Rho-associated kinase

Overview
NameRho-associated kinase (AFH54449.1)
Smed IDSMED30016875
Length (bp)3891
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Rho-associated kinase (SMED30016875) t-SNE clustered cells

Violin plots show distribution of expression levels for Rho-associated kinase (SMED30016875) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Rho-associated kinase (SMED30016875) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Rho-associated kinase (SMED30016875) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30016875

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 15

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30016875h1SMcG0017566 Contig5319GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
pharynxSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30016875h1SMcG0017566 dd_Smed_v4_2914_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
gutSMED30016875h1SMcG0017566 JN100093smed_ncbi_20240424PMID:22339734
Beane et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
neuronSMED30016875h1SMcG0017566 JN100093smed_ncbi_20240424PMID:22339734
Beane et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30016875h1SMcG0017566 JN100093smed_ncbi_20240424PMID:22339734
Beane et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Rho-associated kinase vs. Ensembl Human
Match: ROCK1 (Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251])

HSP 1 Score: 318.161 bits (814), Expect = 5.068e-90
Identity = 190/529 (35.92%), Postives = 292/529 (55.20%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNI---------SNLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYE--SSIDNNK---------LLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            + YD+      KN K I  FL R+ +   KI  LR+   D+ V+K +G+G FG V LVRHKST+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IK H +  N   +W +  +R+  +PV+ ++S + DT+   +D  +        F     F G  L F GFT+  ++   +L+ A         N            + +LE +L        E E   +  ++KLD    EL   G  ++ L   V +++  + L+    +EY+  +  +N K          LK ++E++ K+ ++S   N ++ QL+  + E  +LL++
Sbjct:   37 LVYDLDFPALRKN-KNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND--QWAWETLRDTVAPVVPDLSSDIDTS--NFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTY--YSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRT 556
[Close]
BLAST of Rho-associated kinase vs. Ensembl Human
Match: ROCK1 (Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251])

HSP 1 Score: 318.161 bits (814), Expect = 5.809e-89
Identity = 190/529 (35.92%), Postives = 292/529 (55.20%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNI---------SNLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYE--SSIDNNK---------LLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            + YD+      KN K I  FL R+ +   KI  LR+   D+ V+K +G+G FG V LVRHKST+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IK H +  N   +W +  +R+  +PV+ ++S + DT+   +D  +        F     F G  L F GFT+  ++   +L+ A         N            + +LE +L        E E   +  ++KLD    EL   G  ++ L   V +++  + L+    +EY+  +  +N K          LK ++E++ K+ ++S   N ++ QL+  + E  +LL++
Sbjct:   37 LVYDLDFPALRKN-KNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND--QWAWETLRDTVAPVVPDLSSDIDTS--NFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTY--YSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRT 556

HSP 2 Score: 62.003 bits (149), Expect = 7.693e-9
Identity = 43/203 (21.18%), Postives = 76/203 (37.44%), Query Frame = 1 
Query: 3112 SWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
             W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    +   +P+I QI+Y   + G+                          R       +  A+     N + H F+P  +     CD C +       PPPALEC  C  + H++HL   E  I  C  + ++      L    S++ +  W++ L
Sbjct: 1137 GWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY--ANEGE-------------------------CRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHL 1312
[Close]
BLAST of Rho-associated kinase vs. Ensembl Human
Match: ROCK2 (Rho associated coiled-coil containing protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:10252])

HSP 1 Score: 317.775 bits (813), Expect = 1.036e-88
Identity = 178/478 (37.24%), Postives = 269/478 (56.28%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFN-----------TYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSD----------AVRELKDREQLINTNKSEYESSIDNNKLLKAKIEN 1641
            + +K I  FL+R+    +KI  L++   D+ V+K +G+G FG V LVRHK+++ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MG IHRD+KPDNMLLDK+GH+KLADFGTC++  + G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +P+D        + +   LT+   R+   G   I+ HP+  N   +W++ +IRE  +PV+ E+S + D++   +D  +        F     F G  L F GFT+ R N           T +  +    +S  I+     L  LE  LS    AK++L  K  +    L KT K+L +          A+R+L+  + L+    +EY+   D+    K  +EN
Sbjct:   63 RKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKND--QWHWDNIRETAAPVVPELSSDIDSS--NFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQ---KKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLEN 531

HSP 2 Score: 69.3218 bits (168), Expect = 5.323e-11
Identity = 45/206 (21.84%), Postives = 78/206 (37.86%), Query Frame = 1 
Query: 3109 ISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVD--AQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
              W+  + ++   K+  Y  E D   + P+  +D+  + H+R  +  +    D   +P+I QI+Y                              ++G S       V+   + +  I  + H F+P  +   T C+ C +       PPPALEC  C  + H++H+   E  I  C    +I      L    S E +  W+S L
Sbjct: 1168 FGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILY-----------------------------ANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRL 1344
[Close]
BLAST of Rho-associated kinase vs. Ensembl Human
Match: ROCK2 (Rho associated coiled-coil containing protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:10252])

HSP 1 Score: 289.271 bits (739), Expect = 4.540e-86
Identity = 151/363 (41.60%), Postives = 224/363 (61.71%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFN 1359
            + +K I  FL+R+    +KI  L++   D+ V+K +G+G FG V LVRHK+++ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MG IHRD+KPDNMLLDK+GH+KLADFGTC++  + G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +P+D        + +   LT+   R+   G   I+ HP+  N   +W++ +IRE  +PV+ E+S + D++   +D  +        F     F G  L F GFT+ R N
Sbjct:   63 RKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKND--QWHWDNIRETAAPVVPELSSDIDSS--NFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYREN 419
[Close]
BLAST of Rho-associated kinase vs. Ensembl Human
Match: CDC42BPG (CDC42 binding protein kinase gamma [Source:HGNC Symbol;Acc:HGNC:29829])

HSP 1 Score: 272.707 bits (696), Expect = 7.362e-74
Identity = 172/574 (29.97%), Postives = 286/574 (49.83%), Query Frame = 1 
Query:  274 SGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNG-FWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFI-DFMSKILTEPTERMDITGI---KSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKK---LSDAVRE-LKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLE 1962
            SG  +  + +  FL   S F  K+ +LR+   DF ++K +G+G FG V +VR + T  ++AMK++ K   +  +    F EERD++ K  S W+    Y F D + LY+VM+Y  GGDL   ++  ED    E   FY  E+VLA+  LH +G++HRD+KPDN+LLD NGH++LADFG+C+R   NG V ++  VGTPDYI PEIL+         G + DWW+ G+  YEL +GETPF  ES    Y  IM ++  L +P D P  P    D + ++L    ER+   G+   ++HP+    G  W    +    +P I E+ G  DT+    D +   +  +    ++  FSG +L F GFT+   +     +     +  +E  +  L + + +LS     K Q +L       EL + +K+   L D + E L+D+  L  T+     S   ++ L                +E+++L   + E    L++ + E C    +           ++ L +  E  E +++     + ++S  EE ++  + L  ++++ +R++ + + Q E
Sbjct:   38 SGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFF--EGVDWE--RLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAA--LERKLQCLEQEKVELSR----KHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDL---------------RQELDRLHRELAEGRAGLQAQEQELCRAQGQ----------QEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWE 576
[Close]
BLAST of Rho-associated kinase vs. Ensembl Celegans
Match: mrck-1 (Serine/threonine-protein kinase mrck-1 [Source:UniProtKB/Swiss-Prot;Acc:O01583])

HSP 1 Score: 265.388 bits (677), Expect = 5.754e-72
Identity = 189/601 (31.45%), Postives = 293/601 (48.75%), Query Frame = 1 
Query:  259 YDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNG-FWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDK---PAKPEFIDFMSKILTEPTERMDITGIKS---HPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDT-NY---ITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSE---------YESSIDNNKLLKAKIENISKLIESSNREIEQLKS---VIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKK----INSLFEEEKSKNQNLINEINTKTRKINEFELQLELISS 1974
            YD  C+ T +  K I  F++       K  KLR+S  DF V+K +G+G FG V +VR +    +YAMKI++K   V  +    F EERD++      W+    Y F D K LY VM+Y  GGD+   +++  D   +    FY  E+VLA++ LH +G++HRD+KPDN+LLD  GH++LADFG+C+R   +G V +N  VGTPDYI PEILR         G E DWW+ GI +YE+ YG TPF  E     Y  IM ++  L +PDD+       E  D + +++     R    G+     HP+    G  WN   IR+   P + EVS  +DT N+   +  D        +        F+G +L F GF++      + L+ A+  +  I   I+   + + +L E  +      ++L+N   EL          V++LK+ + +I  + +E         YES+I     LK +I+ ++K +E      +Q K    ++ E E  LK LK  N  L  E S  +  L  +  +L +   E      Q D+M+     +      EK   + L +E     +++ +FE +L+ I +
Sbjct:   45 YDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFF--EGIDWN--TIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCLQETQPPRVLAAFTGNHLPFVGFSYTHG---SLLSDARSLTDEIRA-IAQRCQGDAELMEKSV--DGFMVELENEKAEL----------VQKLKEAQTIIAQHVAENPRSEEDRNYESTIAQ---LKDEIQILNKRLEDEALAQQQQKPKDEIVAESEKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIET 622
[Close]
BLAST of Rho-associated kinase vs. Ensembl Celegans
Match: mrck-1 (Serine/threonine-protein kinase mrck-1 [Source:UniProtKB/Swiss-Prot;Acc:O01583])

HSP 1 Score: 265.388 bits (677), Expect = 5.754e-72
Identity = 189/601 (31.45%), Postives = 293/601 (48.75%), Query Frame = 1 
Query:  259 YDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNG-FWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDK---PAKPEFIDFMSKILTEPTERMDITGIKS---HPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDT-NY---ITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSE---------YESSIDNNKLLKAKIENISKLIESSNREIEQLKS---VIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKK----INSLFEEEKSKNQNLINEINTKTRKINEFELQLELISS 1974
            YD  C+ T +  K I  F++       K  KLR+S  DF V+K +G+G FG V +VR +    +YAMKI++K   V  +    F EERD++      W+    Y F D K LY VM+Y  GGD+   +++  D   +    FY  E+VLA++ LH +G++HRD+KPDN+LLD  GH++LADFG+C+R   +G V +N  VGTPDYI PEILR         G E DWW+ GI +YE+ YG TPF  E     Y  IM ++  L +PDD+       E  D + +++     R    G+     HP+    G  WN   IR+   P + EVS  +DT N+   +  D        +        F+G +L F GF++      + L+ A+  +  I   I+   + + +L E  +      ++L+N   EL          V++LK+ + +I  + +E         YES+I     LK +I+ ++K +E      +Q K    ++ E E  LK LK  N  L  E S  +  L  +  +L +   E      Q D+M+     +      EK   + L +E     +++ +FE +L+ I +
Sbjct:   45 YDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFF--EGIDWN--TIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCLQETQPPRVLAAFTGNHLPFVGFSYTHG---SLLSDARSLTDEIRA-IAQRCQGDAELMEKSV--DGFMVELENEKAEL----------VQKLKEAQTIIAQHVAENPRSEEDRNYESTIAQ---LKDEIQILNKRLEDEALAQQQQKPKDEIVAESEKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIET 622
[Close]
BLAST of Rho-associated kinase vs. Ensembl Celegans
Match: mrck-1 (Serine/threonine-protein kinase mrck-1 [Source:UniProtKB/Swiss-Prot;Acc:O01583])

HSP 1 Score: 265.003 bits (676), Expect = 8.744e-72
Identity = 188/599 (31.39%), Postives = 292/599 (48.75%), Query Frame = 1 
Query:  259 YDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNG-FWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDK---PAKPEFIDFMSKILTEPTERMDITGIKS---HPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXX--XXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSE---------YESSIDNNKLLKAKIENISKLIESSNREIEQLKS---VIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKK----INSLFEEEKSKNQNLINEINTKTRKINEFELQLELISS 1974
            YD  C+ T +  K I  F++       K  KLR+S  DF V+K +G+G FG V +VR +    +YAMKI++K   V  +    F EERD++      W+    Y F D K LY VM+Y  GGD+   +++  D   +    FY  E+VLA++ LH +G++HRD+KPDN+LLD  GH++LADFG+C+R   +G V +N  VGTPDYI PEILR         G E DWW+ GI +YE+ YG TPF  E     Y  IM ++  L +PDD+       E  D + +++     R    G+     HP+    G  WN   IR+   P + EVS  +DT+    D  +       +        F+G +L F GF++      + L+ A+  +  I   I+   + + +L E  +      ++L+N   EL          V++LK+ + +I  + +E         YES+I     LK +I+ ++K +E      +Q K    ++ E E  LK LK  N  L  E S  +  L  +  +L +   E      Q D+M+     +      EK   + L +E     +++ +FE +L+ I +
Sbjct:   45 YDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFF--EGIDWN--TIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCETQPPRVLAAFTGNHLPFVGFSYTHG---SLLSDARSLTDEIRA-IAQRCQGDAELMEKSV--DGFMVELENEKAEL----------VQKLKEAQTIIAQHVAENPRSEEDRNYESTIAQ---LKDEIQILNKRLEDEALAQQQQKPKDEIVAESEKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIET 620
[Close]
BLAST of Rho-associated kinase vs. Ensembl Celegans
Match: mrck-1 (Serine/threonine-protein kinase mrck-1 [Source:UniProtKB/Swiss-Prot;Acc:O01583])

HSP 1 Score: 265.003 bits (676), Expect = 8.744e-72
Identity = 188/599 (31.39%), Postives = 292/599 (48.75%), Query Frame = 1 
Query:  259 YDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNG-FWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDK---PAKPEFIDFMSKILTEPTERMDITGIKS---HPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXX--XXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSE---------YESSIDNNKLLKAKIENISKLIESSNREIEQLKS---VIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKK----INSLFEEEKSKNQNLINEINTKTRKINEFELQLELISS 1974
            YD  C+ T +  K I  F++       K  KLR+S  DF V+K +G+G FG V +VR +    +YAMKI++K   V  +    F EERD++      W+    Y F D K LY VM+Y  GGD+   +++  D   +    FY  E+VLA++ LH +G++HRD+KPDN+LLD  GH++LADFG+C+R   +G V +N  VGTPDYI PEILR         G E DWW+ GI +YE+ YG TPF  E     Y  IM ++  L +PDD+       E  D + +++     R    G+     HP+    G  WN   IR+   P + EVS  +DT+    D  +       +        F+G +L F GF++      + L+ A+  +  I   I+   + + +L E  +      ++L+N   EL          V++LK+ + +I  + +E         YES+I     LK +I+ ++K +E      +Q K    ++ E E  LK LK  N  L  E S  +  L  +  +L +   E      Q D+M+     +      EK   + L +E     +++ +FE +L+ I +
Sbjct:   45 YDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFF--EGIDWN--TIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCETQPPRVLAAFTGNHLPFVGFSYTHG---SLLSDARSLTDEIRA-IAQRCQGDAELMEKSV--DGFMVELENEKAEL----------VQKLKEAQTIIAQHVAENPRSEEDRNYESTIAQ---LKDEIQILNKRLEDEALAQQQQKPKDEIVAESEKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIET 620
[Close]
BLAST of Rho-associated kinase vs. Ensembl Celegans
Match: sax-1 (Serine/threonine-protein kinase sax-1 [Source:UniProtKB/Swiss-Prot;Acc:Q2L6W9])

HSP 1 Score: 220.32 bits (560), Expect = 5.582e-62
Identity = 122/380 (32.11%), Postives = 190/380 (50.00%), Query Frame = 1 
Query:  340 KIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNG-FWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCI------RT-----------------------------KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG----IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFN 1359
            ++ + R++++DF  +K +G+G FG V LV+   T ++YAMKI+ KS  V          ERDI+++   DW++K +Y+F D   LY+VME++PGGD+   + + +  ++E T FY  E  LA++ +H++GFIHRD+KPDN+LLD  GH+KL+DFG C       RT                             +N +      VGTPDYI PE+ +  G          DWW+ G+++YE+  G  PF  E     Y+ ++ ++ TL++P D P   E    + +   E   R+   G    IK  P++      WN   IRE   P+   V   DDT+     P++     ++  I      G    F  FT+ RF+
Sbjct:   76 RLKRTRLTVNDFESLKVIGRGAFGEVRLVQKHDTGHIYAMKILRKSEMVEKEQTAHVRAERDILSEADCDWVVKMYYSFQDYSNLYLVMEFLPGGDMMTLLIKKDTLTEEATQFYIAEAALAIQFIHSLGFIHRDIKPDNLLLDARGHVKLSDFGLCTGLKKFHRTDHYRNWPSTLPPDFISKPFESKRKAETWKRNRRAYAYSTVGTPDYIAPEVFQPNGYTK-----SCDWWSLGVIMYEMLIGYPPFCSELPQETYRKVINWQQTLVFPSDVPISIEAKATIKRFCCEAERRLGNHGGLDEIKQCPFVKR--IDWNH--IRERPPPIRVTVKSIDDTSNFDDFPDEDLTWPTSTLIRPEEQPGRRGEFVDFTYKRFD 446
[Close]
BLAST of Rho-associated kinase vs. Ensembl Fly
Match: Rok (gene:FBgn0026181 transcript:FBtr0340151)

HSP 1 Score: 311.997 bits (798), Expect = 3.204e-87
Identity = 157/381 (41.21%), Postives = 231/381 (60.63%), Query Frame = 1 
Query:  295 KPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISN 1422
            K I+ +  ++   + +I +LR+++ DF  IK +G G FG V LVRHKS+  VYAMK + K   +    + F WEER IMA  +S+W+++  + F D K LY+VM++MPGGD+   M +  D  ++   FY ME+VLA++ +HNMGF+HRD+KPDNMLLD  GH+KLADFGTC+R   NG+V ++  VGTPDYI PE+L++ G+ D E G E DWW+ GI +YE+ +GETPF  +S    Y  IM +K++L +P +     +    +   LT+ T+R+   G   IK+HP+  N    W+F +IRE   PV+ E+S +DDT    ++  +R       F     F G +L F GFT+     Y  L+     +   E N++N
Sbjct:   61 KNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDY-DIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGV-DNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDT--WSFDNIRESVPPVVPELSSDDDTR--NFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYT--GDYQLLSSDTVDAESKEANVAN 433

HSP 2 Score: 71.2478 bits (173), Expect = 5.998e-12
Identity = 98/413 (23.73%), Postives = 185/413 (44.79%), Query Frame = 1 
Query: 2518 EVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKS-MPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHS-------IDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLS----GEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQK 3720
            E++KKL   K  EYE+    ++ Q  K   ++++  +M  +K++ + T  LDK + E+    L  +  V K+ E+M    S +P+  ++ +         +++R+L+ +LS+E+ KF + L +  D +  C   Q   +++  E++ K   I++L   LN       + +D    +D++    EG L +  K   +    W   + ++   K+  Y   N ++  H+       +DL  V H+R  +  + +  D   +P+I Q++Y     G+           S+R  + S L V     S       + +P G I  + H FV + +   T C++C +       PP A EC  C+ +IH+EH+         K+   P +    L    + E ++ W++ L  LK  QK
Sbjct:  961 ELHKKLGQ-KAAEYED----LVQQHKK---QQEELALMRSSKDEEI-TKLLDKCKNEV----LLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQDLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADNDP---EDSQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFY---NSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLY----AGEGA---------SHRPDEQSQLDV-----SVLHGNCNEERP-GTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARL--LKRIQK 1333
[Close]
BLAST of Rho-associated kinase vs. Ensembl Fly
Match: Rok (gene:FBgn0026181 transcript:FBtr0340153)

HSP 1 Score: 311.997 bits (798), Expect = 3.386e-87
Identity = 157/381 (41.21%), Postives = 231/381 (60.63%), Query Frame = 1 
Query:  295 KPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISN 1422
            K I+ +  ++   + +I +LR+++ DF  IK +G G FG V LVRHKS+  VYAMK + K   +    + F WEER IMA  +S+W+++  + F D K LY+VM++MPGGD+   M +  D  ++   FY ME+VLA++ +HNMGF+HRD+KPDNMLLD  GH+KLADFGTC+R   NG+V ++  VGTPDYI PE+L++ G+ D E G E DWW+ GI +YE+ +GETPF  +S    Y  IM +K++L +P +     +    +   LT+ T+R+   G   IK+HP+  N    W+F +IRE   PV+ E+S +DDT    ++  +R       F     F G +L F GFT+     Y  L+     +   E N++N
Sbjct:   52 KNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDY-DIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGV-DNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDT--WSFDNIRESVPPVVPELSSDDDTR--NFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYT--GDYQLLSSDTVDAESKEANVAN 424

HSP 2 Score: 69.3218 bits (168), Expect = 2.679e-11
Identity = 99/421 (23.52%), Postives = 187/421 (44.42%), Query Frame = 1 
Query: 2518 EVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKS-MPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNN-------DMIPKESP-SDELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHS-------IDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLS----GEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQK 3720
            E++KKL   K  EYE+    ++ Q  K   ++++  +M  +K++ + T  LDK + E+    L  +  V K+ E+M    S +P+  ++ +         +++R+L+ +LS+E+ KF + L +  D +  C   Q   +++  E++ K   I++L   LN        D  P++S  S  LS+  + +      +   +  +  H   W   + ++   K+  Y   N ++  H+       +DL  V H+R  +  + +  D   +P+I Q++Y     G+           S+R  + S L V     S       + +P G I  + H FV + +   T C++C +       PP A EC  C+ +IH+EH+         K+   P +    L    + E ++ W++ L  LK  QK
Sbjct:  952 ELHKKLGQ-KAAEYED----LVQQHKK---QQEELALMRSSKDEEI-TKLLDKCKNEV----LLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQDLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADNDPEDSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGH--GWKRQYVIVSSRKIIFY---NSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLY----AGEGA---------SHRPDEQSQLDV-----SVLHGNCNEERP-GTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARL--LKRIQK 1333
[Close]
BLAST of Rho-associated kinase vs. Ensembl Fly
Match: Rok (gene:FBgn0026181 transcript:FBtr0074286)

HSP 1 Score: 311.997 bits (798), Expect = 3.721e-87
Identity = 157/381 (41.21%), Postives = 231/381 (60.63%), Query Frame = 1 
Query:  295 KPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISN 1422
            K I+ +  ++   + +I +LR+++ DF  IK +G G FG V LVRHKS+  VYAMK + K   +    + F WEER IMA  +S+W+++  + F D K LY+VM++MPGGD+   M +  D  ++   FY ME+VLA++ +HNMGF+HRD+KPDNMLLD  GH+KLADFGTC+R   NG+V ++  VGTPDYI PE+L++ G+ D E G E DWW+ GI +YE+ +GETPF  +S    Y  IM +K++L +P +     +    +   LT+ T+R+   G   IK+HP+  N    W+F +IRE   PV+ E+S +DDT    ++  +R       F     F G +L F GFT+     Y  L+     +   E N++N
Sbjct:   61 KNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDY-DIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGV-DNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDT--WSFDNIRESVPPVVPELSSDDDTR--NFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYT--GDYQLLSSDTVDAESKEANVAN 433

HSP 2 Score: 68.9366 bits (167), Expect = 2.945e-11
Identity = 99/421 (23.52%), Postives = 187/421 (44.42%), Query Frame = 1 
Query: 2518 EVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKS-MPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNN-------DMIPKESP-SDELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHS-------IDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLS----GEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQK 3720
            E++KKL   K  EYE+    ++ Q  K   ++++  +M  +K++ + T  LDK + E+    L  +  V K+ E+M    S +P+  ++ +         +++R+L+ +LS+E+ KF + L +  D +  C   Q   +++  E++ K   I++L   LN        D  P++S  S  LS+  + +      +   +  +  H   W   + ++   K+  Y   N ++  H+       +DL  V H+R  +  + +  D   +P+I Q++Y     G+           S+R  + S L V     S       + +P G I  + H FV + +   T C++C +       PP A EC  C+ +IH+EH+         K+   P +    L    + E ++ W++ L  LK  QK
Sbjct:  961 ELHKKLGQ-KAAEYED----LVQQHKK---QQEELALMRSSKDEEI-TKLLDKCKNEV----LLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQDLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADNDPEDSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGH--GWKRQYVIVSSRKIIFY---NSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLY----AGEGA---------SHRPDEQSQLDV-----SVLHGNCNEERP-GTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARL--LKRIQK 1342
[Close]
BLAST of Rho-associated kinase vs. Ensembl Fly
Match: Rok (gene:FBgn0026181 transcript:FBtr0340152)

HSP 1 Score: 311.612 bits (797), Expect = 3.854e-87
Identity = 157/381 (41.21%), Postives = 231/381 (60.63%), Query Frame = 1 
Query:  295 KPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISN 1422
            K I+ +  ++   + +I +LR+++ DF  IK +G G FG V LVRHKS+  VYAMK + K   +    + F WEER IMA  +S+W+++  + F D K LY+VM++MPGGD+   M +  D  ++   FY ME+VLA++ +HNMGF+HRD+KPDNMLLD  GH+KLADFGTC+R   NG+V ++  VGTPDYI PE+L++ G+ D E G E DWW+ GI +YE+ +GETPF  +S    Y  IM +K++L +P +     +    +   LT+ T+R+   G   IK+HP+  N    W+F +IRE   PV+ E+S +DDT    ++  +R       F     F G +L F GFT+     Y  L+     +   E N++N
Sbjct:   61 KNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDY-DIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGV-DNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDT--WSFDNIRESVPPVVPELSSDDDTR--NFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYT--GDYQLLSSDTVDAESKEANVAN 433

HSP 2 Score: 69.3218 bits (168), Expect = 2.298e-11
Identity = 103/453 (22.74%), Postives = 197/453 (43.49%), Query Frame = 1 
Query: 2518 EVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKS-MPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNN-------DMIPKESP-SDELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHS-------IDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLS----GEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKA------------EIQIAPNTYYRSVRVPGR 3780
            E++KKL   K  EYE+    ++ Q  K   ++++  +M  +K++ + T  LDK + E+    L  +  V K+ E+M    S +P+  ++ +         +++R+L+ +LS+E+ KF + L +  D +  C   Q   +++  E++ K   I++L   LN        D  P++S  S  LS+  + +      +   +  +  H   W   + ++   K+  Y   N ++  H+       +DL  V H+R  +  + +  D   +P+I Q++Y     G+           S+R  + S L V     S       + +P G I  + H FV + +   T C++C +       PP A EC  C+ +IH+EH+         K+   P +    L    + E ++ W++ L  LK  QK                +I+P +   + ++P R
Sbjct:  961 ELHKKLGQ-KAAEYED----LVQQHKK---QQEELALMRSSKDEEI-TKLLDKCKNEV----LLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQDLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADNDPEDSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGH--GWKRQYVIVSSRKIIFY---NSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLY----AGEGA---------SHRPDEQSQLDV-----SVLHGNCNEERP-GTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARL--LKRIQKSGYKAASYNNNSTDGSKISPRSSGAAYKIPQR 1374
[Close]
BLAST of Rho-associated kinase vs. Ensembl Fly
Match: gek (gene:FBgn0023081 transcript:FBtr0072287)

HSP 1 Score: 254.988 bits (650), Expect = 1.677e-68
Identity = 143/375 (38.13%), Postives = 208/375 (55.47%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNG-FWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFI----DFMSKILTEPTERMDITGIK---SHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTF 1347
            + YD   + + +  K +  FL     F   + KLR+S  DF ++K +G+G FG V +V+  ST+ VYAMKI++K   +  +    F EERD++      W+    Y F D   LY+VM+Y  GGDL   +++ ED   ++   FY  E++LA+  +H + ++HRD+KPDN+LLDK GH++LADFG+C+R  K+G V++N  VGTPDYI PEILR         G E DWW+ G+ +YE+ YGETPF  ES    Y  IM +++    P  +    +      D + K++  P  R+   GI+    HP+    G  W   +IR+  +P + EVS   DT+    D ND R   S     N  FSG +L F GFTF
Sbjct:   60 VLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFV--GIDWK--NIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTF 430
[Close]
BLAST of Rho-associated kinase vs. Ensembl Zebrafish
Match: rock1 (Rho-associated, coiled-coil containing protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-100712-2])

HSP 1 Score: 322.398 bits (825), Expect = 1.235e-90
Identity = 192/526 (36.50%), Postives = 294/526 (55.89%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTF---NRFNTYNFLAHAKGKSTGIEGN--ISNLTELETKLSEAELAKQQL-----------SLKLDNTTNELGKT---QKKLSDAVRELKDREQLINTNKSEYESSIDNNK-----------LLKAKIENISKLIESSNREIEQLKSVIGEKENLLKS 1725
            + YD+      KN K I  FL R+ +   KI +LR+   D+ V+K +G+G FG V LVRHK+T+ VYAMK++ K   +  S + F WEERDIMA  +S+W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K+G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K+ L +P+D     +    +   LT+   R+   G   IK H +  N   +W + +IRE  +PV+ E+S + DT+   +D  +        F     F G  L F GFT+   N F+  + +  +  +S+  E    + NL +   +L E   ++ QL           + KLD    EL +    +K +   +  L+  + +I    +EY+   D               LK ++E++ K I  +N +I QL++ +GE  +LL++
Sbjct:   39 LVYDLDFPALRKN-KSIDDFLKRYKDTISKIRELRMKAEDYEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSNWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFPEDSDISKDAKSLICAFLTDREVRLGRNGVDEIKRHGFFKND--QWTWENIRETAAPVVPELSCDTDTS--NFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTYYSNNLFSQESTIKTSDKRSSTKEDKSLLENLQKRIYQLEEQVHSEMQLRDEMEQKCRASNTKLDKIMKELDEESNLRKSVEANMSILEKDKIMIQHRATEYQRKADQEAEKRRNLENEVSTLKEQLEDLRK-ISQNNDKIAQLQNQLGEANDLLRA 556

HSP 2 Score: 71.2478 bits (173), Expect = 7.601e-12
Identity = 96/401 (23.94%), Postives = 160/401 (39.90%), Query Frame = 1 
Query: 2590 KMKIDLEEKKQ-QIMDMTKEKMVLTNDLDK-VQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSR------KKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQT-WQDQCK---ELKSELEDKNNIIKDLMKSLNNDMIPKESPS------DELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGP----INVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWC------PDAIEIFLFKVESKEAKNAWISCLN 3699
            K K +  E+ Q Q  +   E+  LTN +    +K L  ++      V K+ E+M N K M     R      +KKEK +       R+L+ +L++EK KF     +     NE Q  W ++C    EL+ +L+ K + I+ L + LN+  +  ++ S      DEL    N  +S       +       +  W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    + + +P+I QI+Y                              ++G    R    V++ P G     +  + H F+P  +   T C+ C +       PPPALEC  C  + H++HL   E  I  C        A ++ L  +   E K  WI  L 
Sbjct:  960 KEKTEFNERIQAQEQEFAAEREELTNSIKANYEKALNIERTLKTQAVNKLAEIM-NRKDMKDQKKRGSTTDLRKKEKEN-------RKLQLELNQEKEKFNHMAFKYQKELNEMQAQWAEECTYRNELQMQLDSKESDIEQLREKLNDLQLRVDNSSVTSLQPDELD--SNIAESRLEGWLAIPNRANIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETDEIPRIFQILY-----------------------------ANEG--ECRKETDVESVPQGDKANCLPHKGHEFIPTLYHFPTNCEACSKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDMITPCKVNYDVTSARDMLLLALSQDEQKK-WIGHLG 1318
[Close]
BLAST of Rho-associated kinase vs. Ensembl Zebrafish
Match: rock2a (rho-associated, coiled-coil containing protein kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030115-3])

HSP 1 Score: 318.161 bits (814), Expect = 4.392e-89
Identity = 286/992 (28.83%), Postives = 476/992 (47.98%), Query Frame = 1 
Query:  169 NKLSLIENEIFNPXXXXXXXXXXXXXXXISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKN-GKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISN----------LTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMM-NDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLK----LIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLD----KVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQ-----------TWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSI 3039
            N+L  +E  I +P S + L++LLD  +++  D+      KN K I+ FL+R+      I +L++   DF  +K +G+G FG V LVRHK+++ VYAMK++ K   +  S + F WEERDIMA   S W+++    F D + LY+VMEYMPGGDL + +T   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLD+ GH+KLADFGTC++    G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ IYE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+  +G   IK HP+  N   +W FS IRE  +PV+ E+S + DT+   +D  +        F     F G  L F GFT+  F     L      +   +  +SN          L  LE +L+    AK +L  K  + +N L K  K+L + +                                N  K +ES+ R++E+ K+++  K              S E      S +  K+ L     E+     Q+D MKK        K++N ++ NE N   +K      QL+  ++  +    + + ++    +S       +           M+ N   ++E E  +LQ  L+ EK              ++ T     +S LQ R+   ED+ R + Q ++  E+EK Q+  Q+K+ +   E    ++D        Q+    E+        +  + N ++ S+E  + +A + E+ +KL++ +     +E     L   N  +  D ++  Q++ ++ + K  LT ++     K+++E+Q      K  +T+ D  + N     QLS+ +  EK     I  I +++  L K+ ++ +++ ++ +    E Q            ++ Q +ELK E E+KN + KD+ ++L      ++S + +L I
Sbjct:   11 NRLRQLEAMIKDPRSAINLESLLDSMNALVLDLDFPALRKN-KNIENFLNRYEKVMNHIRELQMRPEDFDRVKVIGRGAFGEVQLVRHKASQKVYAMKVLSKFEMIKRSDSAFFWEERDIMAFADSPWVVQLCCAFQDDRSLYMVMEYMPGGDLVN-LTSTYDVPEKWAKFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDRYGHLKLADFGTCMKMDGTGMVHCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISQEGKNIICAFLTDREVRLGRSGVEEIKRHPFFRND--QWTFSTIRETAAPVVPELSSDIDTS--NFDEIEEDKGEVETFPTPKAFVGNQLPFVGFTY--FKENQLLNAVNSSAMKNDHPVSNREDNLALQKKLHCLEEQLNNEMQAKDELEQKYRSNSNRLEKITKELDEEM--------------------------------NSRKGLESTLRQLEREKALLQHK--------------SVESHRRAESEADRKRCLEN---EVNSLRDQLDEMKK--------KNQNSHISNEKNIHLQK------QLDEANALLRAESEVATRMRKTQTESSKQLQQLEAHVRELQDKCCMLENSKLTLERENISLQAALDTEK--------------REQTQGSETISDLQARITGMEDEVRQMRQALSKAETEKRQL--QEKLTDMEKEKSNNQIDMTYKLKMLQQGLEQEEAAHKATKARLADKNMISESIEGAKSEA-VKELEQKLQEERSSKQRVENRVLELEKKNSMLDCDYKQSLQKLEELRRHKERLTEEVKNLNLKIEQEVQ------KRTLTQNDLKVQN----QQLSTLRTSEKQLKQEINHILEIKRSLEKQNMELRKERQDSDGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKNKLYKDVQQNLQELQEERDSLAAQLEI 903

HSP 2 Score: 71.633 bits (174), Expect = 7.126e-12
Identity = 86/382 (22.51%), Postives = 159/382 (41.62%), Query Frame = 1 
Query: 2605 LEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKI---RQLETDLSKEKVKFQEKL----KECNDTKNECQTWQDQCKELKSELEDKNNII---KDLMKSLNNDMIPKESPSD--ELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCP---DAIEIFLFKVESKEAKNAWISCL 3696
            L+E +  + ++  E+  +T     ++K+LQS++      V K+ E+M N K +    SR+     D D  RK    R+L+ +L  E+ K    +    +E ND + +         EL+  L+ K++ I   + L+ SLN   +   S S   ++   ++ ++        L       +  W   + V+   K+  Y  E D   + P+  +D+  + H+R  +  +    D   +P+I QI+Y   + G+  + Q +  +  +                 +SS I           + H F+P  +   T C+ C +   +   PPPALEC  C  + H++H+   E  I  C       +  L    S+E +  W+S L
Sbjct:  982 LKEAEDYLQNLKNEEQSITQVKLALEKQLQSERTLKTQAVNKLAEIM-NRKEVRGGGSRRG---NDTDVRRKEKENRKLQLELRSEREKLNSTIIKYQREINDIQAQLLDESQVRIELQMALDSKDSDIEQLRSLLNSLNVQSLDSASMSSGPDMDTDESLLEIRLEGWLSLPVRNNTKRFGWERKYVVVSSKKILFYNSEQDKEHSNPYMVLDIDKLFHVRSVTQTDVYRADAKEIPRIFQILY--ANEGESKKEQELEPLPGD-----------------KSSYICH---------KGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEVIAPCRVDMSTAKNLLLLASSQEDQQKWVSRL 1331
[Close]
BLAST of Rho-associated kinase vs. Ensembl Zebrafish
Match: rock2a (rho-associated, coiled-coil containing protein kinase 2a [Source:ZFIN;Acc:ZDB-GENE-030115-3])

HSP 1 Score: 317.775 bits (813), Expect = 5.218e-89
Identity = 286/992 (28.83%), Postives = 476/992 (47.98%), Query Frame = 1 
Query:  169 NKLSLIENEIFNPXXXXXXXXXXXXXXXISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKN-GKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISN----------LTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMM-NDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLK----LIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLD----KVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQ-----------TWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSI 3039
            N+L  +E  I +P S + L++LLD  +++  D+      KN K I+ FL+R+      I +L++   DF  +K +G+G FG V LVRHK+++ VYAMK++ K   +  S + F WEERDIMA   S W+++    F D + LY+VMEYMPGGDL + +T   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLD+ GH+KLADFGTC++    G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ IYE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+  +G   IK HP+  N   +W FS IRE  +PV+ E+S + DT+   +D  +        F     F G  L F GFT+  F     L      +   +  +SN          L  LE +L+    AK +L  K  + +N L K  K+L + +                                N  K +ES+ R++E+ K+++  K              S E      S +  K+ L     E+     Q+D MKK        K++N ++ NE N   +K      QL+  ++  +    + + ++    +S       +           M+ N   ++E E  +LQ  L+ EK              ++ T     +S LQ R+   ED+ R + Q ++  E+EK Q+  Q+K+ +   E    ++D        Q+    E+        +  + N ++ S+E  + +A + E+ +KL++ +     +E     L   N  +  D ++  Q++ ++ + K  LT ++     K+++E+Q      K  +T+ D  + N     QLS+ +  EK     I  I +++  L K+ ++ +++ ++ +    E Q            ++ Q +ELK E E+KN + KD+ ++L      ++S + +L I
Sbjct:   11 NRLRQLEAMIKDPRSAINLESLLDSMNALVLDLDFPALRKN-KNIENFLNRYEKVMNHIRELQMRPEDFDRVKVIGRGAFGEVQLVRHKASQKVYAMKVLSKFEMIKRSDSAFFWEERDIMAFADSPWVVQLCCAFQDDRSLYMVMEYMPGGDLVN-LTSTYDVPEKWAKFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDRYGHLKLADFGTCMKMDGTGMVHCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISQEGKNIICAFLTDREVRLGRSGVEEIKRHPFFRND--QWTFSTIRETAAPVVPELSSDIDTS--NFDEIEEDKGEVETFPTPKAFVGNQLPFVGFTY--FKENQLLNAVNSSAMKNDHPVSNREDNLALQKKLHCLEEQLNNEMQAKDELEQKYRSNSNRLEKITKELDEEM--------------------------------NSRKGLESTLRQLEREKALLQHK--------------SVESHRRAESEADRKRCLEN---EVNSLRDQLDEMKK--------KNQNSHISNEKNIHLQK------QLDEANALLRAESEVATRMRKTQTESSKQLQQLEAHVRELQDKCCMLENSKLTLERENISLQAALDTEK--------------REQTQGSETISDLQARITGMEDEVRQMRQALSKAETEKRQL--QEKLTDMEKEKSNNQIDMTYKLKMLQQGLEQEEAAHKATKARLADKNMISESIEGAKSEA-VKELEQKLQEERSSKQRVENRVLELEKKNSMLDCDYKQSLQKLEELRRHKERLTEEVKNLNLKIEQEVQ------KRTLTQNDLKVQN----QQLSTLRTSEKQLKQEINHILEIKRSLEKQNMELRKERQDSDGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKNKLYKDVQQNLQELQEERDSLAAQLEI 903

HSP 2 Score: 71.2478 bits (173), Expect = 8.840e-12
Identity = 86/382 (22.51%), Postives = 159/382 (41.62%), Query Frame = 1 
Query: 2605 LEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKI---RQLETDLSKEKVKFQEKL----KECNDTKNECQTWQDQCKELKSELEDKNNII---KDLMKSLNNDMIPKESPSD--ELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCP---DAIEIFLFKVESKEAKNAWISCL 3696
            L+E +  + ++  E+  +T     ++K+LQS++      V K+ E+M N K +    SR+     D D  RK    R+L+ +L  E+ K    +    +E ND + +         EL+  L+ K++ I   + L+ SLN   +   S S   ++   ++ ++        L       +  W   + V+   K+  Y  E D   + P+  +D+  + H+R  +  +    D   +P+I QI+Y   + G+  + Q +  +  +                 +SS I           + H F+P  +   T C+ C +   +   PPPALEC  C  + H++H+   E  I  C       +  L    S+E +  W+S L
Sbjct:  982 LKEAEDYLQNLKNEEQSITQVKLALEKQLQSERTLKTQAVNKLAEIM-NRKEVRGGGSRRG---NDTDVRRKEKENRKLQLELRSEREKLNSTIIKYQREINDIQAQLLDESQVRIELQMALDSKDSDIEQLRSLLNSLNVQSLDSASMSSGPDMDTDESLLEIRLEGWLSLPVRNNTKRFGWERKYVVVSSKKILFYNSEQDKEHSNPYMVLDIDKLFHVRSVTQTDVYRADAKEIPRIFQILY--ANEGESKKEQELEPLPGD-----------------KSSYICH---------KGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEVIAPCRVDMSTAKNLLLLASSQEDQQKWVSRL 1331
[Close]
BLAST of Rho-associated kinase vs. Ensembl Zebrafish
Match: rock2b (rho-associated, coiled-coil containing protein kinase 2b [Source:ZFIN;Acc:ZDB-GENE-060125-2])

HSP 1 Score: 311.997 bits (798), Expect = 5.387e-87
Identity = 236/703 (33.57%), Postives = 365/703 (51.92%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDT-NY---ITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVR-ELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKS-XXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQK-SELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIE 2325
            ++ D++     KN K I AFL R+      + +L+V L DF  +K +G+G FG V LVRHK ++ VYAMK + K   V  S + F WEERDIMA + S W+++    F D K LY+VME+MPGGDL   +T   D  +E   FY  E+VLA++ +H++GFIHRD+KPDNMLLD+NGH+KLADFGTC++    G V+ +  VGTPDYI PE+L + G      G E DWW+ G+ IYEL  G+TPF  ES    Y  IM +K++L +PDD        D +   L+    R+  TG   IK HP+  N   +W F  IR+  +PV+ E+S + DT N+   I  DP       +  F     F+G  L F GFT+ R +      +   +   IE +  N TE                      +N+L K  KKL +  + E++ +E+L N                K +I N  + +E  ++++E+  +   E E+ L+SL+ E   L  +            Q++ KA  E + K    + +  +     E K KNQ  I+ ++ +  K    E QLE +S++ +  +     L+ A +++    + L+   + L+ RL  + N    +E++K +LQ  L  EK ++ +  ETI D L   +   + ++  +++ L+ AE +KR L + +  +E EK++ E
Sbjct:   39 LALDLNHPALRKN-KNIDAFLSRYEKAVCNLKELQVKLDDFDRVKLIGRGAFGAVQLVRHKVSQQVYAMKQLSKFEMVKRSDSAFFWEERDIMAFSQSPWIVQLCCAFQDEKYLYLVMEFMPGGDLV-TLTSNYDIPEEWAQFYTAEVVLALDAIHSLGFIHRDIKPDNMLLDRNGHLKLADFGTCMKMDSTGMVRCDTAVGTPDYISPEVLMSQGGTGY-YGRECDWWSVGVFIYELLVGDTPFYSESLVGTYGKIMDHKNSLTFPDDIEMSKNAKDLICAFLSSREVRLGRTGVDEIKCHPFFKND--QWTFDTIRDTMAPVVPELSSDIDTSNFDDDIKDDP-----IGTETFPPPRAFAGNQLPFVGFTYFREDQLLTQQNKCSEEDIIEDHGLNHTE----------------------SNDLEKRLKKLEEKFKHEMQAKEELEN----------------KCRIAN--QRLEKLSKDLEEEVNARQEAEDNLRSLEKEKVLLKHQ----------RTQSVRKAGLETDRKRLLENEVSSLKEQLAELKKKNQ--ISHLSAE--KNIHLERQLEEVSAKLQAELEESERLKKAQIEAFRQSQQLELSLRELQERLAQLENSRLVLEQDKLSLQTSLELEKRERNAGSETITD-LQGRIYGLEGELKHIKSSLSKAEVEKRQLQEDLTTLEKEKNKQE 676

HSP 2 Score: 66.2402 bits (160), Expect = 2.857e-10
Identity = 54/217 (24.88%), Postives = 89/217 (41.01%), Query Frame = 1 
Query: 3109 ISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWC------PDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEI 3732
              W   + V+   K+  Y  E D   + PF  +D+  + H+R  +  +    D   +P+I QI+Y   + G+                K   L V+    + RS  I    P+     + H FV   +   ++C++C +       PPPALEC  C+ + H++H+   E  +  C        A E+ L    S E +  W+S L  LK   +K  I
Sbjct: 1159 FGWDKKYVVVSSKKILFYDSEQDREQSSPFMILDIDKLFHVRPVTQTDVYRADPREIPRIFQILY--ANEGES---------------KKEELPVESLSVTERSLCI----PH-----KGHEFVLTLYHFPSSCEVCPRPLWHVFRPPPALECRRCRVKCHKDHIDRKEEVLAPCRVNYDMSTAKEMLLL-ANSTEEQKKWVSRL--LKRVPRKPSI 1346
[Close]
BLAST of Rho-associated kinase vs. Ensembl Zebrafish
Match: rock2b (rho-associated, coiled-coil containing protein kinase 2b [Source:ZFIN;Acc:ZDB-GENE-060125-2])

HSP 1 Score: 311.612 bits (797), Expect = 6.072e-87
Identity = 236/703 (33.57%), Postives = 365/703 (51.92%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDT-NY---ITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVR-ELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKS-XXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQK-SELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIE 2325
            ++ D++     KN K I AFL R+      + +L+V L DF  +K +G+G FG V LVRHK ++ VYAMK + K   V  S + F WEERDIMA + S W+++    F D K LY+VME+MPGGDL   +T   D  +E   FY  E+VLA++ +H++GFIHRD+KPDNMLLD+NGH+KLADFGTC++    G V+ +  VGTPDYI PE+L + G      G E DWW+ G+ IYEL  G+TPF  ES    Y  IM +K++L +PDD        D +   L+    R+  TG   IK HP+  N   +W F  IR+  +PV+ E+S + DT N+   I  DP       +  F     F+G  L F GFT+ R +      +   +   IE +  N TE                      +N+L K  KKL +  + E++ +E+L N                K +I N  + +E  ++++E+  +   E E+ L+SL+ E   L  +            Q++ KA  E + K    + +  +     E K KNQ  I+ ++ +  K    E QLE +S++ +  +     L+ A +++    + L+   + L+ RL  + N    +E++K +LQ  L  EK ++ +  ETI D L   +   + ++  +++ L+ AE +KR L + +  +E EK++ E
Sbjct:   39 LALDLNHPALRKN-KNIDAFLSRYEKAVCNLKELQVKLDDFDRVKLIGRGAFGAVQLVRHKVSQQVYAMKQLSKFEMVKRSDSAFFWEERDIMAFSQSPWIVQLCCAFQDEKYLYLVMEFMPGGDLV-TLTSNYDIPEEWAQFYTAEVVLALDAIHSLGFIHRDIKPDNMLLDRNGHLKLADFGTCMKMDSTGMVRCDTAVGTPDYISPEVLMSQGGTGY-YGRECDWWSVGVFIYELLVGDTPFYSESLVGTYGKIMDHKNSLTFPDDIEMSKNAKDLICAFLSSREVRLGRTGVDEIKCHPFFKND--QWTFDTIRDTMAPVVPELSSDIDTSNFDDDIKDDP-----IGTETFPPPRAFAGNQLPFVGFTYFREDQLLTQQNKCSEEDIIEDHGLNHTE----------------------SNDLEKRLKKLEEKFKHEMQAKEELEN----------------KCRIAN--QRLEKLSKDLEEEVNARQEAEDNLRSLEKEKVLLKHQ----------RTQSVRKAGLETDRKRLLENEVSSLKEQLAELKKKNQ--ISHLSAE--KNIHLERQLEEVSAKLQAELEESERLKKAQIEAFRQSQQLELSLRELQERLAQLENSRLVLEQDKLSLQTSLELEKRERNAGSETITD-LQGRIYGLEGELKHIKSSLSKAEVEKRQLQEDLTTLEKEKNKQE 676

HSP 2 Score: 66.2402 bits (160), Expect = 2.931e-10
Identity = 54/217 (24.88%), Postives = 89/217 (41.01%), Query Frame = 1 
Query: 3109 ISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWC------PDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEI 3732
              W   + V+   K+  Y  E D   + PF  +D+  + H+R  +  +    D   +P+I QI+Y   + G+                K   L V+    + RS  I    P+     + H FV   +   ++C++C +       PPPALEC  C+ + H++H+   E  +  C        A E+ L    S E +  W+S L  LK   +K  I
Sbjct: 1159 FGWDKKYVVVSSKKILFYDSEQDREQSSPFMILDIDKLFHVRPVTQTDVYRADPREIPRIFQILY--ANEGES---------------KKEELPVESLSVTERSLCI----PH-----KGHEFVLTLYHFPSSCEVCPRPLWHVFRPPPALECRRCRVKCHKDHIDRKEEVLAPCRVNYDMSTAKEMLLL-ANSTEEQKKWVSRL--LKRVPRKPSI 1346
[Close]
BLAST of Rho-associated kinase vs. Ensembl Xenopus
Match: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1 [Source:NCBI gene;Acc:100496057])

HSP 1 Score: 316.62 bits (810), Expect = 1.421e-88
Identity = 186/529 (35.16%), Postives = 292/529 (55.20%), Query Frame = 1 
Query:  259 YDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKG------KSTGIEGNI-----SNLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSIDNN-----------KLLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            YD+      KN K I  FL+R+ +   K+  LR+   D+ V+K +G+G FG V LVRHKS++ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  + G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +P+D     E  + +   LT+   R+   G   IK HP+  N   +W +  +R+  +PV+ +++ + DT+   +D  +        F     F G  L F GFT+  ++   +L            S+ ++ N+      N+ +LE +L        E E   +  ++KLD    EL   G  +K L   V + +  + ++    +EY+   +               LK ++E+  K+ ++S   N +I QL+  + E  +LL++
Sbjct:   39 YDLDFPAMRKN-KNIDNFLNRYKDTMSKVRDLRMKADDYEVVKVIGRGAFGEVQLVRHKSSRKVYAMKLLSKLEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNREGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPEDSDISKEAKNLICAFLTDREVRLGRNGVEEIKRHPFFKND--QWAWETLRDTVAPVVPDLTSDIDTS--NFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY--YSNRQYLDDPSANPNDNRSSSTVDKNLVENLQKNIYQLEEQLHNEMQLKDEMEQKCRMSNIKLDKIMKELDEEGNQRKNLESLVAQTEKEKMMLQHRINEYQRKAEQESEKRRNVENEVSTLKDQLEDFKKISQTSHITNEKIAQLQKQLEEANDLLRT 558

HSP 2 Score: 61.6178 bits (148), Expect = 1.056e-8
Identity = 41/203 (20.20%), Postives = 76/203 (37.44%), Query Frame = 1 
Query: 3112 SWLPYFAVLKPFKLELY---QGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
             W   + V+   K+  Y   Q +  + P   +D+  + H+R  +  +    +   +P+I QI+Y   + G                         + R       +   +    +N + H F+P  +     C+ C +       PPPALEC  C  + H++HL   E  I  C  + ++      L    ++E +  W+S L
Sbjct: 1143 GWKKQYVVVSSKKILFYNDEQNKEQSSPSMVLDIDKLFHVRAVTQGDVYRANTEEIPRIFQILY--ANEG-------------------------ECRKDVELEPVQQTEKTNFLNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHKDHLDKKEELISPCKVSYDVTSARDMLLLACTQEEQTKWVSHL 1318
[Close]
BLAST of Rho-associated kinase vs. Ensembl Xenopus
Match: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1 [Source:NCBI gene;Acc:100496057])

HSP 1 Score: 316.235 bits (809), Expect = 2.283e-88
Identity = 186/529 (35.16%), Postives = 292/529 (55.20%), Query Frame = 1 
Query:  259 YDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKG------KSTGIEGNI-----SNLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSIDNN-----------KLLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            YD+      KN K I  FL+R+ +   K+  LR+   D+ V+K +G+G FG V LVRHKS++ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  + G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +P+D     E  + +   LT+   R+   G   IK HP+  N   +W +  +R+  +PV+ +++ + DT+   +D  +        F     F G  L F GFT+  ++   +L            S+ ++ N+      N+ +LE +L        E E   +  ++KLD    EL   G  +K L   V + +  + ++    +EY+   +               LK ++E+  K+ ++S   N +I QL+  + E  +LL++
Sbjct:   39 YDLDFPAMRKN-KNIDNFLNRYKDTMSKVRDLRMKADDYEVVKVIGRGAFGEVQLVRHKSSRKVYAMKLLSKLEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNREGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPEDSDISKEAKNLICAFLTDREVRLGRNGVEEIKRHPFFKND--QWAWETLRDTVAPVVPDLTSDIDTS--NFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY--YSNRQYLDDPSANPNDNRSSSTVDKNLVENLQKNIYQLEEQLHNEMQLKDEMEQKCRMSNIKLDKIMKELDEEGNQRKNLESLVAQTEKEKMMLQHRINEYQRKAEQESEKRRNVENEVSTLKDQLEDFKKISQTSHITNEKIAQLQKQLEEANDLLRT 558

HSP 2 Score: 61.2326 bits (147), Expect = 1.252e-8
Identity = 41/203 (20.20%), Postives = 76/203 (37.44%), Query Frame = 1 
Query: 3112 SWLPYFAVLKPFKLELY---QGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
             W   + V+   K+  Y   Q +  + P   +D+  + H+R  +  +    +   +P+I QI+Y   + G                         + R       +   +    +N + H F+P  +     C+ C +       PPPALEC  C  + H++HL   E  I  C  + ++      L    ++E +  W+S L
Sbjct: 1126 GWKKQYVVVSSKKILFYNDEQNKEQSSPSMVLDIDKLFHVRAVTQGDVYRANTEEIPRIFQILY--ANEG-------------------------ECRKDVELEPVQQTEKTNFLNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHKDHLDKKEELISPCKVSYDVTSARDMLLLACTQEEQTKWVSHL 1301
[Close]
BLAST of Rho-associated kinase vs. Ensembl Xenopus
Match: ROCK1 (Rho-associated, coiled-coil containing protein kinase 1 [Source:NCBI gene;Acc:100496057])

HSP 1 Score: 315.849 bits (808), Expect = 3.181e-88
Identity = 186/529 (35.16%), Postives = 292/529 (55.20%), Query Frame = 1 
Query:  259 YDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKG------KSTGIEGNI-----SNLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSIDNN-----------KLLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            YD+      KN K I  FL+R+ +   K+  LR+   D+ V+K +G+G FG V LVRHKS++ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  + G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +P+D     E  + +   LT+   R+   G   IK HP+  N   +W +  +R+  +PV+ +++ + DT+   +D  +        F     F G  L F GFT+  ++   +L            S+ ++ N+      N+ +LE +L        E E   +  ++KLD    EL   G  +K L   V + +  + ++    +EY+   +               LK ++E+  K+ ++S   N +I QL+  + E  +LL++
Sbjct:   39 YDLDFPAMRKN-KNIDNFLNRYKDTMSKVRDLRMKADDYEVVKVIGRGAFGEVQLVRHKSSRKVYAMKLLSKLEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNREGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPEDSDISKEAKNLICAFLTDREVRLGRNGVEEIKRHPFFKND--QWAWETLRDTVAPVVPDLTSDIDTS--NFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY--YSNRQYLDDPSANPNDNRSSSTVDKNLVENLQKNIYQLEEQLHNEMQLKDEMEQKCRMSNIKLDKIMKELDEEGNQRKNLESLVAQTEKEKMMLQHRINEYQRKAEQESEKRRNVENEVSTLKDQLEDFKKISQTSHITNEKIAQLQKQLEEANDLLRT 558

HSP 2 Score: 60.8474 bits (146), Expect = 1.959e-8
Identity = 41/203 (20.20%), Postives = 76/203 (37.44%), Query Frame = 1 
Query: 3112 SWLPYFAVLKPFKLELY---QGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
             W   + V+   K+  Y   Q +  + P   +D+  + H+R  +  +    +   +P+I QI+Y   + G+                          R       +   +    +N + H F+P  +     C+ C +       PPPALEC  C  + H++HL   E  I  C  + ++      L    ++E +  W+S L
Sbjct: 1127 GWKKQYVVVSSKKILFYNDEQNKEQSSPSMVLDIDKLFHVRAVTQGDVYRANTEEIPRIFQILY--ANEGE-------------------------CRKDVELEPVQQTEKTNFLNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHKDHLDKKEELISPCKVSYDVTSARDMLLLACTQEEQTKWVSHL 1302
[Close]
BLAST of Rho-associated kinase vs. Ensembl Xenopus
Match: med18 (mediator complex subunit 18 [Source:Xenbase;Acc:XB-GENE-1002158])

HSP 1 Score: 314.694 bits (805), Expect = 6.008e-88
Identity = 181/484 (37.40%), Postives = 274/484 (56.61%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNT--------YNFLAHAKGKSTGIEGNISNL-----TELETKLSEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIEN 1641
            I  D+      KN K I  FL+R+     ++ KL++   D+ V+K +G+G FG V LVRHK ++ VYAMK++ K   +  S + F WEERDIMA  +S W+++ F  F D K LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA+  +H+MG IHRD+KPDNMLLDK GH+KLADFGTC++  + G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ ++E+  G+TPF  +S    Y  IM +K++L +P+D        + +   LT+   R+   G   IK HP+  N   +WN+ +IRE  +PV+ E++ + DT+   +D  +     +  F N   F+G  L F GFT+ R N          N  A    +S  ++  I+ L      E++TK  E E   + ++L+L+ T  EL      +K +    R+L+  + L+    +EY+   +N+   K  +EN
Sbjct:   34 IVLDLDFPALRKN-KNIDNFLNRYEKIVREVRKLQMKAEDYDVVKVIGRGAFGEVQLVRHKGSQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDEKHLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALNAIHSMGLIHRDVKPDNMLLDKYGHLKLADFGTCMKMDQTGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPEDVEISVHAKNLICAFLTDREVRLGRNGIEDIKQHPFFKND--QWNWDNIRETVAPVVPELASDIDTS--NFDDIEDDKGDAETFPNPKAFAGNQLPFIGFTYYRENLESSRNCKEKNSSAQPMKESAHLQKVINKLEEQLHNEMQTK-DELEQKFRAVNLRLEKTVKELDEEANARKSIESTTRQLEREKALLQHKSTEYQRKAENDADRKRSLEN 509

HSP 2 Score: 66.2402 bits (160), Expect = 3.982e-10
Identity = 56/246 (22.76%), Postives = 93/246 (37.80%), Query Frame = 1 
Query: 3109 ISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDA-QPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCLNSLKEYQKKA-----EIQIAPN-----TYYRSVRVPGRHSP 3789
              W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    D   +P+I QI+Y                              ++G S       VD  + +  I  + H F+P  +   T+CD C +       PP ALEC  C  + H++H+   E  I  C    +I      L    S E +  W+S L  +K+  KK      + + +P      +  +S+R P R  P
Sbjct: 1107 FGWNKKYVVVSSRKILFYDSEQDKELSNPSMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILY-----------------------------ANEGESKKEQEFQVDPLEKSNYICHKGHEFIPTLYHFPTSCDACMKPLWHMFKPPAALECRRCHIKCHKDHMDKKEEIIAPCKVNYDISTAKNLLLLANSTEEQQKWVSRL--VKKIPKKPPASDHQARSSPRPPAKASLNQSMRRPSRQLP 1321
[Close]
BLAST of Rho-associated kinase vs. Ensembl Xenopus
Match: med18 (mediator complex subunit 18 [Source:Xenbase;Acc:XB-GENE-1002158])

HSP 1 Score: 313.153 bits (801), Expect = 2.831e-87
Identity = 182/488 (37.30%), Postives = 275/488 (56.35%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTY-----------NFLAHA-KGKSTGIEGNISNL-----TELETKLSEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIEN 1641
            I  D+      KN K I  FL+R+     ++ KL++   D+ V+K +G+G FG V LVRHK ++ VYAMK++ K   +  S + F WEERDIMA  +S W+++ F  F D K LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA+  +H+MG IHRD+KPDNMLLDK GH+KLADFGTC++  + G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ ++E+  G+TPF  +S    Y  IM +K++L +P+D        + +   LT+   R+   G   IK HP+  N   +WN+ +IRE  +PV+ E++ + DT+   +D  +     +  F N   F+G  L F GFT+ R N             N  A   K +S  ++  I+ L      E++TK  E E   + ++L+L+ T  EL      +K +    R+L+  + L+    +EY+   +N+   K  +EN
Sbjct:   39 IVLDLDFPALRKN-KNIDNFLNRYEKIVREVRKLQMKAEDYDVVKVIGRGAFGEVQLVRHKGSQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDEKHLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALNAIHSMGLIHRDVKPDNMLLDKYGHLKLADFGTCMKMDQTGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPEDVEISVHAKNLICAFLTDREVRLGRNGIEDIKQHPFFKND--QWNWDNIRETVAPVVPELASDIDTS--NFDDIEDDKGDAETFPNPKAFAGNQLPFIGFTYYRENLLLSESSRNCKEKNSSAQPMKEQSAHLQKVINKLEEQLHNEMQTK-DELEQKFRAVNLRLEKTVKELDEEANARKSIESTTRQLEREKALLQHKSTEYQRKAENDADRKRSLEN 518

HSP 2 Score: 66.6254 bits (161), Expect = 2.927e-10
Identity = 56/246 (22.76%), Postives = 93/246 (37.80%), Query Frame = 1 
Query: 3109 ISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDA-QPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCLNSLKEYQKKA-----EIQIAPN-----TYYRSVRVPGRHSP 3789
              W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    D   +P+I QI+Y                              ++G S       VD  + +  I  + H F+P  +   T+CD C +       PP ALEC  C  + H++H+   E  I  C    +I      L    S E +  W+S L  +K+  KK      + + +P      +  +S+R P R  P
Sbjct: 1154 FGWNKKYVVVSSRKILFYDSEQDKELSNPSMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILY-----------------------------ANEGESKKEQEFQVDPLEKSNYICHKGHEFIPTLYHFPTSCDACMKPLWHMFKPPAALECRRCHIKCHKDHMDKKEEIIAPCKVNYDISTAKNLLLLANSTEEQQKWVSRL--VKKIPKKPPASDHQARSSPRPPAKASLNQSMRRPSRQLP 1368
[Close]
BLAST of Rho-associated kinase vs. Ensembl Mouse
Match: Rock1 (Rho-associated coiled-coil containing protein kinase 1 [Source:MGI Symbol;Acc:MGI:107927])

HSP 1 Score: 310.457 bits (794), Expect = 4.482e-93
Identity = 188/498 (37.75%), Postives = 284/498 (57.03%), Query Frame = 1 
Query:  184 IENEIFNPXXXXXXXXXXXXXXXISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKG----KSTGIEGNISNLTELETKLSEAELAKQQL-----------SLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSID 1608
            I+N + +P S++  D LLD   ++ YD+      KN K I  FL R+ +   KI  LR+   D+ V+K +G+G FG V LVRHKST+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IK H +  N   +W +  +R+  +PV+ ++S + DT+   +D  +        F     F G  L F GFT+  ++   +L  A       S+ ++ ++ +L +   KL E    + QL           +LKLD    EL   G  ++ L  AV +++  + L+    +EY+  ++
Sbjct:   14 IDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKN-KNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND--QWAWETLRDTVAPVVPDLSSDIDTS--NFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY--YSNRRYLPSANASENRSSSNVDKSLESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNLKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVE 502
[Close]
BLAST of Rho-associated kinase vs. Ensembl Mouse
Match: Rock1 (Rho-associated coiled-coil containing protein kinase 1 [Source:MGI Symbol;Acc:MGI:107927])

HSP 1 Score: 322.398 bits (825), Expect = 1.355e-90
Identity = 190/529 (35.92%), Postives = 290/529 (54.82%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNI---------SNLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSIDNN-----------KLLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            + YD+      KN K I  FL R+ +   KI  LR+   D+ V+K +G+G FG V LVRHKST+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IK H +  N   +W +  +R+  +PV+ ++S + DT+   +D  +        F     F G  L F GFT+  ++   +L  A         N+           + +LE +L        E E   +  +LKLD    EL   G  ++ L  AV +++  + L+    +EY+  ++               LK ++E++ K  ++S   N ++ QL+  + E  +LL++
Sbjct:   37 LVYDLDFPALRKN-KNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND--QWAWETLRDTVAPVVPDLSSDIDTS--NFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY--YSNRRYLPSANASENRSSSNVDKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNLKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEKRRNIENEVSTLKDQLEDLRKASQTSQLANEKLTQLQKQLEEANDLLRT 556

HSP 2 Score: 59.6918 bits (143), Expect = 2.676e-8
Identity = 41/203 (20.20%), Postives = 75/203 (36.95%), Query Frame = 1 
Query: 3112 SWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
             W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    +   +P+I QI+Y   + G+                          R       +   +     N + H F+P  +     C+ C +       PPPALEC  C  + H++HL   E  I  C  + ++      L    S++ +  W++ L
Sbjct: 1137 GWKKQYVVVSSKKILFYNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY--ANEGE-------------------------CRKDIEVEPVQQGEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHL 1312
[Close]
BLAST of Rho-associated kinase vs. Ensembl Mouse
Match: Rock2 (Rho-associated coiled-coil containing protein kinase 2 [Source:MGI Symbol;Acc:MGI:107926])

HSP 1 Score: 313.538 bits (802), Expect = 1.502e-87
Identity = 176/475 (37.05%), Postives = 266/475 (56.00%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNIS--------NLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAV----------RELKDREQLINTNKSEYESSIDNNKLLKAKIEN 1641
            + +K I  FL+R+    +KI  L++   D+ V+K +G+G FG V LVRHK+++ VYAMK++ K   +  S + F WEERDIMA  +S W+++ F  F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MG IHRD+KPDNMLLDK+GH+KLADFGTC++  + G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ ++E+  G+TPF  +S    Y  IM +K++L +P+D        + +   LT+   R+   G   IK HP+  N   +WN+ +IRE  +PV+ E+S + D++   +D  +        F     F G  L F GFT+ R N     +    ++  I+   S         L  LE  LS    AK++L  K  +    L KT K+L + +          R+L+  + L+    +EY+   D+    K  +EN
Sbjct:   63 RKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKND--QWNWDNIRETAAPVVPELSSDIDSS--NFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYFRENLLLSDSPPCRENDAIQTRKSEESQEIQKKLYALEEHLSSEVQAKEELEQKCKSINTRLEKTAKELEEEITLRKSVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLEN 531

HSP 2 Score: 68.9366 bits (167), Expect = 4.113e-11
Identity = 45/206 (21.84%), Postives = 78/206 (37.86%), Query Frame = 1 
Query: 3109 ISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVD--AQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
              W+  + ++   K+  Y  E D   + P+  +D+  + H+R  +  +    D   +P+I QI+Y                              ++G S       V+   + +  I  + H F+P  +   T C+ C +       PPPALEC  C  + H++H+   E  I  C    +I      L    S E +  W+S L
Sbjct: 1168 FGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILY-----------------------------ANEGESKKEPEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLLLANSTEEQQKWVSRL 1344
[Close]
BLAST of Rho-associated kinase vs. Ensembl Mouse
Match: Rock2 (Rho-associated coiled-coil containing protein kinase 2 [Source:MGI Symbol;Acc:MGI:107926])

HSP 1 Score: 313.153 bits (801), Expect = 3.432e-87
Identity = 176/475 (37.05%), Postives = 266/475 (56.00%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNIS--------NLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAV----------RELKDREQLINTNKSEYESSIDNNKLLKAKIEN 1641
            + +K I  FL+R+    +KI  L++   D+ V+K +G+G FG V LVRHK+++ VYAMK++ K   +  S + F WEERDIMA  +S W+++ F  F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MG IHRD+KPDNMLLDK+GH+KLADFGTC++  + G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ ++E+  G+TPF  +S    Y  IM +K++L +P+D        + +   LT+   R+   G   IK HP+  N   +WN+ +IRE  +PV+ E+S + D++   +D  +        F     F G  L F GFT+ R N     +    ++  I+   S         L  LE  LS    AK++L  K  +    L KT K+L + +          R+L+  + L+    +EY+   D+    K  +EN
Sbjct:   63 RKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKND--QWNWDNIRETAAPVVPELSSDIDSS--NFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYFRENLLLSDSPPCRENDAIQTRKSEESQEIQKKLYALEEHLSSEVQAKEELEQKCKSINTRLEKTAKELEEEITLRKSVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLEN 531

HSP 2 Score: 68.9366 bits (167), Expect = 5.176e-11
Identity = 45/206 (21.84%), Postives = 78/206 (37.86%), Query Frame = 1 
Query: 3109 ISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVD--AQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
              W+  + ++   K+  Y  E D   + P+  +D+  + H+R  +  +    D   +P+I QI+Y                              ++G S       V+   + +  I  + H F+P  +   T C+ C +       PPPALEC  C  + H++H+   E  I  C    +I      L    S E +  W+S L
Sbjct: 1225 FGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILY-----------------------------ANEGESKKEPEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLLLANSTEEQQKWVSRL 1401
[Close]
BLAST of Rho-associated kinase vs. Ensembl Mouse
Match: Rock1 (Rho-associated coiled-coil containing protein kinase 1 [Source:MGI Symbol;Acc:MGI:107927])

HSP 1 Score: 307.76 bits (787), Expect = 8.867e-87
Identity = 177/490 (36.12%), Postives = 272/490 (55.51%), Query Frame = 1 
Query:  370 DFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNI---------SNLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSIDNN-----------KLLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            D+ V+K +G+G FG V LVRHKST+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IK H +  N   +W +  +R+  +PV+ ++S + DT+   +D  +        F     F G  L F GFT+  ++   +L  A         N+           + +LE +L        E E   +  +LKLD    EL   G  ++ L  AV +++  + L+    +EY+  ++               LK ++E++ K  ++S   N ++ QL+  + E  +LL++
Sbjct:    5 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND--QWAWETLRDTVAPVVPDLSSDIDTS--NFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY--YSNRRYLPSANASENRSSSNVDKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNLKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEKRRNIENEVSTLKDQLEDLRKASQTSQLANEKLTQLQKQLEEANDLLRT 486
[Close]
BLAST of Rho-associated kinase vs. UniProt/SwissProt
Match: sp|P70335|ROCK1_MOUSE (Rho-associated protein kinase 1 OS=Mus musculus OX=10090 GN=Rock1 PE=1 SV=1)

HSP 1 Score: 322.398 bits (825), Expect = 9.475e-90
Identity = 190/529 (35.92%), Postives = 290/529 (54.82%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNI---------SNLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSIDNN-----------KLLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            + YD+      KN K I  FL R+ +   KI  LR+   D+ V+K +G+G FG V LVRHKST+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IK H +  N   +W +  +R+  +PV+ ++S + DT+   +D  +        F     F G  L F GFT+  ++   +L  A         N+           + +LE +L        E E   +  +LKLD    EL   G  ++ L  AV +++  + L+    +EY+  ++               LK ++E++ K  ++S   N ++ QL+  + E  +LL++
Sbjct:   37 LVYDLDFPALRKN-KNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND--QWAWETLRDTVAPVVPDLSSDIDTS--NFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY--YSNRRYLPSANASENRSSSNVDKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNLKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEKRRNIENEVSTLKDQLEDLRKASQTSQLANEKLTQLQKQLEEANDLLRT 556

HSP 2 Score: 59.6918 bits (143), Expect = 1.872e-7
Identity = 41/203 (20.20%), Postives = 75/203 (36.95%), Query Frame = 1 
Query: 3112 SWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
             W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    +   +P+I QI+Y   + G+                          R       +   +     N + H F+P  +     C+ C +       PPPALEC  C  + H++HL   E  I  C  + ++      L    S++ +  W++ L
Sbjct: 1137 GWKKQYVVVSSKKILFYNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY--ANEGE-------------------------CRKDIEVEPVQQGEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHL 1312
[Close]
BLAST of Rho-associated kinase vs. UniProt/SwissProt
Match: sp|Q63644|ROCK1_RAT (Rho-associated protein kinase 1 OS=Rattus norvegicus OX=10116 GN=Rock1 PE=1 SV=1)

HSP 1 Score: 322.398 bits (825), Expect = 1.016e-89
Identity = 230/717 (32.08%), Postives = 370/717 (51.60%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKG----KSTGIEGNIS-----NLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYESSIDNN-----------KLLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLEL-ISSRAKDNVL---LDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRV 2277
            + YD+      KN K I  FL R+ +   KI  LR+   D+ V+K +G+G FG V LVRHKST+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IK H +  N   +W +  +R+  +PV+ ++S + DT+   +D  +        F     F G  L F GFT+  ++   +L  A       S+ ++ N+       + +LE +L        E E   +  ++KLD    EL   G  ++ L  AV +++  + L+    +EY+  ++               LK ++E++ K  +SS   N ++ QL+  + E  +LL++                   S     L K+H E+ +  SQ++      SL  E + +N+ L N  +   +   + +  LE     R  D+ +   L + + S   + + L+   +  +        M+N     E+EKN L+ DLN       +L++I+ +L ++V   K+  + L ++  + E+ K V
Sbjct:   37 LVYDLDFPALRKN-KNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND--QWAWETLRDTVAPVVPDLSSDIDTS--NFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY--YSNRRYLPSANPSENRSSSNVDKNVQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEKRRNVENEVSTLKDQLEDLRKASQSSQLANEKLTQLQKQLEEANDLLRT------------------ESDTAVRLRKSHTEMSKSVSQLE------SLNRELQERNRMLENSKSQADKDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLN---HSEKEKNNLEIDLN------YKLKSIQQRLEQEVNEHKVTKARLTDKHQSIEEAKSV 711
[Close]
BLAST of Rho-associated kinase vs. UniProt/SwissProt
Match: sp|A8WVU9|ROCK_CAEBR (Rho-associated protein kinase let-502 OS=Caenorhabditis briggsae OX=6238 GN=let-502 PE=3 SV=2)

HSP 1 Score: 318.546 bits (815), Expect = 4.065e-89
Identity = 183/499 (36.67%), Postives = 284/499 (56.91%), Query Frame = 1 
Query:  295 KPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERM---DITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTF-NRFNTYNFL---AHAKGKSTGIEGNISNLTELETKLSEAELAKQQ---LSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSI--------DNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLK 1731
            K +  F+ R+    E +  LR+  +DF  +K +G+G FG V LVRH  T  VYAMK+++K   +  + + F WEERDIMA  +S+W+++  Y F D + LY+VMEYMPGGDL + MT  E  S++ T FY  E+V A+  LHNMG+IHRD+KPDNML+ ++GH+KLADFGTC++   NG V+ +  VGTPDYI PE+LRN G  D E G E DWW+ G+ IYE+  GETPF  E+  + Y NIM ++++L +PD+     +  D + K L+   ER+   ++  I++H +  N   +W F  +++   P++  +  +DDT +   +   R  + +++F     F+G  L F GFT+ N ++    L   A + G   G+E     + +  T      + ++Q   + ++LD+   EL    + L D++   + R +LI T K+   S I        DN + L+   ++ +K+ E S  E+   K   GE EN L   +
Sbjct:   42 KSVDNFISRYERIVESVAALRMKATDFRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYE-VSEKWTRFYTAEIVEALAALHNMGYIHRDVKPDNMLISRSGHIKLADFGTCVKMNSNGVVRCSTAVGTPDYISPEVLRNQG-KDSEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYANIMNHQTSLRFPDEPLISTQAKDIIKKFLSAAPERLGKNNVDEIRNHKFFKND--EWTFETLKDATPPIVPSLKSDDDTTHFE-EIETRDRDNASDFQLPKTFNGNQLPFIGFTYSNEYSPVKKLLNGASSNGVQNGVENKPVVVQQPLTNGHSTGIPEEQYEEVVIELDSKKREL----ESLKDSISRTEIRAKLIETEKNSLSSKINDLERELKDNKERLRLGADSDTKVNELS-VELRMSKEYNGEMENELSKFR 530

HSP 2 Score: 87.0409 bits (214), Expect = 8.414e-16
Identity = 60/223 (26.91%), Postives = 101/223 (45.29%), Query Frame = 1 
Query: 3115 WLPYFAVLKPFKLELYQGEND-NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKI-QWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPNTYYRSVRVPG 3777
            W  YF +L  +   +Y  E   N    +I+  ++ H+R  ++A+  +VD N LP+I  I+Y      DD       S +S+R   +S L++ + R                   + H F  + + + T CD C +  SD++ P PA EC NC  + H+EH+  G   + ++   + E+ L     KE  N W+S L    E  + A + ++  +  R V  PG
Sbjct:  997 WTNYFVILNEYAFTIYTDEKHLNSVVLTIEAGAMAHVRHVTSADLRNVDDNQLPKIFHIMY------DD------TSSNSSRHASNSDLSICEPREE---------------GWKRHDFQELSYHTRTYCDDCGKKLSDFIRPTPAFECKNCHYKTHKEHIAQGTITMCRYTGLSRELVLMGTH-KEVCNQWVSQLRRFIEASRPANVSVSRVSSRRHVGGPG 1191
[Close]
BLAST of Rho-associated kinase vs. UniProt/SwissProt
Match: sp|O77819|ROCK1_RABIT (Rho-associated protein kinase 1 OS=Oryctolagus cuniculus OX=9986 GN=ROCK1 PE=1 SV=1)

HSP 1 Score: 320.472 bits (820), Expect = 4.847e-89
Identity = 192/529 (36.29%), Postives = 293/529 (55.39%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNI-----SNLTELETKLSEAELAKQQL-----------SLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYE--SSIDNNK---------LLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            + YD+      KN K I  FL R+ +   KI  LR+   D+ V+K +G+G FG V LVRHKST+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IK H +  N   +W +  +R+  +PV+ ++S + DT+   +D  +        F     F G  L F GFT+  ++   +L+ A         N+      NL +   KL E    + QL           ++KLD    EL   G  ++ L   V +++  + L+    +EY+  +  +N K          LK ++E++ K+ ++S   N ++ QL+  + E  +LL++
Sbjct:   37 LVYDLDFPALRKN-KNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND--QWAWETLRDTVAPVVPDLSSDIDTS--NFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTY--YSNRRYLSPANPNDNRTSSNVDKSLQENLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLAQLQKQLEEANDLLRT 556

HSP 2 Score: 61.2326 bits (147), Expect = 6.346e-8
Identity = 42/203 (20.69%), Postives = 76/203 (37.44%), Query Frame = 1 
Query: 3112 SWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
             W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    +   +P+I QI+Y   + G+                          R       +  A+     N + H F+P  +     C+ C +       PPPALEC  C  + H++HL   E  I  C  + ++      L    S++ +  W++ L
Sbjct: 1137 GWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY--ANEGE-------------------------CRKDVEVEPVQQAEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHL 1312
[Close]
BLAST of Rho-associated kinase vs. UniProt/SwissProt
Match: sp|Q13464|ROCK1_HUMAN (Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1)

HSP 1 Score: 318.161 bits (814), Expect = 2.790e-88
Identity = 190/529 (35.92%), Postives = 292/529 (55.20%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNI---------SNLTELETKL-------SEAELAKQQLSLKLDNTTNEL---GKTQKKLSDAVRELKDREQLINTNKSEYE--SSIDNNK---------LLKAKIENISKLIESS---NREIEQLKSVIGEKENLLKS 1725
            + YD+      KN K I  FL R+ +   KI  LR+   D+ V+K +G+G FG V LVRHKST+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IK H +  N   +W +  +R+  +PV+ ++S + DT+   +D  +        F     F G  L F GFT+  ++   +L+ A         N            + +LE +L        E E   +  ++KLD    EL   G  ++ L   V +++  + L+    +EY+  +  +N K          LK ++E++ K+ ++S   N ++ QL+  + E  +LL++
Sbjct:   37 LVYDLDFPALRKN-KNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND--QWAWETLRDTVAPVVPDLSSDIDTS--NFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTY--YSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRT 556

HSP 2 Score: 62.003 bits (149), Expect = 3.694e-8
Identity = 43/203 (21.18%), Postives = 76/203 (37.44%), Query Frame = 1 
Query: 3112 SWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
             W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    +   +P+I QI+Y   + G+                          R       +  A+     N + H F+P  +     CD C +       PPPALEC  C  + H++HL   E  I  C  + ++      L    S++ +  W++ L
Sbjct: 1137 GWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY--ANEGE-------------------------CRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHL 1312
[Close]
BLAST of Rho-associated kinase vs. TrEMBL
Match: I0AYW1 (Rho-associated kinase OS=Schmidtea mediterranea OX=79327 GN=ROCK PE=2 SV=1)

HSP 1 Score: 2250.32 bits (5830), Expect = 0.000e+0
Identity = 1214/1216 (99.84%), Postives = 1214/1216 (99.84%), Query Frame = 1 
Query:  148 MNSEDIVNKLSLIENEIFNPXXXXXXXXXXXXXXXISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPNTYYRSVRVPGRHSPAI 3795
            MNSEDIVNKLSLIENEIFNPSSDLYLDNLLDLASSISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFE ESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPNDRRNNISNNFINNNYFSGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSID NKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEISSSKISLSTLKQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSEDLELLQKEKQALESRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAQLEEQEECFLEKEKKFENDKKFLETNSMNISMENDRLKAELVEVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIKDNEMKSLEGKLEMLKKGKGKHKISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPNTYYRSVRVPGRHSPAI
Sbjct:    1 MNSEDIVNKLSLIENEIFNPSSDLYLDNLLDLASSISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEVESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPNDRRNNISNNFINNNYFSGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDXNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEISSSKISLSTLKQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSEDLELLQKEKQALESRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAQLEEQEECFLEKEKKFENDKKFLETNSMNISMENDRLKAELVEVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIKDNEMKSLEGKLEMLKKGKGKHKISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPNTYYRSVRVPGRHSPAI 1216
[Close]
BLAST of Rho-associated kinase vs. TrEMBL
Match: A0A183UG06 (Uncharacterized protein OS=Toxocara canis OX=6265 GN=TCNE_LOCUS7426 PE=4 SV=1)

HSP 1 Score: 417.927 bits (1073), Expect = 3.859e-121
Identity = 349/1222 (28.56%), Postives = 586/1222 (47.95%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERM---DITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTF-NRFNTYNFL---AHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEE---IEEKSSQI--------DNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQL-----ELISSRAKD-NVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQK----SELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESE----KDQIEQQKKMFE---SMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLK--LIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQS--------------------------DKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSI----RKIRQLETDLSKEKVKFQEKL----KECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIKDNXXXXXX---XXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI--FLFKVESKEAKNAWISCLNSLKEYQ 3717
            + ++ I  F+ R+ +  +++ +LR+  SDF +IK +G+G +G V LVRH ++KNVYAMK+++K+  +  + + F WEERDIMA  +S+W++K  Y F D + LY+VMEYMPGGDL + MT   D S++   FY+ ELVLA++ LH MG+IHRD+KPDNML+ + GH+KLADFGTC+R   NG VK    VGTPDYI PE+L   G   +  G E DWWA GI +YE+  GETPF  +S    Y  I  +++ L +PDD        D + K L++  ER+    I  IKSHP+  N    W F +I+    PV+ E+ G+DD ++   D   +  N +++F     F+G  L F GFT+ N     + +         S  ++  +  L  L +  S+ E  +++L         ++   Q +L D  R+L+     +NT K++  +S++    LK+K+E+  K +E  N E+ +    + E E   +  +TE   L  ++++       L++ L KA E    ++E+  Q+        DN+++      E+  K ++L  EI +   +    + QL      +++ R KD N L+D  ++   ++                    ++N+L +  ++   L  DL  E  Q+    SEL+ + D+    V N +  V  L+  L  + + KR L  + + I S     + Q+E  ++ FE   S + + K E++ +    E  E+    ++ +    ++   +  M   +E++RL   + E N    D +  ++E E   L    Q+ + +L  K   I  +++++  L   L  VQ+ELQS                          +K+   + + K++E+M N     QL+ R KKEK     +    R+I +LE DL+ +K K++++L    +E    K      +   + L+++LE   ++   + +    +    E  S+ +++      +      +  +  +   K +  W   FAV     L  +  +ND  PF +I   ++ H R  SAA+     +N LP+I QI Y   D+                   SS+       S +R   +  A  N       H  V + F   T+CDLC +  S++L PPPA EC  C+ R H+EHL  G   I  C   ++    L    + EA + W+  L    +Y+
Sbjct:   84 RRTRNIDNFVSRYHDMVKRVCELRLRGSDFQLIKVIGRGAYGEVQLVRHNASKNVYAMKLLNKNEMIRRADSAFFWEERDIMAHANSEWIVKLHYAFQDARFLYMVMEYMPGGDLVNLMTSY-DVSEKWARFYSAELVLALDALHTMGYIHRDVKPDNMLITRFGHVKLADFGTCLRMGPNGTVKCTSAVGTPDYISPEVLELQGTEGV-YGREVDWWAVGIFVYEMLVGETPFYADSLMGTYTRIRNHETELNFPDDVEMSDHAKDLIRKFLSDAKERLGKDGIESIKSHPFFINDD--WTFDNIQRAVPPVVPELKGDDDASHFD-DIEPKEANPADSFQIPKSFAGSQLPFIGFTYSNELGPISAIQKKVQTAADSLHVQAALEELNRLSSVDSQRETERRELE-------KQMAACQIQLKDLSRKLEMERDEMNT-KAKMITSLEEQLSLKSKVEDRVKELERVNTEVNEKCRSLAECEERARKQQTE---LHTKLAAQTELSKELEEKLQKAGEYENVVQEQMQQLRVQLNVERDNVRRAQQRATEQSEKMESLRAEIASMREREVVLKCQLNKLNENVVNERDKDENRLIDDEIKKKNIR--------------------LVNELQATHKKVEQLSGDLEQESRQRMVAQSELQAVSDQ----VANLQNTVQFLEEELRRSREDKRRLETKTHEISSANRLLQRQLEDIREQFETESSFINIYKTEVNAM--NEELSEKTRRLEQLEEHQRREEERSREMIAQLESERLARRIAEENLSATDKEKTMLEVEVRQLV---QRHEKELAAKDAAIQLISQKEEELQKALQNVQRELQSLTERESPRGSVSPEQRIHDLEGQLEREKMFKMTAINKLEEVMAN----RQLNERSKKEKVSRGDVQRRERRIAELERDLNLQKTKYEDRLSQFTRENEQLKIALMEEEKMNESLRNDLESFQHLETVMNEQKKRERGDHECTSEMVTLSPALTVTDADFNNEGVVSVRLTVKRRHQWQECFAVFNSSGLFFFINQNDRQPFQAIQTENLCHARHVSAADVRTAGENQLPRIFQIFYAIEDSLSR--------------RSSSSEISQSPLSGSREDKLDKALWN------RHELVELTFHMPTSCDLCVKPLSNFLRPPPAYECKRCRMRFHREHL--GNETIPQCRQTVDARDMLIMAPTTEACDRWVQQLKKFLDYR 1234
[Close]
BLAST of Rho-associated kinase vs. TrEMBL
Match: A0A158N7Z8 (Uncharacterized protein OS=Onchocerca volvulus OX=6282 PE=4 SV=1)

HSP 1 Score: 400.208 bits (1027), Expect = 1.279e-114
Identity = 348/1224 (28.43%), Postives = 572/1224 (46.73%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLT-----ELETKLSEA-ELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRL--ISMMNDLSSMEEEKNALQHDLNNEKIQK----SELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIES----EKDQIEQQKKMFE---SMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLK--LIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQS------------------------DKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEK----LKECNDTKNECQTWQDQCKELKSELE---------------DKNNIIKD--------LMKSLN-NDMIPKESPSDELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI--FLFKVESKEAKNAWISCLNSLKEYQ 3717
            + +K I  F+ R+S   +++  LR+  SDF +IK +G+G +G V LVRH +++NVYAMK+++K+  V  + + F WEERDIMA   S+W+++  Y F D + LY+VMEYMPGGDL + MT   D S++   FYA ELV+A++ LH MG+IHRD+KPDNML+ K+GH+KLADFGTC+R   NG VK    VGTPDYI PE+L   G   +  G E DWWA GI +YE+  GETPF  +S    Y  I  + + L +P+D        + +   L+   +R+   G   IK HP+  N   +WNF  IR+   PVI E+ G+DD ++   D   +  + +  F     F+G  L F GFT+         A+  G  + I+  I N +     ++ T L++  ++++ QL  +      EL   Q ++ D  R+L    + +N  K +   S++   ++KAK+E   K +E   R+I +L           +  + +   L  +++S       L + L K++EE      QID +  +NS   E   + Q   NE N K       EL+ EL  +R ++  L     + + + ++      + +   E+R   + ++ DL +  ++   L  DL  E  ++    S+L  + D+LS    N +  +   +N L  A D+KR +  ++  + S     + Q+E  ++ F+   S V + K E++ +    E  E+    ++ +    ++   T  M   +E++RL   + E N    D +  ++E E   L    Q+ + +L  K   I  +++++  L   L   Q EL+S                        +K+   + + K++E+M   ++   L   K          +KI +LE +L  E+ K++E+    +KE    K      +   ++L+ +LE               ++ +I  D        LM+ +N N++    + S  L++K  +                     W   FAV  P  L  Y  +ND  PF +I   ++ H R  SAA+     +N LP+I QI+Y                 + N   + S++      S +R   +  A  N       H  V + F   T CDLC +  S+ L PPPA EC  C+ R H++HL  G   I  C   ++    L    S E   AW+  L    +Y+
Sbjct:   40 RRTKNIDNFVTRYSEAVQQLTALRLKGSDFQLIKVIGRGAYGEVQLVRHNTSQNVYAMKLLNKNEMVRRADSAFFWEERDIMAHAHSEWIVRLHYAFQDTQFLYMVMEYMPGGDLVNLMTSY-DVSEKWARFYAAELVMALDTLHGMGYIHRDVKPDNMLISKSGHVKLADFGTCLRMGPNGLVKCTTAVGTPDYISPEVLELQGTEGV-YGREVDWWAVGIFVYEMLVGETPFYADSLMGTYTRIRNHATELNFPEDVEMSENAKNLVCAFLSSSEKRLGKEGVESIKQHPFFQND--EWNFDTIRKAVPPVIPELKGDDDASHFD-DIEAKEPDPAEFFQIPKSFAGNQLPFVGFTY---------ANETGPISIIQKKIENTSRGDAMQVRTALNQLNQISESQLEDEKRELEKELAAYQIQVKDLARKLDMEREEMNI-KIKMIISLEEQLIIKAKVEERVKELE---RQIGELNEKCRHHAEAEERARKQQSELHTKLNSQNEIARELNERLQKSNEEEAMLQQQIDQLHALNSQERENLRRAQQRSNEQNEKVE-----ELRTELAVARDREMALKCQMGKLSELMAQQENFSDENRVNDEARKNNVRLVGDLQAAHKKIEQLTSDLEQETNRRISTQSDLRCMNDQLS----NMQTSLHYQENELKRARDEKRRMEDQLQGLSSLSRLLQRQLEDVREQFDTESSFVNIYKTEMNAL--NEELLEKTRRLEQLEEHQRREEERTRDMLAHLESERLARRIAEENLSTTDKEKTMLEVEVRQLV---QRHEKELAAKDAAIQLISQKEEELQQSLQGAQNELRSISERDSSRTSPEESIRDLKNQLEHEKVMKITAINKLEEVMAQRQANEALKKGKVSRSDARRREKKIVELEKNLRMERQKYEERVMQIVKENEQLKLALAEEEKANEKLRMDLETFQHLEAAMNEQKKRERQDIHADQSRTSATNLMQQINENELRYDGAVSIRLTVKRRQ--------------------QWQECFAVFSPAGLFFYLTQNDRQPFQTIQADNLCHARHVSAADVRCAGENQLPRIFQILY---------------GTEENSSSRRSSMADLSSLSGSREEKLDKALWN------RHDLVELTFHMPTNCDLCVKPLSNLLRPPPAFECRRCRMRFHRDHL--GVETIPQCRQTVDAREMLIMAPSAETCEAWVQHLKRFLDYK 1188
[Close]
BLAST of Rho-associated kinase vs. TrEMBL
Match: A0A0K0JJA5 (BMA-LET-502 OS=Brugia malayi OX=6279 GN=bma-let-502 PE=4 SV=4)

HSP 1 Score: 395.201 bits (1014), Expect = 2.597e-113
Identity = 349/1231 (28.35%), Postives = 587/1231 (47.68%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNI---SNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRL--ISMMNDLSS----MEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLN-------QRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLK--LIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQS------------------------DKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIR---KIRQLETDLSKEKVKFQEK----LKECNDTKNECQTWQDQCKELKSELED-------KNNIIKDLMKSLNNDMIPKESPSDEL-SIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI--FLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPNTYYRSVRVPGRHS 3786
            + +K I  F+ R+S   +++  LR+  SDF +IK +G+G +G V LVRH  ++NVYAMK+++K+  V  + + F WEERDIMA   S+W+++  Y F D + LY+VMEYMPGGDL + MT   D S++   FYA ELV+A++ LH MG+IHRD+KPDNML+ K+GH+KLADFGTC+R   NG VK    VGTPDYI PE+L   G   +  G E DWWA GI +YE+  GETPF  +S    Y  I  + + L +P+D        + +   L+   +R+   G   IK HP+  N   +WNF  IR+   PVI E+ G+DD ++   D   +  + +  F     F+G  L F GFT++       +   K ++T  +  +   + L +L  ++SE++L  ++  L+      EL   Q ++ D  R+L    + +N  K +  +S++   ++KAK+E+  K +E   R+I +L           +  + +   L  +++S       L + L K++EE      QID +  +NS   E   + Q   NE N K       EL++EL ++R ++  L     + + + ++      + K   E+R   + ++ DL +    +E+  + L+ + N     ++++  + D+LS    N +  +   +N L    D+KR L            +++ + + + +Q     S V + K E++ +    E  E+    ++ +    ++   T  M   +E++RL   + E N    D +  ++E E   L    Q+ + +L  K   I  +++++  L   L   Q EL+S                        +K+   + + K++E+M   ++   L   KK + + ND+ R   KI +LE DL  E+ K++E+    +KE    K      +   ++L+ +LE         N   K   + ++ D  P+ S ++ +  I +NE++        L   + +    W   FA+  P  L  Y  +ND  PF +I    + H R  SAA+     +N LP+I QI+Y                 + N   + S++      S +R   +  A  N       H  V + F   T CDLC +  S+ L PPPA EC  C+ R H++HL  G   I  C   ++    L    S E   AW+  L    +Y+   ++         S++VP + +
Sbjct:   40 RRTKNIDNFVTRYSEAVQQLTTLRLKGSDFQLIKVIGRGAYGEVQLVRHTISRNVYAMKLLNKNEMVRRADSAFFWEERDIMAHAHSEWIVRLHYAFQDTQFLYMVMEYMPGGDLVNLMTSY-DVSEKWARFYAAELVMALDTLHGMGYIHRDVKPDNMLISKSGHVKLADFGTCLRMGPNGLVKCTTAVGTPDYISPEVLELQGTEGV-YGREVDWWAVGIFVYEMLVGETPFYADSLMGTYTRIRNHATELNFPEDVEMSENAKNLVRAFLSVSEKRLGKDGVESIKQHPFFQND--EWNFETIRKAVPPVIPELKGDDDASHFD-DIEVKEPDPAEFFQIPKSFAGNQLPFVGFTYSNETGPISVIQKKFETTSRDDAVQVRAALNQL-NQISESQLEDEKRKLE-----KELATYQIQVKDLARKLDMEREEMNI-KIKMITSLEEQLIIKAKVEDRMKELE---RQIGELNEKCRHHSEAEERARKQQSELHAKLNSQNEIARELNERLQKSNEEETVLQQQIDQLHALNSQERENLRRAQQRSNEQNEKVE-----ELRIELAAARDREMALKCQVGKLSELMAQQENFSDENKINDEARKNNVRLVGDLQAAHKKLEQLTSHLEQETNRRISAQNDVHCLNDQLS----NMQSSLHYQENELKRVRDEKRRLEDQLQSLSSLSRLLQRQLEDVREQFDTESSFVNIYKTEMNAL--NEELLEKTRRLEQLEEHQRREEERTRDMLAHLESERLARRIAEENLSTTDKEKTMLEVEVRQLV---QRHEKELAAKDAAIQLISQKEEELQQSLQGAQNELRSISERDWSRTSPEESIRDLKNQLEHEKVMKTTAINKLEEVMAQRQANEAL---KKGKMSRNDARRREKKIVELEKDLRMERQKYEERVMQIVKENEQLKLALAEEEKANEKLRMDLETFRHLETAMNEQKKRERQEIHGDH-PRTSATNLMQGINENELRYDGAVSIRLTVKRRQ---QWQECFAIFNPAGLFFYLTQNDRQPFQTIQADRLCHARHVSAADVRCAGENQLPRIFQILY---------------GTEENSSSRRSSVADLSSLSGSREEKLDKALWN------RHDLVELTFHMPTNCDLCVKPLSNLLRPPPAFECRRCRMRFHRDHL--GVETIPQCRQTVDAREMLIMAPSAETCEAWVQHLKRFLDYKHSQKMGTLLPLSGSSMKVPTKSA 1211
[Close]
BLAST of Rho-associated kinase vs. TrEMBL
Match: A0A4E9FNU6 (Uncharacterized protein OS=Brugia malayi OX=6279 GN=Bma-let-502 PE=4 SV=1)

HSP 1 Score: 395.201 bits (1014), Expect = 2.597e-113
Identity = 349/1231 (28.35%), Postives = 587/1231 (47.68%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNI---SNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRL--ISMMNDLSS----MEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLN-------QRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLK--LIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQS------------------------DKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIR---KIRQLETDLSKEKVKFQEK----LKECNDTKNECQTWQDQCKELKSELED-------KNNIIKDLMKSLNNDMIPKESPSDEL-SIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI--FLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPNTYYRSVRVPGRHS 3786
            + +K I  F+ R+S   +++  LR+  SDF +IK +G+G +G V LVRH  ++NVYAMK+++K+  V  + + F WEERDIMA   S+W+++  Y F D + LY+VMEYMPGGDL + MT   D S++   FYA ELV+A++ LH MG+IHRD+KPDNML+ K+GH+KLADFGTC+R   NG VK    VGTPDYI PE+L   G   +  G E DWWA GI +YE+  GETPF  +S    Y  I  + + L +P+D        + +   L+   +R+   G   IK HP+  N   +WNF  IR+   PVI E+ G+DD ++   D   +  + +  F     F+G  L F GFT++       +   K ++T  +  +   + L +L  ++SE++L  ++  L+      EL   Q ++ D  R+L    + +N  K +  +S++   ++KAK+E+  K +E   R+I +L           +  + +   L  +++S       L + L K++EE      QID +  +NS   E   + Q   NE N K       EL++EL ++R ++  L     + + + ++      + K   E+R   + ++ DL +    +E+  + L+ + N     ++++  + D+LS    N +  +   +N L    D+KR L            +++ + + + +Q     S V + K E++ +    E  E+    ++ +    ++   T  M   +E++RL   + E N    D +  ++E E   L    Q+ + +L  K   I  +++++  L   L   Q EL+S                        +K+   + + K++E+M   ++   L   KK + + ND+ R   KI +LE DL  E+ K++E+    +KE    K      +   ++L+ +LE         N   K   + ++ D  P+ S ++ +  I +NE++        L   + +    W   FA+  P  L  Y  +ND  PF +I    + H R  SAA+     +N LP+I QI+Y                 + N   + S++      S +R   +  A  N       H  V + F   T CDLC +  S+ L PPPA EC  C+ R H++HL  G   I  C   ++    L    S E   AW+  L    +Y+   ++         S++VP + +
Sbjct:   40 RRTKNIDNFVTRYSEAVQQLTTLRLKGSDFQLIKVIGRGAYGEVQLVRHTISRNVYAMKLLNKNEMVRRADSAFFWEERDIMAHAHSEWIVRLHYAFQDTQFLYMVMEYMPGGDLVNLMTSY-DVSEKWARFYAAELVMALDTLHGMGYIHRDVKPDNMLISKSGHVKLADFGTCLRMGPNGLVKCTTAVGTPDYISPEVLELQGTEGV-YGREVDWWAVGIFVYEMLVGETPFYADSLMGTYTRIRNHATELNFPEDVEMSENAKNLVRAFLSVSEKRLGKDGVESIKQHPFFQND--EWNFETIRKAVPPVIPELKGDDDASHFD-DIEVKEPDPAEFFQIPKSFAGNQLPFVGFTYSNETGPISVIQKKFETTSRDDAVQVRAALNQL-NQISESQLEDEKRKLE-----KELATYQIQVKDLARKLDMEREEMNI-KIKMITSLEEQLIIKAKVEDRMKELE---RQIGELNEKCRHHSEAEERARKQQSELHAKLNSQNEIARELNERLQKSNEEETVLQQQIDQLHALNSQERENLRRAQQRSNEQNEKVE-----ELRIELAAARDREMALKCQVGKLSELMAQQENFSDENKINDEARKNNVRLVGDLQAAHKKLEQLTSHLEQETNRRISAQNDVHCLNDQLS----NMQSSLHYQENELKRVRDEKRRLEDQLQSLSSLSRLLQRQLEDVREQFDTESSFVNIYKTEMNAL--NEELLEKTRRLEQLEEHQRREEERTRDMLAHLESERLARRIAEENLSTTDKEKTMLEVEVRQLV---QRHEKELAAKDAAIQLISQKEEELQQSLQGAQNELRSISERDWSRTSPEESIRDLKNQLEHEKVMKTTAINKLEEVMAQRQANEAL---KKGKMSRNDARRREKKIVELEKDLRMERQKYEERVMQIVKENEQLKLALAEEEKANEKLRMDLETFRHLETAMNEQKKRERQEIHGDH-PRTSATNLMQGINENELRYDGAVSIRLTVKRRQ---QWQECFAIFNPAGLFFYLTQNDRQPFQTIQADRLCHARHVSAADVRCAGENQLPRIFQILY---------------GTEENSSSRRSSVADLSSLSGSREEKLDKALWN------RHDLVELTFHMPTNCDLCVKPLSNLLRPPPAFECRRCRMRFHRDHL--GVETIPQCRQTVDAREMLIMAPSAETCEAWVQHLKRFLDYKHSQKMGTLLPLSGSSMKVPTKSA 1211
[Close]
BLAST of Rho-associated kinase vs. Ensembl Cavefish
Match: rock2a (rho-associated protein kinase 2 [Source:NCBI gene;Acc:103042784])

HSP 1 Score: 319.701 bits (818), Expect = 1.540e-89
Identity = 289/982 (29.43%), Postives = 479/982 (48.78%), Query Frame = 1 
Query:  169 NKLSLIENEIFNPXXXXXXXXXXXXXXXISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNR----FNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQN--LINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLKL--IEYENGSLCMINQKMKIDLEEKK--QQIMDMTKEKMVLTNDLD----KVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDN--DSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQ----TWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSI 3039
            N+L  +E  I +P S + L++LLD  +++  D+      KN K I+ FL+R+      I +L++   DF  +K +G+G FG V LVRH++++ VYAMK++ K   +  S + F WEERDIMA   S W+++    F D + LY+VMEYMPGGDL + +T   D  ++   FY  E+V+A++ +H+MGFIHRD+KPDNMLLD+NGH+KLADFGTC++    G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ I+E+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IKSHP+  N   +W F  IR+  +PV+ E+S + DT+   +D  +        F     F G  L F GFT+ +      + N  A    K          L  LE +L+    AK +L  K   T+  L K  K+L          E+ IN+ K+                      +ESS R++E+ K+++  K                             ++  KA  E + K    + +  +    EE K +NQN  + NE N         +LQ +L  +    N LL +   +A    +      K+ Q LE+ +  + +    +E  K AL+ D  +       L+   D  +++ T +   +S LQ R ++ ED+ + + Q +   ESEK Q+  Q+K+ +   E    E+D        Q+    E+        +  + + ++ S+E  + +A + E+  KL++ +   +  EN  L +  Q   +D + K+  Q++ ++ + K  LT ++     ++++E+Q   L    L  +  ++ T   S  QL     K++ ++  D  R + +  T+L KE+     ++KE  D     Q     ++ Q +ELK E E++N + KD+ ++L      ++S + +L I
Sbjct:   11 NRLKKLEAMIRDPRSAINLESLLDAVNALVLDLDFPALRKN-KNIETFLNRYEKVMNHIRELQMKPEDFDRVKVIGRGAFGEVQLVRHRASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFADSPWVVQLCCAFQDDRYLYMVMEYMPGGDLVN-LTSTYDVPEKWAKFYTAEVVMALDAIHSMGFIHRDVKPDNMLLDRNGHLKLADFGTCMKMDSTGMVHCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFIFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISKEAKNIICAFLTDREVRLGRNGVGEIKSHPFFKND--QWTFDTIRDTAAPVVPELSSDIDTS--NFDEIEEDKGDVETFPTPKAFVGNQLPFVGFTYFKEDQLLTSSNSSAEHPTKGEDSVAIQKKLHCLEEQLNNEMQAKDELEHKYRTTSGRLDKITKEL----------EEEINSRKA----------------------LESSLRQLEREKALLQHK---------------------------SVESHRKAESEADRKRCLENEVNSLRDQLEEMKKRNQNSHISNEKN--------IQLQRQLDEA----NALLRAESDAATRLRKSQTESSKQLQQLETHVRELQDKCCLLESSKLALEKDYIS-------LQAALDTETREHTQRSETISDLQVRQSSLEDEVKQVRQALAKAESEKRQL--QEKLTDLEKEKSNKEIDMTYKLKVLQQSLEQEEGAHKATKARLADKSKISESIEGAKSEA-MKELEWKLQEERSSKLRVENRLLELEKQNSMLDCDYKQALQKLDELRRHKDRLTEEVKNLSLRIEQEMQKRSLTQNDLKVQNQQLSTLRTSEKQL-----KQEINHLLDIKRSLEKQNTELRKERQDSDGQMKELQDQLEAEQYFSTLYKTQVRELKEECEERNKLYKDMQQNLQELQEERDSLAAQLEI 899

HSP 2 Score: 70.0922 bits (170), Expect = 1.765e-11
Identity = 93/399 (23.31%), Postives = 162/399 (40.60%), Query Frame = 1 
Query: 2680 QKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKI---RQLETDLSKEKVKFQEKL----KECNDTKNECQTWQDQCKELKSELEDKNNII---KDLMKSLNNDMIPKESPSD--ELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL---NSLKEYQKKAEIQIAPNTYYR-----SVRVPGRHSPA 3792
            +K+LQS++      V K+ E+M N K +    SR+     D D  RK    R+L+ +L  EK K    +    +E ND + +         EL+  L+ K++ I   + L+ SLN   +   S S   +    ++  ++       L       +  W   + V+   K+  Y  E D   + P+  +D+  + H+R  +  +    D   +P+I QI+Y   + G+  + Q +             L + +     +SS I           + H F+P  +   T C+ C +   +   PPPALEC  C  + H++H+   E  I  C    ++      L    S+E +  W+S L      K    +A  + +P    +     S+R P R  PA
Sbjct: 1003 EKQLQSERTLKTQAVNKLAEIM-NRKEVRGGGSRRG---NDTDVKRKEKENRKLQLELRSEKEKLNSTIIKYQREINDMQAQLADESVVRVELQMALDSKDSDIEQLRGLLNSLNVHSLDSASMSSGPDFETDESLPETRLEGWLSLPVRNNTKRFGWERKYVVVSSKKILFYNSEQDKEHSNPYMVLDIDKLFHVRSVTQTDVYRADAKEIPRIFQILY--ANEGESKKEQEL-----------EPLPIGE-----KSSYICH---------KGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEVIAPCKVNYDVSTAKNLLLLAASQEEQQKWVSRLVKKIPKKPPVPEATHRSSPRVPVKVQASQSLRRPSRQLPA 1370
[Close]
BLAST of Rho-associated kinase vs. Ensembl Cavefish
Match: rock2a (rho-associated protein kinase 2 [Source:NCBI gene;Acc:103042784])

HSP 1 Score: 318.931 bits (816), Expect = 1.694e-89
Identity = 290/984 (29.47%), Postives = 483/984 (49.09%), Query Frame = 1 
Query:  169 NKLSLIENEIFNPXXXXXXXXXXXXXXXISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKS---TGIEGNIS---NLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQN--LINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLKL--IEYENGSLCMINQKMKIDLEEKK--QQIMDMTKEKMVLTNDLD----KVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDN--DSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQ----TWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSI 3039
            N+L  +E  I +P S + L++LLD  +++  D+      KN K I+ FL+R+      I +L++   DF  +K +G+G FG V LVRH++++ VYAMK++ K   +  S + F WEERDIMA   S W+++    F D + LY+VMEYMPGGDL + +T   D  ++   FY  E+V+A++ +H+MGFIHRD+KPDNMLLD+NGH+KLADFGTC++    G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ I+E+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IKSHP+  N   +W F  IR+  +PV+ E+S + DT+   +D  +        F     F G  L F GFT+  F     L  +   +   T  E +++    L  LE +L+    AK +L  K   T+  L K  K+L          E+ IN+ K+                      +ESS R++E+ K+++  K                             ++  KA  E + K    + +  +    EE K +NQN  + NE N         +LQ +L  +    N LL +   +A    +      K+ Q LE+ +  + +    +E  K AL+ D  +       L+   D  +++ T +   +S LQ R ++ ED+ + + Q +   ESEK Q+  Q+K+ +   E    E+D        Q+    E+        +  + + ++ S+E  + +A + E+  KL++ +   +  EN  L +  Q   +D + K+  Q++ ++ + K  LT ++     ++++E+Q   L    L  +  ++ T   S  QL     K++ ++  D  R + +  T+L KE+     ++KE  D     Q     ++ Q +ELK E E++N + KD+ ++L      ++S + +L I
Sbjct:   11 NRLKKLEAMIRDPRSAINLESLLDAVNALVLDLDFPALRKN-KNIETFLNRYEKVMNHIRELQMKPEDFDRVKVIGRGAFGEVQLVRHRASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFADSPWVVQLCCAFQDDRYLYMVMEYMPGGDLVN-LTSTYDVPEKWAKFYTAEVVMALDAIHSMGFIHRDVKPDNMLLDRNGHLKLADFGTCMKMDSTGMVHCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFIFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISKEAKNIICAFLTDREVRLGRNGVGEIKSHPFFKND--QWTFDTIRDTAAPVVPELSSDIDTS--NFDEIEEDKGDVETFPTPKAFVGNQLPFVGFTY--FKEDQLLTSSNSSAEHPTKGEDSVAIQKKLHCLEEQLNNEMQAKDELEHKYRTTSGRLDKITKEL----------EEEINSRKA----------------------LESSLRQLEREKALLQHK---------------------------SVESHRKAESEADRKRCLENEVNSLRDQLEEMKKRNQNSHISNEKN--------IQLQRQLDEA----NALLRAESDAATRLRKSQTESSKQLQQLETHVRELQDKCCLLESSKLALEKDYIS-------LQAALDTETREHTQRSETISDLQVRQSSLEDEVKQVRQALAKAESEKRQL--QEKLTDLEKEKSNKEIDMTYKLKVLQQSLEQEEGAHKATKARLADKSKISESIEGAKSEA-MKELEWKLQEERSSKLRVENRLLELEKQNSMLDCDYKQALQKLDELRRHKDRLTEEVKNLSLRIEQEMQKRSLTQNDLKVQNQQLSTLRTSEKQL-----KQEINHLLDIKRSLEKQNTELRKERQDSDGQMKELQDQLEAEQYFSTLYKTQVRELKEECEERNKLYKDMQQNLQELQEERDSLAAQLEI 899

HSP 2 Score: 70.8626 bits (172), Expect = 9.139e-12
Identity = 93/399 (23.31%), Postives = 162/399 (40.60%), Query Frame = 1 
Query: 2680 QKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKI---RQLETDLSKEKVKFQEKL----KECNDTKNECQTWQDQCKELKSELEDKNNII---KDLMKSLNNDMIPKESPSD--ELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL---NSLKEYQKKAEIQIAPNTYYR-----SVRVPGRHSPA 3792
            +K+LQS++      V K+ E+M N K +    SR+     D D  RK    R+L+ +L  EK K    +    +E ND + +         EL+  L+ K++ I   + L+ SLN   +   S S   +    ++  ++       L       +  W   + V+   K+  Y  E D   + P+  +D+  + H+R  +  +    D   +P+I QI+Y   + G+  + Q +             L + +     +SS I           + H F+P  +   T C+ C +   +   PPPALEC  C  + H++H+   E  I  C    ++      L    S+E +  W+S L      K    +A  + +P    +     S+R P R  PA
Sbjct: 1003 EKQLQSERTLKTQAVNKLAEIM-NRKEVRGGGSRRG---NDTDVKRKEKENRKLQLELRSEKEKLNSTIIKYQREINDMQAQLADESVVRVELQMALDSKDSDIEQLRGLLNSLNVHSLDSASMSSGPDFETDESLPETRLEGWLSLPVRNNTKRFGWERKYVVVSSKKILFYNSEQDKEHSNPYMVLDIDKLFHVRSVTQTDVYRADAKEIPRIFQILY--ANEGESKKEQEL-----------EPLPIGE-----KSSYICH---------KGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEVIAPCKVNYDVSTAKNLLLLAASQEEQQKWVSRLVKKIPKKPPVPEATHRSSPRVPVKVQASQSLRRPSRQLPA 1370
[Close]
BLAST of Rho-associated kinase vs. Ensembl Cavefish
Match: rock2a (rho-associated protein kinase 2 [Source:NCBI gene;Acc:103042784])

HSP 1 Score: 310.457 bits (794), Expect = 1.533e-86
Identity = 272/922 (29.50%), Postives = 450/922 (48.81%), Query Frame = 1 
Query:  343 IYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKST-GIEGNIS-NLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQN--LINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLKL--IEYENGSLCMINQKMKIDLEEKK--QQIMDMTKEKMVLTNDLD----KVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDN--DSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQ----TWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSI 3039
            I +L++   DF  +K +G+G FG V LVRH++++ VYAMK++ K   +  S + F WEERDIMA   S W+++    F D + LY+VMEYMPGGDL + +T   D  ++   FY  E+V+A++ +H+MGFIHRD+KPDNMLLD+NGH+KLADFGTC++    G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ I+E+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IKSHP+  N   +W F  IR+  +PV+ E+S + DT+   +D  +        F     F G  L F GFT+  F     L  +   +    +G I   L  LE +L+    AK +L  K   T+  L K  K+L          E+ IN+ K+                      +ESS R++E+ K+++  K                             ++  KA  E + K    + +  +    EE K +NQN  + NE N         +LQ +L  +    N LL +   +A    +      K+ Q LE+ +  + +    +E  K AL+ D  +       L+   D  +++ T +   +S LQ R ++ ED+ + + Q +   ESEK Q+  Q+K+ +   E    E+D        Q+    E+        +  + + ++ S+E  + +A + E+  KL++ +   +  EN  L +  Q   +D + K+  Q++ ++ + K  LT ++     ++++E+Q   L    L  +  ++ T   S  QL     K++ ++  D  R + +  T+L KE+     ++KE  D     Q     ++ Q +ELK E E++N + KD+ ++L      ++S + +L I
Sbjct:    4 IRELQMKPEDFDRVKVIGRGAFGEVQLVRHRASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFADSPWVVQLCCAFQDDRYLYMVMEYMPGGDLVN-LTSTYDVPEKWAKFYTAEVVMALDAIHSMGFIHRDVKPDNMLLDRNGHLKLADFGTCMKMDSTGMVHCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFIFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISKEAKNIICAFLTDREVRLGRNGVGEIKSHPFFKND--QWTFDTIRDTAAPVVPELSSDIDTS--NFDEIEEDKGDVETFPTPKAFVGNQLPFVGFTY--FKEDQLLTSSNSSAEHPTKGEIQKKLHCLEEQLNNEMQAKDELEHKYRTTSGRLDKITKEL----------EEEINSRKA----------------------LESSLRQLEREKALLQHK---------------------------SVESHRKAESEADRKRCLENEVNSLRDQLEEMKKRNQNSHISNEKN--------IQLQRQLDEA----NALLRAESDAATRLRKSQTESSKQLQQLETHVRELQDKCCLLESSKLALEKDYIS-------LQAALDTETREHTQRSETISDLQVRQSSLEDEVKQVRQALAKAESEKRQL--QEKLTDLEKEKSNKEIDMTYKLKVLQQSLEQEEGAHKATKARLADKSKISESIEGAKSEA-MKELEWKLQEERSSKLRVENRLLELEKQNSMLDCDYKQALQKLDELRRHKDRLTEEVKNLSLRIEQEMQKRSLTQNDLKVQNQQLSTLRTSEKQL-----KQEINHLLDIKRSLEKQNTELRKERQDSDGQMKELQDQLEAEQYFSTLYKTQVRELKEECEERNKLYKDMQQNLQELQEERDSLAAQLEI 831

HSP 2 Score: 69.707 bits (169), Expect = 2.032e-11
Identity = 93/399 (23.31%), Postives = 162/399 (40.60%), Query Frame = 1 
Query: 2680 QKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKI---RQLETDLSKEKVKFQEKL----KECNDTKNECQTWQDQCKELKSELEDKNNII---KDLMKSLNNDMIPKESPSD--ELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL---NSLKEYQKKAEIQIAPNTYYR-----SVRVPGRHSPA 3792
            +K+LQS++      V K+ E+M N K +    SR+     D D  RK    R+L+ +L  EK K    +    +E ND + +         EL+  L+ K++ I   + L+ SLN   +   S S   +    ++  ++       L       +  W   + V+   K+  Y  E D   + P+  +D+  + H+R  +  +    D   +P+I QI+Y   + G+  + Q +             L + +     +SS I           + H F+P  +   T C+ C +   +   PPPALEC  C  + H++H+   E  I  C    ++      L    S+E +  W+S L      K    +A  + +P    +     S+R P R  PA
Sbjct:  935 EKQLQSERTLKTQAVNKLAEIM-NRKEVRGGGSRRG---NDTDVKRKEKENRKLQLELRSEKEKLNSTIIKYQREINDMQAQLADESVVRVELQMALDSKDSDIEQLRGLLNSLNVHSLDSASMSSGPDFETDESLPETRLEGWLSLPVRNNTKRFGWERKYVVVSSKKILFYNSEQDKEHSNPYMVLDIDKLFHVRSVTQTDVYRADAKEIPRIFQILY--ANEGESKKEQEL-----------EPLPIGE-----KSSYICH---------KGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEVIAPCKVNYDVSTAKNLLLLAASQEEQQKWVSRLVKKIPKKPPVPEATHRSSPRVPVKVQASQSLRRPSRQLPA 1302
[Close]
BLAST of Rho-associated kinase vs. Ensembl Cavefish
Match: rock2a (rho-associated protein kinase 2 [Source:NCBI gene;Acc:103042784])

HSP 1 Score: 309.301 bits (791), Expect = 2.404e-86
Identity = 271/924 (29.33%), Postives = 448/924 (48.48%), Query Frame = 1 
Query:  343 IYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNR----FNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQN--LINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLKL--IEYENGSLCMINQKMKIDLEEKK--QQIMDMTKEKMVLTNDLD----KVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDN--DSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQ----TWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSI 3039
            I +L++   DF  +K +G+G FG V LVRH++++ VYAMK++ K   +  S + F WEERDIMA   S W+++    F D + LY+VMEYMPGGDL + +T   D  ++   FY  E+V+A++ +H+MGFIHRD+KPDNMLLD+NGH+KLADFGTC++    G V  +  VGTPDYI PE+L++ G  D   G E DWW+ G+ I+E+  G+TPF  +S    Y  IM +K++L +PDD     E  + +   LT+   R+   G   IKSHP+  N   +W F  IR+  +PV+ E+S + DT+   +D  +        F     F G  L F GFT+ +      + N  A    K          L  LE +L+    AK +L  K   T+  L K  K+L          E+ IN+ K+                      +ESS R++E+ K+++  K                             ++  KA  E + K    + +  +    EE K +NQN  + NE N         +LQ +L  +    N LL +   +A    +      K+ Q LE+ +  + +    +E  K AL+ D  +       L+   D  +++ T +   +S LQ R ++ ED+ + + Q +   ESEK Q+  Q+K+ +   E    E+D        Q+    E+        +  + + ++ S+E  + +A + E+  KL++ +   +  EN  L +  Q   +D + K+  Q++ ++ + K  LT ++     ++++E+Q   L    L  +  ++ T   S  QL     K++ ++  D  R + +  T+L KE+     ++KE  D     Q     ++ Q +ELK E E++N + KD+ ++L      ++S + +L I
Sbjct:    4 IRELQMKPEDFDRVKVIGRGAFGEVQLVRHRASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFADSPWVVQLCCAFQDDRYLYMVMEYMPGGDLVN-LTSTYDVPEKWAKFYTAEVVMALDAIHSMGFIHRDVKPDNMLLDRNGHLKLADFGTCMKMDSTGMVHCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFIFEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISKEAKNIICAFLTDREVRLGRNGVGEIKSHPFFKND--QWTFDTIRDTAAPVVPELSSDIDTS--NFDEIEEDKGDVETFPTPKAFVGNQLPFVGFTYFKEDQLLTSSNSSAEHPTKGEDSVAIQKKLHCLEEQLNNEMQAKDELEHKYRTTSGRLDKITKEL----------EEEINSRKA----------------------LESSLRQLEREKALLQHK---------------------------SVESHRKAESEADRKRCLENEVNSLRDQLEEMKKRNQNSHISNEKN--------IQLQRQLDEA----NALLRAESDAATRLRKSQTESSKQLQQLETHVRELQDKCCLLESSKLALEKDYIS-------LQAALDTETREHTQRSETISDLQVRQSSLEDEVKQVRQALAKAESEKRQL--QEKLTDLEKEKSNKEIDMTYKLKVLQQSLEQEEGAHKATKARLADKSKISESIEGAKSEA-MKELEWKLQEERSSKLRVENRLLELEKQNSMLDCDYKQALQKLDELRRHKDRLTEEVKNLSLRIEQEMQKRSLTQNDLKVQNQQLSTLRTSEKQL-----KQEINHLLDIKRSLEKQNTELRKERQDSDGQMKELQDQLEAEQYFSTLYKTQVRELKEECEERNKLYKDMQQNLQELQEERDSLAAQLEI 835

HSP 2 Score: 70.8626 bits (172), Expect = 8.548e-12
Identity = 93/399 (23.31%), Postives = 162/399 (40.60%), Query Frame = 1 
Query: 2680 QKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKI---RQLETDLSKEKVKFQEKL----KECNDTKNECQTWQDQCKELKSELEDKNNII---KDLMKSLNNDMIPKESPSD--ELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL---NSLKEYQKKAEIQIAPNTYYR-----SVRVPGRHSPA 3792
            +K+LQS++      V K+ E+M N K +    SR+     D D  RK    R+L+ +L  EK K    +    +E ND + +         EL+  L+ K++ I   + L+ SLN   +   S S   +    ++  ++       L       +  W   + V+   K+  Y  E D   + P+  +D+  + H+R  +  +    D   +P+I QI+Y   + G+  + Q +             L + +     +SS I           + H F+P  +   T C+ C +   +   PPPALEC  C  + H++H+   E  I  C    ++      L    S+E +  W+S L      K    +A  + +P    +     S+R P R  PA
Sbjct:  939 EKQLQSERTLKTQAVNKLAEIM-NRKEVRGGGSRRG---NDTDVKRKEKENRKLQLELRSEKEKLNSTIIKYQREINDMQAQLADESVVRVELQMALDSKDSDIEQLRGLLNSLNVHSLDSASMSSGPDFETDESLPETRLEGWLSLPVRNNTKRFGWERKYVVVSSKKILFYNSEQDKEHSNPYMVLDIDKLFHVRSVTQTDVYRADAKEIPRIFQILY--ANEGESKKEQEL-----------EPLPIGE-----KSSYICH---------KGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEVIAPCKVNYDVSTAKNLLLLAASQEEQQKWVSRLVKKIPKKPPVPEATHRSSPRVPVKVQASQSLRRPSRQLPA 1306
[Close]
BLAST of Rho-associated kinase vs. Ensembl Cavefish
Match: ROCK1 (Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251])

HSP 1 Score: 287.345 bits (734), Expect = 3.707e-86
Identity = 159/378 (42.06%), Postives = 224/378 (59.26%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNF 1371
            + YD+      KN K I  FL R      KI  LR+   D+ V+K +G+G FG V LVRHK+T+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H MGFIHRD+KPDNMLLDK+GH+KLADFGTC++  K+G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K+ L +P+D     +    +   LT+   R+   G   IK H +  N   +W + +IR+  +PV+ E+S + DT+   +D  +        F     F G  L F GFT+   N   F
Sbjct:   22 LVYDLDFPALRKN-KSIDNFLSRCE--CVKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSSWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDGIHAMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFPEDSDISKDAKSLICAFLTDREVRLGRNGVDEIKRHSFFKND--QWTWDNIRDTAAPVVPELSSDIDTS--NFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTYYSGNQTKF 390
[Close]
BLAST of Rho-associated kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003561.1 (pep scaffold:Pmarinus_7.0:GL478057:5187:43749:1 gene:ENSPMAG00000003167.1 transcript:ENSPMAT00000003561.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 312.383 bits (799), Expect = 5.424e-88
Identity = 170/430 (39.53%), Postives = 247/430 (57.44%), Query Frame = 1 
Query:  295 KPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKN-GKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNF-----------LAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSD 1536
            K I  FL+R+     K+  LR+  +D+ V+K +G+G FG V LVRHK+TK VYAMK++ K      S + F WEERDIMA  +S W+++ FY F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDKNGH+KLADFGTC++    G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ +YE+  G+TPF  +S    Y  IM +K+ L +PDD     +  + +   L +   R+   G   IK HP+  N   +W + +IRE  +PV+ E+  + DT+   +D  +        F     FSG  L F GFT+  ++ Y             L +   +S+ ++     + +LE +L     AK ++  K  NT   L K  K+L +
Sbjct:   50 KNIDNFLNRYEKAVGKVRDLRMRANDYDVVKVIGRGAFGEVQLVRHKATKKVYAMKLLSKFEMTKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDHRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKNGHLKLADFGTCMKMDTEGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNALNFPDDVDISKDAKNLICAFLIDREVRVGRNGVGEIKRHPFFKND--QWTWENIRETAAPVVPELVSDTDTS--NFDEIEEDKAEDETFPVPKAFSGNQLPFVGFTY--YSDYQLFSVNGTEVNRALMNQPRQSSVVDKLHQKVYQLEEQLHNEMQAKDEMEQKYRNTNIRLEKIMKELDE 471

HSP 2 Score: 64.6994 bits (156), Expect = 1.352e-10
Identity = 46/213 (21.60%), Postives = 82/213 (38.50%), Query Frame = 1 
Query: 3112 SWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVEN---------HSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWC------PDAIEIFLFKVESKEAKNAWISCL 3696
             W   + V+   K+  Y  E D   + P+  +D+  + H+R  +  +    +   +P+I QI+Y                              ++G S  R  +    +P  P++ ++         H F+P  +    +C+ C +   +   PPPALEC  C  + H++HL   E  I  C        A +I L    S E +  W++ L
Sbjct: 1160 GWKKQYVVVSSKKILFYNDEQDKELSTPYMVLDIDKLFHVRPVTQGDVYRAEAKDIPRIFQILY-----------------------------ANEGES--RKELEFPLEPLAPLSEKDRDVCVPHKGHEFIPTIYHFPASCEACTKPLWNMFKPPPALECRRCHVKCHRDHLDRKEEVIAPCKVNFDVASAKDILLL-AGSPEDQKKWVNRL 1340
[Close]
BLAST of Rho-associated kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004595.1 (pep scaffold:Pmarinus_7.0:GL477044:11103:63873:-1 gene:ENSPMAG00000004137.1 transcript:ENSPMAT00000004595.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 311.227 bits (796), Expect = 1.347e-87
Identity = 218/662 (32.93%), Postives = 349/662 (52.72%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKG---------KSTGIE-GNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNR---EIEQLKSVIGEKENLLKSL-----KTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLIS-MMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLS 2199
            + +K +++FL R+     K+  LR+   D+  +K +G+G FG V LVRHK TK+VYAMK+++K   +  S + F WEERDIMA  +S W+++ FY+F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLAV+ +H+MG+IHRD+KPDNMLLDK+GH+KLADFGTC++  K+G V+ +  VGTPDYI PE+LR+ G      G E DWW+ G+ ++E+  G+TPF  ES    Y  IM +K +L +P D          +   LTE   R+   G   IK H +  N   +W + +IRE  +PV+ E+S + DT+   +D  +   +    F     F G  L F GFT+  +  +  L+             KS+ +E  +   +  LE ++  A   K +   K  N  + L K           LKD E+   + K+  E+ +   +  KA +++  K++E   R   E ++ + + GE  +L + L     K +N  +S+E       ++ L++ L  + EE+  +       KK+ +      +  ++   E+    RK+   +L LE      K+ + L S L S           ++  +   S LIS + + LSS++EE   L+  L+  ++++ +L+   DKLS
Sbjct:   18 RKNKNVESFLQRYGEAVGKVRDLRMRADDYDSVKVIGRGAFGEVQLVRHKVTKSVYAMKLLNKLEMIKRSDSAFFWEERDIMAFANSPWIVQLFYSFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLAVDAIHSMGYIHRDVKPDNMLLDKSGHLKLADFGTCMKLNKDGMVRCDTAVGTPDYISPEVLRSQGGQGY-YGRECDWWSVGVFLFEMLVGDTPFYAESLVGTYGKIMDHKKSLTFPVDLDISKNAKSLICAFLTERDVRLGKNGFAEIKCHDFFKND--QWTWENIRETSAPVVPELSSDTDTS--NFDEIENDKSADETFPQPKAFVGNQLPFVGFTY--YKDHQLLSGVPAVAGNNEEPLKSSQVEISHKMKIEMLERQMKNAVQVKDEAEQKCRNANSRLEKL----------LKDLEEECVSRKN-LEAQLRQMERDKALVQH--KMVEQQRRADAESDKKRHLDGEVNSLKEQLEELKKKNQNSQVSNE------KVTLLQKQLDDSLEELRSEREACSRAKKVQAEGARALAALEDANRELGEHVRKLEGEKLALE------KELIGLQSALDS-----------ERRDRTQGSELISDLQSRLSSLQEELKDLRSSLSRAEVERGQLQ---DKLS 632

HSP 2 Score: 59.6918 bits (143), Expect = 4.893e-9
Identity = 41/206 (19.90%), Postives = 77/206 (37.38%), Query Frame = 1 
Query: 3109 ISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDA--QPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL 3696
              W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    +   +P+I QI+Y                              ++G SS    ++ D+  +    +  + H  VP  +   T+C+ C++   +   PP ALEC  C  + H++H    E  +  C    ++      L    S   +  W+S L
Sbjct: 1124 FGWRKQYVVVSSKKILFYNAEADKEHSNPCMVLDIDKLFHVRPVTQGDAYRAEAKDIPKIFQILY-----------------------------ANEGESSKDQELVPDSMLEKQNCLVHKGHELVPTIYHFPTSCEACNRPLWNVFKPPAALECRRCHIKCHRDHFDRNEDFLAPCKLCFDVASAKNLLLLASSPSEQQKWVSHL 1300
[Close]
BLAST of Rho-associated kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006413.1 (pep scaffold:Pmarinus_7.0:GL485553:3974:11158:-1 gene:ENSPMAG00000005799.1 transcript:ENSPMAT00000006413.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 256.529 bits (654), Expect = 9.141e-77
Identity = 142/341 (41.64%), Postives = 204/341 (59.82%), Query Frame = 1 
Query:  340 KIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTF 1347
            K++ LR+++ DF ++K +G+G FG V LVRHK T+ V+AMK ++K   +  S + F WEERDIMA  +S W+I+ F  F D + LY+VMEYMPGGDL   M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLD+ GH+KLADFGTC++    G V++N  VGTPDYI PE+L++ G  D   G        G  +     G+TPF  ES    Y  IM ++++L +PDD     E    +   LT+   R+  TG   IK HP+  N   +W + +IRE  +PV+ E++ + D +    D +++       F     F G  L F GFT+
Sbjct:    6 KVHDLRMNVHDFELLKVIGRGAFGVVQLVRHKQTRRVHAMKRLNKGEMLKRSDSAFFWEERDIMAFANSSWIIQLFSAFQDERYLYMVMEYMPGGDLVSLMSNY-DVPEKWARFYTAEVVLALDAIHSMGFIHRDIKPDNMLLDRLGHLKLADFGTCMKMDAEGMVRSNTAVGTPDYISPEVLKSQG-GDGYYGLHEP-PEIGNHLVAAHAGDTPFYAESLVGTYSKIMDHRNSLCFPDDASVSKEARSLICAFLTDREVRLGRTGVDEIKRHPFFRND--QWTWQNIRETVAPVVPELASDADASCFD-DISEQEKAEEEAFSVPKAFLGNQLPFIGFTY 340
[Close]
BLAST of Rho-associated kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002084.1 (pep scaffold:Pmarinus_7.0:GL476486:6827:40506:-1 gene:ENSPMAG00000001890.1 transcript:ENSPMAT00000002084.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 259.225 bits (661), Expect = 4.818e-74
Identity = 175/554 (31.59%), Postives = 286/554 (51.62%), Query Frame = 1 
Query:  331 FSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNG-FWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDK-PAKPEFIDFMSKILTEPTERMDITGI---KSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFN---RFNTYNFLAHAKGKST---------GIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYE---SSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTK 1926
            F+ ++ ++R+   DF ++K +G+G FG V +V+ KS++ V+AMKI++K   +  +    F EERD++ +  S W+    Y F D   LY+VM+Y  GGDL   +++ ED   +E   FY  E+VLA+  +H + ++HRD+KPDN+LLD NGH++LADFG+C++   +G V+++  VGTPDYI PEIL+       + G E DWW+ G+ +YE+ +GETPF  ES    Y  IM +K    +P +      +  D +  ++    +R    GI   K+HP+   +G  W+  +IR  ++P I EVS   DT+    D +  +N  +    ++  FSG +L F GFTF      +    L  A+  S+         G+E +++ +   E ++   E  KQ+L+ KL  +   L   Q++ S      KD E  I   K E E   SS   +  ++  +   S   E  N   +Q+K +    E  LK  + E  ++  E+  +   L T  + L  AH    ++   +    +IN    E +S+ Q L  ++  K
Sbjct:    4 FTTRVKEMRLHREDFEMLKVIGRGAFGEVAVVKLKSSEKVFAMKILNKWEMLKRAETACFREERDVLVRGDSQWITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPEEMAKFYVAEMVLAIHSIHELKYVHRDIKPDNVLLDMNGHIRLADFGSCLKLLTDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLFGETPFYAESLVETYGKIMNHKERFQFPTNSVEVSDDGKDLIRHLICSREQRFGRNGIQDFKNHPFF--AGIDWD--NIRNCEAPYIPEVSSPTDTSNFDVDDDYLKNTEAVPPPSHTAFSGLHLPFVGFTFTTKCSLSDRGMLKSAEESSSNPPDGLVQRGLEDSLA-VEAYERRIKRMEQEKQELTRKLQESMQALSFGQRESSSPSPSSKDTE--IRKLKEEVERLRSSQPESWCVEPSVVTDSPRREPLNEASQQVKQL----EKQLKVTRQEKDDMHRELQEAHDRLKTQTKELKDAH---NQRKVAMAEFSEINERMTELRSQKQKLARQLRDK 543
[Close]
BLAST of Rho-associated kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005559.1 (pep scaffold:Pmarinus_7.0:GL476474:6865:57025:1 gene:ENSPMAG00000004999.1 transcript:ENSPMAT00000005559.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 240.736 bits (613), Expect = 1.734e-64
Identity = 134/356 (37.64%), Postives = 203/356 (57.02%), Query Frame = 1 
Query:  301 IKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVN-NSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQ-THFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPF-EGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDT-NYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNR 1353
            I  F+ + +    ++ +LRV+ SDF V   V +G    V +VR ++T +VYAMK++ KS  ++ ++   F EERD++A+ SS WL    Y F D   LY+VMEY PGGDL   +   ED  DE    FY  ELVLA + LH MG++HRDLKP+N+L+D+ GH+KLADFG+  +   N  V +    G+PDYI PE+L +        G E DWW+ G++ YE+ YG+TPF EG ST T+  NI  ++  + +P +     EF+D +  +L    +R+    +  HP+   +G  WN  +I+    P +  + G+DDT N+   +        +   +    FSG NL F GF++++
Sbjct:   72 IANFVSKHAETVSELQELRVTSSDFEVRGVVSRGHHSEVQVVRERATGDVYAMKVLQKSLLLHRDNVALFEEERDVLARASSPWLTHLQYAFQDEDNLYLVMEYHPGGDLLGLLGRYEDQLDESMVRFYLAELVLATQSLHQMGYVHRDLKPENVLVDRTGHIKLADFGSAAKLNANKMVSSKLPEGSPDYIAPEVLSSFSGKG-SYGPECDWWSVGVIAYEMVYGKTPFAEGISTKTI-SNIKNFQKFVRFPSEPAVSVEFVDLVKGLLCGRVDRLTPDKLLCHPFF--AGIDWN--NIQHMPPPFVPPLQGDDDTSNFEEVERERPAAPPTPRQLRQPGFSGNNLPFIGFSYSK 421
[Close]
BLAST of Rho-associated kinase vs. Ensembl Yeast
Match: DBF2 (Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication [Source:SGD;Acc:S000003324])

HSP 1 Score: 187.963 bits (476), Expect = 7.415e-51
Identity = 110/346 (31.79%), Postives = 162/346 (46.82%), Query Frame = 1 
Query:  349 KLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKST-FVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCI------RTKNGKVK----------------------------------TNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFI----DFMSKILTEPTERM-DITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYI 1248
            +L+    DF +I  VGQGG+G+V L R K TK V A+KI++K   F  N       ERDI+    S+WL+K  Y F DL+ LY+ ME++PGGD    +            FY  E+  AV  LH++G+ HRDLKP+N L+D  GH+KL DFG         R ++ K++                                   N  VG+PDY+  E+L        +  F  D+W+ G +++E   G TPF G ST+  Y N+ R+K TL  P     +  F     D +++++ +P  R+     +K   Y  +     NFS +R    P   ++  E D  Y 
Sbjct:  169 RLKPKNRDFEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQDLQSLYLAMEFVPGGDFRTLLINTRCLKSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAAGTISNERIESMKIRLEKIKDLEFPAFTEKSIEDRRKMYNQLREKEINYANSMVGSPDYMALEVLEGK-----KYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYDNLRRWKQTLRRPRQSDGRAAFSDRTWDLITRLIADPINRLRSFEHVKRMSYFAD----INFSTLRSMIPPFTPQLDSETDAGYF 505
[Close]
BLAST of Rho-associated kinase vs. Ensembl Yeast
Match: DBF20 (Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication [Source:SGD;Acc:S000006315])

HSP 1 Score: 179.489 bits (454), Expect = 5.043e-48
Identity = 105/347 (30.26%), Postives = 162/347 (46.69%), Query Frame = 1 
Query:  349 KLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKST-FVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCI------RTKNGKVK----------------------------------TNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFI----DFMSKILTEPTERMDITGIKSHPYLTNSGY--KWNFSDIREHQSPVIFEVSGEDDTNYI 1248
            +L+    DF ++  VGQGG+G+V L + K +  + A+KI++K   F  N  N    ERDI+    SDWL+K  Y F D + LY+ ME++PGGD    +            FY  E+  AV  LH +G+ HRDLKP+N L+D  GH+KL DFG         R ++ K++                                   N  VG+PDY+  E+L        +  F  D+W+ G +++E   G TPF G ST+  Y+N+  +K TL  P  +  +  F     D +++++ +P  R     ++S   +    Y  + NF  +R    P I ++  E D  Y 
Sbjct:  161 RLKPKHKDFQILTQVGQGGYGQVYLAKKKDSDEICALKILNKKLLFKLNETNHVLTERDILTTTRSDWLVKLLYAFQDPESLYLAMEFVPGGDFRTLLINTRILKSGHARFYISEMFCAVNALHELGYTHRDLKPENFLIDATGHIKLTDFGLAAGTVSNERIESMKIRLEEVKNLEFPAFTERSIEDRRKIYHNMRKTEINYANSMVGSPDYMALEVLEGK-----KYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYENLRYWKKTLRRPRTEDRRAAFSDRTWDLITRLIADPINR-----VRSFEQVRKMSYFAEINFETLRTSSPPFIPQLDDETDAGYF 497
[Close]
BLAST of Rho-associated kinase vs. Ensembl Yeast
Match: YPK2 (Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000004710])

HSP 1 Score: 180.259 bits (456), Expect = 1.546e-47
Identity = 93/277 (33.57%), Postives = 158/277 (57.04%), Query Frame = 1 
Query:  358 VSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNS-FNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPD--DKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYK 1170
            +S+ DF ++K +G+G FG+V  VR K T+ +YA+K + K+  V+         ER ++A+    +++   ++F   +KLY+V+ ++ GG+L++ +     FS  ++ FY  EL+ A++ LH +  I+RDLKP+N+LLD  GH+ L DFG C        KT+   GTP+Y+ PEIL   G          DWW  GI++YE+  G  P+  E+   +Y+ I+  +  L++PD  D  AK   I  +S+   +P+ R+ + G   I++HP+  +  +K
Sbjct:  339 LSIDDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTK-----TVDWWTLGILLYEMMTGLPPYYDENVPVMYKKIL--QQPLLFPDGFDPAAKDLLIGLLSR---DPSRRLGVNGTDEIRNHPFFKDISWK 605
[Close]
BLAST of Rho-associated kinase vs. Ensembl Yeast
Match: FPK1 (Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments and thplasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; FPK1 has a paralog, KIN82, that arose from the whole genome duplication [Source:SGD;Acc:S000005330])

HSP 1 Score: 181.415 bits (459), Expect = 3.838e-47
Identity = 107/335 (31.94%), Postives = 178/335 (53.13%), Query Frame = 1 
Query:  295 KPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFV-NNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMT--ELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKV---------------------KTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTE-----RMDITGIKSHPYLTNSGYKWNFSDIREHQSPVI 1212
            +P ++   R  +FS K   + V    F  I+ +GQG  G+V LVR K T  VYA+K++ K   +  N       E++I+A ++  +++  +++F     LY+ MEY  GG+ +  +   + +   ++   FYA E+  A+E LH +GFI+RDLKP+N+LL ++GH+ L+DF   I+ K+ KV                     +TN  VGT +YI PE++R  G H   V    DWW  GI+IYE+ +G TPF+G++T+  + NI+  K+ + +P++        D + K+LT+        +M    +K HP+      K  +S +R  + P+I
Sbjct:  470 EPRRSRRLRTKSFSNKFQDIMVGPQSFEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCMGGEFFRALQTRKTKCICEDDARFYASEVTAALEYLHLLGFIYRDLKPENILLHQSGHIMLSDFDLSIQAKDSKVPVVKGSAQSTLVDTKICSDGFRTNSFVGTEEYIAPEVIRGNG-HTAAV----DWWTLGILIYEMLFGFTPFKGDNTNETFTNIL--KNEVSFPNNNEISRTCKDLIKKLLTKNESKRLGCKMGAADVKKHPFFK----KVQWSLLRNQEPPLI 793
[Close]
BLAST of Rho-associated kinase vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124])

HSP 1 Score: 171.4 bits (433), Expect = 6.674e-47
Identity = 103/308 (33.44%), Postives = 166/308 (53.90%), Query Frame = 1 
Query:  343 IYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVN-NSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERM------DITGIKSHPYLTNSGYKWNFS-DIREHQSPVIFEVSGEDDTN 1242
            + K + +L DF +++T+G G FGRV LVR       YA+K++ K   V         +ER ++      +LI+ + TF D + +++VM+Y+ GG+L+  + + + F +    FYA E++LA+E LH    I+RDLKP+N+LLD+NGH+K+ DFG     K  +  T    GTPDYI PE++     +        DWW+ G++IYE+  G TPF   +    Y+ I++ K  ++YP      P+ +D +SK++T    R           IK+HP+ +   ++   + DI     P I   SG  DT+
Sbjct:   60 VSKGKYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFA---KEVQTVTWTLCGTPDYIAPEVITTKPYNK-----SVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGK--VVYPPY--FHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPI--TSGIGDTS 353
[Close]
BLAST of Rho-associated kinase vs. Ensembl Nematostella
Match: EDO37677 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF23])

HSP 1 Score: 241.891 bits (616), Expect = 1.738e-70
Identity = 131/361 (36.29%), Postives = 209/361 (57.89%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKS-TFVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDT-NYITYDPXXXXXXXXXXXXXXXXX---XGENLAFSGFTF 1347
            K  K I  F+ ++     ++ +L +S +DF V+ T+G+G FG V +V+ K+T +VYAMK + KS T    +   F EER+IMA  ++ W+    Y F D   LY+VM+Y PGGDL   +++ +D F ++   FY  E+V+A+  LH MGF+HRD+KPDN+L+D+ GH+KLADFG+  R + + KV +   VGTP+YI PE+L +        G E DWW+ G+V YE+ +G+TPFE +S    Y  IM +KS+L +P +     +  + +  +LT    R+   G+  H +   +G +WN   ++    P +  + G DDT N+  ++P+    +    +   +      G++L F GF+F
Sbjct:   53 KKDKNIATFVKKYQPMINELRRLSLSKNDFNVVNTIGRGHFGEVQVVKDKATGDVYAMKTLKKSQTLSEEAVAFFEEEREIMATANNPWITSLQYAFQDSHSLYLVMDYHPGGDLLSLLSKYDDIFEEDMARFYLAEIVMAIHSLHTMGFVHRDVKPDNVLIDRTGHIKLADFGSSARLSADKKVFSKMPVGTPEYIAPEVLTSMDGSGGAYGVECDWWSLGVVAYEMLFGQTPFEADSVVVTYSKIMNFKSSLRFPSEPKISEDAKELIHNLLTSSEGRIGYEGLGCHKFF--NGIEWN--KLQNTLPPYVPTLDGTDDTSNFDEFEPDSDEMDQLKKYSFCSEEKGFKGKDLPFVGFSF 409
[Close]
BLAST of Rho-associated kinase vs. Ensembl Nematostella
Match: EDO32008 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SW88])

HSP 1 Score: 234.958 bits (598), Expect = 9.102e-70
Identity = 113/243 (46.50%), Postives = 162/243 (66.67%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLY 1008
            + +K ++ FL R+   +  I   R++  DF  +K +G+G FG V LVRH  TK VYAMK++ K   +  S + F WEER+IMA ++S+W++K  Y F D K LY+VM+YM GGDL + M+  E   ++   FY  E+VLA++ +H MGF+HRD+KPDNMLLD  GH+KLADFGTC+R  ++G V+++  VGTPDYI PE+L++ G      G E DWW+ G+ +YE+  G+TPF  +S    Y
Sbjct:   38 RRNKNVENFLQRYEQPTRVIQTHRLNNDDFKTLKVIGRGAFGEVQLVRHTHTKKVYAMKLLSKFEMIKRSDSAFFWEEREIMAHSNSNWIVKLHYAFQDEKYLYMVMDYMSGGDLVNLMSNYE-IPEKWAKFYCAEVVLALDAIHTMGFVHRDVKPDNMLLDGEGHLKLADFGTCMRMDRDGMVRSDTAVGTPDYISPEVLKSQGGEGY-YGRECDWWSVGVFLYEMLVGDTPFYADSLVGTY 278
[Close]
BLAST of Rho-associated kinase vs. Ensembl Nematostella
Match: EDO42700 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0M7])

HSP 1 Score: 209.149 bits (531), Expect = 1.339e-58
Identity = 111/341 (32.55%), Postives = 183/341 (53.67%), Query Frame = 1 
Query:  340 KIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNN-SFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKVKTNF-------------------------------------QVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERM-DITGIKSHPYLTNSGYKW-NFSDIREHQSPVIFEVSGEDDTN 1242
            ++ + R+   DF  +K +G+G FG V LV+ + T +VYAMKI+ K+  +          ERDI+A+  + W++K +Y+F D   L++VME++PGGDL   + + + F++E+T FY  E +LA++ +H +GFIHRD+KPDN+LLD  GH+KLADFG C   K    +T F                                      VGTPDYI PE+    G          D+W+ G+++YE+  G  PF  ES    Y+ +M ++ TL++P + P  P   D +S+      +R+ +I  I++ P+     +K+ ++ ++R+  + +  +V   DDT+
Sbjct:   83 RLKRSRIGKEDFDSLKVIGRGAFGEVRLVQKQDTGHVYAMKILRKADMLEKEQVAHARAERDILAEAENQWVVKMYYSFQDDYYLFLVMEFLPGGDLMTLLMKKDTFTEEETRFYIAEALLAIDSIHQLGFIHRDIKPDNLLLDSRGHIKLADFGLCTGLKKAH-RTEFYRDISPADIKDFSNGDPLDSKRRAATWKRNRRQLAYSTVGTPDYIAPEVFIQQGYTK-----SCDFWSLGVIMYEMLIGYPPFCSESPQETYKKVMNWRETLVFPPEMPISPNARDLISR------QRLSNIEDIRAQPF-----FKYVDWENLRDRPAALPIQVKSIDDTS 406
[Close]
BLAST of Rho-associated kinase vs. Ensembl Nematostella
Match: EDO35585 (Protein kinase C [Source:UniProtKB/TrEMBL;Acc:A7SL27])

HSP 1 Score: 181.415 bits (459), Expect = 2.316e-47
Identity = 96/234 (41.03%), Postives = 143/234 (61.11%), Query Frame = 1 
Query:  355 RVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDK-STFVNNSFNGFWEERDIMAKNSS-DWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYP 1047
            +++L DF  IK +G+G FG+V L   K T  VYA+KI+ K S   ++       ER ++A ++   +L     +F  +++L+ VMEY+ GGDL   + +   F + ++ FYA E+VLA++ LH  G I+RDLK DN+LLD +GH+KLADFG C      GK  T F  GTPDYI PEIL+     +   GF  DWWA G+++YE+  G+ PFE E+   L+++I+     ++YP
Sbjct:  377 KMTLKDFTFIKVLGKGSFGKVLLAERKGTDEVYAIKILKKESVLQDDDVECTMIERRVLALSAGHPFLTSLHSSFQTVERLFFVMEYVNGGDLMFQIQKSRKFDENRSRFYAAEVVLALQFLHQNGVIYRDLKLDNVLLDADGHIKLADFGMCKENMAPGKTTTTF-CGTPDYIAPEILQ-----EQPYGFSVDWWALGVLMYEMMAGQPPFEAENEEDLFESILH--DDVLYP 602
[Close]
BLAST of Rho-associated kinase vs. Ensembl Nematostella
Match: EDO36034 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJR1])

HSP 1 Score: 165.236 bits (417), Expect = 6.737e-44
Identity = 105/370 (28.38%), Postives = 171/370 (46.22%), Query Frame = 1 
Query:  340 KIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKS-TFVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKP--------------------------DNMLLDKNGHMKLADF-----------GTCIR--------------------TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFE--TDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDP 1260
            ++ + ++ +S F  I+T+G G FG V LVR   T  +YAMKI+ KS  F  N       ERDI+A+  ++W++K +Y+F D + LY VM+Y+PGGDL   + +   F ++   FY  ELVLA++ +H MGF+HRD+KP                          D+   +K  HM+                TC                       K+ + + +  VGTP+YI PE+L       L +G+    DWW+ G+++YE+  G+ PF   + +     I+ +++ L  P       E  D + ++ T    R+   G   IK+HP+     + +    ++   +PVI   +  D  N+   DP
Sbjct:   27 RLKRTKMDISMFEKIRTIGIGAFGEVWLVRKTDTSMLYAMKILRKSEVFRRNQAAHVKAERDILAEADNEWVVKLYYSFQDQENLYFVMDYVPGGDLMSLLIKFGIFPEDYAKFYIAELVLAIDSVHRMGFVHRDIKPDNILIDKDGHIKLTDFGLCTGFRWTHDSKYYEKGQHMRQDSMEPDERAWEEMRATCHCGDISIDKPYSEMKPLERRHFRKHMRCQAHSLVGTPNYIAPEVL-------LRIGYRQSCDWWSVGVILYEMLVGQPPFLAPTPAETQLKIINWETELRIPHQARLSREAKDLILRLCTNADMRLGSNGASEIKAHPFFACVDWAYLAKRVQAPYTPVIRFPT--DTANFDPVDP 387
[Close]
BLAST of Rho-associated kinase vs. Ensembl Medaka
Match: rock1 (Rho associated coiled-coil containing protein kinase 1 [Source:NCBI gene;Acc:101158388])

HSP 1 Score: 317.39 bits (812), Expect = 5.286e-89
Identity = 189/533 (35.46%), Postives = 295/533 (55.35%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFL-----AHAKGK-STGIEGNISNLTELETKLSEAE-------LAKQQLSLKLDNTTNELGKTQKKLS---------DAVRELKDREQLINTNK-SEYESSIDNNKLLKAKIEN--------------ISKLIESSNREIEQLKSVIGEKENLLKS 1725
            + YD+      KN K I  FL+R+     KI  LR+   D+ V+K +G+G FG V LVRHK+T+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ F+ F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK GH+KLADFGTC++  K+G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ ++E+  G+TPF  +S    Y  IM +K+ L +PDD     +  + +   LT+   R+   G   IK HP+  N   +W + +IR+  +PV+ E+S + DT+   +D  +        F     F G  L F GFT+  ++  + L     A A+ K S+  + + S+L  L+ ++ + E         K +L  K   +   + K  K+L          +A   L ++++++  ++ +EY+   D     +  +EN              IS+  ++SN  I QL+  + E  N+L++
Sbjct:   37 LVYDLDFPALRKN-KSIDNFLNRYKETISKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSSWVVQLFFAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKAGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMNHKNALTFPDDSDISNDAKNLICAFLTDREVRLGRNGVDEIKRHPFFKND--QWTWENIRDTAAPVVPELSSDTDTS--NFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTY--YSNQDLLRCSTSAKAREKHSSSAKEDKSHLESLQKRIHQLEEQLHGEMQLKDELEQKCRASNTRIEKIVKELDEEANLRKTVEASMSLLEKDKMMLQHRFTEYQRKADQEAEKRRNLENEVSTLKEQLEDMKKISQNSQASNDRIVQLQKQLEEANNMLRA 560

HSP 2 Score: 63.929 bits (154), Expect = 1.254e-9
Identity = 77/343 (22.45%), Postives = 135/343 (39.36%), Query Frame = 1 
Query: 2737 EMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQT-WQDQC---KELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIK-----DNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGP----INVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWC------PDAIEIFLFKVESKEAKNAWISCLN 3699
            +M  + K    ++  +KKEK +       R+L+ +L++EK KF     +     +E Q    D+C    EL+ +L  K + I+ L + LN DM  +   S   S++      N  +S       +       +  W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    +   +P+I QI+Y                              ++G     S   V+  P G     +  + H F+P  +   ++C+ C +   +   PPPALEC  C  + H++HL   E  I  C        A ++ L  +  +E K  WI  L 
Sbjct: 1021 DMKADQKKKGSMADLRKKEKEN-------RKLQLELNQEKDKFNHMAIKYQKELSEMQAQLSDECLHRNELQMQLASKESDIEQLREKLN-DMQQRIENSSITSLQTDETDSNIAESRLEGWLSIPNRANIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPRIFQILY-----------------------------ANEGECRKESE--VETAPQGDKTNCLPHKGHEFIPTLYHFPSSCEACSKPLWNVFKPPPALECRRCHVKCHKDHLDKKEDVIAPCKVNYDVTSARDMLLLALTQEEQKK-WIGHLG 1323
[Close]
BLAST of Rho-associated kinase vs. Ensembl Medaka
Match: rock2b (rho-associated protein kinase 2 [Source:NCBI gene;Acc:101159717])

HSP 1 Score: 314.309 bits (804), Expect = 2.685e-88
Identity = 176/469 (37.53%), Postives = 268/469 (57.14%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNT-TNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIEN 1641
            +++D++     KN K I+AFL+R+     ++ +L+V L DF  +K +G+G FG V LVRHK+++ VYAMK + K   +  S + F WEER+IMA ++S W+++    F D + LY+VME+MPGGDL   +T   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLD  GH+KLADFGTC++   +G V  +  VGTPDYI PE+L++ G  +   G E DWW+ G+ IYE+F GETPF  ES    Y  IM +++TL++PDD     E  D +   L++   R+  TG   IK HP+  N   +W F +IR+  +PV+ E++ + DT    +D  +     +  F     F G  L F GFT+ + N   FL         +E     L +LE +L     AK +L  K     T     +++++  ++R+L+    L+    +E    ++     K  +EN
Sbjct:    4 LAHDLNYPVLRKN-KNIEAFLNRYEKVVSQLQELQVKLDDFEKVKLIGRGAFGEVQLVRHKTSQKVYAMKKLSKFEMIKRSDSAFFWEERNIMAFSNSPWIVQLCCAFQDRRHLYMVMEFMPGGDLV-TLTMNYDLPEKWACFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDHLGHLKLADFGTCMKMDSSGMVHCDTAVGTPDYISPEVLQSQG-GEGHYGRECDWWSVGVFIYEMFVGETPFYAESLVGTYGKIMNHQNTLVFPDDVEMSQEAKDLICAFLSDREVRLGRTGVDEIKRHPFFKNE--QWTFDNIRDTVAPVVPELNSDIDTT--NFDDIEEDKGHAETFPPPKAFVGNQLPFIGFTYFKENQLEFLCSGFSVCYVLEQLKKKLDQLEEQLDHEMQAKDELEQKCKYEWTRRHMNSRQRVEASLRQLERERALLQHQSAESLRKVELEAGRKRSLEN 465

HSP 2 Score: 66.2402 bits (160), Expect = 2.212e-10
Identity = 41/178 (23.03%), Postives = 77/178 (43.26%), Query Frame = 1 
Query: 3109 ISWLPYFAVLKP---FKLE----------LYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHL 3594
            ++W+ Y   ++P   F+L+           Y  E D   ++ + S+D+  + H+R  +  +    D   +P+I QI+Y   D   + +R+   +V++       T  +D                N  I+ + H FV   +   T C+ C++       PPPA+EC  C  + H++HL
Sbjct: 1095 LTWVTYATTVQPPHPFRLQYVVVSSKNILFYNSEQDKDQHLAYMSLDISKLFHVRSVTQTDVYRADPKEIPKIFQILY---DNEGESKREQEATVET-------TSNID---------------RNNLISHKGHEFVVTLYHFPTNCETCNKPLWHVFKPPPAIECRRCHFKFHKDHL 1247
[Close]
BLAST of Rho-associated kinase vs. Ensembl Medaka
Match: rock1 (Rho associated coiled-coil containing protein kinase 1 [Source:NCBI gene;Acc:101158388])

HSP 1 Score: 312.768 bits (800), Expect = 1.710e-87
Identity = 148/335 (44.18%), Postives = 214/335 (63.88%), Query Frame = 1 
Query:  253 ISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIR-TKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTN 1242
            + YD+      KN K I  FL+R+     KI  LR+   D+ V+K +G+G FG V LVRHK+T+ VYAMK++ K   +  S + F WEERDIMA  +S W+++ F+ F D + LY+VMEYMPGGDL + M+   D  ++   FY  E+VLA++ +H+MGFIHRD+KPDNMLLDK GH+KLADFGTC++  K+G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ ++E+  G+TPF  +S    Y  IM +K+ L +PDD     +  + +   LT+   R+   G   IK HP+  N   +W + +IR+  +PV+ E+S + DT+
Sbjct:   37 LVYDLDFPALRKN-KSIDNFLNRYKETISKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSSWVVQLFFAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKAGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQG-GDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMNHKNALTFPDDSDISNDAKNLICAFLTDREVRLGRNGVDEIKRHPFFKND--QWTWENIRDTAAPVVPELSSDTDTS 366

HSP 2 Score: 63.5438 bits (153), Expect = 1.381e-9
Identity = 77/343 (22.45%), Postives = 135/343 (39.36%), Query Frame = 1 
Query: 2737 EMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQT-WQDQC---KELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIK-----DNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGP----INVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWC------PDAIEIFLFKVESKEAKNAWISCLN 3699
            +M  + K    ++  +KKEK +       R+L+ +L++EK KF     +     +E Q    D+C    EL+ +L  K + I+ L + LN DM  +   S   S++      N  +S       +       +  W   + V+   K+  Y  E D   + P   +D+  + H+R  +  +    +   +P+I QI+Y                              ++G     S   V+  P G     +  + H F+P  +   ++C+ C +   +   PPPALEC  C  + H++HL   E  I  C        A ++ L  +  +E K  WI  L 
Sbjct:  993 DMKADQKKKGSMADLRKKEKEN-------RKLQLELNQEKDKFNHMAIKYQKELSEMQAQLSDECLHRNELQMQLASKESDIEQLREKLN-DMQQRIENSSITSLQTDETDSNIAESRLEGWLSIPNRANIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPRIFQILY-----------------------------ANEGECRKESE--VETAPQGDKTNCLPHKGHEFIPTLYHFPSSCEACSKPLWNVFKPPPALECRRCHVKCHKDHLDKKEDVIAPCKVNYDVTSARDMLLLALTQEEQKK-WIGHLG 1295
[Close]
BLAST of Rho-associated kinase vs. Ensembl Medaka
Match: rock2a (rho-associated protein kinase 2 [Source:NCBI gene;Acc:101172697])

HSP 1 Score: 287.345 bits (734), Expect = 4.883e-79
Identity = 228/783 (29.12%), Postives = 383/783 (48.91%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHA----------KGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAV----------RELKD---------------------------------REQLINTNKSEYESSIDN-------------NKLLKAKIENISKLIES---SNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTR------------------------KINEFELQLELISSRAKDNVLLD-SNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLN-NEKIQK-SELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQ 2331
            + +K I+ FL+R+    E++  L++   DF  +K +G+G FG V LVRHK+++ VYAMK++ K   +  S + F WEER IMA  +S W+++    F D   LY+VMEYMPGGDL + +T   D  ++   FY  E+V+A++ +H+MGFIHRD+KPDNMLLD+ GH+KLADFGTC++    G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ I+E+  G+TPF  +S    Y  IM +K++L +P++     +  + +   LT+   R+   G   IK HP+  N   +W F +IRE  +PV+ E+S   D +   +D  +              F G  L F G  F  F     L  +          KG+S  ++     L  LE + +  +  K  L  K    +  L K  K+L + V          R+L+                                  R+QL +  +    S I N             N LL+A+ E  ++L ++   S+++++QL++ + E ++    L+    +L  E  S + +L T ++  S+  E I       D M +I +L +E + + Q L ++  T+ R                        K+ + EL+ E  S +A   +L D S ++     ++   + + E++  E RL  M  +   +E EK++   D +  + +QK  EL   +D L+++V N  LK+     + N  ++  +  NQ+++++ + + Q++Q+
Sbjct:   26 RKNKNIETFLNRYEKVVEELRDLQMKSEDFEKVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERGIMAFANSPWVVQLCCAFQDEHYLYMVMEYMPGGDLVN-LTSTYDVPEKWAKFYTAEVVMALDAIHSMGFIHRDVKPDNMLLDRLGHLKLADFGTCMKMDATGMVRCDTAVGTPDYISPEVLKSQG-GDGCYGRECDWWSVGVFIFEMLVGDTPFYADSLVGTYSKIMDHKNSLHFPEEVEISADAKNIICAFLTDREVRLGRNGVEEIKQHPFFKND--QWTFDNIRETVAPVVPELSS--DIDTSNFDEIEDDKGDVETVPTPKAFVGNQLPFVG--FTYFKEDQLLNASNNSSVNNENLKGESAALQ---KKLHHLELQFNNDKQVKDDLEQKYRTASGRLEKITKELEEEVNCRKCLESNLRQLEREKALLQHKSLESHRKAESEADRKRCLENEVNSLRDQLDDLKRRNQNSHISNEKNIHLRRQLEEANTLLRAESEAATRLRKTQTESSKQLQQLEANVRELQDKCCLLERTKLSLEKECISLQAALETERREQSQGSETIS------DLMGRILALEQEARQQRQAL-SKAETEKRHLQDKLTDLEKEMSSKEIDLTYQLKVLQQELEQEETSHKATRALLADKSKIRVTIEGAKSESMKEMEQKLSEERLAKMRLENRILELEKHSSMMDCDYKQALQKLEELRRHKDHLTEEVKNLTLKIEQETQKRNLTQNDLKAQNQQLSILRTSEKQLKQE 790

HSP 2 Score: 73.559 bits (179), Expect = 1.571e-12
Identity = 92/409 (22.49%), Postives = 162/409 (39.61%), Query Frame = 1 
Query: 2680 QKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKI---RQLETDLSKEK-------VKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNII---KDLMKSLNNDMIPKESPSD--ELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGP----INVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL-----------NSLKEYQKKAEIQIAPNTYYRSVRVPGRHSPA 3792
            +K+LQS++      V K+ E+M N K +    SR+     D D  RK    R+L+ +L  EK       +K+Q   +E N+ + +         EL+  L+ K++ I   ++L+++L+   +   S S   E    D   ++       L       K  W   + V+   K+  Y  E D   ++P+  +D+  + H+R  +  +    D   +P+I QI+Y                              ++G S       V+  P G     I  + H F+P  +   T C+ C +   +   PPPALEC  C  + H++H+   E  I  C    ++      L    S+E +  W+S L                   +A +++ P+   +S+R P R  P 
Sbjct:  981 EKQLQSERTLKTQAVNKLAEIM-NRKEIRGGGSRRN---NDTDMRRKEKENRKLQLELRSEKEKLNSIMIKYQ---REINEMQAQLADESQMRIELQMALDSKDSDIEQLRNLLQTLSVQSMDSASVSSGPEFDADDAYTETRLEGWLSLPVRNNTKKFGWERKYVVVSSKKILFYNSEQDREQSIPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILY-----------------------------ANEGESKKEPEFPVEPLPLGEKSSYICHKGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVNYDVSAAKNLLLLAASQEEQQKWVSRLVKKIPKKPPPTELFARSSPRASMKVQPS---QSMRRPSRQLPT 1350
[Close]
BLAST of Rho-associated kinase vs. Ensembl Medaka
Match: rock2a (rho-associated protein kinase 2 [Source:NCBI gene;Acc:101172697])

HSP 1 Score: 287.345 bits (734), Expect = 5.210e-79
Identity = 228/783 (29.12%), Postives = 383/783 (48.91%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGF-WEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRT-KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITG---IKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHA----------KGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAV----------RELKD---------------------------------REQLINTNKSEYESSIDN-------------NKLLKAKIENISKLIES---SNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTR------------------------KINEFELQLELISSRAKDNVLLD-SNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLN-NEKIQK-SELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQ 2331
            + +K I+ FL+R+    E++  L++   DF  +K +G+G FG V LVRHK+++ VYAMK++ K   +  S + F WEER IMA  +S W+++    F D   LY+VMEYMPGGDL + +T   D  ++   FY  E+V+A++ +H+MGFIHRD+KPDNMLLD+ GH+KLADFGTC++    G V+ +  VGTPDYI PE+L++ G  D   G E DWW+ G+ I+E+  G+TPF  +S    Y  IM +K++L +P++     +  + +   LT+   R+   G   IK HP+  N   +W F +IRE  +PV+ E+S   D +   +D  +              F G  L F G  F  F     L  +          KG+S  ++     L  LE + +  +  K  L  K    +  L K  K+L + V          R+L+                                  R+QL +  +    S I N             N LL+A+ E  ++L ++   S+++++QL++ + E ++    L+    +L  E  S + +L T ++  S+  E I       D M +I +L +E + + Q L ++  T+ R                        K+ + EL+ E  S +A   +L D S ++     ++   + + E++  E RL  M  +   +E EK++   D +  + +QK  EL   +D L+++V N  LK+     + N  ++  +  NQ+++++ + + Q++Q+
Sbjct:   55 RKNKNIETFLNRYEKVVEELRDLQMKSEDFEKVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERGIMAFANSPWVVQLCCAFQDEHYLYMVMEYMPGGDLVN-LTSTYDVPEKWAKFYTAEVVMALDAIHSMGFIHRDVKPDNMLLDRLGHLKLADFGTCMKMDATGMVRCDTAVGTPDYISPEVLKSQG-GDGCYGRECDWWSVGVFIFEMLVGDTPFYADSLVGTYSKIMDHKNSLHFPEEVEISADAKNIICAFLTDREVRLGRNGVEEIKQHPFFKND--QWTFDNIRETVAPVVPELSS--DIDTSNFDEIEDDKGDVETVPTPKAFVGNQLPFVG--FTYFKEDQLLNASNNSSVNNENLKGESAALQ---KKLHHLELQFNNDKQVKDDLEQKYRTASGRLEKITKELEEEVNCRKCLESNLRQLEREKALLQHKSLESHRKAESEADRKRCLENEVNSLRDQLDDLKRRNQNSHISNEKNIHLRRQLEEANTLLRAESEAATRLRKTQTESSKQLQQLEANVRELQDKCCLLERTKLSLEKECISLQAALETERREQSQGSETIS------DLMGRILALEQEARQQRQAL-SKAETEKRHLQDKLTDLEKEMSSKEIDLTYQLKVLQQELEQEETSHKATRALLADKSKIRVTIEGAKSESMKEMEQKLSEERLAKMRLENRILELEKHSSMMDCDYKQALQKLEELRRHKDHLTEEVKNLTLKIEQETQKRNLTQNDLKAQNQQLSILRTSEKQLKQE 819

HSP 2 Score: 73.559 bits (179), Expect = 1.515e-12
Identity = 92/408 (22.55%), Postives = 162/408 (39.71%), Query Frame = 1 
Query: 2680 QKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKI---RQLETDLSKEK-------VKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNII---KDLMKSLNNDMIPKESPSD--ELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGEND---NVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGP----INVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEI-----FLFKVESKEAKNAWISCL-----------NSLKEYQKKAEIQIAPNTYYRSVRVPGRHSP 3789
            +K+LQS++      V K+ E+M N K +    SR+     D D  RK    R+L+ +L  EK       +K+Q   +E N+ + +         EL+  L+ K++ I   ++L+++L+   +   S S   E    D   ++       L       K  W   + V+   K+  Y  E D   ++P+  +D+  + H+R  +  +    D   +P+I QI+Y                              ++G S       V+  P G     I  + H F+P  +   T C+ C +   +   PPPALEC  C  + H++H+   E  I  C    ++      L    S+E +  W+S L                   +A +++ P+   +S+R P R  P
Sbjct: 1010 EKQLQSERTLKTQAVNKLAEIM-NRKEIRGGGSRRN---NDTDMRRKEKENRKLQLELRSEKEKLNSIMIKYQ---REINEMQAQLADESQMRIELQMALDSKDSDIEQLRNLLQTLSVQSMDSASVSSGPEFDADDAYTETRLEGWLSLPVRNNTKKFGWERKYVVVSSKKILFYNSEQDREQSIPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILY-----------------------------ANEGESKKEPEFPVEPLPLGEKSSYICHKGHEFIPTLYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVNYDVSAAKNLLLLAASQEEQQKWVSRLVKKIPKKPPPTELFARSSPRASMKVQPS---QSMRRPSRQLP 1378
[Close]
BLAST of Rho-associated kinase vs. Planmine SMEST
Match: SMESG000057753.1 (SMESG000057753.1)

HSP 1 Score: 2255.33 bits (5843), Expect = 0.000e+0
Identity = 1216/1216 (100.00%), Postives = 1216/1216 (100.00%), Query Frame = 1 
Query:  148 MNSEDIVNKLSLIENEIFNPXXXXXXXXXXXXXXXISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEXXXXXXXXXXXXQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSXXXXXXXXXXXXXXSRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAXXXXXXXXXXXXXXXXXXXXXXXXTNSMNISMENDRLKAELVEVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIKDNXXXXXXXXXXXXXXXXXXXXISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPNTYYRSVRVPGRHSPAI 3795
            MNSEDIVNKLSLIENEIFNPSSDLYLDNLLDLASSISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPNDRRNNISNNFINNNYFSGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEISSSKISLSTLKQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSEDLELLQKEKQALESRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAQLEEQEECFLEKEKKFENDKKFLETNSMNISMENDRLKAELVEVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIKDNEMKSLEGKLEMLKKGKGKHKISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPNTYYRSVRVPGRHSPAI
Sbjct:    1 MNSEDIVNKLSLIENEIFNPSSDLYLDNLLDLASSISYDIHCSGTWKNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTKNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERMDITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPNDRRNNISNNFINNNYFSGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNTTNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEISSSKISLSTLKQNLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEFELQLELISSRAKDNVLLDSNLQSAPVKSEDLELLQKEKQALESRLISMMNDLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNRLNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAQLEEQEECFLEKEKKFENDKKFLETNSMNISMENDRLKAELVEVNKKLEDLKLIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQSDKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLSKEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNNDMIPKESPSDELSIKDNEMKSLEGKLEMLKKGKGKHKISWLPYFAVLKPFKLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQKPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPINVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLLSGEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPNTYYRSVRVPGRHSPAI 1216
[Close]
BLAST of Rho-associated kinase vs. Planmine SMEST
Match: SMESG000041847.1 (SMESG000041847.1)

HSP 1 Score: 307.76 bits (787), Expect = 3.557e-86
Identity = 161/402 (40.05%), Postives = 241/402 (59.95%), Query Frame = 1 
Query:  322 FSNFS-------EKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNNSFNGFW-EERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTK--NGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERM----DITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITY---DPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQL 1476
            F+NF        EK+   R+  SDF ++K +GQG FG+V LVRHK T +++A+KI++KS  V      FW EERDIM K  S W++K  Y F D K+LY+VM+Y+PGG+L +WM+++E   ++   FYA E+VLA+  LHN GF+HRD+KPDN+L+D  GH+KLADFG+C++       V  N  +GTPDYI PE+L +    + + G E DWWA G+++YE+FYGE PF  ++    Y  IM ++ +L +P D       +DFM K++ + + R+    D + IKSH +  NS  +W +  I++  SP I  +  + DT+Y  +   D +    N SN  + +  F GEN+ FSGF++ R+   N     K     +  NI N  +L++   E E++K  L
Sbjct:   53 FTNFYKQHKKVYEKLVDFRMKYSDFNLLKIIGQGAFGQVQLVRHKQTGDLFALKILNKSQVVTCEGTLFWQEERDIMMKIDSRWIVKLHYAFQDPKRLYMVMDYLPGGNLVNWMSKVEVLLEKDVCFYAAEIVLAINGLHNFGFVHRDIKPDNILIDIKGHIKLADFGSCVKMDPVTKYVNCNRAIGTPDYISPEVLLSQS-DNTKYGKEVDWWALGVMLYEIFYGEPPFYSDNLINTYGKIMTHEQSLSFPPDDEVSGMALDFMKKLICDRSVRLGQTKDASDIKSHIFFNNSSREWTWDTIQDSTSPFIPVLENDLDTSYFDFGEDDVDTNFLNQSNQGLKSTTFIGENIQFSGFSYIRWQNTN--KENKKSDNVLNSNIINEDKLQSTNKENEISKDIL 451
[Close]
BLAST of Rho-associated kinase vs. Planmine SMEST
Match: SMESG000049701.1 (SMESG000049701.1)

HSP 1 Score: 236.884 bits (603), Expect = 6.439e-63
Identity = 171/525 (32.57%), Postives = 276/525 (52.57%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNN-SFNGFWEERDIM---AKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTK-NGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYP---DDKPAKPEFIDFMSKILTEPTERMDITGI---KSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAK------------GKSTGIEGNI--SNLTELETKLSEAELAKQQLSLKLDNT-TNELGKTQKKLSDAVRE--LKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESS---NREIEQLKS----VIGEKENLLKSLK--TENCN 1746
            K+ K +  F+       +KI  LR+  SDF  I+ +G+G FG+V +VR K    +YAMK + K   +       F EERD++    K  S W+ +  Y F D   LY VM++  GGD+   +++  D   +E T FY  E+V++++V+H +G++HRD+KPDN+LLD  GH+ LADFG+C++ + NG   T   VGTPDYI PEILR+   H    G E DWW+ GIVI+E+ YGE PF  E  S  Y  IM +++    P   DD   + E  D + +++ +   R+   GI   K+HP+      + ++ ++R + +P I EVS  +DT+   +D     N        ++ F G +L   GFTF +   +N +   +            G    + GN   SN   L  ++++ ++   QL  +L+   TN +   Q+  S  V +  + D+E+L+ T    Y+ S      L+ K + I  LIE++   N++ ++L S    ++ +K+++ + LK  TEN N
Sbjct:   52 KDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHG-PYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAE--DLIKQLICKKECRLGNKGIDDFKNHPFFR----EIDWDNLRSYNAPFIPEVSSAEDTSNFEFD---DFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSV---QRIFSHPVYQQLVTDKEKLL-TQCQNYDYS------LREKEQKIDDLIETNRLLNKDRDELTSDRLQILQKKQDIEEDLKVMTENFN 556
[Close]
BLAST of Rho-associated kinase vs. Planmine SMEST
Match: SMESG000049701.1 (SMESG000049701.1)

HSP 1 Score: 236.498 bits (602), Expect = 8.239e-63
Identity = 171/525 (32.57%), Postives = 276/525 (52.57%), Query Frame = 1 
Query:  286 KNSKPIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVNN-SFNGFWEERDIM---AKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELED-FSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCIRTK-NGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYP---DDKPAKPEFIDFMSKILTEPTERMDITGI---KSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTYNFLAHAK------------GKSTGIEGNI--SNLTELETKLSEAELAKQQLSLKLDNT-TNELGKTQKKLSDAVRE--LKDREQLINTNKSEYESSIDNNKLLKAKIENISKLIESS---NREIEQLKS----VIGEKENLLKSLK--TENCN 1746
            K+ K +  F+       +KI  LR+  SDF  I+ +G+G FG+V +VR K    +YAMK + K   +       F EERD++    K  S W+ +  Y F D   LY VM++  GGD+   +++  D   +E T FY  E+V++++V+H +G++HRD+KPDN+LLD  GH+ LADFG+C++ + NG   T   VGTPDYI PEILR+   H    G E DWW+ GIVI+E+ YGE PF  E  S  Y  IM +++    P   DD   + E  D + +++ +   R+   GI   K+HP+      + ++ ++R + +P I EVS  +DT+   +D     N        ++ F G +L   GFTF +   +N +   +            G    + GN   SN   L  ++++ ++   QL  +L+   TN +   Q+  S  V +  + D+E+L+ T    Y+ S      L+ K + I  LIE++   N++ ++L S    ++ +K+++ + LK  TEN N
Sbjct:   52 KDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHG-PYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAE--DLIKQLICKKECRLGNKGIDDFKNHPFFR----EIDWDNLRSYNAPFIPEVSSAEDTSNFEFD---DFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSV---QRIFSHPVYQQLVTDKEKLL-TQCQNYDYS------LREKEQKIDDLIETNRLLNKDRDELTSDRLQILQKKQDIEEDLKVMTENFN 556
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BLAST of Rho-associated kinase vs. Planmine SMEST
Match: SMESG000068357.1 (SMESG000068357.1)

HSP 1 Score: 216.853 bits (551), Expect = 3.752e-60
Identity = 120/382 (31.41%), Postives = 195/382 (51.05%), Query Frame = 1 
Query:  340 KIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKNVYAMKIMDKSTFVN-NSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYIVMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLKPDNMLLDKNGHMKLADFGTCI------RT-----------------------------KNGKVKTNFQVGTPDYICPEILRNTGIHDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYPDDKPAKPEFIDFMSKILTEPTERM----DITGIKSHPYLTNSGYKWNFSDIREHQSPVIFEVSGEDDTNYITYDPXXXXXXXXXXXXXXXXXXGENLAFSGFTFNRFNTY 1365
            ++ + R+ + DFA ++ +G+G FG V LV+ K    +YAMKI+ K   +  +       ERDI+AK  + W++K F++F D   LY+VME++PGGD+   + +L+  S+EQ+ FY  E  LA++ +H+MGFIHRD+KPDN+LLD  GH+KL+DFG C       RT                             KN +      VGTPDYI PE+ +  G          DWW+ G++++E+  G  PF  ++    Y+ +M ++  L++P D P      + +++ L E  +R+     I  IK+  +    G  W    IRE  + +   V+  DDT+     P+   +   N+  +      + LAF  +T+  F+ +
Sbjct:   87 RLKRARLVVDDFAALRVIGKGAFGEVRLVQKKDNGRIYAMKILRKVDMLQKDQIAHVRAERDILAKADNPWVVKMFFSFQDSTNLYLVMEFLPGGDMMTLLMKLDTLSEEQSQFYVAETALAIDSIHSMGFIHRDIKPDNLLLDAKGHIKLSDFGLCTGLKKSHRTEFYKDLSQAKPCDFAQSPLDSKRRAESWRKNRRNLAYSTVGTPDYIAPEVFQQKGYTS-----SCDWWSLGVIMFEMLIGYPPFCSDTPGETYKKVMAFRDHLVFPPDTPISDVSKEVITEFLEEGNKRLGFNSGIVEIKNKSFF--HGVDWEH--IRERPAAIPVIVNSIDDTSNFDDFPDADLSWNINHIQDRENRYKKELAFINYTYKAFDDW 459
The following BLAST results are available for this feature:
BLAST of Rho-associated kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ROCK15.068e-9035.92Rho associated coiled-coil containing protein kina... [more]
ROCK15.809e-8935.92Rho associated coiled-coil containing protein kina... [more]
ROCK21.036e-8837.24Rho associated coiled-coil containing protein kina... [more]
ROCK24.540e-8641.60Rho associated coiled-coil containing protein kina... [more]
CDC42BPG7.362e-7429.97CDC42 binding protein kinase gamma [Source:HGNC Sy... [more]
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BLAST of Rho-associated kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mrck-15.754e-7231.45Serine/threonine-protein kinase mrck-1 [Source:Un... [more]
mrck-15.754e-7231.45Serine/threonine-protein kinase mrck-1 [Source:Un... [more]
mrck-18.744e-7231.39Serine/threonine-protein kinase mrck-1 [Source:Un... [more]
mrck-18.744e-7231.39Serine/threonine-protein kinase mrck-1 [Source:Un... [more]
sax-15.582e-6232.11Serine/threonine-protein kinase sax-1 [Source:Uni... [more]
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BLAST of Rho-associated kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Rok3.204e-8741.21gene:FBgn0026181 transcript:FBtr0340151[more]
Rok3.386e-8741.21gene:FBgn0026181 transcript:FBtr0340153[more]
Rok3.721e-8741.21gene:FBgn0026181 transcript:FBtr0074286[more]
Rok3.854e-8741.21gene:FBgn0026181 transcript:FBtr0340152[more]
gek1.677e-6838.13gene:FBgn0023081 transcript:FBtr0072287[more]
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BLAST of Rho-associated kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rock11.235e-9036.50Rho-associated, coiled-coil containing protein kin... [more]
rock2a4.392e-8928.83rho-associated, coiled-coil containing protein kin... [more]
rock2a5.218e-8928.83rho-associated, coiled-coil containing protein kin... [more]
rock2b5.387e-8733.57rho-associated, coiled-coil containing protein kin... [more]
rock2b6.072e-8733.57rho-associated, coiled-coil containing protein kin... [more]
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BLAST of Rho-associated kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ROCK11.421e-8835.16Rho-associated, coiled-coil containing protein kin... [more]
ROCK12.283e-8835.16Rho-associated, coiled-coil containing protein kin... [more]
ROCK13.181e-8835.16Rho-associated, coiled-coil containing protein kin... [more]
med186.008e-8837.40mediator complex subunit 18 [Source:Xenbase;Acc:XB... [more]
med182.831e-8737.30mediator complex subunit 18 [Source:Xenbase;Acc:XB... [more]
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BLAST of Rho-associated kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Rock14.482e-9337.75Rho-associated coiled-coil containing protein kina... [more]
Rock11.355e-9035.92Rho-associated coiled-coil containing protein kina... [more]
Rock21.502e-8737.05Rho-associated coiled-coil containing protein kina... [more]
Rock23.432e-8737.05Rho-associated coiled-coil containing protein kina... [more]
Rock18.867e-8736.12Rho-associated coiled-coil containing protein kina... [more]
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BLAST of Rho-associated kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P70335|ROCK1_MOUSE9.475e-9035.92Rho-associated protein kinase 1 OS=Mus musculus OX... [more]
sp|Q63644|ROCK1_RAT1.016e-8932.08Rho-associated protein kinase 1 OS=Rattus norvegic... [more]
sp|A8WVU9|ROCK_CAEBR4.065e-8936.67Rho-associated protein kinase let-502 OS=Caenorhab... [more]
sp|O77819|ROCK1_RABIT4.847e-8936.29Rho-associated protein kinase 1 OS=Oryctolagus cun... [more]
sp|Q13464|ROCK1_HUMAN2.790e-8835.92Rho-associated protein kinase 1 OS=Homo sapiens OX... [more]
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BLAST of Rho-associated kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
I0AYW10.000e+099.84Rho-associated kinase OS=Schmidtea mediterranea OX... [more]
A0A183UG063.859e-12128.56Uncharacterized protein OS=Toxocara canis OX=6265 ... [more]
A0A158N7Z81.279e-11428.43Uncharacterized protein OS=Onchocerca volvulus OX=... [more]
A0A0K0JJA52.597e-11328.35BMA-LET-502 OS=Brugia malayi OX=6279 GN=bma-let-50... [more]
A0A4E9FNU62.597e-11328.35Uncharacterized protein OS=Brugia malayi OX=6279 G... [more]
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BLAST of Rho-associated kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rock2a1.540e-8929.43rho-associated protein kinase 2 [Source:NCBI gene;... [more]
rock2a1.694e-8929.47rho-associated protein kinase 2 [Source:NCBI gene;... [more]
rock2a1.533e-8629.50rho-associated protein kinase 2 [Source:NCBI gene;... [more]
rock2a2.404e-8629.33rho-associated protein kinase 2 [Source:NCBI gene;... [more]
ROCK13.707e-8642.06Rho associated coiled-coil containing protein kina... [more]
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BLAST of Rho-associated kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000003561.15.424e-8839.53pep scaffold:Pmarinus_7.0:GL478057:5187:43749:1 ge... [more]
ENSPMAT00000004595.11.347e-8732.93pep scaffold:Pmarinus_7.0:GL477044:11103:63873:-1 ... [more]
ENSPMAT00000006413.19.141e-7741.64pep scaffold:Pmarinus_7.0:GL485553:3974:11158:-1 g... [more]
ENSPMAT00000002084.14.818e-7431.59pep scaffold:Pmarinus_7.0:GL476486:6827:40506:-1 g... [more]
ENSPMAT00000005559.11.734e-6437.64pep scaffold:Pmarinus_7.0:GL476474:6865:57025:1 ge... [more]
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BLAST of Rho-associated kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
DBF27.415e-5131.79Ser/Thr kinase involved in transcription and stres... [more]
DBF205.043e-4830.26Ser/Thr kinase involved in late nuclear division; ... [more]
YPK21.546e-4733.57Protein kinase similar to S/T protein kinase Ypk1p... [more]
FPK13.838e-4731.94Ser/Thr protein kinase; phosphorylates several ami... [more]
TPK26.674e-4733.44cAMP-dependent protein kinase catalytic subunit; p... [more]
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BLAST of Rho-associated kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO376771.738e-7036.29Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO320089.102e-7046.50Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO427001.339e-5832.55Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO355852.316e-4741.03Protein kinase C [Source:UniProtKB/TrEMBL;Acc:A7S... [more]
EDO360346.737e-4428.38Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Rho-associated kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rock15.286e-8935.46Rho associated coiled-coil containing protein kina... [more]
rock2b2.685e-8837.53rho-associated protein kinase 2 [Source:NCBI gene;... [more]
rock11.710e-8744.18Rho associated coiled-coil containing protein kina... [more]
rock2a4.883e-7929.12rho-associated protein kinase 2 [Source:NCBI gene;... [more]
rock2a5.210e-7929.12rho-associated protein kinase 2 [Source:NCBI gene;... [more]
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BLAST of Rho-associated kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000057753.10.000e+0100.00SMESG000057753.1[more]
SMESG000041847.13.557e-8640.05SMESG000041847.1[more]
SMESG000049701.16.439e-6332.57SMESG000049701.1[more]
SMESG000049701.18.239e-6332.57SMESG000049701.1[more]
SMESG000068357.13.752e-6031.41SMESG000068357.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30016875
GenBankAFH54449.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30016875 ID=SMED30016875|Name=Rho-associated kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=3891bp
TTCAAATTTAATCGAGTTTTAATTTATTTCCTATTTAATACTTAATTTAA
TTTAATAAATTACGCATTAAATTGTAATATATGACAATATATACTTACCG
ACAGTTTTAGATTAAAATATAATCTCTAAAAACAAAGTGCCTTAGAGATG
AATTCTGAAGACATTGTAAATAAACTGTCGTTGATTGAAAATGAAATTTT
TAATCCCTCCTCTGATCTATATTTGGATAATTTACTCGACTTAGCATCGT
CTATCTCATACGATATTCACTGTAGCGGAACATGGAAAAATTCCAAACCA
ATTAAAGCATTTTTAGATCGATTTTCTAATTTTTCCGAAAAAATCTACAA
ATTACGAGTATCATTGAGTGATTTTGCTGTCATTAAAACTGTTGGGCAAG
GTGGGTTTGGTCGAGTGGATTTAGTGAGACACAAATCGACGAAAAATGTC
TATGCAATGAAAATTATGGATAAAAGCACATTTGTCAACAATTCCTTTAA
TGGATTTTGGGAAGAACGAGATATTATGGCTAAAAATTCTAGCGATTGGT
TAATAAAATGTTTTTATACTTTTATGGATTTGAAAAAGCTTTACATTGTG
ATGGAATACATGCCAGGTGGTGACCTTTACCACTGGATGACTGAATTGGA
AGACTTTAGTGATGAACAAACACATTTTTATGCCATGGAATTGGTATTAG
CAGTTGAGGTGTTGCACAATATGGGTTTCATTCATCGCGACTTGAAACCC
GACAATATGTTATTGGACAAGAACGGCCACATGAAATTAGCCGATTTCGG
TACCTGTATTCGAACGAAAAACGGAAAGGTGAAAACAAATTTCCAAGTTG
GTACTCCGGATTATATTTGCCCGGAAATTCTTCGAAATACTGGCATACAT
GATCTTGAAGTCGGATTTGAGACTGATTGGTGGGCATTTGGCATTGTGAT
ATATGAATTGTTTTACGGTGAAACTCCATTCGAAGGAGAATCGACGTCGA
CTTTGTATCAAAATATCATGAGATATAAAAGCACTCTCATTTATCCTGAC
GATAAGCCTGCAAAGCCAGAATTTATTGATTTCATGTCGAAAATTTTAAC
CGAGCCAACAGAACGGATGGATATTACCGGAATCAAGTCTCATCCGTATT
TGACCAACAGTGGATACAAATGGAATTTCAGTGATATCCGAGAGCATCAA
TCACCGGTGATTTTCGAAGTTTCCGGTGAAGACGACACAAATTACATAAC
ATATGATCCCAATGATAGACGAAACAATATCTCCAACAATTTCATCAATA
ATAACTATTTCAGTGGCGAGAATCTAGCATTCTCTGGATTTACGTTCAAT
CGCTTTAACACCTATAACTTCTTGGCACACGCTAAAGGAAAATCTACGGG
AATCGAAGGGAATATTTCCAATCTAACAGAATTGGAAACGAAACTCTCGG
AAGCAGAATTAGCCAAACAACAGTTATCGTTGAAACTAGACAACACAACA
AACGAACTGGGAAAAACCCAAAAGAAACTTTCCGATGCGGTTAGGGAACT
GAAGGACCGAGAACAATTGATCAATACGAACAAATCCGAGTATGAAAGCA
GCATCGACAACAACAAATTGTTGAAAGCAAAAATAGAAAATATTTCCAAA
CTAATCGAATCGTCAAATCGAGAAATCGAGCAACTGAAATCAGTGATAGG
AGAGAAAGAAAACTTGTTAAAAAGTTTAAAGACAGAAAATTGTAATCTCT
CCGATGAAATATCCAGTTCAAAGATTAGTTTGAGTACGTTAAAACAAAAT
TTGTCGAAAGCCCATGAGGAAATAGAGGAAAAAAGTTCACAAATTGATAA
TATGAAAAAAATCAACTCGTTGTTTGAGGAAGAAAAATCCAAAAATCAAA
ATTTAATCAATGAAATCAATACGAAAACCAGAAAAATCAACGAATTCGAA
TTGCAGTTAGAACTGATCAGTAGTCGAGCTAAAGATAATGTATTATTGGA
TAGCAATTTACAGAGTGCACCGGTTAAAAGTGAGGATTTGGAATTACTGC
AGAAAGAAAAGCAGGCGTTAGAATCACGTTTGATTAGTATGATGAATGAT
TTGAGTAGCATGGAGGAAGAGAAAAATGCTTTACAGCATGATTTGAACAA
TGAAAAAATACAGAAATCGGAATTGGAAACTATTCGAGATAAATTGTCAA
AAGACGTCACTAATCAGAAACTCAAAGTTTCAAGCTTACAAAACCGACTT
AACGCAGCAGAAGATCAAAAACGAGTTCTGAATCAACGAATCAATATGAT
TGAAAGTGAAAAGGATCAAATTGAACAACAGAAGAAAATGTTCGAGTCGA
TGGTTGAAGTTCGAAAAGCAGAACTCGATGAAATTGTTGCTCAACTCGAA
GAGCAAGAAGAATGCTTTTTGGAAAAAGAAAAAAAATTTGAAAACGATAA
AAAGTTCCTAGAAACAAATTCAATGAATATTTCCATGGAAAATGATAGAC
TTAAAGCTGAACTAGTTGAAGTCAACAAGAAACTAGAAGACTTGAAATTG
ATTGAATATGAAAACGGCTCACTGTGTATGATTAATCAGAAAATGAAAAT
TGATTTGGAAGAAAAGAAACAACAGATTATGGACATGACCAAAGAGAAAA
TGGTTCTCACAAATGATTTGGACAAAGTTCAGAAAGAATTACAAAGTGAT
AAGTTAAAAATTAAATCTCTCGTAACGAAAATCGATGAAATGATGACCAA
TCCGAAATCCATGCCTCAATTGAGTTCGAGAAAAAAGAAAGAAAAAACTG
ACAATGATTCTATCAGGAAGATCAGGCAACTGGAAACGGACCTGTCGAAA
GAGAAAGTGAAATTCCAGGAAAAACTAAAGGAATGCAACGACACAAAAAA
TGAATGTCAAACTTGGCAAGATCAATGCAAAGAACTGAAATCGGAATTAG
AAGATAAAAATAACATCATCAAAGATTTAATGAAGAGTCTCAATAATGAC
ATGATTCCAAAAGAAAGTCCTTCTGATGAGCTGTCGATTAAGGATAATGA
AATGAAAAGTCTCGAAGGGAAATTGGAGATGCTGAAGAAAGGCAAAGGTA
AACATAAGATCAGTTGGTTACCGTATTTTGCGGTTTTAAAACCATTCAAA
TTGGAACTCTATCAAGGAGAGAACGATAATGTACCTTTTCACTCAATTGA
CTTGAGATCTGTAATGCATATTCGAGAGCCGTCAGCAGCGGAATGCGTAC
ATGTAGATAAAAATCTTTTGCCGCAAATTCTTCAGATAATTTACCAGAAG
CCAGACACCGGTGATGATTTCCGCCGGCAATCTGTTATATCAGTAGACTC
GAATCGACGTTTTAAAAGTTCAACTCTAACTGTTGATGATGGAAGATCCT
CCACCCGTTCATCGATGATTGTGGACGCCCAACCAAATGGACCGATTAAT
GTGGAGAATCATTCATTTGTACCTATGCGATTCAGATCAATCACAACCTG
TGATCTGTGCCACCAATCATGCTCAGATTGGTTAAATCCTCCGCCTGCTC
TTGAATGTGGAAATTGCAAGAAACGAATCCATCAGGAGCACTTGTTGTCA
GGTGAATACAAAATTCAGTGGTGTCCAGATGCAATAGAAATCTTTTTATT
CAAAGTCGAATCGAAAGAAGCGAAAAATGCTTGGATAAGTTGTCTGAACA
GTTTGAAGGAATATCAGAAAAAAGCCGAAATCCAAATCGCACCAAACACA
TATTATCGTAGTGTTCGTGTACCGGGTCGTCATTCACCCGCAATTTAATC
ATTCCATATGTACAATTTTATATCAAAAGGAAAATTATTTTCAACTAACA
TCCTCTATTTTTGAAGCTTTATTTTTTCAATATCTTTCATT
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protein sequence of SMED30016875-orf-1

>SMED30016875-orf-1 ID=SMED30016875-orf-1|Name=SMED30016875-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1217bp
MNSEDIVNKLSLIENEIFNPSSDLYLDNLLDLASSISYDIHCSGTWKNSK
PIKAFLDRFSNFSEKIYKLRVSLSDFAVIKTVGQGGFGRVDLVRHKSTKN
VYAMKIMDKSTFVNNSFNGFWEERDIMAKNSSDWLIKCFYTFMDLKKLYI
VMEYMPGGDLYHWMTELEDFSDEQTHFYAMELVLAVEVLHNMGFIHRDLK
PDNMLLDKNGHMKLADFGTCIRTKNGKVKTNFQVGTPDYICPEILRNTGI
HDLEVGFETDWWAFGIVIYELFYGETPFEGESTSTLYQNIMRYKSTLIYP
DDKPAKPEFIDFMSKILTEPTERMDITGIKSHPYLTNSGYKWNFSDIREH
QSPVIFEVSGEDDTNYITYDPNDRRNNISNNFINNNYFSGENLAFSGFTF
NRFNTYNFLAHAKGKSTGIEGNISNLTELETKLSEAELAKQQLSLKLDNT
TNELGKTQKKLSDAVRELKDREQLINTNKSEYESSIDNNKLLKAKIENIS
KLIESSNREIEQLKSVIGEKENLLKSLKTENCNLSDEISSSKISLSTLKQ
NLSKAHEEIEEKSSQIDNMKKINSLFEEEKSKNQNLINEINTKTRKINEF
ELQLELISSRAKDNVLLDSNLQSAPVKSEDLELLQKEKQALESRLISMMN
DLSSMEEEKNALQHDLNNEKIQKSELETIRDKLSKDVTNQKLKVSSLQNR
LNAAEDQKRVLNQRINMIESEKDQIEQQKKMFESMVEVRKAELDEIVAQL
EEQEECFLEKEKKFENDKKFLETNSMNISMENDRLKAELVEVNKKLEDLK
LIEYENGSLCMINQKMKIDLEEKKQQIMDMTKEKMVLTNDLDKVQKELQS
DKLKIKSLVTKIDEMMTNPKSMPQLSSRKKKEKTDNDSIRKIRQLETDLS
KEKVKFQEKLKECNDTKNECQTWQDQCKELKSELEDKNNIIKDLMKSLNN
DMIPKESPSDELSIKDNEMKSLEGKLEMLKKGKGKHKISWLPYFAVLKPF
KLELYQGENDNVPFHSIDLRSVMHIREPSAAECVHVDKNLLPQILQIIYQ
KPDTGDDFRRQSVISVDSNRRFKSSTLTVDDGRSSTRSSMIVDAQPNGPI
NVENHSFVPMRFRSITTCDLCHQSCSDWLNPPPALECGNCKKRIHQEHLL
SGEYKIQWCPDAIEIFLFKVESKEAKNAWISCLNSLKEYQKKAEIQIAPN
TYYRSVRVPGRHSPAI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0002032epidermal cell
PLANA:0002142parenchyma
PLANA:0003116parenchymal cell
PLANA:0003117parapharyngeal cell
Vocabulary: INTERPRO
TermDefinition
IPR029875LET-502
IPR002219PE/DAG-bd
IPR001849PH_domain
IPR000719Prot_kinase_dom
IPR011993PH-like_dom_sf
IPR008271Ser/Thr_kinase_AS
IPR000961AGC-kinase_C
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0004674protein serine/threonine kinase activity
GO:0000166nucleotide binding
GO:0016301kinase activity
GO:0016740transferase activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
GO:0035556intracellular signal transduction
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 740..767
NoneNo IPR availableCOILSCoilCoilcoord: 892..951
NoneNo IPR availableCOILSCoilCoilcoord: 426..467
NoneNo IPR availableCOILSCoilCoilcoord: 545..603
NoneNo IPR availableCOILSCoilCoilcoord: 782..802
NoneNo IPR availableCOILSCoilCoilcoord: 813..861
NoneNo IPR availableCOILSCoilCoilcoord: 489..530
NoneNo IPR availableCOILSCoilCoilcoord: 631..735
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 27..400
e-value: 2.5E-125
score: 420.3
NoneNo IPR availableGENE3DG3DSA:3.30.60.20coord: 1094..1160
e-value: 4.1E-11
score: 44.4
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 159..357
e-value: 2.5E-125
score: 420.3
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 866..888
NoneNo IPR availablePANTHERPTHR22988MYOTONIC DYSTROPHY S/T KINASE-RELATEDcoord: 3..605
coord: 630..1187
NoneNo IPR availableSUPERFAMILYSSF50729PH domain-likecoord: 915..1185
NoneNo IPR availableSUPERFAMILYSSF57889Cysteine-rich domaincoord: 1098..1148
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 76..335
e-value: 2.8E-83
score: 292.7
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 77..335
e-value: 6.0E-60
score: 202.8
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 76..335
score: 44.456
IPR001849Pleckstrin homology domainSMARTSM00233PH_updatecoord: 970..1190
e-value: 0.0019
score: 27.4
IPR011993PH-like domain superfamilyGENE3DG3DSA:2.30.29.30coord: 971..1076
e-value: 2.9E-10
score: 42.5
IPR029875Rho-associated protein kinase LET-502PANTHERPTHR22988:SF38RHO-ASSOCIATED PROTEIN KINASEcoord: 630..1187
coord: 3..605
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 194..206
IPR000961AGC-kinase, C-terminalPROSITEPS51285AGC_KINASE_CTERcoord: 338..410
score: 8.381
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domainCDDcd00029C1coord: 1105..1149
e-value: 5.29188E-8
score: 48.2572
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 53..345