NK homeobox6-2

Overview


Name	NK homeobox6-2
Smed ID	SMED30016686
Length (bp)	960

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of NK homeobox6-2 (SMED30016686) t-SNE clustered cells

Violin plots show distribution of expression levels for NK homeobox6-2 (SMED30016686) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of NK homeobox6-2 (SMED30016686) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for NK homeobox6-2 (SMED30016686) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30016686

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
body wall musculature	SMED30016686	h1SMcG0022072	dd_Smed_v4_12873_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of NK homeobox6-2 vs. Ensembl Human
Match: NKX6-1 (NK6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7839])

HSP 1 Score: 137.117 bits (344), Expect = 5.356e-37
Identity = 63/95 (66.32%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            C+  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+ATA++    E + ++ 
Sbjct:  221 CTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKG 315

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Human
Match: NKX6-2 (NK6 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:19321])

HSP 1 Score: 133.265 bits (334), Expect = 2.620e-36
Identity = 74/167 (44.31%), Postives = 93/167 (55.69%), Query Frame = 1

Query:  253 FKTPHGIMDILSR--------------------------------IENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSP------INDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARR 639
              TPHGI DIL R                                +    P+  + L   +PP+  P      + +   D R++ P      ++   ++KH+RPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR A E+A+A++
Sbjct:   54 LGTPHGISDILGRPVGAAGGGLLGGLPRLNGLASSAGVYFGPAAAVARGYPKPLAEL-PGRPPIFWP---GVVQGAPWRDPRLAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKK 216

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BLAST of NK homeobox6-2 vs. Ensembl Human
Match: NKX6-3 (NK6 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:26328])

HSP 1 Score: 126.716 bits (317), Expect = 5.761e-34
Identity = 75/157 (47.77%), Postives = 92/157 (58.60%), Query Frame = 1

Query:  259 TPHGIMDILSR-IENPKPEFYS------------TLNTAKPPLINPIKKSKSE------------------NSNCSDTRISSPINDS-NRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATA 633
            TPHGI DILSR +  P     S            +      P +    K+ +E                     CS+T    P++DS +++KHTRPTF+G QIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+SA E +++
Sbjct:   51 TPHGITDILSRPVAAPNNSLLSGYPHVAGFGGLSSQGVYYSPQVGNFSKAGNEYPTRTRNCWADTGQDWRGGRQCSNT--PDPLSDSIHKKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALEPSSS 205

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Human
Match: TLX2 (T cell leukemia homeobox 2 [Source:HGNC Symbol;Acc:HGNC:5057])

HSP 1 Score: 78.5666 bits (192), Expect = 4.279e-16
Identity = 42/92 (45.65%), Postives = 57/92 (61.96%), Query Frame = 1

Query:  400 RISSPINDSN--RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQ 669
            RI  P  +    +RK  R +FS  Q+  LE++F + KYLA  ER  LA  L M+++QVK WFQNRRTKWR+++A E    R  AG  + H+Q
Sbjct:  144 RIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQ 235

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Human
Match: TLX3 (T cell leukemia homeobox 3 [Source:HGNC Symbol;Acc:HGNC:13532])

HSP 1 Score: 75.0998 bits (183), Expect = 8.281e-15
Identity = 39/81 (48.15%), Postives = 53/81 (65.43%), Query Frame = 1

Query:  430 RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            +RK  R +FS  QI  LEK+F + KYLA  ER  LA  L M+++QVK WFQNRRTKWR+++A E    R+ A   +  +Q+
Sbjct:  165 KRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQH 245

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BLAST of NK homeobox6-2 vs. Ensembl Celegans
Match: cog-1 (COG-1B [Source:UniProtKB/TrEMBL;Acc:G5EGF2])

HSP 1 Score: 105.145 bits (261), Expect = 4.987e-28
Identity = 50/79 (63.29%), Postives = 63/79 (79.75%), Query Frame = 1

Query:  409 SPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNA 645
            SP + + ++K +RPTF+G QI+ LE+KFEQTKYLAG +R +LA  L MSESQVKVWFQNRRTKWRK+ AA+ A  +R A
Sbjct:   11 SPNSLNMQKKQSRPTFTGHQIYQLERKFEQTKYLAGADRAQLAQELNMSESQVKVWFQNRRTKWRKKEAADNALVKRGA 89

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Celegans
Match: cog-1 (COG-1B [Source:UniProtKB/TrEMBL;Acc:G5EGF2])

HSP 1 Score: 106.301 bits (264), Expect = 7.900e-27
Identity = 50/79 (63.29%), Postives = 63/79 (79.75%), Query Frame = 1

Query:  409 SPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNA 645
            SP + + ++K +RPTF+G QI+ LE+KFEQTKYLAG +R +LA  L MSESQVKVWFQNRRTKWRK+ AA+ A  +R A
Sbjct:  161 SPNSLNMQKKQSRPTFTGHQIYQLERKFEQTKYLAGADRAQLAQELNMSESQVKVWFQNRRTKWRKKEAADNALVKRGA 239

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BLAST of NK homeobox6-2 vs. Ensembl Celegans
Match: ceh-9 (Homeobox protein ceh-9 [Source:UniProtKB/Swiss-Prot;Acc:P56407])

HSP 1 Score: 82.8037 bits (203), Expect = 3.972e-19
Identity = 53/124 (42.74%), Postives = 71/124 (57.26%), Query Frame = 1

Query:  250 QFKTPHGIMDILS--RIENPKPEF---YSTLNTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRK 606
            Q +T H I DIL    +     EF    S+L+ AK    +PI+K       C  T+          RK  R TFSG+Q+F LEK+FE  KYL+  +R+ LA  L ++E+QVK+WFQNRRTKW+K
Sbjct:   24 QRRTSHLIKDILDLPTVNGEIDEFGRCKSSLDQAKE---SPIEK-------CQKTK----------RKKARTTFSGKQVFELEKQFEAKKYLSSSDRSELAKRLDVTETQVKIWFQNRRTKWKK 127

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Celegans
Match: ceh-1 (Homeobox protein ceh-1 [Source:UniProtKB/Swiss-Prot;Acc:P53547])

HSP 1 Score: 68.9366 bits (167), Expect = 7.643e-14
Identity = 31/66 (46.97%), Postives = 46/66 (69.70%), Query Frame = 1

Query:  430 RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIA 627
            + +  R  F+ +Q+ ALE KF+ ++YL+  ER  LA  L +SE+QVK+WFQNRRTKW+K +  + A
Sbjct:   39 KMRRARTAFTYEQLVALENKFKTSRYLSVVERLNLAIQLQLSETQVKIWFQNRRTKWKKHNPGQDA 104

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BLAST of NK homeobox6-2 vs. Ensembl Celegans
Match: tab-1 (pep chromosome:WBcel235:II:6803758:6804863:1 gene:WBGene00006380.1 transcript:F31E8.3a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tab-1)

HSP 1 Score: 68.5514 bits (166), Expect = 1.779e-13
Identity = 40/100 (40.00%), Postives = 53/100 (53.00%), Query Frame = 1

Query:  307 PEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRK 606
            P F+ST +  +  L N  K  +     CS             R+  R  FS QQ+  LE++FE  +YL+ PER  LA  L +SE+QVK WFQNRR K +K
Sbjct:   93 PGFWSTADQIR--LSNATKAYRRLRLECS-------------RRKARTVFSDQQLQGLERRFESQRYLSTPERIELANALNLSETQVKTWFQNRRMKHKK 177

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Fly
Match: HGTX (gene:FBgn0040318 transcript:FBtr0075720)

HSP 1 Score: 142.124 bits (357), Expect = 4.849e-38
Identity = 70/103 (67.96%), Postives = 82/103 (79.61%), Query Frame = 1

Query:  346 LINPI----KKSKSENSNCSDTRISSPINDSN-RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARR 639
            + NPI    + S + ++N S +    P ND + ++KHTRPTFSGQQIFALEK FEQTKYLAGPER +LAY LGMSESQVKVWFQNRRTKWRKR AAE+ATA+R
Sbjct:  358 VANPIAWRERLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKR 460

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Fly
Match: NK7.1 (gene:FBgn0024321 transcript:FBtr0306742)

HSP 1 Score: 88.5817 bits (218), Expect = 4.680e-19
Identity = 38/63 (60.32%), Postives = 50/63 (79.37%), Query Frame = 1

Query:  421 DSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKR 609
            D+ R+K  R TF+G+QIF LEK FE  KYL+  ERT +A LL ++E+QVK+WFQNRRTKW+K+
Sbjct:  389 DARRKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKWKKQ 451

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Fly
Match: NK7.1 (gene:FBgn0024321 transcript:FBtr0347151)

HSP 1 Score: 88.5817 bits (218), Expect = 4.680e-19
Identity = 38/63 (60.32%), Postives = 50/63 (79.37%), Query Frame = 1

Query:  421 DSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKR 609
            D+ R+K  R TF+G+QIF LEK FE  KYL+  ERT +A LL ++E+QVK+WFQNRRTKW+K+
Sbjct:  389 DARRKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKWKKQ 451

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Fly
Match: NK7.1 (gene:FBgn0024321 transcript:FBtr0082942)

HSP 1 Score: 88.5817 bits (218), Expect = 4.680e-19
Identity = 38/63 (60.32%), Postives = 50/63 (79.37%), Query Frame = 1

Query:  421 DSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKR 609
            D+ R+K  R TF+G+QIF LEK FE  KYL+  ERT +A LL ++E+QVK+WFQNRRTKW+K+
Sbjct:  389 DARRKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKWKKQ 451

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Fly
Match: NK7.1 (gene:FBgn0024321 transcript:FBtr0082941)

HSP 1 Score: 88.5817 bits (218), Expect = 4.680e-19
Identity = 38/63 (60.32%), Postives = 50/63 (79.37%), Query Frame = 1

Query:  421 DSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKR 609
            D+ R+K  R TF+G+QIF LEK FE  KYL+  ERT +A LL ++E+QVK+WFQNRRTKW+K+
Sbjct:  389 DARRKKKARTTFTGRQIFELEKMFENKKYLSASERTEMAKLLMVTETQVKIWFQNRRTKWKKQ 451

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Zebrafish
Match: nkx6.1 (NK6 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-040718-178])

HSP 1 Score: 137.502 bits (345), Expect = 7.756e-38
Identity = 64/95 (67.37%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            CS  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR AAE+A+A++    E + ++ 
Sbjct:  171 CSPHQNSVLLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKKKQDSETERLKG 265

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Zebrafish
Match: nkx6.2 (NK6 homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-070626-1])

HSP 1 Score: 135.191 bits (339), Expect = 2.728e-37
Identity = 78/170 (45.88%), Postives = 95/170 (55.88%), Query Frame = 1

Query:  253 FKTPHGIMDILSRIENPKPEFYST------LNTAKPPLINPIKKSK-------------------SENSNCSDTRISSP------INDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQ 669
              TPHGI DIL R      +  S       L T+     NP   S+                    + S   D R+         ++   ++KH+RPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR AAE+ATA++    E + ++
Sbjct:   60 LGTPHGISDILGRPITTAGQLLSGFPRINGLATSAGMYFNPAAVSRYPKPLTELPGRAPIFWPGMMQGSPWRDPRVPCAAQANMMLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMATAKKKHDSETEKMK 229

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Zebrafish
Match: nkx6.3 (NK6 homeobox 3 [Source:ZFIN;Acc:ZDB-GENE-070810-7])

HSP 1 Score: 127.487 bits (319), Expect = 2.140e-34
Identity = 80/176 (45.45%), Postives = 94/176 (53.41%), Query Frame = 1

Query:  250 QFKTPHGIMDILSR----------------------IENPKPEFY-------STLNTAKPPLINPIK-KSKSENS-------------NCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAG 648
            Q  TPHGI DILSR                         P P  Y       S L+T   P++     K KS +               C +    +P N   ++KHTRPTFSG QIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+SA E ++ + + G
Sbjct:   48 QAGTPHGISDILSRSMVSGPGTPALLSGYPSMGGFGTTVPSPGVYYNRDYTPSGLSTFPKPVVECAGMKGKSSSCWVDGGYEWRGARQQCGNNMGHNPEN-VGKKKHTRPTFSGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSATEPSSTQTSRG 222

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Zebrafish
Match: nkx6.3 (NK6 homeobox 3 [Source:ZFIN;Acc:ZDB-GENE-070810-7])

HSP 1 Score: 121.324 bits (303), Expect = 8.091e-34
Identity = 56/74 (75.68%), Postives = 64/74 (86.49%), Query Frame = 1

Query:  427 NRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAG 648
             ++KHTRPTFSG QIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+SA E ++ + + G
Sbjct:    3 GKKKHTRPTFSGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSATEPSSTQTSRG 76

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Zebrafish
Match: hmx3b (H6 family homeobox 3b [Source:ZFIN;Acc:ZDB-GENE-130603-102])

HSP 1 Score: 78.9518 bits (193), Expect = 5.103e-17
Identity = 38/86 (44.19%), Postives = 56/86 (65.12%), Query Frame = 1

Query:  376 ENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATA 633
            E+S+C + R    +    R+K TR  FS  Q+F LE  F+  +YL+  ER  LA  L ++E+QVK+WFQNRR KW+++ AAE+ +A
Sbjct:   83 EDSDCEEARAQ--VKKLCRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQIAAELESA 166

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Xenopus
Match: zfand1 (zinc finger AN1-type containing 1 [Source:Xenbase;Acc:XB-GENE-1217582])

HSP 1 Score: 136.346 bits (342), Expect = 1.441e-37
Identity = 79/174 (45.40%), Postives = 98/174 (56.32%), Query Frame = 1

Query:  253 FKTPHGIMDILSRIENPKPEFYSTLNTAKPPL----------INPIKKSK-------------------SENSNCSDTRISSP------INDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQ 669
              TPHGI DILSR         + L ++ P +           NP   S+                    + S   D R+  P      ++   ++KH+RPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR AAE+ATA++    E + ++
Sbjct:   59 LGTPHGISDILSRPLGATLGSSANLLSSLPRINGLATSTGMYFNPAAVSRYPKPLAELPGRAPIFWPGVMQGSPWRDPRLGCPSQAGMVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMATAKKKHDSETEKMK 232

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Xenopus
Match: meis1 (Meis homeobox 1 [Source:Xenbase;Acc:XB-GENE-479439])

HSP 1 Score: 137.502 bits (345), Expect = 2.696e-37
Identity = 63/95 (66.32%), Postives = 75/95 (78.95%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            C   + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+ATA++    E + ++ 
Sbjct:  206 CGPHQGSVLLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDTETERLKG 300

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Xenopus
Match: znf608 (zinc finger protein 608 [Source:Xenbase;Acc:XB-GENE-491957])

HSP 1 Score: 125.176 bits (313), Expect = 1.866e-33
Identity = 79/153 (51.63%), Postives = 92/153 (60.13%), Query Frame = 1

Query:  259 TPHGIMDILSRIENPKPEFYSTLNTAKPPL----------------INPIKKSKSENSNCS---------DTR-----ISSPIN--DSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAE 621
            TPHGI DILSR   P P  +S +    P +                 + + KS +  +N S         D R     +SS  N   S+R+KHTRPTF+G QIFALEK FEQTKYLAGPER RLA+ LGMSESQVKVWFQNRRTKWRK+SA E
Sbjct:   47 TPHGISDILSR---PLPASHSGMFPGYPTVQGYGSSSVPGSCYGEQGSILTKSGTPYTNQSRGCWTDIEQDWRGGNRALSSVSNTEGSSRKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAFSLGMSESQVKVWFQNRRTKWRKKSAVE 196

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Xenopus
Match: soga1 (suppressor of glucose, autophagy associated 1 [Source:Xenbase;Acc:XB-GENE-6049995])

HSP 1 Score: 78.1814 bits (191), Expect = 1.938e-16
Identity = 41/78 (52.56%), Postives = 51/78 (65.38%), Query Frame = 1

Query:  388 CSDTRISSPINDSN--RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSA 615
            C+  RI  P  +    +RK  R +FS  QI  LEK+F + KYLA  ER  LA  L MS+SQVK WFQNRRTKWR+++A
Sbjct:   89 CATRRIGHPYQNRTPPKRKKPRTSFSRLQICELEKRFHRQKYLASAERASLAKALRMSDSQVKTWFQNRRTKWRRQTA 166

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Xenopus
Match: hmx3 (H6 family homeobox 3 [Source:NCBI gene;Acc:780290])

HSP 1 Score: 76.2554 bits (186), Expect = 3.448e-15
Identity = 37/78 (47.44%), Postives = 50/78 (64.10%), Query Frame = 1

Query:  400 RISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATA 633
            R  SP     R+K TR  FS  Q+F LE  F+  +YL+  ER  LA  L ++E+QVK+WFQNRR KW+++ AAE+  A
Sbjct:  167 REESPDKKPCRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAA 244

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BLAST of NK homeobox6-2 vs. Ensembl Mouse
Match: Nkx6-1 (NK6 homeobox 1 [Source:MGI Symbol;Acc:MGI:1206039])

HSP 1 Score: 137.117 bits (344), Expect = 3.804e-37
Identity = 63/95 (66.32%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            C+  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+ATA++    E + ++ 
Sbjct:  222 CTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKG 316

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Mouse
Match: Nkx6-2 (NK6 homeobox 2 [Source:MGI Symbol;Acc:MGI:1352738])

HSP 1 Score: 131.724 bits (330), Expect = 5.665e-36
Identity = 75/167 (44.91%), Postives = 93/167 (55.69%), Query Frame = 1

Query:  253 FKTPHGIMDILSR--------------------------------IENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSP------INDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARR 639
              TPHGI DIL R                                +    P+  + L   +PP+  P      + S   D R++        ++   ++KH+RPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR AAE+A+A++
Sbjct:   54 LGTPHGISDILGRPVGAAGGGLLGSLPRLNGLASSAGVYFGPAAAVARGYPKPLAEL-PGRPPIFWP---GVVQGSPWRDPRLAGSAQAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKK 216

[Close]

Query:  253 FKTPHGIMDILSR--------------------------------IENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSP------INDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARR 639
              TPHGI DIL R                                +    P+  + L   +PP+  P      + S   D R++        ++   ++KH+RPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR AAE+A+A++
Sbjct:   54 LGTPHGISDILGRPVGAAGGGLLGSLPRLNGLASSAGVYFGPAAAVARGYPKPLAEL-PGRPPIFWP---GVVQGSPWRDPRLAGSAQAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKK 216

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Mouse
Match: Nkx6-3 (NK6 homeobox 3 [Source:MGI Symbol;Acc:MGI:1921811])

HSP 1 Score: 128.642 bits (322), Expect = 6.097e-35
Identity = 80/172 (46.51%), Postives = 98/172 (56.98%), Query Frame = 1

Query:  259 TPHGIMDILSR-IENPKPEFYS------------TLNTAKPPLINPIKKSKSE----NSNC-----SDTRISS--------PINDS-NRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAE--IATARRNAGIEVDHIQNQ 675
            TPHGI DILSR +  P     S            +      P +    K+ +E      NC      D R S+        P++D+ +++KHTRPTF+G QIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+SA E   +T R   G   D   ++
Sbjct:   51 TPHGITDILSRPVATPNSSLLSGYPHVAGFGGLSSQGVYYGPQVGSFSKAGNEYPTRTRNCWADTGQDWRGSARPCSNTPDPLSDTIHKKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALEPSSSTPRAPGGASGDRAASE 222

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Mouse
Match: Tlx2 (T cell leukemia, homeobox 2 [Source:MGI Symbol;Acc:MGI:1350935])

HSP 1 Score: 78.1814 bits (191), Expect = 4.691e-16
Identity = 42/93 (45.16%), Postives = 57/93 (61.29%), Query Frame = 1

Query:  400 RISSPINDSN--RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            RI  P  +    +RK  R +FS  Q+  LE++F + KYLA  ER  LA  L M+++QVK WFQNRRTKWR+++A E    R  AG  + H+Q 
Sbjct:  144 RIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQ 236

[Close]

BLAST of NK homeobox6-2 vs. UniProt/SwissProt
Match: sp|Q60554|NKX61_MESAU (Homeobox protein Nkx-6.1 OS=Mesocricetus auratus OX=10036 GN=NKX6-1 PE=1 SV=1)

HSP 1 Score: 137.502 bits (345), Expect = 2.097e-36
Identity = 63/95 (66.32%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            C+  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+ATA++    E + ++ 
Sbjct:  221 CTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKG 315

[Close]

BLAST of NK homeobox6-2 vs. UniProt/SwissProt
Match: sp|O35762|NKX61_RAT (Homeobox protein Nkx-6.1 OS=Rattus norvegicus OX=10116 GN=Nkx6-1 PE=2 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 2.448e-36
Identity = 63/95 (66.32%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            C+  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+ATA++    E + ++ 
Sbjct:  222 CTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKG 316

[Close]

BLAST of NK homeobox6-2 vs. UniProt/SwissProt
Match: sp|P78426|NKX61_HUMAN (Homeobox protein Nkx-6.1 OS=Homo sapiens OX=9606 GN=NKX6-1 PE=1 SV=2)

HSP 1 Score: 137.117 bits (344), Expect = 2.572e-36
Identity = 63/95 (66.32%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            C+  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+ATA++    E + ++ 
Sbjct:  221 CTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKG 315

[Close]

BLAST of NK homeobox6-2 vs. UniProt/SwissProt
Match: sp|Q99MA9|NKX61_MOUSE (Homeobox protein Nkx-6.1 OS=Mus musculus OX=10090 GN=Nkx6-1 PE=1 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 2.661e-36
Identity = 63/95 (66.32%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            C+  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+ATA++    E + ++ 
Sbjct:  222 CTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKG 316

[Close]

BLAST of NK homeobox6-2 vs. UniProt/SwissProt
Match: sp|Q9C056|NKX62_HUMAN (Homeobox protein Nkx-6.2 OS=Homo sapiens OX=9606 GN=NKX6-2 PE=1 SV=2)

HSP 1 Score: 133.265 bits (334), Expect = 1.258e-35
Identity = 74/167 (44.31%), Postives = 93/167 (55.69%), Query Frame = 1

Query:  253 FKTPHGIMDILSR--------------------------------IENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSP------INDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARR 639
              TPHGI DIL R                                +    P+  + L   +PP+  P      + +   D R++ P      ++   ++KH+RPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR A E+A+A++
Sbjct:   54 LGTPHGISDILGRPVGAAGGGLLGGLPRLNGLASSAGVYFGPAAAVARGYPKPLAEL-PGRPPIFWP---GVVQGAPWRDPRLAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKK 216

[Close]

BLAST of NK homeobox6-2 vs. TrEMBL
Match: A0A291FGL2 (NK homeobox6-2 OS=Schmidtea mediterranea OX=79327 GN=nkx6-2 PE=2 SV=1)

HSP 1 Score: 146.747 bits (369), Expect = 1.453e-40
Identity = 98/98 (100.00%), Postives = 98/98 (100.00%), Query Frame = 1

Query:  550 MSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQNQXXXXXXXXXELQTEYKEMNSTTQETDRNYYAPFXXXXXXXXXXXXXXXXXPFLQLK 843
            MSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQNQSSHSSDSDSELQTEYKEMNSTTQETDRNYYAPFSQSLSTDSKDTLSSSSQPFLQLK
Sbjct:    1 MSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQNQSSHSSDSDSELQTEYKEMNSTTQETDRNYYAPFSQSLSTDSKDTLSSSSQPFLQLK 98

[Close]

BLAST of NK homeobox6-2 vs. TrEMBL
Match: A0A3Q1GDY7 (NK6 homeobox 1 OS=Acanthochromis polyacanthus OX=80966 PE=4 SV=1)

HSP 1 Score: 142.895 bits (359), Expect = 6.009e-37
Identity = 76/141 (53.90%), Postives = 94/141 (66.67%), Query Frame = 1

Query:  259 TPHGIMDILSRIENPKPEFYSTLNTAKPPLINPIKKS---KSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            TPHGI DIL+R     P   + L    P     + +S   +     CS  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+A+A++    E + ++ 
Sbjct:   91 TPHGINDILNR-----PTPLAELPGRTPIFWPGVMQSPHWRDARFACSPHQGSVLLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMASAKKKQDSETERLKG 226

[Close]

BLAST of NK homeobox6-2 vs. TrEMBL
Match: A0A5N4EGV4 (Homeobox protein Nkx-6.1 OS=Camelus dromedarius OX=9838 GN=Cadr_000001977 PE=4 SV=1)

HSP 1 Score: 143.665 bits (361), Expect = 7.711e-37
Identity = 75/138 (54.35%), Postives = 89/138 (64.49%), Query Frame = 1

Query:  259 TPHGIMDILSRIENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            TPHGI DILSR     P               P+    +  S     + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+ATA++    E + ++ 
Sbjct:   88 TPHGINDILSR-----PSM-------------PVASGAALPSASPSDQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKG 207

[Close]

BLAST of NK homeobox6-2 vs. TrEMBL
Match: A0A210Q2I9 (Homeobox protein Nkx-6.2 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT17635 PE=4 SV=1)

HSP 1 Score: 142.124 bits (357), Expect = 9.575e-37
Identity = 82/146 (56.16%), Postives = 92/146 (63.01%), Query Frame = 1

Query:  259 TPHGIMDILSRIENPKPEFYSTLNTA------------------KPPLINPIKKSKSENSNCSDTRISSPINDSN-RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARR 639
            TPHGI DIL R         S LN A                  +PP+  P        SN   T  SS + D + ++KHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGMSESQVKVWFQNRRTKWRK+ AAE+ATA++
Sbjct:   86 TPHGICDILGRPSMAALGL-SRLNAAGMYLNSQGRLPKLAELPGRPPIYWP---GVINGSNWRPTGHSSVVVDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYALGMSESQVKVWFQNRRTKWRKKHAAEMATAKK 227

[Close]

BLAST of NK homeobox6-2 vs. TrEMBL
Match: A0A3P7CAP7 (Homeobox domain-containing protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS3553 PE=4 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 4.013e-36
Identity = 63/88 (71.59%), Postives = 72/88 (81.82%), Query Frame = 1

Query:  394 DTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEV 657
            D   ++ ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAYLLGMSESQVKVWFQNRRTKWRK+SAA++AT +      V
Sbjct:   11 DILEATLLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYLLGMSESQVKVWFQNRRTKWRKKSAADMATVKAAQSCSV 98

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Cavefish
Match: nkx6.1 (NK6 homeobox 1 [Source:NCBI gene;Acc:103045404])

HSP 1 Score: 137.502 bits (345), Expect = 9.651e-38
Identity = 64/95 (67.37%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            CS  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR AAE+A+A++    E + ++ 
Sbjct:  185 CSPHQNSVLLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKKKQDSETERLKG 279

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Cavefish
Match: nkx6.3 (NK6 homeobox 3 [Source:NCBI gene;Acc:103024294])

HSP 1 Score: 135.961 bits (341), Expect = 1.134e-37
Identity = 81/174 (46.55%), Postives = 94/174 (54.02%), Query Frame = 1

Query:  250 QFKTPHGIMDILSRIENPKPE------FYSTLN----TAKPPLI--------------------NPIKKSKSENS-------------NCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRN 642
            Q  TPHGI DILSR     P        YST+     T   P +                     P  K +S +               CS+T +  P     R+KHTRPTFSG QIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+SA+E ++ + N
Sbjct:   48 QAGTPHGISDILSRSMMGAPTNTSLIPGYSTMGSFGTTMSSPGVYYNRDYAPAGLGTFPKASAECPGMKGRSSSCWVDGGYDWRGGRQQCSNTDMGHPAETVGRKKHTRPTFSGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSASEPSSTQAN 221

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Cavefish
Match: nkx6.2 (NK6 homeobox 2 [Source:NCBI gene;Acc:103044611])

HSP 1 Score: 134.42 bits (337), Expect = 5.390e-37
Identity = 75/170 (44.12%), Postives = 96/170 (56.47%), Query Frame = 1

Query:  253 FKTPHGIMDILSRIENPKPEFYST------LNTAKPPLINPIKKSK-------------------SENSNCSDTRISSP------INDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQ 669
              TPHGI DIL R      +  +       L  +    +NP   ++                    + S   D R+  P      ++   ++KH+RPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+ATA++    E + ++
Sbjct:   61 LGTPHGISDILGRPIGAAGQLLTGFPRIGGLAGSAGMYLNPAAVARYPKPLAELPGRAPIFWPGVMQASPWRDPRVPCPSQASLMLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKHDSETEKMK 230

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Cavefish
Match: tlx2 (T cell leukemia homeobox 2 [Source:NCBI gene;Acc:103046147])

HSP 1 Score: 75.8702 bits (185), Expect = 2.818e-15
Identity = 41/84 (48.81%), Postives = 53/84 (63.10%), Query Frame = 1

Query:  400 RISSPINDSN--RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNA 645
            RI  P  +    +RK  R +FS  QI  LEK+F + KYLA  ER  LA  L M+++QVK WFQNRRTKWR+++A E    R+ A
Sbjct:  167 RIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERATLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQA 250

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Cavefish
Match: tlx3b (T cell leukemia homeobox 3b [Source:ZFIN;Acc:ZDB-GENE-021021-1])

HSP 1 Score: 75.0998 bits (183), Expect = 4.194e-15
Identity = 41/84 (48.81%), Postives = 53/84 (63.10%), Query Frame = 1

Query:  400 RISSPINDSN--RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNA 645
            RI  P  +    +RK  R +FS  QI  LEK+F + KYLA  ER  LA  L M+++QVK WFQNRRTKWR+++A E    R+ A
Sbjct:  144 RIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKTLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQA 227

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010860.1 (pep scaffold:Pmarinus_7.0:GL477006:70988:76921:1 gene:ENSPMAG00000009840.1 transcript:ENSPMAT00000010860.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 68.9366 bits (167), Expect = 2.949e-15
Identity = 32/64 (50.00%), Postives = 44/64 (68.75%), Query Frame = 1

Query:  430 RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAE 621
            +R  +R  FS  Q   LEK+F+  KY+  P+R +LA +LG++++QVKVWFQNRR KWR    AE
Sbjct:   20 KRAWSRAVFSSLQRKGLEKRFQVQKYVTKPDRRQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAE 83

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Sea Lamprey
Match: tlx1 (T cell leukemia homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-021021-2])

HSP 1 Score: 69.3218 bits (168), Expect = 8.392e-14
Identity = 33/58 (56.90%), Postives = 41/58 (70.69%), Query Frame = 1

Query:  430 RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWR 603
            +RK  R +F+  QI  LEK+F + KYLA  ER  LA  L M+++QVK WFQNRRTKWR
Sbjct:  229 KRKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWR 286

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Sea Lamprey
Match: HMX1 (H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5017])

HSP 1 Score: 65.855 bits (159), Expect = 1.162e-13
Identity = 29/58 (50.00%), Postives = 40/58 (68.97%), Query Frame = 1

Query:  433 RKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRK 606
            +K TR  FS  Q+F LE  F+  +YL+  ER  LA  L ++E+QVK+WFQNRR KW++
Sbjct:    1 KKKTRTVFSRSQVFQLESTFDMKRYLSSAERAGLAASLHLTETQVKIWFQNRRNKWKR 58

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001480.1 (pep scaffold:Pmarinus_7.0:GL487501:66:2428:-1 gene:ENSPMAG00000001338.1 transcript:ENSPMAT00000001480.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 64.6994 bits (156), Expect = 1.568e-13
Identity = 29/56 (51.79%), Postives = 39/56 (69.64%), Query Frame = 1

Query:  430 RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTK 597
            RR+  R  F+  Q+  LE++F + +YL+ PER  LA  LG+SE+QVK WFQNRR K
Sbjct:    5 RRRKARTVFTDSQLSGLERRFVRQRYLSTPERVDLATALGLSETQVKTWFQNRRMK 60

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Sea Lamprey
Match: hhex (pep scaffold:Pmarinus_7.0:GL476649:273574:289580:-1 gene:ENSPMAG00000009445.1 transcript:ENSPMAT00000010429.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:hhex)

HSP 1 Score: 67.3958 bits (163), Expect = 2.407e-13
Identity = 33/61 (54.10%), Postives = 43/61 (70.49%), Query Frame = 1

Query:  424 SNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRK 606
            +++RK  +  FS +Q   LE+KFE+ KYL+  ER  LA LL +SE QVK WFQNRR KWR+
Sbjct:  140 AHKRKGGQVRFSSEQTVELERKFERQKYLSPGERKGLAKLLQLSERQVKTWFQNRRAKWRR 200

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Yeast
Match: PHO2 (Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002264])

HSP 1 Score: 53.5286 bits (127), Expect = 1.954e-8
Identity = 27/72 (37.50%), Postives = 42/72 (58.33%), Query Frame = 1

Query:  394 DTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKR 609
            D   SS  +DS  ++  R    G+ +  L++KFE     +  ER +++ L+GM E  V++WFQNRR K RK+
Sbjct:   64 DMSASSNASDSGPQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKK 135

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Nematostella
Match: EDO30887 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZI0])

HSP 1 Score: 129.798 bits (325), Expect = 9.371e-38
Identity = 62/82 (75.61%), Postives = 68/82 (82.93%), Query Frame = 1

Query:  421 DSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRN-AGIEVDH 663
            D ++RKHTRPTFSG QIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR AAE+   R+  +G E  H
Sbjct:    2 DDSKRKHTRPTFSGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMNIKRKEISGNESSH 83

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Nematostella
Match: ANTH.HBXC.NV (NK-like 20; Predicted protein [Source:UniProtKB/TrEMBL;Acc:Q0N4G2])

HSP 1 Score: 80.1073 bits (196), Expect = 2.170e-19
Identity = 35/58 (60.34%), Postives = 46/58 (79.31%), Query Frame = 1

Query:  433 RKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRK 606
            +K  R TF+G+QIF LEK+FE  KYL   ER+ +A LL ++E+QVK+WFQNRRTKW+K
Sbjct:    1 KKKARTTFTGRQIFELEKQFEAKKYLTATERSDMASLLNVTETQVKIWFQNRRTKWKK 58

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Nematostella
Match: NK-3 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7L1])

HSP 1 Score: 79.337 bits (194), Expect = 3.044e-17
Identity = 39/79 (49.37%), Postives = 54/79 (68.35%), Query Frame = 1

Query:  430 RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRS-AAEIA--TARRNAGIEV 657
            RRK +R  FS QQ+F LE++F   KYL+GPER  LA  L ++E+QVK+WFQNRR K ++R  A+EI   +A +   + V
Sbjct:  129 RRKRSRAAFSHQQVFELERRFSHQKYLSGPERADLAAALKLTETQVKIWFQNRRYKTKRRQLASEICPPSAAKKVAVRV 207

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Nematostella
Match: EDO48767 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI78])

HSP 1 Score: 72.4034 bits (176), Expect = 1.875e-16
Identity = 33/68 (48.53%), Postives = 47/68 (69.12%), Query Frame = 1

Query:  430 RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATA 633
            R+K TR  FS  Q++ LE  F+  +YL+  ER  LA  L ++E+QVK+WFQNRR KW+++ AAE+  A
Sbjct:    1 RKKKTRTVFSRSQVYQLESTFDMKRYLSSSERAGLASQLHLTETQVKIWFQNRRNKWKRQIAAEMEAA 68

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Nematostella
Match: EDO48710 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIH8])

HSP 1 Score: 68.1662 bits (165), Expect = 4.946e-15
Identity = 31/62 (50.00%), Postives = 42/62 (67.74%), Query Frame = 1

Query:  436 KHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAE 621
            K  R  F+  Q+  LE  FE+  Y+ G ER +LA  L +SE+Q+KVWFQNRRTKW+++ A E
Sbjct:    2 KRIRTAFTPTQLLHLENAFEKNHYIVGTERKQLASYLNLSETQIKVWFQNRRTKWKRQQAEE 63

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Medaka
Match: nkx6.1 (NK6 homeobox 1 [Source:NCBI gene;Acc:101156548])

HSP 1 Score: 135.961 bits (341), Expect = 1.713e-37
Identity = 63/95 (66.32%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            CS  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+A+A++    E + ++ 
Sbjct:  149 CSPHQNSVLLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMASAKKKQDSETERLKG 243

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Medaka
Match: nkx6.1 (NK6 homeobox 1 [Source:NCBI gene;Acc:101156548])

HSP 1 Score: 135.961 bits (341), Expect = 2.065e-36
Identity = 63/95 (66.32%), Postives = 76/95 (80.00%), Query Frame = 1

Query:  388 CSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQN 672
            CS  + S  ++   +RKHTRPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+ AAE+A+A++    E + ++ 
Sbjct:  269 CSPHQNSVLLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMASAKKKQDSETERLKG 363

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Medaka
Match: nkx6.2 (NK6 homeobox 2 [Source:NCBI gene;Acc:101156349])

HSP 1 Score: 132.494 bits (332), Expect = 2.956e-36
Identity = 63/104 (60.58%), Postives = 78/104 (75.00%), Query Frame = 1

Query:  376 ENSNCSDTRISSP------INDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQ 669
            + S   D R+  P      ++   ++KH+RPTFSGQQIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRKR AAE+A+A++    E + ++
Sbjct:  131 QGSPWRDPRVPCPAQANIMLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKKKHDSETEKMK 234

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Medaka
Match: nkx6.3 (NK6 homeobox 3 [Source:NCBI gene;Acc:101175486])

HSP 1 Score: 125.176 bits (313), Expect = 1.185e-33
Identity = 60/86 (69.77%), Postives = 70/86 (81.40%), Query Frame = 1

Query:  364 KSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAE 621
            + + + SN S + +  P    +R+KHTRPTFSG QIFALEK FEQTKYLAGPER RLAY LGM+ESQVKVWFQNRRTKWRK+SA+E
Sbjct:  130 RGRQQCSNSSGSLVELP----SRKKHTRPTFSGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSASE 211

[Close]

BLAST of NK homeobox6-2 vs. Ensembl Medaka
Match: nkx3-2 (NK3 homeobox 2 [Source:NCBI gene;Acc:101174110])

HSP 1 Score: 77.411 bits (189), Expect = 4.443e-16
Identity = 40/100 (40.00%), Postives = 58/100 (58.00%), Query Frame = 1

Query:  358 IKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEV 657
            +K     N++ S+    SP     R+K +R  FS  Q+F LE++F   +YL+GPER  LA  L ++E+QVK+WFQNRR K ++R  A    A   A  +V
Sbjct:  114 VKSDSDPNNDSSNLDEKSPDQPKQRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLMASTPAAKKV 213

[Close]

BLAST of NK homeobox6-2 vs. Planmine SMEST
Match: SMESG000023118.1 (SMESG000023118.1)

HSP 1 Score: 471.47 bits (1212), Expect = 2.626e-169
Identity = 272/272 (100.00%), Postives = 272/272 (100.00%), Query Frame = 1

Query:   28 MSYLTIDKLMDMTLRQQHHNSYSNNFPINYSNFHATRFVPELPKELDFSFNTSRWLKXXXXXXXXXXXXXXXENQFKTPHGIMDILSRIENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQNQXXXXXXXXXELQTEYKEMNSTTQETDRNYYAPFXXXXXXXXXXXXXXXXXPFLQLK 843
            MSYLTIDKLMDMTLRQQHHNSYSNNFPINYSNFHATRFVPELPKELDFSFNTSRWLKSIITSTSIPTSPQPSENQFKTPHGIMDILSRIENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQNQSSHSSDSDSELQTEYKEMNSTTQETDRNYYAPFSQSLSTDSKDTLSSSSQPFLQLK
Sbjct:    1 MSYLTIDKLMDMTLRQQHHNSYSNNFPINYSNFHATRFVPELPKELDFSFNTSRWLKSIITSTSIPTSPQPSENQFKTPHGIMDILSRIENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQNQSSHSSDSDSELQTEYKEMNSTTQETDRNYYAPFSQSLSTDSKDTLSSSSQPFLQLK 272

[Close]

BLAST of NK homeobox6-2 vs. Planmine SMEST
Match: SMESG000023118.1 (SMESG000023118.1)

HSP 1 Score: 452.21 bits (1162), Expect = 5.723e-162
Identity = 263/263 (100.00%), Postives = 263/263 (100.00%), Query Frame = 1

Query:   55 MDMTLRQQHHNSYSNNFPINYSNFHATRFVPELPKELDFSFNTSRWLKXXXXXXXXXXXXXXXENQFKTPHGIMDILSRIENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQNQXXXXXXXXXELQTEYKEMNSTTQETDRNYYAPFXXXXXXXXXXXXXXXXXPFLQLK 843
            MDMTLRQQHHNSYSNNFPINYSNFHATRFVPELPKELDFSFNTSRWLKSIITSTSIPTSPQPSENQFKTPHGIMDILSRIENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQNQSSHSSDSDSELQTEYKEMNSTTQETDRNYYAPFSQSLSTDSKDTLSSSSQPFLQLK
Sbjct:    1 MDMTLRQQHHNSYSNNFPINYSNFHATRFVPELPKELDFSFNTSRWLKSIITSTSIPTSPQPSENQFKTPHGIMDILSRIENPKPEFYSTLNTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARRNAGIEVDHIQNQSSHSSDSDSELQTEYKEMNSTTQETDRNYYAPFSQSLSTDSKDTLSSSSQPFLQLK 263

[Close]

BLAST of NK homeobox6-2 vs. Planmine SMEST
Match: SMESG000002774.1 (SMESG000002774.1)

HSP 1 Score: 130.568 bits (327), Expect = 4.652e-35
Identity = 82/163 (50.31%), Postives = 92/163 (56.44%), Query Frame = 1

Query:  259 TPHGIMDIL------------------------------------SRIENPKPEF---YSTLNTAK---PPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAE 621
            TPHGIMDIL                                    S I+  KP F    S L  AK   PP INP   S+     C  T++     D ++RKHTRPTFSGQQIFALEK FEQT+YLAGPER RLA+LLGMSESQVKVWFQNRRTKWRK+S  +
Sbjct:  100 TPHGIMDILKSSQSADDEKSNSQIDTEPKQQSNNPCQNRSIEFEKSFIDICKPTFGIDTSALLWAKAGLPPNINPELWSRQF---CQPTQLLD--RDCSKRKHTRPTFSGQQIFALEKTFEQTRYLAGPERARLAFLLGMSESQVKVWFQNRRTKWRKKSCTD 257

[Close]

BLAST of NK homeobox6-2 vs. Planmine SMEST
Match: SMESG000021901.1 (SMESG000021901.1)

HSP 1 Score: 80.4925 bits (197), Expect = 2.852e-17
Identity = 36/71 (50.70%), Postives = 51/71 (71.83%), Query Frame = 1

Query:  427 NRRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATARR 639
            +++K +R TFSG+QI  LEK+FE  KYL+  ER  LA  L ++E+QVK+WFQNRRTKW+K+       A++
Sbjct:  145 DKKKKSRTTFSGRQICELEKQFELKKYLSSAERAELASSLNVTETQVKIWFQNRRTKWKKQENITTVLAQQ 215

[Close]

BLAST of NK homeobox6-2 vs. Planmine SMEST
Match: SMESG000033792.1 (SMESG000033792.1)

HSP 1 Score: 80.8777 bits (198), Expect = 4.934e-17
Identity = 33/68 (48.53%), Postives = 49/68 (72.06%), Query Frame = 1

Query:  430 RRKHTRPTFSGQQIFALEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIATA 633
            R+K TR  FS  Q+F LE  F+  +YL+  ER+ LA+ L ++E+QVK+WFQNRR KW+++ +AE+  A
Sbjct:  189 RKKKTRTVFSRNQVFQLESTFDMKRYLSSSERSSLAHALQLTETQVKIWFQNRRNKWKRQLSAELEVA 256

The following BLAST results are available for this feature:

BLAST of NK homeobox6-2 vs. Ensembl Human
BLAST of NK homeobox6-2 vs. Ensembl Celegans
BLAST of NK homeobox6-2 vs. Ensembl Fly
BLAST of NK homeobox6-2 vs. Ensembl Zebrafish
BLAST of NK homeobox6-2 vs. Ensembl Xenopus
BLAST of NK homeobox6-2 vs. Ensembl Mouse
BLAST of NK homeobox6-2 vs. UniProt/SwissProt
BLAST of NK homeobox6-2 vs. TrEMBL
BLAST of NK homeobox6-2 vs. Ensembl Cavefish
BLAST of NK homeobox6-2 vs. Ensembl Sea Lamprey
BLAST of NK homeobox6-2 vs. Ensembl Yeast
BLAST of NK homeobox6-2 vs. Ensembl Nematostella
BLAST of NK homeobox6-2 vs. Ensembl Medaka
BLAST of NK homeobox6-2 vs. Planmine SMEST

BLAST of NK homeobox6-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NKX6-1	5.356e-37	66.32	NK6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7839]	[more]
NKX6-2	2.620e-36	44.31	NK6 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:19321]	[more]
NKX6-3	5.761e-34	47.77	NK6 homeobox 3 [Source:HGNC Symbol;Acc:HGNC:26328]	[more]
TLX2	4.279e-16	45.65	T cell leukemia homeobox 2 [Source:HGNC Symbol;Acc...	[more]
TLX3	8.281e-15	48.15	T cell leukemia homeobox 3 [Source:HGNC Symbol;Acc...	[more]

BLAST of NK homeobox6-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cog-1	4.987e-28	63.29	COG-1B [Source:UniProtKB/TrEMBL;Acc:G5EGF2]	[more]
cog-1	7.900e-27	63.29	COG-1B [Source:UniProtKB/TrEMBL;Acc:G5EGF2]	[more]
ceh-9	3.972e-19	42.74	Homeobox protein ceh-9 [Source:UniProtKB/Swiss-Pr...	[more]
ceh-1	7.643e-14	46.97	Homeobox protein ceh-1 [Source:UniProtKB/Swiss-Pr...	[more]
tab-1	1.779e-13	40.00	pep chromosome:WBcel235:II:6803758:6804863:1 gene:...	[more]

BLAST of NK homeobox6-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HGTX	4.849e-38	67.96	gene:FBgn0040318 transcript:FBtr0075720	[more]
NK7.1	4.680e-19	60.32	gene:FBgn0024321 transcript:FBtr0306742	[more]
NK7.1	4.680e-19	60.32	gene:FBgn0024321 transcript:FBtr0347151	[more]
NK7.1	4.680e-19	60.32	gene:FBgn0024321 transcript:FBtr0082942	[more]
NK7.1	4.680e-19	60.32	gene:FBgn0024321 transcript:FBtr0082941	[more]

BLAST of NK homeobox6-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nkx6.1	7.756e-38	67.37	NK6 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-040718-17...	[more]
nkx6.2	2.728e-37	45.88	NK6 homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-070626-1]	[more]
nkx6.3	2.140e-34	45.45	NK6 homeobox 3 [Source:ZFIN;Acc:ZDB-GENE-070810-7]	[more]
nkx6.3	8.091e-34	75.68	NK6 homeobox 3 [Source:ZFIN;Acc:ZDB-GENE-070810-7]	[more]
hmx3b	5.103e-17	44.19	H6 family homeobox 3b [Source:ZFIN;Acc:ZDB-GENE-13...	[more]

BLAST of NK homeobox6-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
zfand1	1.441e-37	45.40	zinc finger AN1-type containing 1 [Source:Xenbase;...	[more]
meis1	2.696e-37	66.32	Meis homeobox 1 [Source:Xenbase;Acc:XB-GENE-479439...	[more]
znf608	1.866e-33	51.63	zinc finger protein 608 [Source:Xenbase;Acc:XB-GEN...	[more]
soga1	1.938e-16	52.56	suppressor of glucose, autophagy associated 1 [Sou...	[more]
hmx3	3.448e-15	47.44	H6 family homeobox 3 [Source:NCBI gene;Acc:780290]	[more]

BLAST of NK homeobox6-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Nkx6-1	3.804e-37	66.32	NK6 homeobox 1 [Source:MGI Symbol;Acc:MGI:1206039]	[more]
Nkx6-2	5.665e-36	44.91	NK6 homeobox 2 [Source:MGI Symbol;Acc:MGI:1352738]	[more]
Nkx6-2	5.665e-36	44.91	NK6 homeobox 2 [Source:MGI Symbol;Acc:MGI:1352738]	[more]
Nkx6-3	6.097e-35	46.51	NK6 homeobox 3 [Source:MGI Symbol;Acc:MGI:1921811]	[more]
Tlx2	4.691e-16	45.16	T cell leukemia, homeobox 2 [Source:MGI Symbol;Acc...	[more]

BLAST of NK homeobox6-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q60554\|NKX61_MESAU	2.097e-36	66.32	Homeobox protein Nkx-6.1 OS=Mesocricetus auratus O...	[more]
sp\|O35762\|NKX61_RAT	2.448e-36	66.32	Homeobox protein Nkx-6.1 OS=Rattus norvegicus OX=1...	[more]
sp\|P78426\|NKX61_HUMAN	2.572e-36	66.32	Homeobox protein Nkx-6.1 OS=Homo sapiens OX=9606 G...	[more]
sp\|Q99MA9\|NKX61_MOUSE	2.661e-36	66.32	Homeobox protein Nkx-6.1 OS=Mus musculus OX=10090 ...	[more]
sp\|Q9C056\|NKX62_HUMAN	1.258e-35	44.31	Homeobox protein Nkx-6.2 OS=Homo sapiens OX=9606 G...	[more]

BLAST of NK homeobox6-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A291FGL2	1.453e-40	100.00	NK homeobox6-2 OS=Schmidtea mediterranea OX=79327 ...	[more]
A0A3Q1GDY7	6.009e-37	53.90	NK6 homeobox 1 OS=Acanthochromis polyacanthus OX=8...	[more]
A0A5N4EGV4	7.711e-37	54.35	Homeobox protein Nkx-6.1 OS=Camelus dromedarius OX...	[more]
A0A210Q2I9	9.575e-37	56.16	Homeobox protein Nkx-6.2 OS=Mizuhopecten yessoensi...	[more]
A0A3P7CAP7	4.013e-36	71.59	Homeobox domain-containing protein OS=Schistocepha...	[more]

BLAST of NK homeobox6-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nkx6.1	9.651e-38	67.37	NK6 homeobox 1 [Source:NCBI gene;Acc:103045404]	[more]
nkx6.3	1.134e-37	46.55	NK6 homeobox 3 [Source:NCBI gene;Acc:103024294]	[more]
nkx6.2	5.390e-37	44.12	NK6 homeobox 2 [Source:NCBI gene;Acc:103044611]	[more]
tlx2	2.818e-15	48.81	T cell leukemia homeobox 2 [Source:NCBI gene;Acc:1...	[more]
tlx3b	4.194e-15	48.81	T cell leukemia homeobox 3b [Source:ZFIN;Acc:ZDB-G...	[more]

BLAST of NK homeobox6-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000010860.1	2.949e-15	50.00	pep scaffold:Pmarinus_7.0:GL477006:70988:76921:1 g...	[more]
tlx1	8.392e-14	56.90	T cell leukemia homeobox 1 [Source:ZFIN;Acc:ZDB-GE...	[more]
HMX1	1.162e-13	50.00	H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:...	[more]
ENSPMAT00000001480.1	1.568e-13	51.79	pep scaffold:Pmarinus_7.0:GL487501:66:2428:-1 gene...	[more]
hhex	2.407e-13	54.10	pep scaffold:Pmarinus_7.0:GL476649:273574:289580:-...	[more]

BLAST of NK homeobox6-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
PHO2	1.954e-8	37.50	Homeobox transcription factor; regulatory targets ...	[more]

BLAST of NK homeobox6-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO30887	9.371e-38	75.61	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
ANTH.HBXC.NV	2.170e-19	60.34	NK-like 20; Predicted protein [Source:UniProtKB/T...	[more]
NK-3	3.044e-17	49.37	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48767	1.875e-16	48.53	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48710	4.946e-15	50.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of NK homeobox6-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nkx6.1	1.713e-37	66.32	NK6 homeobox 1 [Source:NCBI gene;Acc:101156548]	[more]
nkx6.1	2.065e-36	66.32	NK6 homeobox 1 [Source:NCBI gene;Acc:101156548]	[more]
nkx6.2	2.956e-36	60.58	NK6 homeobox 2 [Source:NCBI gene;Acc:101156349]	[more]
nkx6.3	1.185e-33	69.77	NK6 homeobox 3 [Source:NCBI gene;Acc:101175486]	[more]
nkx3-2	4.443e-16	40.00	NK3 homeobox 2 [Source:NCBI gene;Acc:101174110]	[more]

BLAST of NK homeobox6-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000023118.1	2.626e-169	100.00	SMESG000023118.1	[more]
SMESG000023118.1	5.723e-162	100.00	SMESG000023118.1	[more]
SMESG000002774.1	4.652e-35	50.31	SMESG000002774.1	[more]
SMESG000021901.1	2.852e-17	50.70	SMESG000021901.1	[more]
SMESG000033792.1	4.934e-17	48.53	SMESG000033792.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30016686 ID=SMED30016686|Name=NK homeobox6-2|organism=Schmidtea mediterranea sexual|type=transcript|length=960bp
TGATAAAGGCATTAATTTAAAATCGCAATGTCATATCTAACGATCGATAA
ACTGATGGACATGACCCTGAGACAACAGCATCACAATTCGTATTCGAATA
ATTTCCCAATCAATTATTCGAATTTCCACGCAACGAGATTCGTGCCAGAA
TTGCCGAAAGAATTGGATTTTTCCTTCAACACTTCTCGATGGTTGAAATC
GATAATCACATCAACATCGATTCCAACGAGTCCTCAGCCGTCAGAAAATC
AATTCAAAACCCCTCATGGAATCATGGACATTCTCAGCCGGATTGAAAAC
CCGAAACCGGAATTCTACAGCACTCTCAACACCGCAAAACCGCCTTTGAT
AAATCCAATAAAAAAATCCAAATCAGAAAATTCAAACTGCAGCGATACGA
GAATATCGTCACCAATAAACGATTCAAATCGTCGCAAGCATACCAGGCCA
ACATTTTCCGGACAACAGATTTTTGCGTTGGAAAAGAAATTCGAACAAAC
AAAATACCTCGCTGGACCGGAACGAACAAGACTGGCGTATTTATTGGGAA
TGTCAGAAAGTCAAGTTAAGGTATGGTTTCAAAATCGTCGAACGAAATGG
CGTAAAAGAAGTGCAGCAGAAATTGCGACTGCGAGGAGGAATGCAGGAAT
AGAGGTAGATCATATACAAAATCAGTCATCACACTCATCAGACAGTGATA
GTGAGCTGCAAACCGAATATAAAGAAATGAATTCAACAACGCAAGAGACT
GATCGGAATTATTATGCGCCATTTTCACAATCTTTGTCCACAGATTCAAA
AGATACTTTATCTTCAAGTTCTCAACCATTTCTGCAATTAAAATGATGTA
TAAATTTATCCATGTGCATTAAAAGCGTATTGAATACGAATTGTTATTGT
AATAATCTCTTGTTTTCGAAATGTTTACTGAAAAACTCGTTAGAAAATAT
TTGTTGTCGT

protein sequence of SMED30016686-orf-1

>SMED30016686-orf-1 ID=SMED30016686-orf-1|Name=SMED30016686-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=273bp
MSYLTIDKLMDMTLRQQHHNSYSNNFPINYSNFHATRFVPELPKELDFSF
NTSRWLKSIITSTSIPTSPQPSENQFKTPHGIMDILSRIENPKPEFYSTL
NTAKPPLINPIKKSKSENSNCSDTRISSPINDSNRRKHTRPTFSGQQIFA
LEKKFEQTKYLAGPERTRLAYLLGMSESQVKVWFQNRRTKWRKRSAAEIA
TARRNAGIEVDHIQNQSSHSSDSDSELQTEYKEMNSTTQETDRNYYAPFS
QSLSTDSKDTLSSSSQPFLQLK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000240	body wall musculature

Vocabulary: **INTERPRO**
Term	Definition
IPR000047	HTH_motif
IPR020479	Homeobox_metazoa
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682	chromatin binding
GO:0003700	transcription factor activity, sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001764	neuron migration
GO:0003309	type B pancreatic cell differentiation
GO:0003323	type B pancreatic cell development
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007224	smoothened signaling pathway
GO:0007275	multicellular organism development
GO:0008283	cell proliferation
GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0021953	central nervous system neuron differentiation
GO:0022008	neurogenesis
GO:0030154	cell differentiation
GO:0030516	regulation of axon extension
GO:0031018	endocrine pancreas development
GO:0032024	positive regulation of insulin secretion
GO:0035094	response to nicotine
GO:0042493	response to drug
GO:0044342	type B pancreatic cell proliferation
GO:0045666	positive regulation of neuron differentiation
GO:0045686	negative regulation of glial cell differentiation
GO:0045687	positive regulation of glial cell differentiation
GO:0048709	oligodendrocyte differentiation
GO:0050796	regulation of insulin secretion
GO:0071345	cellular response to cytokine stimulus
GO:0071375	cellular response to peptide hormone stimulus
GO:2001222	regulation of neuron migration

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0070062	extracellular exosome

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR020479	Homeobox domain, metazoa	PRINTS	PR00024	HOMEOBOX	coord: 173..183 score: 51.41 coord: 158..169 score: 36.03 coord: 183..192 score: 73.73
IPR000047	Helix-turn-helix motif	PRINTS	PR00031	HTHREPRESSR	coord: 174..190 score: 57.8 coord: 165..174 score: 46.41
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 134..198 e-value: 1.8E-22 score: 90.7
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 137..193 e-value: 1.7E-20 score: 72.6
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 134..194 score: 19.742
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 137..195 e-value: 1.17392E-17 score: 73.0464
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 135..199 e-value: 4.9E-24 score: 85.8
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 208..272
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 210..272
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 112..144
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 112..129
None	No IPR available	PANTHER	PTHR24340:SF35	GTX/NKX6B-LIKE HOMEODOMAIN PROTEIN	coord: 119..236
None	No IPR available	PANTHER	PTHR24340	FAMILY NOT NAMED	coord: 119..236
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 169..192
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 123..194