C2H2-type domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30016687 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: D7GXL4 (Rho_N domain-containing protein OS=Tribolium castaneum OX=7070 GN=TcasGA2_TC006914 PE=4 SV=1) HSP 1 Score: 79.337 bits (194), Expect = 1.218e-13 Identity = 42/129 (32.56%), Postives = 76/129 (58.91%), Query Frame = 2 Query: 32 KIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSYNPTVI 418 + + + GSGWT+ I + + KY+ L+G+ ++E P +K K+A +N+KN+DN CF+YSI++ L +R N Y+ ++NELN++ I + P+++ +I +FE N + + V SY + Sbjct: 306 RCDELQEKGSGWTLKNINHLRININKYTP---LSGNSYVELPKWIKDKKACVNVKNNDNKCFMYSIISCLHQAKEHVDRLNHYNKPEYINELNFEGI-NFPVKIQDIPKFESHN-KINVTVFSYEEQIF 429
BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: A0A2B4RKZ6 (Uncharacterized transposon-derived protein F54H12.3 OS=Stylophora pistillata OX=50429 GN=F54H12.3 PE=4 SV=1) HSP 1 Score: 78.9518 bits (193), Expect = 1.814e-13 Identity = 50/133 (37.59%), Postives = 69/133 (51.88%), Query Frame = 2 Query: 8 EGVRKLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSYN 406 E V K+ E + FT+ GSGWT+ + + KY+ L G +I P L K+AIIN+KN D+ CF + I L R + L LN+D I D PM L +I RFE NPGL +NV +++ Sbjct: 727 ECVEKMMESLATFTRNGSGWTVDSVDGLDLHTVKYTP---LKGSSYIPLPQHLANKKAIINMKNKDDKCFKWRIARALNPVEKDQERVSKILIKQALR-LNFDGI-DFPMELKSIGRFERLNPGLGVNVYTWS 854
BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: A0A4Y2I7M8 (Uncharacterized protein (Fragment) OS=Araneus ventricosus OX=182803 GN=AVEN_191623_1 PE=4 SV=1) HSP 1 Score: 75.0998 bits (183), Expect = 5.093e-13 Identity = 50/131 (38.17%), Postives = 67/131 (51.15%), Query Frame = 2 Query: 11 GVRKLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSY 403 G K+ E F GSGW I I + Y + L FI P A+ KRAIINIKN+DN CF++ +LA L H N + + +Y F+ LN D+I P L I RFE+ N ++INV + Sbjct: 87 GFVKIQTSCEEFQTRGSGWVIDAILYLEVNTCTY---HPLAASSFIPLPSAIAKKRAIINIKNTDNKCFLWCVLAAL-HPATTNPQ-RVSNYLPFVKSLNLDKITF-PTPLSQIDRFEKLN-NISINVFGF 210
BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: A0A2B4RAD9 (Uncharacterized protein OS=Stylophora pistillata OX=50429 GN=AWC38_SpisGene21206 PE=4 SV=1) HSP 1 Score: 77.411 bits (189), Expect = 6.003e-13 Identity = 52/146 (35.62%), Postives = 74/146 (50.68%), Query Frame = 2 Query: 8 EGVRKLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSY----NPTVINNDEN 433 E V K+ E + FT+ GSGWT++ + + KY+ L G FI P L K+AIIN+KN D CF++ + L R + L L +D I + PM + +ISRFE NPGL +NV Y NP ++ +N Sbjct: 328 ECVDKMMESLATFTRNGSGWTVNSVDGLDLHTVKYTP---LKGSSFIPLPQHLANKKAIINMKNGDQQCFMWCVTRALNPVERDQERISKTLRKQALR-LKFDGI-NFPMEVKDISRFERLNPGLGVNVYMYEGGLNPLRVSEAQN 468
BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: A0A2B4SJP5 (Uncharacterized protein OS=Stylophora pistillata OX=50429 GN=AWC38_SpisGene5933 PE=4 SV=1) HSP 1 Score: 77.411 bits (189), Expect = 6.036e-13 Identity = 41/128 (32.03%), Postives = 75/128 (58.59%), Query Frame = 2 Query: 20 KLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSY 403 +L +++ FTQL SGW + R + + KY+ G+ +++ ++ K+AIIN+KN D+ CF ++ L+ L + R N +Y F ELN+ + PM++ NIS+FE++NP ++++ + Y Sbjct: 256 RLEDQMSNFTQLASGWVLERNNNVALQMVKYAPRK---GNSYLQLHPSIADKKAIINVKNKDDHCFKWATLSALHPMEIHPERVN--NYIPFEEELNFSGL-TLPMKINNISQFEKQNPSISVSFIGY 377
BLAST of C2H2-type domain-containing protein vs. Ensembl Nematostella
Match: EDO44110 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RWZ0]) HSP 1 Score: 58.5362 bits (140), Expect = 1.869e-10 Identity = 40/128 (31.25%), Postives = 63/128 (49.22%), Query Frame = 2 Query: 35 IERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKN-SDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSYNPTV 415 +E+F + GSGW R ++ + L+G +I P L K+AIIN+KN SD+ CF +++ + + R N T N+ I + P+ L I FE++NP A+NV Y +V Sbjct: 9 VEKFQKQGSGW---RFDQVEYFDINIDPXKPLSGSSYIPLPSELASKKAIINVKNESDHECFKWAVTSAIYPKETHPERLNK-QMTESSKNFNWSGI-EFPISLKQIDEFEKQNPH-AVNVYGYEGSV 130
BLAST of C2H2-type domain-containing protein vs. Ensembl Nematostella
Match: EDO48021 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKP4]) HSP 1 Score: 56.6102 bits (135), Expect = 9.625e-10 Identity = 42/137 (30.66%), Postives = 67/137 (48.91%), Query Frame = 2 Query: 23 LNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNS-DNLCFIYSILALL----KHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSYNPTVI 418 L E IERF GSGW R ++ + L+G +I+ P L K+AIIN+KN D+ CF +++ + + K +N + S + ++ I + P+ L I +FE++NP +NV YN V Sbjct: 201 LLELIERFQNKGSGW---RFDQVEYFDINIDPFEPLSGSSYIQLPSKLASKQAIINVKNKNDHECFKWAVTSAMYPRGKDPQRLNEQIRESS-----KKFDWAGI-EFPVSLKQIDKFEKQNP-YTVNVFGYNGEVF 327
BLAST of C2H2-type domain-containing protein vs. Ensembl Nematostella
Match: EDO46109 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR56]) HSP 1 Score: 54.299 bits (129), Expect = 7.767e-9 Identity = 36/128 (28.12%), Postives = 64/128 (50.00%), Query Frame = 2 Query: 35 IERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNS-DNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEID----DCPMRLCNISRFEEKNPGLAINVLSY 403 +E+F + GSGW R+ + + + L+G ++E P L K+AIIN++N D+ CF +++ + + R N + + E N + D + P+ L I +FE +NP +NV +Y Sbjct: 585 VEKFQKQGSGWQFDRVEYFDINIDPF---DPLSGSSYVELPKELAVKKAIINVRNENDHKCFKWAVTS-----AVYPKRDNPQRLSRKMME-NSERFDWSGIEFPVSLRQIDKFERQNPH-TVNVFTY 702
BLAST of C2H2-type domain-containing protein vs. Ensembl Nematostella
Match: EDO34977 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMS5]) HSP 1 Score: 53.9138 bits (128), Expect = 9.888e-9 Identity = 36/128 (28.12%), Postives = 64/128 (50.00%), Query Frame = 2 Query: 35 IERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNS-DNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEID----DCPMRLCNISRFEEKNPGLAINVLSY 403 +E+F + GSGW R+ + + + L+G ++E P L K+AIIN++N D+ CF +++ + + R N + + E N + D + P+ L I +FE +NP +NV +Y Sbjct: 158 VEKFQKQGSGWQFDRVEYFDINIDPF---DPLSGSSYVELPKELAVKKAIINVRNENDHKCFKWAVTS-----AVYPKRDNPQRLSRKMME-NSERFDWSGIEFPVSLRQIDKFERQNPH-TVNVFTY 275
BLAST of C2H2-type domain-containing protein vs. Ensembl Nematostella
Match: EDO34080 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQD5]) HSP 1 Score: 52.7582 bits (125), Expect = 2.217e-8 Identity = 38/128 (29.69%), Postives = 61/128 (47.66%), Query Frame = 2 Query: 35 IERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNS-DNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSYNPTV 415 +E+F + GSGW R ++ + L+G +I L K+AIIN+KN D+ CF +++ + + R N T N+ I + P+ L I FE++NP A+NV Y +V Sbjct: 362 VEKFQKQGSGW---RFDQVEYFDINIDPFKPLSGSSYIPLLSELASKKAIINVKNENDHECFKWAVTSAIYPKETHPERLNK-QMTESSKNFNWSGI-EFPISLKQIDEFEKQNPH-AVNVYGYEGSV 483
BLAST of C2H2-type domain-containing protein vs. Planmine SMEST
Match: SMESG000007603.1 (SMESG000007603.1) HSP 1 Score: 275.789 bits (704), Expect = 1.161e-86 Identity = 135/145 (93.10%), Postives = 137/145 (94.48%), Query Frame = 2 Query: 2 LVEGVRKLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSYNPTVINNDENE 436 L EGVRKLNEKIERFTQLGSGWTISRIREIHFI TKY Q+NRLT HG IETP+ALKGK AIINIKNSDNLCFIYSILALLKHDVLVNNRS MYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNP LAINVLSYNPTVINNDENE Sbjct: 184 LDEGVRKLNEKIERFTQLGSGWTISRIREIHFIFTKYFQINRLTDHGLIETPLALKGKIAIINIKNSDNLCFIYSILALLKHDVLVNNRSKMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPCLAINVLSYNPTVINNDENE 328
BLAST of C2H2-type domain-containing protein vs. Planmine SMEST
Match: SMESG000060519.1 (SMESG000060519.1) HSP 1 Score: 262.692 bits (670), Expect = 5.566e-82 Identity = 130/145 (89.66%), Postives = 136/145 (93.79%), Query Frame = 2 Query: 2 LVEGVRKLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSYNPTVINNDENE 436 LVEGVRKLNEKIERFTQL S WTISRIREIHFIL KYSQ+NRLTGH FIETP+ LKGK AIINIKNS+NLCFIYSILALLKHDVL NNRSNMYSYTNFLN LNY+EIDDCPMRLCNISRFEE+NPGLAINVLS NPTVINNDEN+ Sbjct: 339 LVEGVRKLNEKIERFTQLCSEWTISRIREIHFILNKYSQINRLTGHRFIETPLNLKGKGAIINIKNSENLCFIYSILALLKHDVLGNNRSNMYSYTNFLNGLNYEEIDDCPMRLCNISRFEERNPGLAINVLSCNPTVINNDENK 483
BLAST of C2H2-type domain-containing protein vs. Planmine SMEST
Match: SMESG000035558.1 (SMESG000035558.1) HSP 1 Score: 223.787 bits (569), Expect = 2.103e-67 Identity = 115/144 (79.86%), Postives = 120/144 (83.33%), Query Frame = 2 Query: 5 VEGVRKLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNPGLAINVLSYNPTVINNDENE 436 VEGVRKLNEKIERFTQLGSGWTISRI+EIHFILTKYSQ+NRLT HGFIET + LKGKRAIINIKNSDNLC IYSILALLKHDVLVNNR +DC MRLCNIS FEEKNPGLAINVLSYNPTVINNDEN+ Sbjct: 986 VEGVRKLNEKIERFTQLGSGWTISRIKEIHFILTKYSQINRLTNHGFIETTLNLKGKRAIINIKNSDNLCVIYSILALLKHDVLVNNR------------------NDCLMRLCNISMFEEKNPGLAINVLSYNPTVINNDENK 1111
BLAST of C2H2-type domain-containing protein vs. Planmine SMEST
Match: SMESG000054673.1 (SMESG000054673.1) HSP 1 Score: 199.904 bits (507), Expect = 8.008e-61 Identity = 102/118 (86.44%), Postives = 105/118 (88.98%), Query Frame = 2 Query: 2 LVEGVRKLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNIS 355 VEGVRKLNEKIERFTQ GSGWTISRI EIHFILTKYSQ+NRLTGHGFIET + LKGKRAIINIKNSDNLCFIYSILAL KHDVLVNNR YTNF NELNY EI+DCPMRLCNIS Sbjct: 35 FVEGVRKLNEKIERFTQFGSGWTISRILEIHFILTKYSQINRLTGHGFIETLLVLKGKRAIINIKNSDNLCFIYSILALSKHDVLVNNR-----YTNFQNELNY-EINDCPMRLCNIS 146
BLAST of C2H2-type domain-containing protein vs. Planmine SMEST
Match: SMESG000023611.1 (SMESG000023611.1) HSP 1 Score: 181.03 bits (458), Expect = 1.427e-52 Identity = 91/141 (64.54%), Postives = 108/141 (76.60%), Query Frame = 2 Query: 2 LVEGVRKLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIETPIALKGKRAIINIKNSDNLCFIYSILALLKHDVLVNNRSNMYSYTNFLNELNYDEIDDCPMRLCNISRFEEKNP--GLAINVLSYNPTVI 418 L EGV KLNEKIE+FT LGSGW I I EIHFILTKY+ +NRL+GH +I+TP ALK K AI+NIKN+D+ CF+YSIL LLK D++ N + YT FL+EL YDEI DCPM+L NI +FE+KN LAINV SY PTVI Sbjct: 772 LSEGVNKLNEKIEQFTHLGSGWRIINIMEIHFILTKYAPINRLSGHKYIKTPSALKNKGAIVNIKNNDDKCFLYSILYLLKKDIIGENPQRVSKYTEFLDELEYDEITDCPMKLINIPKFEKKNSTLKLAINVFSYTPTVI 912 The following BLAST results are available for this feature:
BLAST of C2H2-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of C2H2-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of C2H2-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of C2H2-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30016687 ID=SMED30016687|Name=C2H2-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=597bpback to top protein sequence of SMED30016687-orf-1 >SMED30016687-orf-1 ID=SMED30016687-orf-1|Name=SMED30016687-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=163bp LVEGVRKLNEKIERFTQLGSGWTISRIREIHFILTKYSQMNRLTGHGFIEback to top Annotated Terms
The following terms have been associated with this transcript:
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