DIX domain containing 1

Overview


Name	DIX domain containing 1
Smed ID	SMED30017209
Length (bp)	2178

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of DIX domain containing 1 (SMED30017209) t-SNE clustered cells

Violin plots show distribution of expression levels for DIX domain containing 1 (SMED30017209) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DIX domain containing 1 (SMED30017209) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DIX domain containing 1 (SMED30017209) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30017209

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30017209	SMESG000033276.1 SMESG000003898.1	dd_Smed_v4_3834_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30017209	SMESG000033276.1 SMESG000003898.1	dd_Smed_v4_3834_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parapharyngeal region	SMED30017209	SMESG000033276.1 SMESG000003898.1	dd_Smed_v4_3834_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30017209	SMESG000033276.1 SMESG000003898.1	dd_Smed_v4_3834_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30017209	SMESG000033276.1 SMESG000003898.1	dd_Smed_v4_3834_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30017209	SMESG000033276.1 SMESG000003898.1	dd_Smed_v4_3834_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of DIX domain containing 1 vs. Ensembl Human
Match: DIXDC1 (DIX domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23695])

HSP 1 Score: 68.1662 bits (165), Expect = 2.618e-11
Identity = 44/161 (27.33%), Postives = 84/161 (52.17%), Query Frame = 2

Query: 1544 LDKFDEGIN-LMTLISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSENFDQQEKLNNPFISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            +D  ++GI+ LM  + +    + ++  V + +P    ++V S++          E++    KL +   S T S    T TK++YF  +S  P++  IP+ L  +TL D K    + + ++ N RY FK    + G+ K+EI  D D++P  +GKI+ ++++
Sbjct:  326 IDSLEQGISSLMERLHVMETQKKQERKVRVKSP---RTQVGSEY---------RESWPPNSKLPHSQSSPTVS---STCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFK----AAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEE 467

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Human
Match: DIXDC1 (DIX domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23695])

HSP 1 Score: 68.1662 bits (165), Expect = 4.091e-11
Identity = 44/161 (27.33%), Postives = 84/161 (52.17%), Query Frame = 2

Query: 1544 LDKFDEGIN-LMTLISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSENFDQQEKLNNPFISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            +D  ++GI+ LM  + +    + ++  V + +P    ++V S++          E++    KL +   S T S    T TK++YF  +S  P++  IP+ L  +TL D K    + + ++ N RY FK    + G+ K+EI  D D++P  +GKI+ ++++
Sbjct:  537 IDSLEQGISSLMERLHVMETQKKQERKVRVKSP---RTQVGSEY---------RESWPPNSKLPHSQSSPTVS---STCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFK----AAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEE 678

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Human
Match: DVL2 (dishevelled segment polarity protein 2 [Source:HGNC Symbol;Acc:HGNC:3086])

HSP 1 Score: 58.9214 bits (141), Expect = 1.458e-8
Identity = 30/81 (37.04%), Postives = 46/81 (56.79%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  IP P   ITL D K    SVL +    +YFFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFK----SVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWL 89

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Human
Match: DVL2 (dishevelled segment polarity protein 2 [Source:HGNC Symbol;Acc:HGNC:3086])

HSP 1 Score: 57.7658 bits (138), Expect = 7.106e-8
Identity = 30/81 (37.04%), Postives = 46/81 (56.79%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  IP P   ITL D K    SVL +    +YFFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFK----SVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWL 89

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Human
Match: DVL2 (dishevelled segment polarity protein 2 [Source:HGNC Symbol;Acc:HGNC:3086])

HSP 1 Score: 57.7658 bits (138), Expect = 7.255e-8
Identity = 30/81 (37.04%), Postives = 46/81 (56.79%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  IP P   ITL D K    SVL +    +YFFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFK----SVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWL 89

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Fly
Match: dsh (gene:FBgn0000499 transcript:FBtr0073454)

HSP 1 Score: 57.3806 bits (137), Expect = 3.311e-8
Identity = 28/85 (32.94%), Postives = 48/85 (56.47%), Query Frame = 2

Query: 1763 GNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            G   +TK+IY +     PY+  IP P + +TL D K   N    ++ N++YFFK+  +D G  K+EI  D   +P  +G+++ ++
Sbjct:    6 GGGQETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNK---QNNNYKYFFKSMDADFGVVKEEIADDSTILPCFNGRVVSWL 87

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BLAST of DIX domain containing 1 vs. Ensembl Zebrafish
Match: dixdc1b (DIX domain containing 1b [Source:ZFIN;Acc:ZDB-GENE-041008-148])

HSP 1 Score: 63.929 bits (154), Expect = 4.075e-10
Identity = 27/82 (32.93%), Postives = 50/82 (60.98%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++YF  +S  P++  IP+ L  +TL D K    + + ++ N+RY FK    + G+ K+E+ +D   VP  +GKI+ ++++
Sbjct:  520 TKVLYFTDRSLTPFMINIPKRLGEVTLQDFK----TAVDREGNYRYHFKALDPEFGTVKEEVFQDDAVVPGWEGKIVAWVEE 597

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Zebrafish
Match: dixdc1b (DIX domain containing 1b [Source:ZFIN;Acc:ZDB-GENE-041008-148])

HSP 1 Score: 63.5438 bits (153), Expect = 6.071e-10
Identity = 27/82 (32.93%), Postives = 50/82 (60.98%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++YF  +S  P++  IP+ L  +TL D K    + + ++ N+RY FK    + G+ K+E+ +D   VP  +GKI+ ++++
Sbjct:  593 TKVLYFTDRSLTPFMINIPKRLGEVTLQDFK----TAVDREGNYRYHFKALDPEFGTVKEEVFQDDAVVPGWEGKIVAWVEE 670

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BLAST of DIX domain containing 1 vs. Ensembl Zebrafish
Match: dixdc1a (DIX domain containing 1a [Source:NCBI gene;Acc:360137])

HSP 1 Score: 60.4622 bits (145), Expect = 3.795e-9
Identity = 25/82 (30.49%), Postives = 50/82 (60.98%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++Y+  +S  P++  IP+ L  +TL D K    + + +  +FRY FK+   + G+ K+E+ +D   +P  +GKI+ ++++
Sbjct:  360 TKVLYYTDRSLTPFLVNIPKRLGDVTLQDFK----AAVDRHGSFRYHFKSLDPEFGTVKEEVFQDDAVIPGWEGKIVAWVEE 437

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Zebrafish
Match: dvl3b (dishevelled segment polarity protein 3b [Source:ZFIN;Acc:ZDB-GENE-121101-2])

HSP 1 Score: 54.299 bits (129), Expect = 4.284e-7
Identity = 29/82 (35.37%), Postives = 50/82 (60.98%), Query Frame = 2

Query: 1772 TDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
             +TK+IY L +   PY+  +P P   +TLAD K    +VL+K  N+++FFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:    2 AETKIIYHLDEQETPYLIKLPIPAENVTLADFK----NVLNK-PNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWL 78

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Zebrafish
Match: dvl3a (dishevelled segment polarity protein 3a [Source:ZFIN;Acc:ZDB-GENE-010319-1])

HSP 1 Score: 53.9138 bits (128), Expect = 6.681e-7
Identity = 28/81 (34.57%), Postives = 48/81 (59.26%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L     PY+  +P P   +TL D+K   N++  K  N+++FFK+   D G  K+EI  D+  +P  +G++I ++
Sbjct:    3 ETKVIYHLDDQETPYLVKLPIPAERVTLLDLK---NAL--KKPNYKFFFKSMDDDFGVVKEEITDDNAKLPCYNGRVICWL 78

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BLAST of DIX domain containing 1 vs. Ensembl Xenopus
Match: ENSXETT00000001825.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV461245.1:5708:13762:1 gene:ENSXETG00000006251.1 transcript:ENSXETT00000001825.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.929 bits (154), Expect = 5.110e-11
Identity = 29/97 (29.90%), Postives = 54/97 (55.67%), Query Frame = 2

Query: 1736 PFISDTKSFGNK-TDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            P    T   GN  + TK++YF  +S  P++  IP+ L  +TL D +    + + ++ + RY FK    + G+ K+E+  D D +P  +GKI+ ++++
Sbjct:   95 PHSQSTPVMGNSNSSTKVLYFTDRSLTPFMVTIPKRLGEVTLRDFR----AAIGREGSHRYHFKALDPEFGTVKEEVFHDDDIIPGWEGKIVAWVEE 187

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Xenopus
Match: dvl3 (dishevelled segment polarity protein 3 [Source:NCBI gene;Acc:100144702])

HSP 1 Score: 55.0694 bits (131), Expect = 3.497e-7
Identity = 28/81 (34.57%), Postives = 49/81 (60.49%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  +P P   +TL D K    +VL+K  N+++FFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:    3 ETKVIYHLDEQETPYLVKLPVPAEKVTLGDFK----NVLNK-PNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVCWL 78

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Xenopus
Match: dvl3 (dishevelled segment polarity protein 3 [Source:NCBI gene;Acc:100144702])

HSP 1 Score: 55.0694 bits (131), Expect = 3.918e-7
Identity = 28/81 (34.57%), Postives = 49/81 (60.49%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  +P P   +TL D K    +VL+K  N+++FFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:    3 ETKVIYHLDEQETPYLVKLPVPAEKVTLGDFK----NVLNK-PNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVCWL 78

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Xenopus
Match: dvl3 (dishevelled segment polarity protein 3 [Source:NCBI gene;Acc:100144702])

HSP 1 Score: 55.0694 bits (131), Expect = 3.942e-7
Identity = 28/81 (34.57%), Postives = 49/81 (60.49%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  +P P   +TL D K    +VL+K  N+++FFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:    3 ETKVIYHLDEQETPYLVKLPVPAEKVTLGDFK----NVLNK-PNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVCWL 78

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Xenopus
Match: dvl3 (dishevelled segment polarity protein 3 [Source:NCBI gene;Acc:100144702])

HSP 1 Score: 55.0694 bits (131), Expect = 3.993e-7
Identity = 28/81 (34.57%), Postives = 49/81 (60.49%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  +P P   +TL D K    +VL+K  N+++FFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:    3 ETKVIYHLDEQETPYLVKLPVPAEKVTLGDFK----NVLNK-PNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVCWL 78

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Mouse
Match: Dixdc1 (DIX domain containing 1 [Source:MGI Symbol;Acc:MGI:2679721])

HSP 1 Score: 67.0106 bits (162), Expect = 6.714e-11
Identity = 28/84 (33.33%), Postives = 51/84 (60.71%), Query Frame = 2

Query: 1772 TDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            T TK++YF  +S  P++  IP+ L  +TL D K    + + ++ N RY FK    + G+ K+E+  D D++P  +GKI+ ++++
Sbjct:  601 TCTKVLYFTDRSLTPFMVNIPKRLGEVTLKDFK----AAIDREGNHRYHFKALDPEFGTVKEEVFHDDDAIPGWEGKIVAWVEE 680

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Mouse
Match: Dixdc1 (DIX domain containing 1 [Source:MGI Symbol;Acc:MGI:2679721])

HSP 1 Score: 66.6254 bits (161), Expect = 7.423e-11
Identity = 28/84 (33.33%), Postives = 51/84 (60.71%), Query Frame = 2

Query: 1772 TDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            T TK++YF  +S  P++  IP+ L  +TL D K    + + ++ N RY FK    + G+ K+E+  D D++P  +GKI+ ++++
Sbjct:  627 TCTKVLYFTDRSLTPFMVNIPKRLGEVTLKDFK----AAIDREGNHRYHFKALDPEFGTVKEEVFHDDDAIPGWEGKIVAWVEE 706

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Mouse
Match: Dixdc1 (DIX domain containing 1 [Source:MGI Symbol;Acc:MGI:2679721])

HSP 1 Score: 66.6254 bits (161), Expect = 8.659e-11
Identity = 28/84 (33.33%), Postives = 51/84 (60.71%), Query Frame = 2

Query: 1772 TDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            T TK++YF  +S  P++  IP+ L  +TL D K    + + ++ N RY FK    + G+ K+E+  D D++P  +GKI+ ++++
Sbjct:  626 TCTKVLYFTDRSLTPFMVNIPKRLGEVTLKDFK----AAIDREGNHRYHFKALDPEFGTVKEEVFHDDDAIPGWEGKIVAWVEE 705

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Mouse
Match: Dvl2 (dishevelled segment polarity protein 2 [Source:MGI Symbol;Acc:MGI:106613])

HSP 1 Score: 57.7658 bits (138), Expect = 4.417e-8
Identity = 30/81 (37.04%), Postives = 46/81 (56.79%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  IP P   ITL D K    SVL +    +YFFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFK----SVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWL 89

[Close]

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  IP P   ITL D K    SVL +    +YFFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFK----SVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWL 89

[Close]

BLAST of DIX domain containing 1 vs. UniProt/SwissProt
Match: sp|Q155Q3|DIXC1_HUMAN (Dixin OS=Homo sapiens OX=9606 GN=DIXDC1 PE=1 SV=2)

HSP 1 Score: 68.1662 bits (165), Expect = 1.965e-10
Identity = 44/161 (27.33%), Postives = 84/161 (52.17%), Query Frame = 2

Query: 1544 LDKFDEGIN-LMTLISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSENFDQQEKLNNPFISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            +D  ++GI+ LM  + +    + ++  V + +P    ++V S++          E++    KL +   S T S    T TK++YF  +S  P++  IP+ L  +TL D K    + + ++ N RY FK    + G+ K+EI  D D++P  +GKI+ ++++
Sbjct:  537 IDSLEQGISSLMERLHVMETQKKQERKVRVKSP---RTQVGSEY---------RESWPPNSKLPHSQSSPTVS---STCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFK----AAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEE 678

[Close]

BLAST of DIX domain containing 1 vs. UniProt/SwissProt
Match: sp|Q80Y83|DIXC1_MOUSE (Dixin OS=Mus musculus OX=10090 GN=Dixdc1 PE=1 SV=1)

HSP 1 Score: 66.6254 bits (161), Expect = 5.193e-10
Identity = 28/84 (33.33%), Postives = 51/84 (60.71%), Query Frame = 2

Query: 1772 TDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            T TK++YF  +S  P++  IP+ L  +TL D K    + + ++ N RY FK    + G+ K+E+  D D++P  +GKI+ ++++
Sbjct:  627 TCTKVLYFTDRSLTPFMVNIPKRLGEVTLKDFK----AAIDREGNHRYHFKALDPEFGTVKEEVFHDDDAIPGWEGKIVAWVEE 706

[Close]

BLAST of DIX domain containing 1 vs. UniProt/SwissProt
Match: sp|Q2VUH7|DIXC1_RAT (Dixin OS=Rattus norvegicus OX=10116 GN=Dixdc1 PE=2 SV=1)

HSP 1 Score: 62.3882 bits (150), Expect = 1.151e-8
Identity = 27/81 (33.33%), Postives = 48/81 (59.26%), Query Frame = 2

Query: 1772 TDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVF 2014
            T TK++YF  +S  P++  IP+ L  +TL D K    + + ++ + RY FK    + G+ K+E+  D D++P  +GKI+ +
Sbjct:  574 TCTKVLYFTDRSLTPFMVNIPKRLGEVTLKDFK----AAIDREGSHRYHFKALDPEFGTVKEEVFHDDDAIPGWEGKIVAW 650

[Close]

BLAST of DIX domain containing 1 vs. UniProt/SwissProt
Match: sp|Q804T6|DIX1A_DANRE (Dixin-A OS=Danio rerio OX=7955 GN=dixdc1a PE=1 SV=1)

HSP 1 Score: 60.4622 bits (145), Expect = 2.915e-8
Identity = 25/82 (30.49%), Postives = 50/82 (60.98%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++Y+  +S  P++  IP+ L  +TL D K    + + +  +FRY FK+   + G+ K+E+ +D   +P  +GKI+ ++++
Sbjct:  360 TKVLYYTDRSLTPFLVNIPKRLGDVTLQDFK----AAVDRHGSFRYHFKSLDPEFGTVKEEVFQDDAVIPGWEGKIVAWVEE 437

[Close]

BLAST of DIX domain containing 1 vs. UniProt/SwissProt
Match: sp|Q60838|DVL2_MOUSE (Segment polarity protein dishevelled homolog DVL-2 OS=Mus musculus OX=10090 GN=Dvl2 PE=1 SV=2)

HSP 1 Score: 57.7658 bits (138), Expect = 3.090e-7
Identity = 30/81 (37.04%), Postives = 46/81 (56.79%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +TK+IY L +   PY+  IP P   ITL D K    SVL +    +YFFK+   D G  K+EI  D+  +P  +G+++ ++
Sbjct:   13 ETKVIYHLDEEETPYLVKIPVPAERITLGDFK----SVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWL 89

[Close]

BLAST of DIX domain containing 1 vs. TrEMBL
Match: A0A3B5MUH5 (DIX domain containing 1 OS=Xiphophorus couchianus OX=32473 GN=DIXDC1 PE=4 SV=1)

HSP 1 Score: 74.3294 bits (181), Expect = 1.934e-11
Identity = 33/87 (37.93%), Postives = 54/87 (62.07%), Query Frame = 2

Query: 1763 GNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            G+ + TK++YF GKSP P +  IP+ L  +TL DVKE     + ++ N+RY FK    + G+ K+E+  D   VP  +GKI+ ++++
Sbjct:   98 GSPSSTKILYFTGKSPTPSMINIPKRLGEVTLKDVKE----AVDREGNYRYHFKALDPEFGTVKEEVFLDGAIVPGWEGKIVAWLEE 180

[Close]

BLAST of DIX domain containing 1 vs. TrEMBL
Match: A0A0S7FKW8 (DIX1A (Fragment) OS=Poeciliopsis prolifica OX=188132 GN=DIX1A PE=4 SV=1)

HSP 1 Score: 72.4034 bits (176), Expect = 4.516e-11
Identity = 32/87 (36.78%), Postives = 55/87 (63.22%), Query Frame = 2

Query: 1763 GNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            G+ + TK++YF+GKSP P +  IP+ L  +TL DVK    + + ++ N+RY FK    + G+ K+E+  D   VP  +GKI+ ++++
Sbjct:   71 GSPSSTKILYFIGKSPTPSMINIPKRLGEVTLKDVK----AAVDQEGNYRYHFKALDPEFGTVKEEVFLDGAIVPGWEGKIVAWLEE 153

[Close]

BLAST of DIX domain containing 1 vs. TrEMBL
Match: A0A3B4YI27 (DIX domain containing 1 OS=Seriola lalandi dorsalis OX=1841481 GN=DIXDC1 PE=4 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 7.489e-11
Identity = 32/87 (36.78%), Postives = 53/87 (60.92%), Query Frame = 2

Query: 1763 GNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            G+   TK++YF GKSP P +  IP+ L  +TL DVK    + + ++ N+RY FK    + G+ K+E+  D   VP  +GKI+ ++++
Sbjct:  227 GSSASTKILYFTGKSPTPSMINIPKRLGEVTLKDVK----AAVDREGNYRYHFKALDPEFGTVKEEVFLDGAIVPGWEGKIVAWVEE 309

[Close]

BLAST of DIX domain containing 1 vs. TrEMBL
Match: A0A3B5QSP0 (DIX domain containing 1 OS=Xiphophorus maculatus OX=8083 GN=DIXDC1 PE=4 SV=1)

HSP 1 Score: 76.2554 bits (186), Expect = 8.737e-11
Identity = 33/87 (37.93%), Postives = 54/87 (62.07%), Query Frame = 2

Query: 1763 GNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            G+ + TK++YF GKSP P +  IP+ L  +TL DVKE     + ++ N+RY FK    + G+ K+E+  D   VP  +GKI+ ++++
Sbjct:  341 GSPSSTKILYFTGKSPTPSMINIPKRLGEVTLKDVKE----AVDREGNYRYHFKALDPEFGTVKEEVFLDGAIVPGWEGKIVAWLEE 423

[Close]

BLAST of DIX domain containing 1 vs. TrEMBL
Match: A0A3B5MUH1 (DIX domain containing 1 OS=Xiphophorus couchianus OX=32473 GN=DIXDC1 PE=4 SV=1)

HSP 1 Score: 74.7146 bits (182), Expect = 9.499e-11
Identity = 35/95 (36.84%), Postives = 57/95 (60.00%), Query Frame = 2

Query: 1739 FISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            F  +  S G+ + TK++YF GKSP P +  IP+ L  +TL DVKE     + ++ N+RY FK    + G+ K+E+  D   VP  +GKI+ ++++
Sbjct:  216 FRKNLYSNGSPSSTKILYFTGKSPTPSMINIPKRLGEVTLKDVKE----AVDREGNYRYHFKALDPEFGTVKEEVFLDGAIVPGWEGKIVAWLEE 306

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Cavefish
Match: dixdc1a (DIX domain containing 1a [Source:NCBI gene;Acc:360137])

HSP 1 Score: 64.6994 bits (156), Expect = 1.454e-10
Identity = 30/98 (30.61%), Postives = 57/98 (58.16%), Query Frame = 2

Query: 1730 NNPFISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            ++P +S + S      TK++YF  +S  P++  IP+ L  +TL D K    + + +  NFRY FK+   + G+ K+E+ +D   +P  +GKI+ ++++
Sbjct:  309 SSPVLSTSAS------TKVLYFTDRSLTPFLINIPKRLGEVTLQDFK----AAVDRHGNFRYHFKSLDPEFGTVKEEVFQDEAIIPGWEGKIVAWVEE 396

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Cavefish
Match: dixdc1b (dixin-A [Source:NCBI gene;Acc:103030903])

HSP 1 Score: 62.3882 bits (150), Expect = 1.066e-9
Identity = 27/82 (32.93%), Postives = 49/82 (59.76%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++YF  +S  P++  IP+ L  +TL D K      + ++ +FRY FK    + G+ K+E+ +D   VP  +GKI+ ++++
Sbjct:  389 TKVLYFTDRSLTPFMINIPKRLGEVTLRDFK----VAIDREGSFRYHFKALDPEFGTVKEEVFQDDAVVPGWEGKIVAWVEE 466

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Cavefish
Match: dixdc1b (dixin-A [Source:NCBI gene;Acc:103030903])

HSP 1 Score: 62.003 bits (149), Expect = 1.776e-9
Identity = 27/82 (32.93%), Postives = 49/82 (59.76%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++YF  +S  P++  IP+ L  +TL D K      + ++ +FRY FK    + G+ K+E+ +D   VP  +GKI+ ++++
Sbjct:  611 TKVLYFTDRSLTPFMINIPKRLGEVTLRDFK----VAIDREGSFRYHFKALDPEFGTVKEEVFQDDAVVPGWEGKIVAWVEE 688

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Cavefish
Match: dixdc1b (dixin-A [Source:NCBI gene;Acc:103030903])

HSP 1 Score: 62.003 bits (149), Expect = 1.777e-9
Identity = 27/82 (32.93%), Postives = 49/82 (59.76%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++YF  +S  P++  IP+ L  +TL D K      + ++ +FRY FK    + G+ K+E+ +D   VP  +GKI+ ++++
Sbjct:  601 TKVLYFTDRSLTPFMINIPKRLGEVTLRDFK----VAIDREGSFRYHFKALDPEFGTVKEEVFQDDAVVPGWEGKIVAWVEE 678

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Cavefish
Match: dixdc1b (dixin-A [Source:NCBI gene;Acc:103030903])

HSP 1 Score: 61.2326 bits (147), Expect = 2.558e-9
Identity = 27/82 (32.93%), Postives = 49/82 (59.76%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++YF  +S  P++  IP+ L  +TL D K      + ++ +FRY FK    + G+ K+E+ +D   VP  +GKI+ ++++
Sbjct:  556 TKVLYFTDRSLTPFMINIPKRLGEVTLRDFK----VAIDREGSFRYHFKALDPEFGTVKEEVFQDDAVVPGWEGKIVAWVEE 633

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Medaka
Match: DIXDC1 (dixin-like [Source:NCBI gene;Acc:101159969])

HSP 1 Score: 72.0182 bits (175), Expect = 1.024e-12
Identity = 34/95 (35.79%), Postives = 57/95 (60.00%), Query Frame = 2

Query: 1751 TKSF----GNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK+F    G+ + TK++YF GKS  P +  IP+ L  +TL DVK    + + ++ N+RY FK    + G+ K+E+  D   VP  +GKI+ ++++
Sbjct:  398 TKTFKSHNGSTSSTKILYFTGKSMTPSMINIPKRLGEVTLRDVK----AAVDREGNYRYHFKALDPEFGTVKEEVFNDAALVPGWEGKIVAWLEE 488

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Medaka
Match: DIXDC1 (dixin-like [Source:NCBI gene;Acc:101159969])

HSP 1 Score: 71.633 bits (174), Expect = 1.648e-12
Identity = 34/95 (35.79%), Postives = 57/95 (60.00%), Query Frame = 2

Query: 1751 TKSF----GNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK+F    G+ + TK++YF GKS  P +  IP+ L  +TL DVK    + + ++ N+RY FK    + G+ K+E+  D   VP  +GKI+ ++++
Sbjct:  554 TKTFKSHNGSTSSTKILYFTGKSMTPSMINIPKRLGEVTLRDVK----AAVDREGNYRYHFKALDPEFGTVKEEVFNDAALVPGWEGKIVAWLEE 644

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Medaka
Match: dixdc1a (dixin-A-like [Source:NCBI gene;Acc:101166321])

HSP 1 Score: 65.855 bits (159), Expect = 6.652e-11
Identity = 28/82 (34.15%), Postives = 49/82 (59.76%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++YF  +S  P++  IP+ L  +TL D K    + + +  NFRY FK    + G+ K+E+ +D   VP  +GKI+ ++++
Sbjct:  330 TKVLYFTDRSLTPFLINIPKRLGEVTLRDFK----AAVDRQGNFRYHFKALDPEFGTVKEEVFQDSAVVPGWEGKIVAWVEE 407

[Close]

BLAST of DIX domain containing 1 vs. Ensembl Medaka
Match: dixdc1a (dixin-A-like [Source:NCBI gene;Acc:101166321])

HSP 1 Score: 65.0846 bits (157), Expect = 1.170e-10
Identity = 28/82 (34.15%), Postives = 49/82 (59.76%), Query Frame = 2

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++YF  +S  P++  IP+ L  +TL D K    + + +  NFRY FK    + G+ K+E+ +D   VP  +GKI+ ++++
Sbjct:  375 TKVLYFTDRSLTPFLINIPKRLGEVTLRDFK----AAVDRQGNFRYHFKALDPEFGTVKEEVFQDSAVVPGWEGKIVAWVEE 452

[Close]

Query: 1778 TKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            TK++YF  +S  P++  IP+ L  +TL D K    + + +  NFRY FK    + G+ K+E+ +D   VP  +GKI+ ++++
Sbjct:  375 TKVLYFTDRSLTPFLINIPKRLGEVTLRDFK----AAVDRQGNFRYHFKALDPEFGTVKEEVFQDSAVVPGWEGKIVAWVEE 452

[Close]

BLAST of DIX domain containing 1 vs. Planmine SMEST
Match: SMESG000033276.1 (SMESG000033276.1)

HSP 1 Score: 778.474 bits (2009), Expect = 0.000e+0
Identity = 405/406 (99.75%), Postives = 405/406 (99.75%), Query Frame = 2

Query:  806 MGPSQSHQHELASSDDGLSLFVPCHESTSSLASTDQRYDDVLTRNYQKHKNFKACRKLSKLRKSFSECFRSKFQQLKEETDIEQKPDSELISAQRPNSEMSNTVATESRDRRLSDSNDGVCQSFPKDIQEIHHQLNELKRLLSKPEIVNESIDKRDESCQTNKIDMIADHLLRQRDILIANQQDQLNNLRINLENXXXXXXXXXXXXXXXXXQQSRRSTDIDSKVLDQFILLLKSVRSERKLDNCDLDKFDEGINLMTLISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSENFDQQEKLNNPFISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            MGPSQSHQHELASSDDGLSLFVPCHESTSSLASTDQRYDDVLTRNYQKHKNFKACRKLSKLRKSFSECFRSKFQQLKEETDIEQKPDSELISAQRPNSEMSNTVATESRDRRLSDSNDGVCQSFPKDIQEIHHQLNELKRLLSKPEIVNESIDKRDESCQTNKIDMIADHLLRQRDILIANQQDQLNNLRINLENKVKVSESLLKELSILKSQQSRRSTDIDSKVLDQFILLLKSVRSERKLDNCDLDKFDEGINLMT ISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSENFDQQEKLNNPFISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ
Sbjct:    1 MGPSQSHQHELASSDDGLSLFVPCHESTSSLASTDQRYDDVLTRNYQKHKNFKACRKLSKLRKSFSECFRSKFQQLKEETDIEQKPDSELISAQRPNSEMSNTVATESRDRRLSDSNDGVCQSFPKDIQEIHHQLNELKRLLSKPEIVNESIDKRDESCQTNKIDMIADHLLRQRDILIANQQDQLNNLRINLENKVKVSESLLKELSILKSQQSRRSTDIDSKVLDQFILLLKSVRSERKLDNCDLDKFDEGINLMTSISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSENFDQQEKLNNPFISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 406

[Close]

BLAST of DIX domain containing 1 vs. Planmine SMEST
Match: SMESG000003898.1 (SMESG000003898.1)

HSP 1 Score: 770 bits (1987), Expect = 0.000e+0
Identity = 400/406 (98.52%), Postives = 403/406 (99.26%), Query Frame = 2

Query:  806 MGPSQSHQHELASSDDGLSLFVPCHESTSSLASTDQRYDDVLTRNYQKHKNFKACRKLSKLRKSFSECFRSKFQQLKEETDIEQKPDSELISAQRPNSEMSNTVATESRDRRLSDSNDGVCQSFPKDIQEIHHQLNELKRLLSKPEIVNESIDKRDESCQTNKIDMIADHLLRQRDILIANQQDQLNNLRINLENXXXXXXXXXXXXXXXXXQQSRRSTDIDSKVLDQFILLLKSVRSERKLDNCDLDKFDEGINLMTLISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSENFDQQEKLNNPFISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            MGPSQSHQHELASSDDGLSLFVPCHESTSSLASTDQRYDDVLTRNYQKHKNFKACRKLSKLRKSFSECFRSKFQQLKEETDIEQKPDSELISAQRPNSEMSNTVATESRDRRLSDSNDGVCQSFPKDIQEIHHQLNELKRLLSKPEIVNESIDKRDESCQTNK DMI+DHLLRQRDILIANQQDQLNNLRINLENKVKVSESLLKELSILKSQQSRRSTDIDSKVLDQFILLL+SVRSERKLDNCDLDKFDEGINLMT ISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSENFDQQEKLNNPFISD+KSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI Q
Sbjct:    1 MGPSQSHQHELASSDDGLSLFVPCHESTSSLASTDQRYDDVLTRNYQKHKNFKACRKLSKLRKSFSECFRSKFQQLKEETDIEQKPDSELISAQRPNSEMSNTVATESRDRRLSDSNDGVCQSFPKDIQEIHHQLNELKRLLSKPEIVNESIDKRDESCQTNKTDMISDHLLRQRDILIANQQDQLNNLRINLENKVKVSESLLKELSILKSQQSRRSTDIDSKVLDQFILLLQSVRSERKLDNCDLDKFDEGINLMTSISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSENFDQQEKLNNPFISDSKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFILQ 406

[Close]

BLAST of DIX domain containing 1 vs. Planmine SMEST
Match: SMESG000025925.1 (SMESG000025925.1)

HSP 1 Score: 55.0694 bits (131), Expect = 2.001e-7
Identity = 31/80 (38.75%), Postives = 46/80 (57.50%), Query Frame = 2

Query: 1790 YFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFK-TCSS-DMGSSKQEIIRDHDSVPIVDGKIIVFIQQ 2023
            Y++G  P+PY + IP     ITL   K    S+++K   FRYFFK  C   D G   +EIIRD   +P+ +GK++  I++
Sbjct:  702 YYIGNDPVPYRTQIPDS-QYITLGQFK----SLVAKKGPFRYFFKRYCDEFDCGVVHEEIIRDDAILPLWEGKVVAKIEK 776

[Close]

BLAST of DIX domain containing 1 vs. Planmine SMEST
Match: SMESG000049876.1 (SMESG000049876.1)

HSP 1 Score: 51.6026 bits (122), Expect = 2.433e-6
Identity = 25/81 (30.86%), Postives = 43/81 (53.09%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +T++IY++     PY+     P   ITL D K   N       N+++FFK+   D G  K+EI  D   +P V+G+++ ++
Sbjct:    3 ETRIIYYVDDEETPYLIKFHSPPEQITLGDFKNALNR-----PNYKFFFKSLDDDFGVVKEEITDDDAKLPYVNGRVVSWL 78

[Close]

BLAST of DIX domain containing 1 vs. Planmine SMEST
Match: SMESG000049876.1 (SMESG000049876.1)

HSP 1 Score: 51.2174 bits (121), Expect = 2.676e-6
Identity = 25/81 (30.86%), Postives = 43/81 (53.09%), Query Frame = 2

Query: 1775 DTKLIYFLGKSPIPYVSLIPQPLSAITLADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKIIVFI 2017
            +T++IY++     PY+     P   ITL D K   N       N+++FFK+   D G  K+EI  D   +P V+G+++ ++
Sbjct:    3 ETRIIYYVDDEETPYLIKFHSPPEQITLGDFKNALNR-----PNYKFFFKSLDDDFGVVKEEITDDDAKLPYVNGRVVSWL 78

The following BLAST results are available for this feature:

BLAST of DIX domain containing 1 vs. Ensembl Human
BLAST of DIX domain containing 1 vs. Ensembl Celegans
BLAST of DIX domain containing 1 vs. Ensembl Fly
BLAST of DIX domain containing 1 vs. Ensembl Zebrafish
BLAST of DIX domain containing 1 vs. Ensembl Xenopus
BLAST of DIX domain containing 1 vs. Ensembl Mouse
BLAST of DIX domain containing 1 vs. UniProt/SwissProt
BLAST of DIX domain containing 1 vs. TrEMBL
BLAST of DIX domain containing 1 vs. Ensembl Cavefish
BLAST of DIX domain containing 1 vs. Ensembl Sea Lamprey
BLAST of DIX domain containing 1 vs. Ensembl Yeast
BLAST of DIX domain containing 1 vs. Ensembl Nematostella
BLAST of DIX domain containing 1 vs. Ensembl Medaka
BLAST of DIX domain containing 1 vs. Planmine SMEST

BLAST of DIX domain containing 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
DIXDC1	2.618e-11	27.33	DIX domain containing 1 [Source:HGNC Symbol;Acc:HG...	[more]
DIXDC1	4.091e-11	27.33	DIX domain containing 1 [Source:HGNC Symbol;Acc:HG...	[more]
DVL2	1.458e-8	37.04	dishevelled segment polarity protein 2 [Source:HGN...	[more]
DVL2	7.106e-8	37.04	dishevelled segment polarity protein 2 [Source:HGN...	[more]
DVL2	7.255e-8	37.04	dishevelled segment polarity protein 2 [Source:HGN...	[more]

BLAST of DIX domain containing 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of DIX domain containing 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
dsh	3.311e-8	32.94	gene:FBgn0000499 transcript:FBtr0073454	[more]

BLAST of DIX domain containing 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dixdc1b	4.075e-10	32.93	DIX domain containing 1b [Source:ZFIN;Acc:ZDB-GENE...	[more]
dixdc1b	6.071e-10	32.93	DIX domain containing 1b [Source:ZFIN;Acc:ZDB-GENE...	[more]
dixdc1a	3.795e-9	30.49	DIX domain containing 1a [Source:NCBI gene;Acc:360...	[more]
dvl3b	4.284e-7	35.37	dishevelled segment polarity protein 3b [Source:ZF...	[more]
dvl3a	6.681e-7	34.57	dishevelled segment polarity protein 3a [Source:ZF...	[more]

BLAST of DIX domain containing 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSXETT00000001825.1	5.110e-11	29.90	pep primary_assembly:Xenopus_tropicalis_v9.1:KV461...	[more]
dvl3	3.497e-7	34.57	dishevelled segment polarity protein 3 [Source:NCB...	[more]
dvl3	3.918e-7	34.57	dishevelled segment polarity protein 3 [Source:NCB...	[more]
dvl3	3.942e-7	34.57	dishevelled segment polarity protein 3 [Source:NCB...	[more]
dvl3	3.993e-7	34.57	dishevelled segment polarity protein 3 [Source:NCB...	[more]

BLAST of DIX domain containing 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Dixdc1	6.714e-11	33.33	DIX domain containing 1 [Source:MGI Symbol;Acc:MGI...	[more]
Dixdc1	7.423e-11	33.33	DIX domain containing 1 [Source:MGI Symbol;Acc:MGI...	[more]
Dixdc1	8.659e-11	33.33	DIX domain containing 1 [Source:MGI Symbol;Acc:MGI...	[more]
Dvl2	4.417e-8	37.04	dishevelled segment polarity protein 2 [Source:MGI...	[more]
Dvl2	4.417e-8	37.04	dishevelled segment polarity protein 2 [Source:MGI...	[more]

BLAST of DIX domain containing 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q155Q3\|DIXC1_HUMAN	1.965e-10	27.33	Dixin OS=Homo sapiens OX=9606 GN=DIXDC1 PE=1 SV=2	[more]
sp\|Q80Y83\|DIXC1_MOUSE	5.193e-10	33.33	Dixin OS=Mus musculus OX=10090 GN=Dixdc1 PE=1 SV=1	[more]
sp\|Q2VUH7\|DIXC1_RAT	1.151e-8	33.33	Dixin OS=Rattus norvegicus OX=10116 GN=Dixdc1 PE=2...	[more]
sp\|Q804T6\|DIX1A_DANRE	2.915e-8	30.49	Dixin-A OS=Danio rerio OX=7955 GN=dixdc1a PE=1 SV=...	[more]
sp\|Q60838\|DVL2_MOUSE	3.090e-7	37.04	Segment polarity protein dishevelled homolog DVL-2...	[more]

BLAST of DIX domain containing 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A3B5MUH5	1.934e-11	37.93	DIX domain containing 1 OS=Xiphophorus couchianus ...	[more]
A0A0S7FKW8	4.516e-11	36.78	DIX1A (Fragment) OS=Poeciliopsis prolifica OX=1881...	[more]
A0A3B4YI27	7.489e-11	36.78	DIX domain containing 1 OS=Seriola lalandi dorsali...	[more]
A0A3B5QSP0	8.737e-11	37.93	DIX domain containing 1 OS=Xiphophorus maculatus O...	[more]
A0A3B5MUH1	9.499e-11	36.84	DIX domain containing 1 OS=Xiphophorus couchianus ...	[more]

BLAST of DIX domain containing 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dixdc1a	1.454e-10	30.61	DIX domain containing 1a [Source:NCBI gene;Acc:360...	[more]
dixdc1b	1.066e-9	32.93	dixin-A [Source:NCBI gene;Acc:103030903]	[more]
dixdc1b	1.776e-9	32.93	dixin-A [Source:NCBI gene;Acc:103030903]	[more]
dixdc1b	1.777e-9	32.93	dixin-A [Source:NCBI gene;Acc:103030903]	[more]
dixdc1b	2.558e-9	32.93	dixin-A [Source:NCBI gene;Acc:103030903]	[more]

BLAST of DIX domain containing 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of DIX domain containing 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of DIX domain containing 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of DIX domain containing 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
DIXDC1	1.024e-12	35.79	dixin-like [Source:NCBI gene;Acc:101159969]	[more]
DIXDC1	1.648e-12	35.79	dixin-like [Source:NCBI gene;Acc:101159969]	[more]
dixdc1a	6.652e-11	34.15	dixin-A-like [Source:NCBI gene;Acc:101166321]	[more]
dixdc1a	1.170e-10	34.15	dixin-A-like [Source:NCBI gene;Acc:101166321]	[more]
dixdc1a	1.170e-10	34.15	dixin-A-like [Source:NCBI gene;Acc:101166321]	[more]

BLAST of DIX domain containing 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000033276.1	0.000e+0	99.75	SMESG000033276.1	[more]
SMESG000003898.1	0.000e+0	98.52	SMESG000003898.1	[more]
SMESG000025925.1	2.001e-7	38.75	SMESG000025925.1	[more]
SMESG000049876.1	2.433e-6	30.86	SMESG000049876.1	[more]
SMESG000049876.1	2.676e-6	30.86	SMESG000049876.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30017209 ID=SMED30017209|Name=DIX domain containing 1|organism=Schmidtea mediterranea sexual|type=transcript|length=2178bp
CAACAATTCTTAATATTCCAAGAAAAATTGAAATCATTAACATTGCTTAA
GAAGGATTCACTATCCAAAATAAGCGCGTTCATTGGACCGTCGTACTGCG
CAAATAATTCAATTCACGCCATGAATCAACGCAATTCAGAACTCTGGATT
AGTCTATATTACATCAGTGCTTCATTATGATTTTTAACCGTGAAATGAAT
GATTTCCGTATATCTTTATATTACGGTCCCTTTGTAGTCACCTTGGCGTT
ATGATGGACAACTTTGGCCGAATTCCACAAATTCTTTATTCTGGTCAGGA
AATTATAATTTTTAACTTTTAACAGTCTTAGGACAGGTTGCTTGTCCATA
AAAATGGCAGTCTTAACTAATTCCATTGGGCAAGATGAATCCACATTACA
TGAAATATCCACCTTATGCGCTTCCATGTCATTCCTTTAAATATTATAAT
TACATTATGCAAAATAGTCAGTGATTCATATACAACTAGCAAAATTTTGC
CACATGCAGCAATATGGACAAATTAGAAATTAGATAATTCTATGATTTCC
ATAGTTGTAACTGATCGATTAGAATACTTTATTCGTTGTCGTTAAATTAG
GGCAGGAATTTAACACGGCTTCGCACACACACACACTCAGACTAACATTC
AACAAGATCCAATTGTGTGAATCGAGCCGGTGTGTCTCGCTACATTCTTA
CATGATTGGTGTGTTCTGCTGGCATTCTATCCTATATCTGTATAAGTTAT
AAACCGATCAGAAATTATTGATTTTTTTCCATTTGTACTCAAATCCGGTA
AAAGAATGGGTCCAAGCCAATCACATCAGCATGAATTAGCATCTTCTGAT
GACGGTTTAAGCTTGTTTGTTCCCTGTCACGAATCGACGTCTTCCCTAGC
TAGTACTGATCAGAGATATGATGATGTTCTCACACGAAATTATCAAAAGC
ACAAGAATTTTAAAGCATGTCGCAAACTTTCAAAACTACGAAAATCGTTT
TCTGAATGTTTTCGTTCTAAATTTCAACAATTAAAAGAAGAAACTGATAT
TGAACAAAAACCAGATAGCGAATTGATTTCTGCACAACGTCCAAATTCAG
AGATGTCAAATACTGTTGCTACTGAAAGTAGGGATCGTCGACTAAGCGAT
TCAAACGATGGAGTTTGCCAGAGCTTTCCCAAAGACATTCAAGAAATCCA
TCATCAATTGAATGAACTGAAAAGACTACTGTCCAAACCAGAGATTGTCA
ATGAATCTATTGACAAAAGAGATGAGTCTTGTCAAACGAATAAAATAGAC
ATGATTGCGGATCATCTACTGCGTCAGAGGGATATTCTAATAGCAAATCA
ACAAGATCAATTAAACAACCTCAGAATAAATCTAGAAAATAAAGTTAAAG
TTTCAGAATCTCTTTTAAAAGAACTATCAATTTTGAAATCACAACAATCT
CGACGTTCCACTGATATTGACTCGAAAGTGCTCGATCAATTTATACTATT
ATTAAAATCAGTCCGATCAGAACGCAAACTTGATAATTGTGATTTGGATA
AATTTGATGAAGGAATTAATCTGATGACATTAATATCAATCTCATCTCGA
TCTCAAAATGAAAAAGCAAATGTTGCCATAATAAATCCATGTTCAAAAAA
TAGCAAAGTGCTTTCAAAATTTGATAAAAAAATTTCATCTTCAGCTCTAT
CAGAAAATTTTGATCAACAAGAAAAGCTAAATAATCCTTTCATTTCTGAT
ACAAAATCTTTTGGAAACAAAACTGATACCAAATTAATTTATTTTCTAGG
CAAATCCCCTATTCCATATGTATCATTGATTCCGCAACCATTGAGCGCAA
TTACACTAGCTGATGTCAAAGAATACACGAATTCAGTATTATCCAAGGAC
ACTAATTTTCGATATTTCTTTAAAACGTGTAGTTCCGACATGGGCTCCTC
AAAACAAGAAATCATTCGTGATCATGATTCAGTCCCGATAGTCGATGGTA
AGATCATAGTATTTATTCAACAATGATTACTGGTCAGGTGACATTATTAT
GATGGAGGCGAATTATAATTTTTATGTGATGGAACATTTAATTTTTTTAA
TTTTATTGCTTTGGTTACTTTCAATATCGATTTAATTTTGTACCATGTTT
CATAAATGATTTTTAATTTTCTAAAAAA

protein sequence of SMED30017209-orf-1

>SMED30017209-orf-1 ID=SMED30017209-orf-1|Name=SMED30017209-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=407bp
MGPSQSHQHELASSDDGLSLFVPCHESTSSLASTDQRYDDVLTRNYQKHK
NFKACRKLSKLRKSFSECFRSKFQQLKEETDIEQKPDSELISAQRPNSEM
SNTVATESRDRRLSDSNDGVCQSFPKDIQEIHHQLNELKRLLSKPEIVNE
SIDKRDESCQTNKIDMIADHLLRQRDILIANQQDQLNNLRINLENKVKVS
ESLLKELSILKSQQSRRSTDIDSKVLDQFILLLKSVRSERKLDNCDLDKF
DEGINLMTLISISSRSQNEKANVAIINPCSKNSKVLSKFDKKISSSALSE
NFDQQEKLNNPFISDTKSFGNKTDTKLIYFLGKSPIPYVSLIPQPLSAIT
LADVKEYTNSVLSKDTNFRYFFKTCSSDMGSSKQEIIRDHDSVPIVDGKI
IVFIQQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000099	neuron
PLANA:0000101	muscle cell
PLANA:0003117	parapharyngeal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR038207	DIX_dom_sf
IPR015506	Dsh/Dvl-rel
IPR001158	DIX
IPR029071	Ubiquitin-like_domsf

Vocabulary: **biological process**
Term	Definition
GO:0016055	Wnt signaling pathway

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 179..199
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 78..117
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 90..104
None	No IPR available	PANTHER	PTHR10878:SF22	DIXIN	coord: 150..401
IPR001158	DIX domain	SMART	SM00021	dax_2	coord: 322..405 e-value: 7.8E-11 score: 52.0
IPR001158	DIX domain	PFAM	PF00778	DIX	coord: 324..405 e-value: 1.4E-18 score: 66.5
IPR001158	DIX domain	PROSITE	PS50841	DIX	coord: 322..406 score: 18.123
IPR038207	DIX domain superfamily	GENE3D	G3DSA:3.10.20.380		coord: 318..406 e-value: 1.3E-20 score: 74.9
IPR015506	Dishevelled-related protein	PANTHER	PTHR10878	SEGMENT POLARITY PROTEIN DISHEVELLED	coord: 150..401
IPR029071	Ubiquitin-like domain superfamily	SUPERFAMILY	SSF54236	Ubiquitin-like	coord: 325..405

Main menu

DIX domain containing 1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Owlery

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