Phosphodiesterase

Overview
NamePhosphodiesterase
Smed IDSMED30016840
Length (bp)349
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Phosphodiesterase (SMED30016840) t-SNE clustered cells

Violin plots show distribution of expression levels for Phosphodiesterase (SMED30016840) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Phosphodiesterase (SMED30016840) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Phosphodiesterase (SMED30016840) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30016840

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30016840SMESG000019038.1 dd_Smed_v4_8595_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30016840SMESG000019038.1 dd_Smed_v4_8595_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30016840SMESG000019038.1 dd_Smed_v4_8595_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30016840SMESG000019038.1 dd_Smed_v4_8595_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE5A (phosphodiesterase 5A [Source:HGNC Symbol;Acc:HGNC:8784])

HSP 1 Score: 73.559 bits (179), Expect = 1.426e-16
Identity = 48/99 (48.48%), Postives = 69/99 (69.70%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS   +++L+S+LFDV   S LE+      +NCIR++  +GI+GHVA  GE  NI+DAY+
Sbjct:  102 ELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDS-SNDKFLISRLFDVAEGSTLEE----VSNNCIRLEWNKGIVGHVAALGEPLNIKDAYE 195
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE5A (phosphodiesterase 5A [Source:HGNC Symbol;Acc:HGNC:8784])

HSP 1 Score: 73.559 bits (179), Expect = 6.875e-16
Identity = 48/99 (48.48%), Postives = 69/99 (69.70%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS   +++L+S+LFDV   S LE+      +NCIR++  +GI+GHVA  GE  NI+DAY+
Sbjct:  154 ELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDS-SNDKFLISRLFDVAEGSTLEE----VSNNCIRLEWNKGIVGHVAALGEPLNIKDAYE 247
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE5A (phosphodiesterase 5A [Source:HGNC Symbol;Acc:HGNC:8784])

HSP 1 Score: 73.559 bits (179), Expect = 7.764e-16
Identity = 48/99 (48.48%), Postives = 69/99 (69.70%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS   +++L+S+LFDV   S LE+      +NCIR++  +GI+GHVA  GE  NI+DAY+
Sbjct:  102 ELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDS-SNDKFLISRLFDVAEGSTLEE----VSNNCIRLEWNKGIVGHVAALGEPLNIKDAYE 195
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE5A (phosphodiesterase 5A [Source:HGNC Symbol;Acc:HGNC:8784])

HSP 1 Score: 73.1738 bits (178), Expect = 8.238e-16
Identity = 48/99 (48.48%), Postives = 69/99 (69.70%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS   +++L+S+LFDV   S LE+      +NCIR++  +GI+GHVA  GE  NI+DAY+
Sbjct:  112 ELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDS-SNDKFLISRLFDVAEGSTLEE----VSNNCIRLEWNKGIVGHVAALGEPLNIKDAYE 205
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE11A (phosphodiesterase 11A [Source:HGNC Symbol;Acc:HGNC:8773])

HSP 1 Score: 70.4774 bits (171), Expect = 7.104e-15
Identity = 51/110 (46.36%), Postives = 71/110 (64.55%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E +F  EL+KD+S+DLDLTSL +KIL  V L+++ADRCSLFL+E  +  K + LVSK FDV   + L         N +++  G+GI+G+V   GE  NI DAY+
Sbjct:  196 LKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGK-KTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQ 304
[Close]
BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-5 (Probable 3',5'-cyclic phosphodiesterase pde-5 [Source:UniProtKB/Swiss-Prot;Acc:P91119])

HSP 1 Score: 47.7506 bits (112), Expect = 2.712e-7
Identity = 29/84 (34.52%), Postives = 45/84 (53.57%), Query Frame = 1 
Query:   97 VFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            + K++     L++ADR SLFL++     K   + +++FDV         V       IR  + +GI G+VA TGE  NIE+AY+
Sbjct:  219 IIKVMNFAQKLVDADRASLFLVD----SKNAQIYARIFDVGTGDEEHVRVNSEGQKEIRFDMSKGIAGYVASTGEGLNIENAYE 298
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0343831)

HSP 1 Score: 84.3445 bits (207), Expect = 4.869e-20
Identity = 57/121 (47.11%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIE-----EDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            R  R+  K LDE E + EL+KD+ ++L++ +L  KILQNVS+LL ADR SLFL++      D +KK   LVSKLFDV   S +E+  ++   + +R+  G GI GHVA +GE  NI DAY+
Sbjct:  348 RLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKK--CLVSKLFDVCPRSTVEEMEQQ---DEVRVAWGTGIAGHVAESGEPVNIPDAYQ 463
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0112545)

HSP 1 Score: 84.3445 bits (207), Expect = 4.869e-20
Identity = 57/121 (47.11%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIE-----EDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            R  R+  K LDE E + EL+KD+ ++L++ +L  KILQNVS+LL ADR SLFL++      D +KK   LVSKLFDV   S +E+  ++   + +R+  G GI GHVA +GE  NI DAY+
Sbjct:  348 RLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKK--CLVSKLFDVCPRSTVEEMEQQ---DEVRVAWGTGIAGHVAESGEPVNIPDAYQ 463
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0112544)

HSP 1 Score: 84.3445 bits (207), Expect = 5.585e-20
Identity = 57/121 (47.11%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIE-----EDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            R  R+  K LDE E + EL+KD+ ++L++ +L  KILQNVS+LL ADR SLFL++      D +KK   LVSKLFDV   S +E+  ++   + +R+  G GI GHVA +GE  NI DAY+
Sbjct:  392 RLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKK--CLVSKLFDVCPRSTVEEMEQQ---DEVRVAWGTGIAGHVAESGEPVNIPDAYQ 507
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0343830)

HSP 1 Score: 84.3445 bits (207), Expect = 5.585e-20
Identity = 57/121 (47.11%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIE-----EDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            R  R+  K LDE E + EL+KD+ ++L++ +L  KILQNVS+LL ADR SLFL++      D +KK   LVSKLFDV   S +E+  ++   + +R+  G GI GHVA +GE  NI DAY+
Sbjct:  392 RLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKK--CLVSKLFDVCPRSTVEEMEQQ---DEVRVAWGTGIAGHVAESGEPVNIPDAYQ 507
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0303163)

HSP 1 Score: 83.5741 bits (205), Expect = 1.047e-19
Identity = 57/121 (47.11%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIE-----EDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            R  R+  K LDE E + EL+KD+ ++L++ +L  KILQNVS+LL ADR SLFL++      D +KK   LVSKLFDV   S +E+  ++   + +R+  G GI GHVA +GE  NI DAY+
Sbjct:  348 RLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKK--CLVSKLFDVCPRSTVEEMEQQ---DEVRVAWGTGIAGHVAESGEPVNIPDAYQ 463
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde11al (phosphodiesterase 11a, like [Source:ZFIN;Acc:ZDB-GENE-031118-106])

HSP 1 Score: 77.0258 bits (188), Expect = 2.526e-17
Identity = 50/110 (45.45%), Postives = 73/110 (66.36%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E EF  EL+KD+S++LD+T+L +KIL NV +++ ADRCSLFL+E  S K  R LVSK FDV + + +  S      N +++  G+GI+G+VA  GE  N  +AY+
Sbjct:  153 LKESNEREFFLELVKDISNELDMTNLSYKILINVCIMVNADRCSLFLVEGPSHK--RTLVSKFFDVHSGTTVRPSSSTLDSNEVQVPWGKGIIGYVAEHGETVNTPNAYE 260
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde11a (phosphodiesterase 11a [Source:ZFIN;Acc:ZDB-GENE-070912-207])

HSP 1 Score: 71.2478 bits (173), Expect = 2.565e-15
Identity = 52/110 (47.27%), Postives = 74/110 (67.27%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E EF  EL+KD+S+DLDLTSL +KIL  V ++++ADRCSLFL+E  + KK   LVSK FDV   + +  S+    +  +++  G+GI+G+VA  GE  NI DAY+
Sbjct:  149 LKEHNEREFFLELVKDISNDLDLTSLSYKILVFVCIMVDADRCSLFLVEGPTNKKT--LVSKFFDVHAGTTVLPSLSNSDE--VQVPWGKGIIGYVAEHGETVNIPDAYQ 254
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde11a (phosphodiesterase 11a [Source:ZFIN;Acc:ZDB-GENE-070912-207])

HSP 1 Score: 68.5514 bits (166), Expect = 2.790e-14
Identity = 52/110 (47.27%), Postives = 74/110 (67.27%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E EF  EL+KD+S+DLDLTSL +KIL  V ++++ADRCSLFL+E  + KK   LVSK FDV   + +  S+    +  +++  G+GI+G+VA  GE  NI DAY+
Sbjct:  149 LKEHNEREFFLELVKDISNDLDLTSLSYKILVFVCIMVDADRCSLFLVEGPTNKKT--LVSKFFDVHAGTTVLPSLSNSDE--VQVPWGKGIIGYVAEHGETVNIPDAYQ 254
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde5ab (phosphodiesterase 5A, cGMP-specific, b [Source:ZFIN;Acc:ZDB-GENE-060824-4])

HSP 1 Score: 65.855 bits (159), Expect = 1.908e-13
Identity = 37/82 (45.12%), Postives = 56/82 (68.29%), Query Frame = 1 
Query:  103 KILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            KI  +   L+ ADR SLFL+ EDS  + ++LVS+LFDV   S LE+S     ++ IR++  +GI+G+VA TG+  NI++AY+
Sbjct:  170 KIFLHTHELIAADRYSLFLVGEDSSNR-KFLVSRLFDVAEGSTLEES----SNSGIRLEWNKGIVGYVAATGQPLNIKNAYE 246
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde5ab (phosphodiesterase 5A, cGMP-specific, b [Source:ZFIN;Acc:ZDB-GENE-060824-4])

HSP 1 Score: 65.855 bits (159), Expect = 1.909e-13
Identity = 37/82 (45.12%), Postives = 56/82 (68.29%), Query Frame = 1 
Query:  103 KILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            KI  +   L+ ADR SLFL+ EDS  + ++LVS+LFDV   S LE+S     ++ IR++  +GI+G+VA TG+  NI++AY+
Sbjct:  170 KIFLHTHELIAADRYSLFLVGEDSSNR-KFLVSRLFDVAEGSTLEES----SNSGIRLEWNKGIVGYVAATGQPLNIKNAYE 246
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: ENSXETT00000053056.1 (phosphodiesterase 11A [Source:NCBI gene;Acc:100379882])

HSP 1 Score: 73.9442 bits (180), Expect = 4.619e-16
Identity = 51/110 (46.36%), Postives = 72/110 (65.45%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E  F  EL+KD+S++L+LTSL +KIL  V ++++ADRCSLFL+E  + KK   LVSK FDV   + L  S      N +++  G+GI+G+VA  GE  NI DAY+
Sbjct:  152 LKEHNERAFFLELVKDISNELNLTSLCYKILIFVCIMVDADRCSLFLVEGTANKKS--LVSKFFDVHAGTTLLPSCSTENSNEVQVPWGKGIIGYVAEHGETVNIPDAYQ 259
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: pde5a (phosphodiesterase 5A [Source:NCBI gene;Acc:780273])

HSP 1 Score: 71.2478 bits (173), Expect = 4.493e-15
Identity = 47/99 (47.47%), Postives = 70/99 (70.71%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS  K ++LVS+LFDV   +    +V++  +NCIR++  +GI+GHVA  G+  NI+DAY+
Sbjct:  137 ELVKDISSHLDVTTLCHKIFLHIHELIAADRYSLFLVCEDSSNK-KFLVSRLFDVAEGT----TVEQASNNCIRLEWNKGIVGHVAEFGQPLNIKDAYQ 230
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: pde5a (phosphodiesterase 5A [Source:NCBI gene;Acc:780273])

HSP 1 Score: 71.2478 bits (173), Expect = 4.581e-15
Identity = 47/99 (47.47%), Postives = 70/99 (70.71%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS  K ++LVS+LFDV   +    +V++  +NCIR++  +GI+GHVA  G+  NI+DAY+
Sbjct:   97 ELVKDISSHLDVTTLCHKIFLHIHELIAADRYSLFLVCEDSSNK-KFLVSRLFDVAEGT----TVEQASNNCIRLEWNKGIVGHVAEFGQPLNIKDAYQ 190
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: pde5a (phosphodiesterase 5A [Source:NCBI gene;Acc:780273])

HSP 1 Score: 70.8626 bits (172), Expect = 4.671e-15
Identity = 47/99 (47.47%), Postives = 70/99 (70.71%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS  K ++LVS+LFDV   +    +V++  +NCIR++  +GI+GHVA  G+  NI+DAY+
Sbjct:  134 ELVKDISSHLDVTTLCHKIFLHIHELIAADRYSLFLVCEDSSNK-KFLVSRLFDVAEGT----TVEQASNNCIRLEWNKGIVGHVAEFGQPLNIKDAYQ 227
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: pde5a (phosphodiesterase 5A [Source:NCBI gene;Acc:780273])

HSP 1 Score: 70.8626 bits (172), Expect = 4.783e-15
Identity = 47/99 (47.47%), Postives = 70/99 (70.71%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS  K ++LVS+LFDV   +    +V++  +NCIR++  +GI+GHVA  G+  NI+DAY+
Sbjct:  134 ELVKDISSHLDVTTLCHKIFLHIHELIAADRYSLFLVCEDSSNK-KFLVSRLFDVAEGT----TVEQASNNCIRLEWNKGIVGHVAEFGQPLNIKDAYQ 227
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde5a (phosphodiesterase 5A, cGMP-specific [Source:MGI Symbol;Acc:MGI:2651499])

HSP 1 Score: 75.8702 bits (185), Expect = 6.549e-17
Identity = 49/99 (49.49%), Postives = 71/99 (71.72%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS  K+++L+S+LFDV   S LE++     +NCIR++  +GI+GHVA  GE  NI+DAY+
Sbjct:  112 ELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDS-SKDKFLISRLFDVAEGSTLEEA----SNNCIRLEWNKGIVGHVAAFGEPLNIKDAYE 205
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde5a (phosphodiesterase 5A, cGMP-specific [Source:MGI Symbol;Acc:MGI:2651499])

HSP 1 Score: 75.8702 bits (185), Expect = 6.894e-17
Identity = 49/99 (49.49%), Postives = 71/99 (71.72%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS  K+++L+S+LFDV   S LE++     +NCIR++  +GI+GHVA  GE  NI+DAY+
Sbjct:  144 ELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDS-SKDKFLISRLFDVAEGSTLEEA----SNNCIRLEWNKGIVGHVAAFGEPLNIKDAYE 237
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde11a (phosphodiesterase 11A [Source:MGI Symbol;Acc:MGI:3036251])

HSP 1 Score: 67.3958 bits (163), Expect = 6.456e-14
Identity = 51/110 (46.36%), Postives = 71/110 (64.55%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E +F  EL+KD+S+DLDLTSL +KIL  V L+++ADRCSLFL+E  +  K + LVSK FDV   + L         N +++  G+GI+G+V   GE  NI DAY+
Sbjct:  196 LKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGK-KTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQ 304
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde6b (phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide [Source:MGI Symbol;Acc:MGI:97525])

HSP 1 Score: 55.4546 bits (132), Expect = 1.109e-9
Identity = 37/104 (35.58%), Postives = 65/104 (62.50%), Query Frame = 1 
Query:   28 LDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIED 339
            ++E   + EL++D+ + +++  +VFKIL+ +  +L ADRCSLF+  + +   E  L ++LF V  +S+LED +    D+ I   +  GI+GHVA T +  N++D
Sbjct:   53 VEESAALFELVQDMQESVNMERVVFKILRRLCTILHADRCSLFMYRQRNGIAE--LATRLFSVQPDSLLEDCLVP-PDSEIVFPLDIGIVGHVAQTKKMINVQD 153
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde10a (phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1345143])

HSP 1 Score: 52.7582 bits (125), Expect = 9.522e-9
Identity = 32/73 (43.84%), Postives = 42/73 (57.53%), Query Frame = 1 
Query:  127 LLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            L+ ADRC+LF ++     K + L S LFD+  E   +   KK K+  IR  + +GI G VA TGE  NI DAY
Sbjct:  222 LVNADRCALFQVDH----KNKELYSDLFDIGEEKEGKPIFKKTKE--IRFSIEKGIAGQVARTGEVLNIPDAY 288
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q9VJ79|PDE11_DROME (Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster OX=7227 GN=Pde11 PE=1 SV=4)

HSP 1 Score: 84.3445 bits (207), Expect = 5.599e-19
Identity = 57/121 (47.11%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIE-----EDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            R  R+  K LDE E + EL+KD+ ++L++ +L  KILQNVS+LL ADR SLFL++      D +KK   LVSKLFDV   S +E+  ++   + +R+  G GI GHVA +GE  NI DAY+
Sbjct:  392 RLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKK--CLVSKLFDVCPRSTVEEMEQQ---DEVRVAWGTGIAGHVAESGEPVNIPDAYQ 507
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|O54735|PDE5A_RAT (cGMP-specific 3',5'-cyclic phosphodiesterase OS=Rattus norvegicus OX=10116 GN=Pde5a PE=2 SV=1)

HSP 1 Score: 76.6406 bits (187), Expect = 2.988e-16
Identity = 50/99 (50.51%), Postives = 71/99 (71.72%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS  K+++LVS+LFDV   S LE++     +NCIR++  +GI+GHVA  GE  NI+DAY+
Sbjct:  112 ELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDS-SKDKFLVSRLFDVAEGSTLEEA----SNNCIRLEWNKGIVGHVAAFGEPLNIKDAYE 205
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q8CG03|PDE5A_MOUSE (cGMP-specific 3',5'-cyclic phosphodiesterase OS=Mus musculus OX=10090 GN=Pde5a PE=1 SV=2)

HSP 1 Score: 75.8702 bits (185), Expect = 4.823e-16
Identity = 49/99 (49.49%), Postives = 71/99 (71.72%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+T+L  KI  ++  L+ ADR SLFL+ EDS  K+++L+S+LFDV   S LE++     +NCIR++  +GI+GHVA  GE  NI+DAY+
Sbjct:  144 ELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDS-SKDKFLISRLFDVAEGSTLEEA----SNNCIRLEWNKGIVGHVAAFGEPLNIKDAYE 237
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|B3LVW5|PDE6_DROAN (cGMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila ananassae OX=7217 GN=Pde6 PE=3 SV=1)

HSP 1 Score: 75.485 bits (184), Expect = 7.680e-16
Identity = 52/113 (46.02%), Postives = 70/113 (61.95%), Query Frame = 1 
Query:   10 RSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            R    +LDE E   ELI+D++++LD+  L  KIL NV LL  ADR SLFL +       +YLV+KLFDVT ++ L+D+V +     I I  G GI G VA T +  NI++AYK
Sbjct:  218 RRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAK--GAPNNKYLVAKLFDVTQKTALKDAVTRASTEEIIIPFGIGIAGMVAQTKQMINIKEAYK 328
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|B4HEM4|PDE6_DROSE (cGMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila sechellia OX=7238 GN=Pde6 PE=3 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 9.530e-16
Identity = 53/113 (46.90%), Postives = 70/113 (61.95%), Query Frame = 1 
Query:   10 RSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            R    +LDE E   ELI+D++++LD+  L  KIL NV LL  ADR SLFL +     K  YLV+KLFDVT ++ L+D+V +     I I  G GI G VA T +  NI++AYK
Sbjct:  235 RRHLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNK--YLVAKLFDVTQKTALKDAVARASAEEIIIPFGIGIAGMVAQTKQMINIKEAYK 345
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A0L8G1A2 (GAF domain-containing protein (Fragment) OS=Octopus bimaculoides OX=37653 GN=OCBIM_22002399mg PE=4 SV=1)

HSP 1 Score: 99.3673 bits (246), Expect = 4.212e-23
Identity = 63/116 (54.31%), Postives = 82/116 (70.69%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            RR RS  + LDE E M EL+KD S++LD+T L FKILQNV +LL ADRCSLFL++ +    E+ LVSKLFDV + S  E+ +   ++  IRI+ G GI+G+VA TGE  NI DAY+
Sbjct:  148 RRSRSELQALDEKELMYELVKDTSEELDVTCLCFKILQNVCILLNADRCSLFLVQYN-YAGEKMLVSKLFDVGSNSNYEECLNSMEE--IRIEWGTGIIGYVAKTGEPLNIPDAYQ 260
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A0N8D681 (Phosphodiesterase OS=Daphnia magna OX=35525 GN=APZ42_011297 PE=3 SV=1)

HSP 1 Score: 100.523 bits (249), Expect = 3.869e-22
Identity = 63/116 (54.31%), Postives = 84/116 (72.41%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            RR R+  K+LDE E + EL+KD+ +DLD+ SL  KILQNVS+L +ADRCSLFL++ +   + R LVSKLFDV ++S L++  KK +   IRI  G GI+G+VA +GE  NI DAYK
Sbjct:  287 RRNRNELKSLDEKELIFELVKDICNDLDVRSLCHKILQNVSILTKADRCSLFLVQGERGSESRCLVSKLFDVCSQSTLKEMEKKEE---IRIPWGSGIVGYVAQSGEPVNIPDAYK 399
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A2B4RZX5 (Phosphodiesterase OS=Stylophora pistillata OX=50429 GN=Pde6 PE=3 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 6.573e-22
Identity = 60/114 (52.63%), Postives = 82/114 (71.93%), Query Frame = 1 
Query:    4 RRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            RR+S+F++LDE E   ELI+D++++LD+  L  KIL NVS+L  ADRCSLFL+     +  + LVSKLFDVT+ES +EDS++  +D+ I + +G GI GH A TGE  NI DAY
Sbjct:   96 RRKSSFRDLDEKELFMELIRDIANELDINMLSHKILVNVSILTNADRCSLFLVR--GSRGNKVLVSKLFDVTSESTVEDSIRS-EDDEICVPLGVGIAGHTAATGETININDAY 206
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A210QV80 (Phosphodiesterase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT05839 PE=3 SV=1)

HSP 1 Score: 98.2117 bits (243), Expect = 2.260e-21
Identity = 66/116 (56.90%), Postives = 86/116 (74.14%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            RR RS  K LDE E M EL+ D+ +DLD+TSL  KILQNV +L++ADRCSLFL+   S  +E++LVSKLFDV  E+ LE+ V + +++ IRI  G GI+G+VA TGE +NI DAYK
Sbjct:  130 RRSRSELKALDEKELMYELVIDICNDLDVTSLCHKILQNVCILIDADRCSLFLVH-GSGTEEKHLVSKLFDVNAETSLEE-VSENRES-IRIAWGTGIIGYVAKTGEPQNIPDAYK 242
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A433TZ18 (GAF domain-containing protein OS=Elysia chlorotica OX=188477 GN=EGW08_005471 PE=4 SV=1)

HSP 1 Score: 97.0561 bits (240), Expect = 6.027e-21
Identity = 63/116 (54.31%), Postives = 81/116 (69.83%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            RR +S  K LDE E M EL+ D+ +DLD+TSL +KILQN+ +LL ADRCSLFL++  S K   YL SKLFDVT++S  E      +++ IRI +G GI G+VA TGE  NI DAY+
Sbjct:  427 RRSKSELKALDEKELMYELVIDICNDLDVTSLCYKILQNLCILLNADRCSLFLVKGTSSK---YLASKLFDVTSDSEFETVCD--REDEIRIPLGTGIAGYVAKTGEVVNIPDAYE 537
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde11al (dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like [Source:NCBI gene;Acc:103024879])

HSP 1 Score: 72.7886 bits (177), Expect = 6.041e-16
Identity = 49/106 (46.23%), Postives = 73/106 (68.87%), Query Frame = 1 
Query:   31 DEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            +E EF  EL+KD+S++LD+T+L +KIL NV +++ ADRCSLFL+E  S K  R LVSK FDV + + +  S      + +++  G+GI+G+VA  GE  NI +AY+
Sbjct:  155 NEREFFLELVKDISNELDMTNLSYKILINVCIMVSADRCSLFLVEGPSHK--RTLVSKFFDVHSGTTVRPS-SSMNSSEVQVPWGKGIIGYVAEHGETVNIPNAYE 257
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde11al (dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like [Source:NCBI gene;Acc:103024879])

HSP 1 Score: 72.7886 bits (177), Expect = 7.089e-16
Identity = 49/106 (46.23%), Postives = 73/106 (68.87%), Query Frame = 1 
Query:   31 DEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            +E EF  EL+KD+S++LD+T+L +KIL NV +++ ADRCSLFL+E  S K  R LVSK FDV + + +  S      + +++  G+GI+G+VA  GE  NI +AY+
Sbjct:  155 NEREFFLELVKDISNELDMTNLSYKILINVCIMVSADRCSLFLVEGPSHK--RTLVSKFFDVHSGTTVRPS-SSMNSSEVQVPWGKGIIGYVAEHGETVNIPNAYE 257
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde11a (phosphodiesterase 11a [Source:ZFIN;Acc:ZDB-GENE-070912-207])

HSP 1 Score: 70.8626 bits (172), Expect = 2.910e-15
Identity = 52/110 (47.27%), Postives = 74/110 (67.27%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E EF  EL+KD+S+DLDLTSL +KIL  V ++++ADRCSLFL+E  + KK   LVSK FDV   + +  S+    +  +++  G+GI+G+VA  GE  NI DAY+
Sbjct:  177 LKEHNEREFFLELVKDISNDLDLTSLSYKILVFVCIMVDADRCSLFLVEGTANKKT--LVSKFFDVHAGTTVLPSLSNSDE--VQVPWGKGIIGYVAEHGETVNIPDAYQ 282
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde11a (phosphodiesterase 11a [Source:ZFIN;Acc:ZDB-GENE-070912-207])

HSP 1 Score: 70.8626 bits (172), Expect = 3.054e-15
Identity = 52/110 (47.27%), Postives = 74/110 (67.27%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E EF  EL+KD+S+DLDLTSL +KIL  V ++++ADRCSLFL+E  + KK   LVSK FDV   + +  S+    +  +++  G+GI+G+VA  GE  NI DAY+
Sbjct:  155 LKEHNEREFFLELVKDISNDLDLTSLSYKILVFVCIMVDADRCSLFLVEGTANKKT--LVSKFFDVHAGTTVLPSLSNSDE--VQVPWGKGIIGYVAEHGETVNIPDAYQ 260
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde5ab (cGMP-specific 3',5'-cyclic phosphodiesterase-like [Source:NCBI gene;Acc:103024399])

HSP 1 Score: 63.5438 bits (153), Expect = 1.195e-12
Identity = 46/99 (46.46%), Postives = 69/99 (69.70%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL++D+S  LDLT+L  +I  +   L+ ADR SLFL+ EDS  K ++LVS+LFDV   S LE++     ++ IR++  +GI+GHVA TG+  NI++AY+
Sbjct:  147 ELVRDVSSHLDLTALCHRIFLHTHELIAADRYSLFLVCEDSSNK-KFLVSRLFDVAEGSTLEEA----SNSGIRLEWNKGIVGHVAATGQPLNIKNAYE 240
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: pde5ab (phosphodiesterase 5A, cGMP-specific, b [Source:ZFIN;Acc:ZDB-GENE-060824-4])

HSP 1 Score: 68.1662 bits (165), Expect = 5.216e-15
Identity = 46/105 (43.81%), Postives = 71/105 (67.62%), Query Frame = 1 
Query:   34 EHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            E E   EL+KD++  LD+ +L  +IL +V+ +L ADRCSLF++ EDS  +ER LVS LFDV+    L  + ++ + + +R+  G+GI+G+VA TG   NI +AY+
Sbjct:  102 ERERFLELVKDIACRLDVVTLCHRILLHVNQVLTADRCSLFIVREDS-SQERCLVSTLFDVS----LGSTPEQARTSWLRLAWGKGIVGYVAATGNGVNIPNAYQ 201
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: PDE2A (phosphodiesterase 2A [Source:HGNC Symbol;Acc:HGNC:8777])

HSP 1 Score: 54.299 bits (129), Expect = 4.005e-10
Identity = 35/82 (42.68%), Postives = 48/82 (58.54%), Query Frame = 1 
Query:  103 KILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            +I+Q    L  A+RCS+FL++  S +    LV+K+FD     V+ D   K  +  +RI   QGI GHVA TGE  NI+DAY 
Sbjct:   13 EIIQEARNLSNAERCSVFLLDRSSHE----LVAKVFD---GGVVSDEFMKSYE--VRIPADQGIAGHVATTGEVLNIKDAYS 85
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: PDE2A (phosphodiesterase 2A [Source:HGNC Symbol;Acc:HGNC:8777])

HSP 1 Score: 51.6026 bits (122), Expect = 3.672e-9
Identity = 34/81 (41.98%), Postives = 47/81 (58.02%), Query Frame = 1 
Query:  103 KILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            +I+Q    L  A+RCS+FL++  S +    LV+K+FD     V+ D   +     +RI   QGI GHVA TGE  NI+DAY
Sbjct:   98 EIIQEARNLSNAERCSVFLLDRSSHE----LVAKVFD---GGVVSDESYE-----VRIPADQGIAGHVATTGEVLNIKDAY 166
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: pde10a (phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-040426-1115])

HSP 1 Score: 49.6766 bits (117), Expect = 1.420e-8
Identity = 29/73 (39.73%), Postives = 39/73 (53.42%), Query Frame = 1 
Query:  127 LLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            L+ ADRC+LF ++     K   L S LFD+  E   +   +K K+   R  + +GI G VA TG   NI DAY
Sbjct:  228 LVNADRCALFQVDH----KNNELYSDLFDIGEEKEGQPVFRKTKEITCRFSIEKGIAGQVAKTGMVLNIPDAY 296
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: pde6b (phosphodiesterase 6B, cGMP-specific, rod, beta [Source:ZFIN;Acc:ZDB-GENE-090421-2])

HSP 1 Score: 46.595 bits (109), Expect = 2.009e-7
Identity = 30/94 (31.91%), Postives = 60/94 (63.83%), Query Frame = 1 
Query:   28 LDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVA 309
            ++E E + +L+ ++S+ +++   + K L++++ L++ADRCSLF+  + +   E  L ++LFDVT  S LE+ + + +   I   +  G++GHVA
Sbjct:   54 VEESEILFDLVSNMSETINMEKCMHKCLRHLAGLIDADRCSLFMYRQRNGTPE--LATRLFDVTRTSSLEECLVQPEAE-IVFPLDLGVVGHVA 144
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO39522 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9Q1])

HSP 1 Score: 91.2781 bits (225), Expect = 8.435e-23
Identity = 63/116 (54.31%), Postives = 81/116 (69.83%), Query Frame = 1 
Query:    1 RRRRSAFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            R+ R   + LDE E + EL+KD+S+DLD+ SL  KILQNVS+LL ADRCSLFL +    +  R+LVSK+FDV  ES LED   +C +  IRI  G GI+G+VA TGE  NI +AY+
Sbjct:  107 RKSRLELQQLDEKEVLMELVKDISNDLDVQSLCHKILQNVSILLNADRCSLFLCQGPK-EGPRFLVSKVFDVNAESKLEDV--QCLEE-IRIPWGTGIVGYVAETGETVNIPNAYE 218

HSP 2 Score: 48.9062 bits (115), Expect = 5.422e-8
Identity = 30/83 (36.14%), Postives = 45/83 (54.22%), Query Frame = 1 
Query:   97 VFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            V KI+     LL+ +RCS+ L++  S    + L ++ FD+  +  L++     K   +R  +  GI GHVA TGE  NI DAY
Sbjct:  323 VHKIMMITQSLLQCERCSVLLVDPTS----KTLFAQAFDLEAKDYLQNDDDD-KTVEVRFPINIGITGHVATTGETLNIPDAY 400
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO43657 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RY89])

HSP 1 Score: 78.9518 bits (193), Expect = 1.736e-18
Identity = 53/111 (47.75%), Postives = 76/111 (68.47%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNC--IRIKVGQGIMGHVALTGEHENIEDAY 345
             KN +E EF  E+++D+++DLDL +L +KIL NV +L  ADRCSLFL+E    K +++LVSK+FDV   S+   S K+  D+   IR+ +G G++G+ A TGE  NI DAY
Sbjct:   11 LKNSNEREFFFEIVRDIANDLDLKTLSYKILVNVGILTNADRCSLFLVE--GPKGKQWLVSKVFDVHIGSLNVSSAKEAIDHQREIRVPLGVGLVGYAAETGETVNIPDAY 119
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO31088 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYX3])

HSP 1 Score: 72.7886 bits (177), Expect = 2.106e-16
Identity = 52/106 (49.06%), Postives = 71/106 (66.98%), Query Frame = 1 
Query:   28 LDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            LDE +   ELI+D++++LD+  L  KIL NVS+L  ADR SLFL      K+ R LVSKLFDVT  S +E+S++  +D+ I +  G+GI G  A +GE  NI+DAY
Sbjct:  101 LDEKDKFMELIRDIANELDINRLSHKILVNVSVLTNADRGSLFLTH--GSKENRVLVSKLFDVTTASSVEESIQN-EDDQIVVPFGKGIAGCAAESGEAINIKDAY 203
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO32088 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SW30])

HSP 1 Score: 54.6842 bits (130), Expect = 4.808e-10
Identity = 36/82 (43.90%), Postives = 47/82 (57.32%), Query Frame = 1 
Query:  103 KILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            KI+     L+ ADRCSLFL+++ S +    L + LFD  NE    D   +C  N IR  V +GI G+VA TG   NI DAY+
Sbjct:  146 KIMAFAKKLVNADRCSLFLLDQASEE----LFANLFDDGNE----DGSFRC-GNEIRFPVSKGIAGYVACTGSILNIRDAYR 218
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO44626 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVE3])

HSP 1 Score: 50.447 bits (119), Expect = 1.764e-8
Identity = 31/83 (37.35%), Postives = 45/83 (54.22%), Query Frame = 1 
Query:   97 VFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            + KI+     L++ADR SLFL++     K   L +++FD+     LEDS        IR    +G+ G+VA +GE  NI DAY
Sbjct:  139 IMKIMNYAQTLVDADRTSLFLVD----NKTNELYARIFDIGGS--LEDSRSSQLQKEIRFPKTKGVAGYVATSGETLNISDAY 215
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: ENSORLT00000009688.2 (pep primary_assembly:ASM223467v1:16:16300402:16302109:-1 gene:ENSORLG00000007734.2 transcript:ENSORLT00000009688.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 79.7221 bits (195), Expect = 4.462e-19
Identity = 52/110 (47.27%), Postives = 75/110 (68.18%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E EF  EL+KD+S++LDLT+L +KIL NV +L++ADRCSLFL+E  + K  R LVSK FDV + + +  S      N +++  G+GI+G+VA  GE  NI +AY+
Sbjct:   57 LKETNEREFFLELVKDISNELDLTNLSYKILINVCILVDADRCSLFLVEGPAHK--RTLVSKFFDVHSGTTVRPSSSTVDSNEVQVPWGKGIIGYVAEHGETVNISNAYE 164
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde11a (phosphodiesterase 11A [Source:NCBI gene;Acc:101163533])

HSP 1 Score: 67.781 bits (164), Expect = 4.065e-14
Identity = 52/110 (47.27%), Postives = 73/110 (66.36%), Query Frame = 1 
Query:   19 FKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
             K  +E EF  EL+KD+S+DLDLTSL +KIL  V ++++ADRCSLFL+E    KK   LVSK FDV   + +  S+     + +++  G+GI+G+VA  GE  NI DAY+
Sbjct:  159 LKEHNEREFFLELVKDISNDLDLTSLSYKILVFVCIMVDADRCSLFLVEGTGNKKT--LVSKFFDVHAGTTVLISMNS---DEVQVPWGKGIIGYVAEHGETVNIPDAYQ 263
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde5ab (phosphodiesterase 5A [Source:NCBI gene;Acc:101173207])

HSP 1 Score: 65.855 bits (159), Expect = 1.773e-13
Identity = 47/99 (47.47%), Postives = 68/99 (68.69%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+ +L  KI  +++ L+ ADR SLFL+ EDS  + ++LVS+LFDV   S LE+S        IR++  +GI+GHVA TG+  NI++AYK
Sbjct:  166 ELVKDVSSHLDVPALCHKIFLHINELIAADRYSLFLVGEDSSNR-KFLVSRLFDVAEGSTLEESSSSS----IRLEWNKGIVGHVAATGQPLNIKNAYK 259
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde5ab (phosphodiesterase 5A [Source:NCBI gene;Acc:101173207])

HSP 1 Score: 65.4698 bits (158), Expect = 2.224e-13
Identity = 47/99 (47.47%), Postives = 68/99 (68.69%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+ +L  KI  +++ L+ ADR SLFL+ EDS  + ++LVS+LFDV   S LE+S        IR++  +GI+GHVA TG+  NI++AYK
Sbjct:   98 ELVKDVSSHLDVPALCHKIFLHINELIAADRYSLFLVGEDSSNR-KFLVSRLFDVAEGSTLEESSSSS----IRLEWNKGIVGHVAATGQPLNIKNAYK 191
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde5ab (phosphodiesterase 5A [Source:NCBI gene;Acc:101173207])

HSP 1 Score: 62.7734 bits (151), Expect = 1.965e-12
Identity = 47/99 (47.47%), Postives = 68/99 (68.69%), Query Frame = 1 
Query:   52 ELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            EL+KD+S  LD+ +L  KI  +++ L+ ADR SLFL+ EDS  + ++LVS+LFDV   S LE+S        IR++  +GI+GHVA TG+  NI++AYK
Sbjct:  135 ELVKDVSSHLDVPALCHKIFLHINELIAADRYSLFLVGEDSSNR-KFLVSRLFDVAEGSTLEESSSSS----IRLEWNKGIVGHVAATGQPLNIKNAYK 228
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000019038.1 (SMESG000019038.1)

HSP 1 Score: 198.749 bits (504), Expect = 2.021e-60
Identity = 111/111 (100.00%), Postives = 111/111 (100.00%), Query Frame = 1 
Query:   16 AFKNLDEHEFMKELIKXXXXXXXXXXXVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 348
            AFKNLDEHEFMKELIKDLSDDLDLTSLVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK
Sbjct:  199 AFKNLDEHEFMKELIKDLSDDLDLTSLVFKILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAYK 309
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000021196.1 (SMESG000021196.1)

HSP 1 Score: 55.8398 bits (133), Expect = 4.401e-10
Identity = 36/87 (41.38%), Postives = 49/87 (56.32%), Query Frame = 1 
Query:  106 ILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESV-------LEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            I+Q    L +A+RCS+FL++EDS +    LV+K+FD    S        L+D  +  +   IR    QGI GHVA TGE  NI+ AY
Sbjct:  365 IMQEARNLTQAERCSVFLVDEDSNE----LVAKVFDGLPTSSDKNERLRLQDGTEIQQPVEIRFPKAQGIAGHVATTGEMLNIKKAY 447
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000044149.1 (SMESG000044149.1)

HSP 1 Score: 55.4546 bits (132), Expect = 6.674e-10
Identity = 35/80 (43.75%), Postives = 50/80 (62.50%), Query Frame = 1 
Query:  106 ILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            I+ +   L++A+R SLFL+++DS  KE Y  +K+FD  N S     + + K   IR KVG+G+ G VA TG+  NI DAY
Sbjct:  401 IMASAKSLVKAERVSLFLLDKDS--KELY--AKIFDKGNFST---CIFETKSTMIRFKVGEGVAGKVAETGQTLNIRDAY 473
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000044149.1 (SMESG000044149.1)

HSP 1 Score: 55.4546 bits (132), Expect = 6.748e-10
Identity = 35/80 (43.75%), Postives = 50/80 (62.50%), Query Frame = 1 
Query:  106 ILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            I+ +   L++A+R SLFL+++DS  KE Y  +K+FD  N S     + + K   IR KVG+G+ G VA TG+  NI DAY
Sbjct:  401 IMASAKSLVKAERVSLFLLDKDS--KELY--AKIFDKGNFST---CIFETKSTMIRFKVGEGVAGKVAETGQTLNIRDAY 473
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000021196.1 (SMESG000021196.1)

HSP 1 Score: 55.0694 bits (131), Expect = 7.949e-10
Identity = 35/80 (43.75%), Postives = 47/80 (58.75%), Query Frame = 1 
Query:  106 ILQNVSLLLEADRCSLFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMGHVALTGEHENIEDAY 345
            I+Q    L +A+RCS+FL++EDS +    LV+K+FD     +   S K  +   IR    QGI GHVA TGE  NI+ AY
Sbjct:  365 IMQEARNLTQAERCSVFLVDEDSNE----LVAKVFD----GLPTSSDKNEQPVEIRFPKAQGIAGHVATTGEMLNIKKAY 436
The following BLAST results are available for this feature:
BLAST of Phosphodiesterase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PDE5A1.426e-1648.48phosphodiesterase 5A [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE5A6.875e-1648.48phosphodiesterase 5A [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE5A7.764e-1648.48phosphodiesterase 5A [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE5A8.238e-1648.48phosphodiesterase 5A [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE11A7.104e-1546.36phosphodiesterase 11A [Source:HGNC Symbol;Acc:HGNC... [more]
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BLAST of Phosphodiesterase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pde-52.712e-734.52Probable 3',5'-cyclic phosphodiesterase pde-5 [So... [more]
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BLAST of Phosphodiesterase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pde114.869e-2047.11gene:FBgn0085370 transcript:FBtr0343831[more]
Pde114.869e-2047.11gene:FBgn0085370 transcript:FBtr0112545[more]
Pde115.585e-2047.11gene:FBgn0085370 transcript:FBtr0112544[more]
Pde115.585e-2047.11gene:FBgn0085370 transcript:FBtr0343830[more]
Pde111.047e-1947.11gene:FBgn0085370 transcript:FBtr0303163[more]
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BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde11al2.526e-1745.45phosphodiesterase 11a, like [Source:ZFIN;Acc:ZDB-G... [more]
pde11a2.565e-1547.27phosphodiesterase 11a [Source:ZFIN;Acc:ZDB-GENE-07... [more]
pde11a2.790e-1447.27phosphodiesterase 11a [Source:ZFIN;Acc:ZDB-GENE-07... [more]
pde5ab1.908e-1345.12phosphodiesterase 5A, cGMP-specific, b [Source:ZFI... [more]
pde5ab1.909e-1345.12phosphodiesterase 5A, cGMP-specific, b [Source:ZFI... [more]
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BLAST of Phosphodiesterase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSXETT00000053056.14.619e-1646.36phosphodiesterase 11A [Source:NCBI gene;Acc:100379... [more]
pde5a4.493e-1547.47phosphodiesterase 5A [Source:NCBI gene;Acc:780273][more]
pde5a4.581e-1547.47phosphodiesterase 5A [Source:NCBI gene;Acc:780273][more]
pde5a4.671e-1547.47phosphodiesterase 5A [Source:NCBI gene;Acc:780273][more]
pde5a4.783e-1547.47phosphodiesterase 5A [Source:NCBI gene;Acc:780273][more]
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BLAST of Phosphodiesterase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pde5a6.549e-1749.49phosphodiesterase 5A, cGMP-specific [Source:MGI Sy... [more]
Pde5a6.894e-1749.49phosphodiesterase 5A, cGMP-specific [Source:MGI Sy... [more]
Pde11a6.456e-1446.36phosphodiesterase 11A [Source:MGI Symbol;Acc:MGI:3... [more]
Pde6b1.109e-935.58phosphodiesterase 6B, cGMP, rod receptor, beta pol... [more]
Pde10a9.522e-943.84phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1... [more]
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BLAST of Phosphodiesterase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9VJ79|PDE11_DROME5.599e-1947.11Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 1... [more]
sp|O54735|PDE5A_RAT2.988e-1650.51cGMP-specific 3',5'-cyclic phosphodiesterase OS=Ra... [more]
sp|Q8CG03|PDE5A_MOUSE4.823e-1649.49cGMP-specific 3',5'-cyclic phosphodiesterase OS=Mu... [more]
sp|B3LVW5|PDE6_DROAN7.680e-1646.02cGMP-specific 3',5'-cyclic phosphodiesterase OS=Dr... [more]
sp|B4HEM4|PDE6_DROSE9.530e-1646.90cGMP-specific 3',5'-cyclic phosphodiesterase OS=Dr... [more]
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BLAST of Phosphodiesterase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0L8G1A24.212e-2354.31GAF domain-containing protein (Fragment) OS=Octopu... [more]
A0A0N8D6813.869e-2254.31Phosphodiesterase OS=Daphnia magna OX=35525 GN=APZ... [more]
A0A2B4RZX56.573e-2252.63Phosphodiesterase OS=Stylophora pistillata OX=5042... [more]
A0A210QV802.260e-2156.90Phosphodiesterase OS=Mizuhopecten yessoensis OX=65... [more]
A0A433TZ186.027e-2154.31GAF domain-containing protein OS=Elysia chlorotica... [more]
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BLAST of Phosphodiesterase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde11al6.041e-1646.23dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 1... [more]
pde11al7.089e-1646.23dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 1... [more]
pde11a2.910e-1547.27phosphodiesterase 11a [Source:ZFIN;Acc:ZDB-GENE-07... [more]
pde11a3.054e-1547.27phosphodiesterase 11a [Source:ZFIN;Acc:ZDB-GENE-07... [more]
pde5ab1.195e-1246.46cGMP-specific 3',5'-cyclic phosphodiesterase-like ... [more]
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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde5ab5.216e-1543.81phosphodiesterase 5A, cGMP-specific, b [Source:ZFI... [more]
PDE2A4.005e-1042.68phosphodiesterase 2A [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE2A3.672e-941.98phosphodiesterase 2A [Source:HGNC Symbol;Acc:HGNC:... [more]
pde10a1.420e-839.73phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-04... [more]
pde6b2.009e-731.91phosphodiesterase 6B, cGMP-specific, rod, beta [So... [more]
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BLAST of Phosphodiesterase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO395228.435e-2354.31Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO436571.736e-1847.75Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO310882.106e-1649.06Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO320884.808e-1043.90Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO446261.764e-837.35Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Phosphodiesterase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000009688.24.462e-1947.27pep primary_assembly:ASM223467v1:16:16300402:16302... [more]
pde11a4.065e-1447.27phosphodiesterase 11A [Source:NCBI gene;Acc:101163... [more]
pde5ab1.773e-1347.47phosphodiesterase 5A [Source:NCBI gene;Acc:1011732... [more]
pde5ab2.224e-1347.47phosphodiesterase 5A [Source:NCBI gene;Acc:1011732... [more]
pde5ab1.965e-1247.47phosphodiesterase 5A [Source:NCBI gene;Acc:1011732... [more]
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BLAST of Phosphodiesterase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000019038.12.021e-60100.00SMESG000019038.1[more]
SMESG000021196.14.401e-1041.38SMESG000021196.1[more]
SMESG000044149.16.674e-1043.75SMESG000044149.1[more]
SMESG000044149.16.748e-1043.75SMESG000044149.1[more]
SMESG000021196.17.949e-1043.75SMESG000021196.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30016840 ID=SMED30016840|Name=Phosphodiesterase|organism=Schmidtea mediterranea sexual|type=transcript|length=349bp
CGACGACGAAGAAGTGCTTTCAAAAATCTAGATGAACATGAATTTATGAA
AGAGCTTATTAAAGACTTATCAGACGATTTAGATTTAACTTCGCTTGTTT
TTAAAATTTTGCAAAATGTCAGTTTGTTATTGGAAGCAGATAGGTGTTCG
TTATTTTTAATTGAAGAAGATTCAGTAAAGAAAGAACGTTATTTAGTCAG
CAAGCTTTTCGACGTGACAAATGAAAGCGTTTTAGAAGATAGCGTGAAGA
AATGCAAAGACAATTGTATTAGAATCAAAGTTGGACAAGGAATAATGGGT
CATGTTGCATTGACAGGAGAACATGAAAACATCGAAGATGCATATAAAG
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protein sequence of SMED30016840-orf-1

>SMED30016840-orf-1 ID=SMED30016840-orf-1|Name=SMED30016840-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=116bp
RRRRSAFKNLDEHEFMKELIKDLSDDLDLTSLVFKILQNVSLLLEADRCS
LFLIEEDSVKKERYLVSKLFDVTNESVLEDSVKKCKDNCIRIKVGQGIMG
HVALTGEHENIEDAYK
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000020protonephridia
PLANA:0000099neuron
Vocabulary: INTERPRO
TermDefinition
IPR029016GAF-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081phosphoric diester hydrolase activity
GO:0016787hydrolase activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR029016GAF-like domain superfamilyGENE3DG3DSA:3.30.450.40coord: 8..116
e-value: 1.9E-24
score: 88.1
NoneNo IPR availablePANTHERPTHR11347CYCLIC NUCLEOTIDE PHOSPHODIESTERASEcoord: 4..116
NoneNo IPR availablePANTHERPTHR11347:SF193coord: 4..116
NoneNo IPR availableSUPERFAMILYSSF55781GAF domain-likecoord: 11..115