Folate_rec domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30017009 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of Folate_rec domain-containing protein vs. TrEMBL
Match: C3YRH8 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_75612 PE=4 SV=1) HSP 1 Score: 152.91 bits (385), Expect = 2.231e-42 Identity = 70/162 (43.21%), Postives = 107/162 (66.05%), Query Frame = 3 Query: 192 KNPKGNVCTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVFGSNY-----RNGINCLLIIISIV 662 ++ + NVCTY+ RYSEP+ +L NCTW+ + CCRRTEVTSV + M+ L AT KC+ ++NY+MCYFCSP Q WY +N+ +C FC+ ++ C +A Y+G+ + S ++SG FC+AQ + ++ E+ C+ YDP VFG R GI L +++ ++ Sbjct: 25 ESHQNNVCTYYYDTRYSEPQGNLANCTWYSNNCCCRRTEVTSVASSMYPLFGATQKCRNVLNYMMCYFCSPEQYLWYYDNRVHICGRFCELVYRECGSASYEGVTIASAYESGWDFCQAQTYLVVD-ELPCFDYDPKVFGGGGIVKGNREGIVGLALLVLML 185
BLAST of Folate_rec domain-containing protein vs. TrEMBL
Match: A0A1S3JP76 (riboflavin-binding protein OS=Lingula unguis OX=7574 GN=LOC106174923 PE=4 SV=1) HSP 1 Score: 151.369 bits (381), Expect = 9.577e-42 Identity = 68/151 (45.03%), Postives = 104/151 (68.87%), Query Frame = 3 Query: 213 CTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVF--GSNYRNGINCLLIIISI 659 CTY+ PE+ L+NC+W+ +ACC+RTEVTSVF GM+ L +A+ KC+ +NYLMCYFCSP Q WY+ ++ VC FC ++ CKTAM+ G K+G+ +K+G++ CE Q F+ + S +C+ +DPTVF G + ++ + LL+++ I Sbjct: 36 CTYYGGTHVPSPENGLVNCSWYSTNACCKRTEVTSVFGGMYKLARASKKCQNRVNYLMCYFCSPEQHLWYQ-DQLHVCADFCDSIHFYCKTAMFSGEKIGTSYKNGKEICEGQKFKYVESNTNCFKFDPTVFDTGCSLKSSLITLLLVLGI 185
BLAST of Folate_rec domain-containing protein vs. TrEMBL
Match: A0A433SXA2 (Folate_rec domain-containing protein OS=Elysia chlorotica OX=188477 GN=EGW08_018293 PE=4 SV=1) HSP 1 Score: 150.214 bits (378), Expect = 3.655e-41 Identity = 74/181 (40.88%), Postives = 109/181 (60.22%), Query Frame = 3 Query: 117 ILAIQVSFVISPNENFNEINFHSIAKNPKGNVCTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVFGSNYRNGINCLLIIISI 659 IL+ V+ E E N +G C+YF + R E L+NCTW++ ACC+RTEVTSVF M L+ AT C+ +NYLMC+FCSP Q ++Y++NK VCL +C++L++ CK A + + +G + +G FCEAQNF+ + + C+ +DP VFGS+ + +LII I Sbjct: 19 ILSHGVTLASDDGETDAEGNPLLFEAEDEGQKCSYFYNERSPTNEGGLVNCTWYKTKACCKRTEVTSVFAAMDPLYGATKLCRNYINYLMCFFCSPDQGKFYKSNKVNVCLDYCESLYEECKNAGFSNMLIGEAYANGTSFCEAQNFEVVEN-ADCFKFDPNVFGSSVKMVPLSILIIFMI 198
BLAST of Folate_rec domain-containing protein vs. TrEMBL
Match: A7RPJ5 (Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g239793 PE=4 SV=1) HSP 1 Score: 149.828 bits (377), Expect = 3.945e-41 Identity = 66/139 (47.48%), Postives = 99/139 (71.22%), Query Frame = 3 Query: 201 KGNVCTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNS-EMHCYGYDPTVFGS 614 + + CTY+ S R E SL NCTWFR+ +CCR TEVTSVF GM AL++A+ C+ MNYLMCYFCSP Q +WY+N++ VC S C +++ CK + ++G ++G+++ +G++FCEAQ F +NS + C+ +D +FG+ Sbjct: 29 RASQCTYYGSGRVPEEAYSLSNCTWFRERSCCRHTEVTSVFKGMMALNEASQDCRNHMNYLMCYFCSPEQERWYKNSRLHVCESLCDAVYEKCKDSSFQGKEIGAEYSNGKEFCEAQFFHVVNSKDQECFDFDSGLFGT 167
BLAST of Folate_rec domain-containing protein vs. TrEMBL
Match: A0A1I8HSL7 (Folate_rec domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017771g3 PE=4 SV=1) HSP 1 Score: 147.902 bits (372), Expect = 3.836e-40 Identity = 63/133 (47.37%), Postives = 91/133 (68.42%), Query Frame = 3 Query: 213 CTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFA-LHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVF 608 CT+FA RYS PESSL+NC W+ ++ACC+R EVTSVF+ + + L + +C M+ YL+CYFCSP Q W+R+NK VC SFC +++ +C++A+ G++ G FK+GE FC NF + C+ +DPT F Sbjct: 48 CTFFAGTRYSVPESSLVNCYWYNRNACCKRIEVTSVFSSLLSKLEGQSRRCYDMLRYLLCYFCSPEQHFWFRDNKVFVCKSFCDDIYSHCRSAVMNGLEFGKAFKNGEDFCRGNNFAVQEDNVACFAFDPTQF 180
BLAST of Folate_rec domain-containing protein vs. Ensembl Nematostella
Match: EDO46522 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPJ5]) HSP 1 Score: 149.828 bits (377), Expect = 5.456e-45 Identity = 66/139 (47.48%), Postives = 99/139 (71.22%), Query Frame = 3 Query: 201 KGNVCTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNS-EMHCYGYDPTVFGS 614 + + CTY+ S R E SL NCTWFR+ +CCR TEVTSVF GM AL++A+ C+ MNYLMCYFCSP Q +WY+N++ VC S C +++ CK + ++G ++G+++ +G++FCEAQ F +NS + C+ +D +FG+ Sbjct: 29 RASQCTYYGSGRVPEEAYSLSNCTWFRERSCCRHTEVTSVFKGMMALNEASQDCRNHMNYLMCYFCSPEQERWYKNSRLHVCESLCDAVYEKCKDSSFQGKEIGAEYSNGKEFCEAQFFHVVNSKDQECFDFDSGLFGT 167
BLAST of Folate_rec domain-containing protein vs. Ensembl Nematostella
Match: EDO27250 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T9S3]) HSP 1 Score: 113.235 bits (282), Expect = 7.067e-31 Identity = 55/152 (36.18%), Postives = 91/152 (59.87%), Query Frame = 3 Query: 207 NVCTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSE-MHCYGYDPTVFGSNYRNGINCLLIIISI 659 N C YF +NR P+ +L NCTW++++ACC E+ S+ + L A ++C NYLMCY C+PYQ+ +Y+N + VC FC +F +C A KG ++ S +KSGE+FCE++ F + + +C+ ++ G+ I L ++++I Sbjct: 39 NYCPYF-NNRAPSPQPNLRNCTWYKENACCLPHELDSILEAIAPLTGANNRCLRAFNYLMCYVCAPYQNMFYKNERLTVCRDFCDTIFQSCGDAFLKGSRISSAYKSGEEFCESRKFIVADGKSKNCFTSIQSISGA-VGVKIRLLTVVVTI 188
BLAST of Folate_rec domain-containing protein vs. Ensembl Nematostella
Match: EDO36987 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH49]) HSP 1 Score: 100.138 bits (248), Expect = 2.018e-24 Identity = 46/131 (35.11%), Postives = 75/131 (57.25%), Query Frame = 3 Query: 213 CTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQT--LNSEMHCYGYDP 599 C YF NR + +L NCTW+ +++CC +E+ F + + KA + C +NYL CY C+P Q+ ++R + VC FC ++ CK A KG+ +G + +G +FCE + F+ NS+ C+ +DP Sbjct: 215 CPYF-KNRGPSRQDNLRNCTWYTENSCCHDSEIEFAFAQLTPIPKAGESCVKQLNYLYCYICAPNQNTFFRRSTLTVCEEFCNRIYSACKKAYLKGMMIGDMYSNGREFCEGRRFEVSDKNSKQGCFDFDP 344
BLAST of Folate_rec domain-containing protein vs. Planmine SMEST
Match: SMESG000047698.1 (SMESG000047698.1) HSP 1 Score: 414.846 bits (1065), Expect = 5.888e-149 Identity = 200/201 (99.50%), Postives = 201/201 (100.00%), Query Frame = 3 Query: 87 MQLNAYILANILAIQVSFVISPNENFNEINFHSIAKNPKGNVCTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVFGSNYRNGINCLLIIISIVYNCCDLFIY 689 MQLNAYILANILAI+VSFVISPNENFNEINFHSIAKNPKGNVCTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVFGSNYRNGINCLLIIISIVYNCCDLFIY Sbjct: 1 MQLNAYILANILAIRVSFVISPNENFNEINFHSIAKNPKGNVCTYFASNRYSEPESSLINCTWFRKDACCRRTEVTSVFTGMFALHKATDKCKYMMNYLMCYFCSPYQSQWYRNNKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVFGSNYRNGINCLLIIISIVYNCCDLFIY 201
BLAST of Folate_rec domain-containing protein vs. Planmine SMEST
Match: SMESG000047698.1 (SMESG000047698.1) HSP 1 Score: 180.259 bits (456), Expect = 1.108e-57 Identity = 86/87 (98.85%), Postives = 87/87 (100.00%), Query Frame = 3 Query: 429 NKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVFGSNYRNGINCLLIIISIVYNCCDLFIY 689 +KTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVFGSNYRNGINCLLIIISIVYNCCDLFIY Sbjct: 27 SKTVVCLSFCQNLFDNCKTAMYKGIKLGSKFKSGEKFCEAQNFQTLNSEMHCYGYDPTVFGSNYRNGINCLLIIISIVYNCCDLFIY 113 HSP 2 Score: 49.6766 bits (117), Expect = 1.115e-7 Identity = 24/24 (100.00%), Postives = 24/24 (100.00%), Query Frame = 2 Query: 359 MQIYDELPYVLFLQSISISMVSKQ 430 MQIYDELPYVLFLQSISISMVSKQ Sbjct: 1 MQIYDELPYVLFLQSISISMVSKQ 24 The following BLAST results are available for this feature:
BLAST of Folate_rec domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Folate_rec domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of Folate_rec domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Folate_rec domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30017009 ID=SMED30017009|Name=Folate_rec domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=811bpback to top protein sequence of SMED30017009-orf-1 >SMED30017009-orf-1 ID=SMED30017009-orf-1|Name=SMED30017009-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=202bp MQLNAYILANILAIQVSFVISPNENFNEINFHSIAKNPKGNVCTYFASNRback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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