Tyrosine-protein kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017128 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: FYN (FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037]) HSP 1 Score: 420.239 bits (1079), Expect = 5.539e-138 Identity = 211/451 (46.78%), Postives = 294/451 (65.19%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY+Y DL+F KG+ + + WW A +TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY++ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV + L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +M+ CW E+RPTF +L+ E+Y ATE QY
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE---EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQY 531 HSP 2 Score: 65.855 bits (159), Expect = 1.874e-10 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: FYN (FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037]) HSP 1 Score: 420.239 bits (1079), Expect = 5.539e-138 Identity = 211/451 (46.78%), Postives = 294/451 (65.19%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY+Y DL+F KG+ + + WW A +TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY++ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV + L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +M+ CW E+RPTF +L+ E+Y ATE QY
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE---EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQY 531 HSP 2 Score: 65.855 bits (159), Expect = 1.874e-10 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: HCK (HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840]) HSP 1 Score: 418.698 bits (1075), Expect = 7.203e-138 Identity = 218/451 (48.34%), Postives = 294/451 (65.19%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP-FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V ALY+Y + DL+F KGD MVV + E WW A + GYIPSNYV+ D T E WF I +A+R+LL GN G+++IR S ++ +LS+R +DP R VKHYKIRTLDNGG+YIS R+ F ++ L+ HY + DGLC +L+ P + + P++ E+ R+ + L +KLG G FGEVW+ +N +VAVK M+P M + FL EA +M L H ++V++ V T+ PIYIITE MAKG+LL+FL+ +EG K L ++ +QIAEGMA++E + ++HRDLRAANILVS L K+ADFGLAR+ ED EY A G KFPIKWTAPEA F++KSDVWSFG+L+ EI+TYGR PY G N +V+ + RGYR+P P+ CP ELYNIM+ CW E+RPTF +++ +++ ATE QY
Sbjct: 61 VVALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEGYIPSNYVARVDSLET--EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDP-RQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTK---EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEN----CPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQY 500 HSP 2 Score: 63.5438 bits (153), Expect = 9.384e-10 Identity = 44/111 (39.64%), Postives = 58/111 (52.25%), Query Frame = 2
Query: 320 VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSSDCAIKTSWEIV*KDPPQ 649
V ALY Y+ + DLSF KGD + V + WW AR T GYIPSNYV D T E FF+ I+ +A+++LL G G+++IR S S + DP Q
Sbjct: 61 VVALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEGYIPSNYVARVDSLETE-EWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQ 169
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: HCK (HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840]) HSP 1 Score: 418.313 bits (1074), Expect = 8.647e-138 Identity = 218/451 (48.34%), Postives = 294/451 (65.19%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP-FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V ALY+Y + DL+F KGD MVV + E WW A + GYIPSNYV+ D T E WF I +A+R+LL GN G+++IR S ++ +LS+R +DP R VKHYKIRTLDNGG+YIS R+ F ++ L+ HY + DGLC +L+ P + + P++ E+ R+ + L +KLG G FGEVW+ +N +VAVK M+P M + FL EA +M L H ++V++ V T+ PIYIITE MAKG+LL+FL+ +EG K L ++ +QIAEGMA++E + ++HRDLRAANILVS L K+ADFGLAR+ ED EY A G KFPIKWTAPEA F++KSDVWSFG+L+ EI+TYGR PY G N +V+ + RGYR+P P+ CP ELYNIM+ CW E+RPTF +++ +++ ATE QY
Sbjct: 62 VVALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEGYIPSNYVARVDSLET--EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDP-RQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTK---EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEN----CPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQY 501 HSP 2 Score: 63.5438 bits (153), Expect = 8.184e-10 Identity = 44/111 (39.64%), Postives = 58/111 (52.25%), Query Frame = 2
Query: 320 VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSSDCAIKTSWEIV*KDPPQ 649
V ALY Y+ + DLSF KGD + V + WW AR T GYIPSNYV D T E FF+ I+ +A+++LL G G+++IR S S + DP Q
Sbjct: 62 VVALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEGYIPSNYVARVDSLETE-EWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQ 170
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: HCK (HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840]) HSP 1 Score: 418.313 bits (1074), Expect = 8.647e-138 Identity = 218/451 (48.34%), Postives = 294/451 (65.19%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP-FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V ALY+Y + DL+F KGD MVV + E WW A + GYIPSNYV+ D T E WF I +A+R+LL GN G+++IR S ++ +LS+R +DP R VKHYKIRTLDNGG+YIS R+ F ++ L+ HY + DGLC +L+ P + + P++ E+ R+ + L +KLG G FGEVW+ +N +VAVK M+P M + FL EA +M L H ++V++ V T+ PIYIITE MAKG+LL+FL+ +EG K L ++ +QIAEGMA++E + ++HRDLRAANILVS L K+ADFGLAR+ ED EY A G KFPIKWTAPEA F++KSDVWSFG+L+ EI+TYGR PY G N +V+ + RGYR+P P+ CP ELYNIM+ CW E+RPTF +++ +++ ATE QY
Sbjct: 62 VVALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEGYIPSNYVARVDSLET--EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDP-RQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTK---EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEN----CPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQY 501 HSP 2 Score: 63.5438 bits (153), Expect = 8.184e-10 Identity = 44/111 (39.64%), Postives = 58/111 (52.25%), Query Frame = 2
Query: 320 VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSSDCAIKTSWEIV*KDPPQ 649
V ALY Y+ + DLSF KGD + V + WW AR T GYIPSNYV D T E FF+ I+ +A+++LL G G+++IR S S + DP Q
Sbjct: 62 VVALYDYEAIHHEDLSFQKGDQMVVLEESGE-WWKARSLATRKEGYIPSNYVARVDSLETE-EWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQ 170
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 390.193 bits (1001), Expect = 1.032e-127 Identity = 212/461 (45.99%), Postives = 289/461 (62.69%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRP-SSDSRNCALSIRHFDPERNFYVVKHYKIRTLD-NGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPR--QHKPPFQF---REIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLS----VKVADFGLAR--ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELY-NIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYG 2082
ALY Y+ GDL+F KGD M + N WW+ HQ QTGY+P N+V+ + E W+ I + A+R +L PKGT++IR +D+R AL+IR D +RN VKHYKI+ LD + GY+I+ R F ++ L+ +Y+ DGLCC+LT P PR +P + E+ R + L RKLG+G+FGEVW GKW I+EVA+K M+P M + FL EAQ+M + HP +V++ VCT P YIITE M G+LL +LR + G L +Q ++ M +QIA GM YLE + VHRDL A N+LV D +S VKVADFGLAR + ED Y A G KFPIKWTAPEA F+VKSDVWS+G+L++EI+T G+ PY G N +V+E+V GYR+P P+G CP ++Y ++L CWD T ++RPTF L F++Y ++T+ Y
Sbjct: 22 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTRE--EPFYIITEYMINGSLLQYLRTD-GSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNYA 473 HSP 2 Score: 65.0846 bits (157), Expect = 9.287e-11 Identity = 33/88 (37.50%), Postives = 46/88 (52.27%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIR 589
ALY YD R GDLSF KGD +++ + N WW RH RT GY+P N+V + +I A++ +L GT++IR
Sbjct: 22 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIR 109
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 390.578 bits (1002), Expect = 4.831e-127 Identity = 212/461 (45.99%), Postives = 289/461 (62.69%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRP-SSDSRNCALSIRHFDPERNFYVVKHYKIRTLD-NGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPR--QHKPPFQF---REIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLS----VKVADFGLAR--ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELY-NIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYG 2082
ALY Y+ GDL+F KGD M + N WW+ HQ QTGY+P N+V+ + E W+ I + A+R +L PKGT++IR +D+R AL+IR D +RN VKHYKI+ LD + GY+I+ R F ++ L+ +Y+ DGLCC+LT P PR +P + E+ R + L RKLG+G+FGEVW GKW I+EVA+K M+P M + FL EAQ+M + HP +V++ VCT P YIITE M G+LL +LR + G L +Q ++ M +QIA GM YLE + VHRDL A N+LV D +S VKVADFGLAR + ED Y A G KFPIKWTAPEA F+VKSDVWS+G+L++EI+T G+ PY G N +V+E+V GYR+P P+G CP ++Y ++L CWD T ++RPTF L F++Y ++T+ Y
Sbjct: 78 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTRE--EPFYIITEYMINGSLLQYLRTD-GSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNYA 529 HSP 2 Score: 65.4698 bits (158), Expect = 9.596e-11 Identity = 33/88 (37.50%), Postives = 46/88 (52.27%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIR 589
ALY YD R GDLSF KGD +++ + N WW RH RT GY+P N+V + +I A++ +L GT++IR
Sbjct: 78 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIR 165
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 390.578 bits (1002), Expect = 4.831e-127 Identity = 212/461 (45.99%), Postives = 289/461 (62.69%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRP-SSDSRNCALSIRHFDPERNFYVVKHYKIRTLD-NGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPR--QHKPPFQF---REIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLS----VKVADFGLAR--ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELY-NIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYG 2082
ALY Y+ GDL+F KGD M + N WW+ HQ QTGY+P N+V+ + E W+ I + A+R +L PKGT++IR +D+R AL+IR D +RN VKHYKI+ LD + GY+I+ R F ++ L+ +Y+ DGLCC+LT P PR +P + E+ R + L RKLG+G+FGEVW GKW I+EVA+K M+P M + FL EAQ+M + HP +V++ VCT P YIITE M G+LL +LR + G L +Q ++ M +QIA GM YLE + VHRDL A N+LV D +S VKVADFGLAR + ED Y A G KFPIKWTAPEA F+VKSDVWS+G+L++EI+T G+ PY G N +V+E+V GYR+P P+G CP ++Y ++L CWD T ++RPTF L F++Y ++T+ Y
Sbjct: 78 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTRE--EPFYIITEYMINGSLLQYLRTD-GSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNYA 529 HSP 2 Score: 65.4698 bits (158), Expect = 9.596e-11 Identity = 33/88 (37.50%), Postives = 46/88 (52.27%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIR 589
ALY YD R GDLSF KGD +++ + N WW RH RT GY+P N+V + +I A++ +L GT++IR
Sbjct: 78 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIR 165
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 390.578 bits (1002), Expect = 4.913e-127 Identity = 212/461 (45.99%), Postives = 289/461 (62.69%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRP-SSDSRNCALSIRHFDPERNFYVVKHYKIRTLD-NGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPR--QHKPPFQF---REIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLS----VKVADFGLAR--ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELY-NIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYG 2082
ALY Y+ GDL+F KGD M + N WW+ HQ QTGY+P N+V+ + E W+ I + A+R +L PKGT++IR +D+R AL+IR D +RN VKHYKI+ LD + GY+I+ R F ++ L+ +Y+ DGLCC+LT P PR +P + E+ R + L RKLG+G+FGEVW GKW I+EVA+K M+P M + FL EAQ+M + HP +V++ VCT P YIITE M G+LL +LR + G L +Q ++ M +QIA GM YLE + VHRDL A N+LV D +S VKVADFGLAR + ED Y A G KFPIKWTAPEA F+VKSDVWS+G+L++EI+T G+ PY G N +V+E+V GYR+P P+G CP ++Y ++L CWD T ++RPTF L F++Y ++T+ Y
Sbjct: 82 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTRE--EPFYIITEYMINGSLLQYLRTD-GSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNYA 533 HSP 2 Score: 65.4698 bits (158), Expect = 9.499e-11 Identity = 33/88 (37.50%), Postives = 46/88 (52.27%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIR 589
ALY YD R GDLSF KGD +++ + N WW RH RT GY+P N+V + +I A++ +L GT++IR
Sbjct: 82 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIR 169
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 390.578 bits (1002), Expect = 4.913e-127 Identity = 212/461 (45.99%), Postives = 289/461 (62.69%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRP-SSDSRNCALSIRHFDPERNFYVVKHYKIRTLD-NGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPR--QHKPPFQF---REIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLS----VKVADFGLAR--ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELY-NIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYG 2082
ALY Y+ GDL+F KGD M + N WW+ HQ QTGY+P N+V+ + E W+ I + A+R +L PKGT++IR +D+R AL+IR D +RN VKHYKI+ LD + GY+I+ R F ++ L+ +Y+ DGLCC+LT P PR +P + E+ R + L RKLG+G+FGEVW GKW I+EVA+K M+P M + FL EAQ+M + HP +V++ VCT P YIITE M G+LL +LR + G L +Q ++ M +QIA GM YLE + VHRDL A N+LV D +S VKVADFGLAR + ED Y A G KFPIKWTAPEA F+VKSDVWS+G+L++EI+T G+ PY G N +V+E+V GYR+P P+G CP ++Y ++L CWD T ++RPTF L F++Y ++T+ Y
Sbjct: 82 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIES--EEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTRE--EPFYIITEYMINGSLLQYLRTD-GSTLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRG----CPEQIYEEVLLKCWDKTPDRRPTFDTLYHFFDDYFVSTQPNYA 533 HSP 2 Score: 65.4698 bits (158), Expect = 9.499e-11 Identity = 33/88 (37.50%), Postives = 46/88 (52.27%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIR 589
ALY YD R GDLSF KGD +++ + N WW RH RT GY+P N+V + +I A++ +L GT++IR
Sbjct: 82 ALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIR 169
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0100508) HSP 1 Score: 389.423 bits (999), Expect = 2.561e-126 Identity = 201/472 (42.58%), Postives = 293/472 (62.08%), Query Frame = 1
Query: 700 TIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREI--------EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLAR-ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
T P V V ALY+Y + DL+F KGD M V D WW + Q G IP N+V+ + + E WF +++ EAD+ LL NP+GT+++RPS + N +LS++ ++ R ++V KHY+I+ LDNGGYYI+ FP ++ L+ Y+++ GLC L+ P P KP Q ++ E+ R I L+RKLG G+FGEV+ GKW + I+VAVK +R M + FL EA +M K H R+V + VC++ PIYI+ E M+KG+LL+FLRE +G+ L +D++ + +Q+A GM YLESK +HRDL A N+L+ ++ K+ DFGLAR I +DEY G++FP+KWTAPEA + FS+KSDVWS+G+L+ E+ TYG+ PY G + +V+E + RG+R+P P P +Y ++L CWDA EKRPTF FL FE++++ +E Y
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSV--NSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHV-KHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE--EPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF--PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 547 HSP 2 Score: 62.3882 bits (150), Expect = 1.180e-9 Identity = 42/108 (38.89%), Postives = 56/108 (51.85%), Query Frame = 2
Query: 284 TVPNSSPNLGVK--VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
T P P + +K V ALY Y R+ DLSF KGD + V + WW + T G IP N+ V ++ S S + FFE + EADK LL GT+++RPS
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNF-VAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSE 192
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0100505) HSP 1 Score: 389.423 bits (999), Expect = 2.561e-126 Identity = 201/472 (42.58%), Postives = 293/472 (62.08%), Query Frame = 1
Query: 700 TIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREI--------EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLAR-ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
T P V V ALY+Y + DL+F KGD M V D WW + Q G IP N+V+ + + E WF +++ EAD+ LL NP+GT+++RPS + N +LS++ ++ R ++V KHY+I+ LDNGGYYI+ FP ++ L+ Y+++ GLC L+ P P KP Q ++ E+ R I L+RKLG G+FGEV+ GKW + I+VAVK +R M + FL EA +M K H R+V + VC++ PIYI+ E M+KG+LL+FLRE +G+ L +D++ + +Q+A GM YLESK +HRDL A N+L+ ++ K+ DFGLAR I +DEY G++FP+KWTAPEA + FS+KSDVWS+G+L+ E+ TYG+ PY G + +V+E + RG+R+P P P +Y ++L CWDA EKRPTF FL FE++++ +E Y
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSV--NSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHV-KHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE--EPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF--PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 547 HSP 2 Score: 62.3882 bits (150), Expect = 1.180e-9 Identity = 42/108 (38.89%), Postives = 56/108 (51.85%), Query Frame = 2
Query: 284 TVPNSSPNLGVK--VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
T P P + +K V ALY Y R+ DLSF KGD + V + WW + T G IP N+ V ++ S S + FFE + EADK LL GT+++RPS
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNF-VAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSE 192
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0100504) HSP 1 Score: 389.423 bits (999), Expect = 2.561e-126 Identity = 201/472 (42.58%), Postives = 293/472 (62.08%), Query Frame = 1
Query: 700 TIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREI--------EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLAR-ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
T P V V ALY+Y + DL+F KGD M V D WW + Q G IP N+V+ + + E WF +++ EAD+ LL NP+GT+++RPS + N +LS++ ++ R ++V KHY+I+ LDNGGYYI+ FP ++ L+ Y+++ GLC L+ P P KP Q ++ E+ R I L+RKLG G+FGEV+ GKW + I+VAVK +R M + FL EA +M K H R+V + VC++ PIYI+ E M+KG+LL+FLRE +G+ L +D++ + +Q+A GM YLESK +HRDL A N+L+ ++ K+ DFGLAR I +DEY G++FP+KWTAPEA + FS+KSDVWS+G+L+ E+ TYG+ PY G + +V+E + RG+R+P P P +Y ++L CWDA EKRPTF FL FE++++ +E Y
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSV--NSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHV-KHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE--EPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF--PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 547 HSP 2 Score: 62.3882 bits (150), Expect = 1.180e-9 Identity = 42/108 (38.89%), Postives = 56/108 (51.85%), Query Frame = 2
Query: 284 TVPNSSPNLGVK--VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
T P P + +K V ALY Y R+ DLSF KGD + V + WW + T G IP N+ V ++ S S + FFE + EADK LL GT+++RPS
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNF-VAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSE 192
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0304990) HSP 1 Score: 389.423 bits (999), Expect = 2.561e-126 Identity = 201/472 (42.58%), Postives = 293/472 (62.08%), Query Frame = 1
Query: 700 TIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREI--------EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLAR-ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
T P V V ALY+Y + DL+F KGD M V D WW + Q G IP N+V+ + + E WF +++ EAD+ LL NP+GT+++RPS + N +LS++ ++ R ++V KHY+I+ LDNGGYYI+ FP ++ L+ Y+++ GLC L+ P P KP Q ++ E+ R I L+RKLG G+FGEV+ GKW + I+VAVK +R M + FL EA +M K H R+V + VC++ PIYI+ E M+KG+LL+FLRE +G+ L +D++ + +Q+A GM YLESK +HRDL A N+L+ ++ K+ DFGLAR I +DEY G++FP+KWTAPEA + FS+KSDVWS+G+L+ E+ TYG+ PY G + +V+E + RG+R+P P P +Y ++L CWDA EKRPTF FL FE++++ +E Y
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSV--NSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHV-KHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE--EPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF--PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 547 HSP 2 Score: 62.3882 bits (150), Expect = 1.180e-9 Identity = 42/108 (38.89%), Postives = 56/108 (51.85%), Query Frame = 2
Query: 284 TVPNSSPNLGVK--VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
T P P + +K V ALY Y R+ DLSF KGD + V + WW + T G IP N+ V ++ S S + FFE + EADK LL GT+++RPS
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNF-VAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSE 192
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Src64B (gene:FBgn0262733 transcript:FBtr0304989) HSP 1 Score: 389.423 bits (999), Expect = 2.561e-126 Identity = 201/472 (42.58%), Postives = 293/472 (62.08%), Query Frame = 1
Query: 700 TIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREI--------EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLAR-ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
T P V V ALY+Y + DL+F KGD M V D WW + Q G IP N+V+ + + E WF +++ EAD+ LL NP+GT+++RPS + N +LS++ ++ R ++V KHY+I+ LDNGGYYI+ FP ++ L+ Y+++ GLC L+ P P KP Q ++ E+ R I L+RKLG G+FGEV+ GKW + I+VAVK +R M + FL EA +M K H R+V + VC++ PIYI+ E M+KG+LL+FLRE +G+ L +D++ + +Q+A GM YLESK +HRDL A N+L+ ++ K+ DFGLAR I +DEY G++FP+KWTAPEA + FS+KSDVWS+G+L+ E+ TYG+ PY G + +V+E + RG+R+P P P +Y ++L CWDA EKRPTF FL FE++++ +E Y
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSV--NSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHV-KHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKNALGLCHILSRPCP---KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE--EPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF--PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 547 HSP 2 Score: 62.3882 bits (150), Expect = 1.180e-9 Identity = 42/108 (38.89%), Postives = 56/108 (51.85%), Query Frame = 2
Query: 284 TVPNSSPNLGVK--VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
T P P + +K V ALY Y R+ DLSF KGD + V + WW + T G IP N+ V ++ S S + FFE + EADK LL GT+++RPS
Sbjct: 86 TTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNF-VAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSE 192
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: fyna (FYN proto-oncogene, Src family tyrosine kinase a [Source:NCBI gene;Acc:373872]) HSP 1 Score: 422.55 bits (1085), Expect = 4.074e-139 Identity = 214/456 (46.93%), Postives = 296/456 (64.91%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y + DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSI+ +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY+ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VAVK ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV D L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +ML CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 89 ALYDYEARSEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSNGNPRGTFLIRESETTKGAYSLSIQDWDETKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVHHYSARAAGLCCRLIVPCHKGMPRLADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPSSLHELMLQCWKRDPEERPTFEYLQAFLEDYFTATEPQYQPGDN 536 HSP 2 Score: 66.2402 bits (160), Expect = 8.431e-11 Identity = 39/114 (34.21%), Postives = 59/114 (51.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSDCAIKTSWEIV*KDPPQTRAPQV 667
ALY Y+ R+ DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S K ++ + +D +T+ V
Sbjct: 89 ALYDYEARSEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSNGNPRGTFLIRESE--TTKGAYSLSIQDWDETKGDHV 200
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: fynb (FYN proto-oncogene, Src family tyrosine kinase b [Source:NCBI gene;Acc:574422]) HSP 1 Score: 421.394 bits (1082), Expect = 1.309e-138 Identity = 212/456 (46.49%), Postives = 295/456 (64.69%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSIR +D + +V KHYKIR LD+GGYYI+ R F ++ L+ HYT+ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV D L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+ PQ CP L+ +M+ CW +E+RPTF +L+ E+Y ATE QY D+
Sbjct: 96 ALYDYEARTEDDLSFRKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTFLIRESETTKGAFSLSIRDWDDVKGDHV-KHYKIRKLDSGGYYITTRAQFETLQQLVQHYTERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEYMGKGSLLDFLKDGEGRALKLPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQ----DCPSSLHELMVQCWKKDAEERPTFEYLQAFLEDYFTATEPQYQPGDN 543 HSP 2 Score: 65.4698 bits (158), Expect = 1.473e-10 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S
Sbjct: 96 ALYDYEARTEDDLSFRKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTFLIRESE 186
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: fynb (FYN proto-oncogene, Src family tyrosine kinase b [Source:NCBI gene;Acc:574422]) HSP 1 Score: 421.394 bits (1082), Expect = 1.309e-138 Identity = 212/456 (46.49%), Postives = 295/456 (64.69%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSIR +D + +V KHYKIR LD+GGYYI+ R F ++ L+ HYT+ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV D L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+ PQ CP L+ +M+ CW +E+RPTF +L+ E+Y ATE QY D+
Sbjct: 96 ALYDYEARTEDDLSFRKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTFLIRESETTKGAFSLSIRDWDDVKGDHV-KHYKIRKLDSGGYYITTRAQFETLQQLVQHYTERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEYMGKGSLLDFLKDGEGRALKLPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQ----DCPSSLHELMVQCWKKDAEERPTFEYLQAFLEDYFTATEPQYQPGDN 543 HSP 2 Score: 65.4698 bits (158), Expect = 1.473e-10 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S
Sbjct: 96 ALYDYEARTEDDLSFRKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTFLIRESE 186
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: yrk (Yes-related kinase [Source:ZFIN;Acc:ZDB-GENE-030131-9517]) HSP 1 Score: 417.542 bits (1072), Expect = 2.717e-137 Identity = 212/451 (47.01%), Postives = 292/451 (64.75%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLT----EPFPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY Y+ DL+F KG+ + ++ WW A ++GYIPSNYV+ D + + +A+R+LL NP+GT++IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ RT F ++ L+ HYT+ GLCCRL P+ + +++ E+ R+ + L++KLGNG FGEVW+G WN +VAVK ++P M + FL EAQ+M +L H ++VQ+ V +E PIYIITE M++G+LL+FL++ +G+ L L ++ M +QIA GMAY+E ++HRDLRAANILV D L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E+IT GR PY G N +VLE+V RGYR+P PQG P L+ +ML CW ++R TF +L+ E+Y ATE QY
Sbjct: 80 ALYEYDARTEDDLSFQKGEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLAQNNPRGTFLIRESETTKGAYSLSIRDWDDAKGDHV-KHYKIRKLDNGGYYITTRTQFDTVQQLVEHYTERAAGLCCRLIGSCRRGMPKLADLSVKTKDVWEIPRESLQLIKKLGNGQFGEVWMGMWNGTTKVAVKTLKPGTMSPEAFLDEAQIMKRLRHDKLVQLYAVVSE---EPIYIITEFMSQGSLLDFLKDGDGRNLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDGLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCPQG----SPASLHELMLQCWRKDPDERHTFEYLQSFLEDYFTATEPQY 522 HSP 2 Score: 68.1662 bits (165), Expect = 2.440e-11 Identity = 36/91 (39.56%), Postives = 47/91 (51.65%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY YD R DLSF KG+ + +N WW AR T GYIPSNYV D F ++ +A+++LL GT++IR S
Sbjct: 80 ALYEYDARTEDDLSFQKGEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLAQNNPRGTFLIRESE 170
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: yrk (Yes-related kinase [Source:ZFIN;Acc:ZDB-GENE-030131-9517]) HSP 1 Score: 417.542 bits (1072), Expect = 2.717e-137 Identity = 212/451 (47.01%), Postives = 292/451 (64.75%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLT----EPFPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY Y+ DL+F KG+ + ++ WW A ++GYIPSNYV+ D + + +A+R+LL NP+GT++IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ RT F ++ L+ HYT+ GLCCRL P+ + +++ E+ R+ + L++KLGNG FGEVW+G WN +VAVK ++P M + FL EAQ+M +L H ++VQ+ V +E PIYIITE M++G+LL+FL++ +G+ L L ++ M +QIA GMAY+E ++HRDLRAANILV D L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E+IT GR PY G N +VLE+V RGYR+P PQG P L+ +ML CW ++R TF +L+ E+Y ATE QY
Sbjct: 80 ALYEYDARTEDDLSFQKGEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLAQNNPRGTFLIRESETTKGAYSLSIRDWDDAKGDHV-KHYKIRKLDNGGYYITTRTQFDTVQQLVEHYTERAAGLCCRLIGSCRRGMPKLADLSVKTKDVWEIPRESLQLIKKLGNGQFGEVWMGMWNGTTKVAVKTLKPGTMSPEAFLDEAQIMKRLRHDKLVQLYAVVSE---EPIYIITEFMSQGSLLDFLKDGDGRNLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDGLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCPQG----SPASLHELMLQCWRKDPDERHTFEYLQSFLEDYFTATEPQY 522 HSP 2 Score: 68.1662 bits (165), Expect = 2.440e-11 Identity = 36/91 (39.56%), Postives = 47/91 (51.65%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY YD R DLSF KG+ + +N WW AR T GYIPSNYV D F ++ +A+++LL GT++IR S
Sbjct: 80 ALYEYDARTEDDLSFQKGEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLAQNNPRGTFLIRESE 170
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: ccdc13 (coiled-coil domain containing 13 [Source:Xenbase;Acc:XB-GENE-992948]) HSP 1 Score: 424.476 bits (1090), Expect = 2.206e-140 Identity = 214/456 (46.93%), Postives = 297/456 (65.13%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GTY+IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY++ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV + L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +ML+CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 39 ALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESETTKGAYSLSIRDWDDMKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGMKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPNSLHELMLNCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGDN 486 HSP 2 Score: 67.781 bits (164), Expect = 3.573e-11 Identity = 36/91 (39.56%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GTY+IR S
Sbjct: 39 ALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESE 129
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: ccdc13 (coiled-coil domain containing 13 [Source:Xenbase;Acc:XB-GENE-992948]) HSP 1 Score: 423.32 bits (1087), Expect = 9.357e-140 Identity = 214/456 (46.93%), Postives = 297/456 (65.13%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GTY+IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY++ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV + L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +ML+CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 50 ALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESETTKGAYSLSIRDWDDMKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGMKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPNSLHELMLNCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGDN 497 HSP 2 Score: 67.781 bits (164), Expect = 4.259e-11 Identity = 36/91 (39.56%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GTY+IR S
Sbjct: 50 ALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESE 140
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: ccdc13 (coiled-coil domain containing 13 [Source:Xenbase;Acc:XB-GENE-992948]) HSP 1 Score: 424.091 bits (1089), Expect = 1.277e-139 Identity = 214/456 (46.93%), Postives = 297/456 (65.13%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GTY+IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY++ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV + L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +ML+CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 90 ALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESETTKGAYSLSIRDWDDMKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGMKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPNSLHELMLNCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGDN 537 HSP 2 Score: 68.1662 bits (165), Expect = 3.223e-11 Identity = 36/91 (39.56%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GTY+IR S
Sbjct: 90 ALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESE 180
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161]) HSP 1 Score: 414.846 bits (1065), Expect = 1.037e-136 Identity = 218/456 (47.81%), Postives = 290/456 (63.60%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREI---EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + ++ WW A + QTGYIPSNYV+ D E W+ I EA+R LL + NP+GT+++R S ++ LS+ +D R V KHYKIR LD+GG+YI+ RT F ++ L+A+Y++H DGLC RLT P KP Q E+ R + L KLG G FGEVW+G WN VA+K ++P M + FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL+ E G+ L L ++ M +QIA GMAY+E +VHRDLRAANILV ++L KVADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E+ T GR PY G N +VL++V RGYR+P P CP L+++M CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 37 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSI--QAEEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANRGLNV-KHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCP-TAKPQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----DCPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTATEPQYQPGDN 481 HSP 2 Score: 66.6254 bits (161), Expect = 7.866e-11 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ L + +N WW+AR + GYIPSNYV D +I EA++ LL + GT+++R S
Sbjct: 37 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSIQAEEWYLGKITRREAERLLLSLENPRGTFLVRESE 127
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: cthrc1 (collagen triple helix repeat containing 1 [Source:Xenbase;Acc:XB-GENE-980161]) HSP 1 Score: 414.461 bits (1064), Expect = 1.496e-136 Identity = 218/456 (47.81%), Postives = 290/456 (63.60%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREI---EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + ++ WW A + QTGYIPSNYV+ D E W+ I EA+R LL + NP+GT+++R S ++ LS+ +D R V KHYKIR LD+GG+YI+ RT F ++ L+A+Y++H DGLC RLT P KP Q E+ R + L KLG G FGEVW+G WN VA+K ++P M + FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL+ E G+ L L ++ M +QIA GMAY+E +VHRDLRAANILV ++L KVADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E+ T GR PY G N +VL++V RGYR+P P CP L+++M CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 39 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSI--QAEEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANRGLNV-KHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCP-TAKPQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----DCPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTATEPQYQPGDN 483 HSP 2 Score: 66.6254 bits (161), Expect = 8.478e-11 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ L + +N WW+AR + GYIPSNYV D +I EA++ LL + GT+++R S
Sbjct: 39 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLARSLSSGQTGYIPSNYVAPSDSIQAEEWYLGKITRREAERLLLSLENPRGTFLVRESE 129
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Fyn (Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602]) HSP 1 Score: 421.394 bits (1082), Expect = 1.273e-138 Identity = 211/451 (46.78%), Postives = 295/451 (65.41%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY+Y DL+F KG+ + + WW A +TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY++ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV + L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +M+ CW E+RPTF +L+ E+Y ATE QY
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQY 531 HSP 2 Score: 65.855 bits (159), Expect = 1.298e-10 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Lyn (LYN proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892]) HSP 1 Score: 413.305 bits (1061), Expect = 4.076e-136 Identity = 220/452 (48.67%), Postives = 296/452 (65.49%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP--FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V ALY Y+ + DL+F KG+ M V + E WW A + + G+IPSNYV+ + T E WF DI +A+R+LL GN G ++IR S + +LS+R +DP V+KHYKIR+LDNGGYYIS R FP I +I HY + +DGLC RL + P+ KP + E+ R+ I LV+KLG G FGEVW+G +N+ +VAVK ++P M FL EA LM L H ++V++ V T+ PIYIITE MAKG+LL+FL+ +EG K+ L ++ +QIAEGMAY+E K ++HRDLRAAN+LVS+ L K+ADFGLAR+ ED EY A G KFPIKWTAPEA F++KSDVWSFG+L++EI+TYG+ PY G N V+ +S+GYR+P + CP ELY+IM CW +E+RPTF +L+ +++ ATE QY
Sbjct: 47 VVALYPYDGIHPDDLSFKKGEKMKVLEEHGE-WWKAKSLSSKREGFIPSNYVAKVNTLET--EEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDYDPMHG-DVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQSDGLCRRLEKACISPKPQKP-WDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKE--EPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMEN----CPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQY 487 HSP 2 Score: 61.2326 bits (147), Expect = 3.265e-9 Identity = 36/93 (38.71%), Postives = 51/93 (54.84%), Query Frame = 2
Query: 320 VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
V ALY YD +P DLSF KG+ + V + WW A+ + G+IPSNYV + T F +I +A+++LL G S G ++IR S
Sbjct: 47 VVALYPYDGIHPDDLSFKKGEKMKVLEEHGE-WWKAKSLSSKREGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESE 138
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Lyn (LYN proto-oncogene, Src family tyrosine kinase [Source:MGI Symbol;Acc:MGI:96892]) HSP 1 Score: 413.305 bits (1061), Expect = 7.363e-136 Identity = 220/452 (48.67%), Postives = 296/452 (65.49%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP--FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V ALY Y+ + DL+F KG+ M V + E WW A + + G+IPSNYV+ + T E WF DI +A+R+LL GN G ++IR S + +LS+R +DP V+KHYKIR+LDNGGYYIS R FP I +I HY + +DGLC RL + P+ KP + E+ R+ I LV+KLG G FGEVW+G +N+ +VAVK ++P M FL EA LM L H ++V++ V T+ PIYIITE MAKG+LL+FL+ +EG K+ L ++ +QIAEGMAY+E K ++HRDLRAAN+LVS+ L K+ADFGLAR+ ED EY A G KFPIKWTAPEA F++KSDVWSFG+L++EI+TYG+ PY G N V+ +S+GYR+P + CP ELY+IM CW +E+RPTF +L+ +++ ATE QY
Sbjct: 68 VVALYPYDGIHPDDLSFKKGEKMKVLEEHGE-WWKAKSLSSKREGFIPSNYVAKVNTLET--EEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDYDPMHG-DVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQSDGLCRRLEKACISPKPQKP-WDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKE--EPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMEN----CPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQY 508 HSP 2 Score: 61.2326 bits (147), Expect = 3.034e-9 Identity = 36/93 (38.71%), Postives = 51/93 (54.84%), Query Frame = 2
Query: 320 VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
V ALY YD +P DLSF KG+ + V + WW A+ + G+IPSNYV + T F +I +A+++LL G S G ++IR S
Sbjct: 68 VVALYPYDGIHPDDLSFKKGEKMKVLEEHGE-WWKAKSLSSKREGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESE 159
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Hck (hemopoietic cell kinase [Source:MGI Symbol;Acc:MGI:96052]) HSP 1 Score: 411.379 bits (1056), Expect = 2.818e-135 Identity = 215/452 (47.57%), Postives = 292/452 (64.60%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP--FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V ALY+Y + DL+F KGD MVV + E WW A + GYIPSNYV+ + T E WF I +A+R LL GN G+++IR S ++ +LS+R FDP+ VKHYKIRTLD+GG+YIS R+ F ++ L+ HY + DGLC +L+ P P+ KP ++ E+ R+ + + +KLG G FGEVW+ +N +VAVK M+P M + FL EA LM L H ++V++ V ++ PI+I+TE MAKG+LL+FL+ EEG K L ++ +QI+EGMA++E + ++HRDLRAANILVS L K+ADFGLARI ED EY A G KFPIKWTAPEA F++KSDVWSFG+L+ EI+TYGR PY G N +V+ + GYR+P P CP ELYNIM+ CW E+RPTF +++ +++ ATE QY
Sbjct: 60 VVALYDYEAIHREDLSFQKGDQMVVLEEAGE-WWKARSLATKKEGYIPSNYVARVNSLET--EEWFFKGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHG-DTVKHYKIRTLDSGGFYISPRSTFSSLQELVLHYKKGKDGLCQKLSVPCVSPKPQKP-WEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQ---EPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDN----CPEELYNIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQY 499 HSP 2 Score: 62.7734 bits (151), Expect = 1.064e-9 Identity = 46/125 (36.80%), Postives = 63/125 (50.40%), Query Frame = 2
Query: 227 LGMGKRHSKPPKGVKHTTSTVPNSSPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
LG +S PP V+ + T+ V ALY Y+ + DLSF KGD + V + WW AR T GYIPSNYV + T E FF+ I+ +A++ LL G G+++IR S
Sbjct: 39 LGPNNSNSMPPGFVEGSEDTI----------VVALYDYEAIHREDLSFQKGDQMVVLEEAGE-WWKARSLATKKEGYIPSNYVARVNSLETE-EWFFKGISRKDAERHLLAPGNMLGSFMIRDSE 151
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Hck (hemopoietic cell kinase [Source:MGI Symbol;Acc:MGI:96052]) HSP 1 Score: 411.379 bits (1056), Expect = 2.818e-135 Identity = 215/452 (47.57%), Postives = 292/452 (64.60%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP--FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V ALY+Y + DL+F KGD MVV + E WW A + GYIPSNYV+ + T E WF I +A+R LL GN G+++IR S ++ +LS+R FDP+ VKHYKIRTLD+GG+YIS R+ F ++ L+ HY + DGLC +L+ P P+ KP ++ E+ R+ + + +KLG G FGEVW+ +N +VAVK M+P M + FL EA LM L H ++V++ V ++ PI+I+TE MAKG+LL+FL+ EEG K L ++ +QI+EGMA++E + ++HRDLRAANILVS L K+ADFGLARI ED EY A G KFPIKWTAPEA F++KSDVWSFG+L+ EI+TYGR PY G N +V+ + GYR+P P CP ELYNIM+ CW E+RPTF +++ +++ ATE QY
Sbjct: 60 VVALYDYEAIHREDLSFQKGDQMVVLEEAGE-WWKARSLATKKEGYIPSNYVARVNSLET--EEWFFKGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHG-DTVKHYKIRTLDSGGFYISPRSTFSSLQELVLHYKKGKDGLCQKLSVPCVSPKPQKP-WEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQ---EPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDN----CPEELYNIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQY 499 HSP 2 Score: 62.7734 bits (151), Expect = 1.064e-9 Identity = 46/125 (36.80%), Postives = 63/125 (50.40%), Query Frame = 2
Query: 227 LGMGKRHSKPPKGVKHTTSTVPNSSPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
LG +S PP V+ + T+ V ALY Y+ + DLSF KGD + V + WW AR T GYIPSNYV + T E FF+ I+ +A++ LL G G+++IR S
Sbjct: 39 LGPNNSNSMPPGFVEGSEDTI----------VVALYDYEAIHREDLSFQKGDQMVVLEEAGE-WWKARSLATKKEGYIPSNYVARVNSLETE-EWFFKGISRKDAERHLLAPGNMLGSFMIRDSE 151
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P27446|FYN_XIPHE (Tyrosine-protein kinase Fyn OS=Xiphophorus helleri OX=8084 GN=fyn PE=2 SV=3) HSP 1 Score: 427.557 bits (1098), Expect = 3.765e-140 Identity = 215/456 (47.15%), Postives = 297/456 (65.13%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + WW A +GYIPSNYV+ D + + +A+R+LL GNP+GTY+IR S ++ +LSIR +D E+ +V KHYKIR LD+GGYYI+ R F ++ L+ HY+ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VAVK ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV D+L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +ML CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 89 ALYDYEARTEDDLSFRKGERFQILNSTEGDWWDARSLTTGGSGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTYLIRESETTKGAFSLSIRDWDDEKGDHV-KHYKIRKLDSGGYYITTRAQFDTLQQLVQHYSDRAAGLCCRLVVPCHKGMPRLADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPASLHELMLQCWKKDPEERPTFEYLQAFLEDYFTATEPQYQPGDN 536 HSP 2 Score: 65.855 bits (159), Expect = 8.325e-10 Identity = 36/91 (39.56%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GTY+IR S
Sbjct: 89 ALYDYEARTEDDLSFRKGERFQILNSTEGDWWDARSLTTGGSGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTYLIRESE 179
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P13406|FYN_XENLA (Tyrosine-protein kinase Fyn OS=Xenopus laevis OX=8355 GN=fyn PE=2 SV=3) HSP 1 Score: 423.705 bits (1088), Expect = 1.109e-138 Identity = 214/456 (46.93%), Postives = 297/456 (65.13%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GTY+IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY++ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV + L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +ML+CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 89 ALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESETTKGAYSLSIRDWDDMKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPISLHELMLNCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGDN 536 HSP 2 Score: 68.1662 bits (165), Expect = 1.719e-10 Identity = 36/91 (39.56%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GTY+IR S
Sbjct: 89 ALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESE 179
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|Q6EWH2|FYNA_DANRE (Tyrosine-protein kinase fyna OS=Danio rerio OX=7955 GN=fyna PE=1 SV=2) HSP 1 Score: 422.55 bits (1085), Expect = 3.075e-138 Identity = 214/456 (46.93%), Postives = 296/456 (64.91%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y + DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSI+ +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY+ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VAVK ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV D L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +ML CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 89 ALYDYEARSEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSNGNPRGTFLIRESETTKGAYSLSIQDWDETKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVHHYSARAAGLCCRLIVPCHKGMPRLADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPSSLHELMLQCWKRDPEERPTFEYLQAFLEDYFTATEPQYQPGDN 536 HSP 2 Score: 66.2402 bits (160), Expect = 6.365e-10 Identity = 39/114 (34.21%), Postives = 59/114 (51.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSDCAIKTSWEIV*KDPPQTRAPQV 667
ALY Y+ R+ DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S K ++ + +D +T+ V
Sbjct: 89 ALYDYEARSEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSNGNPRGTFLIRESE--TTKGAYSLSIQDWDETKGDHV 200
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P39688|FYN_MOUSE (Tyrosine-protein kinase Fyn OS=Mus musculus OX=10090 GN=Fyn PE=1 SV=4) HSP 1 Score: 421.394 bits (1082), Expect = 8.901e-138 Identity = 211/451 (46.78%), Postives = 295/451 (65.41%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY+Y DL+F KG+ + + WW A +TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY++ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV + L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +M+ CW E+RPTF +L+ E+Y ATE QY
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQY 531 HSP 2 Score: 65.855 bits (159), Expect = 9.079e-10 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|F1RDG9|FYNB_DANRE (Tyrosine-protein kinase fynb OS=Danio rerio OX=7955 GN=fynb PE=2 SV=1) HSP 1 Score: 421.394 bits (1082), Expect = 9.879e-138 Identity = 212/456 (46.49%), Postives = 295/456 (64.69%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSIR +D + +V KHYKIR LD+GGYYI+ R F ++ L+ HYT+ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VA+K ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV D L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+ PQ CP L+ +M+ CW +E+RPTF +L+ E+Y ATE QY D+
Sbjct: 96 ALYDYEARTEDDLSFRKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTFLIRESETTKGAFSLSIRDWDDVKGDHV-KHYKIRKLDSGGYYITTRAQFETLQQLVQHYTERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEYMGKGSLLDFLKDGEGRALKLPNLVDMAAQVAGGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQ----DCPSSLHELMVQCWKKDAEERPTFEYLQAFLEDYFTATEPQYQPGDN 543 HSP 2 Score: 65.4698 bits (158), Expect = 1.112e-9 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S
Sbjct: 96 ALYDYEARTEDDLSFRKGEKFQIINSTEGDWWDARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSTGNPRGTFLIRESE 186
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A094ZT02 (Tyrosine-protein kinase OS=Schistosoma haematobium OX=6185 GN=MS3_05644 PE=3 SV=1) HSP 1 Score: 589.726 bits (1519), Expect = 0.000e+0 Identity = 279/449 (62.14%), Postives = 343/449 (76.39%), Query Frame = 1
Query: 736 VRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDN-GGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V+VRALY+Y HN DL+F KGDIM V S +++ WWFA H +GYIPSNYV ++DG PTS +AW+DI EADRKLLL+GNPKGTY+IRPSS+++N ALS+RH+D E+N +VVKHY+IR LDN GG++IS RT FP+I+ LI +YT H DGLCCRL+ P PR ++PP QFR+ E+NR IT +RKLG G+FGEV+L KWN +EVAVKM R + D F+ EA+LMH HHPRIVQ+LGVCTEP P+YIITELM KGAL +FLR EEG KLTL D++ +++QIA GM+YLE VHRDLRAANILV D SVKV+DFGLA+I D+ ADP TKFPIKWTAPEA L+ +FS+KSDVWSFG+LM+EI+TYG TPY G + + EV +GYRLP P + CP +LYN+M CWDA E RPTF L D FEN++ TE QY
Sbjct: 115 VQVRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWFARHSDTGMSGYIPSNYVCLNDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLINYYTVHPDGLCCRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVKM-RLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHKLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKIISDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHTPEHPCPDDLYNLMRKCWDARPENRPTFRSLYDVFENWSTHTEAQY 562 HSP 2 Score: 124.405 bits (311), Expect = 6.369e-26 Identity = 58/96 (60.42%), Postives = 73/96 (76.04%), Query Frame = 2
Query: 314 VKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD 601
V+VRALY+Y N DLSF KGDI+FV S M+D WW ARHS T GYIPSNYV ++DG PTS++ +++I EAD+KLLL+G GTY+IRPSS+
Sbjct: 115 VQVRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWFARHSDTGMSGYIPSNYVCLNDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSE 210
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: C1LGZ6 (Tyrosine-protein kinase OS=Schistosoma japonicum OX=6182 GN=fyn-prov PE=2 SV=1) HSP 1 Score: 589.341 bits (1518), Expect = 0.000e+0 Identity = 279/449 (62.14%), Postives = 342/449 (76.17%), Query Frame = 1
Query: 736 VRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDN-GGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V+VRALY+Y HN DL F KGDIM V S +++ WWFA H +GYIPSNYV +DDG PTS +AW+DI EADRKLLL+GNPKGTY+IRPSS+++N ALS+RH+D E+N +VVKHY+IR LDN GG++IS RT FP+I+ L+ +YT H DGLCCRL+ P PR ++PP QFR+ E+NR IT +RKLG G+FGEV+L KWN +EVAVKM R + D F+ EA+LMH HHPRIVQ+LGVCTEP P+YIITELM KGAL +FLR EEG KLTL D++ +++QIA GM+YLE VHRDLRAANILV D SVKV+DFGLA+I D+ ADP TKFPIKWTAPEA L+ +FS+KSDVWSFG+LM+EI+TYG TPY G + + EV +GYRLP P + CP +LYN+M CWDA E RPTF L D FEN++ TE QY
Sbjct: 115 VQVRALYSYQGHNQDDLPFQKGDIMFVVSGMSDAWWFARHAETGMSGYIPSNYVCLDDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDGLCCRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVKM-RLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHKLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKIISDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHTPEHPCPDDLYNLMRKCWDARPENRPTFRSLYDVFENWSTHTEAQY 562 HSP 2 Score: 125.946 bits (315), Expect = 1.867e-26 Identity = 62/108 (57.41%), Postives = 77/108 (71.30%), Query Frame = 2
Query: 281 STV-PNSSPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD 601
STV P P V+VRALY+Y N DL F KGDI+FV S M+D WW ARH+ T GYIPSNYV +DDG PTS++ +++I EAD+KLLL+G GTY+IRPSS+
Sbjct: 103 STVSPGVQPRPLVQVRALYSYQGHNQDDLPFQKGDIMFVVSGMSDAWWFARHAETGMSGYIPSNYVCLDDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSE 210
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A430QHK8 (Tyrosine-protein kinase OS=Schistosoma bovis OX=6184 GN=DC041_0007532 PE=3 SV=1) HSP 1 Score: 588.571 bits (1516), Expect = 0.000e+0 Identity = 279/449 (62.14%), Postives = 343/449 (76.39%), Query Frame = 1
Query: 736 VRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDN-GGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V+VRALY+Y HN DL+F KGDIM V S +++ WWFA H +GYIPSNYV ++DG PTS +AW+DI EADRKLLL+GNPKGTY+IRPSS+++N ALS+RH+D E+N +VVKHY+IR LDN GG++IS RT FP+I+ LI +YT H DGLCCRL+ P PR ++PP QFR+ E+NR IT +RKLG G+FGEV+L KWN +EVAVKM R + D F+ EA+LMH HHPRIVQ+LGVCTEP P+YIITELM KGAL +FLR EEG KLTL D++ +++QIA GM+YLE VHRDLRAANILV D SVKV+DFGLA+I D+ ADP TKFPIKWTAPEA L+ +FS+KSDVWSFG+LM+EI+TYG TPY G + + EV +GYRLP P + CP +LYN+M CWDA E RPTF L D FEN++ TE QY
Sbjct: 31 VQVRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWFARHSDTGMSGYIPSNYVCLNDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLINYYTVHPDGLCCRLSIPCPRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAKWNGSVEVAVKM-RLDPTDRSRFIEEARLMHAFHHPRIVQLLGVCTEPEDQPVYIITELMRKGALYDFLRTEEGHKLTLDDLIDIMAQIASGMSYLEEMNSVHRDLRAANILVDQDYSVKVSDFGLAKIISDDSHADPNTKFPIKWTAPEAALQHIFSIKSDVWSFGILMYEIVTYGGTPYPGMTTRQTVAEVEKGYRLPCPHTPEHPCPDDLYNLMRKCWDARPENRPTFRSLYDVFENWSTHTEAQY 478 HSP 2 Score: 124.02 bits (310), Expect = 4.591e-26 Identity = 58/96 (60.42%), Postives = 73/96 (76.04%), Query Frame = 2
Query: 314 VKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD 601
V+VRALY+Y N DLSF KGDI+FV S M+D WW ARHS T GYIPSNYV ++DG PTS++ +++I EAD+KLLL+G GTY+IRPSS+
Sbjct: 31 VQVRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWFARHSDTGMSGYIPSNYVCLNDGLPTSLDAWYDIGRREADRKLLLVGNPKGTYLIRPSSE 126
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: G7YFZ5 (Tyrosine-protein kinase OS=Clonorchis sinensis OX=79923 GN=CLF_106945 PE=3 SV=1) HSP 1 Score: 587.415 bits (1513), Expect = 0.000e+0 Identity = 280/466 (60.09%), Postives = 347/466 (74.46%), Query Frame = 1
Query: 685 NYIFDTIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDN-GGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
N I P ++ V +RVRALY Y + DL F KGD M VS D++ WW A HQ TGYIPSNYV +DDG PTS +AW+DI EAD++LL +GNPKGTY+IR SS+++N ALS+RH+D ERN YVVKHY+IR LDN GY+IS+R FP+I+ LI++Y++ +GLCCRLT P PR ++PP QFR+ EVNR IT+VR+LG+GSFGEV+L KWND +EVAVKM R + D F+ EA+LMH+ HHPRIVQ+LGVCT+P P+YIITELMAKGAL++FLR +EGQ+L+L D++ M++QIA GM YLE + VHRDLRAANILV D SVKV+DFGLA+I D+ AD TKFPIKWTAPEA L+ +FS+KSDVWSFGVLM+EI+TYG TPY G + + EV +GYRLPNP CP +LYNIML CWD E RPTF L D F+N+ E QY
Sbjct: 90 NSIVQIPPPQSLPPVKQIRVRALYTYTGQHQDDLPFRKGDTMFVS-DVSAQWWLARHQKTGATGYIPSNYVLIDDGLPTSLDAWYDISRREADKRLLRVGNPKGTYLIRSSSETQNYALSVRHYDQERNIYVVKHYRIRVLDNDNGYFISNRITFPNIKDLISYYSRTAEGLCCRLTVPCPRDYRPPVQFRDFEVNRNSITMVRQLGHGSFGEVYLAKWNDSVEVAVKM-RLSHTDRTKFIEEARLMHEFHHPRIVQLLGVCTQPEDEPVYIITELMAKGALVDFLRGDEGQQLSLSDLIDMMAQIASGMTYLEERNSVHRDLRAANILVDSDNSVKVSDFGLAKIISDDAQADHSTKFPIKWTAPEAALQHIFSIKSDVWSFGVLMYEIVTYGGTPYPGMSTRQTIVEVDKGYRLPNPHTANHPCPDDLYNIMLKCWDVRPENRPTFRSLYDVFDNWASHVETQY 553 HSP 2 Score: 113.62 bits (283), Expect = 2.132e-22 Identity = 60/129 (46.51%), Postives = 87/129 (67.44%), Query Frame = 2
Query: 248 SKPPKG-VKHTTSTVPNS----------SPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD 601
S PP+G ++ + +PNS P ++VRALYTY ++ DL F KGD +FV S+++ WW+ARH +T A GYIPSNYV++DDG PTS++ +++I+ EADK+LL +G GTY+IR SS+
Sbjct: 74 SVPPQGPLQLSQPALPNSIVQIPPPQSLPPVKQIRVRALYTYTGQHQDDLPFRKGDTMFV-SDVSAQWWLARHQKTGATGYIPSNYVLIDDGLPTSLDAWYDISRREADKRLLRVGNPKGTYLIRSSSE 201
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A4S2LUM5 (Tyrosine-protein kinase OS=Opisthorchis felineus OX=147828 GN=CRM22_004736 PE=3 SV=1) HSP 1 Score: 587.03 bits (1512), Expect = 0.000e+0 Identity = 280/466 (60.09%), Postives = 347/466 (74.46%), Query Frame = 1
Query: 685 NYIFDTIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDN-GGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
N I P ++ V +RVRALY Y + DL F KGD M VS D++ WW A HQ TGYIPSNYV +DDG PTS +AW+DI EAD++LL +GNPKGTY+IR SS+++N ALS+RH+D ERN YVVKHY+IR LDN GY+IS+R FP+I+ LI++Y++ +GLCCRLT P PR ++PP QFR+ EVNR IT+VR+LG+GSFGEV+L KWND +EVAVKM R + D F+ EA+LMH+ HHPRIVQ+LGVCT+P P+YIITELMAKGAL++FLR +EGQ+L+L D++ M++QIA GM YLE + VHRDLRAANILV D SVKV+DFGLA+I D+ AD TKFPIKWTAPEA L+ +FS+KSDVWSFGVLM+EI+TYG TPY G + + EV +GYRLPNP CP +LYNIML CWD E RPTF L D F+N+ E QY
Sbjct: 90 NSIVQIPPPQSLPPVKQIRVRALYTYTGQHQDDLPFRKGDTMFVS-DVSAQWWLARHQKTGATGYIPSNYVLIDDGLPTSLDAWYDISRREADKRLLRVGNPKGTYLIRSSSETQNYALSVRHYDQERNIYVVKHYRIRVLDNDNGYFISNRITFPNIKDLISYYSRTAEGLCCRLTVPCPRDYRPPVQFRDFEVNRNSITMVRQLGHGSFGEVYLAKWNDSVEVAVKM-RLSHTDRTKFIEEARLMHEFHHPRIVQLLGVCTQPEDEPVYIITELMAKGALVDFLRGDEGQQLSLSDLIDMMAQIASGMTYLEERNSVHRDLRAANILVDSDNSVKVSDFGLAKIISDDAQADHSTKFPIKWTAPEAALQHIFSIKSDVWSFGVLMYEIVTYGGTPYPGMSTRQTIVEVDKGYRLPNPHTANHPCPDDLYNIMLKCWDVRPENRPTFRSLYDVFDNWASHVETQY 553 HSP 2 Score: 112.849 bits (281), Expect = 3.486e-22 Identity = 60/129 (46.51%), Postives = 86/129 (66.67%), Query Frame = 2
Query: 248 SKPPKG-VKHTTSTVPNS----------SPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD 601
S PP+G ++ +PNS P ++VRALYTY ++ DL F KGD +FV S+++ WW+ARH +T A GYIPSNYV++DDG PTS++ +++I+ EADK+LL +G GTY+IR SS+
Sbjct: 74 SVPPQGPLQLNQPALPNSIVQIPPPQSLPPVKQIRVRALYTYTGQHQDDLPFRKGDTMFV-SDVSAQWWLARHQKTGATGYIPSNYVLIDDGLPTSLDAWYDISRREADKRLLRVGNPKGTYLIRSSSE 201
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: fyna (tyrosine-protein kinase fyna [Source:NCBI gene;Acc:103043249]) HSP 1 Score: 420.624 bits (1080), Expect = 2.029e-138 Identity = 214/456 (46.93%), Postives = 294/456 (64.47%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSI+ +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY+ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VAVK ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV D L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +ML CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 89 ALYDYEARTEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSNGNPRGTFLIRESETTKGAYSLSIQDWDDIKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSARAAGLCCRLIVPCHKGMPRLADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEYMGKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPISLHELMLQCWKRDPEERPTFEYLQAFLEDYFTATEPQYQPGDN 536 HSP 2 Score: 65.4698 bits (158), Expect = 1.492e-10 Identity = 35/91 (38.46%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S
Sbjct: 89 ALYDYEARTEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSNGNPRGTFLIRESE 179
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: yrk (proto-oncogene tyrosine-protein kinase Yrk [Source:NCBI gene;Acc:103036565]) HSP 1 Score: 417.927 bits (1073), Expect = 2.344e-137 Identity = 211/451 (46.78%), Postives = 293/451 (64.97%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLT----EPFPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY+Y+ DL F KG+ + ++ WW A ++GYIPSNYV+ D + + +A+R+LL NP+GT++IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R+ F ++ L+ HY+ GLCCRL P+ + +++ E+ R+ + L++KLGNG FGEVW+G WN +VAVK ++P M + FL EAQ+M +L H ++VQ+ V +E PIYIITE M++G+LL+FL++ EG+ L L ++ M +QIA GMAY+E ++HRDLRAANILV D+L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E+IT GR PY G N +VLE+V RGYR+P PQG P L+ +ML CW +++R TF +L+ E+Y ATE QY
Sbjct: 89 ALYDYDARTEDDLTFQKGEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLGQNNPRGTFLIRESETTKGAYSLSIRDWDDAKGDHV-KHYKIRKLDNGGYYITTRSQFETVQQLVVHYSDRAAGLCCRLIGSCRRGMPKLADLSVKTKDVWEIPRESLQLIKKLGNGQFGEVWMGMWNGTTKVAVKTLKPGTMSPEAFLDEAQIMKRLRHDKLVQLYAVVSE---EPIYIITEFMSQGSLLDFLKDGEGRSLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCPQG----SPASLHELMLQCWRKDADERHTFEYLQGFLEDYFTATEPQY 531 HSP 2 Score: 65.855 bits (159), Expect = 1.074e-10 Identity = 35/91 (38.46%), Postives = 47/91 (51.65%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY YD R DL+F KG+ + +N WW AR T GYIPSNYV D F ++ +A+++LL GT++IR S
Sbjct: 89 ALYDYDARTEDDLTFQKGEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLGQNNPRGTFLIRESE 179
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: lyn (tyrosine-protein kinase Lyn-like [Source:NCBI gene;Acc:103026730]) HSP 1 Score: 413.69 bits (1062), Expect = 4.613e-136 Identity = 217/452 (48.01%), Postives = 292/452 (64.60%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPF--PRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITE-DEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V ALY Y + DL F KG+ + V + E WW A + G+IPSNYV+ D T E WF +I +A+R+LL N G Y+IR S S+ +LSIR P+ + VVKHYKIR+LDNGGYYIS + FPDI +I HY + DGLC +L P P+ KP + E++++ I +V+KLG G FGEVW+ +N+ +VAVK ++P M + FL EA LM L H R+V++ V T+ PIYIITE MA G+LL+FL+ + G KL L ++ +QIAEGMAY+E K ++HRDLRAAN+LVS+ L K+ADFGLAR+ E D+Y A G KFPIKWTAPEA F++KSD+WSFG+L++EIITYG+ PY G N +V+ V RGYR+P P+ CP ELY+IM +CW + RPTF +++ +++ ATE QY
Sbjct: 71 VIALYPYEAIHTDDLGFKKGEKLRVLEEHGE-WWKAKSLSTRKEGFIPSNYVAQADTMET--EEWFFKEITRKDAERQLLAPANKPGAYLIRESETSKGSYSLSIRDAGPQGSD-VVKHYKIRSLDNGGYYISPKITFPDIIKMIHHYHKQADGLCRKLERPCEKPKAQKP-WDKDAWEISKESIKMVKKLGAGQFGEVWMAYYNNTTKVAVKTLKPGTMSVEAFLEEANLMKTLQHERLVRLYAVVTKI--EPIYIITEFMANGSLLDFLKSDAGSKLQLPKLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSESLLCKIADFGLARVIEDDQYTAREGAKFPIKWTAPEAINYGSFTIKSDMWSFGILLYEIITYGKIPYPGMSNGEVMTSVQRGYRMPRPES----CPTELYDIMNTCWKNKPDDRPTFDYIQSVLDDFYTATEGQY 511 HSP 2 Score: 64.3142 bits (155), Expect = 3.019e-10 Identity = 38/96 (39.58%), Postives = 49/96 (51.04%), Query Frame = 2
Query: 311 GVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
G V ALY Y+ + DL F KG+ L V + WW A+ T G+IPSNYV D T F EI +A+++LL PG Y+IR S
Sbjct: 68 GKIVIALYPYEAIHTDDLGFKKGEKLRVLEEHGE-WWKAKSLSTRKEGFIPSNYVAQADTMETEEWFFKEITRKDAERQLLAPANKPGAYLIRESE 162
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: clul1 (tyrosine-protein kinase yes [Source:NCBI gene;Acc:103029125]) HSP 1 Score: 412.535 bits (1059), Expect = 3.033e-135 Identity = 212/453 (46.80%), Postives = 288/453 (63.58%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTE--PFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y + DL+F KGD + ++ WW A + GYIPSNYV+ D + + +A+R LL+ GN +GT+++R S ++ +LSIR +D + V KHYKIR LDNGGYYI+ R F ++ L+ HYT+H DGLC RLT P + E+ R+ + L KLG G FGEVW+G WN +VA+K ++P M + FL EAQ+M KL H ++V + V +E PIYI+TE M KG+LL+FL+E EG+ L L ++ M +QIA+GMA++E ++HRDLRAANILV D+L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQG CP L+ +M CW ++RPTF +++ E+Y ATE QY D+
Sbjct: 102 ALYDYEARTSDDLSFKKGDRFQIINNTEGDWWEARSINTGKKGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLVPGNQRGTFLVRESETTKGAYSLSIRDWDDMKGDNV-KHYKIRKLDNGGYYITTRAQFETLQKLVKHYTEHADGLCYRLTTVCPTVKPQTQGLAKDAWEIPRESLRLELKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLQEAQIMKKLRHDKLVPLYAVVSE---EPIYIVTEYMGKGSLLDFLKEGEGKYLKLPQLVDMAAQIADGMAFIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQG----CPESLHEMMRLCWKKEPDERPTFEYIQSFLEDYFTATEPQYQPGDN 546 HSP 2 Score: 68.1662 bits (165), Expect = 2.019e-11 Identity = 36/91 (39.56%), Postives = 48/91 (52.75%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KGD + +N WW AR T GYIPSNYV D F ++ +A++ LL+ G GT+++R S
Sbjct: 102 ALYDYEARTSDDLSFKKGDRFQIINNTEGDWWEARSINTGKKGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLVPGNQRGTFLVRESE 192
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: yrk (proto-oncogene tyrosine-protein kinase Yrk [Source:NCBI gene;Acc:103036565]) HSP 1 Score: 406.757 bits (1044), Expect = 2.695e-133 Identity = 210/448 (46.88%), Postives = 289/448 (64.51%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQF-REI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY+Y+ DL F KG+ + ++ WW A ++GYIPSNYV+ D + + +A+R+LL NP+GT++IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R+ F ++ L+ HY+ DGLC LT+ P R+ E++R + L RKLG G FG+V++G WN +VAVK ++P M + FL EAQ+M +L H ++VQ+ V +E PIYIITE M++G+LL+FL++ EG+ L L ++ M +QIA GMAY+E ++HRDLRAANILV D+L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E+IT GR PY G N +VLE+V RGYR+P PQG P L+ +ML CW +++R TF +L+ E+Y ATE QY
Sbjct: 74 ALYDYDARTEDDLTFQKGEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLGQNNPRGTFLIRESETTKGAYSLSIRDWDDAKGDHV-KHYKIRKLDNGGYYITTRSQFETVQQLVVHYSGTHDGLCYFLTKACPNSTPQTLGLGRDAWEISRDTLQLKRKLGQGCFGDVYMGMWNGTTKVAVKTLKPGTMSPEAFLDEAQIMKRLRHDKLVQLYAVVSE---EPIYIITEFMSQGSLLDFLKDGEGRSLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCPQG----SPASLHELMLQCWRKDADERHTFEYLQGFLEDYFTATEPQY 513 HSP 2 Score: 65.855 bits (159), Expect = 1.084e-10 Identity = 35/91 (38.46%), Postives = 47/91 (51.65%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY YD R DL+F KG+ + +N WW AR T GYIPSNYV D F ++ +A+++LL GT++IR S
Sbjct: 74 ALYDYDARTEDDLTFQKGEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLGQNNPRGTFLIRESE 164
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: hck (HCK proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-090313-72]) HSP 1 Score: 417.157 bits (1071), Expect = 4.796e-139 Identity = 218/453 (48.12%), Postives = 289/453 (63.80%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREI---EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V ALY++ N D+ F KGD M + + E WW A GYIPSNYV+ + T E WF + E +R LL GN G Y++R S ++ +LS+R +D N VV+HYKIRTLDNGGY+IS R FPD+ LI HYT H+DGLC +L P K P Q E E+ R + L ++LG G FGEVW+G +N+ +VA+K M+P M + FL EA LM L HPR+V++ V T+ PIYI+TE M G+LL++L+ EG L + M+ M +QIAEGMA++E K ++HRDLRAANILV++ L+ K+ADFGLARI ED EY A G KFPIKWTAPEA FS+KSDVWSFG+L+ EIIT+GR PY G N V+ ++ RGYR+P P+ + P +LY +M+ CW E+RPTF +L+ E++ +TE QY
Sbjct: 3 VVALYDFEQLNPDDMGFKKGDKMRIIQERGE-WWMAELMDGSHKGYIPSNYVAKANSLET--EEWFFSGVSRKEGERLLLAPGNSIGAYLLRDSESNKGSYSLSVRDYDIT-NGDVVRHYKIRTLDNGGYFISARLTFPDLFALIQHYTAHSDGLCQKLLRPCV--SKKPQQLWEKDAWEIPRDSLKLSKRLGAGQFGEVWMGIYNNRTKVAIKTMKPGSMSPEAFLDEANLMKTLQHPRLVRLYAVVTQ---EPIYIVTEFMENGSLLDYLKSTEGSTLPMPKMIDMAAQIAEGMAFIERKNYIHRDLRAANILVNEQLASKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFSIKSDVWSFGILLTEIITFGRIPYPGMSNSDVIRQLERGYRMPCPE----QAPKQLYGVMMDCWKERPEERPTFEYLQGVLEDFFTSTEGQY 442 HSP 2 Score: 57.7658 bits (138), Expect = 5.674e-9 Identity = 33/93 (35.48%), Postives = 47/93 (50.54%), Query Frame = 2
Query: 320 VRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
V ALY ++ NP D+ F KGD + + + WW+A GYIPSNYV + T F ++ E ++ LL G S G Y++R S
Sbjct: 3 VVALYDFEQLNPDDMGFKKGDKMRIIQERGE-WWMAELMDGSHKGYIPSNYVAKANSLETEEWFFSGVSRKEGERLLLAPGNSIGAYLLRDSE 94
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: clul1 (clusterin-like 1 (retinal) [Source:ZFIN;Acc:ZDB-GENE-031118-57]) HSP 1 Score: 410.994 bits (1055), Expect = 2.606e-136 Identity = 219/471 (46.50%), Postives = 294/471 (62.42%), Query Frame = 1
Query: 706 PQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNE--------PWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQ--FREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
PQ T + ALY+Y+ DL+F KG+ + ++ E WW A GYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSIR +D E VKHYKIR LDNGGYYI+ R F ++ L+ HY++H DGLC +LT P + KP Q R+ E+ R + L KLG G FGEVW G WN +VA+K ++P M + FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL+E +G+ L L ++ M +QIA GMAY+E ++HRDLRAANILV D+L K+ADFGLAR+ ED EY A G KFPIKWTAPEA + F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P P CP L+ +M+ CW E+RPTF +L+ E+Y ATE QY
Sbjct: 6 PQRTHLTGGVTLFVALYDYDARTQDDLSFRKGEKFQIINNTIEVAVVYREGDWWEARSLSTGNKGYIPSNYVAPADSVQAEEWYFGKVSRKDAERQLLCPGNPRGTFLIRESETTKGAYSLSIRDWD-EVKGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVQHYSEHADGLCYKLTLVCPNE-KPQTQGLARDAWEMPRDSLKLELKLGQGCFGEVWAGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEFMSKGSLLDFLKEGDGRYLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAMFGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPPS----CPESLHELMMQCWKKDPEERPTFEYLQAFLEDYFTATEPQY 467 HSP 2 Score: 62.7734 bits (151), Expect = 1.826e-10 Identity = 37/99 (37.37%), Postives = 49/99 (49.49%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNM--------NDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY YD R DLSF KG+ + +N WW AR T GYIPSNYV D F +++ +A+++LL G GT++IR S
Sbjct: 20 ALYDYDARTQDDLSFRKGEKFQIINNTIEVAVVYREGDWWEARSLSTGNKGYIPSNYVAPADSVQAEEWYFGKVSRKDAERQLLCPGNPRGTFLIRESE 118
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: hck (HCK proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-090313-72]) HSP 1 Score: 396.356 bits (1017), Expect = 4.041e-130 Identity = 212/456 (46.49%), Postives = 291/456 (63.82%), Query Frame = 1
Query: 727 VASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP-FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
V + V ALY+Y+ +A DL F +GD +V+ + N+ WW A + GYIPSN+V+ + E WF + +A+R+LLL GN G+Y+IR S ++ +LS+R E VKHYKIRTLD GGY+I+ R F ++ L+ +Y DGLC +L +P Q + P++ E+ R+ I L +KLG G FG+VW+G +N +VAVKMM+P M FL EA LM L H ++V++ V T+ PI+I+TE M KG+LL+FL+ EG +L M+ M +Q+AEGMA++E K ++HRDLRAANILV+ +L K+ADFGLARI ED EY A G KFPIKWTAPEA FS+KSDVWSFG+L+ E++T+GR PY G N +V+ + RGYR+P P CP ELY+IM CW E+RPTF +L+ E++ ATE QY
Sbjct: 63 VDGLLVVALYDYDPIHADDLCFRRGDQLVIVEEGND-WWKARSVATKKEGYIPSNFVAKVNSI--EKEEWFFKGLSRKDAERQLLLCGNKIGSYLIRDSETNKGSYSLSVRDHIVEVG-DTVKHYKIRTLDKGGYFITSRITFHTLQELVVYYHLKADGLCQKLGKPCIAIQPQKPWEKDAWEIPRESIKLEKKLGAGQFGDVWMGVYNKKTKVAVKMMKPGSMAPQAFLEEANLMKTLQHDKLVRLHAVVTD---EPIFIVTEYMEKGSLLDFLKTSEGSRLKQPKMIDMCAQVAEGMAFIEDKNYIHRDLRAANILVNVNLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFSIKSDVWSFGILLTEMVTFGRIPYPGMTNPEVIRSLERGYRMPKPDN----CPCELYSIMQECWRQKPEERPTFEYLQSLLEDFYTATELQY 507 HSP 2 Score: 67.781 bits (164), Expect = 4.983e-12 Identity = 41/97 (42.27%), Postives = 55/97 (56.70%), Query Frame = 2
Query: 311 GVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
G+ V ALY YD + DL F +GD L + ND WW AR T GYIPSN+ V S E FF+ ++ +A+++LLL G G+Y+IR S
Sbjct: 65 GLLVVALYDYDPIHADDLCFRRGDQLVIVEEGND-WWKARSVATKKEGYIPSNF-VAKVNSIEKEEWFFKGLSRKDAERQLLLCGNKIGSYLIRDSE 159
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7]) HSP 1 Score: 360.533 bits (924), Expect = 6.082e-117 Identity = 205/466 (43.99%), Postives = 280/466 (60.09%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFA------THQGNFQT-GYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLD-NGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPP---FQFREI---EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARIT----EDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLK---DTFE----NYTIA 2064
ALY+Y+ DL+F +G+++ V+ N WW+A T + T GYIP+NYV+ + E WF DI ++A++ LL N G ++IR S+SR S+ R+ VKHY+IR LD NGG++IS R F ++ L+ +Y ++DGLC L +P P + + E+ R I L ++LG G FGEVW G WN+ VAVK ++P M + F+GEAQ+M +L H ++Q+ VC++ PIYIITELM G+LL++LR G++L +++ M QIA GMAYLES+ ++HRDL A NILV + KVADFGLARI EDEY G K PIKWTAPEA FSVKSDVWSFG+L++E+ITYGR PY N +VL+++ RGYR+P P CP Y+IML CW+ E+RPTF L+ D F+ NYT A
Sbjct: 3 ALYDYDGRTNEDLSFKEGELLEVTDKTNSDWWYAQKKTASTSNERYNTRGYIPANYVA--EYQSLDAEPWFFGDIKRADAEKYLLADVNTTGAFLIR-QSESRKTDYSL----SVRDGSTVKHYRIRQLDENGGFFISRRVTFQNLIELVQYYKSNSDGLCMALQKPCVVIEAPTTIGLSYNTVDKWEIPRASIQLQKRLGAGMFGEVWQGLWNNSTLVAVKTLKPGAMKKEEFIGEAQIMKQLRHANLIQLYAVCSQE--EPIYIITELMRHGSLLDYLRGPLGKQLKAPELVDMARQIAAGMAYLESQNYIHRDLAARNILVGEGKVCKVADFGLARIIKVRYEDEYEGKAGAKVPIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYGRMPYPEMGNMEVLKQLDRGYRMPQPDN----CPPLFYSIMLECWNKKEEERPTFETLQWRLDYFDSDPNNYTDA 455 HSP 2 Score: 59.3066 bits (142), Expect = 1.825e-9 Identity = 36/98 (36.73%), Postives = 49/98 (50.00%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVAR-------HSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY YD R DLSF +G++L VT N WW A+ + R + GYIP+NYV F +I +A+K LL + G ++IR S
Sbjct: 3 ALYDYDGRTNEDLSFKEGELLEVTDKTNSDWWYAQKKTASTSNERYNTRGYIPANYVAEYQSLDAEPWFFGDIKRADAEKYLLADVNTTGAFLIRQSE 100
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006670.1 (pep scaffold:Pmarinus_7.0:GL482639:18:11990:1 gene:ENSPMAG00000006016.1 transcript:ENSPMAT00000006670.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 342.813 bits (878), Expect = 2.950e-111 Identity = 173/374 (46.26%), Postives = 239/374 (63.90%), Query Frame = 1
Query: 967 KLLLMGNPKGTYIIRPSSDS-RNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQ------FREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARI----TEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENY 2055
+L+ GN G++++R S S +LS+R D VKHYKIR L+ G ++I+ R F +R L+ Y++ +GLC L +P ++ P + + E+ R + LV++LG G FGEVW G WN VA+K ++ MD D FL EAQLM +L HP+++Q+ VCT+ PIYIITELM+ G+L N+L+ EG+ L L +++ M +Q+A GMAYLE++ ++HRDL A NILV++ + KVADFGLAR+ EDEY A G+KFPIKWTAPEA FS+KSDVWSFGVL+ EIITYG+ PY G N +VL V RGYR+P P G CP Y++ML CW+ + RPTF L+ E++
Sbjct: 9 QLMKSGNVHGSFLVRQSETSGHGYSLSVRDGD------TVKHYKIRVLEKGSFFITRRNQFATLRDLVQSYSRDANGLCVTLNQPCLKKEMPQTEGLSSDMADKWEIPRSSVQLVKRLGAGQFGEVWQGLWNKTTPVAIKTLKQGTMDRDDFLREAQLMKRLRHPKLIQLYAVCTQE--EPIYIITELMSNGSLANYLQTPEGRSLDLVELVDMAAQVAAGMAYLEAQNYIHRDLAARNILVAEHNACKVADFGLARVIKMSNEDEYEARVGSKFPIKWTAPEAANYNRFSIKSDVWSFGVLLHEIITYGKLPYPGQTNAEVLAAVDRGYRMPCPPG----CPQAFYDLMLECWNVDDQARPTFETLQWQLEDF 370
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 96.2857 bits (238), Expect = 6.576e-21 Identity = 72/249 (28.92%), Postives = 117/249 (46.99%), Query Frame = 1
Query: 1285 LVRKLGNGSFGEVW--LGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFL-REEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPT 2022
L + +G GS+G V+ + K D + +++ N + + + E L+ L+H IV+ G + +YI+ E A G+L + R G L+ + ++Q G+ YL + +HRD++AANIL+S D +VK+ADFG++ I L GT + W APE R S SD+WS G + E++T PY + + V P + L + + C+ KRPT
Sbjct: 27 LKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRK--SYELYILLEYCANGSLRRLISRSSTG--LSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGT---LNWMAPEILGNRGASTLSDIWSLGATVVEMLT-KNPPYHNLTDANIYYAVENDTYYPPSSFSE-----PLKDFLSKCFVKNMYKRPT 262
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631]) HSP 1 Score: 90.5077 bits (223), Expect = 4.971e-19 Identity = 75/273 (27.47%), Postives = 134/273 (49.08%), Query Frame = 1
Query: 1297 LGNGSFGEVWL------GKWNDIIEVAV-KMMRPN---CMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLL--MLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYL-ADPGTKFPIKWTAPE-AGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGEL-YNIMLSCWDATSEKRPT--------FSFLKDTF 2046
+G GSFG V+L G+ + +V V K N + E + L H IVQ LG E + + E +A G++ + +R G+ + L+ + +Q+ +G+AYL SK +HRD++A N+L+ D K++DFG++R ++D Y +D + + W APE K+ +S K D+WS G ++ E+ G+ P++ + + ++ + P + ++ N + +C++ EKRPT FS + +TF
Sbjct: 1181 IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGF--ENKNNIYSLFLEYVAGGSVGSLIRMY-GR---FDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFA-GKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETF 1446
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: CMK1 (Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication [Source:SGD;Acc:S000001910]) HSP 1 Score: 84.3445 bits (207), Expect = 1.468e-17 Identity = 71/233 (30.47%), Postives = 115/233 (49.36%), Query Frame = 1
Query: 1264 VNRKCITLVRKLGNGSFGEVWLGKWNDIIE-VAVKMM-----RPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILV---SDDLSVKVADFGLAR--ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKV---LEEVSRG 1920
VN+K + LG G+FG V K + E VAVK++ + N + + E ++ +LHHP IV + YIIT+L G L F R + K T +D + +L +I + Y+ S+ VHRDL+ N+L SD+ + VADFG+A+ +++E L P + + APE + D+WS GV+ + ++ Y+ F+ +V L+E + G
Sbjct: 32 VNKKKYVFGKTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIVAFKDWFE--SKDKFYIITQLAKGGEL--FDRILKKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAG--SLGYVAPEVLTQDGHGKPCDIWSIGVITYTLL----CGYSAFRAERVQDFLDECTTG 254
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 82.8037 bits (203), Expect = 2.633e-17 Identity = 60/233 (25.75%), Postives = 112/233 (48.07%), Query Frame = 1
Query: 1234 KPPFQFREI--EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEV-AVKMMRPNCM----DSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEV 1911
KP Q+R+ + + ++R LG GSFG V L + N A+K ++ + + + E +++ + HP I+++ G + ++++ + + G L + LR+ Q+ +++ + YL SK ++RDL+ NIL+ + +K+ DFG A+ D GT + APE + ++ D WSFGVL++E++ G TP+ K E +
Sbjct: 71 KPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQD--SQQVFMVMDYIEGGELFSLLRK--SQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTP---DYIAPEVVSTKPYNKSVDWWSFGVLIYEMLA-GYTPFYNSNTMKTYENI 295
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529]) HSP 1 Score: 84.3445 bits (207), Expect = 3.740e-17 Identity = 63/216 (29.17%), Postives = 102/216 (47.22%), Query Frame = 1
Query: 1342 DIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFL------REEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDE----------YLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQ 1941
D++E K+ + D T + EA L L+HP I ++ +CT + Y++ E ++ G LL+++ RE + +K IA + YL + VHRDL+ NI++SD +K+ DFGL+ I + Y A P +T PE DVWSFGV++F ++ G+ P+ +N VL E + ++ PQ
Sbjct: 173 DVLERQKKLEKEISRDKRT-IREASLGQILYHPHICRLFEMCT--LSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFA--------RGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKANPYTGPEV----------DVWSFGVVLF-VLVCGKVPFDD-ENSSVLHEKIKQGKVEYPQ 365
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18]) HSP 1 Score: 241.506 bits (615), Expect = 1.115e-73 Identity = 124/260 (47.69%), Postives = 168/260 (64.62%), Query Frame = 1
Query: 1255 EIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIE-VAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCT-EPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLAR-ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTF 2025
E E+ R I + KLG G +GEV+ G W + VAVK +R M+ + FL EA +M + H +VQ+LGVCT EP P YIITE M G LL++LR +G+ L ++ M +Q+ M+YLES F+HRDL A N LV D+ VKVADFGL+R ++ED Y A G KFPIKWTAPEA FS+KSDVW+FG+L++E+ TYG +PY G +V +++ GYR+P P+G CP E+Y++M +CW RP+F
Sbjct: 6 EWEIERTEIAMKHKLGGGQYGEVYEGTWKKYNKTVAVKTLREETMEVEEFLKEASVMKGIKHQNLVQLLGVCTREP---PFYIITEFMMNGNLLDYLRSPKGKDLDAVTLMYMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLVSEDIYTAHQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYRMPCPEG----CPPEVYSLMQTCWCWDPNSRPSF 258
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO49804 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFY7]) HSP 1 Score: 207.994 bits (528), Expect = 3.165e-62 Identity = 106/221 (47.96%), Postives = 140/221 (63.35%), Query Frame = 1
Query: 1336 WNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLAR-ITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCW 1995
W I VAVKMM+ M + F+ EA++M + H +VQ+ G+C+E PIYII ELM G LL++LR+ + KL +M M+ Q+A M YLES F+HRDL A N L+ ++ +VKVADFGLAR + +DEY A GTKFPIKW APE L FS KSDVW+FG+L +E+ T G+ PY N V++ V GYRL P ++CP Y+ M CW
Sbjct: 2 WRGTIPVAVKMMKDGAMSEEDFIEEAKVMKQFQHGNLVQLYGICSE---KPIYIIQELMKGGCLLHYLRKSQF-KLQSAEMTEMVRQVAAAMKYLESHNFIHRDLAARNCLIGENRTVKVADFGLARYVIDDEYTASEGTKFPIKWAAPEVILYSKFSSKSDVWAFGILAWEVYTGGKQPYPATNNTDVVQMVINGYRLEKP----LRCPDAAYSTMRKCW 214
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO33736 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD7]) HSP 1 Score: 200.675 bits (509), Expect = 2.534e-57 Identity = 111/276 (40.22%), Postives = 165/276 (59.78%), Query Frame = 1
Query: 1261 EVNRKCITLVRKLGNGSFGEVWLGKWND----IIEVAVKMMRPNC--MDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-------EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFE 2049
E+N+ + L +G G F +V+ G + +VAVK+++P + + F EA +M + HP ++ + GV T P+ IITE + G+L NFL+ +G+ TLQ ++ + +A GMAYL F+HRDL A NILVSD+L+ KV+DFGL+R +D EY G K P++WTAPEA R FS SDVWS+G+L++EI+++G PY + N +V++ V GYRLP P +KCP ++N+ML CWD RP F+ + F+
Sbjct: 21 EINKDDLKLEIIIGGGEFADVYRGVLTNEDKTQEKVAVKILKPGSSHKNREDFCVEASIMGQFDHPNVIALKGVITRT--RPMMIITEFLENGSLDNFLKSNDGRLTTLQ-LVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQ-GGKIPVRWTAPEAIRYRKFSSASDVWSYGILLWEIMSFGERPYWTWDNFQVMDRVEGGYRLPAP----MKCPKVIHNLMLDCWDKEKTSRPKFADIVRRFD 288
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO40994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K8]) HSP 1 Score: 200.675 bits (509), Expect = 4.010e-57 Identity = 107/277 (38.63%), Postives = 163/277 (58.84%), Query Frame = 1
Query: 1261 EVNRKCITLVRKLGNGSFGEVWLGKWN----DIIEVAVKMMRPNCMDSD--TFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATER 2073
E++++ + L + +G G FG+V+ G + I VA+K ++ + FL EA +M + P ++ + GV ++ P+ I+TE M+ G+L NFL++ + KL+L ++ M IA GM YL FVHRDL A NILV++ L KVADFGL+R ED G K P++WTAPEA R FS SDVWS+G+L++E ++ PY + N +V++ V GYRLP P + CP ++ IML CWDA KRP+F+ + ++ + E+
Sbjct: 52 ELDKRWLKLEKVIGGGEFGDVYKGTLKRPGENTIPVAIKTLKQGSTSKNRGDFLSEASVMGQFCDPNVIFLEGVVSKT--HPLMIVTEFMSNGSLDNFLKKMDS-KLSLIQLMGMARGIASGMKYLSEMNFVHRDLAARNILVTETLVCKVADFGLSRELEDSAYETSGGKIPVRWTAPEAIKYRKFSTSSDVWSYGILLWETFSFAERPYWDWSNFEVMDRVETGYRLPPP----MSCPKVIHQIMLECWDADRTKRPSFALIVKQLDSLIRSPEK 321
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO47652 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7RLS3]) HSP 1 Score: 194.512 bits (493), Expect = 3.821e-56 Identity = 116/275 (42.18%), Postives = 159/275 (57.82%), Query Frame = 1
Query: 1255 EIEVNRKCITLVRKLGNGSFGEVWLGKWNDII------EVAVKMMRPNC--MDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLR--------EEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLAR-ITEDEYLADPGTK-FPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTF 2025
E EV R+ I L+R+LGNGSFG V+ G+ DI+ +VAVK + N D FL EA +M +V++LGV ++ G P ++ ELM G L NFLR E + TLQ ML M +IA+GMAYL ++ FVHRDL A N +V+ +L+VK+ DFG+ R I E +Y G P++W APE+ VF+ SDVWSFGV+M+E+ T PY G N +VL+ V G +P P CP L+++M CW + + RPTF
Sbjct: 10 EWEVPREKIKLIRELGNGSFGMVYEGEATDIVPNKPKCKVAVKTVSENASIRDRIEFLQEASIMKAFQCNHVVRLLGVVSD--GQPTLVVMELMDNGDLKNFLRSHRPEVTMESDEPPPTLQQMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNANLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQPYPGKSNEEVLKYVVDGGVMPKPD----DCPDRLFDLMTLCWQFSPKARPTF 278
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: fyna (tyrosine-protein kinase fyna [Source:NCBI gene;Acc:101157019]) HSP 1 Score: 419.468 bits (1077), Expect = 4.708e-138 Identity = 216/476 (45.38%), Postives = 301/476 (63.24%), Query Frame = 1
Query: 715 TTMQVASVRVR---------ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP----FPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
T+ Q ++R R ALY+Y DL+F KG+ + + WW A TGYIPSNYV+ D + + +A+R+LL GN +GT++IR S ++ +LSI+ +D + +V KHYKIR LDNGGYYI+ R F ++ L+ HY+ GLCCRL P PR + +++ E+ R+ + L+++LGNG FGEVW+G WN +VAVK ++P M ++FL EAQ+M KL H ++VQ+ V +E PIYI+TE M+KG+LL+FL++ EG+ L L +++ M +Q+A GMAY+E ++HRDLR+ANILV D L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQ CP L+ +M+ CW E+RPTF +L+ E+Y ATE QY D+
Sbjct: 69 TSSQSGTLRSRGGTGVTLFVALYDYEARTEDDLSFRKGERFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSSGNARGTFLIRESETTKGAYSLSIQDWDDIKGDHV-KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSARAAGLCCRLIAPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDGLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ----DCPTSLHELMVQCWKKDPEERPTFEYLQAFLEDYFTATEPQYQPGDN 536 HSP 2 Score: 67.0106 bits (162), Expect = 4.644e-11 Identity = 35/91 (38.46%), Postives = 49/91 (53.85%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KG+ + ++ WW AR T GYIPSNYV D F ++ +A+++LL G + GT++IR S
Sbjct: 89 ALYDYEARTEDDLSFRKGERFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSSGNARGTFLIRESE 179
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: yrk (proto-oncogene tyrosine-protein kinase Yrk [Source:NCBI gene;Acc:101155365]) HSP 1 Score: 418.698 bits (1075), Expect = 8.707e-138 Identity = 213/451 (47.23%), Postives = 293/451 (64.97%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRL----TEPFPRQHKPPFQFREI-EVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY+Y+ DL F KG+ + ++ WW A ++GYIPSNYV+ D + + +A+R+LL GNP+GT++IR S ++ +LSIR +D + +V KHYKIR LDNGGYYI+ R+ F ++ L+ HYT+ GLCCRL P+ + +++ E+ R+ + L++KLGNG FGEVW+G WN +VAVK ++P M + FL EAQ+M +L H ++VQ+ V +E PIYIITE M++G+LL+FL++ EGQ L L ++ M +QIA GMAY+E ++HRDLRAANILV D+L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E+IT GR PY G N +VLE+V RGYR+P G CP L+ +ML CW ++R TF +L+ E+Y ATE QY
Sbjct: 81 ALYDYDARTEDDLTFQKGEKFQIINNTEGDWWEARSLDTGKSGYIPSNYVAPIDSIQAEEWYFGKMGRKDAERQLLGQGNPRGTFLIRESETTKGAYSLSIRDWDDTKGDHV-KHYKIRKLDNGGYYITTRSQFDTVQQLVEHYTERAAGLCCRLIGSCKRGMPKLADLSVKTKDMWEIPRESLQLIKKLGNGQFGEVWMGMWNGTTKVAVKTLKPGTMSPEAFLEEAQIMKRLRHDKLVQLYAVVSE---EPIYIITEFMSEGSLLDFLKDGEGQTLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCAPG----CPASLHELMLQCWRREPDERHTFEYLQSFLEDYFTATEPQY 523 HSP 2 Score: 68.1662 bits (165), Expect = 2.024e-11 Identity = 44/135 (32.59%), Postives = 65/135 (48.15%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSDCAIKTSWEIV*KDPPQTRAPQVHSNQL--------IITSLTQF 706
ALY YD R DL+F KG+ + +N WW AR T GYIPSNYV D F ++ +A+++LL G GT++IR S K ++ + +D T+ V ++ IT+ +QF
Sbjct: 81 ALYDYDARTEDDLTFQKGEKFQIINNTEGDWWEARSLDTGKSGYIPSNYVAPIDSIQAEEWYFGKMGRKDAERQLLGQGNPRGTFLIRESE--TTKGAYSLSIRDWDDTKGDHVKHYKIRKLDNGGYYITTRSQF 213
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: clul1 (tyrosine-protein kinase Yes [Source:NCBI gene;Acc:101162321]) HSP 1 Score: 414.075 bits (1063), Expect = 8.976e-136 Identity = 212/453 (46.80%), Postives = 292/453 (64.46%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTE--PFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
ALY+Y A DL+F KGD + ++ WW A +TG+IPSNYV+ D + + +A+R LLL+G +GT+++R S ++ ++SIR +D E VKHYKIR LD+GGYYI+ R F ++ L+ HYT+H DGLC RLT P + E+ R+ + L KLG G FGEVW+G WN +VA+K ++P M + FL EAQ+M KL H ++V + V +E PIYI+TE M KG+LL+FL+E +G+ L L ++ M SQIA+GMA++E ++HRDLRAANILV+D+L K+ADFGLAR+ ED EY A G KFPIKWTAPEA L F++KSDVWSFG+L+ E++T GR PY G N +VLE+V RGYR+P PQG CP L+++M+ CW ++RPTF +++ E+Y ATE QY D+
Sbjct: 102 ALYDYEARTADDLSFKKGDRFQIINNTEGDWWEARSINTGETGFIPSNYVAPADSIQAEEWYFGKLGRKDAERLLLLVGTQRGTFLVRESETTKGAYSVSIRDWD-EVKGDNVKHYKIRKLDSGGYYITTRAQFDTLQKLVRHYTEHADGLCYRLTTVCPVVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLQEAQIMKKLRHDKLVPLYAVVSE---EPIYIVTEFMGKGSLLDFLKEGDGKCLKLPQLVDMASQIADGMAFIERMNYIHRDLRAANILVADNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQG----CPESLHDMMMQCWKKDPDERPTFEYIQFFLEDYFTATEPQYQPGDN 546 HSP 2 Score: 70.8626 bits (172), Expect = 2.504e-12 Identity = 36/91 (39.56%), Postives = 49/91 (53.85%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ R DLSF KGD + +N WW AR T G+IPSNYV D F ++ +A++ LLL+G GT+++R S
Sbjct: 102 ALYDYEARTADDLSFKKGDRFQIINNTEGDWWEARSINTGETGFIPSNYVAPADSIQAEEWYFGKLGRKDAERLLLLVGTQRGTFLVRESE 192
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: hck (HCK proto-oncogene, Src family tyrosine kinase [Source:NCBI gene;Acc:101163900]) HSP 1 Score: 410.994 bits (1055), Expect = 2.396e-135 Identity = 218/465 (46.88%), Postives = 297/465 (63.87%), Query Frame = 1
Query: 703 IPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP--FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
+P + + SV + ALY+Y + GDL F KGD + + + E WW A + Q G+IPSNYV+ D E WF + +A+R+LL GN G+++IR S +R +LS+R DP+ VKHYKIRTLDNGG+YIS R F ++ L++HY + DGLC LT P P+ KP ++ E+ R + L +KLG G FGEVW+ +N +VAVK M+P M + F+ EA LM +L H ++V++ V T+ PIYIITE M KG+LL+FL+ +EG ++ L ++ +QIAEGMAY+E ++HRDLRAANILV+ L K+ADFGLARI ED EY A G KFPIKWTAPEA F++KSDVWSFG+L+ EII+YGRTPY G N +V+ + +GYR+ + CP ELY+IML CW +E+RPTF +L+ E++ ATE QY
Sbjct: 43 LPGPNSSEGESVAI-ALYDYEAIHEGDLGFKKGDRLKILEESGE-WWKAKSISSGQEGFIPSNYVAKDT---LETEDWFFKGVSRKDAERQLLASGNKTGSFMIRDSETTRGSYSLSVRDHDPQAG-DTVKHYKIRTLDNGGFYISPRITFRTLQELVSHYKKQGDGLCQSLTSPCLSPKPEKP-WEKDAWEIPRSSLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFMMEANLMKRLQHDKLVRLNAVVTKE--EPIYIITEFMEKGSLLDFLKSDEGNRVQLPKLIDFSAQIAEGMAYIEQNNYIHRDLRAANILVNKALVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDVWSFGILLTEIISYGRTPYPGMTNPEVIRSLEKGYRMQRLES----CPTELYDIMLDCWKNKAEERPTFDYLQSILEDFFTATESQY 494 HSP 2 Score: 62.7734 bits (151), Expect = 7.734e-10 Identity = 41/116 (35.34%), Postives = 62/116 (53.45%), Query Frame = 2
Query: 254 PPKGVKHTTSTVPNSSPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
P G K PNSS V + ALY Y+ + GDL F KGD L + + WW A+ + G+IPSNYV D + + + FF+ ++ +A+++LL G G+++IR S
Sbjct: 34 PTSGKKTPKLPGPNSSEGESVAI-ALYDYEAIHEGDLGFKKGDRLKILEESGE-WWKAKSISSGQEGFIPSNYVAKD--TLETEDWFFKGVSRKDAERQLLASGNKTGSFMIRDSE 145
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: hck (HCK proto-oncogene, Src family tyrosine kinase [Source:NCBI gene;Acc:101163900]) HSP 1 Score: 409.838 bits (1052), Expect = 9.880e-135 Identity = 215/450 (47.78%), Postives = 290/450 (64.44%), Query Frame = 1
Query: 748 ALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWF--DIIHSEADRKLLLMGNPKGTYIIRPSSDSRNC-ALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEP--FPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITED-EYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
ALY+Y + GDL F KGD + + + E WW A + Q G+IPSNYV+ D E WF + +A+R+LL GN G+++IR S +R +LS+R DP+ VKHYKIRTLDNGG+YIS R F ++ L++HY + DGLC LT P P+ KP ++ E+ R + L +KLG G FGEVW+ +N +VAVK M+P M + F+ EA LM +L H ++V++ V T+ PIYIITE M KG+LL+FL+ +EG ++ L ++ +QIAEGMAY+E ++HRDLRAANILV+ L K+ADFGLARI ED EY A G KFPIKWTAPEA F++KSDVWSFG+L+ EII+YGRTPY G N +V+ + +GYR+ + CP ELY+IML CW +E+RPTF +L+ E++ ATE QY
Sbjct: 63 ALYDYEAIHEGDLGFKKGDRLKILEESGE-WWKAKSISSGQEGFIPSNYVAKD---TLETEDWFFKGVSRKDAERQLLASGNKTGSFMIRDSETTRGSYSLSVRDHDPQAG-DTVKHYKIRTLDNGGFYISPRITFRTLQELVSHYKKQGDGLCQSLTSPCLSPKPEKP-WEKDAWEIPRSSLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFMMEANLMKRLQHDKLVRLNAVVTKE--EPIYIITEFMEKGSLLDFLKSDEGNRVQLPKLIDFSAQIAEGMAYIEQNNYIHRDLRAANILVNKALVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDVWSFGILLTEIISYGRTPYPGMTNPEVIRSLEKGYRMQRLES----CPTELYDIMLDCWKNKAEERPTFDYLQSILEDFFTATESQY 500 HSP 2 Score: 58.5362 bits (140), Expect = 1.866e-8 Identity = 33/92 (35.87%), Postives = 53/92 (57.61%), Query Frame = 2
Query: 326 ALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFE-INHIEADKKLLLMGYSPGTYIIRPSS 598
ALY Y+ + GDL F KGD L + + WW A+ + G+IPSNYV D + + + FF+ ++ +A+++LL G G+++IR S
Sbjct: 63 ALYDYEAIHEGDLGFKKGDRLKILEESGE-WWKAKSISSGQEGFIPSNYVAKD--TLETEDWFFKGVSRKDAERQLLASGNKTGSFMIRDSE 151
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000060646.1 (SMESG000060646.1) HSP 1 Score: 1005.74 bits (2599), Expect = 0.000e+0 Identity = 491/492 (99.80%), Postives = 492/492 (100.00%), Query Frame = 1
Query: 619 MGNCVKRXXXXXXXXXXXXXVDNYIFDTIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
MGNCVKRPTSNPSTS+PQQPVDNYIFDTIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS
Sbjct: 1 MGNCVKRPTSNPSTSNPQQPVDNYIFDTIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 492 HSP 2 Score: 135.576 bits (340), Expect = 1.917e-33 Identity = 65/102 (63.73%), Postives = 78/102 (76.47%), Query Frame = 2
Query: 314 VKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD---CAI 610
V+VRALY Y+I N GDL+F KGDI+ V+S++N+PWW A H GYIPSNYV VDDG+PTS E +F+I H EAD+KLLLMG GTYIIRPSSD CA+
Sbjct: 40 VRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCAL 141
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000060646.1 (SMESG000060646.1) HSP 1 Score: 960.288 bits (2481), Expect = 0.000e+0 Identity = 471/491 (95.93%), Postives = 477/491 (97.15%), Query Frame = 1
Query: 619 MGNCVKRXXXXXXXXXXXXXVDNYIFDTIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDD 2091
MGNCVKRPTSNPSTS+PQQPVDNYIFDTIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGF N KVLE VSRGYRLPNP G +I CP LYNIMLSCWDA SEKRPTFS++KD F+N+ IA E YGMDD
Sbjct: 1 MGNCVKRPTSNPSTSNPQQPVDNYIFDTIPQETTMQVASVRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFPNNKVLESVSRGYRLPNPHGERIVCPRLLYNIMLSCWDAISEKRPTFSYMKDVFDNFAIANEPLYGMDD 491 HSP 2 Score: 135.191 bits (339), Expect = 2.568e-33 Identity = 65/102 (63.73%), Postives = 78/102 (76.47%), Query Frame = 2
Query: 314 VKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD---CAI 610
V+VRALY Y+I N GDL+F KGDI+ V+S++N+PWW A H GYIPSNYV VDDG+PTS E +F+I H EAD+KLLLMG GTYIIRPSSD CA+
Sbjct: 40 VRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCAL 141
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000060646.1 (SMESG000060646.1) HSP 1 Score: 884.789 bits (2285), Expect = 0.000e+0 Identity = 420/453 (92.72%), Postives = 432/453 (95.36%), Query Frame = 1
Query: 736 VRVRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 2094
V+VRALY Y+I N GDL+F KGDI+ V+S++N+PWW A H GYIPSNYV VDDG+PTS E +F+I H EAD+KLLLMG GTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS
Sbjct: 28 VKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNGGYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQYGMDDS 480 HSP 2 Score: 255.373 bits (651), Expect = 3.293e-76 Identity = 124/129 (96.12%), Postives = 125/129 (96.90%), Query Frame = 2
Query: 233 MGKRHSKPPKGVKHTTSTVPNSSPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD---CAI 610
MGKRHSKPPKGVKH TSTVPNSSPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD CA+
Sbjct: 1 MGKRHSKPPKGVKHKTSTVPNSSPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSDSRNCAL 129
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000045588.1 (SMESG000045588.1) HSP 1 Score: 659.448 bits (1700), Expect = 0.000e+0 Identity = 307/447 (68.68%), Postives = 366/447 (81.88%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNG-GYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
VRAL++Y + DL F KGD+M +SSD++E WW A H +TGYIPSNYV +DDG+P+SHE W+DI H EAD+KLL MGNP GTYIIRP SDS++ ALS+RHFD +N+YVVKHYKIRTLDN G+YIS+R+ FP+I +LI +Y +TDGLCC+LT P++HKPP QF++IEV+R CI L R LGNGSFGEV+LGKWN+ +EVAVK ++PN MD F+ EA+LMHKL+HPRIVQILGVCT+P P++IITELMA GALLN+LR EGQKL L +ML M+SQIAEGMAYLES+ FVHRDLRAANILV +DLSVKVADFGLAR+T+D Y AD GTKFPIKWTAPEAG++R FSVKSDVWSFGVLM+EI+TYGRTPY G N +VL+EVS+GYRLPNP GGKI CP ELY I L CWDA E RPTFS L+D FE++ I E QY
Sbjct: 69 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 515 HSP 2 Score: 127.872 bits (320), Expect = 9.203e-31 Identity = 59/108 (54.63%), Postives = 81/108 (75.00%), Query Frame = 2
Query: 278 TSTVPNSSPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD 601
+S +P N VRAL++Y+ R+ DL F+KGD+++++S+M++ WW+A H+ T GYIPSNYVV+DDGSP+S EG+++I H EADKKLL MG GTYIIRP SD
Sbjct: 55 SSPIPPVMYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSD 162
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000029204.1 (SMESG000029204.1) HSP 1 Score: 659.448 bits (1700), Expect = 0.000e+0 Identity = 307/447 (68.68%), Postives = 366/447 (81.88%), Query Frame = 1
Query: 742 VRALYNYNIHNAGDLAFCKGDIMVVSSDLNEPWWFATHQGNFQTGYIPSNYVSVDDGTPTSHEAWFDIIHSEADRKLLLMGNPKGTYIIRPSSDSRNCALSIRHFDPERNFYVVKHYKIRTLDNG-GYYISHRTPFPDIRTLIAHYTQHTDGLCCRLTEPFPRQHKPPFQFREIEVNRKCITLVRKLGNGSFGEVWLGKWNDIIEVAVKMMRPNCMDSDTFLGEAQLMHKLHHPRIVQILGVCTEPAGSPIYIITELMAKGALLNFLREEEGQKLTLQDMLLMLSQIAEGMAYLESKCFVHRDLRAANILVSDDLSVKVADFGLARITEDEYLADPGTKFPIKWTAPEAGLKRVFSVKSDVWSFGVLMFEIITYGRTPYAGFQNCKVLEEVSRGYRLPNPQGGKIKCPGELYNIMLSCWDATSEKRPTFSFLKDTFENYTIATERQY 2079
VRAL++Y + DL F KGD+M +SSD++E WW A H +TGYIPSNYV +DDG+P+SHE W+DI H EAD+KLL MGNP GTYIIRP SDS++ ALS+RHFD +N+YVVKHYKIRTLDN G+YIS+R+ FP+I +LI +Y +TDGLCC+LT P++HKPP QF++IEV+R CI L R LGNGSFGEV+LGKWN+ +EVAVK ++PN MD F+ EA+LMHKL+HPRIVQILGVCT+P P++IITELMA GALLN+LR EGQKL L +ML M+SQIAEGMAYLES+ FVHRDLRAANILV +DLSVKVADFGLAR+T+D Y AD GTKFPIKWTAPEAG++R FSVKSDVWSFGVLM+EI+TYGRTPY G N +VL+EVS+GYRLPNP GGKI CP ELY I L CWDA E RPTFS L+D FE++ I E QY
Sbjct: 69 VRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSDSKHYALSVRHFDTTKNYYVVKHYKIRTLDNNLGFYISNRSKFPNISSLIKYYQTNTDGLCCKLTLSCPQRHKPPIQFKDIEVSRDCIRLERVLGNGSFGEVYLGKWNNSVEVAVKQLKPNSMDRSRFIAEAELMHKLNHPRIVQILGVCTQPPEQPVFIITELMANGALLNYLRSPEGQKLRLNEMLDMMSQIAEGMAYLESRNFVHRDLRAANILVDEDLSVKVADFGLARVTDDVYNADTGTKFPIKWTAPEAGMQRRFSVKSDVWSFGVLMYEIVTYGRTPYPGIPNRQVLDEVSKGYRLPNPAGGKIVCPDELYAIKLKCWDAYPENRPTFSHLQDIFEHWEINAESQY 515 HSP 2 Score: 127.872 bits (320), Expect = 9.203e-31 Identity = 59/108 (54.63%), Postives = 81/108 (75.00%), Query Frame = 2
Query: 278 TSTVPNSSPNLGVKVRALYTYDIRNPGDLSFAKGDILFVTSNMNDPWWVARHSRTDAVGYIPSNYVVVDDGSPTSIEGFFEINHIEADKKLLLMGYSPGTYIIRPSSD 601
+S +P N VRAL++Y+ R+ DL F+KGD+++++S+M++ WW+A H+ T GYIPSNYVV+DDGSP+S EG+++I H EADKKLL MG GTYIIRP SD
Sbjct: 55 SSPIPPVMYNQRPTVRALFSYEARHTDDLEFSKGDLMYISSDMSEAWWLALHATTKKTGYIPSNYVVLDDGSPSSHEGWYDITHKEADKKLLRMGNPIGTYIIRPCSD 162 The following BLAST results are available for this feature:
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Tyrosine-protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017128 ID=SMED30017128|Name=Tyrosine-protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2364bpback to top protein sequence of SMED30017128-orf-1 >SMED30017128-orf-1 ID=SMED30017128-orf-1|Name=SMED30017128-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=493bp MGNCVKRPTSNPSTSSPQQPVDNYIFDTIPQETTMQVASVRVRALYNYNIback to top protein sequence of SMED30017128-orf-2 >SMED30017128-orf-2 ID=SMED30017128-orf-2|Name=SMED30017128-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=134bp MGKRHSKPPKGVKHTTSTVPNSSPNLGVKVRALYTYDIRNPGDLSFAKGDback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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