Cathepsin L

Overview
NameCathepsin L
Smed IDSMED30016824
Length (bp)375
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cathepsin L (SMED30016824) t-SNE clustered cells

Violin plots show distribution of expression levels for Cathepsin L (SMED30016824) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30016824

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30016824SMESG000013980.1 Contig7289newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30016824SMESG000013980.1 Contig7289uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
reproductive organSMED30016824SMESG000013980.1 Contig9364newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016824SMESG000013980.1 Contig9364uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016824SMESG000013980.1 Contig19864newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016824SMESG000013980.1 Contig19864uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016824SMESG000013980.1 Contig7289newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016824SMESG000013980.1 Contig7289uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016824SMESG000013980.1 Contig32941newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016824SMESG000013980.1 Contig32941uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
copulatory apparatusSMED30016824SMESG000020698.1 Contig1344GPL15192PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite colorimetric in situ hybridization evidence
copulatory apparatusSMED30016824SMESG000014171.1 SMESG000013980.1 Contig1344GPL15192PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Cathepsin L vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538])

HSP 1 Score: 140.969 bits (354), Expect = 2.023e-41
Identity = 68/124 (54.84%), Postives = 84/124 (67.74%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y     VAN T FTV+ PG E  L  AVATVGP+SV +DA H  FQ YK+GIY  P CS   L+H VL+VGYG    + N   +W+VKNSWGP+WG  GY+ ++KDK+N CGIA+ A+YP V
Sbjct:  211 CKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
[Close]
BLAST of Cathepsin L vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538])

HSP 1 Score: 140.969 bits (354), Expect = 2.023e-41
Identity = 68/124 (54.84%), Postives = 84/124 (67.74%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y     VAN T FTV+ PG E  L  AVATVGP+SV +DA H  FQ YK+GIY  P CS   L+H VL+VGYG    + N   +W+VKNSWGP+WG  GY+ ++KDK+N CGIA+ A+YP V
Sbjct:  211 CKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
[Close]
BLAST of Cathepsin L vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 127.872 bits (320), Expect = 2.419e-36
Identity = 67/124 (54.03%), Postives = 80/124 (64.52%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG--SLNGDN--FWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y+    VAN T F  I P  E  L  AVATVGP+SV IDA H  F  YK GIY  P CS   ++H VL+VGYG  S   DN  +W+VKNSWG +WG+ GY+ M+KD+ N CGIAS A+YP V
Sbjct:  211 CKYNPKYSVANDTGFVDI-PKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
[Close]
BLAST of Cathepsin L vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 127.872 bits (320), Expect = 2.419e-36
Identity = 67/124 (54.03%), Postives = 80/124 (64.52%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG--SLNGDN--FWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y+    VAN T F  I P  E  L  AVATVGP+SV IDA H  F  YK GIY  P CS   ++H VL+VGYG  S   DN  +W+VKNSWG +WG+ GY+ M+KD+ N CGIAS A+YP V
Sbjct:  211 CKYNPKYSVANDTGFVDI-PKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
[Close]
BLAST of Cathepsin L vs. Ensembl Human
Match: CTSS (cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545])

HSP 1 Score: 126.331 bits (316), Expect = 3.431e-36
Identity = 60/121 (49.59%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC YD     A  + +T +  G E  L  AVA  GPVSV +DA HP F  Y++G+Y  P C+   +NH VL+VGYG LNG  +W+VKNSWG ++G EGYI M+++K N CGIAS  +YP +
Sbjct:  162 KCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCT-QNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI 281
[Close]
BLAST of Cathepsin L vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 120.168 bits (300), Expect = 3.340e-35
Identity = 58/123 (47.15%), Postives = 84/123 (68.29%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGS--LNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC ++K  V A+   +     G+E  L  AVAT GP+S+ IDA H  FQ YK G+Y + +CS   L+H VL+VGYG+   +GD +WIVKNSWG  WG +GYI ++++++N CG+A+ A+YP+V
Sbjct:   77 KCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGD-YWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198
[Close]
BLAST of Cathepsin L vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 120.168 bits (300), Expect = 3.340e-35
Identity = 58/123 (47.15%), Postives = 84/123 (68.29%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGS--LNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC ++K  V A+   +     G+E  L  AVAT GP+S+ IDA H  FQ YK G+Y + +CS   L+H VL+VGYG+   +GD +WIVKNSWG  WG +GYI ++++++N CG+A+ A+YP+V
Sbjct:   77 KCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGD-YWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198
[Close]
BLAST of Cathepsin L vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 121.324 bits (303), Expect = 3.022e-34
Identity = 58/123 (47.15%), Postives = 84/123 (68.29%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGS--LNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC ++K  V A+   +     G+E  L  AVAT GP+S+ IDA H  FQ YK G+Y + +CS   L+H VL+VGYG+   +GD +WIVKNSWG  WG +GYI ++++++N CG+A+ A+YP+V
Sbjct:  216 KCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGD-YWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 337
[Close]
BLAST of Cathepsin L vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597500:1 gene:WBGene00007055.1 transcript:F41E6.6.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196)

HSP 1 Score: 81.6481 bits (200), Expect = 4.397e-19
Identity = 44/116 (37.93%), Postives = 67/116 (57.76%), Query Frame = 1 
Query:   22 KVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPK--CSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            K +A + + +V  P +E ++   + T GP+S+ ++A+    Q Y+ G+ +  K  C    LNH VLIVGYG      +WIVKNSWGP+WG  GY  + + K N CG+  +A   +V
Sbjct:  364 KDIAVYINGSVELPHDEVEMQKWLVTKGPISIGLNAN--TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476
[Close]
BLAST of Cathepsin L vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597469:1 gene:WBGene00007055.1 transcript:F41E6.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196)

HSP 1 Score: 81.6481 bits (200), Expect = 4.397e-19
Identity = 44/116 (37.93%), Postives = 67/116 (57.76%), Query Frame = 1 
Query:   22 KVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPK--CSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            K +A + + +V  P +E ++   + T GP+S+ ++A+    Q Y+ G+ +  K  C    LNH VLIVGYG      +WIVKNSWGP+WG  GY  + + K N CG+  +A   +V
Sbjct:  364 KDIAVYINGSVELPHDEVEMQKWLVTKGPISIGLNAN--TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476
[Close]
BLAST of Cathepsin L vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0304021)

HSP 1 Score: 135.191 bits (339), Expect = 2.632e-40
Identity = 63/121 (52.07%), Postives = 86/121 (71.07%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGS-LNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C ++K  V A    FT I  G+E  +A AVATVGPVSV IDA H  FQ Y  G+YN P+C    L+H VL+VG+G+  +G+++W+VKNSWG  WG +G+I M ++K+NQCGIAS ++YP+V
Sbjct:  129 CHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 249
[Close]
BLAST of Cathepsin L vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087592)

HSP 1 Score: 136.346 bits (342), Expect = 7.271e-40
Identity = 63/121 (52.07%), Postives = 86/121 (71.07%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGS-LNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C ++K  V A    FT I  G+E  +A AVATVGPVSV IDA H  FQ Y  G+YN P+C    L+H VL+VG+G+  +G+++W+VKNSWG  WG +G+I M ++K+NQCGIAS ++YP+V
Sbjct:  221 CHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
[Close]
BLAST of Cathepsin L vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087593)

HSP 1 Score: 136.732 bits (343), Expect = 1.033e-39
Identity = 63/121 (52.07%), Postives = 86/121 (71.07%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGS-LNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C ++K  V A    FT I  G+E  +A AVATVGPVSV IDA H  FQ Y  G+YN P+C    L+H VL+VG+G+  +G+++W+VKNSWG  WG +G+I M ++K+NQCGIAS ++YP+V
Sbjct:  251 CHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 371
[Close]
BLAST of Cathepsin L vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0339955)

HSP 1 Score: 135.961 bits (341), Expect = 1.047e-39
Identity = 63/121 (52.07%), Postives = 86/121 (71.07%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGS-LNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C ++K  V A    FT I  G+E  +A AVATVGPVSV IDA H  FQ Y  G+YN P+C    L+H VL+VG+G+  +G+++W+VKNSWG  WG +G+I M ++K+NQCGIAS ++YP+V
Sbjct:  218 CHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 338
[Close]
BLAST of Cathepsin L vs. Ensembl Fly
Match: CG4847 (gene:FBgn0034229 transcript:FBtr0086934)

HSP 1 Score: 100.138 bits (248), Expect = 8.733e-26
Identity = 52/120 (43.33%), Postives = 71/120 (59.17%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C YD SK  A    F  I P +E  L   VAT+GPV+  ++      ++Y  GIYN+ +C+    NH++L+VGYGS  G ++WIVKNSW   WG +GY  + + K N C IA   +YPVV
Sbjct:  273 CKYDGSKSGATLQGFAAIPPKDEEQLKKVVATLGPVACSVNGLET-LKNYAGGIYNDDECNKGEPNHSILVVGYGSEKGQDYWIVKNSWDDTWGEKGYFRLPRGK-NYCFIAEECSYPVV 390
[Close]
BLAST of Cathepsin L vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61])

HSP 1 Score: 154.451 bits (389), Expect = 8.741e-47
Identity = 71/121 (58.68%), Postives = 91/121 (75.21%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C ++ S V A+ T +  I  G+ES L  AVAT+GP+SV IDA H  FQ Y +G+YN P CS   L+H VL VGYGS NGD++WIVKNSWG DWG++GYILMS++K NQCGIA+ A+YP+V
Sbjct:  214 ECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334
[Close]
BLAST of Cathepsin L vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61])

HSP 1 Score: 154.451 bits (389), Expect = 8.741e-47
Identity = 71/121 (58.68%), Postives = 91/121 (75.21%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C ++ S V A+ T +  I  G+ES L  AVAT+GP+SV IDA H  FQ Y +G+YN P CS   L+H VL VGYGS NGD++WIVKNSWG DWG++GYILMS++K NQCGIA+ A+YP+V
Sbjct:  214 ECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334
[Close]
BLAST of Cathepsin L vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61])

HSP 1 Score: 154.451 bits (389), Expect = 8.741e-47
Identity = 71/121 (58.68%), Postives = 91/121 (75.21%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C ++ S V A+ T +  I  G+ES L  AVAT+GP+SV IDA H  FQ Y +G+YN P CS   L+H VL VGYGS NGD++WIVKNSWG DWG++GYILMS++K NQCGIA+ A+YP+V
Sbjct:  214 ECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334
[Close]
BLAST of Cathepsin L vs. Ensembl Zebrafish
Match: cts12 (cathepsin 12 [Source:ZFIN;Acc:ZDB-GENE-050208-336])

HSP 1 Score: 134.42 bits (337), Expect = 1.214e-39
Identity = 63/120 (52.50%), Postives = 81/120 (67.50%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y+K+  +A  + +  +  GNE  LA AVATVGPVSV IDAD+P F  Y +GIY    C+   LNHAVL+VGYGS  G ++WI+KNSWG  WG  GY+ M ++  N CGIAS A YP++
Sbjct:  162 CFYEKNLAMAGISDYRFVPAGNEQALADAVATVGPVSVAIDADNPSFLFYSSGIYKESNCNPNNLNHAVLVVGYGSEEGTDYWIIKNSWGTGWGEGGYMRMIRNGKNTCGIASYALYPII 281
[Close]
BLAST of Cathepsin L vs. Ensembl Zebrafish
Match: cts12 (cathepsin 12 [Source:ZFIN;Acc:ZDB-GENE-050208-336])

HSP 1 Score: 133.65 bits (335), Expect = 1.619e-39
Identity = 63/120 (52.50%), Postives = 81/120 (67.50%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y+K+  +A  + +  +  GNE  LA AVATVGPVSV IDAD+P F  Y +GIY    C+   LNHAVL+VGYGS  G ++WI+KNSWG  WG  GY+ M ++  N CGIAS A YP++
Sbjct:  145 CFYEKNLAMAGISDYRFVPAGNEQALADAVATVGPVSVAIDADNPSFLFYSSGIYKESNCNPNNLNHAVLVVGYGSEEGTDYWIIKNSWGTGWGEGGYMRMIRNGKNTCGIASYALYPII 264
[Close]
BLAST of Cathepsin L vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 131.724 bits (330), Expect = 6.165e-38
Identity = 65/125 (52.00%), Postives = 84/125 (67.20%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C YD +   AN T F  +  G+E DL  AVA+VGPVSV +DA H  FQ YK+GIY  P+CS   L+H VL+VGYG      +G  +WIVKNSW   WG +GYI ++KD+ N CGIA+ A+YP+V
Sbjct:  211 ECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 335
[Close]
BLAST of Cathepsin L vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 132.109 bits (331), Expect = 6.802e-38
Identity = 65/125 (52.00%), Postives = 84/125 (67.20%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C YD +   AN T F  +  G+E DL  AVA+VGPVSV +DA H  FQ YK+GIY  P+CS   L+H VL+VGYG      +G  +WIVKNSW   WG +GYI ++KD+ N CGIA+ A+YP+V
Sbjct:  218 ECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 342
[Close]
BLAST of Cathepsin L vs. Ensembl Xenopus
Match: mdk (midkine [Source:Xenbase;Acc:XB-GENE-488502])

HSP 1 Score: 130.568 bits (327), Expect = 1.778e-37
Identity = 61/121 (50.41%), Postives = 82/121 (67.77%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C+Y+ +   A+   F  ++ G+E  L  AV  VGPVSV IDA    FQ Y  G+Y +  C+   +NHAVL VGYG+     +WIVKNSWG DWG +GYILM+++KDN CGI+SLA+YPV+
Sbjct:  211 ECMYNATGKAASCKGFKEVQEGSEKALKKAVGLVGPVSVGIDAGLSSFQFYSKGVYYDKDCNAENINHAVLAVGYGTQKKTKYWIVKNSWGEDWGNKGYILMAREKDNACGISSLASYPVM 331
[Close]
BLAST of Cathepsin L vs. Ensembl Xenopus
Match: mdk (midkine [Source:Xenbase;Acc:XB-GENE-488502])

HSP 1 Score: 130.183 bits (326), Expect = 2.909e-37
Identity = 61/121 (50.41%), Postives = 82/121 (67.77%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C+Y+ +   A+   F  ++ G+E  L  AV  VGPVSV IDA    FQ Y  G+Y +  C+   +NHAVL VGYG+     +WIVKNSWG DWG +GYILM+++KDN CGI+SLA+YPV+
Sbjct:  225 ECMYNATGKAASCKGFKEVQEGSEKALKKAVGLVGPVSVGIDAGLSSFQFYSKGVYYDKDCNAENINHAVLAVGYGTQKKTKYWIVKNSWGEDWGNKGYILMAREKDNACGISSLASYPVM 345
[Close]
BLAST of Cathepsin L vs. Ensembl Xenopus
Match: harbi1 (harbinger transposase derived 1 [Source:Xenbase;Acc:XB-GENE-6077433])

HSP 1 Score: 125.176 bits (313), Expect = 2.335e-35
Identity = 61/121 (50.41%), Postives = 78/121 (64.46%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC Y+ S   A    F  ++ G+E+ L  AV  VGP+SV IDA    F  YK GIY +  C    +NHAVL VGYG      +WI+KNSWG DWG +GYILM+++K N CGIA+LA+YPV+
Sbjct:  211 KCKYNVSGRAAEIKGFKEVKKGSETALKKAVGLVGPISVGIDAGLDTFFLYKKGIYYDKSCDGDSINHAVLAVGYGKQKKGKYWIIKNSWGEDWGNKGYILMAREKGNACGIANLASYPVM 331
[Close]
BLAST of Cathepsin L vs. Ensembl Mouse
Match: 4930486L24Rik (RIKEN cDNA 4930486L24 gene [Source:MGI Symbol;Acc:MGI:1922258])

HSP 1 Score: 135.961 bits (341), Expect = 1.091e-39
Identity = 65/125 (52.00%), Postives = 84/125 (67.20%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC Y      AN   F  I PG E  L  AVA VGP+SV +DA H  FQ Y +GIY  P+C  + LNHAVL+VGYG      +G+++W+VKNSWG +WG++GYI ++KD +N CGIA+LA YP+V
Sbjct:  210 KCRYHAENSAANVRDFVQI-PGREEALMKAVAKVGPISVAVDASHDSFQFYDSGIYYEPQCKRVHLNHAVLVVGYGFEGEESDGNSYWLVKNSWGEEWGMKGYIKIAKDWNNHCGIATLATYPIV 333
[Close]
BLAST of Cathepsin L vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 134.035 bits (336), Expect = 7.147e-39
Identity = 66/124 (53.23%), Postives = 82/124 (66.13%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y     VAN T F  I P  E  L  AVATVGP+SV +DA HP  Q Y +GIY  P CS   L+H VL+VGYG      N + +W+VKNSWG +WG+EGYI ++KD+DN CG+A+ A+YPVV
Sbjct:  211 CKYRAEFAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
[Close]
BLAST of Cathepsin L vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 134.035 bits (336), Expect = 7.147e-39
Identity = 66/124 (53.23%), Postives = 82/124 (66.13%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y     VAN T F  I P  E  L  AVATVGP+SV +DA HP  Q Y +GIY  P CS   L+H VL+VGYG      N + +W+VKNSWG +WG+EGYI ++KD+DN CG+A+ A+YPVV
Sbjct:  211 CKYRAEFAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
[Close]
BLAST of Cathepsin L vs. Ensembl Mouse
Match: Ctsll3 (cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917452])

HSP 1 Score: 131.339 bits (329), Expect = 6.879e-38
Identity = 65/121 (53.72%), Postives = 81/121 (66.94%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSL-NGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y+     A  T F  ++  +E  L  AVATVGP+SV ID  H  FQ YK G+Y  P CS   L+HAVL+VGYG   +G  +W+VKNSWG DWG+ GYI M+KD++N CGIAS A+YPVV
Sbjct:  212 CRYNPKNSAATVTGFVNVQ-SSEDALMKAVATVGPISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYGEESDGRKYWLVKNSWGRDWGMNGYIKMAKDRNNNCGIASDASYPVV 331
[Close]
BLAST of Cathepsin L vs. Ensembl Mouse
Match: BC051665 (cDNA sequence BC051665 [Source:MGI Symbol;Acc:MGI:2682300])

HSP 1 Score: 128.642 bits (322), Expect = 7.037e-37
Identity = 64/121 (52.89%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSL-NGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C YD      N T F  + P +E  L  AVA+VGPVSV ID  H  F+ Y+ G Y  P CS   L+HAVL+VGYG   +G  +W+VKNSWG DWG++GYI M+KD+DN CGIA+ A YP V
Sbjct:  211 CRYDPKYSAVNITGFVKV-PLSEDALMNAVASVGPVSVGIDTHHHSFRFYRGGTYYEPDCSSTNLDHAVLVVGYGEESDGRKYWLVKNSWGEDWGMDGYIKMAKDRDNNCGIATYAIYPTV 330
[Close]
BLAST of Cathepsin L vs. UniProt/SwissProt
Match: sp|O60911|CATL2_HUMAN (Cathepsin L2 OS=Homo sapiens OX=9606 GN=CTSV PE=1 SV=2)

HSP 1 Score: 140.969 bits (354), Expect = 9.717e-41
Identity = 68/124 (54.84%), Postives = 84/124 (67.74%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y     VAN T FTV+ PG E  L  AVATVGP+SV +DA H  FQ YK+GIY  P CS   L+H VL+VGYG    + N   +W+VKNSWGP+WG  GY+ ++KDK+N CGIA+ A+YP V
Sbjct:  211 CKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
[Close]
BLAST of Cathepsin L vs. UniProt/SwissProt
Match: sp|P09648|CATL1_CHICK (Cathepsin L1 (Fragments) OS=Gallus gallus OX=9031 GN=CTSL PE=1 SV=1)

HSP 1 Score: 135.191 bits (339), Expect = 9.987e-40
Identity = 66/120 (55.00%), Postives = 79/120 (65.83%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y      AN T F  I  G+E  L  AVA+VGPVSV IDA H  FQ Y++GIY  P CS   L+H VL+VGYG   G  +WIVKNSWG  WG +GYI M+KD+ N CGIA+ A+YP+V
Sbjct:   99 CRYKAEYNAANDTGFVDIPQGHERALMKAVASVGPVSVAIDAGHSSFQFYQSGIYYEPDCSSEDLDHGVLVVGYGFEGGKKYWIVKNSWGEKWGDKGYIYMAKDRKNHCGIATAASYPLV 218
[Close]
BLAST of Cathepsin L vs. UniProt/SwissProt
Match: sp|Q80UB0|TEST2_MOUSE (Testin-2 OS=Mus musculus OX=10090 PE=2 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 7.634e-39
Identity = 65/125 (52.00%), Postives = 84/125 (67.20%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC Y      AN   F  I PG E  L  AVA VGP+SV +DA H  FQ Y +GIY  P+C  + LNHAVL+VGYG      +G+++W+VKNSWG +WG++GYI ++KD +N CGIA+LA YP+V
Sbjct:  210 KCRYHAENSAANVRDFVQI-PGREEALMKAVAKVGPISVAVDASHDSFQFYDSGIYYEPQCKRVHLNHAVLVVGYGFEGEESDGNSYWLVKNSWGEEWGMKGYIKIAKDWNNHCGIATLATYPIV 333
[Close]
BLAST of Cathepsin L vs. UniProt/SwissProt
Match: sp|Q95029|CATL_DROME (Cathepsin L OS=Drosophila melanogaster OX=7227 GN=Cp1 PE=2 SV=2)

HSP 1 Score: 136.732 bits (343), Expect = 1.035e-38
Identity = 63/121 (52.07%), Postives = 86/121 (71.07%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGS-LNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C ++K  V A    FT I  G+E  +A AVATVGPVSV IDA H  FQ Y  G+YN P+C    L+H VL+VG+G+  +G+++W+VKNSWG  WG +G+I M ++K+NQCGIAS ++YP+V
Sbjct:  251 CHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 371
[Close]
BLAST of Cathepsin L vs. UniProt/SwissProt
Match: sp|P06797|CATL1_MOUSE (Cathepsin L1 OS=Mus musculus OX=10090 GN=Ctsl PE=1 SV=2)

HSP 1 Score: 134.035 bits (336), Expect = 4.999e-38
Identity = 66/124 (53.23%), Postives = 82/124 (66.13%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y     VAN T F  I P  E  L  AVATVGP+SV +DA HP  Q Y +GIY  P CS   L+H VL+VGYG      N + +W+VKNSWG +WG+EGYI ++KD+DN CG+A+ A+YPVV
Sbjct:  211 CKYRAEFAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
[Close]
BLAST of Cathepsin L vs. TrEMBL
Match: A0A0N9WMD3 (Cathepsin L OS=Cerebratulus lacteus OX=6221 PE=2 SV=1)

HSP 1 Score: 159.844 bits (403), Expect = 1.101e-45
Identity = 69/121 (57.02%), Postives = 92/121 (76.03%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C + KS V A  T F  ++ G+E  L +AV+ VGPVSV IDA HP FQ Y++G+YN P+CS   L+H VL+VGYGS NG ++W+VKNSWGP WGI GYI MS++++NQCGIA+ A+YP+V
Sbjct:  209 RCRFQKSCVAATVTGFVDVQRGSEDALKSAVSEVGPVSVAIDAGHPSFQGYRSGVYNEPRCSQTALDHGVLVVGYGSENGQDYWLVKNSWGPSWGINGYIKMSRNRNNQCGIATQASYPLV 329
[Close]
BLAST of Cathepsin L vs. TrEMBL
Match: A0A1I8IYR5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 160.229 bits (404), Expect = 1.636e-45
Identity = 71/121 (58.68%), Postives = 90/121 (74.38%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C Y +S+V AN T F  I  G+E  L  AVA VGPVSV IDA HP FQHY++G+YN P CS   L+H VL+VGYG+L+G ++W+VKNSW   WG +GYI MS++K+NQCGIAS A+YP V
Sbjct:  231 RCQYQRSRVAANCTGFVDIPQGSEDKLKEAVANVGPVSVAIDASHPSFQHYQSGVYNEPACSSQQLDHGVLVVGYGTLSGSDYWLVKNSWSDMWGEKGYIRMSRNKNNQCGIASTASYPTV 351
[Close]
BLAST of Cathepsin L vs. TrEMBL
Match: A0A1I8IU52 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 160.614 bits (405), Expect = 1.818e-45
Identity = 71/121 (58.68%), Postives = 90/121 (74.38%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C Y +S+V AN T F  I  G+E  L  AVA VGPVSV IDA HP FQHY++G+YN P CS   L+H VL+VGYG+L+G ++W+VKNSW   WG +GYI MS++K+NQCGIAS A+YP V
Sbjct:  253 RCQYQRSRVAANCTGFVDIPQGSEDKLKEAVANVGPVSVAIDASHPSFQHYQSGVYNEPACSSQQLDHGVLVVGYGTLSGSDYWLVKNSWSDMWGEKGYIRMSRNKNNQCGIASTASYPTV 373
[Close]
BLAST of Cathepsin L vs. TrEMBL
Match: A0A267GB11 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008319g1 PE=3 SV=1)

HSP 1 Score: 160.229 bits (404), Expect = 1.915e-45
Identity = 71/121 (58.68%), Postives = 90/121 (74.38%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C Y +S+V AN T F  I  G+E  L  AVA VGPVSV IDA HP FQHY++G+YN P CS   L+H VL+VGYG+L+G ++W+VKNSW   WG +GYI MS++K+NQCGIAS A+YP V
Sbjct:  242 RCQYQRSRVAANCTGFVDIPQGSEDKLKEAVANVGPVSVAIDASHPSFQHYQSGVYNEPACSSQQLDHGVLVVGYGTLSGSDYWLVKNSWSDMWGEKGYIRMSRNKNNQCGIASTASYPTV 362
[Close]
BLAST of Cathepsin L vs. TrEMBL
Match: A0A267DZX3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig002369g2 PE=3 SV=1)

HSP 1 Score: 160.229 bits (404), Expect = 1.915e-45
Identity = 71/121 (58.68%), Postives = 90/121 (74.38%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C Y +S+V AN T F  I  G+E  L  AVA VGPVSV IDA HP FQHY++G+YN P CS   L+H VL+VGYG+L+G ++W+VKNSW   WG +GYI MS++K+NQCGIAS A+YP V
Sbjct:  242 RCQYQRSRVAANCTGFVDIPQGSEDKLKEAVANVGPVSVAIDASHPSFQHYQSGVYNEPACSSQQLDHGVLVVGYGTLSGSDYWLVKNSWSDMWGEKGYIRMSRNKNNQCGIASTASYPTV 362
[Close]
BLAST of Cathepsin L vs. Ensembl Cavefish
Match: ctsl.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023607])

HSP 1 Score: 144.05 bits (362), Expect = 8.248e-43
Identity = 66/120 (55.00%), Postives = 86/120 (71.67%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C +    V A  T F  I  G+E  L  AVAT+GP+SV IDA H  FQ Y++GIYN P CS   L+H VL VGYG+ NG ++W+VKNSWG DWG +GYI MS+++DNQCGIA++++YP+V
Sbjct:  214 CRFKPDSVGATCTGFVDITSGDEKALQEAVATIGPISVAIDAGHSSFQLYESGIYNEPDCSSTELDHGVLAVGYGTDNGKDYWLVKNSWGLDWGNKGYIQMSRNEDNQCGIATMSSYPLV 333
[Close]
BLAST of Cathepsin L vs. Ensembl Cavefish
Match: ENSAMXT00000034444.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000030.1:64026:71815:-1 gene:ENSAMXG00000001761.2 transcript:ENSAMXT00000034444.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 142.895 bits (359), Expect = 1.441e-42
Identity = 67/120 (55.83%), Postives = 85/120 (70.83%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C +    V A  T F  I  G+E  L  AVAT+GP+SV IDA H  FQ Y++GIYN P CS   L+H VL VGYG+ +G ++W+VKNSWG DWG +GYI MS++KDNQCGIA+ A+YP+V
Sbjct:  196 CRFKPDSVGATCTGFVDITSGDEKALQEAVATIGPISVAIDAGHSSFQLYESGIYNEPDCSSSDLDHGVLAVGYGTDSGKDYWLVKNSWGLDWGNKGYIQMSRNKDNQCGIATAASYPLV 315
[Close]
BLAST of Cathepsin L vs. Ensembl Cavefish
Match: ENSAMXT00000001797.2 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000030.1:64026:71812:-1 gene:ENSAMXG00000001761.2 transcript:ENSAMXT00000001797.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 142.124 bits (357), Expect = 1.813e-42
Identity = 67/120 (55.83%), Postives = 85/120 (70.83%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C +    V A  T F  I  G+E  L  AVAT+GP+SV IDA H  FQ Y++GIYN P CS   L+H VL VGYG+ +G ++W+VKNSWG DWG +GYI MS++KDNQCGIA+ A+YP+V
Sbjct:  186 CRFKPDSVGATCTGFVDITSGDEKALQEAVATIGPISVAIDAGHSSFQLYESGIYNEPDCSSSDLDHGVLAVGYGTDSGKDYWLVKNSWGLDWGNKGYIQMSRNKDNQCGIATAASYPLV 305
[Close]
BLAST of Cathepsin L vs. Ensembl Cavefish
Match: ENSAMXT00000042132.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924])

HSP 1 Score: 133.65 bits (335), Expect = 8.078e-39
Identity = 65/120 (54.17%), Postives = 82/120 (68.33%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y    V A  + +  I  G+E  L  AVATVGPVSV ID  H  FQ Y++G+Y+ P CS   L HAVL VGYGS  G ++W+VKNSWG  WG +GYI MS++K+NQCGIA+ A+YP+V
Sbjct:  213 CRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYGSDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYPLV 332
[Close]
BLAST of Cathepsin L vs. Ensembl Cavefish
Match: ENSAMXT00000048039.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924])

HSP 1 Score: 133.65 bits (335), Expect = 8.078e-39
Identity = 65/120 (54.17%), Postives = 82/120 (68.33%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y    V A  + +  I  G+E  L  AVATVGPVSV ID  H  FQ Y++G+Y+ P CS   L HAVL VGYGS  G ++W+VKNSWG  WG +GYI MS++K+NQCGIA+ A+YP+V
Sbjct:  213 CRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYGSDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYPLV 332
[Close]
BLAST of Cathepsin L vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007755.1 (pep scaffold:Pmarinus_7.0:GL476381:1843:17023:-1 gene:ENSPMAG00000007008.1 transcript:ENSPMAT00000007755.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 139.043 bits (349), Expect = 1.067e-41
Identity = 63/122 (51.64%), Postives = 89/122 (72.95%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPG-NESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC +  + V    +S+  +EP  NE  L  AVA+VGP+++ ++AD   F+HYK+G++N P C     NHA+L+VGYGSL+G++FWIVKNSWG DWG +GYI M ++KDNQCGIAS+  YP++
Sbjct:  213 KCRFKPANVATKCSSYQFVEPSSNEEVLRQAVASVGPIAIAMNADLDTFKHYKSGLFNEPSCD-KSPNHAMLVVGYGSLSGNDFWIVKNSWGEDWGEKGYIYMIRNKDNQCGIASIGIYPII 333
[Close]
BLAST of Cathepsin L vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006499.1 (pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 gene:ENSPMAG00000005817.1 transcript:ENSPMAT00000006499.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 136.346 bits (342), Expect = 1.575e-40
Identity = 67/125 (53.60%), Postives = 83/125 (66.40%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG----SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC YD     AN T F  +  G+E  L  AVA+VGPVSV IDA H  FQ Y++G+Y  P CS   L+H VL+VGYG      NG  +WIVKNSW P WG EGY+LM+++K N CGIA+ A+YP+V
Sbjct:  215 KCHYDPKFNSANDTGFVDVTSGDEKALKIAVASVGPVSVAIDASHESFQFYQSGVYFEPDCSSQDLDHGVLVVGYGVKGTGENGKKYWIVKNSWSPKWGDEGYVLMARNKKNHCGIATAASYPLV 339
[Close]
BLAST of Cathepsin L vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011285.1 (pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gene:ENSPMAG00000010258.1 transcript:ENSPMAT00000011285.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 123.635 bits (309), Expect = 5.636e-36
Identity = 65/121 (53.72%), Postives = 80/121 (66.12%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDN-FWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y+     A  T F  I  GNE  L  AVA+VGPVS+ IDA    FQ Y +GIY++  CS   L+H VL+VGYG  + +  FWIVKNSWG  WG  GYILM++DKDN CGIA+ A+YP+V
Sbjct:  178 CKYNPKNKAAEDTGFVDIPSGNEEALKNAVASVGPVSIGIDASLESFQLYSSGIYSDSDCSN-NLDHGVLVVGYGVDDDERKFWIVKNSWGTKWGDHGYILMARDKDNLCGIATAASYPLV 297
[Close]
BLAST of Cathepsin L vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010475.1 (pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 gene:ENSPMAG00000009483.1 transcript:ENSPMAT00000010475.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 120.553 bits (301), Expect = 7.995e-35
Identity = 60/121 (49.59%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG-SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C YD     A  T +  I  G+E  L  AVA+VGPVSV IDA    FQ Y +GIY +  CS   ++HAVL+VGYG    G  FW+VKNSWG  WG +GY+ M++D +N CGIA++++YP+V
Sbjct:  174 CKYDPKNKAAEVTGYVEIPEGDEEALMNAVASVGPVSVAIDASLASFQSYGSGIYKDAMCSHH-IDHAVLVVGYGVDEMGQKFWLVKNSWGVTWGEQGYVRMARDDNNLCGIATMSSYPLV 293
[Close]
BLAST of Cathepsin L vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003800.1 (pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 gene:ENSPMAG00000003453.1 transcript:ENSPMAT00000003800.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 119.013 bits (297), Expect = 2.586e-34
Identity = 61/121 (50.41%), Postives = 79/121 (65.29%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYG-SLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y+     A  T +  I  G+E  L  AVA+VGPVSV IDA    F +Y +GIY +  CS + +NHAVL+VGYG    GD FW+VKNSWG  WG +GY+ M++D +N CGIA  A+YP+V
Sbjct:  176 CKYNPKNKAAEVTGYVEIPEGDEEALKNAVASVGPVSVAIDASLNSFLYYISGIYKDKLCSHI-INHAVLVVGYGVDEKGDKFWLVKNSWGVQWGEKGYVRMARDDNNLCGIAVTASYPLV 295
[Close]
BLAST of Cathepsin L vs. Ensembl Nematostella
Match: EDO46465 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPY5])

HSP 1 Score: 149.058 bits (375), Expect = 2.255e-45
Identity = 67/121 (55.37%), Postives = 89/121 (73.55%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C +    V A  T +T ++ G+E DL +AVATVGP+SV IDA H  FQ YKTG+Y+ P CS   L+H VL VGYG+ +G ++W+VKNSWG  WG+ GYI MS++KDNQCGIA+ A+YP+V
Sbjct:  205 QCHFKPGSVGATVTGYTDVQRGSEGDLQSAVATVGPISVAIDAGHSSFQLYKTGVYSEPDCSSTQLDHGVLAVGYGAEDGKDYWLVKNSWGEGWGMNGYIKMSRNKDNQCGIATQASYPLV 325
[Close]
BLAST of Cathepsin L vs. Ensembl Nematostella
Match: EDO36727 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHX1])

HSP 1 Score: 145.591 bits (366), Expect = 6.763e-44
Identity = 63/121 (52.07%), Postives = 86/121 (71.07%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C + KS + A  T F  +  G+E  L  A  TVGP+SV IDA H  FQ Y +G+YNN  CS   L+H VL+VGYG+  G ++W+VKNSWG  WG+EGYI+MS++K+NQCG+A+ A+YP+V
Sbjct:  210 RCRFQKSNIGAVDTGFVDVTHGDEEALKTAAGTVGPISVAIDAGHMSFQFYHSGVYNNAGCSSTSLDHGVLVVGYGTYQGSDYWLVKNSWGERWGMEGYIMMSRNKNNQCGVATQASYPLV 330
[Close]
BLAST of Cathepsin L vs. Ensembl Nematostella
Match: EDO45953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRH6])

HSP 1 Score: 140.969 bits (354), Expect = 3.099e-42
Identity = 65/120 (54.17%), Postives = 88/120 (73.33%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C +  S V A  T +  I  G+E  L +AVATVGPVSV +DA    +Q Y +G+Y+NP CS   L+H VL++GYG+ NG ++W+VKNSWG  WG+EGYI+MS++K+NQCGIAS A+YP+V
Sbjct:  209 CHFSSSHVGARVTGYQDIPQGSEQALQSAVATVGPVSVAVDASQ--WQFYSSGVYDNPYCSSTQLDHGVLVIGYGNYNGQDYWLVKNSWGYSWGVEGYIMMSRNKNNQCGIASSASYPLV 326
[Close]
BLAST of Cathepsin L vs. Ensembl Nematostella
Match: EDO45852 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL9])

HSP 1 Score: 129.798 bits (325), Expect = 8.966e-38
Identity = 58/120 (48.33%), Postives = 84/120 (70.00%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C Y+KS + A  T F  I  G+E+ L  A+A+VGP+S+ IDA    F  Y  G+Y++P CS   L+H VL VGYG+ +G ++W+VKNSWGP WG EGYI ++++  ++CG+AS A+YP+V
Sbjct:  212 CHYNKSAIGAKDTGFVDIPTGDENALQQALASVGPISIAIDASQSTFHFYHQGVYDDPDCSSTRLDHGVLAVGYGTDDGKDYWLVKNSWGPSWGEEGYIKIARNDHDKCGVASKASYPLV 331
[Close]
BLAST of Cathepsin L vs. Ensembl Nematostella
Match: EDO41322 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4P4])

HSP 1 Score: 109.383 bits (272), Expect = 4.401e-29
Identity = 52/119 (43.70%), Postives = 73/119 (61.34%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLC--LNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAY 354
            C    +++ A  T +  I  G+ S L  A+A  GP+SV IDA H     Y  G+Y  PKC      L+H+VL VGYG+++G  +W++KNSW   WG+ GY+LMS+ KDN CG+A+ A Y
Sbjct:  427 CHKKDAEIGATITGYVNITEGDLSALKTAIAQKGPISVSIDASHKSLSFYSYGVYYEPKCGNKNEDLDHSVLAVGYGTMDGKPYWMIKNSWSTHWGMNGYVLMSQ-KDNNCGVATAATY 544
[Close]
BLAST of Cathepsin L vs. Ensembl Medaka
Match: ctsl.1 (cathepsin L1 [Source:NCBI gene;Acc:101171789])

HSP 1 Score: 139.813 bits (351), Expect = 3.596e-41
Identity = 65/121 (53.72%), Postives = 85/121 (70.25%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            +C Y    V A  T +  +  G+E  L  AVAT+GP+SV IDA H  FQ Y++G+Y+ P+CS   L+H VL VGYGS NG ++W+VKNSWG  WG +GYI MSK+K NQCGIA+ A+YP+V
Sbjct:  219 ECRYKPDAVGATCTGYVDVSSGDEDALQEAVATIGPISVGIDASHISFQLYESGLYDEPQCSSSELDHGVLAVGYGSENGQDYWLVKNSWGLTWGDQGYIKMSKNKSNQCGIATAASYPLV 339
[Close]
BLAST of Cathepsin L vs. Ensembl Medaka
Match: cts12 (cathepsin L1-like [Source:NCBI gene;Acc:101170830])

HSP 1 Score: 131.724 bits (330), Expect = 3.234e-38
Identity = 60/120 (50.00%), Postives = 79/120 (65.83%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C YD    VA+   +  I  G+E  LA AVAT+GP++V IDADH  F  Y +GIY+ P C    L+HAVL+VGYGS  G ++WI+KNSWG  WG  GY+ + ++  N CGIAS A YP++
Sbjct:  199 CFYDSRLAVAHIKDYRFIPQGDEQALADAVATIGPITVAIDADHASFLFYSSGIYDEPNCDPNRLSHAVLLVGYGSEEGQDYWIIKNSWGSSWGEGGYMRIIRNGSNTCGIASYALYPIL 318
[Close]
BLAST of Cathepsin L vs. Ensembl Medaka
Match: cts12 (cathepsin L1-like [Source:NCBI gene;Acc:101170830])

HSP 1 Score: 131.724 bits (330), Expect = 3.391e-38
Identity = 60/120 (50.00%), Postives = 79/120 (65.83%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C YD    VA+   +  I  G+E  LA AVAT+GP++V IDADH  F  Y +GIY+ P C    L+HAVL+VGYGS  G ++WI+KNSWG  WG  GY+ + ++  N CGIAS A YP++
Sbjct:  213 CFYDSRLAVAHIKDYRFIPQGDEQALADAVATIGPITVAIDADHASFLFYSSGIYDEPNCDPNRLSHAVLLVGYGSEEGQDYWIIKNSWGSSWGEGGYMRIIRNGSNTCGIASYALYPIL 332
[Close]
BLAST of Cathepsin L vs. Ensembl Medaka
Match: cts12 (cathepsin L1-like [Source:NCBI gene;Acc:101170830])

HSP 1 Score: 131.724 bits (330), Expect = 3.447e-38
Identity = 60/120 (50.00%), Postives = 79/120 (65.83%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C YD    VA+   +  I  G+E  LA AVAT+GP++V IDADH  F  Y +GIY+ P C    L+HAVL+VGYGS  G ++WI+KNSWG  WG  GY+ + ++  N CGIAS A YP++
Sbjct:  202 CFYDSRLAVAHIKDYRFIPQGDEQALADAVATIGPITVAIDADHASFLFYSSGIYDEPNCDPNRLSHAVLLVGYGSEEGQDYWIIKNSWGSSWGEGGYMRIIRNGSNTCGIASYALYPIL 321
[Close]
BLAST of Cathepsin L vs. Ensembl Medaka
Match: cts12 (cathepsin L1-like [Source:NCBI gene;Acc:101170830])

HSP 1 Score: 131.339 bits (329), Expect = 3.561e-38
Identity = 60/120 (50.00%), Postives = 79/120 (65.83%), Query Frame = 1 
Query:    4 CIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            C YD    VA+   +  I  G+E  LA AVAT+GP++V IDADH  F  Y +GIY+ P C    L+HAVL+VGYGS  G ++WI+KNSWG  WG  GY+ + ++  N CGIAS A YP++
Sbjct:  199 CFYDSRLAVAHIKDYRFIPQGDEQALADAVATIGPITVAIDADHASFLFYSSGIYDEPNCDPNRLSHAVLLVGYGSEEGQDYWIIKNSWGSSWGEGGYMRIIRNGSNTCGIASYALYPIL 318
[Close]
BLAST of Cathepsin L vs. Planmine SMEST
Match: SMESG000013980.1 (SMESG000013980.1)

HSP 1 Score: 252.677 bits (644), Expect = 4.151e-84
Identity = 120/121 (99.17%), Postives = 120/121 (99.17%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KCIYDKSK VANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV
Sbjct:  323 KCIYDKSKAVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 443
[Close]
BLAST of Cathepsin L vs. Planmine SMEST
Match: SMESG000014171.1 (SMESG000014171.1)

HSP 1 Score: 216.083 bits (549), Expect = 4.363e-71
Identity = 101/121 (83.47%), Postives = 110/121 (90.91%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KCIYDKSKVVANFTS+T  +PGNESDLAAAVATVGP+S+ IDADHPGFQHYK GIYNNP CS   L+HAVL+VGYGSLNG+N+WIVKNSWGP WGIEGYILMSKDKDNQCGIA+ A YPVV
Sbjct:  213 KCIYDKSKVVANFTSYTFTKPGNESDLAAAVATVGPLSIGIDADHPGFQHYKNGIYNNPTCSSEYLDHAVLVVGYGSLNGNNYWIVKNSWGPHWGIEGYILMSKDKDNQCGIATQAVYPVV 333
[Close]
BLAST of Cathepsin L vs. Planmine SMEST
Match: SMESG000014016.1 (SMESG000014016.1)

HSP 1 Score: 185.267 bits (469), Expect = 1.225e-59
Identity = 92/121 (76.03%), Postives = 100/121 (82.64%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KCIYDKSKVVANFTS+T  +  NESDLAAAVATVGP+SV IDA     Q+YK GIYNNP CS   L H VL+VGYGSLNGDN+WIVKNSWG D+GI GYILMSKDKDNQCGIA+ A YPVV
Sbjct:  165 KCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPMSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 285
[Close]
BLAST of Cathepsin L vs. Planmine SMEST
Match: SMESG000013992.1 (SMESG000013992.1)

HSP 1 Score: 186.037 bits (471), Expect = 2.401e-59
Identity = 92/121 (76.03%), Postives = 100/121 (82.64%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KCIYDKSKVVANFTS+T  +  NESDLAAAVATVGP+SV IDA     Q+YK GIYNNP CS   L H VL+VGYGSLNGDN+WIVKNSWG D+GI GYILMSKDKDNQCGIA+ A YPVV
Sbjct:  213 KCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 333
[Close]
BLAST of Cathepsin L vs. Planmine SMEST
Match: SMESG000014167.1 (SMESG000014167.1)

HSP 1 Score: 164.851 bits (416), Expect = 3.811e-51
Identity = 79/121 (65.29%), Postives = 94/121 (77.69%), Query Frame = 1 
Query:    1 KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 363
            KC YD+SKVV   + FT I+ GNESDLA AVATVGPVSV IDA H  FQ YK GIYN P+CS   L+H VL VGYGS NG N+W+VKNSWG  WG+ GYI MSKD++NQCGI++ A++P+V
Sbjct:  213 KCKYDRSKVVGTCSGFTDIKHGNESDLAVAVATVGPVSVAIDASHYSFQLYKGGIYNEPQCSPDQLDHGVLAVGYGSENGGNYWLVKNSWGISWGLSGYIKMSKDRNNQCGISTSASFPLV 333
The following BLAST results are available for this feature:
BLAST of Cathepsin L vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CTSV2.023e-4154.84cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538][more]
CTSV2.023e-4154.84cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538][more]
CTSL2.419e-3654.03cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSL2.419e-3654.03cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSS3.431e-3649.59cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545][more]
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BLAST of Cathepsin L vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cpl-13.340e-3547.15CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-13.340e-3547.15CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-13.022e-3447.15CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
tag-1964.397e-1937.93pep chromosome:WBcel235:V:8594914:8597500:1 gene:W... [more]
tag-1964.397e-1937.93pep chromosome:WBcel235:V:8594914:8597469:1 gene:W... [more]
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BLAST of Cathepsin L vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cp12.632e-4052.07gene:FBgn0013770 transcript:FBtr0304021[more]
Cp17.271e-4052.07gene:FBgn0013770 transcript:FBtr0087592[more]
Cp11.033e-3952.07gene:FBgn0013770 transcript:FBtr0087593[more]
Cp11.047e-3952.07gene:FBgn0013770 transcript:FBtr0339955[more]
CG48478.733e-2643.33gene:FBgn0034229 transcript:FBtr0086934[more]
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BLAST of Cathepsin L vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl.18.741e-4758.68cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61][more]
ctsl.18.741e-4758.68cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61][more]
ctsl.18.741e-4758.68cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61][more]
cts121.214e-3952.50cathepsin 12 [Source:ZFIN;Acc:ZDB-GENE-050208-336][more]
cts121.619e-3952.50cathepsin 12 [Source:ZFIN;Acc:ZDB-GENE-050208-336][more]
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BLAST of Cathepsin L vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fcrl26.165e-3852.00Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
fcrl26.802e-3852.00Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
mdk1.778e-3750.41midkine [Source:Xenbase;Acc:XB-GENE-488502][more]
mdk2.909e-3750.41midkine [Source:Xenbase;Acc:XB-GENE-488502][more]
harbi12.335e-3550.41harbinger transposase derived 1 [Source:Xenbase;Ac... [more]
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BLAST of Cathepsin L vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
4930486L24Rik1.091e-3952.00RIKEN cDNA 4930486L24 gene [Source:MGI Symbol;Acc:... [more]
Ctsl7.147e-3953.23cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
Ctsl7.147e-3953.23cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
Ctsll36.879e-3853.72cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917... [more]
BC0516657.037e-3752.89cDNA sequence BC051665 [Source:MGI Symbol;Acc:MGI:... [more]
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BLAST of Cathepsin L vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O60911|CATL2_HUMAN9.717e-4154.84Cathepsin L2 OS=Homo sapiens OX=9606 GN=CTSV PE=1 ... [more]
sp|P09648|CATL1_CHICK9.987e-4055.00Cathepsin L1 (Fragments) OS=Gallus gallus OX=9031 ... [more]
sp|Q80UB0|TEST2_MOUSE7.634e-3952.00Testin-2 OS=Mus musculus OX=10090 PE=2 SV=1[more]
sp|Q95029|CATL_DROME1.035e-3852.07Cathepsin L OS=Drosophila melanogaster OX=7227 GN=... [more]
sp|P06797|CATL1_MOUSE4.999e-3853.23Cathepsin L1 OS=Mus musculus OX=10090 GN=Ctsl PE=1... [more]
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BLAST of Cathepsin L vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0N9WMD31.101e-4557.02Cathepsin L OS=Cerebratulus lacteus OX=6221 PE=2 S... [more]
A0A1I8IYR51.636e-4558.68Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8IU521.818e-4558.68Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267GB111.915e-4558.68Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267DZX31.915e-4558.68Uncharacterized protein OS=Macrostomum lignano OX=... [more]
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BLAST of Cathepsin L vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl.18.248e-4355.00cathepsin L1-like [Source:NCBI gene;Acc:103023607][more]
ENSAMXT00000034444.11.441e-4255.83pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000001797.21.813e-4255.83pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000042132.18.078e-3954.17cathepsin L1-like [Source:NCBI gene;Acc:103023924][more]
ENSAMXT00000048039.18.078e-3954.17cathepsin L1-like [Source:NCBI gene;Acc:103023924][more]
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BLAST of Cathepsin L vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000007755.11.067e-4151.64pep scaffold:Pmarinus_7.0:GL476381:1843:17023:-1 g... [more]
ENSPMAT00000006499.11.575e-4053.60pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 g... [more]
ENSPMAT00000011285.15.636e-3653.72pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gen... [more]
ENSPMAT00000010475.17.995e-3549.59pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 ... [more]
ENSPMAT00000003800.12.586e-3450.41pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 g... [more]
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BLAST of Cathepsin L vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cathepsin L vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO464652.255e-4555.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO367276.763e-4452.07Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO459533.099e-4254.17Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458528.966e-3848.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO413224.401e-2943.70Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cathepsin L vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl.13.596e-4153.72cathepsin L1 [Source:NCBI gene;Acc:101171789][more]
cts123.234e-3850.00cathepsin L1-like [Source:NCBI gene;Acc:101170830][more]
cts123.391e-3850.00cathepsin L1-like [Source:NCBI gene;Acc:101170830][more]
cts123.447e-3850.00cathepsin L1-like [Source:NCBI gene;Acc:101170830][more]
cts123.561e-3850.00cathepsin L1-like [Source:NCBI gene;Acc:101170830][more]
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BLAST of Cathepsin L vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000013980.14.151e-8499.17SMESG000013980.1[more]
SMESG000014171.14.363e-7183.47SMESG000014171.1[more]
SMESG000014016.11.225e-5976.03SMESG000014016.1[more]
SMESG000013992.12.401e-5976.03SMESG000013992.1[more]
SMESG000014167.13.811e-5165.29SMESG000014167.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30016824 ID=SMED30016824|Name=Cathepsin L|organism=Schmidtea mediterranea sexual|type=transcript|length=375bp
AAATGTATTTATGATAAATCAAAAGTTGTTGCAAATTTCACTTCGTTTAC
TGTTATCGAGCCAGGAAACGAATCTGACTTGGCAGCCGCCGTGGCCACCG
TTGGACCTGTGTCCGTATGCATCGATGCCGATCATCCAGGTTTCCAACAT
TATAAAACTGGTATTTACAATAACCCCAAATGTTCATTTTTATGCTTAAA
TCATGCCGTTTTAATCGTTGGTTATGGATCACTCAATGGAGATAACTTTT
GGATTGTGAAGAACAGTTGGGGACCAGATTGGGGAATAGAAGGATACATA
CTCATGTCAAAGGACAAGGACAACCAATGTGGAATTGCTAGTCTAGCCGC
TTATCCAGTGGTCTAATATGCATGC
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protein sequence of SMED30016824-orf-1

>SMED30016824-orf-1 ID=SMED30016824-orf-1|Name=SMED30016824-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=122bp
KCIYDKSKVVANFTSFTVIEPGNESDLAAAVATVGPVSVCIDADHPGFQH
YKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYI
LMSKDKDNQCGIASLAAYPVV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000070intestinal phagocyte
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR039417Peptidase_C1A_papain-like
IPR038765Papain-like_cys_pep_sf
IPR000668Peptidase_C1A_C
IPR025661Pept_asp_AS
IPR025660Pept_his_AS
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
Vocabulary: molecular function
TermDefinition
GO:0008234cysteine-type peptidase activity
GO:0008233peptidase activity
GO:0016787hydrolase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000668Peptidase C1A, papain C-terminalSMARTSM00645pept_c1coord: 1..120
e-value: 1.8E-8
score: 24.4
IPR000668Peptidase C1A, papain C-terminalPFAMPF00112Peptidase_C1coord: 1..119
e-value: 3.9E-37
score: 128.4
NoneNo IPR availableGENE3DG3DSA:3.90.70.10coord: 1..121
e-value: 3.1E-42
score: 147.3
NoneNo IPR availablePANTHERPTHR12411CYSTEINE PROTEASE FAMILY C1-RELATEDcoord: 2..120
NoneNo IPR availablePANTHERPTHR12411:SF57CATHEPSIN L2coord: 2..120
IPR025660Cysteine peptidase, histidine active sitePROSITEPS00639THIOL_PROTEASE_HIScoord: 66..76
IPR025661Cysteine peptidase, asparagine active sitePROSITEPS00640THIOL_PROTEASE_ASNcoord: 83..102
IPR039417Papain-like cysteine endopeptidaseCDDcd02248Peptidase_C1Acoord: 1..119
e-value: 5.16427E-54
score: 166.26
IPR038765Papain-like cysteine peptidase superfamilySUPERFAMILYSSF54001Cysteine proteinasescoord: 1..121