Dual specificity mitogen-activated protein kinase kinase 6
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017135 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 24
Homology
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K6 (mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846]) HSP 1 Score: 280.796 bits (717), Expect = 3.649e-90 Identity = 148/343 (43.15%), Postives = 215/343 (62.68%), Query Frame = 1
Query: 37 ASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
+ KK+ P K + E + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ CP+ V YGA+ R GDVWICME++D+SLDKFYK V I IPE +L I IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H F+T E+ + A++V IL +
Sbjct: 4 SKGKKRNPGLK---IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV--IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSQCLKKNSKERPTYPELMQH----PFFT--LHESKGTDVASFVKLILGD 334
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K6 (mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846]) HSP 1 Score: 270.011 bits (689), Expect = 9.900e-87 Identity = 138/286 (48.25%), Postives = 195/286 (68.18%), Query Frame = 1
Query: 208 ELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ CP+ V YGA+ R GDVWICME++D+SLDKFYK V I IPE +L I IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H F+T E+ + A++V IL +
Sbjct: 2 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV--IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSQCLKKNSKERPTYPELMQH----PFFT--LHESKGTDVASFVKLILGD 278
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K6 (mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846]) HSP 1 Score: 270.011 bits (689), Expect = 9.900e-87 Identity = 138/286 (48.25%), Postives = 195/286 (68.18%), Query Frame = 1
Query: 208 ELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ CP+ V YGA+ R GDVWICME++D+SLDKFYK V I IPE +L I IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H F+T E+ + A++V IL +
Sbjct: 2 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV--IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSQCLKKNSKERPTYPELMQH----PFFT--LHESKGTDVASFVKLILGD 278
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K4 (mitogen-activated protein kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6844]) HSP 1 Score: 273.092 bits (697), Expect = 2.585e-86 Identity = 144/343 (41.98%), Postives = 217/343 (63.27%), Query Frame = 1
Query: 58 PNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGE-KIT------ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
P FK+ + P + + +++L H+ ++ +G+ KI+ + DL+ L E+G+G +G V +M+HKPS + AVK++R + D+K+Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +S DKFYK V ++ + IPE +L IT V AL +L + L++IHRD+KPSN+L+D+SG +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S + NF++ CL R Y ELLKH + + E E A YV IL
Sbjct: 51 PPFKSTARFTLNPNPTGVQNPHIERLRTHS-IESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSV-LDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMY------EERAVEVACYVCKIL 385
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Match: MAP2K4 (mitogen-activated protein kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6844]) HSP 1 Score: 273.092 bits (697), Expect = 3.659e-86 Identity = 141/329 (42.86%), Postives = 212/329 (64.44%), Query Frame = 1
Query: 100 PVLINDNPVQQLTDHTEVQVNGE-KIT------ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
P + + +++L H+ ++ +G+ KI+ + DL+ L E+G+G +G V +M+HKPS + AVK++R + D+K+Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +S DKFYK V ++ + IPE +L IT V AL +L + L++IHRD+KPSN+L+D+SG +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S + NF++ CL R Y ELLKH + + E E A YV IL
Sbjct: 76 PTGVQNPHIERLRTHS-IESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSV-LDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMY------EERAVEVACYVCKIL 396
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: sek-1 (Dual specificity mitogen-activated protein kinase kinase sek-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EDF7]) HSP 1 Score: 255.373 bits (651), Expect = 8.488e-81 Identity = 131/321 (40.81%), Postives = 196/321 (61.06%), Query Frame = 1
Query: 115 DNPVQQLTDHTEVQV--NGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNE----FANYVTFIL 1056
+ P L D +++ E+I I+ +DL L ELGKG +GIVE+M H+ S ++ AVK+++ S +D+ Q ++LN+L+ RS CP +V YGAM R GDVWICME++D+SLDKFY+ IG IPE + + ++ L ++ + L +IHRDVKPSN+L+++ G+VK+CDFGISG L NS+A+T G + Y+ PERI E + S + +R+DVWSLG++I+E+A+ PY + + + V + PPP LP S +S + F+ RCL +R Y ELL F+E +NE A ++ IL
Sbjct: 22 ETPTMNLEDRCLIKLTNESEEIEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKIG--KHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGE-TKSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELL---------AMPFMEQARNEKQFSMARFINEIL 330
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: sek-1 (Dual specificity mitogen-activated protein kinase kinase sek-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EDF7]) HSP 1 Score: 255.373 bits (651), Expect = 8.488e-81 Identity = 131/321 (40.81%), Postives = 196/321 (61.06%), Query Frame = 1
Query: 115 DNPVQQLTDHTEVQV--NGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNE----FANYVTFIL 1056
+ P L D +++ E+I I+ +DL L ELGKG +GIVE+M H+ S ++ AVK+++ S +D+ Q ++LN+L+ RS CP +V YGAM R GDVWICME++D+SLDKFY+ IG IPE + + ++ L ++ + L +IHRDVKPSN+L+++ G+VK+CDFGISG L NS+A+T G + Y+ PERI E + S + +R+DVWSLG++I+E+A+ PY + + + V + PPP LP S +S + F+ RCL +R Y ELL F+E +NE A ++ IL
Sbjct: 22 ETPTMNLEDRCLIKLTNESEEIEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKIG--KHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGE-TKSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELL---------AMPFMEQARNEKQFSMARFINEIL 330
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: mkk-4 (MAP kinase kinase mkk-4 [Source:UniProtKB/Swiss-Prot;Acc:Q20347]) HSP 1 Score: 214.927 bits (546), Expect = 7.226e-65 Identity = 120/278 (43.17%), Postives = 171/278 (61.51%), Query Frame = 1
Query: 175 TISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSK-DDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSS---YSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSF 993
T S ++L+ L +G G FG V +M HK + + AVK++RC+ ++Q R+L + + ++S + P +V YGA+ GD WICME++D S+D YK V + S + E ++ +IT C V AL+YL + L++IHRDVKPSN+L+D +G VK+CDFGI G L S A+T + G Q YLAPERI S+ + +RSDVWSLG+++ E+A KFPY SL++ I V G PP L +S YS + FI+ CL + R Y D LKSF
Sbjct: 60 TFSSANLQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYMV-KNSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERI---TSSDKYDVRSDVWSLGITLYEIATGKFPYQEWNSLFDQIATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKY------DTLKSF 327
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: sek-3 (SAPK/ERK kinase [Source:UniProtKB/TrEMBL;Acc:Q8MPS3]) HSP 1 Score: 192.971 bits (489), Expect = 2.085e-56 Identity = 105/276 (38.04%), Postives = 164/276 (59.42%), Query Frame = 1
Query: 193 LETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRC---SKDD---KKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYP--LDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSF 993
L+ L LG G FG+V +MLH+PSN+ AVKQ+ DD K R ++ + ++ C +V YG G W+CME++D SLDK Y + I + IPE +L + + ALE+L +IHRD+KPSN+L+D+ G VK+CDFGI G L NSVAQ+ ++G + Y+APER+ + G+ I+S+VWSLG++++E+A K+PY +D + + + V G PP L + S +++ FI+ C + RAS+ +L K ++ + +
Sbjct: 71 LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHDI-QKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAP--NGDGYDIKSEVWSLGITMVEVANGKYPYDGFMDAPILDQVRMVVYGDPPILDSDHEVSMSMKRFIALCTIKDRNLRASFDDLKKTNIYRDY 343
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Match: sek-3 (SAPK/ERK kinase [Source:UniProtKB/TrEMBL;Acc:Q8MPS3]) HSP 1 Score: 192.971 bits (489), Expect = 2.085e-56 Identity = 105/276 (38.04%), Postives = 164/276 (59.42%), Query Frame = 1
Query: 193 LETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRC---SKDD---KKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYP--LDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSF 993
L+ L LG G FG+V +MLH+PSN+ AVKQ+ DD K R ++ + ++ C +V YG G W+CME++D SLDK Y + I + IPE +L + + ALE+L +IHRD+KPSN+L+D+ G VK+CDFGI G L NSVAQ+ ++G + Y+APER+ + G+ I+S+VWSLG++++E+A K+PY +D + + + V G PP L + S +++ FI+ C + RAS+ +L K ++ + +
Sbjct: 71 LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHDI-QKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAP--NGDGYDIKSEVWSLGITMVEVANGKYPYDGFMDAPILDQVRMVVYGDPPILDSDHEVSMSMKRFIALCTIKDRNLRASFDDLKKTNIYRDY 343
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: lic (gene:FBgn0261524 transcript:FBtr0073720) HSP 1 Score: 257.684 bits (657), Expect = 1.673e-81 Identity = 133/313 (42.49%), Postives = 199/313 (63.58%), Query Frame = 1
Query: 121 PVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
P + L +Q+ I LE + +LG+G +GIV++M HK ++ V AVK++ + + ++Q R++ DL+ISMRS+ CPY V YGAM+R GDVWICME++ +SLDKFY V + + E +L I +V+AL YLH L+VIHRDVKPSN+LI+++G+VK+CDFGISG LV+S+A+T + G + Y+APERI + + + + IRSDVWSLG+ ++E+A ++PY + + + V E PP LPE ++S +FI+ CL R +Y +LLKH SF + N + + +V IL
Sbjct: 22 PPRNLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKV--FLHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEG-TFSPEFEDFIAVCLQKEYMARPNYEQLLKH----SFIVEHLQRN--TDISEFVARIL 325
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: Mkk4 (gene:FBgn0024326 transcript:FBtr0334320) HSP 1 Score: 242.662 bits (618), Expect = 1.110e-74 Identity = 126/300 (42.00%), Postives = 187/300 (62.33%), Query Frame = 1
Query: 175 TISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL---PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
T + DLE E+G+G FG V +M K + V AVK++R + D+K+Q ++L DL + M+S +C Y+V YGA+ + GD WICME++D+SLDKFYK + + IPE +LA IT V AL YL + L++IHRDVKPSN+L+ + G +K+CDFGISG LV+S+A+T + G + Y+APERI E + G+ +RSDVWSLG++++E+A FPY S++ + V +G PP L +S +F++ CL+ DR Y LL+ ++ E + A YV IL++
Sbjct: 116 TFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYE-KQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERA-KGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRG------ETSHTDVAVYVADILES 407
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: Mkk4 (gene:FBgn0024326 transcript:FBtr0081892) HSP 1 Score: 242.662 bits (618), Expect = 1.110e-74 Identity = 126/300 (42.00%), Postives = 187/300 (62.33%), Query Frame = 1
Query: 175 TISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL---PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
T + DLE E+G+G FG V +M K + V AVK++R + D+K+Q ++L DL + M+S +C Y+V YGA+ + GD WICME++D+SLDKFYK + + IPE +LA IT V AL YL + L++IHRDVKPSN+L+ + G +K+CDFGISG LV+S+A+T + G + Y+APERI E + G+ +RSDVWSLG++++E+A FPY S++ + V +G PP L +S +F++ CL+ DR Y LL+ ++ E + A YV IL++
Sbjct: 116 TFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYE-KQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERA-KGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRG------ETSHTDVAVYVADILES 407
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: Mkk4 (gene:FBgn0024326 transcript:FBtr0300443) HSP 1 Score: 242.662 bits (618), Expect = 1.110e-74 Identity = 126/300 (42.00%), Postives = 187/300 (62.33%), Query Frame = 1
Query: 175 TISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL---PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
T + DLE E+G+G FG V +M K + V AVK++R + D+K+Q ++L DL + M+S +C Y+V YGA+ + GD WICME++D+SLDKFYK + + IPE +LA IT V AL YL + L++IHRDVKPSN+L+ + G +K+CDFGISG LV+S+A+T + G + Y+APERI E + G+ +RSDVWSLG++++E+A FPY S++ + V +G PP L +S +F++ CL+ DR Y LL+ ++ E + A YV IL++
Sbjct: 116 TFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYE-KQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERA-KGYDVRSDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRG------ETSHTDVAVYVADILES 407
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Match: hep (gene:FBgn0010303 transcript:FBtr0330397) HSP 1 Score: 220.32 bits (560), Expect = 2.150e-65 Identity = 119/308 (38.64%), Postives = 181/308 (58.77%), Query Frame = 1
Query: 148 EVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLP--ENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
++ +NG + ++DL+ L +LG G G V +M+H SN + AVKQ+R + + ++ RIL DL++ ++S C Y+V G R DVWICME++ DK KL ++ +PE +L +T V AL YL VIHRDVKPSN+LID+ G +K+CDFGISG LV+S A T + G +Y+APERI + + IR+DVWSLG++++ELA + PY + + ++T V + PP LP E ++S R+F+ +CL +DR Y ELL ++ + E+ + + N+ I N
Sbjct: 182 KLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKL-----SKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERI--DPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIY------ESAKVDVPNWFQSIKDN 476
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239]) HSP 1 Score: 276.174 bits (705), Expect = 3.187e-88 Identity = 142/315 (45.08%), Postives = 205/315 (65.08%), Query Frame = 1
Query: 121 PVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
P + L V + + + DLE + ELG+G +G+V++M H PS ++ AVK++R + + ++Q R+L DL+ISMR+ C Y V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L IT IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G+ ++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL +R +Y EL++H F+T ++ + A++V IL +
Sbjct: 56 PPRDLDSKAYVTIGEKNFVVKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEKGKT--IPEDILGKITVSIVKALEHLHSNLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-RFSADFVDFTSQCLRKNSTERPTYTELMQH----PFFT--LHDSKDTDVASFVKTILGD 361
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239]) HSP 1 Score: 276.174 bits (705), Expect = 3.426e-88 Identity = 142/315 (45.08%), Postives = 205/315 (65.08%), Query Frame = 1
Query: 121 PVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
P + L V + + + DLE + ELG+G +G+V++M H PS ++ AVK++R + + ++Q R+L DL+ISMR+ C Y V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L IT IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G+ ++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL +R +Y EL++H F+T ++ + A++V IL +
Sbjct: 58 PPRDLDSKAYVTIGEKNFVVKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEKGKT--IPEDILGKITVSIVKALEHLHSNLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-RFSADFVDFTSQCLRKNSTERPTYTELMQH----PFFT--LHDSKDTDVASFVKTILGD 363
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k4a (mitogen-activated protein kinase kinase 4a [Source:ZFIN;Acc:ZDB-GENE-060512-98]) HSP 1 Score: 271.166 bits (692), Expect = 5.190e-86 Identity = 143/344 (41.57%), Postives = 215/344 (62.50%), Query Frame = 1
Query: 55 PPNFKTFNLKSGIIEPVLINDNP-VQQLTDHT-----EVQVNGEK-ITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
PP T + SG L NP +++L H+ +++++ E+ + DL+ L E+G+G +G V +M HKPS + AVK++R + D+++Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +S DKFYK V + + IPE +L IT V AL +L + L++IHRD+KPSN+L+D+ G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S NF++ CL R Y ELLKH ++ + +S + A YV IL
Sbjct: 33 PPIKTTSRITSG-----LPFQNPHIERLRTHSIESSGKLKISAEQHCDFTAEDLKDLGEIGRGAYGSVNKMAHKPSGQIMAVKRIRSTVDEREQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYS-SLDEVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSSSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHAFIQMYEERSV------DVATYVCRIL 364
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k4a (mitogen-activated protein kinase kinase 4a [Source:ZFIN;Acc:ZDB-GENE-060512-98]) HSP 1 Score: 271.552 bits (693), Expect = 7.764e-86 Identity = 143/344 (41.57%), Postives = 215/344 (62.50%), Query Frame = 1
Query: 55 PPNFKTFNLKSGIIEPVLINDNP-VQQLTDHT-----EVQVNGEK-ITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
PP T + SG L NP +++L H+ +++++ E+ + DL+ L E+G+G +G V +M HKPS + AVK++R + D+++Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +S DKFYK V + + IPE +L IT V AL +L + L++IHRD+KPSN+L+D+ G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S NF++ CL R Y ELLKH ++ + +S + A YV IL
Sbjct: 59 PPIKTTSRITSG-----LPFQNPHIERLRTHSIESSGKLKISAEQHCDFTAEDLKDLGEIGRGAYGSVNKMAHKPSGQIMAVKRIRSTVDEREQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYS-SLDEVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSSSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHAFIQMYEERSV------DVATYVCRIL 390
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Match: map2k4b (mitogen-activated protein kinase kinase 4b [Source:ZFIN;Acc:ZDB-GENE-080721-13]) HSP 1 Score: 268.855 bits (686), Expect = 1.211e-84 Identity = 127/272 (46.69%), Postives = 186/272 (68.38%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLL 984
+ DL+ L E+G+G +G V M+HKPS + AVK++R + D+K+Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +SLDKFYK V ++ IPE +L IT V AL +L + L++IHRD+KPSN+L+D++G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E+ +S+ F++ CL R Y ELLKH +
Sbjct: 115 FTAEDLKDLGEIGRGAYGSVNNMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMATSLDKFYKYVYC-ASDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPRWNSVFDQLTQVVKGEPPQLCSSEDRQFSHKFIQFVNLCLTKDESKRPKYRELLKHPFI 385
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132]) HSP 1 Score: 279.641 bits (714), Expect = 8.807e-90 Identity = 149/342 (43.57%), Postives = 216/342 (63.16%), Query Frame = 1
Query: 40 SSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
+ KKK P K K +P + + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ C + V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L I IV ALE+LH L VIHRDVKPSNVLI+K G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H F+ E+ + A++V IL +
Sbjct: 4 AGKKKNPGLKI--PKEAFDQPQVSSPTPPRDLDSKACILIGEKNFEVKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKGLT--IPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSKCLKKNSKERPTYPELMQH----HFFV--LHESKNTDVASFVKRILGD 334
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132]) HSP 1 Score: 278.1 bits (710), Expect = 6.469e-89 Identity = 143/315 (45.40%), Postives = 203/315 (64.44%), Query Frame = 1
Query: 43 SKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLL 984
KKK P K K +P + + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ C + V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L I IV ALE+LH L VIHRDVKPSNVLI+K G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H
Sbjct: 26 GKKKNPGLKI--PKEAFDQPQVSSPTPPRDLDSKACILIGEKNFEVKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKGLT--IPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSKCLKKNSKERPTYPELMQHHFF 335
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132]) HSP 1 Score: 277.33 bits (708), Expect = 7.097e-89 Identity = 149/344 (43.31%), Postives = 215/344 (62.50%), Query Frame = 1
Query: 34 MASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
M KK P K K +P + + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ C + V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L I IV ALE+LH L VIHRDVKPSNVLI+K G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H F+ E+ + A++V IL +
Sbjct: 3 MPRPYKKNPGLKI--PKEAFDQPQVSSPTPPRDLDSKACILIGEKNFEVKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKGLT--IPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSKCLKKNSKERPTYPELMQH----HFFV--LHESKNTDVASFVKRILGD 335
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132]) HSP 1 Score: 278.87 bits (712), Expect = 4.212e-88 Identity = 148/339 (43.66%), Postives = 212/339 (62.54%), Query Frame = 1
Query: 43 SKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
KKK P K K +P + + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ C + V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L I IV ALE+LH L VIHRDVKPSNVLI+K G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H E+ + A++V IL
Sbjct: 106 GKKKNPGLKI--PKEAFDQPQVSSPTPPRDLDSKACILIGEKNFEVKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKGLT--IPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSKCLKKNSKERPTYPELMQHHFF------VLHESKNTDVASFVKRIL 433
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:448132]) HSP 1 Score: 272.322 bits (695), Expect = 1.812e-87 Identity = 134/270 (49.63%), Postives = 187/270 (69.26%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLL 984
+ DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ C + V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L I IV ALE+LH L VIHRDVKPSNVLI+K G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H
Sbjct: 11 VKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKGLT--IPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSKCLKKNSKERPTYPELMQHHFF 277
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k6 (mitogen-activated protein kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1346870]) HSP 1 Score: 279.256 bits (713), Expect = 1.071e-89 Identity = 147/343 (42.86%), Postives = 215/343 (62.68%), Query Frame = 1
Query: 37 ASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
+ KK+ P K + E + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL++SMR+ CP+ V YGA+ R GDVWICME++D+SLDKFYK V I IPE +L I IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H F+T E+ + A++V IL +
Sbjct: 4 SKGKKRNPGLK---IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV--IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSADFVDFTSQCLKKNSKERPTYPELMQH----PFFT--VHESKAADVASFVKLILGD 334
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k3 (mitogen-activated protein kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346868]) HSP 1 Score: 272.707 bits (696), Expect = 4.708e-87 Identity = 143/325 (44.00%), Postives = 208/325 (64.00%), Query Frame = 1
Query: 85 SGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
S + +P + N P + L T + + + DL T++ELG+G +G+VE++ H S + AVK++R + + ++Q R+L DL+I+MR+ C Y V YGA+ R GDVWICME++D+SLDKFY+ V + IPE +L I IV ALE+LH L VIHRDVKPSNVLI+K G VK+CDFGISG LV+SVA+T + G + Y+APERI E + G+ ++SDVWSLG++++E+AIL+FPY + + + V E P P LP + +S +F S+CL +R SYLEL++H F+T + + + A +V IL
Sbjct: 28 SCVSKPPVSNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKV--LEKNMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD-QFSPEFVDFTSQCLRKNPAERMSYLELMEH----PFFT--LHKTKKTDIAAFVKEIL 343
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k4 (mitogen-activated protein kinase kinase 4 [Source:MGI Symbol;Acc:MGI:1346869]) HSP 1 Score: 272.322 bits (695), Expect = 2.951e-86 Identity = 134/296 (45.27%), Postives = 196/296 (66.22%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
+ DL+ L E+G+G +G V +M+HKPS + AVK++R + D+K+Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +S DKFYK V ++ + IPE +L IT V AL +L + L++IHRD+KPSN+L+D+SG +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S + NF++ CL R Y ELLKH + + ++ E A YV IL
Sbjct: 95 FTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSV-LDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTV------EVACYVCKIL 383
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k6 (mitogen-activated protein kinase kinase 6 [Source:MGI Symbol;Acc:MGI:1346870]) HSP 1 Score: 259.61 bits (662), Expect = 1.225e-82 Identity = 132/296 (44.59%), Postives = 190/296 (64.19%), Query Frame = 1
Query: 37 ASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISR 921
+ KK+ P K + E + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL++SMR+ CP+ V YGA+ R GDVWICME++D+SLDKFYK V I IPE +L I IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+
Sbjct: 4 SKGKKRNPGLK---IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV--IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSADFVDFTSQ 293
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Match: Map2k7 (mitogen-activated protein kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346871]) HSP 1 Score: 216.083 bits (549), Expect = 2.860e-65 Identity = 114/296 (38.51%), Postives = 181/296 (61.15%), Query Frame = 1
Query: 115 DNPVQQLTDHTE-VQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTS-GFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSF 993
D +Q++ T + + G++ ++DLE L E+G G G V +M + + + AVKQ+R S + ++ RIL DL++ ++S CPY+V +G DV+I ME++ + +K K + + IPE +L +T IV AL YL + VIHRDVKPSN+L+D+ G++K+CDFGISG LV+S A+T + G +Y+APERI + T + IR+DVWSLG+S++ELA +FPY + + ++T V + PP LP + +S ++F+ CL + R Y +LL+H +K +
Sbjct: 20 DQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRM-----QGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHY 310
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|P52564|MP2K6_HUMAN (Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP2K6 PE=1 SV=1) HSP 1 Score: 280.796 bits (717), Expect = 1.752e-89 Identity = 148/343 (43.15%), Postives = 215/343 (62.68%), Query Frame = 1
Query: 37 ASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
+ KK+ P K + E + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ CP+ V YGA+ R GDVWICME++D+SLDKFYK V I IPE +L I IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H F+T E+ + A++V IL +
Sbjct: 4 SKGKKRNPGLK---IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV--IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSQCLKKNSKERPTYPELMQH----PFFT--LHESKGTDVASFVKLILGD 334
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|Q5E9X2|MP2K6_BOVIN (Dual specificity mitogen-activated protein kinase kinase 6 OS=Bos taurus OX=9913 GN=MAP2K6 PE=2 SV=1) HSP 1 Score: 280.411 bits (716), Expect = 2.499e-89 Identity = 148/341 (43.40%), Postives = 214/341 (62.76%), Query Frame = 1
Query: 37 ASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
+ KK+ P K + E + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL+ISMR+ CP+ V YGA+ R GDVWICME++D+SLDKFYK V I IPE +L I IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H F+T E+ + A++V IL
Sbjct: 4 SKGKKRNPGLK---IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV--IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSEEFVDFTSQCLKKNSKERPTYPELMQH----PFFT--LHESKATDVASFVKSIL 332
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|P70236|MP2K6_MOUSE (Dual specificity mitogen-activated protein kinase kinase 6 OS=Mus musculus OX=10090 GN=Map2k6 PE=1 SV=1) HSP 1 Score: 279.256 bits (713), Expect = 7.491e-89 Identity = 147/343 (42.86%), Postives = 215/343 (62.68%), Query Frame = 1
Query: 37 ASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
+ KK+ P K + E + P + L + + + + DLE + ELG+G +G+VE+M H PS + AVK++R + + ++Q R+L DL++SMR+ CP+ V YGA+ R GDVWICME++D+SLDKFYK V I IPE +L I IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G++++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL K+R +Y EL++H F+T E+ + A++V IL +
Sbjct: 4 SKGKKRNPGLK---IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV--IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSADFVDFTSQCLKKNSKERPTYPELMQH----PFFT--VHESKAADVASFVKLILGD 334
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|Q9DGE0|MP2K6_DANRE (Dual specificity mitogen-activated protein kinase kinase 6 OS=Danio rerio OX=7955 GN=map2k6 PE=1 SV=2) HSP 1 Score: 276.174 bits (705), Expect = 2.406e-87 Identity = 142/315 (45.08%), Postives = 205/315 (65.08%), Query Frame = 1
Query: 121 PVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
P + L V + + + DLE + ELG+G +G+V++M H PS ++ AVK++R + + ++Q R+L DL+ISMR+ C Y V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L IT IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G+ ++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+CL +R +Y EL++H F+T ++ + A++V IL +
Sbjct: 56 PPRDLDSKAYVTIGEKNFVVKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEKGKT--IPEDILGKITVSIVKALEHLHSNLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-RFSADFVDFTSQCLRKNSTERPTYTELMQH----PFFT--LHDSKDTDVASFVKTILGD 361
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Match: sp|O09110|MP2K3_MOUSE (Dual specificity mitogen-activated protein kinase kinase 3 OS=Mus musculus OX=10090 GN=Map2k3 PE=1 SV=2) HSP 1 Score: 272.707 bits (696), Expect = 3.293e-86 Identity = 143/325 (44.00%), Postives = 208/325 (64.00%), Query Frame = 1
Query: 85 SGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
S + +P + N P + L T + + + DL T++ELG+G +G+VE++ H S + AVK++R + + ++Q R+L DL+I+MR+ C Y V YGA+ R GDVWICME++D+SLDKFY+ V + IPE +L I IV ALE+LH L VIHRDVKPSNVLI+K G VK+CDFGISG LV+SVA+T + G + Y+APERI E + G+ ++SDVWSLG++++E+AIL+FPY + + + V E P P LP + +S +F S+CL +R SYLEL++H F+T + + + A +V IL
Sbjct: 28 SCVSKPPVSNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKV--LEKNMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD-QFSPEFVDFTSQCLRKNPAERMSYLELMEH----PFFT--LHKTKKTDIAAFVKEIL 343
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: A0A0X3PTZ8 (Dual specificity mitogen-activated protein kinase kinase 6 OS=Schistocephalus solidus OX=70667 GN=MP2K6 PE=3 SV=1) HSP 1 Score: 330.102 bits (845), Expect = 5.005e-106 Identity = 168/343 (48.98%), Postives = 235/343 (68.51%), Query Frame = 1
Query: 40 SSKKKPPNFKTFNL---KSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQ 1059
S+KK+PP K F + GII PV I P +LT+ T+V V +++TI +++ ++ELG+GQF V++M+H PS VFAVK+L + + RILND NISMR+++CPY ++SYGA+ G++WI ME++D+SLDKF + V E IPE +LAYITFC+VTALEYLH+ L VIHRDVKPSN+L+D+ GRVKVCDFGISG L NS+A++N+GT +YLAPERI T GF I+SDVWSLGL++LELA +FPY ++++ + V + PP LP +S YS +R+FI+ CLV RA+Y+ LL+ ++S +V+ E N F ++
Sbjct: 9 SAKKRPPALKNFAIGHHAPGIILPVEIA--PGTKLTNETDVIVGEKQVTIRANEMRLVSELGQGQFAYVQKMVHDPSGCVFAVKRLPFHSETPDRSRILNDYNISMRTSKCPYAIMSYGALSYVGEIWIVMELMDASLDKFLEKVYE--KEEIIPENLLAYITFCVVTALEYLHKDLHVIHRDVKPSNILVDRLGRVKVCDFGISGELTNSLAKSNIGTHNYLAPERIDPLQGTQGFRIQSDVWSLGLTLLELATGEFPYGNFPNVFSQLQQVVKQEPPKLPSDSPYSEDLRSFIADCLVKDETQRANYVTLLESKFIRSV-------DVEREAINLADFFVR 340
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: A0A158QT70 (Protein kinase domain-containing protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS2233 PE=4 SV=1) HSP 1 Score: 307.375 bits (786), Expect = 2.533e-97 Identity = 153/302 (50.66%), Postives = 207/302 (68.54%), Query Frame = 1
Query: 88 GIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERI-ITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKS 990
G+I PV I P QL++ T+V +NG+K+TI DLE ELG+G++ V +M H PSN FAVK+L + + RILND N+SMR++ CPY V+SYGA+ G + W+ ME++D SLDKF + V A G IPE +LAYI FC+VTALEYL + L +HRDVKPSN+LID++G VKVCD+G+SG L NS+AQ+N GT Y+APERI T ++ GF I++DVWSLGL++LELA K PY ++ + L+ +V PP +PE YS R+ +S+CLV RA+YL LL+ L+S
Sbjct: 20 GVILPVEIG--PSTQLSNRTDVIINGQKVTIDARDLEVKEELGRGEYARVHKMFHPPSNCEFAVKRLPFEIETSDRSRILNDWNVSMRTSTCPYAVLSYGALSVGCEFWVVMELMDDSLDKFLQKVYAQG--KVIPENLLAYIAFCVVTALEYLRKDLVTMHRDVKPSNILIDRAGHVKVCDYGVSGELKNSMAQSNTGTCRYMAPERIDPTRSAGGGFRIQADVWSLGLTLLELATGKHPYEGFVNQFELLKHVVHEAPPHVPETVPYSQDFRDLVSQCLVKEESARANYLRLLESPFLRS 317
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: G9I624 (EgMKK1 OS=Echinococcus granulosus OX=6210 GN=MKK1 PE=4 SV=1) HSP 1 Score: 305.449 bits (781), Expect = 1.658e-96 Identity = 155/319 (48.59%), Postives = 209/319 (65.52%), Query Frame = 1
Query: 37 ASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENST-SGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKS 990
A + P N G+I PV I P QL++ T+V +NG+K+TI DLE ELG+G++ V +M H PS FAVK+L + + RILND N+SMR++ CPY V+SYGA+ G + W+ ME++D SLDKF + V A G IPE +LAYI FC+VTALEYL + L +HRDVKPSN+LID++G VKVCD+G+SG L NS+AQ+N GT Y+APERI S GF I++DVWSLGL++LELA K PY ++ + L+ +V PP++PE+ YS R+ +S+CLV RA+YL LL L+S
Sbjct: 3 AVRRPLPLNLGETRRIPGVILPVEIG--PSTQLSNRTDVIINGQKVTIDARDLEVKEELGRGEYARVHRMYHAPSKCEFAVKRLPFEVETSDRSRILNDWNVSMRTSTCPYAVLSYGALSVGCEFWVVMELMDDSLDKFLQKVYAQG--KIIPENLLAYIAFCVVTALEYLRKDLVTMHRDVKPSNILIDRAGHVKVCDYGVSGELKNSMAQSNTGTCRYMAPERIDPSRSAGGGFRIQADVWSLGLTLLELATGKHPYESFVNRFELLKHVVHEAPPNVPESVPYSQDFRDIVSQCLVKEESARANYLRLLDSPFLRS 317
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: A0A068WTA2 (Dual specificity mitogen activated protein OS=Echinococcus granulosus OX=6210 GN=EgrG_000121500 PE=4 SV=1) HSP 1 Score: 305.449 bits (781), Expect = 1.676e-96 Identity = 155/319 (48.59%), Postives = 209/319 (65.52%), Query Frame = 1
Query: 37 ASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENST-SGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKS 990
A + P N G+I PV I P QL++ T+V +NG+K+TI DLE ELG+G++ V +M H PS FAVK+L + + RILND N+SMR++ CPY V+SYGA+ G + W+ ME++D SLDKF + V A G IPE +LAYI FC+VTALEYL + L +HRDVKPSN+LID++G VKVCD+G+SG L NS+AQ+N GT Y+APERI S GF I++DVWSLGL++LELA K PY ++ + L+ +V PP++PE+ YS R+ +S+CLV RA+YL LL L+S
Sbjct: 3 AVRRPLPLNLGETRRIPGVILPVEIG--PSTQLSNRTDVIINGQKVTIDARDLEVKEELGRGEYARVHRMYHAPSKCEFAVKRLPFEVETSDRSRILNDWNVSMRTSTCPYAVLSYGALSVGCEFWVVMELMDDSLDKFLQKVYAQG--KIIPENLLAYIAFCVVTALEYLRKDLVTMHRDVKPSNILIDRAGHVKVCDYGVSGELKNSMAQSNTGTCRYMAPERIDPSRSAGGGFRIQADVWSLGLTLLELATGKHPYESFVNQFELLKHVVHEAPPNVPESVPYSQDFRDIVSQCLVKEESARANYLRLLDSPFLRS 317
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. TrEMBL
Match: A0A0R3WCQ2 (Protein kinase domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS8497 PE=4 SV=1) HSP 1 Score: 304.679 bits (779), Expect = 2.695e-96 Identity = 155/319 (48.59%), Postives = 209/319 (65.52%), Query Frame = 1
Query: 37 ASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENST-SGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKS 990
A + P N G+I PV I P QL++ T+V +NG+K+TI DLE ELG+G++ V +M H PS FAVK+L + + RILND N+SMR++ CPY V+SYGA+ G + W+ ME++D SLDKF + V A + IPE +LAYI FC+VTALEYL + L +HRDVKPSN+LID+SG VKVCD+G+SG L NS+AQ+N GT Y+APERI S GF I++DVWSLGL++LELA K PY ++ + L+ +V PP++PE+ YS R+ +S+CLV RA+YL LL L+S
Sbjct: 3 AVRRPLPLNLGETRRIPGVILPVEIG--PSTQLSNRTDVIINGQKVTIDARDLEVKEELGRGEYARVHRMYHAPSKCEFAVKRLPFEVETSDRSRILNDWNVSMRTSTCPYAVLSYGALSVGCEFWVVMELMDDSLDKFLQKVYA--QDKIIPENLLAYIAFCVVTALEYLRKDLVTMHRDVKPSNILIDRSGHVKVCDYGVSGELKNSMAQSNTGTCRYMAPERIDPSRSAGGGFRIQADVWSLGLTLLELATGKHPYESFVNQFELLKHVVHEAPPNVPESVPYSQDFRDIVSQCLVKEESARANYLRLLDSPFLRS 317
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k4a (mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:103045018]) HSP 1 Score: 271.937 bits (694), Expect = 8.355e-86 Identity = 135/296 (45.61%), Postives = 195/296 (65.88%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
+ DL+ L E+G+G +G V +M HKPS + AVK++R + D+K+Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +SLDKFYK V + E IPE +L IT V AL +L + L++IHRD+KPSN+L+D++G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S NF++ CL R Y ELLKH + + +S + A+YV IL
Sbjct: 120 FTAEDLKDLGEIGRGAYGSVNKMAHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVEFYGALFREGDCWICMELMSTSLDKFYKYVYST-LEDVIPEEILGKITLVTVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEERQFSPKFINFVNLCLTKDESKRPKYRELLKHPFILMYEERSV------DVASYVCRIL 408
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k4b (dual specificity mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:103042940]) HSP 1 Score: 269.24 bits (687), Expect = 1.361e-85 Identity = 135/296 (45.61%), Postives = 195/296 (65.88%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
+ DL+ L E+G+G +G V +M+HKPS + AVK++R + D+K+Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +S DKFYK V + IPE +L IT V AL +L + L++IHRD+KPSN+L+D++G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S NF++ CL R Y ELLKH + Q + E V + A+YV IL
Sbjct: 62 FTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYC-SLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLINSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHPFI-----QMYEERVVD-VASYVCKIL 350
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k4b (dual specificity mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:103042940]) HSP 1 Score: 269.24 bits (687), Expect = 6.466e-85 Identity = 135/296 (45.61%), Postives = 195/296 (65.88%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
+ DL+ L E+G+G +G V +M+HKPS + AVK++R + D+K+Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +S DKFYK V + IPE +L IT V AL +L + L++IHRD+KPSN+L+D++G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S NF++ CL R Y ELLKH + Q + E V + A+YV IL
Sbjct: 112 FTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYC-SLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLINSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHPFI-----QMYEERVV-DVASYVCKIL 400
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k4b (dual specificity mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:103042940]) HSP 1 Score: 269.626 bits (688), Expect = 7.341e-85 Identity = 135/296 (45.61%), Postives = 195/296 (65.88%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
+ DL+ L E+G+G +G V +M+HKPS + AVK++R + D+K+Q ++L DL++ MRS+ CPY+V YGA+ R GD WICME++ +S DKFYK V + IPE +L IT V AL +L + L++IHRD+KPSN+L+D++G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S NF++ CL R Y ELLKH + Q + E V + A+YV IL
Sbjct: 123 FTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYC-SLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLINSEERQFSPKFINFVNLCLTKDESKRPKYKELLKHPFI-----QMYEERVV-DVASYVCKIL 411
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239]) HSP 1 Score: 248.054 bits (632), Expect = 1.175e-77 Identity = 135/302 (44.70%), Postives = 193/302 (63.91%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFC--------IVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
+ DLE + ELG+G +G+V++M H PS ++ AVK++R + + ++Q R+L DL+ISMR+ C Y V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L IV ALE+LH L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G+ ++SD+WSLG++++ELAIL+FPY + + + V E P P LP + +S +F S+ V S+L+L L F+T ++ + + A++V IL
Sbjct: 48 VKADDLEQIGELGRGAYGVVDKMRHVPSGVIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHEKGKT--IPEDILGRCVISVTVLLNVQIVKALEHLHSRLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-RFSPEFVDFTSKWWVTPPN---SHLQLT---FLHPFFTCH--DSKETDVASFVKGIL 338
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: map2k6 (mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:65239]) HSP 1 Score: 269.626 bits (688), Expect = 1.433e-86 Identity = 140/316 (44.30%), Postives = 205/316 (64.87%), Query Frame = 1
Query: 121 PVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQN-EFANYVTFILQN 1062
P + L + ++ + + DLE++ ELG+G +G+VE++ H PS + AVK++R + + ++Q R+L DL+ISMR+ CPY V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L I+ IV ALE+LH L VIHRDVKPSNVLI+ G VK+CDFGISG LV+SVA+T + G + Y+APERI E + G+ ++SD+WSLG++++ELAILKFPY + + + V E P P LP ++S +F + CL +R +Y EL+ + +F+ + N ++ + A +V IL +
Sbjct: 42 PPRDLDSKACITIDDKNFEVKADDLESICELGRGAYGVVERVRHTPSGTIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPYTVTFYGALFREGDVWICMELMDTSLDKFYKKVIEKGLT--IPEDILGKISVAIVKALEHLHSKLSVIHRDVKPSNVLINTQGHVKMCDFGISGYLVDSVAKTLDAGCKPYMAPERINPEINQKGYNVKSDIWSLGITMIELAILKFPYESWGTPFQQLKQVVEEPSPQLPP-ENFSPEFVDFSTLCLKKNPNERPTYAELMDN----TFFG---IHNAKDTDVATFVKLILGD 347
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: map2k4b (mitogen-activated protein kinase kinase 4b [Source:ZFIN;Acc:ZDB-GENE-080721-13]) HSP 1 Score: 261.922 bits (668), Expect = 2.225e-83 Identity = 127/277 (45.85%), Postives = 185/277 (66.79%), Query Frame = 1
Query: 163 GEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLL 984
G++ + DL+ L E+G+G +G V +M H S + AVK++R + D+K+Q ++L DL++ M S+ CPY+V +GA+ R GD WICME++ +S DKFYK V ++ IPE +L IT V AL YL + L++IHRDVKPSN+L+D+ G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG++++ELA KFPYP S+++ +T V +G PP L E +S + NF++ CL R Y ELLKH +
Sbjct: 57 GQQYDFTADDLKDLGEIGRGAYGSVNKMQHNHSAHIMAVKRIRSTVDEKEQKQLLMDLDVVM-SSDCPYIVQFFGALFREGDCWICMELMSTSFDKFYKFVYCT-SDDVIPEEILGKITLATVKALNYLKENLKIIHRDVKPSNILLDRRGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLIELATGKFPYPKWNSVFDQLTQVVKGDPPQLSNSEERQFSASFINFVNSCLTKDESRRPKYRELLKHPFI 331
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: map2k7 (mitogen-activated protein kinase kinase 7 [Source:ZFIN;Acc:ZDB-GENE-090312-186]) HSP 1 Score: 222.631 bits (566), Expect = 3.732e-68 Identity = 121/317 (38.17%), Postives = 192/317 (60.57%), Query Frame = 1
Query: 115 DNPVQQLTDHTE-VQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENST-SGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
D +Q++ + T + ++G++ +S+LETL E+G G G V +M +KP++ + AVKQ+R S + + RIL DL++ ++S CPY+V +G+ DV+I ME++ + +K K + + IPE +L +T IV AL YL + VIHRDVKPSN+L+D GR+K+CDFGISG LV+S A+T G +Y+APERI + T + IR+DVWSLG+S++ELA +FPY + + ++T V + PP LP + +S + F+ CL + R Y +LL+H L+ + E V+ + A + ++
Sbjct: 49 DQKLQEIMNQTGFLTLDGKRYRADISELETLGEMGSGTCGQVWKMRYKPTSHILAVKQMRRSGNKDENKRILMDLDVVLKSHDCPYIVQCHGSFITNTDVFIAMELMGTCAEKLKKRI-----QGPIPENILGKMTVAIVKALSYLKEKHGVIHRDVKPSNILLDSRGRIKLCDFGISGRLVDSKAKTRGAGCAAYMAPERIDPPDPTHPDYDIRADVWSLGISLVELATGQFPYQNCKTDFEVLTKVLQEDPPLLPSDMGFSLDFQAFVKDCLTKDHRKRPKYNKLLEHAFLRRY------ERVEVDVATWFRDVM 354
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004725.1 (pep scaffold:Pmarinus_7.0:GL477683:141377:157028:-1 gene:ENSPMAG00000004255.1 transcript:ENSPMAT00000004725.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 169.859 bits (429), Expect = 8.685e-49 Identity = 81/209 (38.76%), Postives = 135/209 (64.59%), Query Frame = 1
Query: 190 DLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDS-SLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYP 813
D E L+ELG G G+V ++LHKPS L+ A K + +++I+ +L + + PY+V YGA + G++ ICME +D SLD K I PE +L ++ ++ L YL + +++HRDVKPSN+L++ G +K+CDFG+SG L++S+A + +GT+SY++PER+ + ++++SD+WS+GLS++E+AI ++P P
Sbjct: 45 DFEKLSELGAGNGGVVTKVLHKPSALIMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDLVLKKAGRI------PEEILGKVSIAVIKGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERL----QGTHYSVQSDIWSMGLSLVEMAIGRYPIP 242
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92]) HSP 1 Score: 109.383 bits (272), Expect = 3.991e-26 Identity = 89/298 (29.87%), Postives = 153/298 (51.34%), Query Frame = 1
Query: 181 SMSDLETL----NELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILD--SSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVK--PSNVLIDKSGRVKVCDFGISGTLVNSVAQTN--LGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLL-KSFYTQSFLENVQNEFANY 1041
S +D E L +GKG FG V + + + V A+K + + + + + I ++ + + PYV +G+ +G +WI ME L S+LD L+ E E +A I I+ L+YLH + R IHRD+K +NVL+ + G VK+ DFG++G L ++ + N +GT ++APE I S + ++D+WSLG++ +ELA + P ++ ++ + + PP+L N YS + F+ CL + R + ELLKH + +S S+L + + + +
Sbjct: 18 SCADPEELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITV-LSQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALD----LIKPGPLE----EHQIATILREILKGLDYLH-SERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI----KQSAYDFKADIWSLGITAIELAKGEPPN-SELHPMRVLFLIPKNNPPTLEGN--YSKAFKEFVDSCLNKDPQFRPTAKELLKHKFIQRSAKKTSYLTELIDRYKRW 298
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: PBS2 (MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000003664]) HSP 1 Score: 226.868 bits (577), Expect = 4.979e-67 Identity = 126/314 (40.13%), Postives = 195/314 (62.10%), Query Frame = 1
Query: 160 NGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILD-SSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKS-GRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITEN-STSGFTIRSDVWSLGLSILELAILKFPYPLDI--SLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQ-NN*ILLKR 1083
NG I++ +LE L+ELG G +G V ++LHKP+N++ A K++R D+ K +IL +L + + PY+V YGA G V++CME +D SLDK Y S IG I E LA+I ++ L+ L + +IHRDVKP+N+L + G VK+CDFG+SG LV S+A+TN+G QSY+APERI + N + +T++SD+WSLGLSILE+A+ ++PYP + ++++ ++ + +GPPP LP + +S+ ++F+S CL + R +Y L +H L + Q + Y+T L+ N IL +R
Sbjct: 349 NGSSSRITLDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEV-LHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGG---IDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALGRYPYPPETYDNIFSQLSAIVDGPPPRLPSD-KFSSDAQDFVSLCLQKIPERRPTYAALTEHPWLVKYRNQDV------HMSEYITERLERRNKILRER 651
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: STE7 (Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway [Source:SGD;Acc:S000002318]) HSP 1 Score: 167.548 bits (423), Expect = 1.932e-46 Identity = 97/292 (33.22%), Postives = 167/292 (57.19%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQ-DRILNDLNISMRSTQCPYVVVSYGA---MHRGGDVWICMEILD-SSLDKF---YKLVSAIGT----ESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPY----PLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQS 1005
I + DL L ++G G G V + LH P + + A K + +++ ++++ +L+I ++ YGA H ++ I ME D SLDK YK GT +++ E+ ++ I + ++ L++L++ ++IHRD+KPSNVLI+ G++K+CDFG+S L+NS+A T +GT +Y++PERI + ++I+ DVWSLGL I+EL +FP + +L+ + P P LP++ YS + +F++RC + ++R+S ELL HDL+ + + S
Sbjct: 186 IQLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERI----QGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLIMKYVSPS 473
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757]) HSP 1 Score: 153.295 bits (386), Expect = 3.134e-41 Identity = 104/300 (34.67%), Postives = 163/300 (54.33%), Query Frame = 1
Query: 124 VQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRC-SKDDKKQDRILNDLNISMRSTQCPYVVVSYGAM--HRGGDVWICMEILDS-SLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFP-----YPLDISLYNLITYVTEGPPPSLPENSS---YSNTVRNFISRCLVIAVKDRASYLELLKHDLLK 987
+ + D ++ NG K +ETL LG+G G V + K + +FA+K + + D + Q +I +L + RS Q Y+V YG ++I ME + SLD YK + G I E +L I ++ L YLH+ +VIHRD+KP N+L++++G+VK+CDFG+SG VNS+A T GT Y+APERI + +++ SDVWSLGL+ILE+A KFP +I+ + L+ ++ P E S +S + ++FI CL ++R S +++ H +K
Sbjct: 198 LNSVRDVDQLDENGWKYANLKDRIETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFN-RSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGR--ISEKVLGKIAEAVLRGLSYLHEK-KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQ----PYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWIK 489
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061]) HSP 1 Score: 146.747 bits (369), Expect = 5.185e-39 Identity = 97/274 (35.40%), Postives = 153/274 (55.84%), Query Frame = 1
Query: 190 DLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRC-SKDDKKQDRILNDLNISMRSTQCPYVVVSYGAM--HRGGDVWICMEILDS-SLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLD-----ISLYNLITYVTEGPP--PSLPE-NSSYSNTVRNFISRCLVIAVKDRASYLELLKH 975
++ TL LG+G G V + K VFA+K + + D + Q +I +L + +S + Y+V YG + ++I ME + SL+ YK + G I E ++ I ++ L YLH+ +VIHRD+KP N+L+++ G +K+CDFG+SG VNS+A T GT Y+APERI + +++ DVWSLGL++LE+A +FP+ D ++ L+T + P PE + S+S T R+FI CL ++R S ++LKH
Sbjct: 213 EITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFN-KSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGR--ISERVIGKIAESVLRGLSYLHER-KVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQ----PYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKH 478
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 110.923 bits (276), Expect = 3.734e-26 Identity = 80/266 (30.08%), Postives = 134/266 (50.38%), Query Frame = 1
Query: 211 LGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICME-ILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVA---QTNLGTQSYLAPERIITENSTSG--FTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKS 990
+G+G+FG+V + + + V+A+K L D + + + ++ Q + YG+ + +WI ME SL + I E + I ++ AL+ +H+ VIHRD+K +NVLI G VK+CDFG++ VN + QT GT ++APE I+ G + + D+WSLG++ E+A PY D+ + + + PP L E+ SYS +++ FI+ CL K+R S +LLK +++
Sbjct: 29 IGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLR-------PGKIDEKYIGVIMRELLVALKCIHKD-NVIHRDIKAANVLITNEGNVKLCDFGVAAQ-VNQTSLRRQTMAGTPYWMAPEVIM-----EGVYYDTKVDIWSLGITTYEIATGNPPY-CDVEALRAMQLIIKSKPPRL-EDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRA 278
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO38062 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDX6]) HSP 1 Score: 263.848 bits (673), Expect = 3.982e-84 Identity = 131/288 (45.49%), Postives = 191/288 (66.32%), Query Frame = 1
Query: 127 QQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLK 987
+ L+D T + V G++ DL+ + ELG G +G V +MLH P++ V AVK++R + + +Q R+L DL+ISMR + PY V YGA+ R GDVWICME++ +SL YK V + + IPE +L I +V+ALEYLH L+VIHRDVKPSN+L+D+ G K+CDFGISG LV+S+A+T + G + Y+APERI + G+ IRSD+WSLG++++ELA KFPY + + + V P PSLPE +S R+F+++ L+ K+R +Y +LL+H +K
Sbjct: 36 RNLSDKTTITVGGQEFDCQADDLQEIRELGHGAYGYVYEMLHVPTSTVMAVKKIRANVNSTEQKRLLMDLDISMRVSDYPYTVHFYGALFREGDVWICMELMKTSLYDLYKQVFS-KPDRRIPEEVLGKIAVSVVSALEYLHSNLKVIHRDVKPSNILVDERGNFKLCDFGISGQLVDSLAKTVDAGCKPYMAPERINPDRDMKGYDIRSDIWSLGITMIELATGKFPYTQWKTPFEQLKQVVHEPSPSLPE-GPFSLNFRDFVTKSLIKNYKERPNYNQLLEHPFIK 321
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO48408 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJN6]) HSP 1 Score: 251.521 bits (641), Expect = 6.051e-80 Identity = 123/274 (44.89%), Postives = 181/274 (66.06%), Query Frame = 1
Query: 181 SMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSY--SNTVRNFISRCLVIAVKDRASYLELLKHDLLKSF 993
S SDL E+G+G +G V +MLH SN AVK++R + D K Q ++L DL++ MRS+ CP++V YGA+ GD WICME+++ S DK YKLV E IPE +L+ + + +V AL+YL + L +IHRDVKPSN+L+D++G +K+CDFGISG LV+S+A+T + G + Y+APERI + G+ IRSDVWS G++++EL+ FPYP S+++ ++ V +G PP L S + NF++ CL V+ R Y ELL H ++ +
Sbjct: 5 SSSDLVDCGEIGRGAYGTVNKMLHPNSNTFMAVKRIRSTVDQKDQKQLLMDLDVVMRSSNCPFIVRFYGALFTEGDAWICMELMEISFDKCYKLVYG-SIEQIIPEEILSKVAYAVVKALDYLKRELNIIHRDVKPSNILLDRNGAIKLCDFGISGHLVDSIAKTRDAGCKPYMAPERIDPSSCRQGYDIRSDVWSFGITMIELSTGVFPYPKWNSVFDQLSQVVDGDPPQLSNTPEMMRSPELLNFVNICLSKEVEKRPKYNELLNHQFIQLY 277
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO43384 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYU8]) HSP 1 Score: 214.157 bits (544), Expect = 2.411e-65 Identity = 116/283 (40.99%), Postives = 173/283 (61.13%), Query Frame = 1
Query: 151 VQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTS-GFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSF 993
+++ +K S+ DLE E+G G G V +M HK S V AVK++ S + ++Q RIL DL + M+S CPY+V GA+ DV+ICME++ + LDK K + ++ IPE +L + IV AL YL + V+HRDVKPSN+L+D +G VK+CDF ISG LV+S A+T + G +Y+APERI + + + +R+DVWSLG+S++ELA +FPY + + ++T V PPSLP + +S+ +F+ CL R Y +LL H + S+
Sbjct: 29 LKLGDKKYDFSLDDLEMSGEIGYGTCGQVCKMKHKKSGQVLAVKRMARSHNKEEQKRILMDLEVVMKSHDCPYIVTCMGALISKSDVFICMELMATCLDKLLKRL-----QNPIPEHILGKMAVAIVKALHYLKEEHGVMHRDVKPSNMLLDSAGCVKLCDFSISGRLVDSKAKTKSAGCAAYMAPERIDPPDPMNPNYDVRADVWSLGISLVELATGEFPYRNCTTEFEVLTRVMGEDPPSLPGSKGFSHDFSSFVDECLTKDFHYRPKYNKLLVHPFITSY 306
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO45553 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSF4]) HSP 1 Score: 179.489 bits (454), Expect = 7.882e-52 Identity = 106/338 (31.36%), Postives = 175/338 (51.78%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDS-SLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYP-----------------------------------------LDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQNN 1065
+S D E + ELG G G+V ++LHKP+ L+ A K + + +I+ +L + + PY+V +GA + G++ ICME +D SLD K I PE +L I+ ++ L YL + ++IHRDVKPSN+L++ G +K+CDFG+SG L++S+A + +GT+SY++PER+ + +TI+SD+WS GLS++E+AI ++P P ++++ L+ Y+ PPP LP + +S F+ +CLV K RA L+ H F ++ NV +FA +++ L +
Sbjct: 34 LSNDDFEKITELGAGNGGVVTKVLHKPTGLIMARKLIHLEVKPAIRTQIIRELKV-LHDCNSPYIVGFFGAFYSDGEISICMEHMDGGSLDLILKKAGRI------PEDILGKISIAVLKGLCYLREIHQIIHRDVKPSNILVNSRGEIKMCDFGVSGQLIDSMANSFVGTRSYMSPERL----QGNQYTIQSDIWSFGLSLVEMAIGRYPIPPPDPQEIEKVLSREPSSMASPMSVGRLPPGVRPPSGVNNETRPMAIFELLDYIVNEPPPILP-GAHFSPEFCEFVQKCLVKNPKQRADLTYLMTH----KFIAKADKSNV--DFAKWISQFLSED 353
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9]) HSP 1 Score: 152.91 bits (385), Expect = 3.212e-42 Identity = 94/282 (33.33%), Postives = 157/282 (55.67%), Query Frame = 1
Query: 193 LETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDS-SLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTN--LGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNE 1029
+ L +LG+G +G V + +HK S V A+KQ+ D ++ I+ ++++ M+ PYVV YG+ + D+WI ME + S+ K+ + TE I + +L Y + LEYLH R IHRD+K N+L++ G K+ DFG++G L +++A+ N +GT ++APE I G+ +D+WSLG++ +E+A K PY DI I + PPP+ + +S ++F+S+CLV ++RA+ ELL+H ++ S L ++ E
Sbjct: 24 FDVLEKLGEGSYGSVFKAMHKESGQVVAIKQVPVDTDLQE---IIKEISM-MQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDLMKIRNKTLTEEEI-KCVLKYT----LKGLEYLH-LRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEVGYDCLADIWSLGITAMEMAEGKPPYA-DIHPMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSFIQGAKQISILSSMIQE 290
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: MAP2K6 (dual specificity mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:101170843]) HSP 1 Score: 279.641 bits (714), Expect = 6.045e-90 Identity = 143/313 (45.69%), Postives = 209/313 (66.77%), Query Frame = 1
Query: 121 PVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
P + L V + + + DLE + ELG+G +G+V++M H P+N++ AVK++R + + +Q R+L DL+ISMR+ C Y V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L I IV ALE+LH+ L VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI + + G++++SD+WSLG++++ELAILKFPY + + + V + P P LP + +S +FIS+CL A ++R +Y EL+ H SF+T ++ + + A++V IL
Sbjct: 31 PPRDLDSKACVTIGDQNFVVKADDLEQIEELGRGAYGVVDKMKHVPTNVIMAVKRIRATVNTLEQKRLLMDLDISMRTVDCHYTVTFYGALFREGDVWICMELMDTSLDKFYKNVIEKGKT--IPEDILGKIAVAIVKALEHLHRNLSVIHRDVKPSNVLINTLGQVKMCDFGISGHLVDSVAKTMDAGCKPYMAPERINPDLNQKGYSVKSDIWSLGITMIELAILKFPYDSWGTPFQQLKQVVDEPSPQLPAD-RFSPEFVDFISQCLRKAPRERPAYTELMNH----SFFT--LHDSKETDVASFVKVIL 334
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: map2k6 (dual specificity mitogen-activated protein kinase kinase 6 [Source:NCBI gene;Acc:101163933]) HSP 1 Score: 280.411 bits (716), Expect = 6.329e-90 Identity = 149/342 (43.57%), Postives = 211/342 (61.70%), Query Frame = 1
Query: 40 SSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQN 1062
KKKP L + E P + L V + +K + DLE + ELG+G +G+V++M H PS L+ AVK++R + + ++Q R+L DL+ISMR+ C Y V YGA+ R GDVWICME++D+SLDKFYK V G IPE +L I IV ALE+LH L+VIHRDVKPSNVLI+ G+VK+CDFGISG LV+SVA+T + G + Y+APERI E + G+ ++SD+WSLG++++ELAIL+FPY + + + V E P P LP +S +F S+CL K+R +Y EL++H S + + + A++V IL +
Sbjct: 30 GGKKKP----VLKLSKEVFEQPAPAAVPPRDLDSKACVTIGEKKCEVKADDLEQICELGRGAYGVVDKMRHVPSGLIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVIEKGLT--IPEDILGKIAVSIVKALEHLHSNLQVIHRDVKPSNVLINTQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYESWGTPFQQLKQVVEEPSPQLPAG-QFSPEFVDFTSQCLRKVSKERPTYTELMQHPFFTSHDAK------ETDVASFVKVILGD 358
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: map2k4b (dual specificity mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:101161098]) HSP 1 Score: 264.233 bits (674), Expect = 5.990e-83 Identity = 132/296 (44.59%), Postives = 193/296 (65.20%), Query Frame = 1
Query: 178 ISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
+ DL L E+G+G +G V +M+HKP+ + AVK++R + ++K+Q ++L DL++ MRS+ C Y+V YGA+ R GD WICME++ +SLDKFYK V + IPE +L IT V AL +L + L++IHRD+KPSN+L+D+ G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V +G PP L E +S NF++ CL R Y ELLKH + Y + F+ + A+YV IL
Sbjct: 105 FTAEDLRDLGEIGRGAYGSVNKMVHKPTGQIMAVKRIRSTVEEKEQKQLLMDLDVVMRSSDCLYIVQFYGALFREGDCWICMELMSTSLDKFYKYVYC-ALDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILMDRRGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGEPPQLSNSEERQFSPKFINFVNLCLTKDESKRPKYRELLKHSFI-LMYEERFV-----DVASYVCRIL 393
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: map2k4a (mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:101174917]) HSP 1 Score: 264.233 bits (674), Expect = 6.532e-83 Identity = 134/323 (41.49%), Postives = 208/323 (64.40%), Query Frame = 1
Query: 118 NP-VQQLTDHT-----EVQVNGEK-ITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
NP +++L H+ +++++ E+ + DL+ L E+G+G +G V +M+HKPSN + AVK++R + D+K+Q ++L DL++ +RS+ CPY+V YGA+ R GD WICME++ +SLDKFYK V + IPE +L IT V AL +L + L++IHRD+KPSN+L+D+ G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V G PP L + +S +F++ CL R Y ELL+ ++ + +S + A YV I+
Sbjct: 88 NPHIERLRTHSIESSGKLKISAEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSNQIMAVKRIRSTVDEKEQKQLLMDLDVVVRSSDCPYIVQFYGALFREGDCWICMELMATSLDKFYKFVYC-SLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVRGDPPQLSNSDERRFSPKFISFVNVCLTKEESKRPKYRELLRDPFIQMYEERSV------DVAGYVCRIM 403
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Match: map2k4a (mitogen-activated protein kinase kinase 4 [Source:NCBI gene;Acc:101174917]) HSP 1 Score: 263.848 bits (673), Expect = 8.069e-83 Identity = 134/323 (41.49%), Postives = 208/323 (64.40%), Query Frame = 1
Query: 118 NP-VQQLTDHT-----EVQVNGEK-ITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSL--PENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
NP +++L H+ +++++ E+ + DL+ L E+G+G +G V +M+HKPSN + AVK++R + D+K+Q ++L DL++ +RS+ CPY+V YGA+ R GD WICME++ +SLDKFYK V + IPE +L IT V AL +L + L++IHRD+KPSN+L+D+ G +K+CDFGISG LV+S+A+T + G + Y+APERI S G+ +RSDVWSLG+++ ELA +FPYP S+++ +T V G PP L + +S +F++ CL R Y ELL+ ++ + +S + A YV I+
Sbjct: 82 NPHIERLRTHSIESSGKLKISAEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSNQIMAVKRIRSTVDEKEQKQLLMDLDVVVRSSDCPYIVQFYGALFREGDCWICMELMATSLDKFYKFVYC-SLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVRGDPPQLSNSDERRFSPKFISFVNVCLTKEESKRPKYRELLRDPFIQMYEERSV------DVAGYVCRIM 397
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000040748.1 (SMESG000040748.1) HSP 1 Score: 710.679 bits (1833), Expect = 0.000e+0 Identity = 344/344 (100.00%), Postives = 344/344 (100.00%), Query Frame = 1
Query: 34 MASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQNN 1065
MASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQNN
Sbjct: 1 MASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFILQNN 344
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000041446.1 (SMESG000041446.1) HSP 1 Score: 422.935 bits (1086), Expect = 7.788e-146 Identity = 204/348 (58.62%), Postives = 262/348 (75.29%), Query Frame = 1
Query: 46 KKKPPNFKTFNLKSGI----------IEPVLINDNPVQQLTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYN-LITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLKSFYTQSFLENVQNEFANYVTFIL 1056
K +PP F+ + G I+PV + V L+DHTEVQVNG KIT+++ D+E+ +GQ+G+VE+M HKPS+L+FAVK++RCS +DK+Q R+LNDLNISMRST+CPYVV+SYGAM +GGDVWICME+LDSSLDKFY + ++FIPE +LAYITFC+VTALEYLH+ L VIHRDVKPSN LIDK GRVKVCDFGISG L+NS+A+TN+G+Q YLAPERI + S SG++IRSDVWSLGLS+LELAI KFPY SL++ L V PP+LP +S+YSNTVR+FIS+CL+ DRASY L++H++L F + +L+ + FA Y T +L
Sbjct: 13 KNRPPAFRNLISEPGTDSPTTPQTESIQPVALTGKAVASLSDHTEVQVNGNKITVAIKDMES-----EGQYGVVEKMRHKPSSLIFAVKKIRCSMNDKEQRRLLNDLNISMRSTKCPYVVISYGAMFQGGDVWICMELLDSSLDKFYHKIKDKDPKAFIPERLLAYITFCLVTALEYLHRELHVIHRDVKPSNTLIDKRGRVKVCDFGISGDLINSMAKTNIGSQPYLAPERINPDPSGSGYSIRSDVWSLGLSVLELAICKFPYSRWNSLFDQLKDVVASDTPPALPNDSTYSNTVRHFISQCLIKKDSDRASYDVLIEHEMLTPFKNEKYLQESKTRFAEYATDVL 355
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000057661.1 (SMESG000057661.1) HSP 1 Score: 260.381 bits (664), Expect = 1.864e-82 Identity = 125/263 (47.53%), Postives = 179/263 (68.06%), Query Frame = 1
Query: 190 DLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQT-NLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKH 975
DL+ L E+G+G +G V +M+H+ ++ + AVK++R + D+ +Q LNDL++ M+S CP++V YGA+ R GD WICME++ +SLDKFY+ V E IPE +L + V AL+YL LRVIHRDVKPSNVLID+ G +K+CDFGISG L++S+A++ + G + Y+APERI + S G+ IRSDVWSLG++++EL KFPYP S++ +T V G PPS+ ++ +S +NFI RCL R Y EL +H
Sbjct: 53 DLQDLGEIGRGAYGSVNRMIHRKTDQLMAVKRIRSTLDESQQYSTLNDLDVIMKSANCPFIVRFYGALFREGDCWICMELMSTSLDKFYRYVYVHLKEK-IPEKILGKVAVGTVKALDYLKVELRVIHRDVKPSNVLIDRDGNIKLCDFGISGQLIDSIAKSRDAGCKPYMAPERIHPKLSAKGYDIRSDVWSLGITMIELGTGKFPYPAWESVFEQLTCVLHGDPPSVNDSMGFSRQFQNFIERCLEKDYSKRPRYDELKQH 314
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000035167.1 (SMESG000035167.1) HSP 1 Score: 193.741 bits (491), Expect = 2.990e-57 Identity = 114/300 (38.00%), Postives = 174/300 (58.00%), Query Frame = 1
Query: 133 LTDHTEVQVNGEKITISMSDLETLNELGKGQFGIVEQMLHKPSNLVFAVKQLRCSKDDKKQDRILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNLGTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFIS--RC-LVIAVKDRASYLELLKHDLLKSFYTQSFLENVQ 1023
L++ + + E I M +L + LG+G F V+ M + + FAVK D+ +D I+ND+ + +S P+ + YG + +WI ME +D S+ FY+ + + + P ++L Y ++C V LE LH +VIHRDVKPSN+LI++SG+ K+CDFGISG L +S+ Q+ +GT +YLAPE+I ++ ++I SDVWSLGLSILE+A +KFP+ +L + + + + PP+LP +S Y + I +C LV K R Y +L K LL+SF QS Q
Sbjct: 11 LSNRLQCRYKNEDSYIEMDNLLFIKHLGEGNFSTVQLMKDPVTEIEFAVKMFNNVADNVMKD-IMNDIEVG-KSISSPFKIDYYGGLKDPYRIWILMEPMDLSVRLFYEKIISKDKDYRFPGIILGYFSYCSVYVLEDLHLK-QVIHRDVKPSNMLINRSGKFKLCDFGISGKLKDSLVQSAVGTNAYLAPEKIDPKSHGDKYSIISDVWSLGLSILEIADMKFPFSNCKTLMSQLYNIVQSSPPTLPLDSPYHKQYPDLIKFFQCTLVKDPKQRYRYDKLKKLPLLQSFSDQSKFNEAQ 307
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Match: SMESG000007331.1 (SMESG000007331.1) HSP 1 Score: 195.282 bits (495), Expect = 4.580e-55 Identity = 107/282 (37.94%), Postives = 163/282 (57.80%), Query Frame = 1
Query: 151 VQVNGEKITISMSDLETLNELGKGQFGIVEQM-LHKPSNLVFAVKQLRCSKDDKKQD-RILNDLNISMRSTQCPYVVVSYGAMHRGGDVWICMEILDSSLDKFYKLVSAIGTESFIPEMMLAYITFCIVTALEYLHQALRVIHRDVKPSNVLIDKSGRVKVCDFGISGTLVNSVAQTNL-GTQSYLAPERIITENSTSGFTIRSDVWSLGLSILELAILKFPYPLDISLYNLITYVTEGPPPSLPENSSYSNTVRNFISRCLVIAVKDRASYLELLKHDLLK 987
+ +N EKIT M + E + LG G G V +M L + ++ AVKQ+R S +++ RI DL++ R CP++V YG +VWICME + + LDK K ++ PE ++ ++ I+ AL+YL ++HRD+KPSN+L+ G VK+CDFGIS L +S+A + G Y+APER+ ++S + +R+DVWSLG+S++ELAI KFP S + ++ + +G PPSLPE YS F+S CL +R Y +L+ D +
Sbjct: 59 LTINNEKITTKMDEFEIESSLGHGTCGNVYRMRLKRLPSIPMAVKQMRRSSHSVEENKRIFRDLDVVTRCHDCPFIVTCYGIFISPSEVWICMEEMSTCLDKLLKFLNCP-----FPEYVIGKVSCAIIKALQYLKTKHDIMHRDIKPSNMLLSDRGEVKLCDFGISAKLKDSIANSRQPGCIGYMAPERL----NSSTYDVRADVWSLGMSLVELAIGKFPIDGLKSEFEIMARIIDGKPPSLPE-GVYSEAFNKFVSSCLQKDFNNRPKYDKLVSADFYR 330 The following BLAST results are available for this feature:
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Dual specificity mitogen-activated protein kinase kinase 6 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017135 ID=SMED30017135|Name=Dual specificity mitogen-activated protein kinase kinase 6|organism=Schmidtea mediterranea sexual|type=transcript|length=1539bpback to top protein sequence of SMED30017135-orf-1 >SMED30017135-orf-1 ID=SMED30017135-orf-1|Name=SMED30017135-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=345bp MASSKKKPPNFKTFNLKSGIIEPVLINDNPVQQLTDHTEVQVNGEKITISback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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