O-methyltransferase

Overview
NameO-methyltransferase
Smed IDSMED30016967
Length (bp)783
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of O-methyltransferase (SMED30016967) t-SNE clustered cells

Violin plots show distribution of expression levels for O-methyltransferase (SMED30016967) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of O-methyltransferase (SMED30016967) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for O-methyltransferase (SMED30016967) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30016967

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30016967SMESG000063332.1 Contig1726GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
pharynxSMED30016967SMESG000063332.1 dd_Smed_v4_1794_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30016967SMESG000063332.1 dd_Smed_v4_1794_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30016967SMESG000063332.1 dd_Smed_v4_1794_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30016967SMESG000063332.1 dd_Smed_v4_1794_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30016967SMESG000063332.1 dd_Smed_v4_1794_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30016967SMESG000063332.1 dd_Smed_v4_1794_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30016967SMESG000063332.1 Contig42538newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30016967SMESG000063332.1 Contig42538uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of O-methyltransferase vs. Ensembl Human
Match: COMTD1 (catechol-O-methyltransferase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26309])

HSP 1 Score: 163.31 bits (412), Expect = 8.996e-49
Identity = 84/210 (40.00%), Postives = 127/210 (60.48%), Query Frame = 2 
Query:   77 KIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            ++  Y+   S++   + + L   T+E      + + E+ Q L+N+ R+I AKK LD+G FTGYS+L +A  LP +G+V   ++ D    +   P W++     KI   L PA+E L++L+A G +GTFD A +DADK     YYE CL+L+RP G++A+  VLW GKVL     D     +R LNE+++ D R  IS+L +GDG+T+AFK
Sbjct:   53 RLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALALALALPADGRVVTCEV-DAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFK 261
[Close]
BLAST of O-methyltransferase vs. Ensembl Human
Match: COMTD1 (catechol-O-methyltransferase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26309])

HSP 1 Score: 161.384 bits (407), Expect = 4.515e-48
Identity = 82/189 (43.39%), Postives = 118/189 (62.43%), Query Frame = 2 
Query:  140 EKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            E T+E      + + E+ Q L+N+ R+I AKK LD+G FTGYS+L +A  LP +G+V   ++ D    +   P W++     KI   L PA+E L++L+A G +GTFD A +DADK     YYE CL+L+RP G++A+  VLW GKVL     D     +R LNE+++ D R  IS+L +GDG+T+AFK
Sbjct:   72 ELTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALALALALPADGRVVTCEV-DAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFK 259
[Close]
BLAST of O-methyltransferase vs. Ensembl Celegans
Match: comt-4 (Catechol-O-MethylTransferase family [Source:UniProtKB/TrEMBL;Acc:Q965W4])

HSP 1 Score: 181.8 bits (460), Expect = 6.892e-57
Identity = 98/227 (43.17%), Postives = 138/227 (60.79%), Query Frame = 2 
Query:   38 LIMTTKTYRKGLDKIVDYITEHSVKFSESQKWLIEKTM-ELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKK-GGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYK-DEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            + +  K+Y +  D +V Y  EH+   +  Q  L ++T+    +SGMLG+ E L F  N  + +GAK+ LD+G FTG S+L  A  +P++G+V+ FDI     + F  P   K      KI    GP +E L+KLIADG SGTFDFAFIDADK  Y +YYE C+ L+R  G+I +DN LW G V D   + D  T AI ++N+K+  DDR   ++L +GDG+ +AFKK
Sbjct:    1 MSIVAKSYEESADPVVAYCAEHTAVQTPLQAELQKETLTNAPHSGMLGAPEVLTFGENFIKFLGAKRVLDVGTFTGASALAWALAVPDDGEVFTFDIDHANYRKFGVPILSKCEKTFKKIKPVEGPGVESLDKLIADGQSGTFDFAFIDADKANYSNYYEKCVSLLRKGGVIFVDNSLWDGAVCDPAKRTDPRTAAIHEMNDKIYQDDRTYSALLNLGDGIHMAFKK 227
[Close]
BLAST of O-methyltransferase vs. Ensembl Celegans
Match: comt-5 (Catechol-O-MethylTransferase family [Source:UniProtKB/TrEMBL;Acc:Q8WTM3])

HSP 1 Score: 180.644 bits (457), Expect = 2.197e-56
Identity = 100/233 (42.92%), Postives = 139/233 (59.66%), Query Frame = 2 
Query:   38 LIMTTKTYRKGLDKIVDYITEHSVKFSESQKWLIEKTM-ELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDF-------CEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYK-DEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            + +  K+Y K  D +V Y +EH+V  +  Q  L  +T+    ++GMLG+ E L F  N  ++ G K+ LD+G FTG S+L  A  +P++G+VY FDI       F       CE  +KK      I    GP +E L+KLIADG SGTFDFAFIDA+KT Y  YYE C+ L+RP G+I +DN L GG V D   + D +  AI ++N+K+  DDR   ++L +GDG  +AFKK
Sbjct:    1 MSVVAKSYHKDADPVVAYCSEHTVVQAPLQVELQNETLANAPHAGMLGAPEVLTFGQNFIKMFGGKRALDVGTFTGASALAWALAVPDDGEVYTFDIDHTNYHKFGVPILSKCEKTFKK------IKPVEGPGVESLDKLIADGQSGTFDFAFIDAEKTSYPAYYEKCVTLLRPGGVIFVDNSLRGGSVADEKRREDPNCRAIHEMNDKIYQDDRTYSALLNLGDGTHVAFKK 227
[Close]
BLAST of O-methyltransferase vs. Ensembl Celegans
Match: comt-3 (Catechol-O-MethylTransferase family [Source:UniProtKB/TrEMBL;Acc:Q965W3])

HSP 1 Score: 164.081 bits (414), Expect = 5.358e-50
Identity = 96/228 (42.11%), Postives = 136/228 (59.65%), Query Frame = 2 
Query:   53 KTYRKGLDKIVDYITEHSVKFSESQKWLIEKTME-LNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDF-------CEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDE-DTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            K+Y K  D ++ Y +EH+   S  Q  L+++T++    S MLG+ E L F  N  R  G ++ +D+G +TG S+L  A  +P++G+V+ FDI     K F       CE  +KK      I    G A++GL+KLIADG SGTFDFAFIDADK  Y +YY+  + L+R  G+I +DN LW G V D   + E  TVAI + N+K+  DDR   +++ +GDG  IAFKK
Sbjct:    6 KSY-KSSDPVIAYCSEHTTIQSPLQAELLKETLDNAPMSMMLGAPEVLTFGQNFIRSFGGRRVIDVGTYTGASALAWALAVPDDGEVFTFDIDHTNYKKFGVPIISKCEKTFKK------IRAIEGSALDGLDKLIADGQSGTFDFAFIDADKVNYSNYYDRAVTLLRKGGVIFVDNSLWNGSVCDPARRTEPSTVAIHQANDKIFKDDRTYSALINLGDGTHIAFKK 226
[Close]
BLAST of O-methyltransferase vs. Ensembl Celegans
Match: comt-2 (Catechol-O-MethylTransferase family [Source:UniProtKB/TrEMBL;Acc:Q9XXH0])

HSP 1 Score: 156.762 bits (395), Expect = 3.020e-47
Identity = 95/211 (45.02%), Postives = 122/211 (57.82%), Query Frame = 2 
Query:   89 YITEHSVKFSESQKWLIEKTMELNNSGM-LGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPE-NGKVYAFDITDEYLKDFCEPAWKK-GGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVL-DLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            Y +EH+   SE Q  L   T++     M LG+ E   F  N  R  G K+ LDIG FTG S+L  A  +P+  G+V  FDI     K +  P   K      KI    GPA+E L+KLIADG SG+FDFAFIDADKT Y  YY+ C+ L+R  G+I +DN LW G V  +    DE +VAI + NEK+  DDR   ++L +GDG  +AFKK
Sbjct:    7 YCSEHTTIESELQAELRRATIDSVPMAMILGAPEVFTFGQNFIRSFGGKRVLDIGTFTGASALAWALAVPDGTGEVLTFDINLSDYKKYGVPIISKCKKTFKKIRAIEGPALENLDKLIADGQSGSFDFAFIDADKTNYSKYYDRCVTLLRKGGVIFVDNCLWDGSVCQETTRTDESSVAIHEANEKIFHDDRTYSAILNLGDGTHVAFKK 217
[Close]
BLAST of O-methyltransferase vs. Ensembl Celegans
Match: comt-3 (Catechol-O-MethylTransferase family [Source:UniProtKB/TrEMBL;Acc:Q965W3])

HSP 1 Score: 151.369 bits (381), Expect = 1.420e-45
Identity = 85/190 (44.74%), Postives = 115/190 (60.53%), Query Frame = 2 
Query:  164 SGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDF-------CEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDE-DTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            S MLG+ E L F  N  R  G ++ +D+G +TG S+L  A  +P++G+V+ FDI     K F       CE  +KK      I    G A++GL+KLIADG SGTFDFAFIDADK  Y +YY+  + L+R  G+I +DN LW G V D   + E  TVAI + N+K+  DDR   +++ +GDG  IAFKK
Sbjct:    2 SMMLGAPEVLTFGQNFIRSFGGRRVIDVGTYTGASALAWALAVPDDGEVFTFDIDHTNYKKFGVPIISKCEKTFKK------IRAIEGSALDGLDKLIADGQSGTFDFAFIDADKVNYSNYYDRAVTLLRKGGVIFVDNSLWNGSVCDPARRTEPSTVAIHQANDKIFKDDRTYSALINLGDGTHIAFKK 185
[Close]
BLAST of O-methyltransferase vs. Ensembl Zebrafish
Match: comtd1 (catechol-O-methyltransferase domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-030131-1072])

HSP 1 Score: 190.66 bits (483), Expect = 2.489e-59
Identity = 92/216 (42.59%), Postives = 149/216 (68.98%), Query Frame = 2 
Query:   62 RKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
             +G D ++ Y+  +S++       L  +TME   + M+ + E+ Q ++N+ ++I A KT++IG++TGY++L++A V+PENG+V A +I ++Y+K   +P + + GV +KI   L PA+E L++L++ G +G +DF FIDADK  Y  YYE  L+L+R  G++AIDNVLWGG+V++    D  + AI KLN+KL  D+R D+SML +GDG+T+A K+
Sbjct:   72 HEGDDPLLQYVVNNSLREHPVLTKLRLRTMEDARNVMMVASEQAQLMANLAKLIEANKTIEIGLYTGYNALSLALVVPENGRVVACEINEDYVK-IGKPFFAEAGVENKIDIRLKPAVETLDELLSAGEAGMYDFVFIDADKKNYETYYEKSLQLVRKGGIVAIDNVLWGGRVINPAEDDLSSQAIDKLNKKLHKDERIDLSMLTVGDGLTLAIKR 286
[Close]
BLAST of O-methyltransferase vs. Ensembl Zebrafish
Match: zgc:113054 (zgc:113054 [Source:ZFIN;Acc:ZDB-GENE-050320-9])

HSP 1 Score: 122.479 bits (306), Expect = 1.835e-31
Identity = 79/226 (34.96%), Postives = 125/226 (55.31%), Query Frame = 2 
Query:   68 GLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEEL--------------QFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACL--KLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTI 697
            GLD   +Y+ + S K SE    L  K++  + + +   G+ L              Q L  +  +  AK+ L+IG+FTGY +L++A  LPENG++ A ++ + YLKDF +P + K     KI+   GPA++ L +L A G    FD  FIDADK  Y++YY+  L   L+R +G+I +DN L+ G+V   +  DE   A+R  N+ +  D R +  ++ + DG+TI
Sbjct:   48 GLD---EYLEQMSSKESEPLTELYRKSVSHDWNKVHADGKTLFRLPVTCITGQVEGQVLKMLVHMSKAKRVLEIGMFTGYGALSMAEALPENGQLIACEL-EPYLKDFAQPIFDKSPHGKKITVKTGPAMDTLKELAATGEQ--FDMVFIDADKQNYINYYKFLLDHNLLRIDGVICVDNTLFKGRVYLKDSVDEMGKALRDFNQFVTADPRVEQVIIPLRDGLTI 267
[Close]
BLAST of O-methyltransferase vs. Ensembl Zebrafish
Match: comtd1 (catechol-O-methyltransferase domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-030131-1072])

HSP 1 Score: 54.6842 bits (130), Expect = 3.197e-9
Identity = 26/50 (52.00%), Postives = 37/50 (74.00%), Query Frame = 2 
Query:  560 VLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            VLWGG+V++    D  + AI KLN+KL  D+R D+SML +GDG+T+A K+
Sbjct:   70 VLWGGRVINPAEDDLSSQAIDKLNKKLHKDERIDLSMLTVGDGLTLAIKR 119
[Close]
BLAST of O-methyltransferase vs. Ensembl Zebrafish
Match: comta (catechol-O-methyltransferase a [Source:NCBI gene;Acc:561372])

HSP 1 Score: 46.595 bits (109), Expect = 9.191e-6
Identity = 39/143 (27.27%), Postives = 66/143 (46.15%), Query Frame = 2 
Query:  197 FLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWK---KGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMD---YYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDED 607
             L ++   +     L++G + GYS++ IA +L    K+    IT E+  D+   A +     G++DK+    GP+ + + K+       +FDF F+D  K  Y+      E C  L+R   ++  DNV+  G    L Y   D
Sbjct:   91 ILDSVVTEVNPSTALELGTYCGYSTVRIARLLSPGTKL----ITLEFNPDYAAIARQIIAYAGLQDKVILVEGPSGDLIPKMKQQHGIKSFDFVFLDHWKDRYVPDTKLLEEC-GLLRKGSVLLADNVICPGTPEYLKYVRND 228
[Close]
BLAST of O-methyltransferase vs. Ensembl Zebrafish
Match: comta (catechol-O-methyltransferase a [Source:NCBI gene;Acc:561372])

HSP 1 Score: 46.9802 bits (110), Expect = 9.270e-6
Identity = 39/143 (27.27%), Postives = 66/143 (46.15%), Query Frame = 2 
Query:  197 FLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWK---KGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMD---YYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDED 607
             L ++   +     L++G + GYS++ IA +L    K+    IT E+  D+   A +     G++DK+    GP+ + + K+       +FDF F+D  K  Y+      E C  L+R   ++  DNV+  G    L Y   D
Sbjct:  112 ILDSVVTEVNPSTALELGTYCGYSTVRIARLLSPGTKL----ITLEFNPDYAAIARQIIAYAGLQDKVILVEGPSGDLIPKMKQQHGIKSFDFVFLDHWKDRYVPDTKLLEEC-GLLRKGSVLLADNVICPGTPEYLKYVRND 249
[Close]
BLAST of O-methyltransferase vs. Ensembl Xenopus
Match: sccpdh.2 (saccharopine dehydrogenase (putative) [Source:Xenbase;Acc:XB-GENE-5761597])

HSP 1 Score: 48.1358 bits (113), Expect = 8.592e-6
Identity = 41/176 (23.30%), Postives = 83/176 (47.16%), Query Frame = 2 
Query:  194 QFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAF--DITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLK--LIRPNGLIAIDNVL-WGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            + L+++ R    K  L +G+ +   +L +A VLP++G+V     + + +  +D    A       +KI   +G   + L +L A G    FD  FIDA +  +++YY   +   +++ NG+I + + L      L++   +E +   RK+ + +  D   +   L +   + IA +
Sbjct:   78 KMLAHLTR---TKNILALGICSTSIALAMAHVLPKDGRVVLCLAEPSPQESQDHSPQA-------EKIQRKVGATCDILKELAASGEQ--FDMVFIDAAERSHINYYNLIMSGNMLKMNGVICVQSALVREHHSLEITGDEEGSAVARKVTDVINTDPALEQVTLPIDGSIIIARR 241
[Close]
BLAST of O-methyltransferase vs. Ensembl Mouse
Match: Comtd1 (catechol-O-methyltransferase domain containing 1 [Source:MGI Symbol;Acc:MGI:1916406])

HSP 1 Score: 161.384 bits (407), Expect = 2.910e-48
Identity = 83/211 (39.34%), Postives = 128/211 (60.66%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            + +  Y+   S++   + + L   T+E      + + E+ Q L+N+ R+I AKK LD+G FTGYS+L +A  LPE G+V   ++  E  K    P WK+  V  KI   L PA++ L++L+A G +GTFD A +DADK     YYE CL+L+RP G++A+  VLW G+VL    +++    +R LNE++  D R  IS+L + DG+++AFK
Sbjct:   52 NPLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIKAKKALDLGTFTGYSALALALALPEAGRVVTCEVDAEPPK-LGRPMWKQAEVEQKIDLRLQPALQTLDELLAAGEAGTFDIAVVDADKENCTAYYERCLQLLRPGGVLAVLRVLWRGEVLQPQPRNKTVECVRNLNERILRDARVYISLLPLDDGLSLAFK 261
[Close]
BLAST of O-methyltransferase vs. Ensembl Mouse
Match: Comtd1 (catechol-O-methyltransferase domain containing 1 [Source:MGI Symbol;Acc:MGI:1916406])

HSP 1 Score: 159.073 bits (401), Expect = 4.918e-48
Identity = 80/187 (42.78%), Postives = 118/187 (63.10%), Query Frame = 2 
Query:  146 TMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            T+E      + + E+ Q L+N+ R+I AKK LD+G FTGYS+L +A  LPE G+V   ++  E  K    P WK+  V  KI   L PA++ L++L+A G +GTFD A +DADK     YYE CL+L+RP G++A+  VLW G+VL    +++    +R LNE++  D R  IS+L + DG+++AFK
Sbjct:   14 TLEQPQGDSMMTCEQAQLLANLARLIKAKKALDLGTFTGYSALALALALPEAGRVVTCEVDAEPPK-LGRPMWKQAEVEQKIDLRLQPALQTLDELLAAGEAGTFDIAVVDADKENCTAYYERCLQLLRPGGVLAVLRVLWRGEVLQPQPRNKTVECVRNLNERILRDARVYISLLPLDDGLSLAFK 199
[Close]
BLAST of O-methyltransferase vs. UniProt/SwissProt
Match: sp|Q86IC8|CAMT2_DICDI (Probable caffeoyl-CoA O-methyltransferase 2 OS=Dictyostelium discoideum OX=44689 GN=omt6 PE=1 SV=1)

HSP 1 Score: 170.244 bits (430), Expect = 2.956e-51
Identity = 96/213 (45.07%), Postives = 132/213 (61.97%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTME-LNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDE-DTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            + I++Y  +HS + ++ QK LI+ T E +    ML   E+  F   + +++ AKKT+DIGVFTG SSLT A  + + G+V A D++ EY +   +  W K GV  KI+  + PA + L +LI  G   T+DF FIDADKTGY  YYE  LKLIR  G+IAIDNVL  G+V D N   E + VAIR LN+K+  D R   S+L + DG+T+  K
Sbjct:   18 NSILNYAIDHSDQLTDIQKELIQFTKENIERHIMLTQAEQCSFFKLLIQVLNAKKTIDIGVFTGLSSLTAALAMGDEGRVVACDVSTEYTQHALK-FWAKAGVDHKINLKIQPASKTLQELIDQGEENTYDFVFIDADKTGYDTYYELSLKLIRKGGIIAIDNVLQHGRVADPNANVEPNLVAIRALNDKILADKRVTKSLLPIADGITLITK 229
[Close]
BLAST of O-methyltransferase vs. UniProt/SwissProt
Match: sp|Q86IC9|CAMT1_DICDI (Probable caffeoyl-CoA O-methyltransferase 1 OS=Dictyostelium discoideum OX=44689 GN=omt5 PE=3 SV=1)

HSP 1 Score: 169.474 bits (428), Expect = 7.194e-51
Identity = 95/213 (44.60%), Postives = 132/213 (61.97%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTME-LNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDE-DTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            + I++Y  +HS + ++ QK LI+ T E +    ML   E+  F   + +++ AKKT+DIGVFTG SSLT A  + + G+V A D++ +Y +   +  W K GV  KI+  + PA + L +LI  G   T+DF FIDADKTGY  YYE  LKLIR  G+IAIDNVL  G+V D N   E + VAIR LN+K+  D R   +ML + DG+T+  K
Sbjct:   17 NSILNYAIDHSDQLTDIQKELIQFTKENIERHIMLTQAEQCSFFKLLIQVLNAKKTIDIGVFTGLSSLTAALAMGDEGRVVACDVSTDYTQHALK-FWAKAGVDHKINLKIQPASKTLQELIDQGEENTYDFVFIDADKTGYDTYYELSLKLIRKGGIIAIDNVLQHGRVADPNANVEPNLVAIRALNDKILADKRVTKTMLPIADGITLVTK 228
[Close]
BLAST of O-methyltransferase vs. UniProt/SwissProt
Match: sp|Q00719|MDMC_STRMY (O-methyltransferase MdmC OS=Streptomyces mycarofaciens OX=1949 GN=mdmC PE=3 SV=1)

HSP 1 Score: 163.696 bits (413), Expect = 9.886e-49
Identity = 84/211 (39.81%), Postives = 126/211 (59.72%), Query Frame = 2 
Query:   80 IVDYITEHSVKFSESQKWLIEKTMEL-NNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            ++DY    +++     + L + T +L     M    EE QFL  + R++GA++ L+IG FTGYS+L +A  LP  G++   DI+D++      P W++ GV   I   +G A   L +L      G FD  F+DADK GY+ YYE  L L+RP GL+AIDN L+ G+V D    D DTVA+R LN+ L+ D+R DI++L + DG+T+A ++
Sbjct:   11 LLDYARSVALREDGLLRELHDMTAQLPGGRAMQIMPEEAQFLGLLIRLVGARRVLEIGTFTGYSTLCMARALPAGGRIVTCDISDKW-PGIGAPFWQRAGVDGLIDLRIGDAARTLAELRERDGDGAFDLVFVDADKAGYLHYYEQALALVRPGGLVAIDNTLFFGRVADPAADDPDTVAVRTLNDLLRDDERVDIALLTVADGITLARRR 220
[Close]
BLAST of O-methyltransferase vs. UniProt/SwissProt
Match: sp|Q86VU5|CMTD1_HUMAN (Catechol O-methyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=COMTD1 PE=1 SV=1)

HSP 1 Score: 163.31 bits (412), Expect = 4.320e-48
Identity = 84/210 (40.00%), Postives = 127/210 (60.48%), Query Frame = 2 
Query:   77 KIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            ++  Y+   S++   + + L   T+E      + + E+ Q L+N+ R+I AKK LD+G FTGYS+L +A  LP +G+V   ++ D    +   P W++     KI   L PA+E L++L+A G +GTFD A +DADK     YYE CL+L+RP G++A+  VLW GKVL     D     +R LNE+++ D R  IS+L +GDG+T+AFK
Sbjct:   53 RLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALALALALPADGRVVTCEV-DAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFK 261
[Close]
BLAST of O-methyltransferase vs. UniProt/SwissProt
Match: sp|Q8BIG7|CMTD1_MOUSE (Catechol O-methyltransferase domain-containing protein 1 OS=Mus musculus OX=10090 GN=Comtd1 PE=1 SV=1)

HSP 1 Score: 161.384 bits (407), Expect = 2.036e-47
Identity = 83/211 (39.34%), Postives = 128/211 (60.66%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            + +  Y+   S++   + + L   T+E      + + E+ Q L+N+ R+I AKK LD+G FTGYS+L +A  LPE G+V   ++  E  K    P WK+  V  KI   L PA++ L++L+A G +GTFD A +DADK     YYE CL+L+RP G++A+  VLW G+VL    +++    +R LNE++  D R  IS+L + DG+++AFK
Sbjct:   52 NPLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIKAKKALDLGTFTGYSALALALALPEAGRVVTCEVDAEPPK-LGRPMWKQAEVEQKIDLRLQPALQTLDELLAAGEAGTFDIAVVDADKENCTAYYERCLQLLRPGGVLAVLRVLWRGEVLQPQPRNKTVECVRNLNERILRDARVYISLLPLDDGLSLAFK 261
[Close]
BLAST of O-methyltransferase vs. TrEMBL
Match: A0A5K4F6Z2 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 253.447 bits (646), Expect = 3.895e-81
Identity = 122/212 (57.55%), Postives = 153/212 (72.17%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            DK+  YI  HS++ SE+QKWL+++T +   S ML S  E+Q LSN+C  I A+KTLD+GV+TGYSSL+IA VLP +G+V A DITDEYLKD+C PAWK  GV  KI F  GPA+E L  LI +G S TFDFA IDADK  Y +YY+ CLKL+RP G+IAIDNVLW  +VLD N     TV IR++NE +  D+   +S+LR GDG+TI  KK
Sbjct:   39 DKLHQYICNHSIRLSETQKWLLQETSKHPMSLMLISSIEMQLLSNLCYGINARKTLDVGVYTGYSSLSIAEVLPPDGRVLALDITDEYLKDYCLPAWKMAGVESKIDFRHGPAVETLQNLIDNGESETFDFAMIDADKENYSNYYKLCLKLVRPRGIIAIDNVLWSHRVLDPNDNCPQTVGIREMNELIAGDNCVRVSLLRTGDGLTIVVKK 250
[Close]
BLAST of O-methyltransferase vs. TrEMBL
Match: C1L4K7 (Putative catechol-O-methyltransferase domain containing 1 OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 251.906 bits (642), Expect = 6.909e-81
Identity = 123/217 (56.68%), Postives = 153/217 (70.51%), Query Frame = 2 
Query:   59 YRKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            Y    D++  YIT+HS++ S++Q WLI++T +   S ML S  E+Q LSN+C +I AK TLDIGV+TGYS+L+IA VLP +G+V A DITD YL+D+C PAWK   V  KI F LGPA + L  LI +G+SGTFDFA IDADK  Y   YE CL+LIRP G+IAIDNVLW   VLD N K   TV+IRKLN+ L  D+R  IS L + DG+TI  KK
Sbjct:   11 YLPSSDEVYQYITDHSLRLSKAQNWLIQETSKHPLSAMLISDMEMQLLSNLCYMINAKMTLDIGVYTGYSALSIAEVLPSDGRVLALDITDAYLQDYCIPAWKMANVDSKIDFRLGPAAQTLQNLIDNGYSGTFDFALIDADKEEYSHLYELCLQLIRPRGIIAIDNVLWSLHVLDDNNKQPSTVSIRKLNDFLAKDERVRISFLNVSDGLTIVVKK 227
[Close]
BLAST of O-methyltransferase vs. TrEMBL
Match: A0A4Z2DNQ9 (Putative caffeoyl-CoA O-methyltransferase 2 isoform 1 OS=Schistosoma japonicum OX=6182 GN=EWB00_010596 PE=4 SV=1)

HSP 1 Score: 250.366 bits (638), Expect = 2.918e-80
Identity = 123/217 (56.68%), Postives = 153/217 (70.51%), Query Frame = 2 
Query:   59 YRKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            Y    D++  YIT+HS++ S++Q WLI++T +   S ML S  E+Q LSN+C +I AK TLDIGV+TGYS+L+IA VLP +G+V A DITD YL+D+C PAWK   V  KI F LGPA + L  LI +G+SGTFDFA IDADK  Y   YE CL+LIRP G+IAIDNVLW   VLD N K   TV+IRKLN+ L  D+R  IS L + DG+TI  KK
Sbjct:   11 YLPSSDEVYQYITDHSLRLSKAQNWLIQETSKHPLSAMLISDMEMQLLSNLCYMINAKMTLDIGVYTGYSALSIAEVLPSDGRVLALDITDAYLQDYCIPAWKMANVDSKIDFRLGPAAQTLQNLIDNGYSGTFDFALIDADKEEYSHLYELCLQLIRPRGIIAIDNVLWLLHVLDDNNKQPSTVSIRKLNDFLAKDERVRISFLNVSDGLTIVVKK 227
[Close]
BLAST of O-methyltransferase vs. TrEMBL
Match: A0A5K4F4E6 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 250.366 bits (638), Expect = 4.187e-80
Identity = 121/212 (57.08%), Postives = 153/212 (72.17%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            DK+  YI  HS++ S++QKWL+++T +   S ML S  E+Q LSN+C  I A+KTLD+GV+TGYSSL+IA VLP +G+V A DITDEYLKD+C PAWK  GV  KI F  GPA+E L  LI +G S TFDFA IDADK  Y +YY+ CLKL+RP G+IAIDNVLW  +VLD N     TV IR++NE +  D+   +S+LR GDG+TI  KK
Sbjct:   20 DKLHQYICNHSLRLSKAQKWLLQETSKHPMSLMLISSIEMQLLSNLCYGINARKTLDVGVYTGYSSLSIAEVLPPDGRVLALDITDEYLKDYCLPAWKMAGVESKIDFRHGPAVETLQNLIDNGESETFDFAMIDADKENYSNYYKLCLKLVRPRGIIAIDNVLWSHRVLDPNDNCPQTVGIREMNELIAGDNCVRVSLLRTGDGLTIVVKK 231
[Close]
BLAST of O-methyltransferase vs. TrEMBL
Match: A0A4Z2DNT7 (Putative caffeoyl-CoA O-methyltransferase 2 isoform 2 (Fragment) OS=Schistosoma japonicum OX=6182 GN=EWB00_010596 PE=4 SV=1)

HSP 1 Score: 250.366 bits (638), Expect = 8.696e-80
Identity = 123/217 (56.68%), Postives = 153/217 (70.51%), Query Frame = 2 
Query:   59 YRKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            Y    D++  YIT+HS++ S++Q WLI++T +   S ML S  E+Q LSN+C +I AK TLDIGV+TGYS+L+IA VLP +G+V A DITD YL+D+C PAWK   V  KI F LGPA + L  LI +G+SGTFDFA IDADK  Y   YE CL+LIRP G+IAIDNVLW   VLD N K   TV+IRKLN+ L  D+R  IS L + DG+TI  KK
Sbjct:   45 YLPSSDEVYQYITDHSLRLSKAQNWLIQETSKHPLSAMLISDMEMQLLSNLCYMINAKMTLDIGVYTGYSALSIAEVLPSDGRVLALDITDAYLQDYCIPAWKMANVDSKIDFRLGPAAQTLQNLIDNGYSGTFDFALIDADKEEYSHLYELCLQLIRPRGIIAIDNVLWLLHVLDDNNKQPSTVSIRKLNDFLAKDERVRISFLNVSDGLTIVVKK 261
[Close]
BLAST of O-methyltransferase vs. Ensembl Cavefish
Match: COMTD1 (catechol O-methyltransferase domain-containing protein 1-like [Source:NCBI gene;Acc:103041538])

HSP 1 Score: 199.519 bits (506), Expect = 1.155e-63
Identity = 102/211 (48.34%), Postives = 145/211 (68.72%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            + ++ YI EHS++   + K L  KTME   + ++ + E+ Q ++N+ R+I +KK ++IGV+TGY++L+IA  LPE+GKV A D+ +E+  +   P WK+ GV  KI   L PA++ L++L+A G + TFDF FIDADK  Y  YYE  LKL+R  G+IAIDNVLW G+VL+    D DT AI KLN+KL  D R  +SML +GDG+T+AFK
Sbjct:   13 NPVMQYILEHSMREHPALKKLRLKTMEHKLNFIMVACEQSQLMANLARLIKSKKAIEIGVYTGYNALSIALALPEDGKVVACDVNEEF-TNIGRPFWKEAGVEHKIDLRLQPALKTLDELLAAGEAETFDFVFIDADKLNYDSYYEKSLKLLRKGGIIAIDNVLWSGRVLNPAEDDLDTKAIDKLNKKLHKDVRITLSMLTVGDGLTLAFK 222
[Close]
BLAST of O-methyltransferase vs. Ensembl Cavefish
Match: COMTD1 (catechol O-methyltransferase domain-containing protein 1-like [Source:NCBI gene;Acc:103041538])

HSP 1 Score: 199.519 bits (506), Expect = 3.370e-63
Identity = 102/211 (48.34%), Postives = 145/211 (68.72%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            + ++ YI EHS++   + K L  KTME   + ++ + E+ Q ++N+ R+I +KK ++IGV+TGY++L+IA  LPE+GKV A D+ +E+  +   P WK+ GV  KI   L PA++ L++L+A G + TFDF FIDADK  Y  YYE  LKL+R  G+IAIDNVLW G+VL+    D DT AI KLN+KL  D R  +SML +GDG+T+AFK
Sbjct:   47 NPVMQYILEHSMREHPALKKLRLKTMEHKLNFIMVACEQSQLMANLARLIKSKKAIEIGVYTGYNALSIALALPEDGKVVACDVNEEF-TNIGRPFWKEAGVEHKIDLRLQPALKTLDELLAAGEAETFDFVFIDADKLNYDSYYEKSLKLLRKGGIIAIDNVLWSGRVLNPAEDDLDTKAIDKLNKKLHKDVRITLSMLTVGDGLTLAFK 256
[Close]
BLAST of O-methyltransferase vs. Ensembl Cavefish
Match: comtd1 (catechol O-methyltransferase domain-containing protein 1 [Source:NCBI gene;Acc:103038538])

HSP 1 Score: 177.178 bits (448), Expect = 5.565e-55
Identity = 84/215 (39.07%), Postives = 144/215 (66.98%), Query Frame = 2 
Query:   62 RKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
             KG + ++ Y+  +S++       L  +TME    GM+ + E+ Q ++N+ ++I   KT++IG++TGY++L++A  +PE+GKV A +I ++Y+ +  +P + + GV +K++    PA+  L++L+  G +GT+DF FIDADK    +YYE  L+L+R  G++AIDNVLWGG+V++    D  + +I +LN+K+  D R D+SML +GDG+T+A K
Sbjct:   11 HKGDNPLLQYVLNNSLREHPVLTKLRLRTMEDPRKGMMVAAEQAQLMANLLKLIKGNKTIEIGMYTGYNTLSMALSVPEDGKVVACEIEEKYI-NISKPFFAEAGVENKVNIRQQPALTTLDELLQAGEAGTYDFVFIDADKKNNENYYEKSLQLLRKGGIVAIDNVLWGGRVINPEESDTTSQSIDELNKKIHKDKRVDLSMLPVGDGLTLAIK 224
[Close]
BLAST of O-methyltransferase vs. Ensembl Cavefish
Match: comtd1 (catechol O-methyltransferase domain-containing protein 1 [Source:NCBI gene;Acc:103038538])

HSP 1 Score: 176.792 bits (447), Expect = 1.610e-54
Identity = 84/215 (39.07%), Postives = 144/215 (66.98%), Query Frame = 2 
Query:   62 RKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
             KG + ++ Y+  +S++       L  +TME    GM+ + E+ Q ++N+ ++I   KT++IG++TGY++L++A  +PE+GKV A +I ++Y+ +  +P + + GV +K++    PA+  L++L+  G +GT+DF FIDADK    +YYE  L+L+R  G++AIDNVLWGG+V++    D  + +I +LN+K+  D R D+SML +GDG+T+A K
Sbjct:   34 HKGDNPLLQYVLNNSLREHPVLTKLRLRTMEDPRKGMMVAAEQAQLMANLLKLIKGNKTIEIGMYTGYNTLSMALSVPEDGKVVACEIEEKYI-NISKPFFAEAGVENKVNIRQQPALTTLDELLQAGEAGTYDFVFIDADKKNNENYYEKSLQLLRKGGIVAIDNVLWGGRVINPEESDTTSQSIDELNKKIHKDKRVDLSMLPVGDGLTLAIK 247
[Close]
BLAST of O-methyltransferase vs. Ensembl Cavefish
Match: zgc:113054 (uncharacterized LOC103021811 [Source:NCBI gene;Acc:103021811])

HSP 1 Score: 120.168 bits (300), Expect = 1.236e-30
Identity = 63/172 (36.63%), Postives = 104/172 (60.47%), Query Frame = 2 
Query:  188 ELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLK--LIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTI 697
            E QFL  +  +  A+K L+IG+FTGY +L++A  LPE+G++ A +I + YL+DF +P +       KI+  +G A+E L +    G    FD  FIDADK  Y+ YY   L+  L+R +G++ +DN L+ GKV   +  D++ +++R+ N+ +  D R    M+ + DG+T+
Sbjct:   99 EGQFLKMLVHMSKARKVLEIGMFTGYGALSMAEALPEDGRLIACEI-EPYLRDFVQPVFDSSPHGKKITVKVGSAMESLKEFAGAGEQ--FDLVFIDADKNNYLSYYTFLLEHNLLRMDGVLCVDNALFKGKVYLSDSTDQNGLSLREFNQLVASDPRVQQVMIPLRDGITL 267
[Close]
BLAST of O-methyltransferase vs. Ensembl Sea Lamprey
Match: comtd1 (catechol-O-methyltransferase domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-030131-1072])

HSP 1 Score: 211.075 bits (536), Expect = 7.031e-69
Identity = 103/213 (48.36%), Postives = 153/213 (71.83%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEK-TMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            + +++YI   S++   + + L  K TM+   SGM+ + E+ Q ++N+ R+IG KK +++GV+TGY++L+IA  LP++GK+ A DIT+E+  +  +P WK+ GV  KI   + PA   L+ L+A G  GT+DFAFIDADK GY+ YYE CL+LIR  G++AIDNV+WGG VL+    DE+T++I +LN+KLK D R DISML +GDG+T+AFK+
Sbjct:   21 NSMMEYIISRSLREHPALEKLRNKCTMQHPASGMMVACEQSQLMANLLRLIGGKKAIEVGVYTGYNTLSIALALPDDGKIVACDITEEF-PNIGKPYWKEAGVEHKIDLRIKPASATLDDLLAAGEEGTYDFAFIDADKEGYVSYYEKCLRLIRKGGIVAIDNVIWGGSVLNPRKDDEETMSICRLNDKLKDDQRVDISMLTIGDGLTLAFKR 232
[Close]
BLAST of O-methyltransferase vs. Ensembl Nematostella
Match: EDO43225 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZ56])

HSP 1 Score: 142.895 bits (359), Expect = 7.895e-43
Identity = 79/157 (50.32%), Postives = 104/157 (66.24%), Query Frame = 2 
Query:  245 IGVFTGYSSLTIASVLPENGKVYAFDITDEYLK--DFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVL-DLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            +GVFTGY+++ +A  LP  GKV A D+TDE LK  DF     K+ GV DK+   + PAI+ L++LI +G SGT+DF FIDADK   M YYE  L L+R  G++AIDNV++GGKV  D    DE T  I +LN K+  D+R  ++ML   DGVT+A K
Sbjct:    1 LGVFTGYNTINMAMCLPYGGKVVACDVTDESLKAVDFTS-LVKEAGVEDKVDLRIQPAIKTLDELIVNGESGTYDFVFIDADKPSQMIYYEKSLVLLRQGGMVAIDNVIFGGKVTKDPLEMDEGTKCIHELNMKIHKDERVTMAMLPFADGVTLATK 156
[Close]
BLAST of O-methyltransferase vs. Ensembl Nematostella
Match: EDO40475 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S758])

HSP 1 Score: 81.2629 bits (199), Expect = 5.146e-19
Identity = 51/172 (29.65%), Postives = 84/172 (48.84%), Query Frame = 2 
Query:  188 ELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDT--VAIRKLNEKLKVDDRCDISMLRMGDGVTI 697
            E QFL  + +I  AK+ LD+G FTG S++  A  +P +G+V   +  D+ +    +  ++      K++  +G A++ +  L        FD  F+DA K  Y+ YY   L ++ P G I  DN L       L Y  +D+   A+   N+ +K D R +   L   +GV+I
Sbjct:    6 ESQFLKMMAQIANAKRVLDVGTFTGMSAMAFAEGIPPDGQVVTIEF-DQTIASTADKLFRDSAQAHKLALKVGDAVDVMTDL--KSAQEKFDIIFLDAAKDQYITYYHLALSMLTPTGFILADNSLCA-----LLYDPDDSRRQALHDFNQLVKNDKRVEQLALPFREGVSI 169
[Close]
BLAST of O-methyltransferase vs. Ensembl Medaka
Match: COMTD1 (catechol-O-methyltransferase domain containing 1 [Source:NCBI gene;Acc:101171203])

HSP 1 Score: 202.986 bits (515), Expect = 7.287e-65
Identity = 100/211 (47.39%), Postives = 148/211 (70.14%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            D ++ Y+  HS++     K L  +TME   + M+ + E+ QF++N+ ++I AKK ++IGV+TGY++L++A  LPE+G V A DI++E+  +  +P WK+ GV  KI   + PA++ L+ L++ G + TFDF FIDADKT Y +YYE  L+L+R  G+IAIDNVLWGG+VL+ +  D DTVAI KLN+KL  D R  +SML +GDG+T+A K
Sbjct:   27 DPLMQYVLNHSLREHPVLKKLRLRTMEDPRNIMMVACEQSQFMANLAKLIQAKKAIEIGVYTGYNTLSVALALPEDGVVVACDISEEF-TNIAKPFWKEAGVEKKIDLRIQPAVKTLDDLLSSGQAETFDFVFIDADKTNYDNYYEKSLQLLRKGGIIAIDNVLWGGQVLNPSPGDADTVAIDKLNKKLHRDFRVTLSMLTVGDGLTLAVK 236
[Close]
BLAST of O-methyltransferase vs. Ensembl Medaka
Match: COMTD1 (catechol-O-methyltransferase domain containing 1 [Source:NCBI gene;Acc:101171203])

HSP 1 Score: 202.216 bits (513), Expect = 2.588e-64
Identity = 100/211 (47.39%), Postives = 148/211 (70.14%), Query Frame = 2 
Query:   74 DKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFK 706
            D ++ Y+  HS++     K L  +TME   + M+ + E+ QF++N+ ++I AKK ++IGV+TGY++L++A  LPE+G V A DI++E+  +  +P WK+ GV  KI   + PA++ L+ L++ G + TFDF FIDADKT Y +YYE  L+L+R  G+IAIDNVLWGG+VL+ +  D DTVAI KLN+KL  D R  +SML +GDG+T+A K
Sbjct:   47 DPLMQYVLNHSLREHPVLKKLRLRTMEDPRNIMMVACEQSQFMANLAKLIQAKKAIEIGVYTGYNTLSVALALPEDGVVVACDISEEF-TNIAKPFWKEAGVEKKIDLRIQPAVKTLDDLLSSGQAETFDFVFIDADKTNYDNYYEKSLQLLRKGGIIAIDNVLWGGQVLNPSPGDADTVAIDKLNKKLHRDFRVTLSMLTVGDGLTLAVK 256
[Close]
BLAST of O-methyltransferase vs. Ensembl Medaka
Match: zgc:113054 (uncharacterized LOC101163242 [Source:NCBI gene;Acc:101163242])

HSP 1 Score: 107.842 bits (268), Expect = 2.923e-26
Identity = 68/219 (31.05%), Postives = 121/219 (55.25%), Query Frame = 2 
Query:   89 YITEHSVKFSESQKWLIEKTMELNNSGMLGSGE--------------ELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLK--LIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTI 697
            Y+ + + + SE  + L EKTM  + + +   G+              E Q L  +  +  AK+ L+IG+FTGY +L++A  LP++G + A ++ + YLK+F +P + K     KI    GPA++ L +L   G    FD  FIDADK  Y++YY   ++  +++  G++ +DN L+ GKV   N  D + +A+R+ N+ +  D R +  ++ + DG+++
Sbjct:   52 YLEKMTTQESEPLRELYEKTMSHDWNQVHKEGKTIFQLPKECITGHVEGQTLKMLIHMSQAKRVLEIGMFTGYGALSMAEGLPDDGLLIACEL-EPYLKEFAQPIFDKSPHGKKIIVKSGPAMDTLKELALAGEQ--FDMVFIDADKNNYINYYNFIMENNMLKLRGVMCVDNSLFKGKVYLENATDSNGLALREFNQFVSNDPRVEQVIIPLRDGISL 267
[Close]
BLAST of O-methyltransferase vs. Ensembl Medaka
Match: zgc:113054 (uncharacterized LOC101163242 [Source:NCBI gene;Acc:101163242])

HSP 1 Score: 101.293 bits (251), Expect = 4.885e-24
Identity = 60/172 (34.88%), Postives = 104/172 (60.47%), Query Frame = 2 
Query:  179 SGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLK--LIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCD----ISMLR 676
            +G+ L+ L ++ +   AK+ L+IG+FTGY +L++A  LP++G + A ++ + YLK+F +P + K     KI    GPA++ L +L   G    FD  FIDADK  Y++YY   ++  +++  G++ +DN L+ GKV   N  D + +A+R+ N+ +  D R +    IS++R
Sbjct:   69 AGQTLKMLIHMSQ---AKRVLEIGMFTGYGALSMAEGLPDDGLLIACEL-EPYLKEFAQPIFDKSPHGKKIIVKSGPAMDTLKELALAGEQ--FDMVFIDADKNNYINYYNFIMENNMLKLRGVMCVDNSLFKGKVYLENATDSNGLALREFNQFVSNDPRVEQVDGISLIR 234
[Close]
BLAST of O-methyltransferase vs. Ensembl Medaka
Match: comtb (catechol-O-methyltransferase [Source:NCBI gene;Acc:101166546])

HSP 1 Score: 48.1358 bits (113), Expect = 2.602e-6
Identity = 39/124 (31.45%), Postives = 60/124 (48.39%), Query Frame = 2 
Query:  236 TLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEP-AWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMD---YYEACLKLIRPNGLIAIDNVLWGGKVLDLNY 595
             L++G + GYS++ IAS+L  N K+   +   EY K   +  AW   G++DKI    G + + + K+       TFD  F+D  K  Y+      E C  L+R   ++  DNV+  G    L Y
Sbjct:  112 VLELGTYCGYSTVRIASLLSPNSKLITVEFNPEYAKIARQVIAW--AGLQDKIHLVEGASGDLIPKMQEMFGVKTFDLVFLDHWKDRYLPDTKLMEKC-GLLRKGSILLADNVICPGTPDYLEY 232
[Close]
BLAST of O-methyltransferase vs. Planmine SMEST
Match: SMESG000063332.1 (SMESG000063332.1)

HSP 1 Score: 449.899 bits (1156), Expect = 1.386e-162
Identity = 221/222 (99.55%), Postives = 221/222 (99.55%), Query Frame = 2 
Query:   44 MTTKTYRKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 709
            MTTKTYRKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIR NGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK
Sbjct:    1 MTTKTYRKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEELQFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLKDFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTGYMDYYEACLKLIRSNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLKVDDRCDISMLRMGDGVTIAFKK 222
The following BLAST results are available for this feature:
BLAST of O-methyltransferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
COMTD18.996e-4940.00catechol-O-methyltransferase domain containing 1 [... [more]
COMTD14.515e-4843.39catechol-O-methyltransferase domain containing 1 [... [more]
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BLAST of O-methyltransferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
comt-46.892e-5743.17Catechol-O-MethylTransferase family [Source:UniPr... [more]
comt-52.197e-5642.92Catechol-O-MethylTransferase family [Source:UniPr... [more]
comt-35.358e-5042.11Catechol-O-MethylTransferase family [Source:UniPr... [more]
comt-23.020e-4745.02Catechol-O-MethylTransferase family [Source:UniPr... [more]
comt-31.420e-4544.74Catechol-O-MethylTransferase family [Source:UniPr... [more]
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BLAST of O-methyltransferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of O-methyltransferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
comtd12.489e-5942.59catechol-O-methyltransferase domain containing 1 [... [more]
zgc:1130541.835e-3134.96zgc:113054 [Source:ZFIN;Acc:ZDB-GENE-050320-9][more]
comtd13.197e-952.00catechol-O-methyltransferase domain containing 1 [... [more]
comta9.191e-627.27catechol-O-methyltransferase a [Source:NCBI gene;A... [more]
comta9.270e-627.27catechol-O-methyltransferase a [Source:NCBI gene;A... [more]
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BLAST of O-methyltransferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
sccpdh.28.592e-623.30saccharopine dehydrogenase (putative) [Source:Xenb... [more]
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BLAST of O-methyltransferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Comtd12.910e-4839.34catechol-O-methyltransferase domain containing 1 [... [more]
Comtd14.918e-4842.78catechol-O-methyltransferase domain containing 1 [... [more]
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BLAST of O-methyltransferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q86IC8|CAMT2_DICDI2.956e-5145.07Probable caffeoyl-CoA O-methyltransferase 2 OS=Dic... [more]
sp|Q86IC9|CAMT1_DICDI7.194e-5144.60Probable caffeoyl-CoA O-methyltransferase 1 OS=Dic... [more]
sp|Q00719|MDMC_STRMY9.886e-4939.81O-methyltransferase MdmC OS=Streptomyces mycarofac... [more]
sp|Q86VU5|CMTD1_HUMAN4.320e-4840.00Catechol O-methyltransferase domain-containing pro... [more]
sp|Q8BIG7|CMTD1_MOUSE2.036e-4739.34Catechol O-methyltransferase domain-containing pro... [more]
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BLAST of O-methyltransferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K4F6Z23.895e-8157.55Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
C1L4K76.909e-8156.68Putative catechol-O-methyltransferase domain conta... [more]
A0A4Z2DNQ92.918e-8056.68Putative caffeoyl-CoA O-methyltransferase 2 isofor... [more]
A0A5K4F4E64.187e-8057.08Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A4Z2DNT78.696e-8056.68Putative caffeoyl-CoA O-methyltransferase 2 isofor... [more]
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BLAST of O-methyltransferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
COMTD11.155e-6348.34catechol O-methyltransferase domain-containing pro... [more]
COMTD13.370e-6348.34catechol O-methyltransferase domain-containing pro... [more]
comtd15.565e-5539.07catechol O-methyltransferase domain-containing pro... [more]
comtd11.610e-5439.07catechol O-methyltransferase domain-containing pro... [more]
zgc:1130541.236e-3036.63uncharacterized LOC103021811 [Source:NCBI gene;Acc... [more]
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BLAST of O-methyltransferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
comtd17.031e-6948.36catechol-O-methyltransferase domain containing 1 [... [more]
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BLAST of O-methyltransferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of O-methyltransferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO432257.895e-4350.32Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO404755.146e-1929.65Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of O-methyltransferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
COMTD17.287e-6547.39catechol-O-methyltransferase domain containing 1 [... [more]
COMTD12.588e-6447.39catechol-O-methyltransferase domain containing 1 [... [more]
zgc:1130542.923e-2631.05uncharacterized LOC101163242 [Source:NCBI gene;Acc... [more]
zgc:1130544.885e-2434.88uncharacterized LOC101163242 [Source:NCBI gene;Acc... [more]
comtb2.602e-631.45catechol-O-methyltransferase [Source:NCBI gene;Acc... [more]
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BLAST of O-methyltransferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000063332.11.386e-16299.55SMESG000063332.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30016967 ID=SMED30016967|Name=O-methyltransferase|organism=Schmidtea mediterranea sexual|type=transcript|length=783bp
TTGAAATTTTAAAATTGTAGTATTAGAATTTTTTTATTTAATAATGACTA
CCAAAACATATAGAAAAGGATTGGATAAAATTGTTGACTATATTACTGAG
CATTCTGTAAAATTTTCTGAATCACAAAAATGGTTAATTGAAAAAACAAT
GGAATTAAATAATAGTGGGATGCTTGGATCAGGTGAAGAGCTACAATTTT
TGTCAAATATTTGCAGAATAATCGGAGCGAAGAAAACATTAGATATTGGC
GTTTTCACTGGTTATAGTTCATTAACTATTGCTTCGGTTCTTCCAGAAAA
TGGGAAAGTTTATGCTTTCGATATAACAGATGAATATTTAAAAGACTTTT
GTGAACCTGCTTGGAAAAAAGGAGGAGTACGAGATAAAATATCCTTTAAC
TTAGGGCCTGCTATTGAAGGATTAAATAAACTCATTGCTGATGGACATTC
AGGAACGTTTGATTTTGCGTTTATCGATGCCGATAAAACTGGTTACATGG
ATTATTATGAGGCTTGCTTGAAATTGATACGGCCAAATGGGTTAATTGCT
ATTGATAATGTTCTATGGGGTGGGAAAGTTTTAGATTTAAATTACAAGGA
TGAAGATACGGTAGCTATTAGAAAATTGAATGAAAAGTTAAAAGTGGATG
ATAGATGTGATATTTCGATGCTAAGAATGGGGGATGGAGTTACTATAGCT
TTTAAAAAATGAGAATTTCATCATTTTTATATTCTGATTTGTCTTCAAGA
TATAAATAAATAGTTTGTTGATTTCAAAAAAAA
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protein sequence of SMED30016967-orf-1

>SMED30016967-orf-1 ID=SMED30016967-orf-1|Name=SMED30016967-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=223bp
MTTKTYRKGLDKIVDYITEHSVKFSESQKWLIEKTMELNNSGMLGSGEEL
QFLSNICRIIGAKKTLDIGVFTGYSSLTIASVLPENGKVYAFDITDEYLK
DFCEPAWKKGGVRDKISFNLGPAIEGLNKLIADGHSGTFDFAFIDADKTG
YMDYYEACLKLIRPNGLIAIDNVLWGGKVLDLNYKDEDTVAIRKLNEKLK
VDDRCDISMLRMGDGVTIAFKK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000070intestinal phagocyte
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR002935SAM_O-MeTrfase
IPR029063SAM-dependent_MTases
Vocabulary: molecular function
TermDefinition
GO:0008171O-methyltransferase activity
GO:0008168methyltransferase activity
GO:0016206catechol O-methyltransferase activity
GO:0016740transferase activity
GO:0102084L-dopa O-methyltransferase activity
Vocabulary: biological process
TermDefinition
GO:0032259methylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002935Class I-like SAM-dependent O-methyltransferasePFAMPF01596Methyltransf_3coord: 21..221
e-value: 1.1E-57
score: 194.6
IPR002935Class I-like SAM-dependent O-methyltransferasePROSITEPS51682SAM_OMT_Icoord: 4..222
score: 52.366
NoneNo IPR availableGENE3DG3DSA:3.40.50.150coord: 5..222
e-value: 4.9E-63
score: 214.5
NoneNo IPR availablePANTHERPTHR10509:SF14CATECHOL O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1coord: 11..221
NoneNo IPR availablePANTHERPTHR10509O-METHYLTRANSFERASE-RELATEDcoord: 11..221
NoneNo IPR availableCDDcd02440AdoMet_MTasescoord: 66..170
e-value: 0.00129238
score: 35.0983
IPR029063S-adenosyl-L-methionine-dependent methyltransferaseSUPERFAMILYSSF53335S-adenosyl-L-methionine-dependent methyltransferasescoord: 12..222