TNF receptor associated factor-2

Overview
NameTNF receptor associated factor-2 (AFJ24792.1)
Smed IDSMED30016919
Length (bp)1418
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TNF receptor associated factor-2 (SMED30016919) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TNF receptor associated factor-2 (SMED30016919) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30016919

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30016919h1SMcG0005645 dd_Smed_v4_10569_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30016919h1SMcG0005645 dd_Smed_v4_10569_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30016919h1SMcG0005645 dd_Smed_v4_10569_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30016919h1SMcG0005645 dd_Smed_v4_10569_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30016919h1SMcG0005645 dd_Smed_v4_10569_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Match: TRAF2 (TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032])

HSP 1 Score: 62.3882 bits (150), Expect = 7.863e-10
Identity = 87/416 (20.91%), Postives = 152/416 (36.54%), Query Frame = 3 
Query:  159 CDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSE-CKEENLTI--CSNIHTDYRVNRKIAKMRVKCPEE---------------------------TCKVYCELVDIEEHL-----------RLCT-------MKSQN--CPFFVL---GCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEG-SKLRRDFQEFQERIELKVQNIE----------SYLKQKIDET-----SGIFSWNVNGISAKRKEN-----QSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNR 1184
            C  C+N+L    Q++CG R+CS C+   +S G   C     E   EE ++I   S+   D    R++  +   CP +                            CK    L + E HL           R C        +K+ +  CP F L   GC + K+  +   +H++             I  +          E +   ++  ++ H       M+L +         +          + E  +K     E I     +  +  A  +TAE  S+  R  Q+  E +  KVQ +E          + L+QK+ E       G+F W ++  + KR+E       ++FS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ ++++
Sbjct:   34 CSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLET-----VEGEKQQEHEVQWLREHL-----AMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVA--MTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQ 437
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 55.4546 bits (132), Expect = 1.311e-7
Identity = 92/447 (20.58%), Postives = 179/447 (40.04%), Query Frame = 3 
Query:  141 VPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEET--CKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQP----KMVIQDLTNHLQNG------TFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHF-------QSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVE---------DKMVDLVEKI--KLAETKTKQECAEIVTAEGSKLRRDFQEFQERIELK-VQNIESYLKQKIDETS---GIFSWNVNGISAKRKE-----NQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVN-----RSVPDSSKIVTKCFRIEEPPCNYNWSD--PFYFCYDELSGAGLLLNDSFTIECFVD 1343
            V D  KC+ C  +L +  Q+ CG RFC  C+   +S  +  C    + C+E    +   +  D    R+I  +++ C  E+  C     L  +  HL+       +C F  L C +P    K++ +DL +H++        T  H K  + +I+        L  + VE  + I  + N         + Q E++    S+I  +++       + K L  E+          D M   VE +  ++ E ++  + A  V      L        + + +  ++  +  L+ ++ ET+   G+  W +     +++E       S++S+ FYT    +K+  +   N          ++F  I  G  ++ L WPF+  VT+ +++     R + D+ K        ++P    N +   P +     L     + +D+  I+  VD
Sbjct:   47 VEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKC----TACQES--IVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLK------NDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQ---VSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVD 478
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Match: TRAF6 (TNF receptor associated factor 6 [Source:HGNC Symbol;Acc:HGNC:12036])

HSP 1 Score: 54.6842 bits (130), Expect = 2.289e-7
Identity = 32/114 (28.07%), Postives = 50/114 (43.86%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCP 458
            Y+ E +  +    +C +C   L  A Q+ CG RFC  CI+  +      CP       +  + + + +  D    R+I  + VKCP E C    EL  +E+H   C     +CP
Sbjct:   56 YDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCP------VDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Match: TRAF6 (TNF receptor associated factor 6 [Source:HGNC Symbol;Acc:HGNC:12036])

HSP 1 Score: 54.6842 bits (130), Expect = 2.289e-7
Identity = 32/114 (28.07%), Postives = 50/114 (43.86%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCP 458
            Y+ E +  +    +C +C   L  A Q+ CG RFC  CI+  +      CP       +  + + + +  D    R+I  + VKCP E C    EL  +E+H   C     +CP
Sbjct:   56 YDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCP------VDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Fly
Match: Traf6 (gene:FBgn0265464 transcript:FBtr0071188)

HSP 1 Score: 53.1434 bits (126), Expect = 3.597e-7
Identity = 35/144 (24.31%), Postives = 62/144 (43.06%), Query Frame = 3 
Query:  156 KCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEET--CKVYCELVDIEEHLRLCTMKSQN------CPFFVLGCN---QPKMVIQDLTNHLQNGTFQHSKLII 554
            +C +C + L     + CG RFC  C+  ++ + N  CP        E+     +I  D    R+I +++  CP  +  C V    +++  HL  C  + Q       CPF  + C+   +P+     L  HL+     H +L++
Sbjct:  103 ECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMDNKRLSAEH-----DIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPYRRQQEPQEEKCPFAKIKCDFVGRPE--TNQLEEHLKADMPHHMQLML 239
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: traf3 (TNF receptor-associated factor 3 [Source:ZFIN;Acc:ZDB-GENE-040801-257])

HSP 1 Score: 56.9954 bits (136), Expect = 3.287e-8
Identity = 41/122 (33.61%), Postives = 58/122 (47.54%), Query Frame = 3 
Query:  159 CDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEET--CKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHL 518
            C+ C+ +L N  Q+ CG RFC  CI + +S+ N  CP       E+       I  D   NR+I  ++V C  E   CK    L  + EHL +C      CP   LG  + KM+ +D+  HL
Sbjct:   56 CETCRLVLCNPRQTECGHRFCESCINELLSKPNPVCPADLLPLFED------KIFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVMEHLVICPYFEVPCP---LGKCKEKMMRKDMPEHL 168
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: unm_sa808 (un-named sa808 [Source:ZFIN;Acc:ZDB-GENE-120727-21])

HSP 1 Score: 53.9138 bits (128), Expect = 1.225e-7
Identity = 28/107 (26.17%), Postives = 53/107 (49.53%), Query Frame = 3 
Query:  885 ELKVQNIESYLKQKIDET-SGIFSWNVNGISAKRKEN-----QSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRS 1187
            +L V  +E  L++    T  G+F W ++  + KR++       +MFS  FYT    +K+ L+   N          ++F  +  G+ ++ L WPF   VT+ ++++S
Sbjct:  112 DLTVAEMEGRLREMSATTFDGVFIWRISDFTKKRQDAIAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGMSDALLKWPFNQKVTLMLLDQS 218
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: traf2a (Tnf receptor-associated factor 2a [Source:ZFIN;Acc:ZDB-GENE-071120-2])

HSP 1 Score: 51.6026 bits (122), Expect = 1.718e-6
Identity = 26/106 (24.53%), Postives = 52/106 (49.06%), Query Frame = 3 
Query:  885 ELKVQNIESYLKQKIDET-SGIFSWNVNGISAKRKEN-----QSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNR 1184
            +L +  +E+ +++    T  G+F W ++  S KR++       +MFS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ ++++
Sbjct:  406 DLSIVEMEAKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 511
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 50.8322 bits (120), Expect = 3.014e-6
Identity = 34/114 (29.82%), Postives = 47/114 (41.23%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCP 458
            Y+ E +  +    +C +C   L +A Q+ CG RFC  CI   +      CP       EE L        D    R+I  + VKC    C    EL  +E+HL  C   +  CP
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQL------FPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCP 164
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 50.8322 bits (120), Expect = 3.014e-6
Identity = 34/114 (29.82%), Postives = 47/114 (41.23%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCP 458
            Y+ E +  +    +C +C   L +A Q+ CG RFC  CI   +      CP       EE L        D    R+I  + VKC    C    EL  +E+HL  C   +  CP
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQL------FPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCP 164
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 66.2402 bits (160), Expect = 4.295e-11
Identity = 83/380 (21.84%), Postives = 144/380 (37.89%), Query Frame = 3 
Query:  159 CDLCKNLLVNACQSRCGCRFCSKC---IMDYVSR---GNLYCP---------GGTSECKEEN-----LTICSNIHTDYRVNRKIAKMRVKCPEET-----CKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVEDK-------MVDLVEKIKLAETKTKQECAEIVTAEGSKLRRDFQEFQERIELKVQNIESYLKQ-KIDETSGIFSWNVNGISAKRKEN-----QSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNR 1184
            C  CKNLL    Q++CG R+CS C   I+ +V+R   G   CP         G       E      L  C    T  R   +      +CPE       CK+     DI+ H  +C      C     GC + K+                 K+ + +    R    G T    E+ E+   +++  +S  E +   +         N         LK +  DK       +V ++ +     +   +E A  + A  ++L R   +     EL V  +E+ +++ ++    G+F W ++    KR++       +MFS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ ++++
Sbjct:   37 CSDCKNLLRRPLQAQCGHRYCSHCLNKIIRWVARNWGGVPECPAVCERSDWTGALISVGHEGKCPYLLAPCPACKTIIRAANRDLHSERECPERKLNCRYCKLSFYFPDIKAHDEICPKFPMTCE----GCGRKKI--------------PREKVRLFVCMPCRYAAVGCT----EMVENDKCLEHENKSLAEHLAKGSPAPPANAPPNNSAKVAEMLLKFDTLDKKNTTFENIVSVLNREVERSSHAAEELARQLRAADTRLERTLGQ----KELIVAELETRMQESELSTYDGVFIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQ 390
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Xenopus
Match: egf (epidermal growth factor [Source:Xenbase;Acc:XB-GENE-951823])

HSP 1 Score: 55.8398 bits (133), Expect = 8.950e-8
Identity = 34/113 (30.09%), Postives = 46/113 (40.71%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNC 455
            Y+ E +  +    +C +C   L  A Q+ CG RFC  CI+  +      CP       E  L        D    R+I  +RVKCP + C    EL  +E HL  C      C
Sbjct:   58 YDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACILKSIRDAGHKCPVDNESLMENQL------FPDNFAKREILSLRVKCPSQGCTETMELRHLERHLVRCDFAGVEC 164
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 51.9878 bits (123), Expect = 1.548e-6
Identity = 32/136 (23.53%), Postives = 64/136 (47.06%), Query Frame = 3 
Query:  795 ETKTKQECAEIVTAEGSKLRRDFQEFQERIELKVQNIESYLKQ-KIDETSGIFSWNVNGISAKRKEN-----QSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNR 1184
            + +  QE  E +T +  +L R   +     EL V  +E+ +++ ++    G+F W ++    KR++       +MFS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ ++++
Sbjct:  286 QLRAAQEKVEALTTKVRQLERTLGQ----KELIVAELETRMQESELSTYDGVFIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQ 417
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Xenopus
Match: sytl2 (synaptotagmin like 2 [Source:Xenbase;Acc:XB-GENE-945155])

HSP 1 Score: 51.6026 bits (122), Expect = 1.816e-6
Identity = 35/126 (27.78%), Postives = 61/126 (48.41%), Query Frame = 3 
Query:  159 CDLCKNLLVNACQ-SRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTI-CSNIHTDYRVNRKIAKMRVKC--PEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQN 524
            C LC   +    Q S CG RFC  C+ +++S G   CP       E+ L +  + I+ D  +  ++  + ++C   EE C+   +L  ++ HL +C      CP     C+  K++ +DL  H+Q+
Sbjct:   18 CPLCGKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP-------EDQLPLDYAKIYPDRDLETQVMGLSIRCIHSEEGCRWSGQLKQLQPHLNICAFNVIPCPN---RCST-KLIRRDLPEHMQH 132
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Match: Traf2 (TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835])

HSP 1 Score: 62.7734 bits (151), Expect = 4.295e-10
Identity = 94/421 (22.33%), Postives = 153/421 (36.34%), Query Frame = 3 
Query:  159 CDLCKNLLVNACQSRCGCRFCSKCIMDYVSRG----------NLY----------------------------CPG------GT----SECKEEN----LTICSNIHTDYRVNRKIAKMRVKCPEET-----CKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLXXXXXXXXXXXXXXXXXXXXXL--KIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEG-SKLRRDFQEFQERIELKVQNIE----------SYLKQKIDET-----SGIFSWNVNGISAKRKE-----NQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVN 1181
            C  CKN+L    Q++CG R+CS C+   +S G           LY                            CP       GT      C E      LT C       R++ K      +CP+ +     C+  C  VD+E H  +C       P    GC + K+  +   +H++              S  R      T    E+ E  NL  +  Q   E + L+ S     +            L  + ++ ++ +   E I     +  +  A  VTAE  S+  R  Q+  E +  KVQ +E          + L+QK+ E       G+F W ++  + KR+E       ++FS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ +++
Sbjct:   34 CSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRLSEKEHHTEQECPKRSLSCQHCRAPCSHVDLEVHYEVCP----KFPLTCDGCGKKKIPRETFQDHVR------------ACSKCRVLCRFHTVGCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPELLQRCQILEQKIATFENIVCVLNREVERVA--VTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLD 436
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Match: Traf2 (TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835])

HSP 1 Score: 57.7658 bits (138), Expect = 1.993e-8
Identity = 72/322 (22.36%), Postives = 125/322 (38.82%), Query Frame = 3 
Query:  300 LTICSNIHTDYRVNRKIAKMRVKCPEET-----CKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLXXXXXXXXXXXXXXXXXXXXXL--KIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEG-SKLRRDFQEFQERIELKVQNIE----------SYLKQKIDET-----SGIFSWNVNGISAKRKE-----NQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVN 1181
            LT C       R++ K      +CP+ +     C+  C  VD+E H  +C       P    GC + K+  +   +H++              S  R      T    E+ E  NL  +  Q   E + L+ S     +            L  + ++ ++ +   E I     +  +  A  VTAE  S+  R  Q+  E +  KVQ +E          + L+QK+ E       G+F W ++  + KR+E       ++FS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ +++
Sbjct:  140 LTECPACKGLVRLSEKEHHTEQECPKRSLSCQHCRAPCSHVDLEVHYEVCP----KFPLTCDGCGKKKIPRETFQDHVR------------ACSKCRVLCRFHTVGCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPELLQRCQILEQKIATFENIVCVLNREVERVA--VTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLD 443
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Match: Traf6 (TNF receptor-associated factor 6 [Source:MGI Symbol;Acc:MGI:108072])

HSP 1 Score: 53.1434 bits (126), Expect = 5.479e-7
Identity = 32/114 (28.07%), Postives = 50/114 (43.86%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCP 458
            Y+ E +  +    +C +C   L  A Q+ CG RFC  CI+  +      CP       +  + + + +  D    R+I  + VKCP + C    EL  +E+H   C     NCP
Sbjct:   56 YDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCP------VDNEILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Match: Pdzrn3 (PDZ domain containing RING finger 3 [Source:MGI Symbol;Acc:MGI:1933157])

HSP 1 Score: 51.2174 bits (121), Expect = 2.912e-6
Identity = 38/137 (27.74%), Postives = 61/137 (44.53%), Query Frame = 3 
Query:  132 EGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPG---GTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEET--CKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNG 527
            +G V  +LKC LC  +L +   + CG  FC+ C++ +V +    CP    G    KE N  +         + R I K+ +KC      C    +L D+ EHL  C      C     GC Q  ++ +D+  H+++ 
Sbjct:    9 DGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEG-SCPARCRGRLSAKELNHVLP--------LKRLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARCRH--AGCGQ-LLLRRDVEAHMRDA 133
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|P39429|TRAF2_MOUSE (TNF receptor-associated factor 2 OS=Mus musculus OX=10090 GN=Traf2 PE=1 SV=1)

HSP 1 Score: 62.7734 bits (151), Expect = 3.004e-9
Identity = 94/421 (22.33%), Postives = 153/421 (36.34%), Query Frame = 3 
Query:  159 CDLCKNLLVNACQSRCGCRFCSKCIMDYVSRG----------NLY----------------------------CPG------GT----SECKEEN----LTICSNIHTDYRVNRKIAKMRVKCPEET-----CKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLXXXXXXXXXXXXXXXXXXXXXL--KIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEG-SKLRRDFQEFQERIELKVQNIE----------SYLKQKIDET-----SGIFSWNVNGISAKRKE-----NQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVN 1181
            C  CKN+L    Q++CG R+CS C+   +S G           LY                            CP       GT      C E      LT C       R++ K      +CP+ +     C+  C  VD+E H  +C       P    GC + K+  +   +H++              S  R      T    E+ E  NL  +  Q   E + L+ S     +            L  + ++ ++ +   E I     +  +  A  VTAE  S+  R  Q+  E +  KVQ +E          + L+QK+ E       G+F W ++  + KR+E       ++FS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ +++
Sbjct:   34 CSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRLSEKEHHTEQECPKRSLSCQHCRAPCSHVDLEVHYEVCP----KFPLTCDGCGKKKIPRETFQDHVR------------ACSKCRVLCRFHTVGCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPELLQRCQILEQKIATFENIVCVLNREVERVA--VTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLAMADLEQKVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLD 436
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|Q28DL4|TRAF6_XENTR (TNF receptor-associated factor 6 OS=Xenopus tropicalis OX=8364 GN=traf6 PE=2 SV=1)

HSP 1 Score: 55.8398 bits (133), Expect = 4.910e-7
Identity = 34/113 (30.09%), Postives = 46/113 (40.71%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNC 455
            Y+ E +  +    +C +C   L  A Q+ CG RFC  CI+  +      CP       E  L        D    R+I  +RVKCP + C    EL  +E HL  C      C
Sbjct:   58 YDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACILKSIRDAGHKCPVDNESLMENQL------FPDNFAKREILSLRVKCPSQGCTETMELRHLERHLVRCDFAGVEC 164
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|Q3ZCC3|TRAF6_BOVIN (TNF receptor-associated factor 6 OS=Bos taurus OX=9913 GN=TRAF6 PE=2 SV=1)

HSP 1 Score: 55.4546 bits (132), Expect = 7.022e-7
Identity = 33/114 (28.95%), Postives = 50/114 (43.86%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCP 458
            Y+ E +  +    +C +C   L  A Q+ CG RFC  CI+  +      CP       +  + + + +  D    R+I  + VKCP E C    EL  +EEH   C     +CP
Sbjct:   57 YDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCP------VDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEEHQAHCEFALMSCP 164
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|Q6DJN2|TRF6B_XENLA (TNF receptor-associated factor 6-B OS=Xenopus laevis OX=8355 GN=traf6-b PE=2 SV=1)

HSP 1 Score: 55.0694 bits (131), Expect = 8.714e-7
Identity = 32/113 (28.32%), Postives = 50/113 (44.25%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNC 455
            Y+ E +  +    +C +C   L  A Q+ CG RFC  CI+  +      CP       +  + + + +  D    R+I  ++VKCP + C    EL  +E HL  C   S  C
Sbjct:   58 YDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIVKSLRDAGHKCP------VDNEILMENQLFPDNFAKREILSLKVKCPSQGCTETMELRHLERHLGQCQFASVEC 164
[Close]
BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Match: sp|Q9Y4K3|TRAF6_HUMAN (TNF receptor-associated factor 6 OS=Homo sapiens OX=9606 GN=TRAF6 PE=1 SV=1)

HSP 1 Score: 54.6842 bits (130), Expect = 1.099e-6
Identity = 32/114 (28.07%), Postives = 50/114 (43.86%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCP 458
            Y+ E +  +    +C +C   L  A Q+ CG RFC  CI+  +      CP       +  + + + +  D    R+I  + VKCP E C    EL  +E+H   C     +CP
Sbjct:   56 YDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCP------VDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCP 163
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: I1ZID8 (TNF receptor associated factor-2 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 414.075 bits (1063), Expect = 9.693e-142
Identity = 197/198 (99.49%), Postives = 198/198 (100.00%), Query Frame = 3 
Query:   81 MTAEKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMML 674
            MTAEKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIM+YVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMML
Sbjct:    1 MTAEKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMEYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMML 198
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: I1ZID7 (TNF receptor associated factor-3 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 412.535 bits (1059), Expect = 5.245e-141
Identity = 203/204 (99.51%), Postives = 203/204 (99.51%), Query Frame = 3 
Query:  738 LKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEGSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCNYNWSDPFYFCYDELSGAGLLLNDSFTIECFVDEI 1349
            LKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAE SKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCNYNWSDPFYFCYDELSGAGLLLNDSFTIECFVDEI
Sbjct:   13 LKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEVSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCNYNWSDPFYFCYDELSGAGLLLNDSFTIECFVDEI 216
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: T1E101 (TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 126.331 bits (316), Expect = 6.330e-28
Identity = 101/411 (24.57%), Postives = 185/411 (45.01%), Query Frame = 3 
Query:   75 FPMTAEKINRLLITYNFE-VEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEGS---KLRRDFQEFQERIELKVQNIE--------SYLKQKIDETSGI-------------------------------FSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIV 1178
             P   + +  LL  YN + V+  V ++L C LC  L+ +AC+S CGC +C  CI  Y+S+ + YCPG  +ECKE+ L +  ++  + R++ +I+++ VKCP   C    EL+ ++EHL  CT +S  CP   +GC +  ++  ++  HL +   +H++LI+   + ++++   +       +EDI+ +K   + Q  +             +      EF   ++  +D M+ LV    + E K   E   ++T++ S   KL+ D Q F++ IE    ++E        + +K    E  GI                               F W +   S KR+    ++S+ F +   K  ++L    +           ++  I  G ++  L WP +  VT+ I+
Sbjct:    2 IPSKLDNVQELLSKYNVKRVDESVNNDLLCILCNKLMRDACESACGCHYCYTCIRIYLSQNHNYCPGDKTECKEDYLNLEGDVFRNIRLSTRISRIVVKCPNIRCNYTSELLRLKEHLDKCTPESVECPCVTIGCEEEPLLKDEMAKHLTDQVLRHTQLIMSFCNELKSE---INHNNETTKEDISHLKEVLRVQKAL------------NDEKTAQMEFLIEELRNKDNMI-LVLSQDIQEVKN--EMITLLTSKESELKKLKSDIQIFRQEIEFMKNDLEVVGSTDIKNQVKDLKKEIFGIKMNIDSNNEERERKMNNLIRLNKLCPNVDMDFMWRIEEYSKKRRTVTDVYSDSFQSHNYKFCLNLYIYGD--------NLGLWCVIMKGEKDDFLEWPMRRTVTLSII 386
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: A0A482WS30 (Uncharacterized protein OS=Laodelphax striatellus OX=195883 GN=LSTR_LSTR010845 PE=4 SV=1)

HSP 1 Score: 92.0485 bits (227), Expect = 6.793e-16
Identity = 87/349 (24.93%), Postives = 154/349 (44.13%), Query Frame = 3 
Query:  153 LKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCP-GGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKS----QNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEGSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAK----RKENQSMF-SEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTI 1169
             +C +C N L +   + CG RFC  CI+ ++ R    CP  G S      LT+ S++  D    R+IA+ R++CP E C     LVD E+H+      +      C F  +GCN   M ++ +  HL N    H  LI  + S       GL+++         L  N   S+ E   L        + ++ +  +   + + ++++ + +L E+I L E KT+++  ++  A          +   R+ +++  ++S L  ++    G + WN++    K    + E   MF S  FYT    ++   +   NVS D + I  NV   +  G  +  L WPF   +++
Sbjct:   28 FECPICLNCLKDPFLTSCGHRFCKDCIIQWMKRQGGVCPIDGYS------LTMESDLFPDNYTRREIAQQRLRCPVEDCTQVLSLVDAEQHMSEHHPSNCEDCMRCSFHNVGCNFIAMSVEHMKMHLNNDLHNHLSLISSVCS-------GLSSR---------LTNNAITSKAEEAKL-----WDPRPKHDDSDSTSSSEESQLKELVKNLFERIVLLEQKTREQDVQLTGA---------HQHIVRLSVEIDRLKSDLPLRV--CGGAYVWNISDFRRKLQKMKLEPSIMFYSPGFYTSYHGYRFCARLNLNVS-DTSFITLNV--HVMQGENDRVLQWPFIGRISL 335
[Close]
BLAST of TNF receptor associated factor-2 vs. TrEMBL
Match: A0A0F7GWW3 (TNF receptor associated factor 4 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 1.028e-12
Identity = 43/115 (37.39%), Postives = 67/115 (58.26%), Query Frame = 3 
Query:  315 NIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDF-------FGLTTKEVELREDINLIK 638
            NI  DY +N KIAK++VKC E++C    EL  +E+H R C  +S  CP+  +GC++  +    +T+HLQ+  F H+KL++D + N  N+         GL+     LR +IN +K
Sbjct:   15 NICVDYPMNMKIAKLQVKCKEKSCDYVDELRKMEDHSRTCKYRSVACPYSNIGCDKCNISQDKVTDHLQSEIFVHTKLLMDFVVNFNNEMEMLKANNNGLSPVNELLRNEINELK 129
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf1 (TNF receptor-associated factor 1-like [Source:NCBI gene;Acc:103045252])

HSP 1 Score: 52.7582 bits (125), Expect = 5.661e-7
Identity = 42/137 (30.66%), Postives = 64/137 (46.72%), Query Frame = 3 
Query:  144 PDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGN--LYC------PGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQD-LTNHLQNG 527
            P +  C  C N+L  A Q++CG R+C  C+M ++ R N  L C      PG  SE     +    +  +D  +N++I ++RV C  + C     L D E+H   C      C    +GC    MV++  L  HL+ G
Sbjct:   24 PVHFLCSSCNNVLNEAHQTQCGHRYCRACVM-WLLRNNKDLICTKCKEDPG--SESDSSMMLTLDHFFSDNAINKEIQELRVHCVNQGCGWRSTLKDFEDHQSQCEYALIPC---NIGCG--LMVLRKTLATHLEKG 152
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf1 (TNF receptor-associated factor 1-like [Source:NCBI gene;Acc:103045252])

HSP 1 Score: 51.9878 bits (123), Expect = 8.742e-7
Identity = 42/137 (30.66%), Postives = 64/137 (46.72%), Query Frame = 3 
Query:  144 PDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGN--LYC------PGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQD-LTNHLQNG 527
            P +  C  C N+L  A Q++CG R+C  C+M ++ R N  L C      PG  SE     +    +  +D  +N++I ++RV C  + C     L D E+H   C      C    +GC    MV++  L  HL+ G
Sbjct:   24 PVHFLCSSCNNVLNEAHQTQCGHRYCRACVM-WLLRNNKDLICTKCKEDPG--SESDSSMMLTLDHFFSDNAINKEIQELRVHCVNQGCGWRSTLKDFEDHQSQCEYALIPC---NIGCG--LMVLRKTLATHLEKG 152
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf2a (TNF receptor-associated factor 2-like [Source:NCBI gene;Acc:103036375])

HSP 1 Score: 50.8322 bits (120), Expect = 1.893e-6
Identity = 26/106 (24.53%), Postives = 51/106 (48.11%), Query Frame = 3 
Query:  885 ELKVQNIESYLKQKIDET-SGIFSWNVNGISAKRKEN-----QSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNR 1184
            +L +  +E  +++    T  G+F W ++  S KR++       +MFS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ ++++
Sbjct:  290 DLSIVEMEGKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 395
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf2a (TNF receptor-associated factor 2-like [Source:NCBI gene;Acc:103036375])

HSP 1 Score: 51.2174 bits (121), Expect = 1.952e-6
Identity = 26/106 (24.53%), Postives = 51/106 (48.11%), Query Frame = 3 
Query:  885 ELKVQNIESYLKQKIDET-SGIFSWNVNGISAKRKEN-----QSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNR 1184
            +L +  +E  +++    T  G+F W ++  S KR++       +MFS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ ++++
Sbjct:  403 DLSIVEMEGKMREMSAATYDGVFVWKISDFSKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 508
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:103024022])

HSP 1 Score: 49.2914 bits (116), Expect = 6.257e-6
Identity = 34/128 (26.56%), Postives = 58/128 (45.31%), Query Frame = 3 
Query:  153 LKCDLCKNLLVNACQ-SRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTI-CSNIHTDYRVNRKIAKMRVKC--PEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQN 524
             +C LC   +    Q S CG RFC  C+ +++S G   CP       E+ L +  + I+ D  + ++I  + ++C   EE C+   ++  ++ H   C      CP         K+  +DL  HLQ+
Sbjct:   16 FQCPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP-------EDQLPLDYAKIYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQGHFSTCAFNVIPCPNRCAV----KLTRRDLPEHLQH 132

HSP 2 Score: 48.9062 bits (115), Expect = 7.921e-6
Identity = 29/106 (27.36%), Postives = 51/106 (48.11%), Query Frame = 3 
Query:  915 LKQKIDETS----GIFSWNVNGISAKRKE-----NQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSK 1205
            L+++++E S    G+  W +N  S K +E     N   FS  FYT    +K+ +    N +        ++++ +  G  ++ L WPF   VT  I+++S P  SK
Sbjct:  295 LRREMEELSVSHDGVLIWKLNDYSRKLQEAKLHNNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSIYIRVLPGEYDNLLEWPFAYKVTFSILDQSDPSLSK 400
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Match: EDO41243 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4Z7])

HSP 1 Score: 53.1434 bits (126), Expect = 1.260e-7
Identity = 42/136 (30.88%), Postives = 59/136 (43.38%), Query Frame = 3 
Query:  117 YNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECK--EENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHL 518
            Y+ E    V +   C +C   L    Q++CG RFC +C +D  SR         +EC    E L +  ++  D    R I    VKCP + CK   EL D+E H R C  +   C   +     P+M   D+  HL
Sbjct:   11 YDSEFVIAVAEEYTCRICHLPLRVPVQTKCGHRFCKEC-LDEASRRK-----SRAECPMDREPLDLKKDVFLDKAAERTILSFLVKCPCKGCKWEAELRDLEAHARNCDYELVTCSNPMCSAQLPRM---DVDEHL 137
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Match: EDO35237 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM27])

HSP 1 Score: 52.7582 bits (125), Expect = 2.174e-7
Identity = 33/137 (24.09%), Postives = 64/137 (46.72%), Query Frame = 3 
Query:  870 FQERIELKVQNIESYLKQKIDETSGIFSWNVNGIS-----AKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCNYNWSDP 1265
            FQE + +++Q   SY         G F W ++  +     AK     S++S  FYT    +K+  +   N      +   ++F+ +  G  +S L WPFQ  +TI ++++   D+   +++ F  +  PC+ ++  P
Sbjct:  364 FQEDLRIQIQQAISY--------DGTFLWKIDKFTERYAEAKSGNATSIYSSPFYTHRFGYKLCARLFPNGDGSARDNYLSIFIALMRGEYDSILPWPFQETITITLIDQ---DNGMNISETF--DPDPCSISFQRP 487
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Match: EDO48394 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJK8])

HSP 1 Score: 47.7506 bits (112), Expect = 7.648e-6
Identity = 33/125 (26.40%), Postives = 59/125 (47.20%), Query Frame = 3 
Query:  147 DNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYV-SRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCN--QPKMVIQDLTN 512
            D L C +C  ++     + CG  +C  CI  +   +  + CP    + K       S I  D + +R +  + VKC    C+   EL   ++HL++C+ K+  C   + GCN   P+++++  TN
Sbjct:   26 DELICAICHMVVNEPVLTSCGHSYCKYCIEKWCNGKEVVTCPVDNEQLKP------SQIFPDKKTDRIVLSLEVKCTNNPCRWKGELRQKQKHLKICSHKAVKC--ILEGCNVKVPRILMEKHTN 142
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Medaka
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:101161132])

HSP 1 Score: 55.8398 bits (133), Expect = 5.687e-8
Identity = 38/126 (30.16%), Postives = 52/126 (41.27%), Query Frame = 3 
Query:  108 LITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQP 485
            L  Y+ E +  +    +C +C   L NA Q+RCG RFC  CI   +      CP       E+ L        D    R+I  + V+CP   C    EL  +E+HL  C   +  C      C QP
Sbjct:   61 LQGYDVEFDPPLESKYECPICLMALRNAIQTRCGHRFCKSCIEKSIRDTGQRCPVDNEMLSEDQL------FPDNFAKREILSLTVRCPNSDCGEKMELRHLEKHLAQCQFATVPC----SQCQQP 176
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Medaka
Match: unm_sa808 (TNF receptor-associated factor 2 [Source:NCBI gene;Acc:101155367])

HSP 1 Score: 55.8398 bits (133), Expect = 6.591e-8
Identity = 28/107 (26.17%), Postives = 53/107 (49.53%), Query Frame = 3 
Query:  885 ELKVQNIESYLKQKIDET-SGIFSWNVNGISAKRKEN-----QSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRS 1187
            +L V  +E  L++    T  G+F W ++  + KR++       +MFS  FYT    +K+ L+   N          ++F  +  G+ ++ L WPF   VT+ ++++S
Sbjct:  427 DLTVAEMEGRLREMAATTFDGVFIWRISDFAKKRQDAVAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGLSDALLKWPFNQKVTLMLLDQS 533
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Medaka
Match: ENSORLT00000020861.2 (TNF receptor-associated factor 2 [Source:NCBI gene;Acc:101167626])

HSP 1 Score: 50.447 bits (119), Expect = 2.963e-6
Identity = 27/106 (25.47%), Postives = 50/106 (47.17%), Query Frame = 3 
Query:  885 ELKVQNIESYLKQKIDET-SGIFSWNVNGISAKRKENQS-----MFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNR 1184
            +L +  +E  +K     T  GIF W ++  + KR++  +     MFS  FYT    +K+ L+   N          ++F  +  G  ++ L WPF   VT+ ++++
Sbjct:  400 DLSIVEMEGKMKDMSAATYDGIFIWKISDFTKKRQDAMAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGHSDALLKWPFNQKVTLMLLDQ 505
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Medaka
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:101161428])

HSP 1 Score: 50.447 bits (119), Expect = 3.118e-6
Identity = 30/106 (28.30%), Postives = 51/106 (48.11%), Query Frame = 3 
Query:  915 LKQKIDETS----GIFSWNVNGIS-----AKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSK 1205
            L+++++E S    G+  W +N  S     AK + N   FS  FYT    +K+ +    N +        +V++ +  G  ++ L WPF   VT  I+++S P  SK
Sbjct:  295 LRREMEELSVSHDGVLIWKLNDYSRKLQEAKLRSNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSVYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSK 400

HSP 2 Score: 49.2914 bits (116), Expect = 5.901e-6
Identity = 34/128 (26.56%), Postives = 59/128 (46.09%), Query Frame = 3 
Query:  153 LKCDLCKNLLVNACQ-SRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTI-CSNIHTDYRVNRKIAKMRVKC--PEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQN 524
             +C LC   +    Q S CG RFC  C+ +++S G   CP       E+ L +  + I+ D  + ++I  + ++C   EE C+   ++  ++ H   C      CP         K+  +DL +HLQ+
Sbjct:   16 FQCPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP-------EDQLPLDYAKIYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQGHFSTCAFNVIPCPNRC----SVKLTRRDLPDHLQH 132
[Close]
BLAST of TNF receptor associated factor-2 vs. Ensembl Medaka
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:101161428])

HSP 1 Score: 50.0618 bits (118), Expect = 3.690e-6
Identity = 30/106 (28.30%), Postives = 51/106 (48.11%), Query Frame = 3 
Query:  915 LKQKIDETS----GIFSWNVNGIS-----AKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSK 1205
            L+++++E S    G+  W +N  S     AK + N   FS  FYT    +K+ +    N +        +V++ +  G  ++ L WPF   VT  I+++S P  SK
Sbjct:  295 LRREMEELSVSHDGVLIWKLNDYSRKLQEAKLRSNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSVYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSK 400

HSP 2 Score: 49.2914 bits (116), Expect = 5.707e-6
Identity = 35/128 (27.34%), Postives = 61/128 (47.66%), Query Frame = 3 
Query:  153 LKCDLCKNLLVNACQ-SRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTI-CSNIHTDYRVNRKIAKMRVKC--PEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQN 524
             +C LC   +    Q S CG RFC  C+ +++S G   CP       E+ L +  + I+ D  + ++I  + ++C   EE C+   ++  ++ H   C      CP     C+  K+  +DL +HLQ+
Sbjct:   16 FQCPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP-------EDQLPLDYAKIYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQGHFSTCAFNVIPCPN---RCSV-KLTRRDLPDHLQH 132
[Close]
BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024584.1 (SMESG000024584.1)

HSP 1 Score: 813.913 bits (2101), Expect = 0.000e+0
Identity = 421/423 (99.53%), Postives = 422/423 (99.76%), Query Frame = 3 
Query:   81 MTAEKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEGSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCNYNWSDPFYFCYDELSGAGLLLNDSFTIECFVDEI 1349
            MTAEKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIM+YVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLINSEIEIIKKENIECINEFKNLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAE SKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCNYNWSDPFYFCYDELSGAGLLLNDSFTIECFVDEI
Sbjct:    1 MTAEKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMEYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLINSEIEIIKKENIECINEFKNLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEVSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCNYNWSDPFYFCYDELSGAGLLLNDSFTIECFVDEI 423
[Close]
BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024548.1 (SMESG000024548.1)

HSP 1 Score: 241.121 bits (614), Expect = 2.037e-74
Identity = 138/427 (32.32%), Postives = 242/427 (56.67%), Query Frame = 3 
Query:   99 NRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNH--------FQSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEGSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTK-CF--RIEEPPCNYNWSDPFYFCYDELSGAGLLLNDSFTIECFVDE 1346
            ++LL  +  E+   +  +L C +C+ +L++ACQSRCGC FC  C+ +Y+  GN  CPG T ECK E+L    +I TDY+VN+ I+K+ VKC E  C   CEL+++E+HLRLC  KS  CP+F +GC+  K+VI+++++HL      HSKL++D I +++N+   +       + +I  ++          ++  +EI +L  +    + +      +  + L+    + ++D V++ KL E K  QE    V  +  +++ D  E  +RI +    +E Y+ +K+ +  G+F W+VN I++KR +   ++SE+F+TK + +++ L   AN S  + ++G  + L  +  + +  L WPF   VTI ++N++ P     VTK CF  R +E   ++ W+D F F Y++L    +  +D F +EC V +
Sbjct:   24 HKLLQLHQLEIYSDLSSDLICGMCEKILIDACQSRCGCSFCRNCVNEYLLTGNETCPGNTDECKTESLL---SIQTDYKVNKIISKLIVKCTETLCCYKCELINLEDHLRLCPKKSAKCPYFDIGCSVEKIVIEEMSDHLIKENCNHSKLMVDAIGSLKNEVSNIKRTSDTYKMEIETLRETLKRNEEFIYKISDEIQILKTNSFNKLSQFEDSIQSIKEKLERNELNLLIDRVQQ-KLEE-KFLQE----VHQKIDEMKYDKIEMVKRISV----VEKYMDEKLKKALGLFVWDVNDITSKRNKFGYLWSEHFFTKPNFYRMRLHLCANGSGAVKDVGLTLLLCSYPSVNDEFLTWPFSKEVTITLINKNDPLIKSCVTKMCFLNRPKENSYSFEWNDSFDFVYNDLISNNVFTDDGFIVECQVKD 437
[Close]
BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024592.1 (SMESG000024592.1)

HSP 1 Score: 220.32 bits (560), Expect = 7.048e-67
Identity = 128/411 (31.14%), Postives = 220/411 (53.53%), Query Frame = 3 
Query:  120 NFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHF-QSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEGSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEP--PCNYNWSDPFYFCYDELSGAGLLLNDSFTIECFVD 1343
            +FE    + ++LKC LC+ +L+NA QS CGC FC KCI +++      CPG + ECK++ LT   N+  DY+ N ++ K+ VKCPE+TC   C+L +++ HLR C+ KS  CP++ LGC++  +    + +H+Q+  + H+ +I+ I + M+     L   E    E+I  +KN   + +N+I  L      +  K N +       L   + +   D  +K+K A           V     K R+D       I L+  +   Y ++  D  +G   W++  I+  RK+  S+ SEYFY   +K+K+ L   AN + ++   G +++++I+   + SK++WPF+  VTIK++N+    +S        +++    C+Y W + F F Y+ELS +G+L N+  T+EC V+
Sbjct:    4 DFEAIENISEDLKCTLCEKILMNAYQSPCGCSFCQKCIEEFIQNEPKLCPGKSEECKQQFLT---NLQIDYKANNRVQKLIVKCPEKTCLYKCKLSNMDNHLRFCSKKSVKCPYYDLGCDEVAIATDKVIDHIQSEIYSHNSMILGINNQMKQSIEMLAHHEEIHEENITSLKNSLKEKENQIESLKREVEILTNKINEKVDQNALTLNAILLEMSKDFDQKLKQA--------IYSVNESNEKYRKD-------ILLRFNDPGKYDEEHFDSVAGSILWSIEKINKCRKKGGSVESEYFYLGYNKYKMKLLLYANGTGNVTGSGLSIYIYIYPCTKHSKVDWPFKGLVTIKVLNKLDTFASVKQKGSLFMDDSIDSCDYQWDNQFDFLYNELSASGVLDNNIITVECNVE 396
[Close]
BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024592.1 (SMESG000024592.1)

HSP 1 Score: 218.779 bits (556), Expect = 5.641e-66
Identity = 133/437 (30.43%), Postives = 228/437 (52.17%), Query Frame = 3 
Query:   90 EKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHF-QSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEGSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNR-----SVPDSSKIVTKCFR--IEEP-----------PCNYNWSDPFYFCYDELSGAGLLLNDSFTIECFVD 1343
            + I  L++  +FE    + ++LKC LC+ +L+NA QS CGC FC KCI +++      CPG + ECK++ LT   N+  DY+ N ++ K+ VKCPE+TC   C+L +++ HLR C+ KS  CP++ LGC++  +    + +H+Q+  + H+ +I+ I + M+     L   E    E+I  +KN   + +N+I  L      +  K N +       L   + +   D  +K+K A           V     K R+D       I L+  +   Y ++  D  +G   W++  I+  RK+  S+ SEYFY   +K+K+ L   AN + ++   G +++++I+   + SK++WPF+  VTIK++N+     SV  S   +   F   +++             C+Y W + F F Y+ELS +G+L N+  T+EC V+
Sbjct:    8 DSIFELIMKNDFEAIENISEDLKCTLCEKILMNAYQSPCGCSFCQKCIEEFIQNEPKLCPGKSEECKQQFLT---NLQIDYKANNRVQKLIVKCPEKTCLYKCKLSNMDNHLRFCSKKSVKCPYYDLGCDEVAIATDKVIDHIQSEIYSHNSMILGINNQMKQSIEMLAHHEEIHEENITSLKNSLKEKENQIESLKREVEILTNKINEKVDQNALTLNAILLEMSKDFDQKLKQAIYS--------VNESNEKYRKD-------ILLRFNDPGKYDEEHFDSVAGSILWSIEKINKCRKKGGSVESEYFYLGYNKYKMKLLLYANGTGNVTGSGLSIYIYIYPCTKHSKVDWPFKGLVTIKVLNKLDTFASVKQSKYCIIDNFEEGLDDAEGSLFMDDSIDSCDYQWDNQFDFLYNELSASGVLDNNIITVECNVE 426
[Close]
BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Match: SMESG000024504.1 (SMESG000024504.1)

HSP 1 Score: 209.149 bits (531), Expect = 7.503e-62
Identity = 131/439 (29.84%), Postives = 223/439 (50.80%), Query Frame = 3 
Query:   90 EKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHF-QSQNEIMMLXXXXXXXXXXXXXXXXXXXXXLKIEVEDKMVDLVEKIKLAETKTKQECAEIVTAEGSKLRRDFQEFQERIELKVQNIESYL---KQKIDETS-----------------GIFSWNVNGISAKRKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQESKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCN-YNWSDPFYFCYDELSGAGLLLNDSFTIECFV 1340
            +++ ++L  Y+F++E    D  KC++CK +L NACQ  CGCR+CSKC  D ++  + +CPG +  CK+  L   +NI  D+R+N ++ KM VKCP + C    EL D+++HLR+C+ K   CPF   GC   K+    +  +L++  F HSK++I++ISN++ND   L   +++   D+  I+N   +++ +I +L                       I+++ +   L E +    TK K +  +  ++E   +R   + F +  +L    ++ Y    + +ID+T                     SW++  +S ++K+N    S +FY    +HK++L F AN           +F  + S  ++S L WPF   + I++ N    +SS  + K   ++ P  N +  SDPF F Y+EL   GLL +D   IECFV
Sbjct:   47 QRMFKILNKYDFKIERSNSDEYKCEICKRILCNACQGECGCRYCSKCFADLLNSESKFCPGNSELCKDLQLAE-NNIQIDHRMNNELLKMVVKCPNKLCSFETELKDMDKHLRVCSSKVDKCPFHQFGCGHDKVKCSKMDEYLKDEIFSHSKILIEVISNIKNDTSELWNMKIKYENDLKTIQNELVENREQIQILRQEV-------------------IKLKSENSALSESVSYLTTKVKNK-VQSNSSESDSIRLSDKSFIDDKKLLENLLKIYYENPRNEIDDTKTKCELNTSIETSNYKIIANISWDIERLSERKKKNNWAKSNFFYANGDQHKLNLTFWANGYEKSVGNCATIFFRVISSQKDSSLTWPFITKIKIRLTNNYSLESSLELEKLCDLKMPNSNSFICSDPFDFSYNELFTLGLLRHDCLRIECFV 464
The following BLAST results are available for this feature:
BLAST of TNF receptor associated factor-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
TRAF27.863e-1020.91TNF receptor associated factor 2 [Source:HGNC Symb... [more]
TRAF31.311e-720.58TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF62.289e-728.07TNF receptor associated factor 6 [Source:HGNC Symb... [more]
TRAF62.289e-728.07TNF receptor associated factor 6 [Source:HGNC Symb... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor associated factor-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Traf63.597e-724.31gene:FBgn0265464 transcript:FBtr0071188[more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf33.287e-833.61TNF receptor-associated factor 3 [Source:ZFIN;Acc:... [more]
unm_sa8081.225e-726.17un-named sa808 [Source:ZFIN;Acc:ZDB-GENE-120727-21... [more]
traf2a1.718e-624.53Tnf receptor-associated factor 2a [Source:ZFIN;Acc... [more]
traf63.014e-629.82TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf63.014e-629.82TNF receptor-associated factor 6 [Source:NCBI gene... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
TRAF24.295e-1121.84TNF receptor associated factor 2 [Source:NCBI gene... [more]
egf8.950e-830.09epidermal growth factor [Source:Xenbase;Acc:XB-GEN... [more]
TRAF21.548e-623.53TNF receptor associated factor 2 [Source:NCBI gene... [more]
sytl21.816e-627.78synaptotagmin like 2 [Source:Xenbase;Acc:XB-GENE-9... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Traf24.295e-1022.33TNF receptor-associated factor 2 [Source:MGI Symbo... [more]
Traf21.993e-822.36TNF receptor-associated factor 2 [Source:MGI Symbo... [more]
Traf65.479e-728.07TNF receptor-associated factor 6 [Source:MGI Symbo... [more]
Pdzrn32.912e-627.74PDZ domain containing RING finger 3 [Source:MGI Sy... [more]
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BLAST of TNF receptor associated factor-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P39429|TRAF2_MOUSE3.004e-922.33TNF receptor-associated factor 2 OS=Mus musculus O... [more]
sp|Q28DL4|TRAF6_XENTR4.910e-730.09TNF receptor-associated factor 6 OS=Xenopus tropic... [more]
sp|Q3ZCC3|TRAF6_BOVIN7.022e-728.95TNF receptor-associated factor 6 OS=Bos taurus OX=... [more]
sp|Q6DJN2|TRF6B_XENLA8.714e-728.32TNF receptor-associated factor 6-B OS=Xenopus laev... [more]
sp|Q9Y4K3|TRAF6_HUMAN1.099e-628.07TNF receptor-associated factor 6 OS=Homo sapiens O... [more]
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BLAST of TNF receptor associated factor-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I1ZID89.693e-14299.49TNF receptor associated factor-2 (Fragment) OS=Sch... [more]
I1ZID75.245e-14199.51TNF receptor associated factor-3 (Fragment) OS=Sch... [more]
T1E1016.330e-2824.57TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
A0A482WS306.793e-1624.93Uncharacterized protein OS=Laodelphax striatellus ... [more]
A0A0F7GWW31.028e-1237.39TNF receptor associated factor 4 (Fragment) OS=Sch... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf15.661e-730.66TNF receptor-associated factor 1-like [Source:NCBI... [more]
traf18.742e-730.66TNF receptor-associated factor 1-like [Source:NCBI... [more]
traf2a1.893e-624.53TNF receptor-associated factor 2-like [Source:NCBI... [more]
traf2a1.952e-624.53TNF receptor-associated factor 2-like [Source:NCBI... [more]
traf4a6.257e-626.56TNF receptor associated factor 4 [Source:NCBI gene... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor associated factor-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor associated factor-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO412431.260e-730.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO352372.174e-724.09Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO483947.648e-626.40Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TNF receptor associated factor-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf65.687e-830.16TNF receptor associated factor 6 [Source:NCBI gene... [more]
unm_sa8086.591e-826.17TNF receptor-associated factor 2 [Source:NCBI gene... [more]
ENSORLT00000020861.22.963e-625.47TNF receptor-associated factor 2 [Source:NCBI gene... [more]
traf4a3.118e-628.30TNF receptor associated factor 4 [Source:NCBI gene... [more]
traf4a3.690e-628.30TNF receptor associated factor 4 [Source:NCBI gene... [more]
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BLAST of TNF receptor associated factor-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000024584.10.000e+099.53SMESG000024584.1[more]
SMESG000024548.12.037e-7432.32SMESG000024548.1[more]
SMESG000024592.17.048e-6731.14SMESG000024592.1[more]
SMESG000024592.15.641e-6630.43SMESG000024592.1[more]
SMESG000024504.17.503e-6229.84SMESG000024504.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30016919
GenBankAFJ24792.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30016919 ID=SMED30016919|Name=TNF receptor associated factor-2|organism=Schmidtea mediterranea sexual|type=transcript|length=1418bp
TGTCAACTTTATGAATATAATTGATAGTATGTATACTTTATTTAAGTTTT
GTATCCCTCACCTTCTCTAACGCGTTCCCAATGACAGCTGAAAAGATCAA
CAGATTATTAATCACATATAATTTTGAAGTTGAAGGCGGTGTTCCTGACA
ATCTCAAGTGTGACCTTTGTAAAAATCTTCTTGTCAACGCATGCCAGTCC
CGTTGTGGCTGCCGGTTCTGCTCCAAGTGCATAATGGACTATGTGAGTAG
GGGAAACCTCTATTGTCCGGGTGGAACATCAGAATGCAAAGAAGAAAACT
TAACCATTTGTTCGAACATTCATACAGACTATCGAGTGAATAGAAAAATA
GCGAAAATGCGAGTGAAATGTCCGGAAGAAACTTGCAAAGTCTATTGTGA
ATTGGTCGACATTGAGGAGCATTTGAGATTGTGCACAATGAAGAGCCAAA
ATTGCCCATTTTTTGTTCTCGGCTGCAATCAACCAAAAATGGTAATTCAA
GACCTCACAAACCATTTGCAAAACGGAACATTTCAGCACAGCAAACTCAT
TATTGACATCATCAGCAACATGAGAAATGACTTTTTTGGTCTGACTACGA
AAGAAGTCGAACTTCGAGAAGATATCAATTTAATAAAGAACCATTTCCAG
TCTCAAAATGAGATTATGATGTTAATTAATTCGGAAATTGAAATAATAAA
AAAAGAAAATATTGAATGCATAAATGAATTCAAGAATTTAAAAATTGAAG
TAGAGGATAAAATGGTGGATTTAGTTGAAAAAATCAAATTAGCAGAAACG
AAAACAAAGCAGGAATGTGCGGAAATTGTGACTGCGGAAGGATCAAAACT
CAGAAGAGATTTTCAAGAATTTCAAGAAAGAATTGAATTAAAGGTTCAAA
ATATTGAATCCTATCTGAAACAGAAAATTGATGAAACCTCTGGAATATTT
TCATGGAACGTTAATGGGATTTCGGCAAAACGGAAAGAGAATCAGTCCAT
GTTCAGTGAATACTTCTACACGAAAGTCAGCAAACACAAAGTTAGCCTGC
AGTTCACTGCGAATGTTTCCAATGATATCAACGAAATCGGCTTTAACGTA
TTTTTATTCATTTTTTCTGGCATTCAGGAATCTAAATTAAATTGGCCTTT
TCAAGCAAATGTAACAATCAAAATTGTAAATAGATCTGTTCCGGATTCAA
GCAAAATTGTGACGAAGTGTTTCAGAATTGAAGAGCCTCCGTGCAATTAC
AATTGGAGTGACCCTTTTTATTTTTGTTATGATGAATTGTCTGGCGCTGG
CTTGCTTCTTAATGATAGCTTCACAATTGAATGTTTTGTTGATGAAATTT
AAAGGATCTTGCAGGGTTATCTGTTTAGATTTGAAATATCAAATTATATT
TTTGTTCGTGAAAAACGC
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protein sequence of SMED30016919-orf-1

>SMED30016919-orf-1 ID=SMED30016919-orf-1|Name=SMED30016919-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=424bp
MTAEKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKC
IMDYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEE
TCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGT
FQHSKLIIDIISNMRNDFFGLTTKEVELREDINLIKNHFQSQNEIMMLIN
SEIEIIKKENIECINEFKNLKIEVEDKMVDLVEKIKLAETKTKQECAEIV
TAEGSKLRRDFQEFQERIELKVQNIESYLKQKIDETSGIFSWNVNGISAK
RKENQSMFSEYFYTKVSKHKVSLQFTANVSNDINEIGFNVFLFIFSGIQE
SKLNWPFQANVTIKIVNRSVPDSSKIVTKCFRIEEPPCNYNWSDPFYFCY
DELSGAGLLLNDSFTIECFVDEI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR043211TNF_rcpt-assoc_TRAF
IPR008974TRAF-like
IPR013083Znf_RING/FYVE/PHD
IPR001841Znf_RING
IPR002083MATH/TRAF_dom
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0008270zinc ion binding
GO:0004842ubiquitin-protein transferase activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0006955immune response
GO:0007165signal transduction
GO:0016567protein ubiquitination
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 247..267
NoneNo IPR availableCOILSCoilCoilcoord: 214..241
NoneNo IPR availablePANTHERPTHR10131:SF129TNF RECEPTOR-ASSOCIATED FACTOR 6coord: 11..371
NoneNo IPR availableCDDcd16449RING-HCcoord: 27..63
e-value: 9.69973E-5
score: 37.4469
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 20..75
IPR008974TRAF-likeGENE3DG3DSA:2.60.210.10coord: 259..423
e-value: 2.7E-16
score: 61.6
IPR008974TRAF-likeSUPERFAMILYSSF49599TRAF domain-likecoord: 94..148
IPR008974TRAF-likeSUPERFAMILYSSF49599TRAF domain-likecoord: 287..421
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 9..127
e-value: 3.1E-14
score: 54.9
IPR043211TNF receptor-associated factor TRAFPANTHERPTHR10131TNF RECEPTOR ASSOCIATED FACTORcoord: 11..371
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 27..63
score: 8.919
IPR002083MATH/TRAF domainPROSITEPS50144MATHcoord: 287..420
score: 11.467
IPR002083MATH/TRAF domainCDDcd00121MATHcoord: 288..421
e-value: 8.3298E-7
score: 45.8331