Neuregulin 1

Overview
NameNeuregulin 1
Smed IDSMED30017199
Length (bp)1488
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Neuregulin 1 (SMED30017199) t-SNE clustered cells

Violin plots show distribution of expression levels for Neuregulin 1 (SMED30017199) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Neuregulin 1 (SMED30017199) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Neuregulin 1 (SMED30017199) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30017199

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30017199h1SMcG0018724 dd_Smed_v4_12297_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30017199h1SMcG0018724 dd_Smed_v4_12297_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30017199h1SMcG0018724 dd_Smed_v4_12297_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30017199h1SMcG0018724 dd_Smed_v4_12297_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30017199h1SMcG0018724 dd_Smed_v6_12297_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Neuregulin 1 vs. Ensembl Human
Match: MYPN (myopalladin [Source:HGNC Symbol;Acc:HGNC:23246])

HSP 1 Score: 58.151 bits (139), Expect = 3.594e-8
Identity = 36/113 (31.86%), Postives = 56/113 (49.56%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKST-YKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTM 495
            K  I APV  K   N   ++  EG L+  +C+  G P PK++WY  GT I+ S  ++ +Q + +       + TL+I +V     G F+C A N  G +S  A + V  N  +
Sbjct:  429 KPIIAAPVFTKMLQN---LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 538
[Close]
BLAST of Neuregulin 1 vs. Ensembl Human
Match: MYPN (myopalladin [Source:HGNC Symbol;Acc:HGNC:23246])

HSP 1 Score: 58.151 bits (139), Expect = 3.594e-8
Identity = 36/113 (31.86%), Postives = 56/113 (49.56%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKST-YKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTM 495
            K  I APV  K   N   ++  EG L+  +C+  G P PK++WY  GT I+ S  ++ +Q + +       + TL+I +V     G F+C A N  G +S  A + V  N  +
Sbjct:  429 KPIIAAPVFTKMLQN---LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 538
[Close]
BLAST of Neuregulin 1 vs. Ensembl Human
Match: MYPN (myopalladin [Source:HGNC Symbol;Acc:HGNC:23246])

HSP 1 Score: 57.7658 bits (138), Expect = 3.729e-8
Identity = 36/113 (31.86%), Postives = 55/113 (48.67%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKI-DKSTYKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTM 495
            K  I APV  K   N   ++  EG L+  +C+  G P PK++WY  GT I D   ++ +Q + +       + TL+I +V     G F+C A N  G +S  A + V  N  +
Sbjct:  135 KPIIAAPVFTKMLQN---LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 244
[Close]
BLAST of Neuregulin 1 vs. Ensembl Human
Match: MYPN (myopalladin [Source:HGNC Symbol;Acc:HGNC:23246])

HSP 1 Score: 57.7658 bits (138), Expect = 3.913e-8
Identity = 36/113 (31.86%), Postives = 56/113 (49.56%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKST-YKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTM 495
            K  I APV  K   N   ++  EG L+  +C+  G P PK++WY  GT I+ S  ++ +Q + +       + TL+I +V     G F+C A N  G +S  A + V  N  +
Sbjct:  154 KPIIAAPVFTKMLQN---LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 263
[Close]
BLAST of Neuregulin 1 vs. Ensembl Human
Match: PALLD (palladin, cytoskeletal associated protein [Source:HGNC Symbol;Acc:HGNC:17068])

HSP 1 Score: 53.1434 bits (126), Expect = 9.355e-7
Identity = 35/118 (29.66%), Postives = 63/118 (53.39%), Query Frame = 1 
Query:  190 APVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIK-GNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQ 540
            AP  I++   + E+   EG+ + ++C+  GNP P++ W+  G ++  +   DIQI  + G+L TLII +      G ++C+A N +G  +  A V +    + D+    S S+ F S+
Sbjct:  249 APRFIQK-LRSQEVA--EGSRVYLECRVTGNPTPRVRWFCEGKELHNT--PDIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDS---DSESLAFKSR 358
[Close]
BLAST of Neuregulin 1 vs. Ensembl Celegans
Match: igcm-4 (ImmunoGlobulin-like Cell adhesion Molecule family [Source:UniProtKB/TrEMBL;Acc:Q95XJ7])

HSP 1 Score: 53.5286 bits (127), Expect = 2.532e-7
Identity = 29/83 (34.94%), Postives = 45/83 (54.22%), Query Frame = 1 
Query:  229 ITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSV 477
            I +  G  L+++C A GNP+P+I WY N  +I + T+K        ++ST+ +  V + H G + C+  N  G LS    VSV
Sbjct:  161 IKINTGGKLELRCPAQGNPLPEIRWYQNEMEISEKTHK--------HVSTITVEPVESSHSGVYRCVVENPLGSLSFAFDVSV 235
[Close]
BLAST of Neuregulin 1 vs. Ensembl Celegans
Match: egl-15 (Myoblast growth factor receptor egl-15 [Source:UniProtKB/Swiss-Prot;Acc:Q10656])

HSP 1 Score: 50.447 bits (119), Expect = 2.585e-6
Identity = 29/87 (33.33%), Postives = 41/87 (47.13%), Query Frame = 1 
Query:  220 NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVM 480
            N    L  G  LK+ C+A G P P+I WY NG  + KS+ +    E K N  +L +        G F C A N  G   K+ +V ++
Sbjct:  299 NETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIV 385
[Close]
BLAST of Neuregulin 1 vs. Ensembl Celegans
Match: egl-15 (Myoblast growth factor receptor egl-15 [Source:UniProtKB/Swiss-Prot;Acc:Q10656])

HSP 1 Score: 50.447 bits (119), Expect = 2.655e-6
Identity = 29/87 (33.33%), Postives = 41/87 (47.13%), Query Frame = 1 
Query:  220 NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVM 480
            N    L  G  LK+ C+A G P P+I WY NG  + KS+ +    E K N  +L +        G F C A N  G   K+ +V ++
Sbjct:  299 NETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIV 385
[Close]
BLAST of Neuregulin 1 vs. Ensembl Celegans
Match: egl-15 (Myoblast growth factor receptor egl-15 [Source:UniProtKB/Swiss-Prot;Acc:Q10656])

HSP 1 Score: 50.447 bits (119), Expect = 2.807e-6
Identity = 29/87 (33.33%), Postives = 41/87 (47.13%), Query Frame = 1 
Query:  220 NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVM 480
            N    L  G  LK+ C+A G P P+I WY NG  + KS+ +    E K N  +L +        G F C A N  G   K+ +V ++
Sbjct:  299 NETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIV 385
[Close]
BLAST of Neuregulin 1 vs. Ensembl Celegans
Match: egl-15 (Myoblast growth factor receptor egl-15 [Source:UniProtKB/Swiss-Prot;Acc:Q10656])

HSP 1 Score: 50.447 bits (119), Expect = 2.807e-6
Identity = 29/87 (33.33%), Postives = 41/87 (47.13%), Query Frame = 1 
Query:  220 NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVM 480
            N    L  G  LK+ C+A G P P+I WY NG  + KS+ +    E K N  +L +        G F C A N  G   K+ +V ++
Sbjct:  299 NETHALPAGRTLKLNCRAKGYPEPQIIWYKNGKMLKKSSARSGGYEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIV 385
[Close]
BLAST of Neuregulin 1 vs. Ensembl Fly
Match: Pxn (gene:FBgn0011828 transcript:FBtr0072954)

HSP 1 Score: 64.3142 bits (155), Expect = 2.029e-10
Identity = 34/100 (34.00%), Postives = 55/100 (55.00%), Query Frame = 1 
Query:  187 DAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            + P ++  P +    T++ G    ++C ADGNP+P IDW LNG  +  +T  D+Q+E +   + L++G     H G + C AHN NG  S  A + V ++
Sbjct:  456 ELPEILTAPQSQ---TIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNT-PDLQLENEN--TELVVGAARQEHAGVYRCTAHNENGETSVEATIKVERS 549
[Close]
BLAST of Neuregulin 1 vs. Ensembl Fly
Match: Pxn (gene:FBgn0011828 transcript:FBtr0072951)

HSP 1 Score: 64.3142 bits (155), Expect = 2.029e-10
Identity = 34/100 (34.00%), Postives = 55/100 (55.00%), Query Frame = 1 
Query:  187 DAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            + P ++  P +    T++ G    ++C ADGNP+P IDW LNG  +  +T  D+Q+E +   + L++G     H G + C AHN NG  S  A + V ++
Sbjct:  456 ELPEILTAPQSQ---TIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNT-PDLQLENEN--TELVVGAARQEHAGVYRCTAHNENGETSVEATIKVERS 549
[Close]
BLAST of Neuregulin 1 vs. Ensembl Fly
Match: Pxn (gene:FBgn0011828 transcript:FBtr0072952)

HSP 1 Score: 64.3142 bits (155), Expect = 2.029e-10
Identity = 34/100 (34.00%), Postives = 55/100 (55.00%), Query Frame = 1 
Query:  187 DAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            + P ++  P +    T++ G    ++C ADGNP+P IDW LNG  +  +T  D+Q+E +   + L++G     H G + C AHN NG  S  A + V ++
Sbjct:  456 ELPEILTAPQSQ---TIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNT-PDLQLENEN--TELVVGAARQEHAGVYRCTAHNENGETSVEATIKVERS 549
[Close]
BLAST of Neuregulin 1 vs. Ensembl Fly
Match: Pxn (gene:FBgn0011828 transcript:FBtr0072953)

HSP 1 Score: 64.3142 bits (155), Expect = 2.029e-10
Identity = 34/100 (34.00%), Postives = 55/100 (55.00%), Query Frame = 1 
Query:  187 DAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            + P ++  P +    T++ G    ++C ADGNP+P IDW LNG  +  +T  D+Q+E +   + L++G     H G + C AHN NG  S  A + V ++
Sbjct:  456 ELPEILTAPQSQ---TIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNT-PDLQLENEN--TELVVGAARQEHAGVYRCTAHNENGETSVEATIKVERS 549
[Close]
BLAST of Neuregulin 1 vs. Ensembl Fly
Match: ihog (gene:FBgn0031872 transcript:FBtr0079365)

HSP 1 Score: 51.6026 bits (122), Expect = 1.448e-6
Identity = 33/91 (36.26%), Postives = 45/91 (49.45%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNG 447
            K  ++ P  I RP   +     EG+ LK++C+A G P P+I W LNG     S+  D + E+  N   LI+  V  RH G   C A N  G
Sbjct:  345 KVHVEQPPQIVRPPWAD--LTNEGDRLKLECKATGVPTPEIYWLLNG----HSSIDDSEAELSNNF--LILHSVLKRHAGYVQCFARNRLG 427
[Close]
BLAST of Neuregulin 1 vs. Ensembl Zebrafish
Match: nrg2b (neuregulin 2b [Source:ZFIN;Acc:ZDB-GENE-090205-2])

HSP 1 Score: 64.6994 bits (156), Expect = 8.047e-12
Identity = 45/138 (32.61%), Postives = 72/138 (52.17%), Query Frame = 1 
Query:  235 LQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR-SSTSVYFCSQETCVY----GSC--IRENNTSFCRCLPPYSGIRCE 627
            LQEG  L +KC+A GNP P  +WY +G+++ +   K ++I+     S L I KV     GN++C+  N+ G  +  ++VSV    ++ TT+   S+    C++    Y    G C  I   N   C+C   Y+G RC+
Sbjct:   14 LQEGKKLTLKCEAVGNPSPSFNWYKDGSQLRQK--KTVKIKTNKKNSKLHISKVRLEDSGNYTCVVENSLGRENATSFVSVQ---SITTTLSPGSSHARKCNETEKTYCINGGDCYFIHGINQLSCKCPNDYTGERCQ 146
[Close]
BLAST of Neuregulin 1 vs. Ensembl Zebrafish
Match: nrg2b (neuregulin 2b [Source:ZFIN;Acc:ZDB-GENE-090205-2])

HSP 1 Score: 67.3958 bits (163), Expect = 1.965e-11
Identity = 45/138 (32.61%), Postives = 72/138 (52.17%), Query Frame = 1 
Query:  235 LQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR-SSTSVYFCSQETCVY----GSC--IRENNTSFCRCLPPYSGIRCE 627
            LQEG  L +KC+A GNP P  +WY +G+++ +   K ++I+     S L I KV     GN++C+  N+ G  +  ++VSV    ++ TT+   S+    C++    Y    G C  I   N   C+C   Y+G RC+
Sbjct:   45 LQEGKKLTLKCEAVGNPSPSFNWYKDGSQLRQK--KTVKIKTNKKNSKLHISKVRLEDSGNYTCVVENSLGRENATSFVSVQ---SITTTLSPGSSHARKCNETEKTYCINGGDCYFIHGINQLSCKCPNDYTGERCQ 177
[Close]
BLAST of Neuregulin 1 vs. Ensembl Zebrafish
Match: nrg2b (neuregulin 2b [Source:ZFIN;Acc:ZDB-GENE-090205-2])

HSP 1 Score: 67.0106 bits (162), Expect = 2.531e-11
Identity = 45/138 (32.61%), Postives = 72/138 (52.17%), Query Frame = 1 
Query:  235 LQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR-SSTSVYFCSQETCVY----GSC--IRENNTSFCRCLPPYSGIRCE 627
            LQEG  L +KC+A GNP P  +WY +G+++ +   K ++I+     S L I KV     GN++C+  N+ G  +  ++VSV    ++ TT+   S+    C++    Y    G C  I   N   C+C   Y+G RC+
Sbjct:  151 LQEGKKLTLKCEAVGNPSPSFNWYKDGSQLRQK--KTVKIKTNKKNSKLHISKVRLEDSGNYTCVVENSLGRENATSFVSVQ---SITTTLSPGSSHARKCNETEKTYCINGGDCYFIHGINQLSCKCPNDYTGERCQ 283
[Close]
BLAST of Neuregulin 1 vs. Ensembl Zebrafish
Match: nrg2a (neuregulin 2a [Source:ZFIN;Acc:ZDB-GENE-070615-10])

HSP 1 Score: 61.6178 bits (148), Expect = 5.027e-10
Identity = 45/154 (29.22%), Postives = 71/154 (46.10%), Query Frame = 1 
Query:  223 NEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR-SSTSVYFCSQETCVY----GSC--IRENNTSFCRCLPPYSGIRCEYQPPEKVNFTEP 663
            N +   EG+ L +KC+A G+P P+  WY +G ++ +S  K+I+I      S + IG       GN++C+A N   +L K    S +   ++ TT+   S     C+     Y    G C  I   N   C+C   Y G RC    P ++   +P
Sbjct:    3 NPVLADEGSRLIVKCEATGSPAPEYKWYKDGAELKRS--KEIKIRNNKKNSKVQIGSAKLEDSGNYTCVAEN---ILGKANGTSTVHVQSITTTVSPGSGHARRCNDTEKTYCVNGGDCYYIHGINQLSCKCPDGYFGPRCLQTEPLRLYMPKP 151
[Close]
BLAST of Neuregulin 1 vs. Ensembl Zebrafish
Match: nrg2a (neuregulin 2a [Source:ZFIN;Acc:ZDB-GENE-070615-10])

HSP 1 Score: 62.3882 bits (150), Expect = 6.225e-10
Identity = 43/142 (30.28%), Postives = 68/142 (47.89%), Query Frame = 1 
Query:  223 NEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR-SSTSVYFCSQETCVY----GSC--IRENNTSFCRCLPPYSGIRCE 627
            N +   EG+ L +KC+A G+P P+  WY +G ++ +S  K+I+I      S + IG       GN++C+A N   +L K    S +   ++ TT+   S     C+     Y    G C  I   N   C+C   Y+G RC+
Sbjct:    3 NPVLADEGSRLIVKCEATGSPAPEYKWYKDGAELKRS--KEIKIRNNKKNSKVQIGSAKLEDSGNYTCVAEN---ILGKANGTSTVHVQSITTTVSPGSGHARRCNDTEKTYCVNGGDCYYIHGINQLSCKCPNDYTGDRCQ 139
[Close]
BLAST of Neuregulin 1 vs. Ensembl Xenopus
Match: MYPN (myopalladin [Source:NCBI gene;Acc:100495211])

HSP 1 Score: 63.929 bits (154), Expect = 4.900e-10
Identity = 37/101 (36.63%), Postives = 55/101 (54.46%), Query Frame = 1 
Query:  184 IDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            I APV  K   +  ++T  EG L+  + +  G+P PK++WY  GT I+ S   D +I  K  + TL+I +V +   G F+C A N  G  S  AY++V  N
Sbjct:  406 IAAPVFTK---SLQDLTACEGQLVVFESRVKGSPSPKVEWYREGTLIEDS--PDFRILQKKEICTLVIAEVFSEDSGMFTCTASNKYGTTSSIAYLTVKGN 501

HSP 2 Score: 52.373 bits (124), Expect = 1.926e-6
Identity = 32/98 (32.65%), Postives = 51/98 (52.04%), Query Frame = 1 
Query:  202 IKRPTN------NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSV 477
            + RP N      + E+T  EG+ +++ C   G P P++ WY  G +++ S   DIQI+  G+L +L+I +      G +SC A N  G  S  A + V
Sbjct:  249 VGRPPNFIQKLKSREVT--EGSKVQLDCIVVGFPPPEVRWYCEGKELENSP--DIQIQKSGDLDSLVITEAFEEDTGRYSCFASNIYGTDSTSAEIYV 342
[Close]
BLAST of Neuregulin 1 vs. Ensembl Xenopus
Match: lsamp (limbic system associated membrane protein [Source:NCBI gene;Acc:100124984])

HSP 1 Score: 56.9954 bits (136), Expect = 2.578e-8
Identity = 31/131 (23.66%), Postives = 66/131 (50.38%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQET-CVYGSC 564
            + T++ P +I    +N   T   G    ++C+A   P P  +WY + T+I+ +  + ++I   G+ S L++  V   H GN++C+A N  G+ +   Y+ +     +D+    + S++  +    C++ +C
Sbjct:  205 RVTVNYPPIITESKSNEATT---GKQAILRCEASAVPAPDFEWYKDDTRINSA--QGLEIRNTGSRSVLMVANVTEEHYGNYTCVAANKLGITNTSLYLYIGPGTPIDSATSLAASLWLMANLLFCLFCTC 330
[Close]
BLAST of Neuregulin 1 vs. Ensembl Xenopus
Match: MYPN (myopalladin [Source:NCBI gene;Acc:100495211])

HSP 1 Score: 57.3806 bits (137), Expect = 4.655e-8
Identity = 35/110 (31.82%), Postives = 57/110 (51.82%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKI-DKSTYKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            +  I APV  K   +  ++T  EG L+  + +  G+P PK++WY  GT I D   ++ +Q + +       + TL+I +V +   G F+C A N  G  S  AY++V  N
Sbjct:   75 RPLIAAPVFTK---SLQDLTACEGQLVVFESRVKGSPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFSEDSGMFTCTASNKYGTTSSIAYLTVKGN 181
[Close]
BLAST of Neuregulin 1 vs. Ensembl Xenopus
Match: MYPN (myopalladin [Source:NCBI gene;Acc:100495211])

HSP 1 Score: 57.3806 bits (137), Expect = 5.234e-8
Identity = 35/107 (32.71%), Postives = 56/107 (52.34%), Query Frame = 1 
Query:  184 IDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKI-DKSTYKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            I APV  K   +  ++T  EG L+  + +  G+P PK++WY  GT I D   ++ +Q + +       + TL+I +V +   G F+C A N  G  S  AY++V  N
Sbjct:  406 IAAPVFTK---SLQDLTACEGQLVVFESRVKGSPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFSEDSGMFTCTASNKYGTTSSIAYLTVKGN 509

HSP 2 Score: 52.373 bits (124), Expect = 1.847e-6
Identity = 32/98 (32.65%), Postives = 51/98 (52.04%), Query Frame = 1 
Query:  202 IKRPTN------NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSV 477
            + RP N      + E+T  EG+ +++ C   G P P++ WY  G +++ S   DIQI+  G+L +L+I +      G +SC A N  G  S  A + V
Sbjct:  249 VGRPPNFIQKLKSREVT--EGSKVQLDCIVVGFPPPEVRWYCEGKELENSP--DIQIQKSGDLDSLVITEAFEEDTGRYSCFASNIYGTDSTSAEIYV 342
[Close]
BLAST of Neuregulin 1 vs. Ensembl Xenopus
Match: MYPN (myopalladin [Source:NCBI gene;Acc:100495211])

HSP 1 Score: 57.3806 bits (137), Expect = 5.540e-8
Identity = 35/107 (32.71%), Postives = 57/107 (53.27%), Query Frame = 1 
Query:  184 IDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKS-TYKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            I APV  K   +  ++T  EG L+  + +  G+P PK++WY  GT I+ S  ++ +Q + +       + TL+I +V +   G F+C A N  G  S  AY++V  N
Sbjct:  385 IAAPVFTK---SLQDLTACEGQLVVFESRVKGSPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFSEDSGMFTCTASNKYGTTSSIAYLTVKGN 488

HSP 2 Score: 51.9878 bits (123), Expect = 2.131e-6
Identity = 32/98 (32.65%), Postives = 51/98 (52.04%), Query Frame = 1 
Query:  202 IKRPTN------NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSV 477
            + RP N      + E+T  EG+ +++ C   G P P++ WY  G +++ S   DIQI+  G+L +L+I +      G +SC A N  G  S  A + V
Sbjct:  259 VGRPPNFIQKLKSREVT--EGSKVQLDCIVVGFPPPEVRWYCEGKELENSP--DIQIQKSGDLDSLVITEAFEEDTGRYSCFASNIYGTDSTSAEIYV 352
[Close]
BLAST of Neuregulin 1 vs. Ensembl Mouse
Match: Mypn (myopalladin [Source:MGI Symbol;Acc:MGI:1916052])

HSP 1 Score: 57.7658 bits (138), Expect = 2.642e-8
Identity = 36/110 (32.73%), Postives = 56/110 (50.91%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKST-YKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            K  I APV  K   N   ++  EG L+  +C+  G P PK++WY  GT I+ S  ++ +Q + +       + TL+I +V +   G F+C A N  G +S  A + V  N
Sbjct:  426 KPIIAAPVFTKMLQN---LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFSEDSGCFTCTASNKYGTVSSIAQLDVRGN 532
[Close]
BLAST of Neuregulin 1 vs. Ensembl Mouse
Match: Ttn (titin [Source:MGI Symbol;Acc:MGI:98864])

HSP 1 Score: 54.6842 bits (130), Expect = 3.068e-7
Identity = 28/90 (31.11%), Postives = 46/90 (51.11%), Query Frame = 1 
Query:  229 ITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMD 498
            +T+ EG  + ++C   G P PK+ WY    +I+ S   D QI  +G ++ L+I +      G F+C A N  G +S   Y++V  +   D
Sbjct:  955 VTVIEGESVTLECHISGYPSPKVTWYREDYQIESSI--DFQITFQGGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFD 1042

HSP 2 Score: 50.8322 bits (120), Expect = 4.387e-6
Identity = 33/117 (28.21%), Postives = 51/117 (43.59%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSV 525
            K+T+ A +L    T    IT+ EG   +  C  DG P+P + W   G  +  ST    Q+      ST  I  V    EGN+S +  N++G       ++V K   ++  + S   V
Sbjct: 32599 KTTLAARIL----TKPRSITVHEGESARFSCDTDGEPVPTVTWLREGQVV--STSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSDGKQEAQFTLTVQKARVIEKAVTSPPRV 32709
[Close]
BLAST of Neuregulin 1 vs. Ensembl Mouse
Match: Ttn (titin [Source:MGI Symbol;Acc:MGI:98864])

HSP 1 Score: 54.6842 bits (130), Expect = 3.121e-7
Identity = 28/90 (31.11%), Postives = 46/90 (51.11%), Query Frame = 1 
Query:  229 ITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMD 498
            +T+ EG  + ++C   G P PK+ WY    +I+ S   D QI  +G ++ L+I +      G F+C A N  G +S   Y++V  +   D
Sbjct:  955 VTVIEGESVTLECHISGYPSPKVTWYREDYQIESSI--DFQITFQGGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFD 1042

HSP 2 Score: 50.8322 bits (120), Expect = 4.387e-6
Identity = 33/117 (28.21%), Postives = 51/117 (43.59%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSV 525
            K+T+ A +L    T    IT+ EG   +  C  DG P+P + W   G  +  ST    Q+      ST  I  V    EGN+S +  N++G       ++V K   ++  + S   V
Sbjct: 32599 KTTLAARIL----TKPRSITVHEGESARFSCDTDGEPVPTVTWLREGQVV--STSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSDGKQEAQFTLTVQKARVIEKAVTSPPRV 32709
[Close]
BLAST of Neuregulin 1 vs. Ensembl Mouse
Match: Ttn (titin [Source:MGI Symbol;Acc:MGI:98864])

HSP 1 Score: 53.9138 bits (128), Expect = 5.369e-7
Identity = 33/110 (30.00%), Postives = 54/110 (49.09%), Query Frame = 1 
Query:  184 IDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAY--VSVMKNYTMDTTI 507
            +  P L+    N   +T+ EG  + ++C   G P PK+ WY    +I+ S   D QI  +G ++ L+I +      G F+C A N  G +S   Y  V V + +  +TT+
Sbjct:  897 VTPPTLVSGLKN---VTVIEGESVTLECHISGYPSPKVTWYREDYQIESSI--DFQITFQGGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFDKETTL 1001
[Close]
BLAST of Neuregulin 1 vs. Ensembl Mouse
Match: Palld (palladin, cytoskeletal associated protein [Source:MGI Symbol;Acc:MGI:1919583])

HSP 1 Score: 53.5286 bits (127), Expect = 6.074e-7
Identity = 27/85 (31.76%), Postives = 45/85 (52.94%), Query Frame = 1 
Query:  193 PVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNG 447
            P  ++ P    ++T+QEG L ++ C+  G P P + W L+G  I   +   + +   G + +LII  V +R  G ++CIA N  G
Sbjct:  918 PHFLQAP---GDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENG-VHSLIIEPVTSRDAGIYTCIATNRAG 998

HSP 2 Score: 52.373 bits (124), Expect = 1.220e-6
Identity = 35/118 (29.66%), Postives = 62/118 (52.54%), Query Frame = 1 
Query:  190 APVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIK-GNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQ 540
            AP  I++   + E+   EG+ + ++C+  GNP P++ W+  G ++  S   D+QI  + G L TL+I +      G ++C+A N +G  S  A V +    + D+    S S+ F S+
Sbjct:  277 APRFIQK-LRSQEVA--EGSRVYLECRVTGNPTPRVRWFCEGKELYNS--PDVQIHCESGELHTLVIAEAFEDDTGRYTCLATNPSGSDSTSAEVFIEGASSTDS---DSESLSFISK 386
[Close]
BLAST of Neuregulin 1 vs. UniProt/SwissProt
Match: sp|Q9VZZ4|PXDN_DROME (Peroxidasin OS=Drosophila melanogaster OX=7227 GN=Pxn PE=1 SV=1)

HSP 1 Score: 64.3142 bits (155), Expect = 2.034e-9
Identity = 34/100 (34.00%), Postives = 55/100 (55.00%), Query Frame = 1 
Query:  187 DAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            + P ++  P +    T++ G    ++C ADGNP+P IDW LNG  +  +T  D+Q+E +   + L++G     H G + C AHN NG  S  A + V ++
Sbjct:  456 ELPEILTAPQSQ---TIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNT-PDLQLENEN--TELVVGAARQEHAGVYRCTAHNENGETSVEATIKVERS 549
[Close]
BLAST of Neuregulin 1 vs. UniProt/SwissProt
Match: sp|Q86TC9|MYPN_HUMAN (Myopalladin OS=Homo sapiens OX=9606 GN=MYPN PE=1 SV=2)

HSP 1 Score: 58.151 bits (139), Expect = 1.726e-7
Identity = 36/113 (31.86%), Postives = 56/113 (49.56%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKST-YKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTM 495
            K  I APV  K   N   ++  EG L+  +C+  G P PK++WY  GT I+ S  ++ +Q + +       + TL+I +V     G F+C A N  G +S  A + V  N  +
Sbjct:  429 KPIIAAPVFTKMLQN---LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 538
[Close]
BLAST of Neuregulin 1 vs. UniProt/SwissProt
Match: sp|Q5DTJ9|MYPN_MOUSE (Myopalladin OS=Mus musculus OX=10090 GN=Mypn PE=1 SV=2)

HSP 1 Score: 57.7658 bits (138), Expect = 1.848e-7
Identity = 36/110 (32.73%), Postives = 56/110 (50.91%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKST-YKDIQIEIKG-----NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            K  I APV  K   N   ++  EG L+  +C+  G P PK++WY  GT I+ S  ++ +Q + +       + TL+I +V +   G F+C A N  G +S  A + V  N
Sbjct:  426 KPIIAAPVFTKMLQN---LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFSEDSGCFTCTASNKYGTVSSIAQLDVRGN 532
[Close]
BLAST of Neuregulin 1 vs. UniProt/SwissProt
Match: sp|B4KJW1|IHOG_DROMO (Interference hedgehog OS=Drosophila mojavensis OX=7230 GN=iHog PE=3 SV=1)

HSP 1 Score: 53.5286 bits (127), Expect = 3.448e-6
Identity = 32/86 (37.21%), Postives = 45/86 (52.33%), Query Frame = 1 
Query:  190 APVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNG 447
            AP +++ P+ N      EG  + ++C A G P PKI W LNG   + S Y D + E+  N  +LI+ +V  RH G   C A N  G
Sbjct:  341 APRIVRPPSAN---LTNEGEFMVLECAATGTPTPKIYWLLNG---ENSVY-DTESELPAN-GSLILRRVQKRHAGCVQCFARNVLG 418
[Close]
BLAST of Neuregulin 1 vs. UniProt/SwissProt
Match: sp|B4HY03|IHOG_DROSE (Interference hedgehog OS=Drosophila sechellia OX=7238 GN=iHog PE=3 SV=1)

HSP 1 Score: 53.1434 bits (126), Expect = 4.638e-6
Identity = 33/91 (36.26%), Postives = 45/91 (49.45%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNG 447
            K  ++ P  I RP   +     EG+ LK++C+A G P P+I W LNG     S+  D + E+  N   LI+  V  RH G   C A N  G
Sbjct:  339 KVHVEQPPQIVRPPWAD--LTNEGDRLKLECEATGVPTPEIYWLLNG----HSSVDDTEAELSNNF--LILHSVLKRHAGYVQCFARNRLG 421
[Close]
BLAST of Neuregulin 1 vs. TrEMBL
Match: A0A3R7H6F9 (Uncharacterized protein OS=Clonorchis sinensis OX=79923 GN=CSKR_4922s PE=4 SV=1)

HSP 1 Score: 84.7297 bits (208), Expect = 1.121e-13
Identity = 45/145 (31.03%), Postives = 71/145 (48.97%), Query Frame = 1 
Query:  229 ITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEKVNFTEP 663
            + +Q+G +L +KC+  G   P I WY +G  I+   + +++I      S L +  V     GN+SCI  + N  LS+W YV+V+ +   +  +    +   C    C  G C+  NN   CRC P +SG RC ++     N  EP
Sbjct:    1 MEIQQGLMLNLKCRVQGERDPDIRWYKDGQLINPERHPNVEISSGVKRSQLRVRNVQLSDSGNYSCIGSSENAELSRWVYVTVLPSPD-ECKVADEKAYSPCPLNVCNSGKCLMINNQPVCRCPPTHSGPRCLHE-----NLPEP 139
[Close]
BLAST of Neuregulin 1 vs. TrEMBL
Match: A0A267EJI3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig018232g1 PE=4 SV=1)

HSP 1 Score: 81.6481 bits (200), Expect = 1.106e-12
Identity = 55/160 (34.38%), Postives = 74/160 (46.25%), Query Frame = 1 
Query:  220 NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGN------LSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYV---SVMKNYTMDTTIRSSTSVYFCSQETCVY-GSCIR-ENNTSFCRCLPPYSGIRCEYQPPEKVNFTEPC 666
            +N I + EG  L +KC+A G P PKI W   G  +      ++Q E   +      +STL I ++     GN++C A NN+G + KW YV   SV+      TT  +      C    C++ GSC        FC C  PY G RCE       NFTE C
Sbjct:   18 HNSIKIGEGKTLIVKCRARGKPNPKIVWSRGGRNLVMKENVNVQQEEHADQESQHLVSTLQISRISIGDSGNYTCKAENNHGSIQKWVYVAVQSVLPTLPFTTTSPAIVDDSACPPLYCLHNGSCSSYPGGIKFCNCTYPYHGDRCERNMMPYKNFTETC 177
[Close]
BLAST of Neuregulin 1 vs. TrEMBL
Match: A0A267H3A3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig018232g2 PE=4 SV=1)

HSP 1 Score: 81.6481 bits (200), Expect = 1.330e-12
Identity = 55/160 (34.38%), Postives = 74/160 (46.25%), Query Frame = 1 
Query:  220 NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGN------LSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYV---SVMKNYTMDTTIRSSTSVYFCSQETCVY-GSCIR-ENNTSFCRCLPPYSGIRCEYQPPEKVNFTEPC 666
            +N I + EG  L +KC+A G P PKI W   G  +      ++Q E   +      +STL I ++     GN++C A NN+G + KW YV   SV+      TT  +      C    C++ GSC        FC C  PY G RCE       NFTE C
Sbjct:   18 HNSIKIGEGKTLIVKCRARGKPNPKIVWSRGGRNLVMKENVNVQQEEHADQESQHLVSTLQISRISIGDSGNYTCKAENNHGSIQKWVYVAVQSVLPTLPFTTTSPAIVDDSACPPLYCLHNGSCSSYPGGIKFCNCTYPYHGDRCERNMMPYKNFTETC 177
[Close]
BLAST of Neuregulin 1 vs. TrEMBL
Match: W5ULJ7 (Pro-neuregulin-1, membrane-bound isoform OS=Ictalurus punctatus OX=7998 GN=NRG1 PE=2 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 3.120e-12
Identity = 57/173 (32.95%), Postives = 91/173 (52.60%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQA-DGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDT-TIRSSTSVYFCSQETCVY----GSCIRENNT-----SFCRCLPPYSGIRCEYQPPEKVNFTE 660
            KS I A   +K+ T+   + ++EG  + ++C+   G    KI W LNG KI K+  + I+++ KG +S L + KV     G + C A N+ G  ++ A V V+K  T  T + ++S+ +  C +E   Y    G C+  N T       CRCL  ++GIRCE + P +V+  E
Sbjct:   23 KSDIPATPKLKKLTD---VKVEEGQKVTLRCELLAGGKQTKILWSLNGKKIAKNETRRIKLKKKGTISELQLMKVTDADVGTYECKAVNDRGTDAQNASVQVIKAPTSTTASAKTSSHMTRCKEEEKSYCVNGGECLTVNVTPNSTKHLCRCLQGFTGIRCEIKEPVRVSNQE 192
[Close]
BLAST of Neuregulin 1 vs. TrEMBL
Match: A0A4S2M4L7 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_002851 PE=4 SV=1)

HSP 1 Score: 78.1814 bits (191), Expect = 1.497e-11
Identity = 44/159 (27.67%), Postives = 74/159 (46.54%), Query Frame = 1 
Query:  229 ITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEKVNFTEPCITFQNNKDHSFTE 705
            + + +G +L +KC+  G   P I WY +G  I+   + +++I      S L +  V     GN+SCI  + N  LS+W YV+V+ +   +  +    +   C    C  G C+  NN   CRC   +SG RC  +   + +   P I    ++D +  E
Sbjct:    1 MEIHQGLMLNLKCRVQGEREPDIRWYKDGQLINPERHPNVEISSGVKRSQLRVRNVQLSDSGNYSCIGSSENAELSRWVYVTVLPSPD-ERKVADEKAYSPCPLNICNSGKCVMINNQPVCRCPSTHSGPRCLQENLPEPSSAAPMILVTPSQDATTGE 158
[Close]
BLAST of Neuregulin 1 vs. Ensembl Cavefish
Match: nrg1 (neuregulin 1 [Source:NCBI gene;Acc:103034938])

HSP 1 Score: 67.0106 bits (162), Expect = 2.356e-11
Identity = 48/152 (31.58%), Postives = 74/152 (48.68%), Query Frame = 1 
Query:  229 ITLQEGNLLKIKCQ-ADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGN-LSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDT-TIRSSTSVYFCSQETCVY----GSCIRENNT-----SFCRCLPPYSGIRCEYQPPEKV 648
            + + EG  + +KC+   G    K++WY NG KI  +  + I+++ K   +S L + K      G + C A N+ G  S  A V+V+K  T  T + ++S+ V  CS+E   Y    G C     T       CRC P +SG RC+   P +V
Sbjct:   48 VDVPEGQKISLKCELTAGGKQTKLEWYHNGIKIGSNPTRQIKMKKKRRIMSELTLMKATESDVGTYMCKAINDQGQDSYEAKVTVLKAATSTTPSAKTSSHVTPCSEEERTYCVNGGDCFTLEVTPNSIKRLCRCPPGFSGDRCQNTEPVRV 199
[Close]
BLAST of Neuregulin 1 vs. Ensembl Cavefish
Match: ENSAMXT00000003826.2 (myopalladin [Source:NCBI gene;Acc:103025959])

HSP 1 Score: 67.3958 bits (163), Expect = 2.367e-11
Identity = 37/104 (35.58%), Postives = 56/104 (53.85%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            +  + APV  K   +  ++   EG L+ ++C+  G P P++DWY  G  ID S   D +I  K N+ TL+I +V T   G F+C A N  G +S  A ++V  N
Sbjct:  495 RPIMAAPVFTK---SLQDLVASEGQLVVLECRVKGVPSPRVDWYREGMLIDDS--PDFRILQKKNICTLVIAEVFTEDSGMFTCTASNKYGTVSSVALLTVNGN 593
[Close]
BLAST of Neuregulin 1 vs. Ensembl Cavefish
Match: nrg1 (neuregulin 1 [Source:NCBI gene;Acc:103034938])

HSP 1 Score: 67.0106 bits (162), Expect = 2.413e-11
Identity = 48/152 (31.58%), Postives = 74/152 (48.68%), Query Frame = 1 
Query:  229 ITLQEGNLLKIKCQ-ADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGN-LSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDT-TIRSSTSVYFCSQETCVY----GSCIRENNT-----SFCRCLPPYSGIRCEYQPPEKV 648
            + + EG  + +KC+   G    K++WY NG KI  +  + I+++ K   +S L + K      G + C A N+ G  S  A V+V+K  T  T + ++S+ V  CS+E   Y    G C     T       CRC P +SG RC+   P +V
Sbjct:   47 VDVPEGQKISLKCELTAGGKQTKLEWYHNGIKIGSNPTRQIKMKKKRRIMSELTLMKATESDVGTYMCKAINDQGQDSYEAKVTVLKAATSTTPSAKTSSHVTPCSEEERTYCVNGGDCFTLEVTPNSIKRLCRCPPGFSGDRCQNTEPVRV 198
[Close]
BLAST of Neuregulin 1 vs. Ensembl Cavefish
Match: nrg2b (pro-neuregulin-2, membrane-bound isoform-like [Source:NCBI gene;Acc:103042778])

HSP 1 Score: 66.6254 bits (161), Expect = 3.786e-11
Identity = 42/136 (30.88%), Postives = 73/136 (53.68%), Query Frame = 1 
Query:  241 EGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR-SSTSVYFCSQETCVY----GSC--IRENNTSFCRCLPPYSGIRCE 627
            EG+ + +KC+A GNP P   W+ +G+++ KS  KD++I+     S + I +V     GN++C+A N+ G  +  +Y++V    ++ TT+   S+    C++    Y    G C  I   N   C+C   Y+G RC+
Sbjct:  282 EGDRVTLKCEAQGNPSPSFRWFKDGSELRKS--KDVKIKTNKKNSKIQISRVRLEDSGNYTCVAENSLGKENSTSYINVQ---SITTTLSPGSSHARKCNETEKAYCVNGGDCYFIHGINQLSCKCPNDYTGDRCQ 412
[Close]
BLAST of Neuregulin 1 vs. Ensembl Cavefish
Match: nrg2b (pro-neuregulin-2, membrane-bound isoform-like [Source:NCBI gene;Acc:103042778])

HSP 1 Score: 66.2402 bits (160), Expect = 4.183e-11
Identity = 42/136 (30.88%), Postives = 73/136 (53.68%), Query Frame = 1 
Query:  241 EGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR-SSTSVYFCSQETCVY----GSC--IRENNTSFCRCLPPYSGIRCE 627
            EG+ + +KC+A GNP P   W+ +G+++ KS  KD++I+     S + I +V     GN++C+A N+ G  +  +Y++V    ++ TT+   S+    C++    Y    G C  I   N   C+C   Y+G RC+
Sbjct:  282 EGDRVTLKCEAQGNPSPSFRWFKDGSELRKS--KDVKIKTNKKNSKIQISRVRLEDSGNYTCVAENSLGKENSTSYINVQ---SITTTLSPGSSHARKCNETEKAYCVNGGDCYFIHGINQLSCKCPNDYTGDRCQ 412
[Close]
BLAST of Neuregulin 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002502.1 (pep scaffold:Pmarinus_7.0:GL476400:249000:366561:-1 gene:ENSPMAG00000002253.1 transcript:ENSPMAT00000002502.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 51.2174 bits (121), Expect = 5.876e-7
Identity = 26/84 (30.95%), Postives = 45/84 (53.57%), Query Frame = 1 
Query:  226 EITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSV 477
            + T+ EG  ++++CQ  G P P I W+    +I++S   D QI  +  +++L I +      G F+C A N  G +S  +Y+ V
Sbjct:  385 DTTVVEGESVRMECQVAGFPTPAIMWFREEYRIERSA--DFQIAFQAGVASLTIREAFAEDSGRFTCTATNEAGTVSTSSYLLV 466

HSP 2 Score: 47.3654 bits (111), Expect = 8.752e-6
Identity = 25/69 (36.23%), Postives = 37/69 (53.62%), Query Frame = 1 
Query:  241 EGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNG 447
            EG  +   C+  G+P+PKI WY NG ++  S    I+   +G L +L I  V   HEG ++ +A N  G
Sbjct:  712 EGMTVTYHCKVSGSPLPKITWYKNGQRVRASERNHIESSGEG-LHSLRIPLVQAEHEGVYTVLASNARG 779
[Close]
BLAST of Neuregulin 1 vs. Ensembl Sea Lamprey
Match: nfasca (neurofascin homolog (chicken) a [Source:ZFIN;Acc:ZDB-GENE-080229-6])

HSP 1 Score: 50.447 bits (119), Expect = 8.856e-7
Identity = 24/69 (34.78%), Postives = 40/69 (57.97%), Query Frame = 1 
Query:  253 LKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVG----TRHEGNFSCIAHNNNG 447
            ++IKC+A GNP P   W  +G  +D     D +++++G+  TL++  VG     R+EG + C A N+ G
Sbjct:   27 IEIKCEAKGNPPPSFHWTKDG--VDFHPEADERVQMRGDSGTLVVDVVGGGRAERYEGEYQCRASNSGG 93
[Close]
BLAST of Neuregulin 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005837.1 (pep scaffold:Pmarinus_7.0:GL476948:9490:27870:1 gene:ENSPMAG00000005284.1 transcript:ENSPMAT00000005837.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 46.9802 bits (110), Expect = 2.571e-6
Identity = 26/84 (30.95%), Postives = 40/84 (47.62%), Query Frame = 1 
Query:  226 EITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKG-------NLSTLIIGKVGTRHEGNFSCIAHNNNGLLS 456
            + T  EG L+ ++C+  G+P PKI WY   T +D S    + ++ K         + TLII +      G F C A +  G +S
Sbjct:    3 DATASEGQLVVLECRVKGSPAPKITWYREDTAVDDSPDFRLLLQKKPRSVAEPEEICTLIISEAFPEDSGTFRCTASSKLGTVS 86
[Close]
BLAST of Neuregulin 1 vs. Ensembl Nematostella
Match: EDO43171 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZN6])

HSP 1 Score: 54.299 bits (129), Expect = 7.265e-8
Identity = 32/101 (31.68%), Postives = 56/101 (55.45%), Query Frame = 1 
Query:  184 IDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKN 486
            + APV  +R      I L+EG+ LK++C A+G+P PKI W+ NG K+   + +   + ++G +  L I  +     G ++CI  N +G + +   VS +K+
Sbjct:  158 VQAPVF-RRNIKALRIRLEEGSQLKLRCHANGSPQPKIQWHHNGKKL--RSRRRNHVILRGWV--LNIRSLRQSDSGRYTCIVKNKHGTIRRTYIVSPLKS 253
[Close]
BLAST of Neuregulin 1 vs. Ensembl Nematostella
Match: EDO48179 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RK32])

HSP 1 Score: 54.299 bits (129), Expect = 8.955e-8
Identity = 29/104 (27.88%), Postives = 53/104 (50.96%), Query Frame = 1 
Query:  172 RKSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMK 483
            R   ++ PVL ++P   +++++  G L+K+ C A G P+P I W +   K      ++ +IE   +    II        G ++C A N  G ++  AYV+V++
Sbjct:  633 RLEVLEFPVLTRKP---HDVSVHVGGLIKLPCAATGYPVPVISWRMGDGKSKFPAAEEKRIEHLPSEHLFIIRNARGVDTGAYTCTATNGAGSINATAYVTVLE 733
[Close]
BLAST of Neuregulin 1 vs. Ensembl Nematostella
Match: EDO30625 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T084])

HSP 1 Score: 51.2174 bits (121), Expect = 4.170e-7
Identity = 28/76 (36.84%), Postives = 41/76 (53.95%), Query Frame = 1 
Query:  220 NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNG 447
            N  +  + G+ +++ CQA G+P PK  W  NG  I  S  K++Q+E    L  LI+ KV     G + CIA+N  G
Sbjct:  187 NKTLVAERGSNVQLSCQASGDPTPKYKWTYNGVPI--SPRKNVQLEDDNRL--LILKKVSPVSNGVYRCIAYNTEG 258
[Close]
BLAST of Neuregulin 1 vs. Ensembl Nematostella
Match: EDO49558 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGM2])

HSP 1 Score: 48.9062 bits (115), Expect = 4.106e-6
Identity = 21/85 (24.71%), Postives = 45/85 (52.94%), Query Frame = 1 
Query:  226 EITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVM 480
            +I + EGN + ++    G+P P++DW+ +G  +    ++  ++   G + TL+I +      G + C A+N+ G ++    V V+
Sbjct:   11 DIEVNEGNTVTLRIHVTGSPKPEVDWFKDGKPVSGLPHRRFEVGCVGEVYTLVIKEARGSDTGKYLCKAYNSAGEVTSSCNVDVL 95
[Close]
BLAST of Neuregulin 1 vs. Ensembl Nematostella
Match: EDO49553 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGL7])

HSP 1 Score: 48.521 bits (114), Expect = 4.548e-6
Identity = 24/87 (27.59%), Postives = 44/87 (50.57%), Query Frame = 1 
Query:  229 ITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNY 489
            I + EG+  ++ C   G P P++ W+ +   I  S  +  +    GN+S L + +     +G + C+  NN G +S  A V+V+K +
Sbjct:   25 IEITEGDDFQLSCNVTGRPQPEVQWFRDEVLIKPS--RRFKASYDGNVSALTVKEAELDDDGVYKCVVTNNFGSVSSKADVTVLKKH 109
[Close]
BLAST of Neuregulin 1 vs. Ensembl Medaka
Match: nrg2b (pro-neuregulin-2, membrane-bound isoform [Source:NCBI gene;Acc:101159516])

HSP 1 Score: 60.8474 bits (146), Expect = 2.196e-9
Identity = 44/140 (31.43%), Postives = 68/140 (48.57%), Query Frame = 1 
Query:  235 LQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYF---CSQETCVY----GSC--IRENNTSFCRCLPPYSGIRCE 627
            L EG+ L +KC+A GNP P   WY +G ++ K   +D++I+     S + I +V     GN++C+A N+ G  +  + ++V     + TT   S  V     C+     Y    G C  I   N   C+C   Y+G RCE
Sbjct:  151 LMEGDKLYLKCEALGNPSPSFRWYKDGRELQKG--RDLKIKTNKKNSKVQISRVRLEDAGNYTCVAENSLGQENATSIITVQ----ILTTTNPSPGVSHARRCNDSEKAYCVNGGDCYFIHGINHLSCKCPNDYTGDRCE 284
[Close]
BLAST of Neuregulin 1 vs. Ensembl Medaka
Match: nrg2b (pro-neuregulin-2, membrane-bound isoform [Source:NCBI gene;Acc:101159516])

HSP 1 Score: 60.8474 bits (146), Expect = 2.281e-9
Identity = 44/140 (31.43%), Postives = 68/140 (48.57%), Query Frame = 1 
Query:  235 LQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYF---CSQETCVY----GSC--IRENNTSFCRCLPPYSGIRCE 627
            L EG+ L +KC+A GNP P   WY +G ++ K   +D++I+     S + I +V     GN++C+A N+ G  +  + ++V     + TT   S  V     C+     Y    G C  I   N   C+C   Y+G RCE
Sbjct:  151 LMEGDKLYLKCEALGNPSPSFRWYKDGRELQKG--RDLKIKTNKKNSKVQISRVRLEDAGNYTCVAENSLGQENATSIITVQ----ILTTTNPSPGVSHARRCNDSEKAYCVNGGDCYFIHGINHLSCKCPNDYTGDRCE 284
[Close]
BLAST of Neuregulin 1 vs. Ensembl Medaka
Match: MYPN (myopalladin [Source:NCBI gene;Acc:101175503])

HSP 1 Score: 58.151 bits (139), Expect = 1.579e-8
Identity = 36/112 (32.14%), Postives = 59/112 (52.68%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR 510
            +  + APV  K   N  ++   +G L+ ++C+  G P PK+DW+  G  ++ S   D +I  K ++ TL+I +V     G F+CIA N  G +S  A + V  + +  T IR
Sbjct:  558 RPVMAAPVFTK---NLLDLAASQGQLVVLECRVKGVPAPKVDWFREGKVLEDS--PDFRILQKKDICTLVIAEVFAEDSGMFTCIASNKYGTVSSSAALKVKGDGSNITHIR 664
[Close]
BLAST of Neuregulin 1 vs. Ensembl Medaka
Match: MYPN (myopalladin [Source:NCBI gene;Acc:101175503])

HSP 1 Score: 58.151 bits (139), Expect = 1.616e-8
Identity = 36/112 (32.14%), Postives = 59/112 (52.68%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR 510
            +  + APV  K   N  ++   +G L+ ++C+  G P PK+DW+  G  ++ S   D +I  K ++ TL+I +V     G F+CIA N  G +S  A + V  + +  T IR
Sbjct:  558 RPVMAAPVFTK---NLLDLAASQGQLVVLECRVKGVPAPKVDWFREGKVLEDS--PDFRILQKKDICTLVIAEVFAEDSGMFTCIASNKYGTVSSSAALKVKGDGSNITHIR 664
[Close]
BLAST of Neuregulin 1 vs. Ensembl Medaka
Match: MYPN (myopalladin [Source:NCBI gene;Acc:101175503])

HSP 1 Score: 58.151 bits (139), Expect = 1.620e-8
Identity = 36/112 (32.14%), Postives = 59/112 (52.68%), Query Frame = 1 
Query:  175 KSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIR 510
            +  + APV  K   N  ++   +G L+ ++C+  G P PK+DW+  G  ++ S   D +I  K ++ TL+I +V     G F+CIA N  G +S  A + V  + +  T IR
Sbjct:  558 RPVMAAPVFTK---NLLDLAASQGQLVVLECRVKGVPAPKVDWFREGKVLEDS--PDFRILQKKDICTLVIAEVFAEDSGMFTCIASNKYGTVSSSAALKVKGDGSNITHIR 664
[Close]
BLAST of Neuregulin 1 vs. Planmine SMEST
Match: SMESG000026010.1 (SMESG000026010.1)

HSP 1 Score: 813.913 bits (2101), Expect = 0.000e+0
Identity = 425/425 (100.00%), Postives = 425/425 (100.00%), Query Frame = 1 
Query:  169 MRKSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEKVNFTEPCITFQNNKDHSFTENKXXXXXXXXXXXXXXXXXXXXXCFYKFRKRRSYIHGIKAKKLKNAATQVSDIFYSDLNISQIPDNISSSILNTEKSFLSSCVYNEAPPYNSLVIQKDSRGPPSGQSCSSQDTSLTNTVVIPKSILLSVNDNSYSLYNSSTMNNNYCHTQLPPQMIRLENTSPYLCPALETETNLSLNNYIGNIISLPFSCNDPCCCLNVDSKNLLTPTLQNNVSKPSLISIHSNPMESDHICTCKCNIQSINTFV 1443
            MRKSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEKVNFTEPCITFQNNKDHSFTENKLFALISFSLLLVLVLLLIILLCFYKFRKRRSYIHGIKAKKLKNAATQVSDIFYSDLNISQIPDNISSSILNTEKSFLSSCVYNEAPPYNSLVIQKDSRGPPSGQSCSSQDTSLTNTVVIPKSILLSVNDNSYSLYNSSTMNNNYCHTQLPPQMIRLENTSPYLCPALETETNLSLNNYIGNIISLPFSCNDPCCCLNVDSKNLLTPTLQNNVSKPSLISIHSNPMESDHICTCKCNIQSINTFV
Sbjct:    1 MRKSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEKVNFTEPCITFQNNKDHSFTENKLFALISFSLLLVLVLLLIILLCFYKFRKRRSYIHGIKAKKLKNAATQVSDIFYSDLNISQIPDNISSSILNTEKSFLSSCVYNEAPPYNSLVIQKDSRGPPSGQSCSSQDTSLTNTVVIPKSILLSVNDNSYSLYNSSTMNNNYCHTQLPPQMIRLENTSPYLCPALETETNLSLNNYIGNIISLPFSCNDPCCCLNVDSKNLLTPTLQNNVSKPSLISIHSNPMESDHICTCKCNIQSINTFV 425
[Close]
BLAST of Neuregulin 1 vs. Planmine SMEST
Match: SMESG000026010.1 (SMESG000026010.1)

HSP 1 Score: 801.586 bits (2069), Expect = 0.000e+0
Identity = 419/421 (99.52%), Postives = 420/421 (99.76%), Query Frame = 1 
Query:  181 TIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEKVNFTEPCITFQNNKDHSFTENKXXXXXXXXXXXXXXXXXXXXXCFYKFRKRRSYIHGIKAKKLKNAATQVSDIFYSDLNISQIPDNISSSILNTEKSFLSSCVYNEAPPYNSLVIQKDSRGPPSGQSCSSQDTSLTNTVVIPKSILLSVNDNSYSLYNSSTMNNNYCHTQLPPQMIRLENTSPYLCPALETETNLSLNNYIGNIISLPFSCNDPCCCLNVDSKNLLTPTLQNNVSKPSLISIHSNPMESDHICTCKCNIQSINTFV 1443
            +I APVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEKVNFTEPCITFQNNKDHSFTENKLFALISFSLLLVLVLLLIILLCFYKFRKRRSYIHGIKAKKLKNAATQVSDIFYSDLNISQIPDNISSSILNTEKSFLSSCVYNEAPPYNSLVIQKDSRGPPSGQSCSSQDTSLTNTVVIPKSILLSVNDNSYSLYNSSTMNNNYCHTQLPPQMIRLENTSPYLCPALETETNLSLNNYIGNIISLPFSCNDPCCCLNVDSKNLLTPTLQNNVSKPSLISIHSNPMESDHICTCKCNIQSINTFV
Sbjct:   29 SIYAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEKVNFTEPCITFQNNKDHSFTENKLFALISFSLLLVLVLLLIILLCFYKFRKRRSYIHGIKAKKLKNAATQVSDIFYSDLNISQIPDNISSSILNTEKSFLSSCVYNEAPPYNSLVIQKDSRGPPSGQSCSSQDTSLTNTVVIPKSILLSVNDNSYSLYNSSTMNNNYCHTQLPPQMIRLENTSPYLCPALETETNLSLNNYIGNIISLPFSCNDPCCCLNVDSKNLLTPTLQNNVSKPSLISIHSNPMESDHICTCKCNIQSINTFV 449
[Close]
BLAST of Neuregulin 1 vs. Planmine SMEST
Match: SMESG000023969.1 (SMESG000023969.1)

HSP 1 Score: 66.6254 bits (161), Expect = 3.988e-12
Identity = 38/143 (26.57%), Postives = 65/143 (45.45%), Query Frame = 1 
Query:  217 NNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEK 645
            N++ + L E     + C+A G PIP +DWY N   I    Y         + + L++  +     G + C A N+ G + KW  ++V    +M   ++       C  + C++G C  + N   C+C   Y+GIRC+ +   K
Sbjct:   23 NDDTVDLFENENPLLNCEAIGQPIPTVDWYENRKIIFGRKY----FLKNKSCNQLLLRNISMIDAGMYVCRASNSQGYVKKWMNINVFPKSSMYWWLKQK-----CHDQYCIHGDCYFDRNIRVCKCHHSYTGIRCDEKTHSK 156
[Close]
BLAST of Neuregulin 1 vs. Planmine SMEST
Match: SMESG000023969.1 (SMESG000023969.1)

HSP 1 Score: 66.6254 bits (161), Expect = 3.992e-12
Identity = 38/143 (26.57%), Postives = 65/143 (45.45%), Query Frame = 1 
Query:  217 NNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGIRCEYQPPEK 645
            N++ + L E     + C+A G PIP +DWY N   I    Y         + + L++  +     G + C A N+ G + KW  ++V    +M   ++       C  + C++G C  + N   C+C   Y+GIRC+ +   K
Sbjct:   23 NDDTVDLFENENPLLNCEAIGQPIPTVDWYENRKIIFGRKY----FLKNKSCNQLLLRNISMIDAGMYVCRASNSQGYVKKWMNINVFPKSSMYWWLKQK-----CHDQYCIHGDCYFDRNIRVCKCHHSYTGIRCDEKTHSK 156
[Close]
BLAST of Neuregulin 1 vs. Planmine SMEST
Match: SMESG000028939.1 (SMESG000028939.1)

HSP 1 Score: 60.4622 bits (145), Expect = 1.129e-9
Identity = 46/167 (27.54%), Postives = 76/167 (45.51%), Query Frame = 1 
Query:  220 NNEITLQEGNLLKIKCQADGNPIPKIDWYLNGTKIDKSTYKDIQIEIKG--NLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAYVSVMKNYTMDTTIRSSTSVY----------FC-SQETCVYGSCIRENNT------SFCRCLPPYSGIRCEYQPPEKVNFTEP 663
            N+ + + EG    + C   G+P P+I WY N   +D+  ++    + K   N S L      +   GN++C A N +G + K  +V +M+   + TT + S+SV            C S   C+ G C+   +T      ++C+C   +SG+ CE     KV F  P
Sbjct:   44 NHGVKITEGESFTLICSVIGDPTPRIFWYHNNQLVDRQWFRYTNHDDKNSRNTSELKFQFAKSNLTGNYTCHAENTHGHVRKSVFVKIME---IPTTTKGSSSVTSNSLKIDNRSGCDSDRDCIPGRCLTSIDTETKKIKNYCQCPIRFSGLHCE----TKVEFERP 203
The following BLAST results are available for this feature:
BLAST of Neuregulin 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MYPN3.594e-831.86myopalladin [Source:HGNC Symbol;Acc:HGNC:23246][more]
MYPN3.594e-831.86myopalladin [Source:HGNC Symbol;Acc:HGNC:23246][more]
MYPN3.729e-831.86myopalladin [Source:HGNC Symbol;Acc:HGNC:23246][more]
MYPN3.913e-831.86myopalladin [Source:HGNC Symbol;Acc:HGNC:23246][more]
PALLD9.355e-729.66palladin, cytoskeletal associated protein [Source:... [more]
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BLAST of Neuregulin 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
igcm-42.532e-734.94ImmunoGlobulin-like Cell adhesion Molecule family ... [more]
egl-152.585e-633.33Myoblast growth factor receptor egl-15 [Source:Un... [more]
egl-152.655e-633.33Myoblast growth factor receptor egl-15 [Source:Un... [more]
egl-152.807e-633.33Myoblast growth factor receptor egl-15 [Source:Un... [more]
egl-152.807e-633.33Myoblast growth factor receptor egl-15 [Source:Un... [more]
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BLAST of Neuregulin 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pxn2.029e-1034.00gene:FBgn0011828 transcript:FBtr0072954[more]
Pxn2.029e-1034.00gene:FBgn0011828 transcript:FBtr0072951[more]
Pxn2.029e-1034.00gene:FBgn0011828 transcript:FBtr0072952[more]
Pxn2.029e-1034.00gene:FBgn0011828 transcript:FBtr0072953[more]
ihog1.448e-636.26gene:FBgn0031872 transcript:FBtr0079365[more]
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BLAST of Neuregulin 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nrg2b8.047e-1232.61neuregulin 2b [Source:ZFIN;Acc:ZDB-GENE-090205-2][more]
nrg2b1.965e-1132.61neuregulin 2b [Source:ZFIN;Acc:ZDB-GENE-090205-2][more]
nrg2b2.531e-1132.61neuregulin 2b [Source:ZFIN;Acc:ZDB-GENE-090205-2][more]
nrg2a5.027e-1029.22neuregulin 2a [Source:ZFIN;Acc:ZDB-GENE-070615-10][more]
nrg2a6.225e-1030.28neuregulin 2a [Source:ZFIN;Acc:ZDB-GENE-070615-10][more]
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BLAST of Neuregulin 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MYPN4.900e-1036.63myopalladin [Source:NCBI gene;Acc:100495211][more]
lsamp2.578e-823.66limbic system associated membrane protein [Source:... [more]
MYPN4.655e-831.82myopalladin [Source:NCBI gene;Acc:100495211][more]
MYPN5.234e-832.71myopalladin [Source:NCBI gene;Acc:100495211][more]
MYPN5.540e-832.71myopalladin [Source:NCBI gene;Acc:100495211][more]
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BLAST of Neuregulin 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Mypn2.642e-832.73myopalladin [Source:MGI Symbol;Acc:MGI:1916052][more]
Ttn3.068e-731.11titin [Source:MGI Symbol;Acc:MGI:98864][more]
Ttn3.121e-731.11titin [Source:MGI Symbol;Acc:MGI:98864][more]
Ttn5.369e-730.00titin [Source:MGI Symbol;Acc:MGI:98864][more]
Palld6.074e-731.76palladin, cytoskeletal associated protein [Source:... [more]
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BLAST of Neuregulin 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9VZZ4|PXDN_DROME2.034e-934.00Peroxidasin OS=Drosophila melanogaster OX=7227 GN=... [more]
sp|Q86TC9|MYPN_HUMAN1.726e-731.86Myopalladin OS=Homo sapiens OX=9606 GN=MYPN PE=1 S... [more]
sp|Q5DTJ9|MYPN_MOUSE1.848e-732.73Myopalladin OS=Mus musculus OX=10090 GN=Mypn PE=1 ... [more]
sp|B4KJW1|IHOG_DROMO3.448e-637.21Interference hedgehog OS=Drosophila mojavensis OX=... [more]
sp|B4HY03|IHOG_DROSE4.638e-636.26Interference hedgehog OS=Drosophila sechellia OX=7... [more]
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BLAST of Neuregulin 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3R7H6F91.121e-1331.03Uncharacterized protein OS=Clonorchis sinensis OX=... [more]
A0A267EJI31.106e-1234.38Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267H3A31.330e-1234.38Uncharacterized protein OS=Macrostomum lignano OX=... [more]
W5ULJ73.120e-1232.95Pro-neuregulin-1, membrane-bound isoform OS=Ictalu... [more]
A0A4S2M4L71.497e-1127.67Uncharacterized protein OS=Opisthorchis felineus O... [more]
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BLAST of Neuregulin 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nrg12.356e-1131.58neuregulin 1 [Source:NCBI gene;Acc:103034938][more]
ENSAMXT00000003826.22.367e-1135.58myopalladin [Source:NCBI gene;Acc:103025959][more]
nrg12.413e-1131.58neuregulin 1 [Source:NCBI gene;Acc:103034938][more]
nrg2b3.786e-1130.88pro-neuregulin-2, membrane-bound isoform-like [Sou... [more]
nrg2b4.183e-1130.88pro-neuregulin-2, membrane-bound isoform-like [Sou... [more]
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BLAST of Neuregulin 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ENSPMAT00000002502.15.876e-730.95pep scaffold:Pmarinus_7.0:GL476400:249000:366561:-... [more]
nfasca8.856e-734.78neurofascin homolog (chicken) a [Source:ZFIN;Acc:Z... [more]
ENSPMAT00000005837.12.571e-630.95pep scaffold:Pmarinus_7.0:GL476948:9490:27870:1 ge... [more]
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BLAST of Neuregulin 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Neuregulin 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO431717.265e-831.68Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO481798.955e-827.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO306254.170e-736.84Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO495584.106e-624.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO495534.548e-627.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Neuregulin 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nrg2b2.196e-931.43pro-neuregulin-2, membrane-bound isoform [Source:N... [more]
nrg2b2.281e-931.43pro-neuregulin-2, membrane-bound isoform [Source:N... [more]
MYPN1.579e-832.14myopalladin [Source:NCBI gene;Acc:101175503][more]
MYPN1.616e-832.14myopalladin [Source:NCBI gene;Acc:101175503][more]
MYPN1.620e-832.14myopalladin [Source:NCBI gene;Acc:101175503][more]
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BLAST of Neuregulin 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000026010.10.000e+0100.00SMESG000026010.1[more]
SMESG000026010.10.000e+099.52SMESG000026010.1[more]
SMESG000023969.13.988e-1226.57SMESG000023969.1[more]
SMESG000023969.13.992e-1226.57SMESG000023969.1[more]
SMESG000028939.11.129e-927.54SMESG000028939.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30017199 ID=SMED30017199|Name=Neuregulin 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1488bp
AATCTGCAATCTGATTGGTTGAAATTAAAGTGAAAAGAATGTGCAAATGT
AATGGTTGAGATATTTAGAATTTTGTTCTATTGAATTCGATATTGAATCT
ATTTCGTTTTTTTGGGTATATCGTGGAGAGTTTCTTTTTCCTCATCAAAA
TTGATCACTTCACTGTCAATGAGAAAATCGACAATCGATGCCCCTGTGCT
GATCAAGAGGCCAACGAATAACAATGAAATAACCCTTCAGGAAGGGAATT
TGTTGAAAATCAAATGCCAAGCTGATGGAAATCCAATTCCAAAAATCGAT
TGGTATTTAAATGGCACAAAAATCGATAAGAGCACTTATAAAGACATTCA
AATTGAAATAAAAGGAAATCTGTCAACACTTATCATTGGAAAGGTTGGAA
CGAGACACGAAGGAAACTTTTCCTGTATTGCGCATAATAATAATGGACTT
TTGAGTAAATGGGCCTATGTATCCGTTATGAAAAATTACACAATGGATAC
GACAATTCGAAGTTCAACTTCAGTTTATTTTTGTTCTCAAGAAACGTGCG
TTTACGGATCCTGCATTCGGGAAAACAACACCAGCTTTTGCAGGTGTTTA
CCTCCATATTCAGGTATTCGATGTGAATATCAGCCGCCTGAAAAGGTGAA
TTTTACCGAGCCCTGTATAACATTTCAGAATAATAAAGATCACTCGTTCA
CCGAGAACAAACTTTTCGCCTTGATCAGTTTCAGTCTTTTACTAGTTTTG
GTGTTATTATTAATTATACTATTGTGCTTTTATAAATTCAGAAAACGACG
GAGTTATATTCACGGAATTAAAGCCAAGAAATTGAAAAACGCAGCTACTC
AAGTGTCCGATATATTTTATTCCGATTTGAATATATCTCAAATTCCTGAT
AATATTTCAAGTTCAATTTTAAATACCGAAAAATCCTTTCTTAGCAGTTG
CGTTTACAATGAGGCACCACCGTACAACTCTCTAGTGATTCAGAAAGATT
CTCGCGGTCCCCCAAGTGGTCAGTCATGTTCCAGTCAAGATACGTCATTA
ACGAATACAGTAGTTATTCCCAAATCTATTCTCTTATCGGTTAATGACAA
TTCATATTCTCTATATAACTCCTCAACAATGAACAACAATTACTGCCATA
CTCAACTTCCACCTCAGATGATACGATTAGAAAACACGTCCCCGTATCTC
TGTCCGGCATTGGAAACGGAAACCAATCTCTCGCTGAACAATTACATTGG
GAATATTATTTCACTTCCTTTCTCATGTAATGATCCGTGTTGTTGTCTCA
ATGTCGACTCAAAAAATCTACTCACGCCAACTCTACAAAATAATGTTTCA
AAACCTTCACTCATATCTATTCATTCGAATCCGATGGAATCAGATCACAT
TTGTACGTGTAAATGTAATATTCAATCAATTAATACTTTTGTTTAAAATT
TTTTTTAAAAAAATTGTATTTTTTTATTTGTGAAAAAA
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protein sequence of SMED30017199-orf-1

>SMED30017199-orf-1 ID=SMED30017199-orf-1|Name=SMED30017199-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=426bp
MRKSTIDAPVLIKRPTNNNEITLQEGNLLKIKCQADGNPIPKIDWYLNGT
KIDKSTYKDIQIEIKGNLSTLIIGKVGTRHEGNFSCIAHNNNGLLSKWAY
VSVMKNYTMDTTIRSSTSVYFCSQETCVYGSCIRENNTSFCRCLPPYSGI
RCEYQPPEKVNFTEPCITFQNNKDHSFTENKLFALISFSLLLVLVLLLII
LLCFYKFRKRRSYIHGIKAKKLKNAATQVSDIFYSDLNISQIPDNISSSI
LNTEKSFLSSCVYNEAPPYNSLVIQKDSRGPPSGQSCSSQDTSLTNTVVI
PKSILLSVNDNSYSLYNSSTMNNNYCHTQLPPQMIRLENTSPYLCPALET
ETNLSLNNYIGNIISLPFSCNDPCCCLNVDSKNLLTPTLQNNVSKPSLIS
IHSNPMESDHICTCKCNIQSINTFV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005102signaling receptor binding
GO:0005515protein binding
GO:0004672protein kinase activity
GO:0004713protein tyrosine kinase activity
GO:0004872receptor activity
GO:0005524ATP binding
GO:0017147Wnt-protein binding
GO:0042803protein homodimerization activity
GO:0046982protein heterodimerization activity
GO:0050839cell adhesion molecule binding
GO:1904929coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR040180Neuregulin
IPR036179Ig-like_dom_sf
IPR003598Ig_sub2
IPR003599Ig_sub
IPR013783Ig-like_fold
IPR013032EGF-like_CS
IPR007110Ig-like_dom
IPR000742EGF-like_dom
Vocabulary: biological process
TermDefinition
GO:0001736establishment of planar polarity
GO:0006468protein phosphorylation
GO:0007155cell adhesion
GO:0007399nervous system development
GO:0007411axon guidance
GO:0016055Wnt signaling pathway
GO:0018108peptidyl-tyrosine phosphorylation
GO:0031290retinal ganglion cell axon guidance
GO:0035260internal genitalia morphogenesis
GO:0048803imaginal disc-derived male genitalia morphogenesis
GO:0048804imaginal disc-derived female genitalia morphogenesis
GO:0060026convergent extension
GO:0060071Wnt signaling pathway, planar cell polarity pathway
GO:0072499photoreceptor cell axon guidance
GO:0090090negative regulation of canonical Wnt signaling pathway
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0005887integral component of plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR003598Immunoglobulin subtype 2SMARTSM00408igc2_5coord: 30..99
e-value: 1.2E-9
score: 48.0
IPR003599Immunoglobulin subtypeSMARTSM00409IG_3ccoord: 24..110
e-value: 1.6E-4
score: 31.0
NoneNo IPR availablePFAMPF13927Ig_3coord: 23..96
e-value: 3.6E-13
score: 49.9
NoneNo IPR availablePANTHERPTHR11100:SF20PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM-RELATEDcoord: 27..221
NoneNo IPR availableCDDcd00096Igcoord: 35..99
e-value: 4.63859E-10
score: 53.4
NoneNo IPR availableSUPERFAMILYSSF57196EGF/Laminincoord: 123..161
NoneNo IPR availableTMHMMTMhelixcoord: 189..211
IPR013783Immunoglobulin-like foldGENE3DG3DSA:2.60.40.10coord: 3..103
e-value: 6.8E-18
score: 66.6
IPR040180NeuregulinPANTHERPTHR11100HEREGULIN-NEUREGULIN FAMILY MEMBERcoord: 27..221
IPR013032EGF-like, conserved sitePROSITEPS00022EGF_1coord: 147..158
IPR013032EGF-like, conserved sitePROSITEPS01186EGF_2coord: 147..158
IPR000742EGF-like domainPROSITEPS50026EGF_3coord: 124..159
score: 9.112
IPR007110Immunoglobulin-like domainPROSITEPS50835IG_LIKEcoord: 15..108
score: 12.441
IPR036179Immunoglobulin-like domain superfamilySUPERFAMILYSSF48726Immunoglobulincoord: 14..109