PROX-1

Overview


Name	PROX-1 (AFD29617.1)
Smed ID	SMED30016901
Length (bp)	1564

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of PROX-1 (SMED30016901) t-SNE clustered cells

Violin plots show distribution of expression levels for PROX-1 (SMED30016901) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of PROX-1 (SMED30016901) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for PROX-1 (SMED30016901) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30016901

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30016901	h1SMcG0011161	SmedASXL_010375	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30016901	h1SMcG0011161	SmedASXL_010375	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30016901	h1SMcG0011161	dd_Smed_v4_13772_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30016901	h1SMcG0011161	dd_Smed_v4_13772_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neuron	SMED30016901	h1SMcG0011161	dd_Smed_v4_13772_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30016901	h1SMcG0011161	dd_Smed_v4_13772_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30016901	h1SMcG0011161	dd_Smed_v4_13772_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30016901	h1SMcG0011161	dd_Smed_v4_13772_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gamma neoblast	SMED30016901	h1SMcG0011161	JQ425149.1	smed_ncbi_20240424	PMID:25017721 van Wolfswinkel et al., 2014
neoblast	SMED30016901	h1SMcG0011161	SMED_26251_V2	GPL14150	PMID:22385657 Wagner et al., 2012
neoblast	SMED30016901	h1SMcG0011161	SMED_26251_V2	GPL14150	PMID:22385657 Wagner et al., 2012
neoblast	SMED30016901	h1SMcG0011161	SmWIOct06_019613	GPL14150_gene_models	PMID:22385657 Wagner et al., 2012

Note: Hover over icons to view figure legend

Homology

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BLAST of PROX-1 vs. Ensembl Human
Match: PROX1 (prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9459])

HSP 1 Score: 184.111 bits (466), Expect = 6.781e-50
Identity = 85/162 (52.47%), Postives = 113/162 (69.75%), Query Frame = 3

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  573 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 734

[Close]

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  573 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 734

[Close]

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  573 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 734

[Close]

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  573 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 734

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BLAST of PROX-1 vs. Ensembl Human
Match: PROX2 (prospero homeobox 2 [Source:HGNC Symbol;Acc:HGNC:26715])

HSP 1 Score: 171.4 bits (433), Expect = 4.565e-46
Identity = 80/151 (52.98%), Postives = 108/151 (71.52%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNW 1445
            L P HL+KAKLMF +TRYP+S +LK YFPD+ F +  T+Q++KWFSNFREFYY +MEK+ ++A+S+G+   K + V   SELF+ L  H+NK     VP  FL    +TL+EFF A+SAG++   SWKKPIYK I+KLD  +PE FK  ++
Sbjct:  440 LNPGHLKKAKLMFFFTRYPSSNLLKVYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKSARQAISDGVTNPKMLVVLRNSELFQALNMHYNKGNDFEVPDCFLEIASLTLQEFFRAVSAGRDSDPSWKKPIYKIISKLDSDIPEIFKSSSY 590

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BLAST of PROX-1 vs. Ensembl Celegans
Match: pros-1 (Homeobox protein prospero homolog 1 [Source:UniProtKB/Swiss-Prot;Acc:P34522])

HSP 1 Score: 194.512 bits (493), Expect = 6.579e-55
Identity = 94/162 (58.02%), Postives = 116/162 (71.60%), Query Frame = 3

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G      LTP+HLRKAKLMF YTRYPNS +LKSYFPDI F K NTAQLVKWFSNFREFYYN+MEK  ++A++ GI    DI V+ +SELFK L TH+N+   I  P   +  VQ TLREF +AI  GK++  SWKK IYK I +L+  +P+FFK+ N++  L
Sbjct:  431 GGGSSSMLTPMHLRKAKLMFFYTRYPNSNLLKSYFPDIRFNKNNTAQLVKWFSNFREFYYNQMEKFARQALAEGITDRNDIFVSKDSELFKVLNTHYNRNNHIKAPDRLVFVVQETLREFHDAIKQGKDIEPSWKKTIYKVINRLEDQIPDFFKEPNFLERL 592

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BLAST of PROX-1 vs. Ensembl Fly
Match: pros (gene:FBgn0004595 transcript:FBtr0304606)

HSP 1 Score: 191.43 bits (485), Expect = 7.374e-52
Identity = 89/160 (55.62%), Postives = 115/160 (71.88%), Query Frame = 3

Query:  978 PKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            P   TLTP+HLRKAKLMF + RYP+S +LK YFPDI F K NTAQLVKWFSNFREFYY +MEK  ++AV+ GI+   D+ +  +SEL++ L  H+N+   I VP  F   V+ TLREFF AI  GK+  QSWKK IYK I+++D  +PE+FK  N++ +L
Sbjct: 1375 PTSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQL 1534

[Close]

BLAST of PROX-1 vs. Ensembl Fly
Match: pros (gene:FBgn0004595 transcript:FBtr0304604)

HSP 1 Score: 191.045 bits (484), Expect = 9.111e-52
Identity = 89/160 (55.62%), Postives = 115/160 (71.88%), Query Frame = 3

Query:  978 PKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            P   TLTP+HLRKAKLMF + RYP+S +LK YFPDI F K NTAQLVKWFSNFREFYY +MEK  ++AV+ GI+   D+ +  +SEL++ L  H+N+   I VP  F   V+ TLREFF AI  GK+  QSWKK IYK I+++D  +PE+FK  N++ +L
Sbjct: 1675 PTSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQL 1834

[Close]

BLAST of PROX-1 vs. Ensembl Fly
Match: pros (gene:FBgn0004595 transcript:FBtr0304603)

HSP 1 Score: 190.66 bits (483), Expect = 1.194e-51
Identity = 89/160 (55.62%), Postives = 115/160 (71.88%), Query Frame = 3

Query:  978 PKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            P   TLTP+HLRKAKLMF + RYP+S +LK YFPDI F K NTAQLVKWFSNFREFYY +MEK  ++AV+ GI+   D+ +  +SEL++ L  H+N+   I VP  F   V+ TLREFF AI  GK+  QSWKK IYK I+++D  +PE+FK  N++ +L
Sbjct: 1514 PTSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQL 1673

[Close]

BLAST of PROX-1 vs. Ensembl Fly
Match: pros (gene:FBgn0004595 transcript:FBtr0304607)

HSP 1 Score: 190.274 bits (482), Expect = 1.333e-51
Identity = 89/160 (55.62%), Postives = 115/160 (71.88%), Query Frame = 3

Query:  978 PKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            P   TLTP+HLRKAKLMF + RYP+S +LK YFPDI F K NTAQLVKWFSNFREFYY +MEK  ++AV+ GI+   D+ +  +SEL++ L  H+N+   I VP  F   V+ TLREFF AI  GK+  QSWKK IYK I+++D  +PE+FK  N++ +L
Sbjct: 1214 PTSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQL 1373

[Close]

BLAST of PROX-1 vs. Ensembl Fly
Match: pros (gene:FBgn0004595 transcript:FBtr0304608)

HSP 1 Score: 188.734 bits (478), Expect = 5.292e-51
Identity = 88/156 (56.41%), Postives = 114/156 (73.08%), Query Frame = 3

Query:  990 TLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            TLTP+HLRKAKLMF + RYP+S +LK YFPDI F K NTAQLVKWFSNFREFYY +MEK  ++AV+ GI+   D+ +  +SEL++ L  H+N+   I VP  F   V+ TLREFF AI  GK+  QSWKK IYK I+++D  +PE+FK  N++ +L
Sbjct: 1547 TLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQL 1702

[Close]

BLAST of PROX-1 vs. Ensembl Zebrafish
Match: prox1a (prospero homeobox 1a [Source:ZFIN;Acc:ZDB-GENE-980526-397])

HSP 1 Score: 181.415 bits (459), Expect = 4.133e-49
Identity = 84/155 (54.19%), Postives = 111/155 (71.61%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            L+P HL+KAKLMF YTRYP+S MLK +F D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+  ++++ V+ + ELF+ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  582 LSPNHLKKAKLMFFYTRYPSSNMLKMFFSDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAINDGVTGSEELSVSRDCELFRALNMHYNKANDFEVPERFLEVAQITLREFFNAIVAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 736

[Close]

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            L+P HL+KAKLMF YTRYP+S MLK +F D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+  ++++ V+ + ELF+ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  582 LSPNHLKKAKLMFFYTRYPSSNMLKMFFSDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAINDGVTGSEELSVSRDCELFRALNMHYNKANDFEVPERFLEVAQITLREFFNAIVAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 736

[Close]

BLAST of PROX-1 vs. Ensembl Zebrafish
Match: prox2 (prospero homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-081003-3])

HSP 1 Score: 176.792 bits (447), Expect = 2.771e-48
Identity = 82/154 (53.25%), Postives = 111/154 (72.08%), Query Frame = 3

Query:  987 YTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWM 1448
            ++LTP HL+KAKLMF YTRYP+S +LK++FPD+ F +  T+QL+KWFSNFREFYY +MEK  ++A+ +G+   KDI V+ ESELF+ L  H+NK     VP  FL   ++TL+EF+ AIS  K+   SWKK IYK I KLD  +PE FK  +++
Sbjct:  430 HSLTPNHLKKAKLMFFYTRYPSSNLLKNFFPDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAIIDGVTDVKDISVSRESELFRALNMHYNKANDFQVPDRFLEVAEVTLQEFYSAISLSKDSDPSWKKAIYKVICKLDSDVPEEFKSPSYL 583

[Close]

BLAST of PROX-1 vs. Ensembl Zebrafish
Match: prox2 (prospero homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-081003-3])

HSP 1 Score: 175.637 bits (444), Expect = 9.108e-48
Identity = 82/152 (53.95%), Postives = 109/152 (71.71%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWM 1448
            LTP HL+KAKLMF YTRYP+S +LK++FPD+ F +  T+QL+KWFSNFREFYY +MEK  ++A+ +G+   KDI V+ ESELF+ L  H+NK     VP  FL   ++TL+EF+ AIS  K+   SWKK IYK I KLD  +PE FK  +++
Sbjct:  431 LTPNHLKKAKLMFFYTRYPSSNLLKNFFPDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAIIDGVTDVKDISVSRESELFRALNMHYNKANDFQVPDRFLEVAEVTLQEFYSAISLSKDSDPSWKKAIYKVICKLDSDVPEEFKSPSYL 582

[Close]

BLAST of PROX-1 vs. Ensembl Zebrafish
Match: prox3 (prospero homeobox 3 [Source:ZFIN;Acc:ZDB-GENE-050107-3])

HSP 1 Score: 150.214 bits (378), Expect = 1.604e-38
Identity = 69/149 (46.31%), Postives = 101/149 (67.79%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKD--IDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFK 1433
            L+P HL+KAKLMF YTRYP+S  LK+YFPD+ F +  T+QL+KWFSNFREF+Y +ME+  ++A    +  A++  + +  ++EL++ L  H+NK     VP  F+   ++ LREFF AI +G++    WKK IYK I KLD  +P+ F+
Sbjct:  494 LSPCHLKKAKLMFFYTRYPSSSTLKTYFPDVKFNRCVTSQLIKWFSNFREFFYIQMERFARQAAREVLTSARERALRLGRDTELYRILNMHYNKSNDYQVPERFVEISEVALREFFTAIQSGRDADPCWKKSIYKIICKLDSPVPDSFR 642

[Close]

BLAST of PROX-1 vs. Ensembl Xenopus
Match: PROX1 (prospero homeobox 1 [Source:NCBI gene;Acc:100134995])

HSP 1 Score: 178.333 bits (451), Expect = 6.431e-48
Identity = 82/155 (52.90%), Postives = 111/155 (71.61%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            L+P HL+KAKLMF YTRYP+S MLK++F D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++GI   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +P+ F+  N + EL
Sbjct:  582 LSPNHLKKAKLMFFYTRYPSSNMLKTFFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGITSTEELCITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPDIFRSPNCLQEL 736

[Close]

BLAST of PROX-1 vs. Ensembl Mouse
Match: Prox1 (prospero homeobox 1 [Source:MGI Symbol;Acc:MGI:97772])

HSP 1 Score: 184.111 bits (466), Expect = 4.656e-50
Identity = 85/162 (52.47%), Postives = 113/162 (69.75%), Query Frame = 3

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  573 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 734

[Close]

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  573 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 734

[Close]

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  573 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 734

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BLAST of PROX-1 vs. Ensembl Mouse
Match: Prox2 (prospero homeobox 2 [Source:MGI Symbol;Acc:MGI:1920672])

HSP 1 Score: 175.637 bits (444), Expect = 1.095e-47
Identity = 82/155 (52.90%), Postives = 112/155 (72.26%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            L+P HL+KAKLMF +TRYP+S +LK+YFPD+ F +  T+Q++KWFSNFREFYY +MEK  ++A+S+GI  A+ + V  +SELF+ L TH+NK     VP  FL    +TL+EFF A+ AGK+   SWKKPIYK I+KLD  +PE  K  +++  L
Sbjct:  436 LSPGHLKKAKLMFFFTRYPSSSLLKAYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKYARQALSDGITNAQALAVLRDSELFRVLNTHYNKGNDFEVPDCFLEIAALTLKEFFRAVLAGKDSDPSWKKPIYKVISKLDSDVPEMLKSPSFLPGL 590

[Close]

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            L+P HL+KAKLMF +TRYP+S +LK+YFPD+ F +  T+Q++KWFSNFREFYY +MEK  ++A+S+GI  A+ + V  +SELF+ L TH+NK     VP  FL    +TL+EFF A+ AGK+   SWKKPIYK I+KLD  +PE  K  +++  L
Sbjct:  436 LSPGHLKKAKLMFFFTRYPSSSLLKAYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKYARQALSDGITNAQALAVLRDSELFRVLNTHYNKGNDFEVPDCFLEIAALTLKEFFRAVLAGKDSDPSWKKPIYKVISKLDSDVPEMLKSPSFLPGL 590

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BLAST of PROX-1 vs. UniProt/SwissProt
Match: sp|P34522|PROS1_CAEEL (Homeobox protein prospero homolog 1 OS=Caenorhabditis elegans OX=6239 GN=pros-1 PE=2 SV=2)

HSP 1 Score: 194.512 bits (493), Expect = 8.369e-54
Identity = 94/162 (58.02%), Postives = 116/162 (71.60%), Query Frame = 3

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G      LTP+HLRKAKLMF YTRYPNS +LKSYFPDI F K NTAQLVKWFSNFREFYYN+MEK  ++A++ GI    DI V+ +SELFK L TH+N+   I  P   +  VQ TLREF +AI  GK++  SWKK IYK I +L+  +P+FFK+ N++  L
Sbjct:  431 GGGSSSMLTPMHLRKAKLMFFYTRYPNSNLLKSYFPDIRFNKNNTAQLVKWFSNFREFYYNQMEKFARQALAEGITDRNDIFVSKDSELFKVLNTHYNRNNHIKAPDRLVFVVQETLREFHDAIKQGKDIEPSWKKTIYKVINRLEDQIPDFFKEPNFLERL 592

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BLAST of PROX-1 vs. UniProt/SwissProt
Match: sp|P29617|PROS_DROME (Homeobox protein prospero OS=Drosophila melanogaster OX=7227 GN=pros PE=1 SV=3)

HSP 1 Score: 188.734 bits (478), Expect = 5.305e-50
Identity = 88/156 (56.41%), Postives = 114/156 (73.08%), Query Frame = 3

Query:  990 TLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            TLTP+HLRKAKLMF + RYP+S +LK YFPDI F K NTAQLVKWFSNFREFYY +MEK  ++AV+ GI+   D+ +  +SEL++ L  H+N+   I VP  F   V+ TLREFF AI  GK+  QSWKK IYK I+++D  +PE+FK  N++ +L
Sbjct: 1547 TLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFREFYYIQMEKYARQAVTEGIKTPDDLLIAGDSELYRVLNLHYNRNNHIEVPQNFRFVVESTLREFFRAIQGGKDTEQSWKKSIYKIISRMDDPVPEYFKSPNFLEQL 1702

[Close]

BLAST of PROX-1 vs. UniProt/SwissProt
Match: sp|P48437|PROX1_MOUSE (Prospero homeobox protein 1 OS=Mus musculus OX=10090 GN=Prox1 PE=1 SV=2)

HSP 1 Score: 184.111 bits (466), Expect = 3.257e-49
Identity = 85/162 (52.47%), Postives = 113/162 (69.75%), Query Frame = 3

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  573 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 734

[Close]

BLAST of PROX-1 vs. UniProt/SwissProt
Match: sp|Q92786|PROX1_HUMAN (Prospero homeobox protein 1 OS=Homo sapiens OX=9606 GN=PROX1 PE=1 SV=2)

HSP 1 Score: 184.111 bits (466), Expect = 3.257e-49
Identity = 85/162 (52.47%), Postives = 113/162 (69.75%), Query Frame = 3

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  573 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 734

[Close]

BLAST of PROX-1 vs. UniProt/SwissProt
Match: sp|Q91018|PROX1_CHICK (Prospero homeobox protein 1 OS=Gallus gallus OX=9031 GN=PROX1 PE=2 SV=1)

HSP 1 Score: 184.111 bits (466), Expect = 3.630e-49
Identity = 85/162 (52.47%), Postives = 113/162 (69.75%), Query Frame = 3

Query:  972 GDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            G   +  L+P HL+KAKLMF YTRYP+S MLK+YF D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+   +++ +T + EL++ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  572 GSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 733

[Close]

BLAST of PROX-1 vs. TrEMBL
Match: H9CXU6 (PROX-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 870.922 bits (2249), Expect = 0.000e+0
Identity = 480/480 (100.00%), Postives = 480/480 (100.00%), Query Frame = 3

Query:   48 MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKRLRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKLNNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMXXXXXXXXXXXXXXXXTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQLFHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILXXXXXXXXXXXXXXXXXLPRRNTSLGNFPNLHESTIPETTRFXXXXXXXXXXXXXXXXEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLNS 1487
            MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKRLRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKLNNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMLNQFQKFLFNKNFHNQTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQLFHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILKSSSNRKRKRTKVTDTRLPRRNTSLGNFPNLHESTIPETTRFSNYLNPPSNSSQSSHSEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLNS
Sbjct:    1 MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKRLRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKLNNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMLNQFQKFLFNKNFHNQTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQLFHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILKSSSNRKRKRTKVTDTRLPRRNTSLGNFPNLHESTIPETTRFSNYLNPPSNSSQSSHSEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLNS 480

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BLAST of PROX-1 vs. TrEMBL
Match: A0A183AEI2 (Prospero domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS5367 PE=4 SV=1)

HSP 1 Score: 217.624 bits (553), Expect = 9.678e-65
Identity = 102/162 (62.96%), Postives = 128/162 (79.01%), Query Frame = 3

Query:  978 PKRY-TLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELA 1460
            PKRY TLTP+HLRKAKLMF YTRYPNS ++K YFPD+ FYK NTAQLVKWFSNFREFYY +MEK  + A+S G++ A++I VT +SEL++ L  H+N+ +Q+ VP  F   V+ TLREFF A+  GK+  QSWKKPIYK IA++DQ +PEFFK+ NWM +LA
Sbjct:    7 PKRYYTLTPVHLRKAKLMFFYTRYPNSTLIKMYFPDVKFYKNNTAQLVKWFSNFREFYYIQMEKFARVAISEGVRSAEEIHVTTDSELYRALNLHYNRNQQLEVPEHFRIVVEATLREFFNALMTGKDAEQSWKKPIYKIIARMDQPVPEFFKNPNWMEQLA 168

[Close]

BLAST of PROX-1 vs. TrEMBL
Match: A0A1S8WHF4 (Prospero domain-containing protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=X801_10339 PE=4 SV=1)

HSP 1 Score: 213.772 bits (543), Expect = 4.448e-63
Identity = 98/157 (62.42%), Postives = 123/157 (78.34%), Query Frame = 3

Query:  990 TLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELA 1460
            TLTP+HLRKAKLMF YTRYPNS ++K YFPD+ FYK NTAQLVKWFSNFREFYY +MEK  + A+S G++ A +I VT +SEL++ L  H+N+ +Q+ VP  F   V+ TLREFF A+  GK+  QSWKKPIYK IA++DQ +PEFFK+ NWM +LA
Sbjct:   32 TLTPVHLRKAKLMFFYTRYPNSTLIKMYFPDVKFYKNNTAQLVKWFSNFREFYYIQMEKFARVAISEGVRSADEIHVTTDSELYRALNLHYNRNQQLEVPDHFRIVVEATLREFFNALMTGKDTEQSWKKPIYKIIARMDQPVPEFFKNPNWMEQLA 188

[Close]

BLAST of PROX-1 vs. TrEMBL
Match: A0A074ZP01 (Prospero domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_07444 PE=4 SV=1)

HSP 1 Score: 213.772 bits (543), Expect = 5.580e-63
Identity = 98/157 (62.42%), Postives = 123/157 (78.34%), Query Frame = 3

Query:  990 TLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELA 1460
            TLTP+HLRKAKLMF YTRYPNS ++K YFPD+ FYK NTAQLVKWFSNFREFYY +MEK  + A+S G++ A +I VT +SEL++ L  H+N+ +Q+ VP  F   V+ TLREFF A+  GK+  QSWKKPIYK IA++DQ +PEFFK+ NWM +LA
Sbjct:   37 TLTPVHLRKAKLMFFYTRYPNSTLIKMYFPDVKFYKNNTAQLVKWFSNFREFYYIQMEKFARVAISEGVRSADEIHVTTDSELYRALNLHYNRNQQLEVPDHFRIVVEATLREFFNALMTGKDTEQSWKKPIYKIIARMDQPVPEFFKNPNWMEQLA 193

[Close]

BLAST of PROX-1 vs. TrEMBL
Match: A0A4S2KFM3 (Prospero domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_010997 PE=4 SV=1)

HSP 1 Score: 218.779 bits (556), Expect = 3.226e-58
Identity = 98/157 (62.42%), Postives = 124/157 (78.98%), Query Frame = 3

Query:  990 TLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELA 1460
            TLTP+HLRKAKLMF YTRYPNS ++K YFPD+ FYK NTAQLVKWFSNFREFYY +MEK  + A+S G++ A +I VT +SEL++ L  H+N+ +Q+ VP  F   V+ TLREFF+A+  GK+  QSWKKPIYK IA++DQ +PEFFK+ NWM +LA
Sbjct:  817 TLTPVHLRKAKLMFFYTRYPNSTLIKMYFPDVKFYKNNTAQLVKWFSNFREFYYIQMEKFARVAISEGVRTADEIHVTTDSELYRALNLHYNRNQQLEVPDHFRIVVEATLREFFKALMTGKDTEQSWKKPIYKIIARMDQPVPEFFKNPNWMEQLA 973

[Close]

BLAST of PROX-1 vs. Ensembl Cavefish
Match: ENSAMXT00000012572.2 (prospero homeobox protein 1-like [Source:NCBI gene;Acc:103022569])

HSP 1 Score: 185.267 bits (469), Expect = 2.083e-50
Identity = 87/155 (56.13%), Postives = 111/155 (71.61%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            L+P HL+KAKLMF YTRYP+S MLK +F D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+  A +I V+ +SELF+ L  H+NK     VP  FL   QITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  627 LSPNHLKKAKLMFFYTRYPSSNMLKMFFSDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAINDGVTGADEISVSRDSELFRALNMHYNKANDFEVPERFLEVAQITLREFFNAIVAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 781

[Close]

BLAST of PROX-1 vs. Ensembl Cavefish
Match: prox1a (prospero homeobox protein 1 [Source:NCBI gene;Acc:103040734])

HSP 1 Score: 177.948 bits (450), Expect = 5.989e-48
Identity = 82/155 (52.90%), Postives = 111/155 (71.61%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            L+P HL+KAKLMF YTRYP+S MLK +F D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+  ++++ V+ + EL++ L  H+NK     VP  FL   QITL+EFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  583 LSPNHLKKAKLMFFYTRYPSSNMLKMFFSDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAINDGVAGSEELTVSRDCELYRALNMHYNKANDFEVPERFLEVAQITLQEFFNAIVAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 737

[Close]

BLAST of PROX-1 vs. Ensembl Cavefish
Match: prox2 (prospero homeobox 2 [Source:NCBI gene;Acc:103029539])

HSP 1 Score: 174.096 bits (440), Expect = 7.534e-47
Identity = 82/152 (53.95%), Postives = 108/152 (71.05%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWM 1448
            LTP HL+KAKLMF YTRYP+S +LK++FPD+ F +  T+QL+KWFSNFREFYY +MEK  ++A+ +G+   KD+ VT +SELF+ L  H+NK     VP  FL   +ITL EF+ AIS  K+   SWKK IYK I KLD  +PE FK  +++
Sbjct:  516 LTPNHLKKAKLMFFYTRYPSSNVLKTFFPDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAIVDGVSDVKDMAVTRDSELFRALNMHYNKANDFQVPDRFLEVAEITLHEFYNAISLNKDSDPSWKKAIYKVICKLDSDVPEEFKSPSYL 667

[Close]

BLAST of PROX-1 vs. Ensembl Cavefish
Match: prox3 (prospero homeobox protein 1-like [Source:NCBI gene;Acc:103040122])

HSP 1 Score: 156.377 bits (394), Expect = 1.642e-40
Identity = 72/149 (48.32%), Postives = 101/149 (67.79%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKD--IDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFK 1433
            L+P HL+KAKLMF YTRYP+S  LK+YFPD+ F +  T+QL+KWFSNFREF+Y +ME+  ++A   G+  ++D  + ++  SELF+ L  H+NK     VP  F+   ++ LREFF AI  G++    WKK IYK I KLD  +P+ F+
Sbjct:  545 LSPCHLKKAKLMFFYTRYPSSNTLKTYFPDVKFNRCVTSQLIKWFSNFREFFYIQMERFARQAAREGLPTSRDRVLRLSRNSELFRILNMHYNKSNDYQVPDRFVEVSELALREFFAAIQGGRDTDPCWKKSIYKIICKLDSPVPDSFR 693

[Close]

BLAST of PROX-1 vs. Ensembl Cavefish
Match: prox3 (prospero homeobox protein 1-like [Source:NCBI gene;Acc:103040122])

HSP 1 Score: 155.992 bits (393), Expect = 1.744e-40
Identity = 72/149 (48.32%), Postives = 101/149 (67.79%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKD--IDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFK 1433
            L+P HL+KAKLMF YTRYP+S  LK+YFPD+ F +  T+QL+KWFSNFREF+Y +ME+  ++A   G+  ++D  + ++  SELF+ L  H+NK     VP  F+   ++ LREFF AI  G++    WKK IYK I KLD  +P+ F+
Sbjct:  519 LSPCHLKKAKLMFFYTRYPSSNTLKTYFPDVKFNRCVTSQLIKWFSNFREFFYIQMERFARQAAREGLPTSRDRVLRLSRNSELFRILNMHYNKSNDYQVPDRFVEVSELALREFFAAIQGGRDTDPCWKKSIYKIICKLDSPVPDSFR 667

[Close]

BLAST of PROX-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007312.1 (pep scaffold:Pmarinus_7.0:GL481361:690:12474:1 gene:ENSPMAG00000006606.1 transcript:ENSPMAT00000007312.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 120.168 bits (300), Expect = 5.387e-33
Identity = 54/92 (58.70%), Postives = 73/92 (79.35%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNK 1268
            LTP HL+KAKLMF Y+RYP+S MLK YFPD+ F +  T+QL+KWFSNFREFYY +MEK  + A+++G+  A+++ VT +SELF+ L  H+NK
Sbjct:    4 LTPGHLKKAKLMFYYSRYPSSTMLKIYFPDVKFNRCITSQLIKWFSNFREFYYIQMEKFARAALADGVTSAEELTVTRDSELFRALNVHYNK 95

[Close]

BLAST of PROX-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007316.1 (pep scaffold:Pmarinus_7.0:GL481361:12253:13226:1 gene:ENSPMAG00000006606.1 transcript:ENSPMAT00000007316.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 72.4034 bits (176), Expect = 1.139e-15
Identity = 30/55 (54.55%), Postives = 44/55 (80.00%), Query Frame = 3

Query: 1104 TAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNK 1268
            T+QL+KWFSNFREFYY +MEK  + A+++G+  A+++ VT +SELF+ L  H+NK
Sbjct:   10 TSQLIKWFSNFREFYYIQMEKFARAALADGVTSAEELTVTRDSELFRALNVHYNK 64

[Close]

BLAST of PROX-1 vs. Ensembl Medaka
Match: prox1 (prospero homeobox 1 [Source:NCBI gene;Acc:100302041])

HSP 1 Score: 186.808 bits (473), Expect = 9.048e-51
Identity = 86/161 (53.42%), Postives = 115/161 (71.43%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDEND 1475
            L+P HL+KAKLMF YTRYP+S MLK +F D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+  A+++ V+ + ELF+ L  H+NK     VP  FL   +ITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL  D++D
Sbjct:  663 LSPNHLKKAKLMFFYTRYPSSNMLKMFFSDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAINDGVTGAEELSVSRDCELFRALNMHYNKANDFEVPDRFLEVAEITLREFFNAIVAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHDDSD 823

[Close]

BLAST of PROX-1 vs. Ensembl Medaka
Match: prox2 (prospero homeobox 2 [Source:NCBI gene;Acc:101167581])

HSP 1 Score: 182.185 bits (461), Expect = 5.236e-50
Identity = 85/152 (55.92%), Postives = 110/152 (72.37%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWM 1448
            LTP HL+KAKLMF YTRYP+S +LK+YFPD+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++GI+  KDI V+ +SELF+ L  H+NK     VP  FL   +ITL EF+ AISA K+   SWKK IYK I K+D  +PE FK  + M
Sbjct:  477 LTPSHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAIADGIRDVKDITVSRDSELFRALNMHYNKANDFHVPDRFLEVAEITLHEFYNAISASKDSDSSWKKSIYKVICKMDSEVPEEFKTSSCM 628

[Close]

BLAST of PROX-1 vs. Ensembl Medaka
Match: prox1b (prospero-related homeobox protein 1b [Source:NCBI gene;Acc:100302040])

HSP 1 Score: 184.882 bits (468), Expect = 5.478e-50
Identity = 85/158 (53.80%), Postives = 112/158 (70.89%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKD 1466
            L+P HL+KAKLMF YTRYP+S MLK +F D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+  A+++ V  ++ELF+ L  H+NK     VP  FL   Q+TLREFF AI AGK+   SWKK IYK I KLD  +PE FK  N + EL +D
Sbjct:  725 LSPNHLKKAKLMFFYTRYPSSNMLKMFFSDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAINDGVTGAEELTVGRDAELFRALNMHYNKANDFEVPDRFLEVAQVTLREFFNAIVAGKDADPSWKKAIYKVICKLDSEVPEVFKSPNCLQELLRD 882

[Close]

BLAST of PROX-1 vs. Ensembl Medaka
Match: prox2 (prospero homeobox 2 [Source:NCBI gene;Acc:101167581])

HSP 1 Score: 182.185 bits (461), Expect = 8.183e-50
Identity = 85/152 (55.92%), Postives = 110/152 (72.37%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWM 1448
            LTP HL+KAKLMF YTRYP+S +LK+YFPD+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++GI+  KDI V+ +SELF+ L  H+NK     VP  FL   +ITL EF+ AISA K+   SWKK IYK I K+D  +PE FK  + M
Sbjct:  506 LTPSHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAIADGIRDVKDITVSRDSELFRALNMHYNKANDFHVPDRFLEVAEITLHEFYNAISASKDSDSSWKKSIYKVICKMDSEVPEEFKTSSCM 657

[Close]

BLAST of PROX-1 vs. Ensembl Medaka
Match: prox1 (prospero homeobox 1 [Source:NCBI gene;Acc:100302041])

HSP 1 Score: 182.57 bits (462), Expect = 2.984e-49
Identity = 84/155 (54.19%), Postives = 111/155 (71.61%), Query Frame = 3

Query:  993 LTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMEL 1457
            L+P HL+KAKLMF YTRYP+S MLK +F D+ F +  T+QL+KWFSNFREFYY +MEK  ++A+++G+  A+++ V+ + ELF+ L  H+NK     VP  FL   +ITLREFF AI AGK++  SWKK IYK I KLD  +PE FK  N + EL
Sbjct:  663 LSPNHLKKAKLMFFYTRYPSSNMLKMFFSDVKFNRCITSQLIKWFSNFREFYYIQMEKFARQAINDGVTGAEELSVSRDCELFRALNMHYNKANDFEVPDRFLEVAEITLREFFNAIVAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQEL 817

[Close]

BLAST of PROX-1 vs. Planmine SMEST
Match: SMESG000068287.1 (SMESG000068287.1)

HSP 1 Score: 873.233 bits (2255), Expect = 0.000e+0
Identity = 479/479 (100.00%), Postives = 479/479 (100.00%), Query Frame = 3

Query:   48 MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKRLRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKLNNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMXXXXXXXXXXXXXXXXTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQLFHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILXXXXXXXXXXXXXXXXXLPRRNTSLGNFPNLHESTIPETTRFXXXXXXXXXXXXXXXXEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLN 1484
            MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKRLRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKLNNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMLNQFQKFLFNKNFHNQTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQLFHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILKSSSNRKRKRTKVTDTRLPRRNTSLGNFPNLHESTIPETTRFSNYLNPPSNSSQSSHSEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLN
Sbjct:    1 MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKRLRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKLNNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMLNQFQKFLFNKNFHNQTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQLFHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILKSSSNRKRKRTKVTDTRLPRRNTSLGNFPNLHESTIPETTRFSNYLNPPSNSSQSSHSEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLN 479

[Close]

BLAST of PROX-1 vs. Planmine SMEST
Match: SMESG000068287.1 (SMESG000068287.1)

HSP 1 Score: 870.922 bits (2249), Expect = 0.000e+0
Identity = 480/480 (100.00%), Postives = 480/480 (100.00%), Query Frame = 3

Query:   48 MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKRLRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKLNNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMXXXXXXXXXXXXXXXXTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQLFHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILXXXXXXXXXXXXXXXXXLPRRNTSLGNFPNLHESTIPETTRFXXXXXXXXXXXXXXXXEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLNS 1487
            MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKRLRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKLNNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMLNQFQKFLFNKNFHNQTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQLFHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILKSSSNRKRKRTKVTDTRLPRRNTSLGNFPNLHESTIPETTRFSNYLNPPSNSSQSSHSEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLNS
Sbjct:    1 MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKRLRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKLNNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMLNQFQKFLFNKNFHNQTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQLFHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILKSSSNRKRKRTKVTDTRLPRRNTSLGNFPNLHESTIPETTRFSNYLNPPSNSSQSSHSEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLNS 480

[Close]

BLAST of PROX-1 vs. Planmine SMEST
Match: SMESG000032751.1 (SMESG000032751.1)

HSP 1 Score: 293.123 bits (749), Expect = 8.164e-94
Identity = 138/176 (78.41%), Postives = 156/176 (88.64%), Query Frame = 3

Query:  960 EETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMMELAKDENDSLNS 1487
            E+   DPK+YTLTPIHLRKAKLMFLYTRYPNSQMLK++FPDI FYKQNTAQLVKWFSNFREFYY+EMEKAVQR++S+GI+ + ++ VT E ELFKNLMTHFNK +QI VP EF+ TVQITLREFFEA S GKNLHQSWKKPIYK IAKLDQ LPEFFKD NWM+ELAK+EN + +S
Sbjct:  270 EDLTNDPKKYTLTPIHLRKAKLMFLYTRYPNSQMLKNFFPDIIFYKQNTAQLVKWFSNFREFYYSEMEKAVQRSISSGIKYSSELFVTEECELFKNLMTHFNKNRQIEVPKEFMITVQITLREFFEAFSVGKNLHQSWKKPIYKNIAKLDQPLPEFFKDFNWMLELAKEENGASHS 445

[Close]

BLAST of PROX-1 vs. Planmine SMEST
Match: SMESG000035419.1 (SMESG000035419.1)

HSP 1 Score: 171.785 bits (434), Expect = 5.021e-49
Identity = 77/156 (49.36%), Postives = 111/156 (71.15%), Query Frame = 3

Query:  990 TLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSN-GIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNWMME 1454
            +LT  HLRKAKLMFLY RYPNS +LK +FPDITF K +TAQLVKWFSNFREF+Y ++EK ++  + N       D+ + ++ E+++ L+ H+++  QI +P  FL  ++ TL  F++AI  G++   SWKKPIYK IA++D  +PEFFK   W+++
Sbjct:  152 SLTSQHLRKAKLMFLYVRYPNSSILKDFFPDITFDKNSTAQLVKWFSNFREFFYIQLEKYIRTNIINLRFTDENDVKIDMDCEIYRTLVNHYDRTNQIQIPTNFLQVLKTTLWHFYQAIVTGRDRDHSWKKPIYKIIARMDITVPEFFKHTQWLLD 307

[Close]

BLAST of PROX-1 vs. Planmine SMEST
Match: SMESG000012837.1 (SMESG000012837.1)

HSP 1 Score: 172.94 bits (437), Expect = 6.798e-49
Identity = 85/152 (55.92%), Postives = 109/152 (71.71%), Query Frame = 3

Query:  990 TLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYKQNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKNLMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTIAKLDQMLPEFFKDMNW 1445
             L P HLRKAKLMF YTRYP+S  LKS FPDI F K NTAQLVKWFSNFREFYY ++EK  ++ +S G +   ++D  +  +L++ L+ H+N+  QI+VP EF   V+ TL EF+ AI +GK+  QSWKK IYK IA+LDQ  P +FK+ NW
Sbjct:  201 VLGPNHLRKAKLMFFYTRYPSSSFLKSQFPDIKFEKSNTAQLVKWFSNFREFYYIQIEKFARQILSEG-KLFGELDKLMHEDLYRILVIHYNRNNQIMVPKEFSLVVKTTLEEFYLAIGSGKDKEQSWKKVIYKKIARLDQDTPSYFKNPNW 351

The following BLAST results are available for this feature:

BLAST of PROX-1 vs. Ensembl Human
BLAST of PROX-1 vs. Ensembl Celegans
BLAST of PROX-1 vs. Ensembl Fly
BLAST of PROX-1 vs. Ensembl Zebrafish
BLAST of PROX-1 vs. Ensembl Xenopus
BLAST of PROX-1 vs. Ensembl Mouse
BLAST of PROX-1 vs. UniProt/SwissProt
BLAST of PROX-1 vs. TrEMBL
BLAST of PROX-1 vs. Ensembl Cavefish
BLAST of PROX-1 vs. Ensembl Sea Lamprey
BLAST of PROX-1 vs. Ensembl Yeast
BLAST of PROX-1 vs. Ensembl Nematostella
BLAST of PROX-1 vs. Ensembl Medaka
BLAST of PROX-1 vs. Planmine SMEST

BLAST of PROX-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PROX1	6.781e-50	52.47	prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9...	[more]
PROX1	6.781e-50	52.47	prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9...	[more]
PROX1	6.781e-50	52.47	prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9...	[more]
PROX1	6.781e-50	52.47	prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9...	[more]
PROX2	4.565e-46	52.98	prospero homeobox 2 [Source:HGNC Symbol;Acc:HGNC:2...	[more]

BLAST of PROX-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
pros-1	6.579e-55	58.02	Homeobox protein prospero homolog 1 [Source:UniPr...	[more]

BLAST of PROX-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pros	7.374e-52	55.63	gene:FBgn0004595 transcript:FBtr0304606	[more]
pros	9.111e-52	55.63	gene:FBgn0004595 transcript:FBtr0304604	[more]
pros	1.194e-51	55.63	gene:FBgn0004595 transcript:FBtr0304603	[more]
pros	1.333e-51	55.63	gene:FBgn0004595 transcript:FBtr0304607	[more]
pros	5.292e-51	56.41	gene:FBgn0004595 transcript:FBtr0304608	[more]

BLAST of PROX-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prox1a	4.133e-49	54.19	prospero homeobox 1a [Source:ZFIN;Acc:ZDB-GENE-980...	[more]
prox1a	4.133e-49	54.19	prospero homeobox 1a [Source:ZFIN;Acc:ZDB-GENE-980...	[more]
prox2	2.771e-48	53.25	prospero homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-0810...	[more]
prox2	9.108e-48	53.95	prospero homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-0810...	[more]
prox3	1.604e-38	46.31	prospero homeobox 3 [Source:ZFIN;Acc:ZDB-GENE-0501...	[more]

BLAST of PROX-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
PROX1	6.431e-48	52.90	prospero homeobox 1 [Source:NCBI gene;Acc:10013499...	[more]

BLAST of PROX-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Prox1	4.656e-50	52.47	prospero homeobox 1 [Source:MGI Symbol;Acc:MGI:977...	[more]
Prox1	4.656e-50	52.47	prospero homeobox 1 [Source:MGI Symbol;Acc:MGI:977...	[more]
Prox1	4.656e-50	52.47	prospero homeobox 1 [Source:MGI Symbol;Acc:MGI:977...	[more]
Prox2	1.095e-47	52.90	prospero homeobox 2 [Source:MGI Symbol;Acc:MGI:192...	[more]
Prox2	1.095e-47	52.90	prospero homeobox 2 [Source:MGI Symbol;Acc:MGI:192...	[more]

BLAST of PROX-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P34522\|PROS1_CAEEL	8.369e-54	58.02	Homeobox protein prospero homolog 1 OS=Caenorhabdi...	[more]
sp\|P29617\|PROS_DROME	5.305e-50	56.41	Homeobox protein prospero OS=Drosophila melanogast...	[more]
sp\|P48437\|PROX1_MOUSE	3.257e-49	52.47	Prospero homeobox protein 1 OS=Mus musculus OX=100...	[more]
sp\|Q92786\|PROX1_HUMAN	3.257e-49	52.47	Prospero homeobox protein 1 OS=Homo sapiens OX=960...	[more]
sp\|Q91018\|PROX1_CHICK	3.630e-49	52.47	Prospero homeobox protein 1 OS=Gallus gallus OX=90...	[more]

BLAST of PROX-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
H9CXU6	0.000e+0	100.00	PROX-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=...	[more]
A0A183AEI2	9.678e-65	62.96	Prospero domain-containing protein OS=Echinostoma ...	[more]
A0A1S8WHF4	4.448e-63	62.42	Prospero domain-containing protein (Fragment) OS=O...	[more]
A0A074ZP01	5.580e-63	62.42	Prospero domain-containing protein OS=Opisthorchis...	[more]
A0A4S2KFM3	3.226e-58	62.42	Prospero domain-containing protein OS=Opisthorchis...	[more]

BLAST of PROX-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000012572.2	2.083e-50	56.13	prospero homeobox protein 1-like [Source:NCBI gene...	[more]
prox1a	5.989e-48	52.90	prospero homeobox protein 1 [Source:NCBI gene;Acc:...	[more]
prox2	7.534e-47	53.95	prospero homeobox 2 [Source:NCBI gene;Acc:10302953...	[more]
prox3	1.642e-40	48.32	prospero homeobox protein 1-like [Source:NCBI gene...	[more]
prox3	1.744e-40	48.32	prospero homeobox protein 1-like [Source:NCBI gene...	[more]

BLAST of PROX-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000007312.1	5.387e-33	58.70	pep scaffold:Pmarinus_7.0:GL481361:690:12474:1 gen...	[more]
ENSPMAT00000007316.1	1.139e-15	54.55	pep scaffold:Pmarinus_7.0:GL481361:12253:13226:1 g...	[more]

BLAST of PROX-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of PROX-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of PROX-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prox1	9.048e-51	53.42	prospero homeobox 1 [Source:NCBI gene;Acc:10030204...	[more]
prox2	5.236e-50	55.92	prospero homeobox 2 [Source:NCBI gene;Acc:10116758...	[more]
prox1b	5.478e-50	53.80	prospero-related homeobox protein 1b [Source:NCBI ...	[more]
prox2	8.183e-50	55.92	prospero homeobox 2 [Source:NCBI gene;Acc:10116758...	[more]
prox1	2.984e-49	54.19	prospero homeobox 1 [Source:NCBI gene;Acc:10030204...	[more]

BLAST of PROX-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000068287.1	0.000e+0	100.00	SMESG000068287.1	[more]
SMESG000068287.1	0.000e+0	100.00	SMESG000068287.1	[more]
SMESG000032751.1	8.164e-94	78.41	SMESG000032751.1	[more]
SMESG000035419.1	5.021e-49	49.36	SMESG000035419.1	[more]
SMESG000012837.1	6.798e-49	55.92	SMESG000012837.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30016901
GenBank	AFD29617.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30016901 ID=SMED30016901|Name=PROX-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1564bp
AAATAATAGAAAAAAACTTTCCGTTGATATTAAATTTATAATAGTTCATG
ATAAAGTCAGCCGGAATAGCAACGTCCTCAATGTGCTGTAAAGTGCAGAA
TCCAAAAATGAATTCACCACAACCATATTCAGTTCAGTCTTTGCTAAATC
AAGAAGGCGATGATTCAATTCTTGATTTGTCAGTTAAAGAAAAAAGATTA
AGACAAACCCATGAAGAACCTGTATCTAATGAAATGATGAACCTATCAGA
AGTTCTACCCGAGCTCTCAAATCCCGATCGCATGAAACAAATACTTTTCA
ACGTGATACAACAAAGAGAACTTCACGCTCAATCAAATAAAAAACTCAAT
AATCAAAATGTTGATTTTTTTCAGACATCTCAGTCAAATTTAGACAACCT
TCAGAAATTTTGCAACCCTTCCCAAAACCTTCCATGGAATTTTTTACGAC
CCCCCGTTTCCAGTGTTTCAGATACAGGAGCAAGCATGCTCAACCAATTC
CAGAAATTCCTATTCAATAAAAACTTTCATAATCAAACAATAACAAATCC
CAATTCGATTTATCCTCGACGAAATATGAAAAACCTTTTTCCAAATTCAT
TTAATCCCGATTCAATTCCCCATTATTTCAATAACTTAACTCAACTCTTT
CATTCGAGACTGAATCAAAATAATCAAACAGAAACGACATCACACATTCC
AGTAGTCTTACCAGAAAACTTTTCGAAACAATATACTAATTCAAACATAG
ATATTAACACTCATTTCAGTTTACAAAACATTCTCAAATCTTCGTCGAAT
AGGAAAAGAAAACGAACAAAAGTTACTGATACACGTCTTCCAAGACGAAA
TACAAGTTTAGGTAACTTCCCGAATCTCCACGAATCGACAATACCAGAAA
CAACACGGTTTTCCAATTACCTAAATCCTCCATCAAACAGTTCCCAGTCA
TCACATTCGGAAGAAACACCCGGTGATCCAAAAAGATATACGCTAACACC
GATTCATTTACGAAAGGCCAAACTTATGTTCCTCTATACCCGATATCCGA
ACTCACAAATGCTTAAGAGCTATTTTCCTGATATCACGTTCTACAAACAG
AACACTGCTCAACTAGTAAAATGGTTCAGTAACTTCCGAGAATTTTATTA
CAATGAAATGGAGAAAGCCGTTCAACGAGCCGTTTCAAATGGTATACAGC
AAGCCAAAGACATCGATGTGACGGTCGAATCCGAGTTATTCAAAAATTTA
ATGACCCATTTCAATAAGAAAAAACAAATCGTTGTACCATGTGAATTTTT
AACAACCGTTCAAATTACATTGCGAGAATTTTTCGAAGCGATTTCCGCCG
GTAAAAACCTTCATCAATCTTGGAAGAAACCGATTTATAAAACTATTGCT
AAACTCGATCAGATGTTGCCAGAGTTTTTTAAGGATATGAACTGGATGAT
GGAGCTGGCCAAAGATGAGAATGACAGTTTAAATAGTTAATACGTTACTG
AAAATTGTTTGAATTATACACACGTATAGAGACTATAATAAAAATGATAT
GGATAAAAATAAAA

protein sequence of SMED30016901-orf-1

>SMED30016901-orf-1 ID=SMED30016901-orf-1|Name=SMED30016901-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=481bp
MIKSAGIATSSMCCKVQNPKMNSPQPYSVQSLLNQEGDDSILDLSVKEKR
LRQTHEEPVSNEMMNLSEVLPELSNPDRMKQILFNVIQQRELHAQSNKKL
NNQNVDFFQTSQSNLDNLQKFCNPSQNLPWNFLRPPVSSVSDTGASMLNQ
FQKFLFNKNFHNQTITNPNSIYPRRNMKNLFPNSFNPDSIPHYFNNLTQL
FHSRLNQNNQTETTSHIPVVLPENFSKQYTNSNIDINTHFSLQNILKSSS
NRKRKRTKVTDTRLPRRNTSLGNFPNLHESTIPETTRFSNYLNPPSNSSQ
SSHSEETPGDPKRYTLTPIHLRKAKLMFLYTRYPNSQMLKSYFPDITFYK
QNTAQLVKWFSNFREFYYNEMEKAVQRAVSNGIQQAKDIDVTVESELFKN
LMTHFNKKKQIVVPCEFLTTVQITLREFFEAISAGKNLHQSWKKPIYKTI
AKLDQMLPEFFKDMNWMMELAKDENDSLNS*

Aliases

The feature 'PROX-1' has the following synonyms


Synonym
PROX-1

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000039	gamma neoblast
PLANA:0000099	neuron
PLANA:0000429	neoblast
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR037131	Homeo_prospero_dom_sf
IPR039350	Prospero_homeodomain
IPR023082	Homeo_prospero_dom
IPR009057	Homeobox-like_sf

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR037131	Homeo-prospero domain superfamily	GENE3D	G3DSA:1.10.10.500		coord: 300..473 e-value: 5.3E-72 score: 242.8
IPR023082	Homeo-prospero domain	PFAM	PF05044	HPD	coord: 315..467 e-value: 2.6E-66 score: 222.3
IPR023082	Homeo-prospero domain	PROSITE	PS51818	HOMEO_PROSPERO	coord: 313..471 score: 80.262
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 264..279
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 294..314
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 247..279
IPR039350	Prospero homeodomain family	PANTHER	PTHR12198	HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26	coord: 69..470
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 315..463

Main menu

PROX-1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Owlery

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