAREIARMSLSLLEAVLSFKIRHRPDMQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLRIHVSPKTKEILDSFGSFYLDLRGPVEMKGKGSVITHWLRGEKGQEDLME 1139
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 746.503 bits (1926), Expect = 0.000e+0 Identity = 429/1033 (41.53%), Postives = 623/1033 (60.31%), Query Frame = 2
Query: 353 LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQD-FQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGD----FISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVV-----AFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGE 3394
L+ + P +GP D+ ++ V L + +P++T G A+G + D + +T+T T + L L + F W + L +F D+ +G+ F E +Y L++ N ++++ +RP N+ ++L+++ + R++ +C P++ R +M + ++ FI D+ ++ + +P ++E+ KKAY+S+ I+T P++ +K F ++K +K + + V ++ F+D +++Y ALN+ L ++ ITE+M N++ G++G V ID +GDR D++L DM D + FQ+VA+ NG+ K+ + + W P D P CGF N + C +S ++ IL+I +++ IYR K EL A W I W+ ++ NL K++ G + R SN+ SL T G N Q+F+KT +K IVAIK + + K+IE+ + +L ++K ++D+ NDH+ RFIGAC++P ++ I++EYCP+GSLQD+LEN+ I LDW+FK+SLI DI +GM +LH S I HGNLKSSNC++D+RFV+K+TD+GL R D E+ +++Y LW AP++LR SN GT KGDIYSF IILQE+ R GVFY+ E ++ + P+EIV+RV RP + ++ H E+ ++++ W E P +RPE +IKV+ RK N+ S +ILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTSLSAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LHAREI+RMSLA L A+ TF+I HR D++L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNT+SRMESNG+ +KIH+S + D+L+ F F + RG +E+KGKG TYWL GE +
Sbjct: 118 LKFAHEPWAFIGPGCDYT-SSPVGLFTTHWGLPMITAGAPAVGFSDRSDAYTSITNTGPTHKKLGEFALHICRHFGWSQHA-----LLMF---GDSKMGERECYFAVEGLYTELKEVNITTVDLVFEED--SRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWE-----------------DMQMSNLEKVLRS---------------------------------AGSKLTLSLRGSNY--GSLLTADG-------NFQVFAKTAYFKGNIVAIKYV-NRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESD---PEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYI-EGDS-LSPKEIVDRVALGEWPYLRPTVNTQA--HSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESK 1069
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 746.503 bits (1926), Expect = 0.000e+0 Identity = 429/1033 (41.53%), Postives = 623/1033 (60.31%), Query Frame = 2
Query: 353 LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQD-FQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGD----FISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVV-----AFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGE 3394
L+ + P +GP D+ ++ V L + +P++T G A+G + D + +T+T T + L L + F W + L +F D+ +G+ F E +Y L++ N ++++ +RP N+ ++L+++ + R++ +C P++ R +M + ++ FI D+ ++ + +P ++E+ KKAY+S+ I+T P++ +K F ++K +K + + V ++ F+D +++Y ALN+ L ++ ITE+M N++ G++G V ID +GDR D++L DM D + FQ+VA+ NG+ K+ + + W P D P CGF N + C +S ++ IL+I +++ IYR K EL A W I W+ ++ NL K++ G + R SN+ SL T G N Q+F+KT +K IVAIK + + K+IE+ + +L ++K ++D+ NDH+ RFIGAC++P ++ I++EYCP+GSLQD+LEN+ I LDW+FK+SLI DI +GM +LH S I HGNLKSSNC++D+RFV+K+TD+GL R D E+ +++Y LW AP++LR SN GT KGDIYSF IILQE+ R GVFY+ E ++ + P+EIV+RV RP + ++ H E+ ++++ W E P +RPE +IKV+ RK N+ S +ILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTSLSAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LHAREI+RMSLA L A+ TF+I HR D++L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNT+SRMESNG+ +KIH+S + D+L+ F F + RG +E+KGKG TYWL GE +
Sbjct: 118 LKFAHEPWAFIGPGCDYT-SSPVGLFTTHWGLPMITAGAPAVGFSDRSDAYTSITNTGPTHKKLGEFALHICRHFGWSQHA-----LLMF---GDSKMGERECYFAVEGLYTELKEVNITTVDLVFEED--SRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWE-----------------DMQMSNLEKVLRS---------------------------------AGSKLTLSLRGSNY--GSLLTADG-------NFQVFAKTAYFKGNIVAIKYV-NRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESD---PEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYI-EGDS-LSPKEIVDRVALGEWPYLRPTVNTQA--HSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESK 1069
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 700.664 bits (1807), Expect = 0.000e+0 Identity = 414/1033 (40.08%), Postives = 603/1033 (58.37%), Query Frame = 2
Query: 353 LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQD-FQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGD----FISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVV-----AFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGE 3394
L+ + P +GP D+ ++ V L + +P++T G A+G + D + +T+T T + L L + F W + L +F D+ +G+ F E +Y L++ N ++++ +RP N+ ++L+++ + R++ +C P++ R +M + ++ FI D+ ++ + +P ++E+ KKAY+S+ I+T P++ +K F ++K +K + + V ++ F+D +++Y ALN+ L ++ ITE+M N++ G++G V ID +GDR D++L DM D + FQ+VA+ NG+ K+ + + W P D P CGF N + C +S ++ IL+I +++ IYR K EL A W I W+ ++ NL K++ G + R SN+ SL T G N Q+F+KT +K IVAIK + + K+IE+ + +L ++K ++D+ NDH+ RFIGAC++P ++ I++EYCP+GSLQD+LEN+ I LDW+FK+SLI DI +GM +LH S I HGNLKSSNC++D+RFV+K+TD+GL R D E+ +++Y LW AP++LR SN GT KGDIYSF IILQE+ R GVFY+ E ++ + P+EIV+RV RP + ++ H E+ ++++ W E P +RPE +IKV+ RK N+ S +ILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTSLSAESTPMQV ETIGDAY+VVSGLP RNG LHAREI+RMSLA L A+ TF+I HR D++L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNT+SRMESNG+ +KIH+S + D+L+ F F + RG +E+KGKG TYWL GE +
Sbjct: 137 LKFAHEPWAFIGPGCDYT-SSPVGLFTTHWGLPMITAGAPAVGFSDRSDAYTSITNTGPTHKKLGEFALHICRHFGWSQHA-----LLMF---GDSKMGERECYFAVEGLYTELKEVNITTVDLVFEED--SRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWE-----------------DMQMSNLEKVLRS---------------------------------AGSKLTLSLRGSNY--GSLLTADG-------NFQVFAKTAYFKGNIVAIKYV-NRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESD---PEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYI-EGDS-LSPKEIVDRVALGEWPYLRPTVNTQA--HSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNRE-VSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQV-----------------------ETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESK 1065
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666]) HSP 1 Score: 698.353 bits (1801), Expect = 0.000e+0 Identity = 428/1132 (37.81%), Postives = 646/1132 (57.07%), Query Frame = 2
Query: 71 LEMLLILSIVVFNYFINAENSKKHQMV-IGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKS---MSKSLWEIIDL-LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQD-FQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGD----FISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVV-----AFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGE 3394
+++LL + +V F++ ++ H+++ + +IL + N ++ PA+D A + + + L V ++ + S+S+ ++ + L+ + P +GP D+ ++ V L + +P++T G A+G + D + +T+T T + L L + F W + G D+ +G+ F E +Y L++ N ++++ +RP N+ ++L+++ + R++ +C P++ R +M + ++ FI D+ ++ + +P ++E+ KKAY+S+ I+T P++ +K F ++K +K + + V ++ F+D +++Y ALN+ L ++ ITE+M N++ G++G V ID +GDR D++L DM D + FQ+VA+ NG+ K+ + + W P D P CGF N + C +S ++ IL+I +++ IYR K EL A W I W+ ++ NL K++ G + R SN+ SL T G N Q+F+KT +K IVAIK + + K+IE+ + +L ++K ++D+ NDH+ RFIGAC++P ++ I++EYCP+GSL + GM +LH S I HGNLKSSNC++D+RFV+K+TD+GL R D E+ +++Y LW AP++LR SN GT KGDIYSF IILQE+ R GVFY+ E ++ + P+EIV+RV RP + ++ H E+ ++++ W E P +RPE +IKV+ RK N+ S +ILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTSLSAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LHAREI+RMSLA L A+ TF+I HR D++L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNT+SRMESNG+ +KIH+S + D+L+ F F + RG +E+KGKG TYWL GE +
Sbjct: 7 VKLLLQVGLVSFSH----RHNHNHEIIKLAVIL----PKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYT-SSPVGLFTTHWGLPMITAGAPAVGFSDRSDAYTSITNTGPTHKKLGEFALHICRHFGWSQHALLMFG--------DSKMGERECYFAVEGLYTELKEVNITTVDLVFEED--SRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWPG--GFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWE-----------------DMQMSNLEKVLRS---------------------------------AGSKLTLSLRGSNY--GSLLTADG-------NFQVFAKTAYFKGNIVAIKYV-NRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSL----------------------VLSGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESD---PEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYI-EGDS-LSPKEIVDRVALGEWPYLRPTVNTQA--HSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNRE-VSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESK 1027
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539]) HSP 1 Score: 625.165 bits (1611), Expect = 0.000e+0 Identity = 383/1000 (38.30%), Postives = 569/1000 (56.90%), Query Frame = 2
Query: 215 QIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKS---MSKSLWEIIDL-LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSK-----SLGSQDVSRFVVAFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSG 3160
++ PA++ A EK+ + + V + S S+ ++ + L+ + P +GP D+ + R + + VP++T G ALG + +T+T T + L ++ M F W +K + D +ND+ F E Y + N ++ + P ++ D + +S+ R++ +C K + R +M Y + +Y F D+ +S RP ++E K+A++S+ I+T P++ +K F ++K+ +K S+ ++ FHD VL+Y+HALN+ +D++ G +T++M N++ +G++G V +D NGDR D++L DM D ++ +++V++ N S K+ +++ W+ PP D P CGF N + C +S + I II V++ IYR K EL A W + W+ I+ + NL+K + C L + R SN+ SL TL G N Q+++KT YK I AIK + + K+IE+ + +L ++K ++D+ N+H+ RFIGAC++ ++CIL+EYCP+GSLQD++E + I LDW+F++SLI DI +GM +LH S I HGNLKSSNCL+DSRFV+K+TD+GL R K+ LE+ +A+Y LWTAPE++R+ N GT KGD+YSF IILQE+ GVFYL P P+EIVE V + R RP L +S H E+ ++++ W E +RP+ IKVM K N+ G NILDNLLSRMEQYANNLE LV +RT+ Y EEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT++SAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH EI+RMSLA L+A+++F+I HR D +L +RIG+H+G
Sbjct: 67 RVGPALNWALEKVNSDPTLLPGYHMQLVFSSSENKEGLCSDSVAPLVAVDLKFAHDPWAFIGPGCDYASSPVARFTT-HWEVPMVTAGAPALGFNM---YSSITNTGPTHKKLGEFVVRMHHNFGW----HKYAMVMFHDKKNDDRPCYFAVEGPYTEMTADNITAKDMVFNED--DEPLSYADLINGISQRGRVVYVCCKWDTFRKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPWARGDADDEAAKQAFKSVKIMTYREPQNPEYKHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYEIVSVYNSSAKQMVLEPGMKVHWLK--GSPPPDIPVCGFKNDNPACLAKTVTMHQMISIVACFIFIIIVTVTVFIYRKVKLENELAAQLWRVYWEDIQIS-----------------NLDKALRRACSRLTL---------------------------------SLRGSNY--GSLLTLEG-------NVQIYAKTCYYKGNITAIKYV-NKKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFR--KESYLEDT-HAYYARKLWTAPELMRDENRQPCGTQKGDVYSFGIILQELALLKGVFYLDS--PPFSPKEIVEHVAEGRWPYLRPLLCTQS--HSEELGQLMQRCWSEDVNERPDFNQIKVMLHKNNR-GYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTG 986
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006352.1 (pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 gene:ENSPMAG00000005587.1 transcript:ENSPMAT00000006352.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 721.465 bits (1861), Expect = 0.000e+0 Identity = 411/891 (46.13%), Postives = 560/891 (62.85%), Query Frame = 2
Query: 785 IIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDIL-------NKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSK---SLGSQDVSRFVVA--FHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDC---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQ-DVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGED 3397
++ C V R M A+ G GDY F D N S+S++PW + +E K+AY++++II+ P++ +K F ++K+++K + +D ++A F+D++++Y ALN L V DG IT+ M N++ G++G ID NGDR D+SL D+ D T F VV +G+ K V ++I W P D P CGF N C F L + +IL+I AV S +IYR K EL +M +W +L+ EN+ ++E + L GS S SL T G RN QMF+KTG Y+ +VAIKPI + KKIE+ + +L ++K ++D+ N+H+ RF+GAC++P ++CI++EYCP+GSLQ D+LEN+ I LDW+F++SLI DI +GM++LH S IG HG+LKSSNC++DSRFV+K+TD+GL R + E+ ++ Y LWTAPE+LR + +GT KGD+YS IILQEI RNG FY+ + + P+EIV++VK ++ FRP + H E+ ++++ W E P +RP+ IK++ KFNK +S NILDNLLSRMEQYANNLE LV +RT+ YLEEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTSLSAESTPMQV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG L+A+EI+RMSLA L A+ TF+I HRQ+ +L +RIG+H+GPVCAGVVGLKMPR+CLFGDTVNTASRMESNG+A+KIH+S+ T +VL FG F + RG +E+KGKG TYWL GE E+
Sbjct: 6 VVYFCCSAAVFRQTMVQAHAEGMTAGDYVFFYVDPFSESLSESNVSESRKPWK---RGDEFDEQAKEAYKAVMIISYREPQNIEYKDFVVKLKKRAKEQFNFTIEDTLMNLIAGSFYDAIMMYTAALNKTLSSGGGVHDGHAITKHMWNRTYRGVTGEFTIDRNGDRETDFSLWDLTDMNTGEFNVVLSYDGASSKLIEVPGLEIQWPG--GSIPKDVPLCGFENEACISGGFSTMEVLMIVFSLILLIVAVSSFLIYRKLKLEKELASM----LW------------------RLRWENIQV--------------------SSLEKARRSAGSKLTLSMRGS----------SCGSLLTTQG------RN-QMFAKTGYYRGNLVAIKPI-NKKKIELTREVLFELKHMRDVLNEHLTRFVGACIDPPNICIVTEYCPRGSLQQDILENESITLDWVFRYSLINDIVKGMLFLHNSVIGSHGSLKSSNCVVDSRFVLKITDYGLASFRSCSEC---EDMHSLYAKKLWTAPELLRLEHPPPQGTQKGDVYSLGIILQEIALRNGTFYVEGMD--LSPKEIVQKVKNGQRPYFRP--STDESCHIEELGLLMQRCWAEDPAERPDFSQIKMLIHKFNKE-NSTNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAETLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLNAKEIARMSLALLDAVKTFKIRHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWLLGEIEE 823
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943]) HSP 1 Score: 569.696 bits (1467), Expect = 0.000e+0 Identity = 275/503 (54.67%), Postives = 368/503 (73.16%), Query Frame = 2
Query: 1901 PIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSN-IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGD------SGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
P ++ KKIE+ + +L ++K ++D+ N+H+ RF+GAC++ ++CI++EYCP+GSLQD+LEN+ I LDW+F++SL+ DI +GM+YLHS+ IG HGNLKSSNC++DSRFV+K+TD+GL +R H ++ ++ LWTAPE+LR GT KGD+YSFAIILQEI R+G FYL + +EIV+RVK RP + + H E+ ++++ W E +RP+ IK++ +KF+ D + ILDNLLSRMEQYANNLE LV +RT+ YLEEK KAE LLY +LP SVA QL R E V AE+++SVTIY SDIVGFT++SA+STPMQV+ LN LYT FD+I++N+DVYKVETIGDAY+VVSGLP NG HA E++RM+LA L A+ F I HR +RL +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRME+ G+A +IH+S T +L +G F++ G +++KGKG TYWL GE
Sbjct: 8 PFINRKKIELTRQMLFELKHMRDVQNEHLTRFVGACIDVPNICIITEYCPRGSLQDILENESISLDWMFRYSLMHDIVKGMLYLHSSVIGSHGNLKSSNCVVDSRFVLKITDYGLSSVRA---HSKADSSANYFEKRLWTAPELLRLEEVAPRGTQKGDVYSFAIILQEIALRSGPFYLEA--NHLTAKEIVQRVKLGEWPYLRPTV--DPGGHSEELGHLMQRCWAEESTERPDFHQIKILLQKFSSQDDGPESPPAFTILDNLLSRMEQYANNLEELVEERTQAYLEEKGKAEALLYQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVHNGTRHAIEVARMALALLSAVRCFHIRHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLGE 503
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008976.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008976.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 439.499 bits (1129), Expect = 7.676e-140 Identity = 245/518 (47.30%), Postives = 338/518 (65.25%), Query Frame = 2
Query: 1868 GVYKNGIVAIKPI--MHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLR-GSKDHLLE-ENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETP-----IEPQEIVERVKQFRQIP-FRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
G+Y+ VA+K + H ++ N+ L K++++ ++++ F G C+E ++CI+++YC KGSL+DVL+ +LDW+FK S DI GMI+LH S I HGNLK S CL+DSR +KLT FG+ + R G K L+ N +F+ L WTAPE+LR + V GT KGD++SFAI+++E+IY E E P +EP++I+++V+ +P RP L + E I ++I+Q W+E +RP+ ++ M R + GD NILDN++S++E+YAN+LE +V RT Q EK+K + LL +LP V QL + V E YE VTI+F DIVGFT++SA STP++VI LLN LY D I++ YDVYKVETIGDAY+V SGLP RNG H EI+ MSL FL ++ F+I H +L +RIG++SGPV AGVVG MPRYCLFGDTVN ASRMES G + IH+S T ++LK G + + ERG I LKGKG Q TYWL G+
Sbjct: 215 GIYQGNQVALKFLERTHPPDLKSNRFAL----KMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINNLGSFFIELYWTAPELLRMEDLPVNGTPKGDVFSFAILMREVIYH-------EDEGPYVGIHLEPKDIIDQVRDGIAVPPLRPLLTERCE---PRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGDM-NILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 717 HSP 2 Score: 53.5286 bits (127), Expect = 2.694e-7 Identity = 34/119 (28.57%), Postives = 56/119 (47.06%), Query Frame = 2
Query: 1094 FHDSVLIYAHALNDCLDK--NVSDGDHITEQMKNKS---INGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANV----QIDWVNVNNRPPLDTPKCGFSNTDC 1423
HD+ ++YA A+ + L + N DG + ++ + G SG V ID NG+R DY++ D+ K + I + F + ++ W + RPP D P+CGF+ C
Sbjct: 4 LHDAGILYAMAVRELLRQGGNPRDGRAVIRTIRGSNKIKFYGASGQVSIDVNGERFLDYAVFDLQKKQTATGEMRIASKRYFTFQTINFTPEYQKMGW--PDGRPPSDMPECGFTGELC 120
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008942.1 (pep scaffold:Pmarinus_7.0:GL476454:59555:94399:-1 gene:ENSPMAG00000008084.1 transcript:ENSPMAT00000008942.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 439.884 bits (1130), Expect = 4.271e-136 Identity = 239/518 (46.14%), Postives = 347/518 (66.99%), Query Frame = 2
Query: 1850 QMFSKTGVYKNGIVAIKPIMHTKKIEI-NKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLR-GSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYR-NGVFYLGEFETPIEPQEIVERVKQFR-QIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
+MF+ G+Y+ VA+K + T+ ++ +K+LL +++ +++L ++++ F G C+E ++CI+++YC KGSL+DVL+ +LD +FK S DI GMI+LH S I HGNLK S CL+DSR +KLT FG+ + R G K +++ N L WT+PE+LR V GT KGD++SF ++++E+IY + Y+G +EP+EI+++V++ + P RP L + E I ++I++ W+E P +RP+ +I M R + G +ILDN++S++E+YAN+LE +V RT Q EK+K + LL +LP V QL + V E +E VTI+F DIVGFT++SA S+P++VI LLN LY D I++ YDVYKVETIGDAY+V SGLP RNG H EIS MSL FL ++ F+I H +L +RIG++SG V AGVVG MPRYCLFGDTVN ASRMES G ++IH+S +T +LK+ G + + ERG I+LKGKG Q TYWL+G+
Sbjct: 543 KMFTPLGIYQGNQVALKFLQRTRPPDLKSKTLLKELQMLRELRHENLVVFFGVCVEMPNICIVTQYCRKGSLKDVLKTSDFELDLMFKTSFAYDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRHGKKGKIMDVNNQDI-AELFWTSPELLRMEIFPVNGTPKGDVFSFGVLMREMIYHEDEGPYVG---VDMEPKEIIDQVREGKCSPPLRPLLTERCE---PRIQALIQRCWDESPDRRPDFHSIARMLRSASPEGHR-SILDNMVSKLEKYANHLEEVVEDRTAQLESEKKKTDRLLSSLLPSVVVEQLKAGKTVQPEHFEQVTIFFCDIVGFTAMSAISSPLEVITLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEISIMSLHFLSSIINFRIRHLPKEQLKIRIGVNSGSVVAGVVGNTMPRYCLFGDTVNVASRMESTGYPLRIHVSESTASLLKSIGGYELVERGAIQLKGKGSQLTYWLNGK 1052 HSP 2 Score: 85.5001 bits (210), Expect = 4.598e-17 Identity = 65/244 (26.64%), Postives = 113/244 (46.31%), Query Frame = 2
Query: 746 HKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQK-------SKSLGSQDVSRFVVAFHDSVLIYAHALNDCL--DKNVSDGDHITEQMKNKS---INGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIV-----NGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCN 1426
H+ NL ++S +RI+IL E R+++ A LG G + F+ S W S + + L+ A +++ T+ S++++ F +EV+++ S ++VS + HD+ ++YA A+ + L N DG I +K + G+SG V+ID NG+R DY++ ++ K + Q + ++ GS F+P + W PP D P CGF C
Sbjct: 203 HRQNLLDISTKARIVILICGSEEAREVLLEAQSLGLATGKFIFLVVQQFEDSF----WKSVAAERLDTQTLQ-ALEPVMLFTIKAYGSSDYELFLQEVRRRLLGPPFYSNLSSDKEVSPYAAYLHDAAILYAMAVRELLRHGGNPRDGRAIVRTIKGSTKVKFYGVSGQVNIDVNGERFLDYAVFNLQKKGNSSQFLPVMVFDTFQGS-ISFTPEYQKMV-W--PEGGPPNDMPICGFLGELCQ 437
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002650.1 (pep scaffold:Pmarinus_7.0:GL478983:4063:28109:1 gene:ENSPMAG00000002416.1 transcript:ENSPMAT00000002650.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 416.387 bits (1069), Expect = 5.072e-134 Identity = 224/505 (44.36%), Postives = 316/505 (62.57%), Query Frame = 2
Query: 1889 VAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEF------ETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHG 3385
VA+K I K + K + +VK+V++L ++C+FIG +E ++ IL+EYCPKGSLQDVL ND I L+W F+FS DI RGM +LHS+ HG LKS+NC+ID R+V K+ D+GL++ R KD L E ++ ++ PE + + N+ E D+YS+ +IL EI R G + ET P ++ F R +G + +I++ W PL RP IK K N + + +D ++S ME+Y+ +LE +VT+RT+ + EK+K + LLY MLPK +A L + A+SY S T++FSDIVGFT LS+ STP +V++ LN LYT+FD I++NYDVYKVETIGDAY+VVSG+P N N HA E + M+L + F IPH+ + +L +R G+H+GPV AGVVG KMPRYCLFGDTVNTASRMES +A+KI S +T +L+ GS++++ RG + +KGKG T+WL G
Sbjct: 4 VALKKI-EKKAFNLTKVIRREVKQVRELEYANLCKFIGGMVEVPNVAILTEYCPKGSLQDVLLNDDIPLNWGFRFSFATDIARGMAFLHSHRLFHGRLKSTNCVIDDRWVCKIADYGLEEYR--KDDLAEYATTHKPKSWVYLPPERIVSKNT--EPAPTTDVYSYGVILVEIATRQTPTPAGLYSPHDDAETEGPPPSPPPPIRPFIYKSVRCTIGS-----AYYYNKLIQKCWNHNPLLRPTFEQIKKFLHKMNP--NKFSPVDMMMSLMEKYSKHLESVVTERTQDLVLEKQKTDRLLYSMLPKQIADDLRQGRVTKAQSYASATVFFSDIVGFTQLSSSSTPYEVVDFLNKLYTSFDGIIDNYDVYKVETIGDAYMVVSGVPTENHNQHAVETANMALDLVNVCQAFVIPHKPEMQLKIRAGIHTGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSEALKIQCSPSTSSILQQIGSYLLSCRGTVTVKGKGEMITWWLEG 496
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 76.6406 bits (187), Expect = 1.506e-14 Identity = 60/243 (24.69%), Postives = 109/243 (44.86%), Query Frame = 2
Query: 1874 YKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRN---------GVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMW 2575
+ + +VAIK +++ E+N ++ ++ +K+LN+++I ++ G + + IL EYC GSL+ ++ L + + G+ YLH H ++K++N L+ + VKL DFG+ + S + L W APEIL N + DI+S + E++ +N ++Y E +T P E +K F F + K D ++K +W
Sbjct: 46 HTDQVVAIKEVVYENDEELN-DIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNS-------SALTLAGTLNWMAPEILGNRG----ASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKR-----PTADQLLKHVW 271
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354]) HSP 1 Score: 69.3218 bits (168), Expect = 2.064e-12 Identity = 54/196 (27.55%), Postives = 93/196 (47.45%), Query Frame = 2
Query: 1961 VKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICR----GMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIY----------RNGVFYLGEFETPIEPQEIVERVKQFRQIPF 2506
+K+L++++I + GA E ++ I EY P GS+ +L N F+ SLI + R G+ YLH H ++K +N LID + VK+TDFG+ K + S + + + ++ W +PE+++ + + T K DI+S ++ E+ +F +G TP P K F + F
Sbjct: 508 LKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNY-----GPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISK-KLSPLNKKQNKRASLQGSVFWMSPEVVKQTAT----TAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFKIGTNTTPEIPSWATSEGKNFLRKAF 693
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529]) HSP 1 Score: 69.707 bits (169), Expect = 2.083e-12 Identity = 49/162 (30.25%), Postives = 81/162 (50.00%), Query Frame = 2
Query: 1916 KKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQD-VLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIIL 2398
K+I +K + + + L + HICR C H +L EY G L D ++++ I+ KF+ + I +IYLH+N H +LK N +I +K+ DFGL + S+ L + F +L + APE+L+ +N V D++SF ++L
Sbjct: 183 KEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFA--RGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQL-----HTFCGSLYFAAPELLK-ANPYTGPEV--DVWSFGVVL 334
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 67.3958 bits (163), Expect = 8.503e-12 Identity = 58/227 (25.55%), Postives = 105/227 (46.26%), Query Frame = 2
Query: 1934 KSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNI 2614
K LL +++ K +++ +I +FI + ++ IL E CP GSL ++L+ ++ + +F Q IC + Y+HS H +LK N DS + +K+ DFGL + ++ E Y + APE+L +S + + DI+S ++L ++ F + T I ER+K R + + E +I+ + P++RP + I
Sbjct: 124 KKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQ-ICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANE----SERKYTICGTPNYIAPEVLMGKHS--GHSFEVDIWSLGVMLYALLIGKPPFQARDVNT------IYERIK------CRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEI 331
BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086]) HSP 1 Score: 63.1586 bits (152), Expect = 2.527e-10 Identity = 49/162 (30.25%), Postives = 79/162 (48.77%), Query Frame = 2
Query: 1916 KKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQD-VLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIIL 2398
K+I +K + + + L + HICR C H +L EY G L D ++++ +K KF+ + I + YLH+N H +LK N +I S +K+ DFGL + + L + F +L + APE+L+ + V DI+SF I+L
Sbjct: 162 KEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFA--RGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQL-----HTFCGSLYFAAPELLK-AQPYTGPEV--DIWSFGIVL 313
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO34275 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SPS9]) HSP 1 Score: 540.806 bits (1392), Expect = 0.000e+0 Identity = 272/521 (52.21%), Postives = 370/521 (71.02%), Query Frame = 2
Query: 1835 NLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSN-IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGK---ESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHG 3385
N+ Q+F+ G+YK+ +VAIK I + ++IE+ + + ++K ++ + ++++ F GAC+EP ++CIL +YCPKGSLQD+LEN+ IKLD +F SL+ DI +GM YLHS I HG LKS NC++D R+V+K+TD+GL K + ++D EE YA Y LWTAPE+LR ++ GT KGD+YSF II+QE++ R+G F L + EP +I+E+V + PFRP L E +D + K WEE P RP+ I+ RK G NI+DN+++ +E+YANNLE LV +RT Q +EKRK E+LL MLP SVA+ L+ + VTAE+++ V+I+FSDIVGFTSLS+ESTP+QV++LLN LYT FD I+ NYDVYKVETIGDAY+VVSGLP RNG+ HA EI+ M+L L+ + +F+I HR + +L +RIG+HSG AGVVG KMPRYCLFGDTVNTASRMESNG+A+KIHIS +T +L G + I +RG++ LKGKG TYWL G
Sbjct: 1 NINQRQIFTTVGIYKSNMVAIKRI-NKRQIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPKGSLQDILENEDIKLDSMFVNSLLTDIVKGMAYLHSTEIRSHGRLKSPNCVVDGRWVLKITDYGLNKFKSNQDISEEEGEYAMYYRKLWTAPELLRAADPRPRGTQKGDVYSFGIIVQELLTRSGPFDLSYYTN--EPSDIIEKVTRVESPPFRPKLSTIVLEGPTVAGIVD-LAKWCWEENPDHRPDFEEIRKTVRKL-PMGKQSNIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTENLLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVG 516
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO30985 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SZ80]) HSP 1 Score: 514.612 bits (1324), Expect = 1.405e-170 Identity = 258/492 (52.44%), Postives = 354/492 (71.95%), Query Frame = 2
Query: 1916 KKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRG-SKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKF-NKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKAL-FTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWL 3379
+ I+I++ LL+++K+++D+ +D++ +FIGAC+ P ++CI+ +YC +GSLQD+LEND +KLD +F SL+ DI +GM YLH S+I HGNLKSSNCL+DSR+V+K+TD+GL LR SK +E N +R+LLW APEILR + +GT KGD+YSF+IILQE R+G + +EP+ I+E+V++ P+RP + + E+ ++KQ W E P RP+ IK R+ +K+G NI DN+++ ME YA+NLE LV QRT+Q ++EKRK + LL +LP+ VA QL + + V AES+ VTIYFSDIVGFTSLSAESTPMQV+ LN LYT FD I++ YDVYKVETIGDAY+V SGLP RNG HA EI++M+L + A+ F + H+ + +L +R+G H+GPV AGVVG M RYCLFGDTVNTASRMESNG+ ++IHIS+ T DVL G+F++ RG++ LKGKG T+WL
Sbjct: 11 RTIDISRQLLLEMKQMRDIRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDLVFIASLLSDIVKGMEYLHNSDIRSHGNLKSSNCLVDSRWVLKITDYGLPLLRSRSKKSTIETN----WRDLLWVAPEILRIPSRPPKGTHKGDVYSFSIILQEFHTRDGPYSANY----MEPKAIIEKVRKSEFPPYRPIVANLIDG-AEELRDLMKQCWAEDPDLRPDFTEIKKTVRRIVDKSGMKKNIFDNMVNMMEIYADNLENLVAQRTDQLVDEKRKTDALLESILPRPVAEQLKKGKAVEAESFNEVTIYFSDIVGFTSLSAESTPMQVVTFLNDLYTIFDDIIQEYDVYKVETIGDAYMVASGLPIRNGRRHAGEIAKMALHLVDAVSHNFIVRHKPEYKLQLRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWL 493
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36203 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA1]) HSP 1 Score: 433.721 bits (1114), Expect = 4.452e-140 Identity = 223/469 (47.55%), Postives = 308/469 (65.67%), Query Frame = 2
Query: 1856 FSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEG--TVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG 3253
F + K+ +VA+K ++ + + + +LI++K+V+D+ + ++ +IG C P ++CI+S+YC +GSLQ++L ND+I LDW F+ S DI GM +H S+I HG+L+SS CLIDSR+V K+ DFGL L+ ++ E +A Y L W APE+L+N S + T GD+YSF IIL E++ R + EF P E++ER++ PFRP E N + ++ Q W + P RP +IK R G +I+DN+L ME Y LE +V +RT Q +EK K ++LLY MLP+ +A L R EPV AESY SVTI+FSDIVGFT L+A STP+QV++LLN LYT FD+I++ +DVYKVETIGDAY+VVSGLP RNG+ HA EI+ M+L L ++ F+ H +R +H+RIG+H+G AGVVGLKMPRYCLFGDTVN ASRMES G
Sbjct: 59 FCEHSFIKSYLVALK-MLRKDSLTLTRDMLIEMKQVRDVQHTNLLHYIGVCTTPPNICIVSQYCHRGSLQEILANDEISLDWFFRESFANDIAMGMHVIHTSSIHVHGDLRSSKCLIDSRWVCKVADFGLNLLKANQRPDPEIGVHAQYSRLFWRAPELLQNEKSTNKPVPTQMGDVYSFGIILNELLTREEPYATTEFA----PIEVIERIRCHLNPPFRPETPFEIRNRS--VTKLMTQCWNDDPQARPTFSDIKRQLRLLK--GGKSSIVDNMLRLMENYTEQLETIVDERTRQLADEKAKTDELLYKMLPRYIAESLKRGEPVIAESYSSVTIFFSDIVGFTELAAASTPLQVVDLLNDLYTCFDTIIDKHDVYKVETIGDAYMVVSGLPVRNGHRHAGEIATMALNLLSSMGNFRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGDTVNYASRMESTG 518
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36182 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA4]) HSP 1 Score: 416.387 bits (1069), Expect = 7.244e-134 Identity = 221/495 (44.65%), Postives = 317/495 (64.04%), Query Frame = 2
Query: 1952 VKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVE---GTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGK-ESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPE 3421
+K V+DL++ ++ R++G C+E ++C++S +C +G+LQD+L ND IKLDW+F+ S DI GM +H S I HGNLKSSNCLIDSR+ K+TD+GL LR ++ + +A Y+NL WTAPE+L ++ + T GD+YS+ I+L EII R+ + + ++++E V++ ++ FRP K E G ++ + + W+ +RP IK +K G + + SR Y NN LV R + KR L+L + +A +L + V+AES++SVTI+FSDIVGFTS++A+STP+QV++LLN LYT FD +++ +DVYKVETIGDAY+VVSGLP RNG HA E++ M+L L + FQIPH R++ +RIG+HSG AGVVGLKMPRYCLFGDTVN ASRMES+G A++IH+S +VL G + + ERG + +KGKG TY+L G+D D LP+
Sbjct: 1 MKMVRDLHHANLNRYLGVCVESPNICMVSRFCNRGTLQDLLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPK-DIGEFAVYKNLFWTAPELLPLADGFKDRKNKTQAGDVYSYGIVLYEIITRDEPYSTNT--DTLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIK---KKLKANGMGNGKISGMFSR---YYNNFSKLVISRMGVCMALKR------LLVLSRPIADELKKGNSVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMKGKGTIVTYFL--TGKDGFDKPLPD 478
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36204 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA3]) HSP 1 Score: 411.379 bits (1056), Expect = 5.787e-132 Identity = 236/501 (47.11%), Postives = 304/501 (60.68%), Query Frame = 2
Query: 1961 VKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGM-----------HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEAS 3427
V L++ +I +IG C+ ++CI+SE C +GSL DVL ND IKLDW FK S DI GM LH S + HGNL SSNCL+D +V K+ D+GLQ+ + EE LW APE +RN++S G+ GD+YSF +IL EI+ R FET I+ R+ P RP L +++ I IKQ W E P RP R+IK RK N G S ++D++L +M+ Y+NNLE LV +RT Q EK K + LLY MLP+ VA QL + V AE ++ VT++FSDIVGFT LS+ STP+QV+ LN LYT FD+I+ NYDVYKVETIGDAY+VVSGLP++N + HA EI+ M+L L + TF+I H D RL + SGP AGVVG+K PRY +FGDTVN ASRMESNG +IHIS L G + + RG+IELKGKG TY+L+ G+D + V PE S
Sbjct: 2 VHKLSHVNINPYIGVCITAPNICIVSEACGRGSLADVLINDDIKLDWTFKMSFATDIAAGMEALHASEVSFHGNLTSSNCLVDRMWVCKIADYGLQRF-SKHTYEPEEQLTGQTGKSLWMAPEHMRNASS--TGSQPGDVYSFGVILSEIVTR-----CEPFETLRATTSILRRIMSTEFPPLRPTL--NADDCDPTITKFIKQCWSEEPSARPTFRDIKKSMRKIN-GGRSLRLVDSMLGKMDIYSNNLEVLVEERTRQLEAEKAKTDQLLYEMLPRPVADQLKSGKSVEAELFDQVTVFFSDIVGFTKLSSSSTPIQVVTFLNDLYTYFDNIIPNYDVYKVETIGDAYMVVSGLPEKNRDRHAGEIATMALHLLCDIRTFKIRHVPDTRLVSSYSLLLIITCLFYLIFSGPAVAGVVGIKKPRYDVFGDTVNVASRMESNGVPNRIHISAECRKALLNLGGYHMERRGEIELKGKGKVITYFLN--GKDGFNRVRPEPS 489
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc2 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125799]) HSP 1 Score: 748.814 bits (1932), Expect = 0.000e+0 Identity = 443/1080 (41.02%), Postives = 640/1080 (59.26%), Query Frame = 2
Query: 215 QIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKS---MSKSLWEIIDL-LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPP-NHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQS-QRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKS---LGSQDVSRFVVA--FHDSVLIYAHALNDC--LDKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGE 3394
+I PA++ A KI N L V K+ S S+S+ ++ + L+ + +P +GP + A+ V L + VPL+T G A+ + +T+T T + L L + + F W R Y V L D + D+ F E +Y+ L+ N + ++++ +PP N+ L ++ R++ +C P+V R +M + Y F+ D+ S S ++PW Q++ I K A++S+ I++ P++ ++ F ++K +K+ QD ++A F+D +++YAHALN+ + G I+ +M N++ +G++G +H+D +GDR D++L D+ D + +FQ+V + N +++ +PV + W+ PLD PKCGF N + C +S L I + ++I I R K EL A W I WD I+ M+N D L G + R SN+ SL T G N Q+F+KTG YK IVAIK + K+IE+N+ +L ++K ++D+ N+H+ RFIGAC++P ++CI++EYCP+GSLQD+LEND I L+W+FKFSLI DI +GM++LH S I HG LKSSNC++D+RFV+K+TD+GL R D + + +++Y LW APE+LR N +GT KGD+YSF+IILQE+ R G FYL P+ P+EIV+RV RP + +S H E+ ++++ W E P +RP+ +I+++ RK NK + NILDNLLSRMEQYANNLE LV +RT+ Y EEKRKAE LLY +LP SVA QL R E V AE+++SV+IYFSDIVGFT+LSAESTPM+V+ LLN LYT FD++++N+DVYKVETIGDAY+VVSGLP RNG LH REI+RM+LA L + TF+I HR +++L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNT+SRMES+G+A+KIH+S T DVL F SF + RG I++KGKG TTYWL GE +
Sbjct: 64 RIGPALERAIIKINSDPNLLPNHHLTYVFKSSENSNGICSESVAPLVAVDLEFAYKPWAFIGPGCSYT-ASPVGLFTTHWDVPLITAGAPAIAFLDGI-YPTITNTGPTHKKLGRFALRICEHFGW--REY--VTLMFSDNKEDDRPCYFAMEGLYEELKSINISLQDSVFEEN---KPPINYSQILADIQNIGRVMFVCCSPDVFRRLMIEFWKADLPHEQYVFLYIDLFAVSLSNKQPW---ARGDQDDTIAKDAFQSVKILSYREPQNQEYQQFVRDLKADAKTSFNYSVQDSLMNIIAGGFYDGLMLYAHALNETALVPGARPPGKLISGKMWNRTFHGVTGLLHLDVSGDRETDFALWDLVDTNSSSFQIVVVYNSFEEQVTPVPGTSVRWLG--GARPLDVPKCGFKNDNPACLTKTITIHQMVSITLFFIFTMTLTIAIFICRKMKLEKELVAQLWRISWDDIQ---------------------------------------------------MSNLDKVLRSGSRITLSLRGSNY--GSLMTANG-------NLQVFAKTGYYKGNIVAIK-YTNKKRIELNRKVLFELKHMRDVQNEHLTRFIGACVDPPNICIITEYCPRGSLQDILENDSITLEWMFKFSLINDIVKGMVFLHNSVIFSHGKLKSSNCVVDNRFVLKITDYGLSTFRQESD--VGSDSHSYYAQKLWMAPELLRMENPPPQGTQKGDVYSFSIILQEVALRRGAFYLDG--DPLSPKEIVDRVILGDWPCLRPSIDPQS--HSPELGQLMQRCWAEEPTERPDFNHIRLLLRKHNKESRT-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVSIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMALALLDTVRTFRIRHRPEQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGESD 1061
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819]) HSP 1 Score: 719.153 bits (1855), Expect = 0.000e+0 Identity = 423/1038 (40.75%), Postives = 616/1038 (59.34%), Query Frame = 2
Query: 353 LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNN--LGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDI----LNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGS---QDVSRFVVA--FHDSVLIYAHALNDCLDK--------NVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
L+ S P +GP D++ + R + + VP++T G A G K F +T+T T + L L + + F W + + L D ++DN+ F E +Y + N + + + NHK+ ++ + KN R++ LC + +R +M + G +Y F D+ L + PW+ Q++ + A+RS+ ++T P++ + F E +K+ ++ + + +D ++A F+D V++Y+ ALN+ L K GD +T++M N++ G+ G V +D GDR D++L DM D + F+VV + N S K+ + W PPL+ P+CGF N + C ++ ++ + +I ++I IYR K EL A W + W V ++ NL+K++ C + K SN+ SL T+ G N Q+++KTG YK +VAIK I + K+IE+ +++L ++K ++D++N+H+ RFIGAC++P +MCI++EYCP+GSLQD++E++ + LDW+F++SLI DI +GM +LH S I HGNLKSSNC++DSRFV+K+TD+GLQ LR S ++ +A+Y LWTAPE+LR + + GT KGD+YSF IILQE+ GVFY+ + T I P+EI++ V + RP L S H E+ ++++ W E P +RP+ IK++ RK ++ G NILDNLLSRMEQYANNLE LV +RT+ Y EEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTP+QV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH RE++RM+LA L A+ +F+I HR ++L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMES G+A+KIH+S T VL+ F +F + RG+IE+KGKG TYWL GE
Sbjct: 99 LKLSHDPWAFIGPGCDYSSSPVARFTT-HWDVPMVTAGARADGFSK---FAAVTNTGPTHKKLGEFSLKIQETFGW----HHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDYFVESNI-----NHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWF---RGDQDDHAARLAFRSVKVLTYMEPQNAEYHQFVETLKKDAEKMFNFTIKDSLYNLIAGGFYDGVMLYSRALNETLSKRKPGLRPVQRPKGDMVTQRMWNRTFQGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVVCVYNSSIKELVLQKGLNFQWPG--GSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSW-----------------VDIQMSNLDKVLRRACSRLTISMKG---------------------------------SNYG--SLMTMEG-------NLQIYTKTGYYKGNLVAIKYI-NKKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSS---CPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYI-DTHTLI-PKEIIQGVIRGGVPLLRPSLCFHS--HSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHR-GYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGE 1050
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183]) HSP 1 Score: 716.072 bits (1847), Expect = 0.000e+0 Identity = 422/1030 (40.97%), Postives = 609/1030 (59.13%), Query Frame = 2
Query: 365 TRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLREL----SKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQR-PWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSK-----SLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CNFGFAXXXXXXXXXXXXXXX--XXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDI 3400
+RP V GP + +A+ R +++PL+T GG A G K +++ + + L + + +F W R+ + +D++ D+ F+SE ++ L+D ++ARP ++ + +EL +N RII +C E IMK YA D+ +S + R PW N+ + + ++S+ +IT P++ +K F ++ +++ +L + +F+D ++YA AL++ L + + +G +IT + +N+S G++G V ID RN D L M + +T + VV+ NGS K+ +I W + PPLD P C FS D CN G + + L + + S +IYR K EL M W + W+ L+ E+ NK ++ + L Q GS S SL T G +Q+F+KTG +K +VAIK + + K+IE+ + +L+++K ++D+ +H+ RFIGAC++P ++CI++EYCP+GSLQD+LEN+ I LDW+F++SLI DI +GM +LH S G HGNLKSSNC++DSRFV+K+TD+GL R S ++ ++ +A Y LWTAPE+L + +GT KGD+YSF IILQEI RNG FY+ + + P+EIV++V+ ++ FRP +S H E+ +++ W E P +RP+ +IK+ K NK G S +IL+NLLSRMEQYANNLE LV +RT+ YLEEKRKAE+LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTS+SAESTP+QV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LHAREI+ MSLA L+ + TF+I HR + +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIH+S T +VL F F + RG +E+KGKG TYWL GE D+
Sbjct: 109 SRPDVFFGPGCVYPLASVGRFVS-HWKLPLITAGGPAYGFEKLDEYKTIVRIGPSTTKLGAFVNVLHTQFNWTSRAV----VIFYDLKQDDRPHYFLSEGIFMNLKDE--------MNMTVSARPYTNEQDYKELVSFIKENGRIIYICGPLETFLSIMKLFQSEIQDPESYAIFYLDVFAESLTHRKPWQ---NAKFDWTNPIQVFKSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCG--PPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRVQWE-----------------DLQFESPNK-------------------------YHKRAGSRLTLSQRGS----------SYGSLITAQG-------KYQLFAKTGYFKGNLVAIKHV-NKKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEN---DDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMD--LSPKEIVQKVRNGQRPYFRP--TTDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEG-STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKTDV 1052
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183]) HSP 1 Score: 663.685 bits (1711), Expect = 0.000e+0 Identity = 381/861 (44.25%), Postives = 534/861 (62.02%), Query Frame = 2
Query: 884 DILNKSQSQRPWYSPLNSTQENEILKKAYRS---------LLIITLTLPESNNFKSFSEEVKQKSK-----SLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--CNFGFAXXXXXXXXXXXXXXX--XXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDI 3400
D +N + S RP+ + + + +K+ RS + +IT P++ +K F ++ +++ +L + +F+D ++YA AL++ L + + +G +IT + +N+S G++G V ID RN D L M + +T + VV+ NGS K+ +I W + PPLD P C FS D CN G + + L + + S +IYR K EL M W + W+ L+ E+ NK ++ + L Q GS S SL T G +Q+F+KTG +K +VAIK + + K+IE+ + +L+++K ++D+ +H+ RFIGAC++P ++CI++EYCP+GSLQD+LEN+ I LDW+F++SLI DI +GM +LH S G HGNLKSSNC++DSRFV+K+TD+GL R S ++ ++ +A Y LWTAPE+L + +GT KGD+YSF IILQEI RNG FY+ + + P+EIV++V+ ++ FRP +S H E+ +++ W E P +RP+ +IK+ K NK G S +IL+NLLSRMEQYANNLE LV +RT+ YLEEKRKAE+LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFTS+SAESTP+QV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LHAREI+ MSLA L+ + TF+I HR + +L +RIG+H+GPVCAGVVGLKMPRYCLFGDTVNTASRMESNG+A+KIH+S T +VL F F + RG +E+KGKG TYWL GE D+
Sbjct: 210 DEMNMTVSARPYTNEQDYKELVSFIKENGRSKFTHQYDTSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCG--PPLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRVQWE-----------------DLQFESPNK-------------------------YHKRAGSRLTLSQRGS----------SYGSLITAQG-------KYQLFAKTGYFKGNLVAIKHV-NKKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEN---DDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMD--LSPKEIVQKVRNGQRPYFRP--TTDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEG-STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKTDV 1000
BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819]) HSP 1 Score: 658.292 bits (1697), Expect = 0.000e+0 Identity = 406/1025 (39.61%), Postives = 581/1025 (56.68%), Query Frame = 2
Query: 353 LQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNN--LGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDI----LNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDM-DPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTD--C---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLH-SNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGE 3388
L+ S P +GP D++ + R + + VP++T G A G K F +T+T T + L L + + F W + + L D ++DN+ F E +Y + N + + + NHK+ ++ + KN R++ LC + +R +M + G +Y F D+ L + PW+ Q++ + A+R + + F SFS V S ++ Q + + +E + G+ G V +D GDR D++L DM D + F+V + G + W PPL+ P+CGF N + C ++ ++ + +I ++I IYR K EL A W + W V ++ NL+K++ C + K SN+ SL T+ G N Q+++KTG YK +VAIK I + K+IE+ +++L ++K ++D++N+H+ RFIGAC++P +MCI++EYCP+GSLQD++E++ + LDW+F++SLI DI +GM +LH S I HGNLKSSNC++DSRFV+K+TD+GLQ LR S ++ +A+Y LWTAPE+LR + + GT KGD+YSF IILQE+ GVFY+ + T I P+EI++ V + RP L S H E+ ++++ W E P +RP+ IK++ RK ++ G NILDNLLSRMEQYANNLE LV +RT+ Y EEKRKAE LLY +LP SVA QL R E V AE+++SVTIYFSDIVGFT+LSAESTP+QV+ LLN LYT FD+I++N+DVYKVETIGDAY+VVSGLP RNG LH RE++RM+LA L A+ +F+I HR ++L +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMES G+A+KIH+S T VL+ F +F + RG+IE+KGKG TYWL GE
Sbjct: 99 LKLSHDPWAFIGPGCDYSSSPVARFTT-HWDVPMVTAGARADGFSK---FAAVTNTGPTHKKLGEFSLKIQETFGW----HHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFDYFVESNI-----NHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWF---RGDQDDHAARLAFR--------VRHPSIFNSFS--VYNLSTTITPQSFMQIKMC--------------------------SEPVWCVVSAGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVKHLPKG----------LNFQWPG--GSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSW-----------------VDIQMSNLDKVLRRACSRLTISMKG---------------------------------SNY--GSLMTMEG-------NLQIYTKTGYYKGNLVAIKYI-NKKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSS---CPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYI-DTHTLI-PKEIIQGVIRGGVPLLRPSLCFHS--HSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHR-GYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGE 991
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000039747.1 (SMESG000039747.1) HSP 1 Score: 2268.04 bits (5876), Expect = 0.000e+0 Identity = 1116/1120 (99.64%), Postives = 1120/1120 (100.00%), Query Frame = 2
Query: 77 MLLILSIVVFNYFINAENSKKHQMVIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASVIY 3436
MLLILSIVVFNYFINAENSKKHQMVIGIILENNSSQN+LGNLPTLDQIVPAVDIAFEKIK+KFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFALTLSTILLVILIIAAVVSIVIYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFL+ALFTFQIPHRQDR+LHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASVIY
Sbjct: 1 MLLILSIVVFNYFINAENSKKHQMVIGIILENNSSQNHLGNLPTLDQIVPAVDIAFEKIKKKFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFALTLSTILLVILIIAAVVSIVIYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLRALFTFQIPHRQDRQLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASVIY 1120
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000039747.1 (SMESG000039747.1) HSP 1 Score: 2224.13 bits (5762), Expect = 0.000e+0 Identity = 1093/1097 (99.64%), Postives = 1097/1097 (100.00%), Query Frame = 2
Query: 146 MVIGIILENNSSQNNLGNLPTLDQIVPAVDIAFEKIKQKFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASVIY 3436
MVIGIILENNSSQN+LGNLPTLDQIVPAVDIAFEKIK+KFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFALTLSTILLVILIIAAVVSIVIYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFL+ALFTFQIPHRQDR+LHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASVIY
Sbjct: 1 MVIGIILENNSSQNHLGNLPTLDQIVPAVDIAFEKIKKKFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLRKKQDFQMLTSTLFTFQDLKYVLLAMFDEFKWKPRSYKNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSKSLGSQDVSRFVVAFHDSVLIYAHALNDCLDKNVSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDCNFGFALTLSTILLVILIIAAVVSIVIYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENEFNMENHYLMTNKDVQLFQGGSFRNARRLSNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLRALFTFQIPHRQDRQLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEASVIY 1097
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000068881.1 (SMESG000068881.1) HSP 1 Score: 1007.67 bits (2604), Expect = 0.000e+0 Identity = 556/1106 (50.27%), Postives = 737/1106 (66.64%), Query Frame = 2
Query: 218 IVPAVDIAFEKIK----QKFIRFRNFELVTVTKTLTKSMSKSLWEIIDLLQNSTRPQVILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLR--KKQDFQMLT--STLFTFQDLKYVLLAMFDEFKWKPRSY----------KNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDIL-NKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKS-KSLGS-QDVSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDC---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENE-----FNMENHYLMTNKDVQLFQGGSFRNAR--RLS--NWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLE-PQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSL-VEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEA 3424
++ A DIA EKI+ FIR + + L M L+ + LL S +P V GP+ D+++A RL + +P++TP G + R K +++ LT +++ LK + +F + W ++VG +FD EN N +K++ N + EI ++ + +++LC +PE +R I+ A+ L F G+Y FI+ D+L +K+ +Q+PWYS ++ + N K+AYRSLL +T PES +++F +EVK ++ + GS ++ ++F+ FHDS+L+YA ALND + N++ +G IT +M N++I GI+G + ID NGDRNADYS+LDMD T F++VA G + + PV IDWVN N PP P CG++ +C G + IL+ A + IY+ KF EL AMNWLI WD +ET EKR L + SEL K F ++ F+ E+ L+ N + G +R R++ N S NS E+ G+Q +NL + F T +YK +VA+K + +KK+EIN++LLI+VKKVK+LNN+HICRFIG CL+ PQH +L+EYCPKGSLQD+LEN+QI LDW+FKFSL+QDICRGMIYLHSNIGPHGNLKSSNCL+DSRFV+K+ DFGL+KLRG+K++LLE + YA+YRNLLWTAPEILR + + ++ + K D+YSF II QE++YRNGVFYL + +EP++IVE V + + IP+RP+L E+E + II+Q W+E RP+ R IK M R NK GDSGNILDNLLSRMEQYANNLE LV QRTEQYLEEKRK EDLLY MLPKSVA QLIRNE VTAESYE V+IYFSDIVGFT+LSAESTPMQVIELLN LYTTFDSI+E++DVYKVETIGDAY+V SGLPQRNG++H REI+RMSLAFL A+F FQIPH+ ++R+ +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG +KIH+S ++DVL+TF FII++RGQ+ +KGKG+QTTYWLHGE IVDP+ PE+
Sbjct: 58 MLSAFDIALEKIRTWNIHPFIRKLKYYADADSDCLASRMP--LYYTVKLLMKS-KPGVWFGPICDYSLAPIARLLPF-WDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGT-LFDSENYKN-------KTFKSVVLLNAETLLEI-----------------DMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKR-------------HRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSL----AGDVVKSRPSRVNSINISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHW-LLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDIN--LEPKQIVEFVTKVQLIPYRPFLS-ENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPI-PES 1112
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000068881.1 (SMESG000068881.1) HSP 1 Score: 994.956 bits (2571), Expect = 0.000e+0 Identity = 539/1049 (51.38%), Postives = 712/1049 (67.87%), Query Frame = 2
Query: 377 VILGPLDDFNIANAVRLSDGRYRVPLLTPGGNALGLR--KKQDFQMLT--STLFTFQDLKYVLLAMFDEFKWKPRSY----------KNVGLYIFDMENDNNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDIL-NKSQSQRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKS-KSLGS-QDVSRFVVAFHDSVLIYAHALNDCLDKNVS--DGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDC---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAENE-----FNMENHYLMTNKDVQLFQGGSFRNAR--RLS--NWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLE-PQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSL-VEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPVLPEA 3424
V GP+ D+++A RL + +P++TP G + R K +++ LT +++ LK + +F + W ++VG +FD EN N +K++ N + EI ++ + +++LC +PE +R I+ A+ L F G+Y FI+ D+L +K+ +Q+PWYS ++ + N K+AYRSLL +T PES +++F +EVK ++ + GS ++ ++F+ FHDS+L+YA ALND + N++ +G IT +M N++I GI+G + ID NGDRNADYS+LDMD T F++VA G + + PV IDWVN N PP P CG++ +C G + IL+ A + IY+ KF EL AMNWLI WD +ET EKR L + SEL K F ++ F+ E+ L+ N + G +R R++ N S NS E+ G+Q +NL + F T +YK +VA+K + +KK+EIN++LLI+VKKVK+LNN+HICRFIG CL+ PQH +L+EYCPKGSLQD+LEN+QI LDW+FKFSL+QDICRGMIYLHSNIGPHGNLKSSNCL+DSRFV+K+ DFGL+KLRG+K++LLE + YA+YRNLLWTAPEILR + + ++ + K D+YSF II QE++YRNGVFYL + +EP++IVE V + + IP+RP+L E+E + II+Q W+E RP+ R IK M R NK GDSGNILDNLLSRMEQYANNLE LV QRTEQYLEEKRK EDLLY MLPKSVA QLIRNE VTAESYE V+IYFSDIVGFT+LSAESTPMQVIELLN LYTTFDSI+E++DVYKVETIGDAY+V SGLPQRNG++H REI+RMSLAFL A+F FQIPH+ ++R+ +RIG+HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG +KIH+S ++DVL+TF FII++RGQ+ +KGKG+QTTYWLHGE IVDP+ PE+
Sbjct: 53 VWFGPICDYSLAPIARLLPF-WDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLNFCRSVGT-LFDSENYKN-------KTFKSVVLLNAETLLEI-----------------DMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYGSVEESNKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKR-------------HRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSL----AGDVVKSRPSRVNSINISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHW-LLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLSDIN--LEPKQIVEFVTKVQLIPYRPFLS-ENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPI-PES 1053
BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000056411.1 (SMESG000056411.1) HSP 1 Score: 980.319 bits (2533), Expect = 0.000e+0 Identity = 524/1057 (49.57%), Postives = 705/1057 (66.70%), Query Frame = 2
Query: 371 PQVILGPLDDFNIANAVRLSDGRYRVPLLTPGG--NALGLRKKQDFQMLTSTLFTFQD--LKYVLLAMFDEFKWKPRSYKNVGLYIF--DMEND------NNLGDFISEVVYKTLQDANFKIAKEIYKQKLTARPPNHKDNLRELSKNSRIIILCAKPEVIRDIMKAAYDLGFHKGDYAFISFDILNKSQS-QRPWYSPLNSTQENEILKKAYRSLLIITLTLPESNNFKSFSEEVKQKSK-----SLGSQDVSRFVVAFHDSVLIYAHALNDCLDKN--VSDGDHITEQMKNKSINGISGNVHIDSNGDRNADYSLLDMDPKTETFQVVAIVNGSDKKFSPVANVQIDWVNVNNRPPLDTPKCGFSNTDC---NFGFAXXXXXXXXXXXXXXXXXXXXXYRHFKFHIELKAMNWLIMWDCIETTEKRKARYSDNKVKLKQENLNKLIYPECEESELMNKSFAEN----------EFNMENHYLMTNKDVQLFQGGSFRNARRL-------SNWSENSLETLAGIQFENLRNHQMFSKTGVYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDWIFKFSLIQDICRGMIYLHSNIGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILRNSNSLVEGTVKGDIYSFAIILQEIIYRNGVFYLGEFETP---IEPQEIVERVKQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKAGDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLKALFTFQIPHRQDRRLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGEDIVDPV 3412
P VI GP+ D+ IA RL + P++T G A + +F LT D Y++ +F ++KW N G YIF D N + LG ++ + K +++ K+ E++ + + ++ + I ILCA P+++R IM A L F G+Y F++ DI + +RPWY +ENEI KKA+R+L+ ITL PE +K FS EVK+++K + ++ V+ FV +FHD+V++YA LND L K + DG+ + + M N+S + V I +GDR AD+SL+D++ +T F+VV+ G +K+ PV + IDW VNN+ PLDTP CG+ + C + + ++ + IA + + I+R KF EL AMNW+I WD +ET+EKR+ ++SD +N + Y + S +MNK+ EN ++EN+YLMT+ D + RR SN S SL+T+ GI +++ Q+F+KT ++K +VA+KPI KIEI LLI++KK+KD++NDHICRFIG CL+ H I+ EYCPKGSL+DVL +QIKLDW+FK+SL+QDICRGMIYLH+N GPHGNLKSSNCL+DSRFV+K+TDFGL L+G+K +++ E P +Y++ LWTAPE+L SN V GT+KGD+YSFA+I QEI+YRNGVF L TP + +EI E+V+ PFRP L ++ ++ +I+Q W+E P RP+ IK++ RK NK GD+GNILDNLLSRMEQYANNLEGLV +RTEQYLEEK+KAEDLLY MLPK VA QLI+N+ V AESY+ VTI+FSDIVGFT+LSAESTPMQ+IELLN LYTTFDSI+ENYDVYKVETIGDAY+V SGLPQ NGNLH+REI+RMS+AFL+A+ F IPHR D++L +RIG+HSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG +KIHIS++T ++L TFG+FII+ERG I+LKGKG Q TYWLHGE +IVDP+
Sbjct: 118 PDVIFGPICDYVIAPIARLM-AFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKW------NKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDG------DNFHP--YTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSKKKKHKLNKLRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGKIEITTELLIEIKKIKDMSNDHICRFIGVCLD--HPYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSL----TPDPNLTSKEIFEKVRNKDSPPFRPTL-MLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPL 1152 The following BLAST results are available for this feature:
BLAST of Guanylate cyclase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Guanylate cyclase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Guanylate cyclase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Guanylate cyclase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Guanylate cyclase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017219 ID=SMED30017219|Name=Guanylate cyclase|organism=Schmidtea mediterranea sexual|type=transcript|length=3521bpback to top protein sequence of SMED30017219-orf-1 >SMED30017219-orf-1 ID=SMED30017219-orf-1|Name=SMED30017219-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1121bp MLLILSIVVFNYFINAENSKKHQMVIGIILENNSSQNNLGNLPTLDQIVPback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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