noggin 1

Overview


Name	noggin 1 (ABV04323.1)
Smed ID	SMED30017196
Length (bp)	1062

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of noggin 1 (SMED30017196) t-SNE clustered cells

Violin plots show distribution of expression levels for noggin 1 (SMED30017196) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of noggin 1 (SMED30017196) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for noggin 1 (SMED30017196) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30017196

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 17

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
prepharyngeal region	SMED30017196	h1SMcG0001496	dd_Smed_v6_15423_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
pharynx	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:21295483 Gaviño et al., 2011
dorsal ventral margin of the whole animal	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:21295483 Gaviño et al., 2011
cephalic ganglia	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:21295483 Gaviño et al., 2011
mouth	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:21295483 Gaviño et al., 2011
ventral nerve cord	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:21295483 Gaviño et al., 2011
pharynx	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:19174194 Molina et al., 2009
dorsal midline	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:19174194 Molina et al., 2009
dorsal ventral margin of the whole animal	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:19174194 Molina et al., 2009
cephalic ganglia	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:19174194 Molina et al., 2009
mouth	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:19174194 Molina et al., 2009
ventral nerve cord	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:19174194 Molina et al., 2009
pharynx	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:17905225 Molina et al., 2007
dorsal midline	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:17905225 Molina et al., 2007
dorsal ventral margin of the whole animal	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:17905225 Molina et al., 2007
mouth	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:17905225 Molina et al., 2007
central nervous system	SMED30017196	h1SMcG0001496	EF633690.1	smed_ncbi_20240424	PMID:17905225 Molina et al., 2007

Note: Hover over icons to view figure legend

Homology

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BLAST of noggin 1 vs. Ensembl Human
Match: NOG (noggin [Source:HGNC Symbol;Acc:HGNC:7866])

HSP 1 Score: 85.5001 bits (210), Expect = 1.023e-18
Identity = 58/186 (31.18%), Postives = 86/186 (46.24%), Query Frame = 2

Query:  299 FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPR-------------ESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            FD  EK  NE +LR     + +  F+    P              E L   +  ++  P S  M +  +   F   LA       K RL++K RR ++ ++ +  +CPV Y W D G RFWP +VK G C +   SCSVP GM C       + + R+ C +R  +  C W  +  PI++ C+CSC
Sbjct:   54 FDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRP-SGAMPSEIKGLEFSEGLA----QGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKR-SCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQ-RCGWIPIQYPIISECKCSC 232

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BLAST of noggin 1 vs. Ensembl Zebrafish
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 91.6633 bits (226), Expect = 2.421e-21
Identity = 57/187 (30.48%), Postives = 88/187 (47.06%), Query Frame = 2

Query:  266 GVEFPRLDEQP---FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            G+  P L E P    D  E+  +E+ L      N +++F+ I  P +        +  +P    +K  D           PYG  +K  + +K RR   Q++  + +CPV Y W D G+RFWP ++KEG+C +   SCS P GM C      T    R+ C     +  C W ++  PI++ C+CSC
Sbjct:   36 GLPVPDLIENPDPEHDPREQDLSEKTLLKKLGSNFDANFMSIHLPAQLNASAPPELPRLPMPAELKKLD-------LTETPYGRRVK--VGKKARRKFLQWLWMYTHCPVLYTWKDLGLRFWPRYIKEGNCFS-ERSCSFPEGMSCKPVKAVTKTFLRWYCQGFMRQKYCTWIQVQYPIISQCKCSC 212

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BLAST of noggin 1 vs. Ensembl Zebrafish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 85.1149 bits (209), Expect = 6.361e-19
Identity = 54/186 (29.03%), Postives = 88/186 (47.31%), Query Frame = 2

Query:  269 VEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDR---KWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            VE     +   D  E+  NE  LR     +   +F+ I  P +      G+ +     LM +  +    K I      + +G   KP  ++K RR ++ ++ ++ +CPV + W D G RFWP ++K G C N   SCSVP GM C       + + R+ C++R     C W  +  P+++ C+CSC
Sbjct:   42 VELKEDPDPVLDPKERDLNETELRAILGSHFEQNFMSINPPEDKH---AGQDELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKP--SKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKR-SCSVPEGMVCKPAKSSHLTVLRWRCVQRKGGLKCAWIPVQYPVISECKCSC 221

[Close]

BLAST of noggin 1 vs. Ensembl Zebrafish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 85.1149 bits (209), Expect = 6.958e-19
Identity = 54/186 (29.03%), Postives = 88/186 (47.31%), Query Frame = 2

Query:  269 VEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDR---KWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            VE     +   D  E+  NE  LR     +   +F+ I  P +      G+ +     LM +  +    K I      + +G   KP  ++K RR ++ ++ ++ +CPV + W D G RFWP ++K G C N   SCSVP GM C       + + R+ C++R     C W  +  P+++ C+CSC
Sbjct:   42 VELKEDPDPVLDPKERDLNETELRAILGSHFEQNFMSINPPEDKHA---GQDELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKP--SKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKR-SCSVPEGMVCKPAKSSHLTVLRWRCVQRKGGLKCAWIPVQYPVISECKCSC 221

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Query:  269 VEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDR---KWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            VE     +   D  E+  NE  LR     +   +F+ I  P +      G+ +     LM +  +    K I      + +G   KP  ++K RR ++ ++ ++ +CPV + W D G RFWP ++K G C N   SCSVP GM C       + + R+ C++R     C W  +  P+++ C+CSC
Sbjct:   42 VELKEDPDPVLDPKERDLNETELRAILGSHFEQNFMSINPPEDKHA---GQDELNESELMKQRPNGIMPKEIKAMEFDIQHGKKHKP--SKKLRRRLQLWLWSYTFCPVVHTWQDLGNRFWPRYLKVGSCYNKR-SCSVPEGMVCKPAKSSHLTVLRWRCVQRKGGLKCAWIPVQYPVISECKCSC 221

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BLAST of noggin 1 vs. Ensembl Zebrafish
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 82.0333 bits (201), Expect = 6.819e-18
Identity = 55/174 (31.61%), Postives = 85/174 (48.85%), Query Frame = 2

Query:  299 FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSCG 820
            +D  EK  NE  LR   L + +S FL +  P++     N  +      L +     K I +     P+G   K   ++K +R ++ ++ ++++CPV Y W D G RFWP +V+ G C     SCSVP GM C       + + R+ C+ R     C W  +  PI+T C+CSC 
Sbjct:   47 YDPREKDLNETELRS-ALGDFDSRFLSVGPPQDRYAG-NEDLDEQELQLNLAGMMPKDIKNLDFDAPWGKKRK--ASKKLKRRLQMWLWSYSFCPVLYAWNDLGSRFWPRFVRAGSCYTKR-SCSVPEGMVCKPAKSTHITLLRWRCVARRGALKCAWIPVQYPIITECKCSCA 215

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BLAST of noggin 1 vs. Ensembl Xenopus
Match: acad10 (acyl-CoA dehydrogenase family member 10 [Source:Xenbase;Acc:XB-GENE-967980])

HSP 1 Score: 95.9005 bits (237), Expect = 9.907e-23
Identity = 64/188 (34.04%), Postives = 95/188 (50.53%), Query Frame = 2

Query:  269 VEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLM-MKTSDRKWIFDRFLAL---PYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDN-CKWYKMHIPILTSCRCSC 817
            +E P  ++ P    E+  +E  LR     N + +F+       S++ PN    +   SL  MKT     +  + L L   PYG  +  R+ +K RR   Q++  + YCPV Y W D G+RFWP ++KEGHC +   SCS P GM+C      T    R+ C + WT+   C W  +  PI++ C+CSC
Sbjct:   45 IEHPDPEQDP---KEQDLDERTLRKKLGSNFDPNFM-------SVVLPNSVNMSTQDSLTKMKTLGSVPLELKKLDLSETPYGGRI--RMGKKARRKFLQWLWAYTYCPVMYTWKDLGVRFWPRFIKEGHCFS-EKSCSFPEGMYCKPIKSVTKTFLRWYC-QGWTRQRYCTWIPVQYPIISECKCSC 218

[Close]

BLAST of noggin 1 vs. Ensembl Xenopus
Match: nog (noggin [Source:NCBI gene;Acc:493191])

HSP 1 Score: 92.4337 bits (228), Expect = 2.237e-21
Identity = 56/176 (31.82%), Postives = 87/176 (49.43%), Query Frame = 2

Query:  299 FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNL---KPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            +D  EK  NE +LR   + + + +F+ I  P E L    G        L+++      +      L +   L   K RL++K RR ++ ++ +  +CPV Y W D G RFWP +VK G C +   SCSVP GM C       + I R+ C +R  +  C W  +  P+++ C+CSC
Sbjct:   53 YDPKEKDLNETLLRTLMVGHFDPNFMAINLPEERL----GVEDLGELDLLLRQKPSGAMPAEIKGLEFYEGLQGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYSKR-SCSVPEGMVCKAAKSMHLTILRWRCQRR-VQQKCAWITIQYPVISECKCSC 222

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BLAST of noggin 1 vs. Ensembl Xenopus
Match: nog4 (noggin 4 [Source:NCBI gene;Acc:733455])

HSP 1 Score: 70.0922 bits (170), Expect = 2.594e-13
Identity = 35/128 (27.34%), Postives = 57/128 (44.53%), Query Frame = 2

Query:  464 RKWIFDRFLALPYGNNLKPRLTQKKRRL-----IRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKR-----WTKDNCKWYKMHIPILTSCRCSC 817
            RK +     AL +G+   PR       L     IRQ++     C +   W+D G  FWP WV+   C   + +CS P GM C +     + +  + C  +     W    C W ++  P++ +C+C+C
Sbjct:  118 RKKLAQEAQALDFGSLQLPRELSANSSLHVQNEIRQWLVQRASCQLTSTWVDLGTVFWPRWVRHTDCDGANTACSWPPGMACRQAQLTQIKLLAWHCWMKDTGLGWATQQCTWRQVPYPVVAACKCTC 245

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BLAST of noggin 1 vs. Ensembl Mouse
Match: Nog (noggin [Source:MGI Symbol;Acc:MGI:104327])

HSP 1 Score: 85.5001 bits (210), Expect = 6.485e-19
Identity = 58/186 (31.18%), Postives = 86/186 (46.24%), Query Frame = 2

Query:  299 FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPR-------------ESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            FD  EK  NE +LR     + +  F+    P              E L   +  ++  P S  M +  +   F   LA       K RL++K RR ++ ++ +  +CPV Y W D G RFWP +VK G C +   SCSVP GM C       + + R+ C +R  +  C W  +  PI++ C+CSC
Sbjct:   54 FDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGPAGGAEDLAELDQLLRQRP-SGAMPSEIKGLEFSEGLA----QGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKR-SCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQ-RCGWIPIQYPIISECKCSC 232

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BLAST of noggin 1 vs. UniProt/SwissProt
Match: sp|P49011|NOGG_XENLA (Noggin OS=Xenopus laevis OX=8355 GN=nog PE=1 SV=1)

HSP 1 Score: 92.0485 bits (227), Expect = 1.480e-20
Identity = 55/176 (31.25%), Postives = 86/176 (48.86%), Query Frame = 2

Query:  299 FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNL---KPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            +D  EK  NE +LR   + + + +F+    P E L    G        L+++      +      L +   L   K RL++K RR ++ ++ +  +CPV Y W D G RFWP +VK G C +   SCSVP GM C       + I R+ C +R  +  C W  +  P+++ C+CSC
Sbjct:   53 YDPKEKDLNETLLRTLMVGHFDPNFMATILPEERL----GVEDLGELDLLLRQKPSGAMPAEIKGLEFYEGLQSKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGTRFWPRYVKVGSCYS-KRSCSVPEGMVCKAAKSMHLTILRWRCQRR-VQQKCAWITIQYPVISECKCSC 222

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BLAST of noggin 1 vs. UniProt/SwissProt
Match: sp|Q9W740|NOGG2_DANRE (Noggin-2 OS=Danio rerio OX=7955 GN=nog2 PE=2 SV=1)

HSP 1 Score: 91.6633 bits (226), Expect = 1.828e-20
Identity = 57/187 (30.48%), Postives = 88/187 (47.06%), Query Frame = 2

Query:  266 GVEFPRLDEQP---FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            G+  P L E P    D  E+  +E+ L      N +++F+ I  P +        +  +P    +K  D           PYG  +K  + +K RR   Q++  + +CPV Y W D G+RFWP ++KEG+C +   SCS P GM C      T    R+ C     +  C W ++  PI++ C+CSC
Sbjct:   36 GLPVPDLIENPDPEHDPREQDLSEKTLLKKLGSNFDANFMSIHLPAQLNASAPPELPRLPMPAELKKLD-------LTETPYGRRVK--VGKKARRKFLQWLWMYTHCPVLYTWKDLGLRFWPRYIKEGNCFS-ERSCSFPEGMSCKPVKAVTKTFLRWYCQGFMRQKYCTWIQVQYPIISQCKCSC 212

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BLAST of noggin 1 vs. UniProt/SwissProt
Match: sp|O93525|NOGG_CHICK (Noggin OS=Gallus gallus OX=9031 GN=NOG PE=2 SV=1)

HSP 1 Score: 89.3521 bits (220), Expect = 1.801e-19
Identity = 56/177 (31.64%), Postives = 86/177 (48.59%), Query Frame = 2

Query:  299 FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKP----RLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            FD  EK  NE +LR     + + +F+ +  P + L    G        L+++      +      L + + L+P    RL++K RR ++ ++ +  +CPV Y W D G RFWP +VK G C +   SCSVP GM C       + I R+ C +R     C W  +  PI+  C+CSC
Sbjct:   53 FDPKEKDLNETLLRSLMGGHFDPNFMAMSLPEDRL----GVDDLAELDLLLRQRPSGAMPGEIKGLEFYDGLQPGKKHRLSKKLRRKLQMWLWSQTFCPVLYTWNDLGSRFWPRYVKVGSCYSKR-SCSVPEGMVCKPAKSVHLTILRWRCQRR-GGQRCTWIPIQYPIIAECKCSC 223

[Close]

BLAST of noggin 1 vs. UniProt/SwissProt
Match: sp|Q9YHT8|NOGG_TAKRU (Noggin OS=Takifugu rubripes OX=31033 GN=nog PE=3 SV=1)

HSP 1 Score: 86.6557 bits (213), Expect = 1.683e-18
Identity = 54/173 (31.21%), Postives = 84/173 (48.55%), Query Frame = 2

Query:  299 FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            FD  E+  NE  L+   L + +S FL +  P E     N  +             ++     F A   G   KP    K+R  ++Q++  +++CP+ + W D G RFWP +V+ G C++   SCSVP GM C   +   + I R+ C++R     C W  M  P++T C+CSC
Sbjct:   53 FDPKERDLNETELKSV-LGDFDSRFLSVLPPAEDGHAGNDELDDFDAQRWGGALPKEIRAVDFDAPQLGKKHKPSKKLKRR--LQQWLWAYSFCPLAHAWTDLGSRFWPRFVRAGSCLSKR-SCSVPEGMTCKPATSTHLTILRWRCVQRKVGLKCAWIPMQYPVITDCKCSC 221

[Close]

BLAST of noggin 1 vs. UniProt/SwissProt
Match: sp|P97466|NOGG_MOUSE (Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 4.536e-18
Identity = 58/186 (31.18%), Postives = 86/186 (46.24%), Query Frame = 2

Query:  299 FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPR-------------ESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            FD  EK  NE +LR     + +  F+    P              E L   +  ++  P S  M +  +   F   LA       K RL++K RR ++ ++ +  +CPV Y W D G RFWP +VK G C +   SCSVP GM C       + + R+ C +R  +  C W  +  PI++ C+CSC
Sbjct:   54 FDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGPAGGAEDLAELDQLLRQRP-SGAMPSEIKGLEFSEGLA----QGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKR-SCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQ-RCGWIPIQYPIISECKCSC 232

[Close]

BLAST of noggin 1 vs. TrEMBL
Match: A8SLH4 (Noggin 1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 525.398 bits (1352), Expect = 0.000e+0
Identity = 254/255 (99.61%), Postives = 254/255 (99.61%), Query Frame = 2

Query:   56 MKDFEVIFLLSILVILTQTLPKSGSEIISENLWKSFQMKNENNKQKTPKENQSNFYNISKDISIVQSAILGVEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSCG 820
            MKDFEVIFLLSILVILTQTLPKSGSEIISENLWKSFQMKNENNKQKTPKENQSNFYNISKDISIVQSAILGVEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRL QKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSCG
Sbjct:    1 MKDFEVIFLLSILVILTQTLPKSGSEIISENLWKSFQMKNENNKQKTPKENQSNFYNISKDISIVQSAILGVEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLNQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSCG 255

[Close]

BLAST of noggin 1 vs. TrEMBL
Match: C1JAC1 (Noggin 2 OS=Schmidtea mediterranea OX=79327 GN=nog2 PE=2 SV=1)

HSP 1 Score: 134.42 bits (337), Expect = 2.254e-33
Identity = 72/255 (28.24%), Postives = 130/255 (50.98%), Query Frame = 2

Query:   71 VIFLLSILVILTQTLPKSGSEIISENLWKSFQMKNENNKQKTPKENQSNFYNISKDISIVQ----SAILGVEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSL-MMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSCG 820
            V  ++  L I+   +  +  + +S++LW  FQ +N    +   ++     Y+ +   S+++                E+      K  N ++L++   +N NS+F+ I +P  S    + +   +  SL +++  ++K    + L L +    +  + +  RR +R F+  F++CPV Y+W D G +FWP W+K+G C N+  SCS P G+ C E  HK + + R++C+  W  D CKWYK++IP L +CRC C 
Sbjct:   10 VYVVILFLGIIAAQISLNDRDNVSQSLWVQFQKRNVAKYRDQTEKKPFASYSRNSLESLLKPNYKPKFPFFFPNFKTEEIARAAFKLTNGQLLKLLNRKNFNSNFMSITEPESS---NDIKQFYISKSLNLIEKQNQKSFLRKALQLFHLKKFRKTINRDFRRKLRTFLDLFSWCPVTYQWKDMGPKFWPRWIKQGSCANLSKSCSYPEGLVCQEYEHKNIAVLRFLCMSDWAIDKCKWYKIYIPFLLTCRCGCN 261

[Close]

BLAST of noggin 1 vs. TrEMBL
Match: A0A183QG47 (Uncharacterized protein OS=Schistosoma rodhaini OX=6188 PE=4 SV=1)

HSP 1 Score: 129.798 bits (325), Expect = 3.312e-31
Identity = 81/294 (27.55%), Postives = 142/294 (48.30%), Query Frame = 2

Query:   95 VILTQTLPKSGSEIISENLWKSFQMKNENNKQKTPKENQSNFYNISKDISIVQ-SAILGVEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRI-----------QTVPYSLMMKTSDRKW----------IFDRFLA----------------------------LPYGNNLKPRLTQKK--RRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNI-HGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            V+L+     + ++ ++EN+ +  +    +++     E  S    ++K   I Q + I        +E+PF  +      EM+R+    N N++F+   +P E++++P GR+           +T+  SL      RK           I+DR+                              L Y N+L  R+ + +  RR++R+F+ ++N CP++Y W D G +FWP W+K   CVN+ + SCS+P GM+CHE + + + I RYIC ++W    C WY++H+PI+T C C C
Sbjct:    5 VLLSLGNLTTVNDHLNENMGRKLKNDRHHHQGHLKTEVNSKLRTLNKLFQISQLTIIPHQIPIIPNERPFHDHVLLNYNEMIRLLGGHNFNNEFMSFNKPWEAIMYPRGRLISFTKYDRNNLETIT-SLNRNRRSRKIKPQKQQQLINIYDRYKKKKKKQNHLDPSSSNLFQNVMDRLKLIQNLKYKNHLHNRMKKNRQLRRILREFLNDYNNCPLYYIWYDLGPKFWPRWIKTSQCVNLANTSCSLPPGMYCHEKNIENIAILRYICPEKWPLSKCNWYRVHLPIVTECSCQC 297

[Close]

BLAST of noggin 1 vs. TrEMBL
Match: A0A5J4NUH6 (Noggin OS=Paragonimus westermani OX=34504 GN=DEA37_0007963 PE=4 SV=1)

HSP 1 Score: 129.028 bits (323), Expect = 1.429e-30
Identity = 49/100 (49.00%), Postives = 72/100 (72.00%), Query Frame = 2

Query:  521 RLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHG-SCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            R  QK RR +R+ +T ++ CPV Y W D+G ++WP WVK+G C N+ G SCS+P GM+CHE ++  +++ RY+CL+ W   +C WY+MH+P+LT CRC C
Sbjct:  237 RFRQKLRRTLRRLITEYSNCPVHYIWKDQGAKYWPRWVKQGQCTNLKGKSCSIPPGMYCHEANYINLVVLRYLCLEDWPLTSCNWYRMHMPVLTQCRCGC 336

[Close]

BLAST of noggin 1 vs. TrEMBL
Match: A0A5K4FG94 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 125.946 bits (315), Expect = 2.239e-30
Identity = 70/229 (30.57%), Postives = 116/229 (50.66%), Query Frame = 2

Query:  287 DEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRI-----------QTVPYSLMMKTSDRKW----------IFDRF----------------------------LALPYGNNLKPRLTQKK--RRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNI-HGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            +E+PF  +      EM+ +    N N++F+   +P E++++P GR+           +T+  SL      RK           I+DR+                              L Y ++L  R+ + +  RR++R+F+ ++N CP++Y W D G +FWP W+K G CVN+ + SCS+P GM+CHE + + + I RYIC ++W    C WY++H+PI+T C C C
Sbjct:   16 NERPFRDHVLLNYNEMIHLLGGHNFNNEFMSFHKPWEAIMYPRGRLISFTKYDRNTLETIT-SLNRNRRSRKIKLQKQQQLINIYDRYNKKKRKQNHVDPSSNNLFQNVMNRLKLIQNLKYEDHLHNRMKKNRQLRRILREFLNDYNNCPLYYIWYDLGPKFWPRWIKTGQCVNLANTSCSLPPGMYCHEKNIENIAILRYICPEKWPLSKCNWYRVHLPIVTECSCQC 243

[Close]

BLAST of noggin 1 vs. Ensembl Cavefish
Match: ENSAMXT00000051007.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000650.1:142689:143405:-1 gene:ENSAMXG00000039724.1 transcript:ENSAMXT00000051007.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 82.4185 bits (202), Expect = 3.810e-18
Identity = 38/90 (42.22%), Postives = 51/90 (56.67%), Query Frame = 2

Query:  548 IRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            +R+F      CPV   W D G RFWP +V+ G C     SCSVP+GM C   +   V + R+ C +R T   C W ++H PI+T C+CSC
Sbjct:  119 LREFERERALCPVVQTWSDLGARFWPRYVRMGSCSR-ERSCSVPAGMLCTPAASTHVTLLRWRCARRGTL-RCAWIRVHYPIITECKCSC 206

[Close]

BLAST of noggin 1 vs. Ensembl Cavefish
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 79.7221 bits (195), Expect = 3.069e-17
Identity = 35/98 (35.71%), Postives = 56/98 (57.14%), Query Frame = 2

Query:  527 TQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKD-NCKWYKMHIPILTSCRCSC 817
            ++K RR ++ ++ ++ +CPV Y W D G RFWP +VK G C +   SCSVP GM C       + + R+ C+ R      C W  +  P+++ C+C+C
Sbjct:  103 SKKMRRRLQLWLWSYTFCPVVYAWQDLGSRFWPRYVKVGSCASKR-SCSVPEGMVCSPAKSAHLTLLRWYCIPRKAGGLRCLWIPVQYPVISECKCAC 199

[Close]

BLAST of noggin 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011420.1 (pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gene:ENSPMAG00000010393.1 transcript:ENSPMAT00000011420.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 90.5077 bits (223), Expect = 1.968e-21
Identity = 41/98 (41.84%), Postives = 55/98 (56.12%), Query Frame = 2

Query:  524 LTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            L +K RR ++ F+  +  CPV Y W D G RFWP +V+EG C +   SCS+P+GM C      +  I R+ C       NC W K+  PI+  CRCSC
Sbjct:  139 LGRKARRKMQLFLWAYTQCPVAYAWKDLGGRFWPRYVREGSCQSGR-SCSIPAGMSCKAQRSTSKAILRWYCRGWGAHRNCTWLKIQYPIIAECRCSC 235

[Close]

BLAST of noggin 1 vs. Ensembl Sea Lamprey
Match: nog3 (noggin 3 [Source:NCBI gene;Acc:30173])

HSP 1 Score: 88.9669 bits (219), Expect = 4.862e-21
Identity = 57/182 (31.32%), Postives = 90/182 (49.45%), Query Frame = 2

Query:  278 PRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRF--LALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            P LD +  DL+EK     +LR     + + +F+ +  P+      +G+ QT    L+  +        R     LP+G  +K  + ++ RR I Q++ ++ +CPV Y W D G RFWP +VKEG C N   SCS P GM C      +  + R+ C     +  C W  +  P+++ CRC+C
Sbjct:   52 PELDPKEQDLDEK-----LLRRKLGASFDPEFMAVSLPKGDA---SGQ-QTRGGRLLKPSGSMPNEIKRLDLGVLPHGQKIK--IGKRARRKILQWLWSYTFCPVLYTWKDLGERFWPRFVKEGSCYNGR-SCSFPEGMACKPFKSASKTLLRWHCQGWGRQKYCAWIHIQYPVISECRCAC 221

[Close]

BLAST of noggin 1 vs. Ensembl Sea Lamprey
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 78.9518 bits (193), Expect = 2.285e-17
Identity = 40/106 (37.74%), Postives = 54/106 (50.94%), Query Frame = 2

Query:  500 YGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            YG  LK  L ++ RR   Q++     CPV Y W +  +RFWP ++KEG C +   SCSVP GM C           R+ C     +  C W  +  P+LT C+CSC
Sbjct:  130 YGQKLK--LGKRARRKFLQWLWAHTACPVVYSWKELNVRFWPRYIKEGSCYSAR-SCSVPEGMVCKPVKFSNKTFLRWHCQGWGRQRFCTWIPIQYPVLTECKCSC 232

[Close]

BLAST of noggin 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009391.1 (pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-1 gene:ENSPMAG00000008500.1 transcript:ENSPMAT00000009391.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.1586 bits (152), Expect = 4.603e-12
Identity = 29/82 (35.37%), Postives = 39/82 (47.56%), Query Frame = 2

Query:  578 CPVFYKWIDKGIRFWPPWVKEGHCV-NIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSCG 820
            C V   W D G  FWP WV+  HC  +  G CS P+GM C       + I  + C    +   C W  +  P++T+C C CG
Sbjct:  117 CGVASSWHDLGSVFWPRWVRRSHCEESGGGGCSWPAGMSCAPAQSTHIKILAWHCYALRSASKCSWRLVPYPLVTACTCGCG 198

[Close]

BLAST of noggin 1 vs. Ensembl Nematostella
Match: EDO36952 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH36])

HSP 1 Score: 64.3142 bits (155), Expect = 4.931e-13
Identity = 33/105 (31.43%), Postives = 52/105 (49.52%), Query Frame = 2

Query:  503 GNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            G NL P+ ++K    ++ ++   + CPV+ KW D+G   WP +   G C     +CS P GM C     K V + R+ C  +     C+W K  + ++T C C C
Sbjct:   17 GRNLGPKASRK----LQLWLWELSSCPVYQKWKDQGQLIWPRYRNIGRCSR-KSTCSYPGGMKCKRSKTKRVALLRWFCRGK----LCQWLKFFVSVITECSCQC 112

[Close]

BLAST of noggin 1 vs. Ensembl Nematostella
Match: EDO36981 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH37])

HSP 1 Score: 48.1358 bits (113), Expect = 2.862e-7
Identity = 30/114 (26.32%), Postives = 47/114 (41.23%), Query Frame = 2

Query:  524 LTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLK----------------RWTKDNCKWYKMHIPILTSCRCSC 817
            L+++  R +  ++     CPV Y W D G  FWP +VK   C +    CS+     C   + +   I R+ C+                 R +   C W + + PI T C C+C
Sbjct:    1 LSREMERFMMGWLLQRENCPVVYSWRDMGPHFWPRFVKRATCKS--KQCSIDPSTQCEPSNSRYFNILRWHCMDDKAIQLLPLWGRHRAVRRSGHWCSWLRFYHPITTECSCAC 112

[Close]

BLAST of noggin 1 vs. Ensembl Medaka
Match: nog2 (noggin 2 [Source:NCBI gene;Acc:30185])

HSP 1 Score: 87.0409 bits (214), Expect = 1.018e-19
Identity = 58/186 (31.18%), Postives = 87/186 (46.77%), Query Frame = 2

Query:  278 PRLDEQP---FDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNG---RIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSC 817
            P L E P   +D  E+   E  LR     N + +F+ I  P +  L  +    ++Q  P    +K  D           PYG  +K  + +K RR   Q++  + +CPV Y W D G+RFWP ++KEG C +   SCS P GM C        +  R+ C     +  C W ++  PI++ C+CSC
Sbjct:   41 PDLREDPDPEYDPREQDLAERTLRKKLGSNFDPNFMSISSPLQVNLSASDYQVKLQG-PMPNEIKKLD-------LTETPYGKRVK--VGKKARRKFLQWLWTYTHCPVVYTWKDLGVRFWPRYIKEGKCFS-ERSCSFPEGMSCKPAKSINKIFLRWYCQGFLRQKYCTWIQVQYPIISECKCSC 215

[Close]

BLAST of noggin 1 vs. Ensembl Medaka
Match: nog1 (noggin 1 [Source:NCBI gene;Acc:30174])

HSP 1 Score: 82.0333 bits (201), Expect = 8.101e-18
Identity = 36/95 (37.89%), Postives = 56/95 (58.95%), Query Frame = 2

Query:  542 RLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKD--NCKWYKMHIPILTSCRCSCG 820
            R ++Q++  +++CPV Y W D G RFWP +V+ G C++   SCSVP GM C   S   +   R+ C++R   +   C W  +  P++T C+CSC 
Sbjct:  135 RRLQQWLWAYSFCPVLYSWTDLGNRFWPRFVRVGSCLS-KRSCSVPEGMVCKPASSTHLTTLRWRCVQRKAAERLKCAWIPVQYPVITDCKCSCS 228

[Close]

BLAST of noggin 1 vs. Planmine SMEST
Match: SMESG000032158.1 (SMESG000032158.1)

HSP 1 Score: 525.398 bits (1352), Expect = 0.000e+0
Identity = 254/255 (99.61%), Postives = 254/255 (99.61%), Query Frame = 2

Query:   56 MKDFEVIFLLSILVILTQTLPKSGSEIISENLWKSFQMKNENNKQKTPKENQSNFYNISKDISIVQSAILGVEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSCG 820
            MKDFEVIFLLSILVILTQTLPKSGSEIISENLWKSFQMKNENNKQKTPKENQSNFYNISKDISIVQSAILGVEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRL QKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSCG
Sbjct:    1 MKDFEVIFLLSILVILTQTLPKSGSEIISENLWKSFQMKNENNKQKTPKENQSNFYNISKDISIVQSAILGVEFPRLDEQPFDLNEKPPNEEMLRIFRLENLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYGNNLKPRLNQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCRCSCG 255

[Close]

BLAST of noggin 1 vs. Planmine SMEST
Match: SMESG000016086.1 (SMESG000016086.1)

HSP 1 Score: 62.7734 bits (151), Expect = 7.266e-11
Identity = 25/67 (37.31%), Postives = 40/67 (59.70%), Query Frame = 2

Query:  545 LIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLK 745
            L R+++  ++ C + + W D G  FWP W++ G C +   SCS PSGM C     +T+ + R++CLK
Sbjct:  159 LFRKWLIEYSSCQMNFVWEDLGEMFWPSWIRRGLCTS-SKSCSWPSGMACKHSGSRTLHLLRWVCLK 224

[Close]

BLAST of noggin 1 vs. Planmine SMEST
Match: SMESG000007613.1 (SMESG000007613.1)

HSP 1 Score: 57.3806 bits (137), Expect = 3.950e-9
Identity = 35/107 (32.71%), Postives = 56/107 (52.34%), Query Frame = 2

Query:  488 LALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSCR 808
            + L   N  K  +++     I+Q++   + C V Y W +    +WP WVK+G CVNI  SCS P GM C  +S++ + + ++IC +   K+  K  K+ I I    R
Sbjct:  100 ITLIDKNGFKINISKTILTSIQQWLIEESKCQVEYHWQELNETYWPRWVKKGLCVNI-KSCSWPPGMNCSPNSYRKLSLLQWICAEDKRKEKYKDDKLLIKIARKIR 205

[Close]

BLAST of noggin 1 vs. Planmine SMEST
Match: SMESG000034700.1 (SMESG000034700.1)

HSP 1 Score: 55.8398 bits (133), Expect = 6.801e-9
Identity = 29/84 (34.52%), Postives = 47/84 (55.95%), Query Frame = 2

Query:  488 LALPYGNNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVNIHGSCSVPSGMFCHEDSHKTVMIFRYIC 739
            + L   N  K  +++     I+Q++   + C V Y W +    +WP WVK+G CVNI  SCS P GM C  +S++ + + ++IC
Sbjct:  100 ITLIDKNGFKINISKTILTSIQQWLIEESKCQVEYHWQELNETYWPRWVKKGLCVNI-KSCSWPPGMNCSPNSYRKLSLLQWIC 182

[Close]

BLAST of noggin 1 vs. Planmine SMEST
Match: SMESG000008387.1 (SMESG000008387.1)

HSP 1 Score: 52.7582 bits (125), Expect = 1.668e-7
Identity = 24/67 (35.82%), Postives = 34/67 (50.75%), Query Frame = 2

Query:  542 RLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCV-NIHGSCSVPSGMFCHEDSHKTVMIFRYIC 739
            R+ R ++     C + Y W D G  FWP W++ G CV N+  SCS P GM C     + + I  + C
Sbjct:  160 RMFRNWLLKKATCVMDYIWEDLGPLFWPQWIRRGICVNNLAQSCSWPPGMKCRASGSRALHILYWAC 226

The following BLAST results are available for this feature:

BLAST of noggin 1 vs. Ensembl Human
BLAST of noggin 1 vs. Ensembl Celegans
BLAST of noggin 1 vs. Ensembl Fly
BLAST of noggin 1 vs. Ensembl Zebrafish
BLAST of noggin 1 vs. Ensembl Xenopus
BLAST of noggin 1 vs. Ensembl Mouse
BLAST of noggin 1 vs. UniProt/SwissProt
BLAST of noggin 1 vs. TrEMBL
BLAST of noggin 1 vs. Ensembl Cavefish
BLAST of noggin 1 vs. Ensembl Sea Lamprey
BLAST of noggin 1 vs. Ensembl Yeast
BLAST of noggin 1 vs. Ensembl Nematostella
BLAST of noggin 1 vs. Ensembl Medaka
BLAST of noggin 1 vs. Planmine SMEST

BLAST of noggin 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
NOG	1.023e-18	31.18	noggin [Source:HGNC Symbol;Acc:HGNC:7866]	[more]

BLAST of noggin 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nog2	2.421e-21	30.48	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
nog3	6.361e-19	29.03	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	6.958e-19	29.03	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog3	6.958e-19	29.03	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog1	6.819e-18	31.61	noggin 1 [Source:NCBI gene;Acc:30174]	[more]

BLAST of noggin 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
acad10	9.907e-23	34.04	acyl-CoA dehydrogenase family member 10 [Source:Xe...	[more]
nog	2.237e-21	31.82	noggin [Source:NCBI gene;Acc:493191]	[more]
nog4	2.594e-13	27.34	noggin 4 [Source:NCBI gene;Acc:733455]	[more]

BLAST of noggin 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Nog	6.485e-19	31.18	noggin [Source:MGI Symbol;Acc:MGI:104327]	[more]

BLAST of noggin 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P49011\|NOGG_XENLA	1.480e-20	31.25	Noggin OS=Xenopus laevis OX=8355 GN=nog PE=1 SV=1	[more]
sp\|Q9W740\|NOGG2_DANRE	1.828e-20	30.48	Noggin-2 OS=Danio rerio OX=7955 GN=nog2 PE=2 SV=1	[more]
sp\|O93525\|NOGG_CHICK	1.801e-19	31.64	Noggin OS=Gallus gallus OX=9031 GN=NOG PE=2 SV=1	[more]
sp\|Q9YHT8\|NOGG_TAKRU	1.683e-18	31.21	Noggin OS=Takifugu rubripes OX=31033 GN=nog PE=3 S...	[more]
sp\|P97466\|NOGG_MOUSE	4.536e-18	31.18	Noggin OS=Mus musculus OX=10090 GN=Nog PE=2 SV=1	[more]

BLAST of noggin 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A8SLH4	0.000e+0	99.61	Noggin 1 OS=Schmidtea mediterranea OX=79327 PE=2 S...	[more]
C1JAC1	2.254e-33	28.24	Noggin 2 OS=Schmidtea mediterranea OX=79327 GN=nog...	[more]
A0A183QG47	3.312e-31	27.55	Uncharacterized protein OS=Schistosoma rodhaini OX...	[more]
A0A5J4NUH6	1.429e-30	49.00	Noggin OS=Paragonimus westermani OX=34504 GN=DEA37...	[more]
A0A5K4FG94	2.239e-30	30.57	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]

BLAST of noggin 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSAMXT00000051007.1	3.810e-18	42.22	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
nog3	3.069e-17	35.71	noggin 3 [Source:NCBI gene;Acc:30173]	[more]

BLAST of noggin 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSPMAT00000011420.1	1.968e-21	41.84	pep scaffold:Pmarinus_7.0:GL487123:1955:2662:1 gen...	[more]
nog3	4.862e-21	31.32	noggin 3 [Source:NCBI gene;Acc:30173]	[more]
nog2	2.285e-17	37.74	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
ENSPMAT00000009391.1	4.603e-12	35.37	pep scaffold:Pmarinus_7.0:GL476782:173121:173762:-...	[more]

BLAST of noggin 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of noggin 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO36952	4.931e-13	31.43	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36981	2.862e-7	26.32	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of noggin 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nog2	1.018e-19	31.18	noggin 2 [Source:NCBI gene;Acc:30185]	[more]
nog1	8.101e-18	37.89	noggin 1 [Source:NCBI gene;Acc:30174]	[more]

BLAST of noggin 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000032158.1	0.000e+0	99.61	SMESG000032158.1	[more]
SMESG000016086.1	7.266e-11	37.31	SMESG000016086.1	[more]
SMESG000007613.1	3.950e-9	32.71	SMESG000007613.1	[more]
SMESG000034700.1	6.801e-9	34.52	SMESG000034700.1	[more]
SMESG000008387.1	1.668e-7	35.82	SMESG000008387.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30017196
GenBank	ABV04323.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30017196 ID=SMED30017196|Name=noggin 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1062bp
ATATAAATCTTATATGAAAACAATTGAAAAATCAATATACACTTGAAAAC
AACAAATGAAAGATTTCGAGGTGATTTTCCTATTATCGATATTAGTGATT
TTAACTCAAACTCTTCCGAAATCCGGTTCAGAAATCATATCGGAAAACCT
CTGGAAATCGTTCCAGATGAAGAATGAGAACAACAAACAGAAAACCCCGA
AAGAAAACCAATCCAATTTCTATAATATTTCAAAAGACATTTCCATTGTC
CAGTCGGCGATTTTGGGAGTGGAATTTCCTCGCTTGGACGAACAACCGTT
CGATCTGAATGAAAAGCCGCCAAACGAAGAAATGCTTCGTATATTTCGAT
TGGAGAATTTAAATTCAGATTTTTTACGAATCTTCCAACCGAGGGAATCT
TTACTATTTCCAAATGGTCGCATTCAAACCGTTCCATACAGTCTTATGAT
GAAAACATCCGATCGGAAATGGATTTTTGATCGGTTCTTAGCCCTTCCAT
ATGGCAACAACTTGAAGCCACGTCTCACTCAGAAAAAACGACGACTTATT
CGACAATTTGTAACGAATTTTAATTACTGTCCGGTATTTTATAAATGGAT
TGACAAGGGAATTAGATTCTGGCCACCTTGGGTTAAAGAGGGCCATTGTG
TTAACATTCATGGCTCCTGTAGTGTACCGTCGGGAATGTTCTGCCATGAA
GACAGCCATAAAACGGTTATGATATTTAGATATATCTGTTTGAAAAGATG
GACAAAAGACAATTGTAAATGGTACAAAATGCATATACCGATCCTTACAT
CCTGTAGATGTTCGTGTGGATAATCTGAATAATGAACCTTCTAGTTTGTT
ACATATTATTTGAATAGTTTTTGCTGAAAAAAATGTTCATTTCTATCATT
TGTTGTTGCATAAATTTCATTTTCCTTTTCTACCTCAATCGTGTGTTTTT
TCTCTCTCTAGAATAACTCTTTCATGGAATTCTCATAAGACTTCATTGAT
GCTCTGTTCAACATTAATAGATTCAAGGTTCTGAGATTTTTATCTATAAA
TATATGAATTCT

protein sequence of SMED30017196-orf-1

>SMED30017196-orf-1 ID=SMED30017196-orf-1|Name=SMED30017196-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=256bp
MKDFEVIFLLSILVILTQTLPKSGSEIISENLWKSFQMKNENNKQKTPKE
NQSNFYNISKDISIVQSAILGVEFPRLDEQPFDLNEKPPNEEMLRIFRLE
NLNSDFLRIFQPRESLLFPNGRIQTVPYSLMMKTSDRKWIFDRFLALPYG
NNLKPRLTQKKRRLIRQFVTNFNYCPVFYKWIDKGIRFWPPWVKEGHCVN
IHGSCSVPSGMFCHEDSHKTVMIFRYICLKRWTKDNCKWYKMHIPILTSC
RCSCG*

Aliases

The feature 'noggin 1' has the following synonyms


Synonym
noggin-1

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000032	dorsal midline
PLANA:0000043	dorsal ventral margin of the whole animal
PLANA:0000044	cephalic ganglia
PLANA:0000072	mouth
PLANA:0000097	ventral nerve cord
PLANA:0000103	central nervous system
PLANA:0000419	prepharyngeal region

Vocabulary: **INTERPRO**
Term	Definition
IPR008717	Noggin
IPR029034	Cystine-knot_cytokine

Vocabulary: **biological process**
Term	Definition
GO:0030514	negative regulation of BMP signaling pathway
GO:0045596	negative regulation of cell differentiation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	GENE3D	G3DSA:1.10.287.520		coord: 117..174 e-value: 8.1E-35 score: 122.6
None	No IPR available	PFAM	PF05806	Noggin	coord: 82..254 e-value: 2.6E-35 score: 122.3
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..19 score: 0.753
IPR029034	Cystine-knot cytokine	GENE3D	G3DSA:2.10.90.10		coord: 91..254 e-value: 8.1E-35 score: 122.6
IPR029034	Cystine-knot cytokine	SUPERFAMILY	SSF57501	Cystine-knot cytokines	coord: 89..254
IPR008717	Noggin	PANTHER	PTHR10494	BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN	coord: 80..254

Main menu

noggin 1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 17

Owlery

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