Mediator of RNA polymerase II transcription subunit 10

Overview


Name	Mediator of RNA polymerase II transcription subunit 10
Smed ID	SMED30017211
Length (bp)	776

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Mediator of RNA polymerase II transcription subunit 10 (SMED30017211) t-SNE clustered cells

Violin plots show distribution of expression levels for Mediator of RNA polymerase II transcription subunit 10 (SMED30017211) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mediator of RNA polymerase II transcription subunit 10 (SMED30017211) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30017211

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
neoblast	SMED30017211	SMESG000065706.1	dd_Smed_v4_5622_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
zeta neoblast	SMED30017211	SMESG000065706.1	dd_Smed_v4_5622_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Human
Match: MED10 (mediator complex subunit 10 [Source:HGNC Symbol;Acc:HGNC:28760])

HSP 1 Score: 142.51 bits (358), Expect = 2.129e-42
Identity = 67/132 (50.76%), Postives = 97/132 (73.48%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            +KFD+LEE L+ F+E++R+ G+IV DFQ        QK+  +VT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D++ +F+ LLI E+S++ P +MA YR ++GE   P
Sbjct:    3 EKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPP 134

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BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Celegans
Match: mdt-10 (Mediator of RNA polymerase II transcription subunit 10 [Source:UniProtKB/Swiss-Prot;Acc:P45966])

HSP 1 Score: 74.3294 bits (181), Expect = 4.174e-16
Identity = 45/126 (35.71%), Postives = 69/126 (54.76%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMR--ELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMK 452
            DK   LE+ L+ F E+ R  G +  +FQ         R   LV  LQ+LD +K  F +  VP ++   +D G NP LY++ C+EK L KN+ V G+++   +FR  L+ E SE +P  +  YR ++
Sbjct:   52 DKILQLEKKLEEFQENARFIGDLASNFQTKYQDALNGRIYTLVRGLQDLDRMKGTFSDKKVPLDLLPYLDDGKNPCLYSKHCMEKTLEKNKAVNGKIEIYKKFRAHLMKEFSEEMPDLVMYYRSIR 177

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BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Fly
Match: MED10 (gene:FBgn0036581 transcript:FBtr0301481)

HSP 1 Score: 113.235 bits (282), Expect = 2.345e-31
Identity = 61/129 (47.29%), Postives = 86/129 (66.67%), Query Frame = 3

Query:   87 FDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTK-IDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPL 464
             +NLE  L+ FIE+VR+  +IV DFQ  G     QK+  LVT LQE+D ++ Q  +V VP EVF   ID   NPQLYT++CVEKALAKNE+VKG+++ L +F+  L+ E+ +  P+EM  YR  + + +
Sbjct:    5 LENLETQLEMFIENVRQIRIIVSDFQPQGQNVLNQKINSLVTGLQEIDKLRSQVQDVYVPFEVFFDYIDQDKNPQLYTKDCVEKALAKNEEVKGKIEGLKKFKTNLLLELYKTFPNEMNNYRAYRKDSM 133

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Fly
Match: MED10 (gene:FBgn0036581 transcript:FBtr0333560)

HSP 1 Score: 113.235 bits (282), Expect = 2.345e-31
Identity = 61/129 (47.29%), Postives = 86/129 (66.67%), Query Frame = 3

Query:   87 FDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTK-IDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPL 464
             +NLE  L+ FIE+VR+  +IV DFQ  G     QK+  LVT LQE+D ++ Q  +V VP EVF   ID   NPQLYT++CVEKALAKNE+VKG+++ L +F+  L+ E+ +  P+EM  YR  + + +
Sbjct:    5 LENLETQLEMFIENVRQIRIIVSDFQPQGQNVLNQKINSLVTGLQEIDKLRSQVQDVYVPFEVFFDYIDQDKNPQLYTKDCVEKALAKNEEVKGKIEGLKKFKTNLLLELYKTFPNEMNNYRAYRKDSM 133

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Zebrafish
Match: med10 (mediator complex subunit 10 [Source:NCBI gene;Acc:550394])

HSP 1 Score: 139.813 bits (351), Expect = 1.818e-41
Identity = 65/128 (50.78%), Postives = 95/128 (74.22%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGE 458
            +KFDNLEE L+ F+E++R+ G+IV DFQ        QK+  ++T LQ+++  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D+L +F+ LLISE+ ++ P EMA Y+ + G+
Sbjct:    3 EKFDNLEEHLEKFVENIRQLGIIVSDFQPSSQTGLNQKLNFMITGLQDIEKCRQQLHDINVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTLTKFKSLLISELGKVFPEEMAKYKAIHGD 130

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Zebrafish
Match: med10 (mediator complex subunit 10 [Source:NCBI gene;Acc:550394])

HSP 1 Score: 113.62 bits (283), Expect = 1.108e-31
Identity = 54/102 (52.94%), Postives = 76/102 (74.51%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNR 380
            +KFDNLEE L+ F+E++R+ G+IV DFQ        QK+  ++T LQ+++  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D+L R
Sbjct:    3 EKFDNLEEHLEKFVENIRQLGIIVSDFQPSSQTGLNQKLNFMITGLQDIEKCRQQLHDINVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTLTR 104

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Xenopus
Match: tulp1 (TUB like protein 1 [Source:Xenbase;Acc:XB-GENE-5732938])

HSP 1 Score: 145.206 bits (365), Expect = 1.746e-43
Identity = 69/132 (52.27%), Postives = 97/132 (73.48%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            +KFDNLEE L+ F+E++R+ G+IV DFQ        QK+  LVT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D+L +F+ LLI E+S++ P +MA Y+ ++GE   P
Sbjct:    3 EKFDNLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFLVTGLQDIDKCRQQLHDITVPLEVFDYIDQGRNPQLYTKECLERALAKNEQVKGKIDTLKKFKSLLIQELSKVFPEDMAKYKAIRGEDHPP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Mouse
Match: Med10 (mediator complex subunit 10 [Source:MGI Symbol;Acc:MGI:106331])

HSP 1 Score: 143.28 bits (360), Expect = 7.718e-43
Identity = 67/132 (50.76%), Postives = 97/132 (73.48%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            +KFD+LEE L+ F+E++R+ G+IV DFQ        QK+  +VT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D++ +F+ LLI E+S++ P +MA YR ++GE   P
Sbjct:    3 EKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Mouse
Match: Med10 (mediator complex subunit 10 [Source:MGI Symbol;Acc:MGI:106331])

HSP 1 Score: 114.005 bits (284), Expect = 3.698e-31
Identity = 59/126 (46.83%), Postives = 83/126 (65.87%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSL----------NRFRHLLISEMSEIIP 422
            +KFD+LEE L+ F+E++R+ G+IV DFQ        QK+  +VT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D++           R R LL S  + + P
Sbjct:    3 EKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKVRQTGSDVCTRTRELLASLRTGLAP 128

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Mouse
Match: Med10 (mediator complex subunit 10 [Source:MGI Symbol;Acc:MGI:106331])

HSP 1 Score: 110.153 bits (274), Expect = 2.406e-30
Identity = 53/98 (54.08%), Postives = 73/98 (74.49%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLD 368
            +KFD+LEE L+ F+E++R+ G+IV DFQ        QK+  +VT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D
Sbjct:    3 EKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKID 100

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Mouse
Match: Med10 (mediator complex subunit 10 [Source:MGI Symbol;Acc:MGI:106331])

HSP 1 Score: 81.6481 bits (200), Expect = 1.056e-19
Identity = 40/81 (49.38%), Postives = 56/81 (69.14%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRE 317
            +KFD+LEE L+ F+E++R+ G+IV DFQ        QK+  +VT LQ++D  + Q H++ VP EVF  ID G NPQLYT+E
Sbjct:    3 EKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKE 83

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. UniProt/SwissProt
Match: sp|Q6DJ25|MED10_XENTR (Mediator of RNA polymerase II transcription subunit 10 OS=Xenopus tropicalis OX=8364 GN=med10 PE=2 SV=1)

HSP 1 Score: 145.206 bits (365), Expect = 9.251e-43
Identity = 69/132 (52.27%), Postives = 97/132 (73.48%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            +KFDNLEE L+ F+E++R+ G+IV DFQ        QK+  LVT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D+L +F+ LLI E+S++ P +MA Y+ ++GE   P
Sbjct:    3 EKFDNLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFLVTGLQDIDKCRQQLHDITVPLEVFDYIDQGRNPQLYTKECLERALAKNEQVKGKIDTLKKFKSLLIQELSKVFPEDMAKYKAIRGEDHPP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. UniProt/SwissProt
Match: sp|Q9CXU0|MED10_MOUSE (Mediator of RNA polymerase II transcription subunit 10 OS=Mus musculus OX=10090 GN=Med10 PE=1 SV=1)

HSP 1 Score: 143.28 bits (360), Expect = 5.399e-42
Identity = 67/132 (50.76%), Postives = 97/132 (73.48%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            +KFD+LEE L+ F+E++R+ G+IV DFQ        QK+  +VT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D++ +F+ LLI E+S++ P +MA YR ++GE   P
Sbjct:    3 EKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. UniProt/SwissProt
Match: sp|Q5R6P5|MED10_PONAB (Mediator of RNA polymerase II transcription subunit 10 OS=Pongo abelii OX=9601 GN=MED10 PE=2 SV=1)

HSP 1 Score: 142.51 bits (358), Expect = 1.022e-41
Identity = 67/132 (50.76%), Postives = 97/132 (73.48%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            +KFD+LEE L+ F+E++R+ G+IV DFQ        QK+  +VT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D++ +F+ LLI E+S++ P +MA YR ++GE   P
Sbjct:    3 EKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. UniProt/SwissProt
Match: sp|Q9BTT4|MED10_HUMAN (Mediator of RNA polymerase II transcription subunit 10 OS=Homo sapiens OX=9606 GN=MED10 PE=1 SV=1)

HSP 1 Score: 142.51 bits (358), Expect = 1.022e-41
Identity = 67/132 (50.76%), Postives = 97/132 (73.48%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            +KFD+LEE L+ F+E++R+ G+IV DFQ        QK+  +VT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D++ +F+ LLI E+S++ P +MA YR ++GE   P
Sbjct:    3 EKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. UniProt/SwissProt
Match: sp|Q3ZCF2|MED10_BOVIN (Mediator of RNA polymerase II transcription subunit 10 OS=Bos taurus OX=9913 GN=MED10 PE=2 SV=1)

HSP 1 Score: 142.51 bits (358), Expect = 1.022e-41
Identity = 67/132 (50.76%), Postives = 97/132 (73.48%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            +KFD+LEE L+ F+E++R+ G+IV DFQ        QK+  +VT LQ++D  + Q H++ VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D++ +F+ LLI E+S++ P +MA YR ++GE   P
Sbjct:    3 EKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPP 134

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BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. TrEMBL
Match: A0A448X885 (Mediator of RNA polymerase II transcription subunit 10 OS=Protopolystoma xenopodis OX=117903 GN=MED10 PE=3 SV=1)

HSP 1 Score: 168.318 bits (425), Expect = 1.308e-48
Identity = 74/140 (52.86%), Postives = 110/140 (78.57%), Query Frame = 3

Query:   69 LMDKDKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEP--LVPIPSN 482
            + D+++F+ LEE ++  I H REAG+IVCD+Q  + + +++ ELV +LQ+++ +++ FH+V VP EVFTKIDAG NPQLYTREC+E+ALA+NE V+G+L+SL RFR LL+SE+S   P+E+A YR ++G+P    PIPS+
Sbjct:    1 MGDRNRFELLEEAIESIINHAREAGIIVCDYQPSITFQRRINELVIRLQDVNKLQNDFHDVFVPIEVFTKIDAGQNPQLYTRECMERALARNEAVRGKLESLRRFRALLMSELSSYFPNEIAKYRSVRGDPDAFAPIPSS 140

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. TrEMBL
Match: Q86E49 (Mediator of RNA polymerase II transcription subunit 10 OS=Schistosoma japonicum OX=6182 GN=MED10 PE=2 SV=1)

HSP 1 Score: 159.073 bits (401), Expect = 2.277e-45
Identity = 72/138 (52.17%), Postives = 109/138 (78.99%), Query Frame = 3

Query:   69 LMDKDKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVPIPSN 482
            ++D+++F+ LEE ++  I+H REAG++VCD+Q  V++ +K+ +LV KLQ++D ++ +  +V VP E+F+KIDAG NPQLYTREC+E+ALAKNE V+G+LDSL RFR LL+SE+S   P+EMA YR ++G+P  P+  +
Sbjct:    1 MVDRNRFEILEENIESIIDHCREAGIVVCDYQPSVSFQKKINDLVYKLQDVDRMQVEMQDVHVPIELFSKIDAGQNPQLYTRECMEQALAKNEAVRGKLDSLRRFRVLLMSELSRQFPNEMAKYRAVRGDPEAPVTGS 138

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. TrEMBL
Match: A0A183TG02 (Mediator of RNA polymerase II transcription subunit 10 OS=Schistocephalus solidus OX=70667 GN=MED10 PE=3 SV=1)

HSP 1 Score: 159.073 bits (401), Expect = 2.754e-45
Identity = 74/149 (49.66%), Postives = 110/149 (73.83%), Query Frame = 3

Query:   69 LMDKDKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP-IPSNPNMESQTVDN 512
            + D+ KF+ LEE ++  I H REAG+IVCD+Q  V + +K+ +LV KLQ++D ++    +V VP EVF+KIDAG NPQ+YTREC+E+A+A+NE V+G+L+SL RFR LL++E+S+  P+EMA YR ++G+P  P  PS+ N   + + N
Sbjct:    1 MADRGKFEQLEEYIESTINHCREAGIIVCDYQPGVAFHKKINDLVYKLQDVDRMQQDMQDVYVPIEVFSKIDAGENPQIYTRECMERAIARNEAVRGKLESLRRFRALLMAELSKKFPNEMAKYRSVRGDPEAPTFPSSANNSVENMQN 149

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. TrEMBL
Match: A0A095A0D9 (Mediator of RNA polymerase II transcription subunit 10 OS=Schistosoma haematobium OX=6185 GN=MED10 PE=3 SV=1)

HSP 1 Score: 158.303 bits (399), Expect = 4.758e-45
Identity = 72/134 (53.73%), Postives = 107/134 (79.85%), Query Frame = 3

Query:   69 LMDKDKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            ++D+++F+ LEE ++  I+H REAG++VCD+Q  V++ +K+ +LV KLQ++D ++ +  +V VP E+F+KIDAG NPQLYTREC+E+ALAKNE V+G+LDSL RFR LL+SE+S   P+EMA YR ++G+P  P
Sbjct:    1 MVDRNRFEILEENIESIIDHCREAGIVVCDYQPSVSFQKKINDLVYKLQDVDRMQVEMQDVHVPIELFSKIDAGQNPQLYTRECMEQALAKNEAVRGKLDSLRRFRMLLMSELSRQFPNEMAKYRAVRGDPEAP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. TrEMBL
Match: A0A183NX68 (Mediator of RNA polymerase II transcription subunit 10 OS=Schistosoma mattheei OX=31246 GN=MED10 PE=3 SV=1)

HSP 1 Score: 158.303 bits (399), Expect = 4.758e-45
Identity = 72/134 (53.73%), Postives = 107/134 (79.85%), Query Frame = 3

Query:   69 LMDKDKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            ++D+++F+ LEE ++  I+H REAG++VCD+Q  V++ +K+ +LV KLQ++D ++ +  +V VP E+F+KIDAG NPQLYTREC+E+ALAKNE V+G+LDSL RFR LL+SE+S   P+EMA YR ++G+P  P
Sbjct:    1 MVDRNRFEILEENIESIIDHCREAGIVVCDYQPSVSFQKKINDLVYKLQDVDRMQVEMQDVHVPIELFSKIDAGQNPQLYTRECMEQALAKNEAVRGKLDSLRRFRMLLMSELSRQFPNEMAKYRAVRGDPEAP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Cavefish
Match: med10 (mediator complex subunit 10 [Source:NCBI gene;Acc:103037742])

HSP 1 Score: 134.035 bits (336), Expect = 2.243e-39
Identity = 62/128 (48.44%), Postives = 94/128 (73.44%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGE 458
            +KFDNLEE L+ FIE++R+ G+IV DFQ        QK+  ++T LQ+++  + Q +++ VP E F  ID G NPQLYT+EC+E+ALAKNEQVKG++D++ +F+ LLI+E+ ++ P EMA Y+ + G+
Sbjct:    3 EKFDNLEEHLEKFIENIRQMGIIVSDFQPSSQTGLNQKLNFMITGLQDVEKCRQQLNDIHVPLEAFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMTKFKSLLITELGKVFPEEMAKYKAIHGD 130

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Cavefish
Match: med10 (mediator complex subunit 10 [Source:NCBI gene;Acc:103037742])

HSP 1 Score: 56.6102 bits (135), Expect = 5.605e-10
Identity = 28/66 (42.42%), Postives = 44/66 (66.67%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVF 272
            +KFDNLEE L+ FIE++R+ G+IV DFQ        QK+  ++T LQ+++  + Q +++ VP E F
Sbjct:    3 EKFDNLEEHLEKFIENIRQMGIIVSDFQPSSQTGLNQKLNFMITGLQDVEKCRQQLNDIHVPLEAF 68

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010861.1 (pep scaffold:Pmarinus_7.0:GL479378:1195:19279:1 gene:ENSPMAG00000009841.1 transcript:ENSPMAT00000010861.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 112.849 bits (281), Expect = 9.616e-32
Identity = 55/102 (53.92%), Postives = 76/102 (74.51%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNR 380
            +KFDNLEE L+ FIE++R+ G+IV DFQ  G V   QK+  ++  LQE++  +   H+V VP EVF  ID G NPQLYT+EC+E+ALAKNEQVKG++D++ +
Sbjct:    3 EKFDNLEEHLEKFIENIRQLGIIVSDFQPSGQVVLNQKLNTMIGGLQEIEKCRQSLHDVHVPLEVFEYIDQGKNPQLYTKECLERALAKNEQVKGKIDAMKK 104

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Yeast
Match: NUT2 (Subunit of the RNA polymerase II mediator complex; conserved from yeast to human; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000006372])

HSP 1 Score: 46.595 bits (109), Expect = 5.304e-7
Identity = 33/114 (28.95%), Postives = 52/114 (45.61%), Query Frame = 3

Query:  114 GFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQE-LDSI----------KDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIP 422
              IE   E GV + DF G    P+  + ++T LQ  +D +          +     V +P EV   I+ G NP +YTRE VE     N+  +G++  L + R  L  ++ +  P
Sbjct:   24 SIIESFVELGVSIYDFPGT---PEATKGMITNLQRNVDRLYKLNVRSNDPQSSLSKVDIPLEVVQYIEDGRNPDIYTREFVEAIRRSNQYQRGKMHGLKQLRDSLADKIVDEFP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Nematostella
Match: EDO47250 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMD0])

HSP 1 Score: 114.775 bits (286), Expect = 3.600e-32
Identity = 59/126 (46.83%), Postives = 86/126 (68.25%), Query Frame = 3

Query:   87 FDNLEELLDGFIEHVREAGVIVCDFQ----GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMK 452
            FD LE+ ++ F+E  R+ G+IV DFQ    G +N  QK+  +V  L+E++  K    +V VP EVF  ID G NPQLYT++C+EKAL KNEQVKG++D+   F+ LL+ E+S+++P +M  Y K+K
Sbjct:   11 FDLLEQTIEQFVETTRQIGIIVSDFQPGSQGVLN--QKINMMVDNLREIEKCKAHVADVEVPLEVFEYIDQGRNPQLYTKDCLEKALVKNEQVKGKIDAYKNFKSLLVDELSKVLPKDMKEYNKIK 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Nematostella
Match: EDO29867 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2E5])

HSP 1 Score: 113.235 bits (282), Expect = 1.133e-31
Identity = 59/126 (46.83%), Postives = 85/126 (67.46%), Query Frame = 3

Query:   87 FDNLEELLDGFIEHVREAGVIVCDFQ----GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMK 452
            FD LE+ ++ F+E  R+ G+IV DFQ    G +N  QK+  +V  L+E++  K    +V VP EVF  ID G NPQLYT++C+EKAL KNEQVKG++D+   F+ LL+ E+S+++P  M  Y K+K
Sbjct:   11 FDLLEQTIEQFVETTRQIGIIVSDFQPGSQGVLN--QKINMMVDNLREIEKCKAHVADVEVPLEVFEYIDQGRNPQLYTKDCLEKALVKNEQVKGKIDAYKNFKSLLVDELSKVLPKGMKEYNKIK 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Medaka
Match: MED10 (mediator complex subunit 10 [Source:NCBI gene;Acc:101156263])

HSP 1 Score: 137.502 bits (345), Expect = 9.724e-41
Identity = 65/132 (49.24%), Postives = 96/132 (72.73%), Query Frame = 3

Query:   81 DKFDNLEELLDGFIEHVREAGVIVCDFQ--GHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVP 470
            +KFDNLEE L+ F+E++R+ G+IV DFQ        QK+  +++ LQ+++  + Q H + VP EVF  ID G NPQLYT+EC+E+ALA+NEQVKG++D++ +F+ LLISE+S++ P EMA Y+ + GE   P
Sbjct:    3 EKFDNLEEHLEKFVENIRQLGIIVSDFQPSSQAVLNQKLNFMISGLQDIEKCRQQLHEINVPLEVFDYIDQGRNPQLYTKECLERALARNEQVKGKIDTMMKFKSLLISELSKVFPEEMAKYKAIHGEDAPP 134

[Close]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Planmine SMEST
Match: SMESG000065706.1 (SMESG000065706.1)

HSP 1 Score: 318.931 bits (816), Expect = 5.445e-112
Identity = 154/154 (100.00%), Postives = 154/154 (100.00%), Query Frame = 3

Query:   72 MDKDKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVPIPSNPNMESQTVDNQIIHDQK 533
            MDKDKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVPIPSNPNMESQTVDNQIIHDQK
Sbjct:    1 MDKDKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQELDSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDSLNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVPIPSNPNMESQTVDNQIIHDQK 154

The following BLAST results are available for this feature:

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Human
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Celegans
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Fly
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Zebrafish
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Xenopus
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Mouse
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. UniProt/SwissProt
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. TrEMBL
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Cavefish
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Sea Lamprey
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Yeast
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Nematostella
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Medaka
BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Planmine SMEST

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
MED10	2.129e-42	50.76	mediator complex subunit 10 [Source:HGNC Symbol;Ac...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
mdt-10	4.174e-16	35.71	Mediator of RNA polymerase II transcription subuni...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
MED10	2.345e-31	47.29	gene:FBgn0036581 transcript:FBtr0301481	[more]
MED10	2.345e-31	47.29	gene:FBgn0036581 transcript:FBtr0333560	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
med10	1.818e-41	50.78	mediator complex subunit 10 [Source:NCBI gene;Acc:...	[more]
med10	1.108e-31	52.94	mediator complex subunit 10 [Source:NCBI gene;Acc:...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
tulp1	1.746e-43	52.27	TUB like protein 1 [Source:Xenbase;Acc:XB-GENE-573...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Med10	7.718e-43	50.76	mediator complex subunit 10 [Source:MGI Symbol;Acc...	[more]
Med10	3.698e-31	46.83	mediator complex subunit 10 [Source:MGI Symbol;Acc...	[more]
Med10	2.406e-30	54.08	mediator complex subunit 10 [Source:MGI Symbol;Acc...	[more]
Med10	1.056e-19	49.38	mediator complex subunit 10 [Source:MGI Symbol;Acc...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6DJ25\|MED10_XENTR	9.251e-43	52.27	Mediator of RNA polymerase II transcription subuni...	[more]
sp\|Q9CXU0\|MED10_MOUSE	5.399e-42	50.76	Mediator of RNA polymerase II transcription subuni...	[more]
sp\|Q5R6P5\|MED10_PONAB	1.022e-41	50.76	Mediator of RNA polymerase II transcription subuni...	[more]
sp\|Q9BTT4\|MED10_HUMAN	1.022e-41	50.76	Mediator of RNA polymerase II transcription subuni...	[more]
sp\|Q3ZCF2\|MED10_BOVIN	1.022e-41	50.76	Mediator of RNA polymerase II transcription subuni...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A448X885	1.308e-48	52.86	Mediator of RNA polymerase II transcription subuni...	[more]
Q86E49	2.277e-45	52.17	Mediator of RNA polymerase II transcription subuni...	[more]
A0A183TG02	2.754e-45	49.66	Mediator of RNA polymerase II transcription subuni...	[more]
A0A095A0D9	4.758e-45	53.73	Mediator of RNA polymerase II transcription subuni...	[more]
A0A183NX68	4.758e-45	53.73	Mediator of RNA polymerase II transcription subuni...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
med10	2.243e-39	48.44	mediator complex subunit 10 [Source:NCBI gene;Acc:...	[more]
med10	5.605e-10	42.42	mediator complex subunit 10 [Source:NCBI gene;Acc:...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000010861.1	9.616e-32	53.92	pep scaffold:Pmarinus_7.0:GL479378:1195:19279:1 ge...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
NUT2	5.304e-7	28.95	Subunit of the RNA polymerase II mediator complex;...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO47250	3.600e-32	46.83	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO29867	1.133e-31	46.83	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
MED10	9.724e-41	49.24	mediator complex subunit 10 [Source:NCBI gene;Acc:...	[more]

BLAST of Mediator of RNA polymerase II transcription subunit 10 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000065706.1	5.445e-112	100.00	SMESG000065706.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30017211 ID=SMED30017211|Name=Mediator of RNA polymerase II transcription subunit 10|organism=Schmidtea mediterranea sexual|type=transcript|length=776bp
TAATAATATTTGCATTTTGAATTTGTGATTTAAAAAGATTAATTTACTTT
TTAACTAATTAGTATATTCTTATGGATAAAGATAAATTTGATAACCTGGA
AGAATTATTAGATGGGTTTATTGAACATGTACGAGAAGCTGGAGTTATTG
TATGTGATTTTCAGGGTCATGTAAATTATCCTCAAAAAATGAGAGAGCTT
GTTACAAAATTACAAGAGCTTGACAGTATTAAAGATCAATTTCACAATGT
CATTGTCCCAGAAGAAGTTTTCACCAAAATAGATGCTGGTTGTAATCCTC
AGTTATACACTAGAGAATGTGTTGAAAAAGCCTTAGCGAAAAATGAGCAA
GTAAAAGGTCAATTGGATAGCCTAAACCGATTTAGGCATTTACTTATTAG
CGAAATGTCTGAAATTATACCTCATGAAATGGCCATGTATAGGAAAATGA
AAGGTGAACCACTCGTACCAATCCCATCAAATCCCAACATGGAATCACAA
ACAGTCGATAATCAAATAATTCATGATCAAAAATAATATTCAATATGAAT
TTTATTATGATTAAATCTATTTTGATGATTTACATTTTTTCTTAAACATT
TCATAGGTTTTGTTTTTTATTTTTCGTGCCGGCATCTTTGGATGCTTCAC
TCTCAACTTTTGATATTCTCGTGATGTATAAGTGATGAAATCATTTTTCC
CAGATTTAATTTTCCTTGGCTTTCCGTATTTTAATTTGTCTTTTAGATTC
ATATTTCTCCACATATTAGAAAGTTT

protein sequence of SMED30017211-orf-1

>SMED30017211-orf-1 ID=SMED30017211-orf-1|Name=SMED30017211-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=155bp
MDKDKFDNLEELLDGFIEHVREAGVIVCDFQGHVNYPQKMRELVTKLQEL
DSIKDQFHNVIVPEEVFTKIDAGCNPQLYTRECVEKALAKNEQVKGQLDS
LNRFRHLLISEMSEIIPHEMAMYRKMKGEPLVPIPSNPNMESQTVDNQII
HDQK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0003712	transcription cofactor activity
GO:0001104	RNA polymerase II transcription cofactor activity

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0016592	mediator complex

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000014	zeta neoblast
PLANA:0000429	neoblast

Vocabulary: **INTERPRO**
Term	Definition
IPR019145	Mediator_Med10
IPR029063	SAM-dependent_MTases

Vocabulary: **biological process**
Term	Definition
GO:0006357	regulation of transcription from RNA polymerase II promoter

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR019145	Mediator complex, subunit Med10	PFAM	PF09748	Med10	coord: 11..124 e-value: 3.4E-27 score: 94.8
None	No IPR available	PANTHER	PTHR13345	NUT2 AND UXT	coord: 3..130
None	No IPR available	PANTHER	PTHR13345:SF2	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10	coord: 3..130