Integrase catalytic domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017119 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of Integrase catalytic domain-containing protein vs. TrEMBL
Match: A0A2B4RBS5 (Uncharacterized protein OS=Stylophora pistillata OX=50429 GN=AWC38_SpisGene22069 PE=4 SV=1) HSP 1 Score: 88.1965 bits (217), Expect = 5.069e-14 Identity = 91/325 (28.00%), Postives = 146/325 (44.92%), Query Frame = 1 Query: 1393 WLREPSFLKEKVPGRREITNI*TTLRSDTDKRALL*QRKSMYRNDHFGFNKLL--------------EYSRWINLTRA-----RFYENSRLPMNKRYIGDMTVLEIEDPEFK*IQEDQKVEFKEEWNCRSKNLHKMIESKNEV*RVNTK*------KSFGQCELA*I--NNKIYRIILSGKSWVTWLIA------TEHYGRLEYLTPKLNEKYLVVGGRPFPEK---EIHNLSKTKCKT*LTNHGIIAFFPSKLTFYRIHK*INNKAADYVGVIITTQSRGNRQTKKYPCLFICLITRVIPLEMLYRLGTDSFIHSFKRFIEQRG 2259 W PS+LKEK P I + T SDT+ R + + G ++++ +S W+ LTR RF +N LP +R G++TV EI+D E + I+ Q++ FKEE C + + K + +++ + + +S G+ E A + Y IIL K WVT LI H L+ ++ ++ R + E + + K K ++A P K+ + + A D+ G + Q RG R+ K+Y CLF CL +R + LE+ Y L TDSF+++F R +RG Sbjct: 214 WWEGPSYLKEK-PSEWPINKLTTVRASDTEVR----KSNKCQLDPSDGRDRMMVTIEGDGESRLEPKRFSSWLRLTRIQARIYRFLKNCLLPNGRRTRGELTVEEIQDAEIRIIKAAQRL-FKEE--CSALSSGKPLPMSSKLLTLKPRLDEDGVVRSDGRLENAEYLPYDVKYPIILPRKEWVTKLIVRWYHQQGNHPSGTHQTLAMLSSRFWLMQRREEIRECKGECYECRRRKAKA---AQQVMAPLP-KIRLKMPPRAFSRTAVDFGGPFMMIQGRGKRRAKRYLCLFTCLTSRALHLEIAYGLDTDSFLNAFCRMASRRG 526
BLAST of Integrase catalytic domain-containing protein vs. TrEMBL
Match: A0A2B4SD70 (Uncharacterized protein OS=Stylophora pistillata OX=50429 GN=AWC38_SpisGene8853 PE=4 SV=1) HSP 1 Score: 79.7221 bits (195), Expect = 3.252e-12 Identity = 41/108 (37.96%), Postives = 64/108 (59.26%), Query Frame = 1 Query: 880 EIWQQAGMETRKWVTNDGEVLETLPIEMISEFIHLDEKSDISVKTLGVVVWYASGDKFGFNIRRINKE-NISKRGFFSGLAKIFDPLVLDGAFLVRGKMLMQEIWIAG 1200 E+W +AGM RKW++N +VLE +P++ + LD+ SVKTLG ++W A F + KE ++KR F G+A +FDPL ++VR K+++QE+ G Sbjct: 195 ELWGRAGMHARKWLSNSPKVLEEIPVDDRASEADLDQGHLPSVKTLG-ILWLAEEGMFTYTAHPPGKEFQLTKRSFLKGIATLFDPLGFLAPYIVRAKIILQEMRTTG 301
BLAST of Integrase catalytic domain-containing protein vs. TrEMBL
Match: A0A2G8KMP0 (Integrase_H2C2 domain-containing protein OS=Stichopus japonicus OX=307972 GN=BSL78_13912 PE=4 SV=1) HSP 1 Score: 76.6406 bits (187), Expect = 6.284e-12 Identity = 54/151 (35.76%), Postives = 76/151 (50.33%), Query Frame = 1 Query: 1837 IILSGKSWVTWLIATEHYGRLEYLTPK------LNEKYLVVGGRPFPEKEIHNLSKT--KCKT*LTNHG--IIAFFPSKLTFYRIHK*INNKAADYVGVIITTQSRGNRQTKKYPCLFICLITRVIPLEMLYRLGTDSFIHSFKRFIEQRG 2259 IIL K VT LI EH+ +++ L+ KY ++GGR +EI T +CK G I+A P T + + + D+ G +T Q RG +TK+Y CLF C+ TR + LEM + L TDSFI+ RF +RG Sbjct: 27 IILPRKHPVTRLIVKEHHVEGKHIAGTNHTLALLSNKYWLIGGR----EEIREWENTCNECKRGKPRGGQQIMAPLPKSRTNVDTMRAFDKVSVDFAGQFLTKQGRGKIKTKRYLCLFTCMKTRAVHLEMAFGLDTDSFINCLYRFTSRRG 173
BLAST of Integrase catalytic domain-containing protein vs. TrEMBL
Match: A0A2B4RBG6 (Nucleotide-binding oligomerization domain-containing protein 2 OS=Stylophora pistillata OX=50429 GN=Nod2 PE=4 SV=1) HSP 1 Score: 82.0333 bits (201), Expect = 6.804e-12 Identity = 77/259 (29.73%), Postives = 119/259 (45.95%), Query Frame = 1 Query: 1555 YSRWINLTRA-----RFYENSRLPMNKRYIGDMTVLEIEDPEFK*IQEDQKVEF--------KEEWNCRSK--NLHKMIESKNEV*RVNTK*KSFGQCELA*INNKIYRIILSGKSWVTWLI------ATEHYGRLEYLTPKLNEKYLVVGGRPFP---EKEIHNLSKTKCKT*LTNHGIIAFFPSKLTFYRIHK*INNKAADYVGVIITTQSRGNRQTKKYPCLFICLITRVIPLEMLYRLGTDSFIHSFKRFIEQRG 2259 +S W L R RF +N R P +R GD+ + +IED + I++ Q+ F + E +SK L ++ + +V R N + E + + IIL KS+VT LI +H G L L+ ++ ++ GR EKE + + K K I+A P Y + A DY G IT Q+R R+ K+ CLF CL +R + +EM Y L TD+F+++F R + +RG Sbjct: 1501 FSSWTKLIRIQAWVHRFVDNCRSPNRER--GDLNLEKIEDIAVQVIKDAQRKAFPIEYLALQRRELPKKSKLLGLQPWLDEEGQV-RCN---RRLRYAEFL-PQDACFLIILPRKSYVTKLIDKHYHEKDDHAGGTNQLLAALSTRFWIISGREEICEWEKECNECRRRKAKA---AKQIMAPLPQIRLRYSLRA-FAQTAVDYGGPFITVQARRPRRQKRNLCLFTCLASRAVYVEMAYALDTDAFLNAFYRMVNRRG 1748
BLAST of Integrase catalytic domain-containing protein vs. TrEMBL
Match: A0A2B4SSQ9 (DUF5641 domain-containing protein OS=Stylophora pistillata OX=50429 GN=AWC38_SpisGene3220 PE=4 SV=1) HSP 1 Score: 79.337 bits (194), Expect = 7.015e-12 Identity = 43/108 (39.81%), Postives = 63/108 (58.33%), Query Frame = 1 Query: 880 EIWQQAGMETRKWVTNDGEVLETLPIEMISEFIHLDEKSDISVKTLGVVVWYASGDKFGFNIRR-INKENISKRGFFSGLAKIFDPLVLDGAFLVRGKMLMQEIWIAG 1200 E+W AGM RKW++N EVL+++P + + LD VKTLG V+W F F + + K + +KR F G+A +FDPL L + VR K+L+QE+W +G Sbjct: 19 ELWGSAGMYARKWLSNKLEVLQSIPSSDCATEVDLDSGELPQVKTLG-VLWSPVEYVFKFQVNQPAEKCDQTKRNFLKGIATLFDPLGLLTPYTVRAKILLQEMWASG 125
BLAST of Integrase catalytic domain-containing protein vs. Planmine SMEST
Match: SMESG000017840.1 (SMESG000017840.1) HSP 1 Score: 169.088 bits (427), Expect = 1.952e-53 Identity = 84/108 (77.78%), Postives = 93/108 (86.11%), Query Frame = 1 Query: 880 EIWQQAGMETRKWVTNDGEVLETLPIEMISEFIHLDEKSDISVKTLGVVVWYASGDKFGFNIRRINKENISKRGFFSGLAKIFDPLVLDGAFLVRGKMLMQEIWIAGS 1203 EIWQ GM+TRKW+TNDG+VLET+ IEM S+FI+LDEKSDISVKTLGVV WYAS DK GFN+RRINK ISKR S LAKIFDPL L GAFLVRGK+LMQEIWIAG+ Sbjct: 596 EIWQHVGMQTRKWLTNDGQVLETIQIEMRSKFINLDEKSDISVKTLGVV-WYASEDKLGFNVRRINKGKISKRELLSCLAKIFDPLGLAGAFLVRGKILMQEIWIAGT 702 HSP 2 Score: 52.7582 bits (125), Expect = 1.952e-53 Identity = 31/56 (55.36%), Postives = 34/56 (60.71%), Query Frame = 2 Query: 755 ISIFLAQLLTRCNPEQLHSKHST--------------MDSFGTWRKLIRIKNELIE 880 IS FLAQL+TR N E+ HSKH T MDSFGT + IRIKNELIE Sbjct: 541 ISPFLAQLVTRRNAEKFHSKHPTASDTIVNSTLMDYTMDSFGTTEETIRIKNELIE 596 HSP 3 Score: 29.261 bits (64), Expect = 1.952e-53 Identity = 17/28 (60.71%), Postives = 19/28 (67.86%), Query Frame = 3 Query: 696 KFHWE-GGNIE---FEILDFGLNIYPYF 767 +F WE GGNIE FE L FGLNI P+ Sbjct: 518 RFLWEEGGNIEGFEFERLVFGLNISPFL 545
BLAST of Integrase catalytic domain-containing protein vs. Planmine SMEST
Match: SMESG000022805.1 (SMESG000022805.1) HSP 1 Score: 99.7525 bits (247), Expect = 9.312e-22 Identity = 49/108 (45.37%), Postives = 74/108 (68.52%), Query Frame = 1 Query: 880 EIWQQAGMETRKWVTNDGEVLETLPIEMISEFIHLDEKSDISVKTLGVVVWYASGDKFGFNIRRINKENISKRGFFSGLAKIFDPLVLDGAFLVRGKMLMQEIWIAGS 1203 EIW +AGM T+KW++N +VLE +PIE + + + E+ +++KTLG+ W A+ D F F+++ E ++KR S +A+IFDPL AF+VRGKM+MQ IWI G+ Sbjct: 166 EIWNKAGMRTQKWMSNSKKVLENVPIENRAIKLDIKEEGSMTMKTLGLR-WVANLDVFEFSVKAFESETLTKRLLLSWIARIFDPLGFLAAFVVRGKMIMQSIWITGA 272
BLAST of Integrase catalytic domain-containing protein vs. Planmine SMEST
Match: SMESG000021004.1 (SMESG000021004.1) HSP 1 Score: 98.9821 bits (245), Expect = 4.595e-21 Identity = 48/108 (44.44%), Postives = 75/108 (69.44%), Query Frame = 1 Query: 880 EIWQQAGMETRKWVTNDGEVLETLPIEMISEFIHLDEKSDISVKTLGVVVWYASGDKFGFNIRRINKENISKRGFFSGLAKIFDPLVLDGAFLVRGKMLMQEIWIAGS 1203 EIW +AGM T+KW++N +VLE +PIE + + ++E+ +++KTLG+ W A+ D F F+++ E ++KR S +A+IFDPL AF+VRG+M+MQ IWI G+ Sbjct: 468 EIWNKAGMRTQKWMSNSTKVLENVPIENRAIKLDIEEEGSMTMKTLGLR-WVANLDVFEFSVKAFESETLTKRLLLSWIARIFDPLGFLAAFVVRGEMIMQSIWITGA 574
BLAST of Integrase catalytic domain-containing protein vs. Planmine SMEST
Match: SMESG000053711.1 (SMESG000053711.1) HSP 1 Score: 98.2117 bits (243), Expect = 1.475e-20 Identity = 48/108 (44.44%), Postives = 75/108 (69.44%), Query Frame = 1 Query: 880 EIWQQAGMETRKWVTNDGEVLETLPIEMISEFIHLDEKSDISVKTLGVVVWYASGDKFGFNIRRINKENISKRGFFSGLAKIFDPLVLDGAFLVRGKMLMQEIWIAGS 1203 EIW +AGM T+KW++N +VLE +PIE + + ++E+ +++KTLG+ W A+ D F F+++ E ++KR S +A+IFDPL AF+VRGK++MQ IWI G+ Sbjct: 563 EIWNKAGMRTQKWMSNSTKVLENVPIENRAIKLDIEEEGSMTMKTLGLR-WVANLDVFEFSVKAFESETLTKRLLLSWIARIFDPLGFLAAFVVRGKIIMQSIWIIGA 669 HSP 2 Score: 77.7962 bits (190), Expect = 2.589e-14 Identity = 53/156 (33.97%), Postives = 75/156 (48.08%), Query Frame = 1 Query: 1819 NNKIYRIILSGKSWVTWLI------ATEHYGRLEYLTPKLNEKYLVVGGRPFPEKEIHNLSKTKCKT*LTNHGIIAFFPSKLTFYRIHK*INNKAADYVGVIITTQSRGNRQTKKYPCLFICLITRVIPLEMLYRLGTDSFIHSFKRFIEQRGTKL 2268 NN Y IILS +SW+ LI +HY + + +LN +Y VV R +K I + + + I+A PS F + A D+ G T Q + K+Y CLF CL TR + LE+ Y L TD+FI +F RF+ +R L Sbjct: 923 NNTRYPIILSDESWIARLIIRGLHIKNKHYAGVNHTLGELNREYWVVCARWLIKKCIKGCFECRRRKAKGMEQIMATLPS-FRFQEPLQAFARIAVDFAGPFETIQGSAKTRQKRYMCLFTCLQTRAVHLEVAYALDTDAFILAFIRFMGRRRKPL 1077
BLAST of Integrase catalytic domain-containing protein vs. Planmine SMEST
Match: SMESG000058166.1 (SMESG000058166.1) HSP 1 Score: 97.4413 bits (241), Expect = 2.848e-20 Identity = 48/108 (44.44%), Postives = 73/108 (67.59%), Query Frame = 1 Query: 880 EIWQQAGMETRKWVTNDGEVLETLPIEMISEFIHLDEKSDISVKTLGVVVWYASGDKFGFNIRRINKENISKRGFFSGLAKIFDPLVLDGAFLVRGKMLMQEIWIAGS 1203 EIW +AGM T+KW++N +VLE +PIE + + ++E+ +++K LG+ W + D F F+I+ E ++KR S +A+IFDPL AF+VRGKM+MQ IWI G+ Sbjct: 1240 EIWNKAGMRTQKWMSNSTKVLENVPIENRAIKLDIEEEGSMTMKALGLR-WVTNLDVFEFSIKSFESETLTKRLLLSWIARIFDPLGFLAAFVVRGKMIMQSIWITGA 1346 The following BLAST results are available for this feature:
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Integrase catalytic domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017119 ID=SMED30017119|Name=Integrase catalytic domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2730bpback to top protein sequence of SMED30017119-orf-1 >SMED30017119-orf-1 ID=SMED30017119-orf-1|Name=SMED30017119-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=102bp METRKWVTNDGEVLETLPIEMISEFIHLDEKSDISVKTLGVVVWYASGDKback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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