Thimet oligopeptidase

Overview
NameThimet oligopeptidase
Smed IDSMED30016571
Length (bp)2153
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Thimet oligopeptidase (SMED30016571) t-SNE clustered cells

Violin plots show distribution of expression levels for Thimet oligopeptidase (SMED30016571) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Thimet oligopeptidase (SMED30016571) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Thimet oligopeptidase (SMED30016571) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30016571

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Smed sexual biotypeSMED30016571h1SMcG0019644 Contig44491uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30016571h1SMcG0019644 Contig44491newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
gutSMED30016571h1SMcG0019644 dd_Smed_v4_3546_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30016571h1SMcG0019644 dd_Smed_v4_3546_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30016571h1SMcG0019644 dd_Smed_v4_3546_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30016571h1SMcG0019644 dd_Smed_v4_3546_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30016571h1SMcG0019644 Contig29443uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30016571h1SMcG0019644 Contig29443newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Thimet oligopeptidase vs. Ensembl Human
Match: THOP1 (thimet oligopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:11793])

HSP 1 Score: 643.654 bits (1659), Expect = 0.000e+0
Identity = 322/662 (48.64%), Postives = 436/662 (65.86%), Query Frame = 2
Query:  125 NFDWITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLR 2098
            +  W    ++ + R   L  +    YD +G+++   ++++   + LAD E+ +  Q ++L   Q V P K  R ASTEADK LS+  V++SMR+DV+ + V L+E +    L  ++ +Y+++ IK G+  GLHL    ++ ++ I K+LS L IDF KNL+E+ T L F++ EL G  E F+ SL K E  + K KV+LKYPHYFP++K   +PETRR++E AFN RCKEEN  +LK ++ LRA+K++LLGF THADYVL   MAK ++ V  FL EL +KL  +  +E +  L  K+  CER  + F+ RI AWDMRY+MN  EE  + V+   L++YFP+  V  G+  IY+ LLGL F   EG   WH  V L+  +DA    ++G F+LDLYPR+GKYGHA    LQ G    C   +  RQ+ + AM+ANFTK T D PSLL HDEV T+FHEFGHVMH +C Q +F   +   VERDFVE PSQMLENW W+ E L  MS HY+TG  +  ELL  L+ SR AN  + N RQI LA  DQ +HT+TD DP E Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+LN+K G DYR  IL+PG S+DA+ +++ FLGR P QDAFL   GL+
Sbjct:   23 DLRWDLSAQQIEERTRELIEQTKRVYDQVGTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKME--DGKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPG----CLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQ 678          
BLAST of Thimet oligopeptidase vs. Ensembl Human
Match: THOP1 (thimet oligopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:11793])

HSP 1 Score: 584.334 bits (1505), Expect = 0.000e+0
Identity = 287/551 (52.09%), Postives = 375/551 (68.06%), Query Frame = 2
Query:  449 LPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLR 2098
            L  ++ +Y+++ IK G+  GLHL    ++ ++ I K+LS L IDF KNL+E+ T L F++ EL G  E F+ SL K E  + K KV+LKYPHYFP++K   +PETRR++E AFN RCKEEN  +LK ++ LRA+K++LLGF THADYVL   MAK ++ V  FL EL +KL  +  +E +  L  K+  CER  + F+ RI AWDMRY+MN  EE  + V+   L++YFP+  V  G+  IY+ LLGL F   EG   WH  V L+  +DA    ++G F+LDLYPR+GKYGHA    LQ G    C   +  RQ+ + AM+ANFTK T D PSLL HDEV T+FHEFGHVMH +C Q +F   +   VERDFVE PSQMLENW W+ E L  MS HY+TG  +  ELL  L+ SR AN  + N RQI LA  DQ +HT+TD DP E Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+LN+K G DYR  IL+PG S+DA+ +++ FLGR P QDAFL   GL+
Sbjct:   13 LRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKME--DGKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPG----CLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQ 557          
BLAST of Thimet oligopeptidase vs. Ensembl Human
Match: NLN (neurolysin [Source:HGNC Symbol;Acc:HGNC:16058])

HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0
Identity = 311/658 (47.26%), Postives = 423/658 (64.29%), Query Frame = 2
Query:  134 WITKVEEFKYRAENLKYEALHKYDVIG--SEKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFD-GKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKV-EGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            W    E+ K R E L  +    YD +G    + +T++   + LAD E+K+  +  +L   Q V  DK  R ASTEADK LS   +++SMR D+F++ V L+E  D GK+  ++ +Y++K IK GK  GLHL E V+ E++S+ K +S L IDF KNL+E++T L FS  EL    + FI SL K  TD++K K++LKYPHYFP+MK   +PETRR+ME AFN+RCKEEN  +L+ +L LR K AKLLG++THAD+VL    AK    V  FL +L +KL  +   E    L  KK+ C+    +++ +I+AWD+ Y+M   EE  +S++ E L++YFPI+ V  G+   Y+ LLGL FE++ +   W+ SV L+ VKD     +LG F+LDLYPR+GKY HA    LQ G    C + +  R + V A++ NF++    +PSLL HDEV T+FHEFGHVMH IC QTDF   +  +VE DFVE PSQMLENW W  +SL+ +S HYK G P+ D+LL  L+ SR+ N  +   RQI L+  DQ +HT T +D    Y     + + +  T GTNMPATFGH+AGGYD QYYGYLWSEVF+ DMF S F+KEG++N + G  YR +ILKPG S D  +++ +FL R PNQ AFL   GL
Sbjct:   50 WDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMSMRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEK--TDDDKYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPG----CLLPDGSRMMAVAALVVNFSQPVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGL 701          
BLAST of Thimet oligopeptidase vs. Ensembl Human
Match: NLN (neurolysin [Source:HGNC Symbol;Acc:HGNC:16058])

HSP 1 Score: 553.903 bits (1426), Expect = 0.000e+0
Identity = 296/603 (49.09%), Postives = 397/603 (65.84%), Query Frame = 2
Query:  293 LLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFD-GKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKV-EGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            +L   Q V  DK  R ASTEADK LS   +++SMR D+F++ V L+E  D GK+  ++ +Y++K IK GK  GLHL E V+ E++S+ K +S L IDF KNL+E++T L FS  EL    + FI SL K  TD++K K++LKYPHYFP+MK   +PETRR+ME AFN+RCKEEN  +L+ +L LR K AKLLG++THAD+VL    AK    V  FL +L +KL  +   E    L  KK+ C+    +++ +I+AWD+ Y+M   EE  +S++ E L++YFPI+ V  G+   Y+ LLGL FE++ +   W+ SV L+ VKD     +LG F+LDLYPR+GKY HA    LQ G    C + +  R + V A++ NF++    +PSLL HDEV T+FHEFGHVMH IC QTDF   +  +VE DFVE PSQMLENW W  +SL+ +S HYK G P+ D+LL  L+ SR+ N  +   RQI L+  DQ +HT T +D    Y     + + +  T GTNMPATFGH+AGGYD QYYGYLWSEVF+ DMF S F+KEG++N + G  YR +ILKPG S D  +++ +FL R PNQ AFL   GL
Sbjct:    1 MLDFPQHVSSDKEVRAASTEADKRLSRFDIEMSMRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEK--TDDDKYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPG----CLLPDGSRMMAVAALVVNFSQPVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGL 597          
BLAST of Thimet oligopeptidase vs. Ensembl Human
Match: NLN (neurolysin [Source:HGNC Symbol;Acc:HGNC:16058])

HSP 1 Score: 345.125 bits (884), Expect = 1.466e-111
Identity = 195/433 (45.03%), Postives = 264/433 (60.97%), Query Frame = 2
Query:  800 KEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKV-EGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            KEEN  +L+ +L LR K AKLLG++THAD+VL    AK    V  FL +L +KL  +   E    L  KK+ C+    +++ +I+AWD+ Y+M   EE  +S++ E L++YFPI+ V  G+   Y+ LLGL FE++ +   W+ SV L+ VKD     +LG F+LDLYPR+GKY HA    LQ G    C + +  R + V A++ NF++    +PSLL HDE                  TDF   +  +VE DFVE PSQMLENW W  +SL+ +S HYK G P+ D+LL  L+ SR+ N  +   RQI L+  DQ +HT T +D    Y     + + +  T GTNMPATFGH+AGGYD QYYGYLWSEVF+ DMF S F+KEG++N + G  YR +ILKPG S D  +++ +FL R PNQ AFL   GL
Sbjct:    1 KEENTIILQQLLPLRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPG----CLLPDGSRMMAVAALVVNFSQPVAGRPSLLRHDE------------------TDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGL 411          
BLAST of Thimet oligopeptidase vs. Ensembl Celegans
Match: Y67H2A.7 (pep chromosome:WBcel235:IV:13303746:13310818:1 gene:WBGene00013464.1 transcript:Y67H2A.7a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y67H2A.7)

HSP 1 Score: 78.5666 bits (192), Expect = 9.190e-15
Identity = 130/634 (20.50%), Postives = 261/634 (41.17%), Query Frame = 2
Query:  260 DFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKK-----IKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAW---DMRYFMNVYEEQLFSVNH--EKLRDYFPIDKVRRGMFEIYERLLGLKFEK---VEGEFWHHS--VELFGVKDANDTSLLGYFFLDLYPRDGK-YGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTG----XXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPV--------EVYQSVVKQYM-NIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLG-RPPNQD 2071
            D   +    + L    + +H +  FR+A+ +  +   +L   L+    ++ Q +K  EI +    +  +  +DK+     + D +  G+HL ++ +++   +S E+      F++N     ++ +F                       ++ K  L    Y P+     L  ++R+M +    R  +     L+ ++  R + ++L GF + A     N + +    V  FL  + EK      +E++  +    +  ++   + NN I      D+ + M++Y E  + +    ++   +F  + +  G   + +RL G++  +   + GE W+ S  ++L  V + N+   LG  ++D+  R  K  G    T+     L+      PI    V+++      S++ + S ++     T FHE GH MH+I  +T + ++      +DF E PS ++E +      L +M+   +      E L  E    LL SR +  A+   +Q     +D  +H       +        E++  ++ + M +I  +  +     F H    Y A+YY YL +   A  ++  RF  +   + K G  + E+    G    A  L++  LG RP   D
Sbjct:   80 DISNEICKSADLAECVRQLHSEPEFRNAAEDVSRNFCELVESLNTNTALY-QKLKSSEITE----SSRLDDVDKRTLTLLLDDFEQSGVHLKDNQKEQFVQLSSEIFDAGARFQQNCDRIVSVGKF-----------------------DQAKYGLPSQIYTPVSNS--LDRSKRKMVYNTFYRHDDIQESYLQHLISSRHQLSQLTGFESFAHRAQRNSLLENYDTVRSFLWGVVEKCRGAFEKELAVLIDVSAQCSQQDNNNGNNEISTIAEHDLGFLMHLYRESAYDIAQVSQQSSPFFTFNSIWNGFSTLTQRLYGVRLIEEPLISGEMWNSSGVMKLQAVDEQNNE--LGVIYVDVSIRPEKAVGDCHYTVRCSKQLSDGTWQMPI---LVLSLGLVDGHSSQWRNSRVSFHSAETMFHELGHAMHSILGRTKYQHVAGTRCPQDFSEIPSNLMEYFF---SDLGVMTDIIRRTDRPEEQLSIESAATLLASRHSFTAIETVQQAAYGLYDLEVHGPIAAPQIASGRMTTTELFHDIMNKTMPHIQRSPDSAFQHRFHHTV-QYGAKYYSYLVARASACLIWQQRFLNDP-FSRKWGDCWAEVQSHGGGHHPA-VLLEKILGFRPTEND 672          
BLAST of Thimet oligopeptidase vs. Ensembl Celegans
Match: Y67H2A.7 (pep chromosome:WBcel235:IV:13307113:13310802:1 gene:WBGene00013464.1 transcript:Y67H2A.7b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y67H2A.7)

HSP 1 Score: 70.0922 bits (170), Expect = 2.158e-12
Identity = 99/442 (22.40%), Postives = 188/442 (42.53%), Query Frame = 2
Query:  821 LKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDA---WDMRYFMNVYEEQLFSVNH--EKLRDYFPIDKVRRGMFEIYERLLGLKFEK---VEGEFWHHS--VELFGVKDANDTSLLGYFFLDLYPRDGK-YGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTG----XXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPV--------EVYQSVVKQYM-NIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLG-RPPNQD 2071
            L+ ++  R + ++L GF + A     N + +    V  FL  + EK      +E++  +    +  ++   + NN I      D+ + M++Y E  + +    ++   +F  + +  G   + +RL G++  +   + GE W+ S  ++L  V + N+   LG  ++D+  R  K  G    T+     L+      PI    V+++      S++ + S ++     T FHE GH MH+I  +T + ++      +DF E PS ++E +      L +M+   +      E L  E    LL SR +  A+   +Q     +D  +H       +        E++  ++ + M +I  +  +     F H    Y A+YY YL +   A  ++  RF  +   + K G  + E+    G    A  L++  LG RP   D
Sbjct:   17 LQHLISSRHQLSQLTGFESFAHRAQRNSLLENYDTVRSFLWGVVEKCRGAFEKELAVLIDVSAQCSQQDNNNGNNEISTIAEHDLGFLMHLYRESAYDIAQVSQQSSPFFTFNSIWNGFSTLTQRLYGVRLIEEPLISGEMWNSSGVMKLQAVDEQNNE--LGVIYVDVSIRPEKAVGDCHYTVRCSKQLSDGTWQMPI---LVLSLGLVDGHSSQWRNSRVSFHSAETMFHELGHAMHSILGRTKYQHVAGTRCPQDFSEIPSNLMEYFF---SDLGVMTDIIRRTDRPEEQLSIESAATLLASRHSFTAIETVQQAAYGLYDLEVHGPIAAPQIASGRMTTTELFHDIMNKTMPHIQRSPDSAFQHRFHHTV-QYGAKYYSYLVARASACLIWQQRFLNDP-FSRKWGDCWAEVQSHGGGHHPA-VLLEKILGFRPTEND 447          
BLAST of Thimet oligopeptidase vs. Ensembl Celegans
Match: ZK550.3 (pep chromosome:WBcel235:IV:17250131:17254964:1 gene:WBGene00013997.1 transcript:ZK550.3.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK550.3)

HSP 1 Score: 66.6254 bits (161), Expect = 4.460e-11
Identity = 134/649 (20.65%), Postives = 263/649 (40.52%), Query Frame = 2
Query:  233 FQKIAENL--ADFELKFATQSHLLSLYQSVHPD--KTFRDASTEADKIL-SDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGL-HLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSL----KYPH-YFPIMKHAILPETRRQMEFAFNSRCKEE-----NGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG---EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQI----GGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDF-----GYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNT-RQICLASFDQIIHTKTDVDP---VEVYQSVVKQYMNIPVTDGTNMPATFGHMAG--GYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAF 2077
            F+ + E L   ++E+ FA Q+ +L +     PD  +   DA     KI+ +  +++    KD  D   +L E  DG    QS + ++  + + K  GL   D+  RK + S SK +   +  +   +   N    F + + +   ++    L K   DE   +         PH  +P M++    + R      + S+   +     N   ++ +       AK LG+++ A++ L+N+MA   + V  F+  L+ ++  +  + +  +  +    CE +       + A+DM Y      E  + VN   L ++FP     + +  +   +  L+F+ +     E  H  V ++ V D       G  ++D Y R  K G   V L +      GL+            +V  + +    T + PSLL+H ++      FG  +  +  Q+ +      +   +  + D  +     L+ +  +   L  +S  ++  +    E   N +   ++  ++  T R +  + FD  I+   D      +++Y+ + ++Y           P +F  +     + + YY  LW+E+ A D+  +  +++     +TG   +  IL  GS   A EL K F GR P+  A 
Sbjct:  122 FENVVEPLLTEEYEVNFAFQTLVLKMLTD-WPDCNRKLFDADLHHIKIMCARDQMEKLTNKDFQDAIKQLYEAKDGLSEWQS-RLLEWYLLEIKASGLDKHDDKTRKVLGSWSKFVDEYRSKYITGVMSTNDQQTFVVTDQKVIKDAPPHVLQKLAVDEQNWESGPWRGRMTPHTIYPFMQYCGDRQLRATAWEKWTSKAGFDHDFYNNSINIEELRHNNEGLAKTLGYSSVAEHRLANKMAASPETVRGFINALQRRIRPVVIDRMESWSAWAGR-CELI----TGELQAYDMPYVCRKEAEHHYDVNPLDLMNHFPFWPTFQNIMGVIGHIFNLEFKDITDKGLEKAHADVRIYSVGDKFSGQHYGRLYIDPYDRQNKRGGWNVMLARPESKERGLD-----------KIVYFIGSAIAPTSNGPSLLHHQQLQQLLFHFGRSVQLLLSQSPYRDISIPWSPFYASDWDAADMFPTFLQMFVTKPNLLATISSPHQITKQSLTEEHANSVALTISRASLWETYRTLFWSDFDLSIYEMEDRKQKFWLDMYKQMYEEYFPFKRAKNDYQPCSFTPIFALQPHMSMYYRKLWAEMLALDIHETFDEEDN--EVQTGERLKTTILNRGSGDVAKELFKRFQGRNPSVGAI 750          
BLAST of Thimet oligopeptidase vs. Ensembl Fly
Match: CG7791 (gene:FBgn0033038 transcript:FBtr0086057)

HSP 1 Score: 151.369 bits (381), Expect = 7.533e-38
Identity = 155/628 (24.68%), Postives = 267/628 (42.52%), Query Frame = 2
Query:  242 IAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIK-----DGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAIL-------PETRRQMEFAFN-----SRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVE---GEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIH---TKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGR 2056
            I + L+D   K A  +  + +    HP   +  A+ +A   +  +   L+  K ++     + +  D KLP      +D+ +      D + CG+HL E  R  V  ++                 + IL+     + G  +  +  L +S+  E+ R       +YFP     ++        E  +  E A+      S+ +E+    L        + A+  GF T+A   L     ++ +VV EF+ EL EKL    + + +  LM + +  E  K D   R + WD  Y+ N    QLF  +  +   YF +     G+  +   L G++ +  +   GE WH+ +    V    +  LLGY + D Y R GK        +Q GG  M D      Q+ VV ++    +     P+LL+   +   FHE GH MH++  +T+  ++T      DF E PS ++E +      L+  + H++T EP+ +++L  L  S+    A     Q+  ++ DQ  H    +      +  +SV   Y  +P  D T     F H+  GY A+YY YL S+  A+ ++ + F+     N + G  YR  IL  G +  + +L+ +FL R
Sbjct:   89 IFDELSDSLCKVADLAEFVRI---AHPQSRYTQAAEQACISICGMVESLNTHKPIYKALSHVVDHGD-KLPTSE---VDRHVSRLFLFDFEQCGIHLPEEERMRVVRLN-----------------DYILQLGQKFMSGAVQPSV--LPRSQVPESFR-------NYFPTSGENVIITGLCTNAENVQMREAAYRLYLQPSKSQEDLLRDLLLCRH---ELARSCGFDTYAHRALKGSTMEKPEVVREFIDELSEKLRPRADCDFA--LMSQMKRREGGKAD--ARAEVWDTPYYTNQLRRQLFEEHANEFLPYFSLGGCMEGLDNLLHALYGIRLQNTDLKPGEAWHNDIYKLAVVHERE-GLLGYIYCDFYERVGKPNQDCHFTIQ-GGKRMPDGS---YQLPVVVVMLGLAQPRWSGPTLLSPARLDNLFHEMGHAMHSMLARTEHQHVTGTRCSTDFAEVPSVLMEYFAGDPRVLRTFARHFQTHEPISEDMLRRLCASKNLFAASETQLQVFYSALDQEYHGASARHGQSSTDTLRSVQDHYYGLPYVDNTAWQLRFSHLV-GYGAKYYAYLVSKTIASWIWQTYFEANP-FNRQAGEKYRAEILAHGGAVPSRKLVANFLQR 669          
BLAST of Thimet oligopeptidase vs. Ensembl Fly
Match: CG11771 (gene:FBgn0039252 transcript:FBtr0084748)

HSP 1 Score: 134.035 bits (336), Expect = 3.417e-32
Identity = 129/560 (23.04%), Postives = 254/560 (45.36%), Query Frame = 2
Query:  491 DGKLCGLHLDESVRKEVESISKELSRLKIDFEKN-----------LSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKE--------ENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEM-CERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKF-EKVEGEFWHHSVELFGVKDA---NDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFT--KSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSF-DVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQ-ICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHM-AGGYDAQYYGYLWSEVFAADMFISRFQKEGLLN-AKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFL 2080
            +GKL GL LD+  +  ++ +   L R + +F+             +++ N + +F    LE  +          +      K++L+       +KH   PE  ++      S  K         EN   ++ +  LR ++A LLG+ + AD  +  +M      + +   +L +     ++ E+ +   F ++  CE        +++A+D+ Y+          +  +KLR++FP+ +V  G+F + E+L G+K  E+   E WH +V+ + V DA   N ++ +G F++D Y ++ K+G     ++ I   N      P+      A++ NF+  +S + KP LL +D++   F  FG  +  +  Q  +  L    ++E D  +    ++ N+      ++ +SGH+ +G    +  L+  +R     +A +N  Q + LA  D  +H +++   +EV + +   Y  +P+      P +   + AG + A  + +L+S + AAD+  S  ++    N A  G  Y++  L  G S    E+ + F GR P+ +A L
Sbjct:  178 EGKLNGLTLDKDKQDGLKELLTHLGRERANFKNKVNMAVHSFGQIITDFNLVRDFPPSLLEATARD------PGQPMTGPWKITLQPQVVDGFLKHC--PERMQRWNVWRASVLKASSQQEKSLENSTHIEKIRGLRKRQANLLGYESFADMSMQTKMVGSVDNLKQIFAKLLKFAGPAQSVELEKLQGFAQDSGCEY-------KLEAYDVAYWRRKQLAAEHGLQDQKLREFFPLPRVLSGLFALSEKLFGIKIVEQPNAEVWHPAVKFYDVFDADSVNSSTPVGGFYVDCYSKEHKFGRNNGWMVGIRNSNKSAGLTPL-----CALIFNFSEPQSPDAKPPLLGYDDLQMLFKTFGSGLQHLLTQAGYSDLAGLSNIEWDASQVSGHVMSNFLDDPTVIRSLSGHFSSG-EPLEAELSQKMRLLKTQLAGYNLCQDLYLADLDVELH-RSNAFWLEVVRKLWPVYQCMPLDKKDAHPCSLTDIFAGDWAAAQFSHLYSRLIAADISSSFAEQRSEENYAVVGRRYKQTFLSCGGSVPTAEVFRRFQGRDPSAEALL 715          
BLAST of Thimet oligopeptidase vs. Ensembl Zebrafish
Match: thop1 (thimet oligopeptidase 1 [Source:ZFIN;Acc:ZDB-GENE-040718-47])

HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0
Identity = 324/672 (48.21%), Postives = 449/672 (66.82%), Query Frame = 2
Query:   92 QFCQMNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            + C  N++      W    E+     E L  +    YD +G+    S+ ++   + LAD E+++  Q ++L   Q V   K  R ASTEADK LS+  V++SMR+DV+ + V L+E + +G L  ++ +Y+++ IK GK  GLHL +  ++E++ I K+LS L IDF K+L+E+ T L FS +EL G  E F+ SL K E+   K K++LKYPHYFP MK   +PETR+++E AFNSRCKEEN  +LK ++ LRA+K+ LLGF+TH+D+VL   MAK +K V  FL++L  KL  +  +E +  L  K++ C++  + F   + AWD RY+M   EE  ++V+  +L++YFP++ V +G+ +IY+ LL L FE+VEG   WH  V L+ VKD +   ++G F+LDL+PR+GKYGHA    LQ G    C +    RQ+ V AM+ANF+K T D PSLL HDEV T+FHEFGHVMH +C Q+DF   +   VERDFVE PSQMLENW W+ E ++ MS HYKTG P+ +ELL+ L++SR+AN  + N RQI LA  DQ +HTKT +DP E Y  +    + IP + GTNMPATFGH+AGGYDAQYYGYLWSEVF+ DMF +RF++EG+++ K G DYR  ILKPG S+DA +++K FLGR P QDAFL   GL
Sbjct:   14 RVCDDNRLR-----WDLTPEQINQLTEELIAKTKKVYDTVGALDLDSVNYENTLKALADVEVEYTVQRNMLDFPQHVSSSKDVRSASTEADKKLSEFDVEMSMREDVYQRIVALEEKLPEGSLSPEAKRYMERLIKLGKRNGLHLPKVTQEEIKKIKKKLSTLCIDFNKHLNEDTTCLHFSREELGGLPEDFLNSLEKDES--GKLKLTLKYPHYFPTMKKCFVPETRKKLEEAFNSRCKEENSAILKELVNLRAQKSSLLGFSTHSDFVLEMNMAKSSKKVSTFLEDLSHKLKPLGEKERAVILKLKEQECQKRNLPFTGELYAWDTRYYMTQVEETQYAVDQNQLKEYFPMEVVTKGLLDIYQELLNLTFEQVEGAPVWHDDVSLYCVKDRSSGLVVGQFYLDLFPREGKYGHAACFGLQPG----CLLPNGTRQMAVAAMVANFSKPTADAPSLLQHDEVETYFHEFGHVMHQLCAQSDFAMFSGTHVERDFVEAPSQMLENWVWEKEPIQRMSKHYKTGNPIPEELLDKLIKSRLANTGLFNLRQIVLAKVDQALHTKTGLDPAEEYARLCLDILGIPSSPGTNMPATFGHLAGGYDAQYYGYLWSEVFSMDMFYARFKQEGVMDPKVGLDYRNCILKPGGSEDAADMLKKFLGREPKQDAFLLSKGL 674          
BLAST of Thimet oligopeptidase vs. Ensembl Zebrafish
Match: thop1 (thimet oligopeptidase 1 [Source:ZFIN;Acc:ZDB-GENE-040718-47])

HSP 1 Score: 627.476 bits (1617), Expect = 0.000e+0
Identity = 322/658 (48.94%), Postives = 444/658 (67.48%), Query Frame = 2
Query:  134 WITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            W    E+     E L  +    YD +G+    S+ ++   + LAD E+++  Q ++L   Q V   K  R ASTEADK LS+  V++SMR+DV+ + V L+E + +G L  ++ +Y+++ IK GK  GLHL +  ++E++ I K+LS L IDF K+L+E+ T L FS +EL G  E F+ SL K E+   K K++LKYPHYFP MK   +PETR+++E AFNSRCKEEN  +LK ++ LRA+K+ LLGF+TH+D+VL   MAK +K V  FL++L  KL  +  +E +  L  K++ C++  + F   + AWD RY+M   EE  ++V+  +L++YFP++ V +G+ +IY+ LL L FE+VEG   WH  V L+ VKD +   ++G F+LDL+PR+GKYGHA    LQ G    C +    RQ+ V AM+ANF+K T D PSLL HDEV T+FHEFGHVMH +C Q+DF   +   VERDFVE PSQMLENW W+ E ++ MS HYKTG P+ +ELL+ L++SR+AN  + N RQI LA  DQ +HTKT +DP E Y  +    + IP + GTNMPATFGH+AGGYDAQYYGYLWSEVF+ DMF +RF++EG+++ K G DYR  ILKPG S+DA +++K FLGR P QDAFL   GL
Sbjct:   44 WDLTPEQINQLTEELIAKTKKVYDTVGALDLDSVNYENTLKALADVEVEYTVQRNMLDFPQHVSSSKDVRSASTEADKKLSEFDVEMSMREDVYQRIVALEEKLPEGSLSPEAKRYMERLIKLGKRNGLHLPKVTQEEIKKIKKKLSTLCIDFNKHLNEDTTCLHFSREELGGLPEDFLNSLEKDES--GKLKLTLKYPHYFPTMKKCFVPETRKKLEEAFNSRCKEENSAILKELVNLRAQKSSLLGFSTHSDFVLEMNMAKSSKKVSTFLEDLSHKLKPLGEKERAVILKLKEQECQKRNLPFTGELYAWDTRYYMTQVEETQYAVDQNQLKEYFPMEVVTKGLLDIYQELLNLTFEQVEGAPVWHDDVSLYCVKDRSSGLVVGQFYLDLFPREGKYGHAACFGLQPG----CLLPNGTRQMAVAAMVANFSKPTADAPSLLQHDEVETYFHEFGHVMHQLCAQSDFAMFSGTHVERDFVEAPSQMLENWVWEKEPIQRMSKHYKTGNPIPEELLDKLIKSRLANTGLFNLRQIVLAKVDQALHTKTGLDPAEEYARLCLDILGIPSSPGTNMPATFGHLAGGYDAQYYGYLWSEVFSMDMFYARFKQEGVMDPKVGLDYRNCILKPGGSEDAADMLKKFLGREPKQDAFLLSKGL 695          
BLAST of Thimet oligopeptidase vs. Ensembl Zebrafish
Match: nln (neurolysin (metallopeptidase M3 family) [Source:ZFIN;Acc:ZDB-GENE-041010-216])

HSP 1 Score: 588.571 bits (1516), Expect = 0.000e+0
Identity = 308/660 (46.67%), Postives = 425/660 (64.39%), Query Frame = 2
Query:  125 NFDWITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVE-GEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            N  W    EE ++R E L        D +GS     + F+   + +AD +  +A   H+L   Q V P K  R ASTEADK LSD  V++SMR DVF + + L+E     L  +S +++ + IK GK  GLHL E ++ E++SISK++S L IDF +NL+EENT+L FS ++L G +ES+   L K  T++ + KV+L YPHYFP+MK   +PETRR+ME AF+SRCK+ N  +L+ +++LRA+ A LLGF++HA+Y+L   MAK ++ V  FL EL E+L  +  +E    L  K   CER  ++F+ ++ AWDM Y+MN  E+  F+V+ +KL +YFP+  V  G+ +IY+ LLGLKF++VE    WH SV+L+ V D+   + +G F+LDL+PR+GKY HA    LQ G    C   +  R++ V AM+ANFTK T   PSLL H EV TFFHEFGH+MH +C ++ +   +   VE DFVE PSQMLENW W+ E L+ MS HYK   P+ D LL+ L+ SRVAN  + N RQI L+  DQ +HTK   D    +  + K  + IP T GTNM A+F H+AGGYD QYY YLWSEV++ D+F +RF+KEG+LN K G +YR ++L+ G S D  E++K FLGR P QDAF    GL
Sbjct:   47 NLRWDLTPEEIRHRTEKLIQRIKQANDTVGSVDIGKVCFENTLQVIADAKADYAASRHVLDFPQYVAPCKEVRFASTEADKRLSDFDVEVSMRADVFQRLLVLQEKQSCDLLPESERFLGRLIKLGKRNGLHLSEDIQDEIKSISKQISELSIDFNRNLNEENTVLLFSKEDLVGLAESYANGLEK--TEDGQYKVTLAYPHYFPLMKRCHVPETRRKMEKAFHSRCKDVNTAILEKLIELRARLANLLGFSSHANYMLEMTMAKNSENVARFLDELYERLRPVGEQERHYLLSLKDADCERRGLEFDGQLHAWDMPYYMNQVEQVKFAVDKDKLIEYFPLQVVTEGLLDIYQDLLGLKFQQVEKPHVWHDSVKLYSVLDSVTGNQIGQFYLDLHPREGKYSHAACFGLQPG----CVGPDGERRMPVAAMVANFTKPTSTWPSLLQHHEVETFFHEFGHIMHELCSRSRYADFSGTQVETDFVEVPSQMLENWVWEKEPLRRMSRHYKDDSPIPDALLDKLIASRVANTGLMNLRQIVLSKADQTLHTKDRADTAAEFAKLSKDILGIPATPGTNMTASFSHLAGGYDGQYYSYLWSEVYSMDIFFTRFKKEGILNPKVGREYRRVVLEAGGSVDGMEMLKTFLGREPCQDAFFQCKGL 700          
BLAST of Thimet oligopeptidase vs. Ensembl Zebrafish
Match: nln (neurolysin (metallopeptidase M3 family) [Source:ZFIN;Acc:ZDB-GENE-041010-216])

HSP 1 Score: 560.451 bits (1443), Expect = 0.000e+0
Identity = 300/660 (45.45%), Postives = 411/660 (62.27%), Query Frame = 2
Query:  125 NFDWITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVE-GEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            N  W    EE ++R E L        D +GS     + F+   + +AD +  +A   H+L   Q V P K  R ASTEADK LSD  V++SMR DVF + + L+E     L  +S +++ + IK GK  GLHL E ++ E++SISK++S L IDF +NL+EENT+L FS ++L G +ES+   L K+E  + + KV+L YPHYFP+MK   +PETRR+ME AF+SRCK+ N  +L+ +++LRA+ A LLGF++HA+Y+L   MAK ++ V  FL EL E+L  +  +E    L  K   CER  ++F+ ++ AWDM Y+MN                      V  G+ +IY+ LLGLKF++VE    WH SV+L+ V D+   + +G F+LDL+PR+GKY HA    LQ G    C   +  R++ V AM+ANFTK T   PSLL H EV TFFHEFGH+MH +C ++ +   +   VE DFVE PSQMLENW W+ E L+ MS HYK   P+ D LL+ L+ SRVAN  + N RQI L+  DQ +HTK   D    +  + K  + IP T GTNM A+F H+AGGYD QYY YLWSEV++ D+F +RF+KEG+LN K G +YR ++L+ G S D  E++K FLGR P QDAF    GL
Sbjct:   47 NLRWDLTPEEIRHRTEKLIQRIKQANDTVGSVDIGKVCFENTLQVIADAKADYAASRHVLDFPQYVAPCKEVRFASTEADKRLSDFDVEVSMRADVFQRLLVLQEKQSCDLLPESERFLGRLIKLGKRNGLHLSEDIQDEIKSISKQISELSIDFNRNLNEENTVLLFSKEDLVGLAESYANGLEKTE--DGQYKVTLAYPHYFPLMKRCHVPETRRKMEKAFHSRCKDVNTAILEKLIELRARLANLLGFSSHANYMLEMTMAKNSENVARFLDELYERLRPVGEQERHYLLSLKDADCERRGLEFDGQLHAWDMPYYMN--------------------QVVTEGLLDIYQDLLGLKFQQVEKPHVWHDSVKLYSVLDSVTGNQIGQFYLDLHPREGKYSHAACFGLQPG----CVGPDGERRMPVAAMVANFTKPTSTWPSLLQHHEVETFFHEFGHIMHELCSRSRYADFSGTQVETDFVEVPSQMLENWVWEKEPLRRMSRHYKDDSPIPDALLDKLIASRVANTGLMNLRQIVLSKADQTLHTKDRADTAAEFAKLSKDILGIPATPGTNMTASFSHLAGGYDGQYYSYLWSEVYSMDIFFTRFKKEGILNPKVGREYRRVVLEAGGSVDGMEMLKTFLGREPCQDAFFQCKGL 680          
BLAST of Thimet oligopeptidase vs. Ensembl Zebrafish
Match: nln (neurolysin (metallopeptidase M3 family) [Source:ZFIN;Acc:ZDB-GENE-041010-216])

HSP 1 Score: 266.159 bits (679), Expect = 4.188e-79
Identity = 150/321 (46.73%), Postives = 192/321 (59.81%), Query Frame = 2
Query: 1142 DKVRRGMFEIYERLLGLKFEKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKY---GHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            + V R + E+YERL      +  GE   H   L  +KDA+       F   L+  D  Y    HA    LQ G    C   +  R++ V AM+ANFTK T   PSLL H EV TFFHEFGH+MH +C ++ +   +   VE DFVE PSQMLENW W+ E L+ MS HYK   P+ D LL+ L+ SRVAN  + N RQI L+  DQ +HTK   D    +  + K  + IP T GTNM A+F H+AGGYD QYY YLWSEV++ D+F +RF+KEG+LN K G +YR ++L+ G S D  E++K FLGR P QDAF    GL
Sbjct:  312 ENVARFLDELYERL------RPVGEQERHY--LLSLKDADCERRGLEFDGQLHAWDMPYYMNQHAACFGLQPG----CVGPDGERRMPVAAMVANFTKPTSTWPSLLQHHEVETFFHEFGHIMHELCSRSRYADFSGTQVETDFVEVPSQMLENWVWEKEPLRRMSRHYKDDSPIPDALLDKLIASRVANTGLMNLRQIVLSKADQTLHTKDRADTAAEFAKLSKDILGIPATPGTNMTASFSHLAGGYDGQYYSYLWSEVYSMDIFFTRFKKEGILNPKVGREYRRVVLEAGGSVDGMEMLKTFLGREPCQDAFFQCKGL 620          

HSP 2 Score: 257.299 bits (656), Expect = 9.759e-76
Identity = 139/321 (43.30%), Postives = 202/321 (62.93%), Query Frame = 2
Query:  125 NFDWITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMN 1081
            N  W    EE ++R E L        D +GS     + F+   + +AD +  +A   H+L   Q V P K  R ASTEADK LSD  V++SMR DVF + + L+E     L  +S +++ + IK GK  GLHL E ++ E++SISK++S L IDF +NL+EENT+L FS ++L G +ES+   L K  T++ + KV+L YPHYFP+MK   +PETRR+ME AF+SRCK+ N  +L+ +++LRA+ A LLGF++HA+Y+L   MAK ++ V  FL EL E+L  +  +E    L  K   CER  ++F+ ++ AWDM Y+MN
Sbjct:   47 NLRWDLTPEEIRHRTEKLIQRIKQANDTVGSVDIGKVCFENTLQVIADAKADYAASRHVLDFPQYVAPCKEVRFASTEADKRLSDFDVEVSMRADVFQRLLVLQEKQSCDLLPESERFLGRLIKLGKRNGLHLSEDIQDEIKSISKQISELSIDFNRNLNEENTVLLFSKEDLVGLAESYANGLEK--TEDGQYKVTLAYPHYFPLMKRCHVPETRRKMEKAFHSRCKDVNTAILEKLIELRARLANLLGFSSHANYMLEMTMAKNSENVARFLDELYERLRPVGEQERHYLLSLKDADCERRGLEFDGQLHAWDMPYYMN 365          
BLAST of Thimet oligopeptidase vs. Ensembl Xenopus
Match: limk2 (LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-976145])

HSP 1 Score: 645.58 bits (1664), Expect = 0.000e+0
Identity = 318/641 (49.61%), Postives = 446/641 (69.58%), Query Frame = 2
Query:  200 YDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFD-GKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEGE-FWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 2110
            YD +G+    S+T++   + LAD E++++ +  +L   Q V P K  R ASTEADK LS+  V+ SMR+DV+ +   L+ +     L  ++ +++++ IK G+  GL+L    +++++SI K++S + IDF KNL+E+ T L FS +EL G  + F+ SL K+  D+ K K++LKYPHYFP+MK   +P+TR+++E AFNSRCKEEN  +L+ ++QLR +K+ LLGF THAD+ +   MAK +  V  FL+EL +KL  +  +E S  L  KK+ CE+  +DF+N+I+AWDMRY+MN  EE  +SV+   L+++FP++ V  G+  IY+ LLGL FE  +G   WH  V LF V+D     L+G F+LDL+PR+GKY HA    LQ G    C + +  RQ++V AM+ANFTK T+D PSLL HDEV T+FHEFGHVMH +C QTDF   +  +VERDFVE PSQMLENW W+ +SL+ MS HYKTG+P+ +E L  L++SR+AN  + N RQI LA  DQ++HT+  VDPV+ Y  +  + + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+L+ K G+DYR  ILKPG S DA E++++FLGR P QDAFL   GL N N+
Sbjct:   43 YDQVGNLDLSSVTYESTLKALADVEVEYSVKRSMLDFPQHVSPSKEIRAASTEADKKLSEFDVEKSMREDVYRRIEHLQTVIPCDTLQPEAKRFLERLIKMGQRNGLNLASDTQQKIKSIQKKMSNISIDFNKNLNEDITFLTFSREELGGLPDDFLNSLEKA--DDGKLKITLKYPHYFPLMKKCFIPDTRQKVETAFNSRCKEENSRILQELVQLREQKSSLLGFKTHADFAVEMNMAKNSTTVASFLEELSKKLKPLGEKERSIILQLKKKECEKRGLDFDNQINAWDMRYYMNQVEETTYSVDQNFLKEFFPMEVVTTGLLGIYQELLGLTFELEKGAAVWHEDVSLFSVRDDTTGQLIGKFYLDLHPREGKYSHAACFGLQPG----CLLADGSRQISVAAMVANFTKPTQDAPSLLQHDEVETYFHEFGHVMHQLCAQTDFVLFSGTNVERDFVEAPSQMLENWVWERKSLERMSQHYKTGKPIPEETLEKLIKSRLANTGLLNLRQIVLAKIDQVLHTQIGVDPVQEYSKLSSEILGVPATSGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFYTRFKQEGILSKKVGADYRNCILKPGGSLDATEMLRNFLGRDPKQDAFLQSKGLDNFNT 677          
BLAST of Thimet oligopeptidase vs. Ensembl Xenopus
Match: limk2 (LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-976145])

HSP 1 Score: 637.491 bits (1643), Expect = 0.000e+0
Identity = 316/641 (49.30%), Postives = 443/641 (69.11%), Query Frame = 2
Query:  200 YDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFD-GKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 2110
            YD +G+    S+T++   + LAD E++++ +  +L   Q V P K  R ASTEADK LS+  V+ SMR+DV+ +   L+ +     L  ++ +++++ IK G+  GL+L    +++++SI K++S + IDF KNL+E+ T L FS +EL G  + F+ SL K+  D+ K K++LKYPHYFP+MK   +P+TR+++E AFNSRCKEEN  +L+ ++QLR +K+ LLGF THAD+ +   MAK +  V  FL+EL +KL  +  +E S  L  KK+ CE+  +DF+N+I+AWDMRY+MN  EE  +SV+   L+++FP++ V  G+  IY+ LLGL FE  +G   WH  V LF V+D     L+G F+LDL+PR+GKY HA    LQ G    C + +  RQ++V AM+ANFTK T+D PSLL HDEV T+FHEFGHVMH +C QTDF   +  +VERDFVE PSQMLENW W+ +SL+ MS HYKTG+P+ +E L  L++SR+AN   H    I LA  DQ++HT+  VDPV+ Y  +  + + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+L+ K G+DYR  ILKPG S DA E++++FLGR P QDAFL   GL N N+
Sbjct:   36 YDQVGNLDLSSVTYESTLKALADVEVEYSVKRSMLDFPQHVSPSKEIRAASTEADKKLSEFDVEKSMREDVYRRIEHLQTVIPCDTLQPEAKRFLERLIKMGQRNGLNLASDTQQKIKSIQKKMSNISIDFNKNLNEDITFLTFSREELGGLPDDFLNSLEKA--DDGKLKITLKYPHYFPLMKKCFIPDTRQKVETAFNSRCKEENSRILQELVQLREQKSSLLGFKTHADFAVEMNMAKNSTTVASFLEELSKKLKPLGEKERSIILQLKKKECEKRGLDFDNQINAWDMRYYMNQVEETTYSVDQNFLKEFFPMEVVTTGLLGIYQELLGLTFELEKGAAVWHEDVSLFSVRDDTTGQLIGKFYLDLHPREGKYSHAACFGLQPG----CLLADGSRQISVAAMVANFTKPTQDAPSLLQHDEVETYFHEFGHVMHQLCAQTDFVLFSGTNVERDFVEAPSQMLENWVWERKSLERMSQHYKTGKPIPEETLEKLIKSRLANTVFH-LHMIVLAKIDQVLHTQIGVDPVQEYSKLSSEILGVPATSGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFYTRFKQEGILSKKVGADYRNCILKPGGSLDATEMLRNFLGRDPKQDAFLQSKGLDNFNT 669          
BLAST of Thimet oligopeptidase vs. Ensembl Xenopus
Match: limk2 (LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-976145])

HSP 1 Score: 637.106 bits (1642), Expect = 0.000e+0
Identity = 316/641 (49.30%), Postives = 443/641 (69.11%), Query Frame = 2
Query:  200 YDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFD-GKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 2110
            YD +G+    S+T++   + LAD E++++ +  +L   Q V P K  R ASTEADK LS+  V+ SMR+DV+ +   L+ +     L  ++ +++++ IK G+  GL+L    +++++SI K++S + IDF KNL+E+ T L FS +EL G  + F+ SL K+  D+ K K++LKYPHYFP+MK   +P+TR+++E AFNSRCKEEN  +L+ ++QLR +K+ LLGF THAD+ +   MAK +  V  FL+EL +KL  +  +E S  L  KK+ CE+  +DF+N+I+AWDMRY+MN  EE  +SV+   L+++FP++ V  G+  IY+ LLGL FE  +G   WH  V LF V+D     L+G F+LDL+PR+GKY HA    LQ G    C + +  RQ++V AM+ANFTK T+D PSLL HDEV T+FHEFGHVMH +C QTDF   +  +VERDFVE PSQMLENW W+ +SL+ MS HYKTG+P+ +E L  L++SR+AN   H    I LA  DQ++HT+  VDPV+ Y  +  + + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+L+ K G+DYR  ILKPG S DA E++++FLGR P QDAFL   GL N N+
Sbjct:   37 YDQVGNLDLSSVTYESTLKALADVEVEYSVKRSMLDFPQHVSPSKEIRAASTEADKKLSEFDVEKSMREDVYRRIEHLQTVIPCDTLQPEAKRFLERLIKMGQRNGLNLASDTQQKIKSIQKKMSNISIDFNKNLNEDITFLTFSREELGGLPDDFLNSLEKA--DDGKLKITLKYPHYFPLMKKCFIPDTRQKVETAFNSRCKEENSRILQELVQLREQKSSLLGFKTHADFAVEMNMAKNSTTVASFLEELSKKLKPLGEKERSIILQLKKKECEKRGLDFDNQINAWDMRYYMNQVEETTYSVDQNFLKEFFPMEVVTTGLLGIYQELLGLTFELEKGAAVWHEDVSLFSVRDDTTGQLIGKFYLDLHPREGKYSHAACFGLQPG----CLLADGSRQISVAAMVANFTKPTQDAPSLLQHDEVETYFHEFGHVMHQLCAQTDFVLFSGTNVERDFVEAPSQMLENWVWERKSLERMSQHYKTGKPIPEETLEKLIKSRLANTVFH-LHMIVLAKIDQVLHTQIGVDPVQEYSKLSSEILGVPATSGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFYTRFKQEGILSKKVGADYRNCILKPGGSLDATEMLRNFLGRDPKQDAFLQSKGLDNFNT 670          
BLAST of Thimet oligopeptidase vs. Ensembl Xenopus
Match: limk2 (LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-976145])

HSP 1 Score: 636.721 bits (1641), Expect = 0.000e+0
Identity = 316/641 (49.30%), Postives = 443/641 (69.11%), Query Frame = 2
Query:  200 YDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFD-GKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 2110
            YD +G+    S+T++   + LAD E++++ +  +L   Q V P K  R ASTEADK LS+  V+ SMR+DV+ +   L+ +     L  ++ +++++ IK G+  GL+L    +++++SI K++S + IDF KNL+E+ T L FS +EL G  + F+ SL K+  D+ K K++LKYPHYFP+MK   +P+TR+++E AFNSRCKEEN  +L+ ++QLR +K+ LLGF THAD+ +   MAK +  V  FL+EL +KL  +  +E S  L  KK+ CE+  +DF+N+I+AWDMRY+MN  EE  +SV+   L+++FP++ V  G+  IY+ LLGL FE  +G   WH  V LF V+D     L+G F+LDL+PR+GKY HA    LQ G    C + +  RQ++V AM+ANFTK T+D PSLL HDEV T+FHEFGHVMH +C QTDF   +  +VERDFVE PSQMLENW W+ +SL+ MS HYKTG+P+ +E L  L++SR+AN   H    I LA  DQ++HT+  VDPV+ Y  +  + + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+L+ K G+DYR  ILKPG S DA E++++FLGR P QDAFL   GL N N+
Sbjct:   47 YDQVGNLDLSSVTYESTLKALADVEVEYSVKRSMLDFPQHVSPSKEIRAASTEADKKLSEFDVEKSMREDVYRRIEHLQTVIPCDTLQPEAKRFLERLIKMGQRNGLNLASDTQQKIKSIQKKMSNISIDFNKNLNEDITFLTFSREELGGLPDDFLNSLEKA--DDGKLKITLKYPHYFPLMKKCFIPDTRQKVETAFNSRCKEENSRILQELVQLREQKSSLLGFKTHADFAVEMNMAKNSTTVASFLEELSKKLKPLGEKERSIILQLKKKECEKRGLDFDNQINAWDMRYYMNQVEETTYSVDQNFLKEFFPMEVVTTGLLGIYQELLGLTFELEKGAAVWHEDVSLFSVRDDTTGQLIGKFYLDLHPREGKYSHAACFGLQPG----CLLADGSRQISVAAMVANFTKPTQDAPSLLQHDEVETYFHEFGHVMHQLCAQTDFVLFSGTNVERDFVEAPSQMLENWVWERKSLERMSQHYKTGKPIPEETLEKLIKSRLANTVFH-LHMIVLAKIDQVLHTQIGVDPVQEYSKLSSEILGVPATSGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFYTRFKQEGILSKKVGADYRNCILKPGGSLDATEMLRNFLGRDPKQDAFLQSKGLDNFNT 680          
BLAST of Thimet oligopeptidase vs. Ensembl Xenopus
Match: limk2 (LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-976145])

HSP 1 Score: 636.336 bits (1640), Expect = 0.000e+0
Identity = 316/641 (49.30%), Postives = 443/641 (69.11%), Query Frame = 2
Query:  200 YDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFD-GKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 2110
            YD +G+    S+T++   + LAD E++++ +  +L   Q V P K  R ASTEADK LS+  V+ SMR+DV+ +   L+ +     L  ++ +++++ IK G+  GL+L    +++++SI K++S + IDF KNL+E+ T L FS +EL G  + F+ SL K+  D+ K K++LKYPHYFP+MK   +P+TR+++E AFNSRCKEEN  +L+ ++QLR +K+ LLGF THAD+ +   MAK +  V  FL+EL +KL  +  +E S  L  KK+ CE+  +DF+N+I+AWDMRY+MN  EE  +SV+   L+++FP++ V  G+  IY+ LLGL FE  +G   WH  V LF V+D     L+G F+LDL+PR+GKY HA    LQ G    C + +  RQ++V AM+ANFTK T+D PSLL HDEV T+FHEFGHVMH +C QTDF   +  +VERDFVE PSQMLENW W+ +SL+ MS HYKTG+P+ +E L  L++SR+AN   H    I LA  DQ++HT+  VDPV+ Y  +  + + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+L+ K G+DYR  ILKPG S DA E++++FLGR P QDAFL   GL N N+
Sbjct:   42 YDQVGNLDLSSVTYESTLKALADVEVEYSVKRSMLDFPQHVSPSKEIRAASTEADKKLSEFDVEKSMREDVYRRIEHLQTVIPCDTLQPEAKRFLERLIKMGQRNGLNLASDTQQKIKSIQKKMSNISIDFNKNLNEDITFLTFSREELGGLPDDFLNSLEKA--DDGKLKITLKYPHYFPLMKKCFIPDTRQKVETAFNSRCKEENSRILQELVQLREQKSSLLGFKTHADFAVEMNMAKNSTTVASFLEELSKKLKPLGEKERSIILQLKKKECEKRGLDFDNQINAWDMRYYMNQVEETTYSVDQNFLKEFFPMEVVTTGLLGIYQELLGLTFELEKGAAVWHEDVSLFSVRDDTTGQLIGKFYLDLHPREGKYSHAACFGLQPG----CLLADGSRQISVAAMVANFTKPTQDAPSLLQHDEVETYFHEFGHVMHQLCAQTDFVLFSGTNVERDFVEAPSQMLENWVWERKSLERMSQHYKTGKPIPEETLEKLIKSRLANTVFH-LHMIVLAKIDQVLHTQIGVDPVQEYSKLSSEILGVPATSGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFYTRFKQEGILSKKVGADYRNCILKPGGSLDATEMLRNFLGRDPKQDAFLQSKGLDNFNT 675          
BLAST of Thimet oligopeptidase vs. Ensembl Mouse
Match: Thop1 (thimet oligopeptidase 1 [Source:MGI Symbol;Acc:MGI:1354165])

HSP 1 Score: 640.573 bits (1651), Expect = 0.000e+0
Identity = 326/667 (48.88%), Postives = 437/667 (65.52%), Query Frame = 2
Query:  134 WITKVEEFKYRAENLKYEALHKYDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMK-----YIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEGEF-WHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 2110
            W    ++ +     L  +    YD +G++  + ++++   + LAD E+ +  Q ++L   Q V P K  R ASTEADK LS+  V++SMR+DV+ + V L+E    K P  S+K     Y+++ IK G+  GLHL +  ++++++I K LS L IDF KNL+E+ T L F+ +EL G  E F+ SL K+E  + K KV+LKYPHYFP++K   +PETRR +E AFN RCKEEN  +LK ++ LRA+K+ LLGF THADYVL   MAK ++ V  FL EL +KL  +  +E +  L  K+  C +  + F+ RI AWDMRY+MN  EE  + V+   L++YFP+  V RG+  IY+ LLGL F   EG   WH  V L+ V+DA     +G F+LDLYPR+GKYGHA    LQ G    C   +  RQ+ V AM+ANFTK T D PSLL HDEV T+FHEFGHVMH +C Q +F   +   VERDFVE PSQMLENW W+ E L  MS HY+TG     +LL  L++SR AN  + N RQI LA  DQ++HT+TD DP E Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+L+ K G DYR  IL+PG S+DA+ ++K FLGR P QDAFL   GL+ E S
Sbjct:   26 WDLSAQQIRALTTQLIEQTKCVYDRVGAQNFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPCKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQE----KTPKDSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLSSLEKAE--DGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSSLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPG----CLRQDGSRQLAVAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGSEAPQDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASAMLKQFLGRDPKQDAFLLSKGLQVEGS 682          
BLAST of Thimet oligopeptidase vs. Ensembl Mouse
Match: Nln (neurolysin (metallopeptidase M3 family) [Source:MGI Symbol;Acc:MGI:1923055])

HSP 1 Score: 575.474 bits (1482), Expect = 0.000e+0
Identity = 313/658 (47.57%), Postives = 424/658 (64.44%), Query Frame = 2
Query:  134 WITKVEEFKYRAENLKYEALHKYDVIGS--EKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFD-GKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKV-EGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            W    E+ + R E L  +    YD +G+   + +T++   + LAD E+K+  +  +L   Q V  D+  R ASTEADK LS   +++SMR+DVF + V L+E  D  K+  ++ +Y++K IK GK  GLHL E V+ E++S+ K +S L IDF KNL+E++T L FS  EL    + FI SL K  TDE+K KV+LKYPHYFP+MK   +PETRR+ME AF++RCKEEN  +L+ +L LRA+ AKLLG+ THAD+VL    AK    V  FL +L +KL  +   E    L  KK+ CE     ++ +I+AWD+ Y+M   EE  +SV+ E L++YFPI+ V  G+  IY+ LLGL FE+V +   W+ SV L+ VKD     +LG F+LDLYPR+GKY HA    LQ G    C + +  R ++V A++ NF++    +PSLL HDEV T+FHEFGHVMH IC QTDF   +  +VE DFVE PSQMLENW W  +SL+ +S HY+ G P+ DELL  L+ SR+ N  +   RQI L+  DQ +HT   +D    Y     + + +  T GTNMPATFGH+AGGYD QYYGYLWSEVF+ DMF S F+KEG++N + G  YR +ILKPG S D  +++++FL R PNQ AFL   GL
Sbjct:   50 WDLSPEQIRTRTEELIAQTKQVYDTVGTINLEDVTYENCLQVLADIEVKYIVERTMLDFPQHVSSDREVRAASTEADKRLSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLPEHVKNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEK--TDEDKYKVTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKEENTIILQQLLPLRAQVAKLLGYNTHADFVLELNTAKSTSHVATFLDDLSQKLKPLGEAEREFILSLKKKECEERGFAYDGKINAWDLHYYMTQTEELKYSVDQESLKEYFPIEVVTEGLLSIYQELLGLSFEQVADAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPG----CLLPDGSRMMSVAALVVNFSQPIAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDIDSLRKLSKHYRDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNASLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFRKEGIMNPEVGMKYRNLILKPGGSLDGMDMLQNFLQREPNQKAFLMSRGL 701          
BLAST of Thimet oligopeptidase vs. Ensembl Mouse
Match: Nln (neurolysin (metallopeptidase M3 family) [Source:MGI Symbol;Acc:MGI:1923055])

HSP 1 Score: 533.487 bits (1373), Expect = 0.000e+0
Identity = 292/618 (47.25%), Postives = 397/618 (64.24%), Query Frame = 2
Query:  134 WITKVEEFKYRAENLKYEALHKYDVIGS--EKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFD-GKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKV-EGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKT 1975
            W    E+ + R E L  +    YD +G+   + +T++   + LAD E+K+  +  +L   Q V  D+  R ASTEADK LS   +++SMR+DVF + V L+E  D  K+  ++ +Y++K IK GK  GLHL E V+ E++S+ K +S L IDF KNL+E++T L FS  EL    + FI SL K  TDE+K KV+LKYPHYFP+MK   +PETRR+ME AF++RCKEEN  +L+ +L LRA+ AKLLG+ THAD+VL    AK    V  FL +L +KL  +   E    L  KK+ CE     ++ +I+AWD+ Y+M   EE  +SV+ E L++YFPI+ V  G+  IY+ LLGL FE+V +   W+ SV L+ VKD     +LG F+LDLYPR+GKY HA    LQ G    C + +  R ++V A++ NF++    +PSLL HDEV T+FHEFGHVMH IC QTDF   +  +VE DFVE PSQMLENW W  +SL+ +S HY+ G P+ DELL  L+ SR+ N  +   RQI L+  DQ +HT   +D    Y     + + +  T GTNMPATFGH+AGGYD QYYGYLWSEVF+ DMF S F+KEG++N + 
Sbjct:   50 WDLSPEQIRTRTEELIAQTKQVYDTVGTINLEDVTYENCLQVLADIEVKYIVERTMLDFPQHVSSDREVRAASTEADKRLSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLPEHVKNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEK--TDEDKYKVTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKEENTIILQQLLPLRAQVAKLLGYNTHADFVLELNTAKSTSHVATFLDDLSQKLKPLGEAEREFILSLKKKECEERGFAYDGKINAWDLHYYMTQTEELKYSVDQESLKEYFPIEVVTEGLLSIYQELLGLSFEQVADAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPG----CLLPDGSRMMSVAALVVNFSQPIAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDIDSLRKLSKHYRDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNASLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFRKEGIMNPEV 661          
BLAST of Thimet oligopeptidase vs. Ensembl Mouse
Match: Mipep (mitochondrial intermediate peptidase [Source:MGI Symbol;Acc:MGI:1917728])

HSP 1 Score: 158.688 bits (400), Expect = 4.296e-40
Identity = 145/609 (23.81%), Postives = 269/609 (44.17%), Query Frame = 2
Query:  317 HPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKL---KEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDF----------EKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLK---YPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKF---EKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDV--DPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFL 2080
            HPD  FR+A+ EA + +  +   L+   +++    +L   K++ +  L A++ +  +  + D ++ G+HLDE  R+    ++ ++  L   F           K+L  E+    F+ D     S   I  L    +D+  R+ + K   YP+                   A   +C EE       +L  R   AKL+G++T +   L   +A+  + V +FL++L EKL+    ++       K ++  +     N+++  WD  Y+  V   + +++       +  +     G+  ++ +LLG+     +  +GE W + +    V   ++  LLGY + D + R  K    Q     I G  + + G    Q+ VV ++ N   ++ D P+LL    +   FHE GH MH++  +T + ++T      DF E PS ++E +      +   + HY+TG+PL   +++ L  S+    A     Q+  A+ DQI H +  +     ++     +Q+  +P    T     F H+  GY A+YY YL S   A+ ++   F ++   N   G  YR  +L  G  K+   +I+  L + P+ D F+
Sbjct:  127 HPDPAFREAAQEACRSIGTMVEKLNTNVELYQSLQRLLGDKKLME-SLDAETRRVAELFMFDFEISGIHLDEEKRRRAVDLNVKILDLSNAFLMRTNFPNKIRKSLLPEHIQHHFARDG----SHLIIDGLHAEASDDLVREAAYKIFLYPN-------------------ADQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQGTIAQTPETVMQFLEKLSEKLSERTRKDFKMMQGMKTKLNPQ-----NSKLMPWDPPYYSGVIRAERYNIEPSLYCPFLSLGACMEGLNVLFNKLLGITLYAEQTFKGEVWCNDIRKLAVVHESE-GLLGYIYCDFFQRANK--PQQDCHFTIRGGRLKEDGS--YQLPVVVLMLNLPHASRDFPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFSNDYRVVSQFAKHYQTGQPLPKAMVSRLCESKKVCTAAEMQLQVFYAALDQIYHGQHPLKKSTTDILMETQEQFYGLPYVPDTAWQLRFSHLV-GYGAKYYSYLMSRAVASMIWKECFLQDP-FNRAAGERYRREMLAHGGGKEPMLMIQGMLQKCPSIDDFV 692          
BLAST of Thimet oligopeptidase vs. Ensembl Mouse
Match: Mipep (mitochondrial intermediate peptidase [Source:MGI Symbol;Acc:MGI:1917728])

HSP 1 Score: 158.688 bits (400), Expect = 4.296e-40
Identity = 145/609 (23.81%), Postives = 269/609 (44.17%), Query Frame = 2
Query:  317 HPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKL---KEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDF----------EKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLK---YPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKF---EKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDV--DPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFL 2080
            HPD  FR+A+ EA + +  +   L+   +++    +L   K++ +  L A++ +  +  + D ++ G+HLDE  R+    ++ ++  L   F           K+L  E+    F+ D     S   I  L    +D+  R+ + K   YP+                   A   +C EE       +L  R   AKL+G++T +   L   +A+  + V +FL++L EKL+    ++       K ++  +     N+++  WD  Y+  V   + +++       +  +     G+  ++ +LLG+     +  +GE W + +    V   ++  LLGY + D + R  K    Q     I G  + + G    Q+ VV ++ N   ++ D P+LL    +   FHE GH MH++  +T + ++T      DF E PS ++E +      +   + HY+TG+PL   +++ L  S+    A     Q+  A+ DQI H +  +     ++     +Q+  +P    T     F H+  GY A+YY YL S   A+ ++   F ++   N   G  YR  +L  G  K+   +I+  L + P+ D F+
Sbjct:  127 HPDPAFREAAQEACRSIGTMVEKLNTNVELYQSLQRLLGDKKLME-SLDAETRRVAELFMFDFEISGIHLDEEKRRRAVDLNVKILDLSNAFLMRTNFPNKIRKSLLPEHIQHHFARDG----SHLIIDGLHAEASDDLVREAAYKIFLYPN-------------------ADQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQGTIAQTPETVMQFLEKLSEKLSERTRKDFKMMQGMKTKLNPQ-----NSKLMPWDPPYYSGVIRAERYNIEPSLYCPFLSLGACMEGLNVLFNKLLGITLYAEQTFKGEVWCNDIRKLAVVHESE-GLLGYIYCDFFQRANK--PQQDCHFTIRGGRLKEDGS--YQLPVVVLMLNLPHASRDFPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFSNDYRVVSQFAKHYQTGQPLPKAMVSRLCESKKVCTAAEMQLQVFYAALDQIYHGQHPLKKSTTDILMETQEQFYGLPYVPDTAWQLRFSHLV-GYGAKYYSYLMSRAVASMIWKECFLQDP-FNRAAGERYRREMLAHGGGKEPMLMIQGMLQKCPSIDDFV 692          
BLAST of Thimet oligopeptidase vs. UniProt/SwissProt
Match: sp|P52888|THOP1_HUMAN (Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2)

HSP 1 Score: 643.654 bits (1659), Expect = 0.000e+0
Identity = 322/662 (48.64%), Postives = 436/662 (65.86%), Query Frame = 2
Query:  125 NFDWITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLR 2098
            +  W    ++ + R   L  +    YD +G+++   ++++   + LAD E+ +  Q ++L   Q V P K  R ASTEADK LS+  V++SMR+DV+ + V L+E +    L  ++ +Y+++ IK G+  GLHL    ++ ++ I K+LS L IDF KNL+E+ T L F++ EL G  E F+ SL K E  + K KV+LKYPHYFP++K   +PETRR++E AFN RCKEEN  +LK ++ LRA+K++LLGF THADYVL   MAK ++ V  FL EL +KL  +  +E +  L  K+  CER  + F+ RI AWDMRY+MN  EE  + V+   L++YFP+  V  G+  IY+ LLGL F   EG   WH  V L+  +DA    ++G F+LDLYPR+GKYGHA    LQ G    C   +  RQ+ + AM+ANFTK T D PSLL HDEV T+FHEFGHVMH +C Q +F   +   VERDFVE PSQMLENW W+ E L  MS HY+TG  +  ELL  L+ SR AN  + N RQI LA  DQ +HT+TD DP E Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+LN+K G DYR  IL+PG S+DA+ +++ FLGR P QDAFL   GL+
Sbjct:   23 DLRWDLSAQQIEERTRELIEQTKRVYDQVGTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKME--DGKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPG----CLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQ 678          
BLAST of Thimet oligopeptidase vs. UniProt/SwissProt
Match: sp|Q8C1A5|THOP1_MOUSE (Thimet oligopeptidase OS=Mus musculus OX=10090 GN=Thop1 PE=1 SV=1)

HSP 1 Score: 640.188 bits (1650), Expect = 0.000e+0
Identity = 323/663 (48.72%), Postives = 436/663 (65.76%), Query Frame = 2
Query:  134 WITKVEEFKYRAENLKYEALHKYDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEGEF-WHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 2110
            W    ++ +     L  +    YD +G++  + ++++   + LAD E+ +  Q ++L   Q V P K  R ASTEADK LS+  V++SMR+DV+ + V L+E      L  ++ +Y+++ IK G+  GLHL +  ++++++I K LS L IDF KNL+E+ T L F+ +EL G  E F+ SL K+E  + K KV+LKYPHYFP++K   +PETRR +E AFN RCKEEN  +LK ++ LRA+K+ LLGF THADYVL   MAK ++ V  FL EL +KL  +  +E +  L  K+  C +  + F+ RI AWDMRY+MN  EE  + V+   L++YFP+  V RG+  IY+ LLGL F   EG   WH  V L+ V+DA     +G F+LDLYPR+GKYGHA    LQ G    C   +  RQ+ V AM+ANFTK T D PSLL HDEV T+FHEFGHVMH +C Q +F   +   VERDFVE PSQMLENW W+ E L  MS HY+TG     +LL  L++SR AN  + N RQI LA  DQ++HT+TD DP E Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+L+ K G DYR  IL+PG S+DA+ ++K FLGR P QDAFL   GL+ E S
Sbjct:   26 WDLSAQQIRALTTQLIEQTKCVYDRVGAQNFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPCKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKTPKNSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLSSLEKAE--DGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSSLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPG----CLRQDGSRQLAVAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGSEAPQDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASAMLKQFLGRDPKQDAFLLSKGLQVEGS 682          
BLAST of Thimet oligopeptidase vs. UniProt/SwissProt
Match: sp|P24155|THOP1_RAT (Thimet oligopeptidase OS=Rattus norvegicus OX=10116 GN=Thop1 PE=1 SV=4)

HSP 1 Score: 639.032 bits (1647), Expect = 0.000e+0
Identity = 323/662 (48.79%), Postives = 438/662 (66.16%), Query Frame = 2
Query:  134 WITKVEEFKYRAENLKYEALHKYDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEGEF-WHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNEN 2107
            W    ++ +     L  +    YD +G++  + ++++   + LAD E+ +  Q ++L   Q V P+K  R ASTEADK LS+  V++SMR+DV+ + V L+E I    L  ++ +Y+++ IK G+  GLHL +  ++++++I K LS L IDF KNL+E+ T L F+ +EL G  E F+ SL K  T++ K KV+LKYPHYFP++K   +PETRR +E AFN RCKEEN  +LK ++ LRA+K+ LLGF THADYVL   MAK ++ V  FL EL  KL  +  +E +  L  K+  C +  + F+ RI AWDMRY+MN  EE  + V+   L++YFP+  V RG+  IY+ LLGL F   EG   WH  V L+ V+DA     +G F+LDLYPR+GKYGHA    LQ G    C   +  RQ+ + AM+ANFTK T D PSLL HDEV T+FHEFGHVMH +C Q +F   +   VERDFVE PSQMLENW W+ E L  MS HY+TG    ++LL  L++SR AN  + N RQI LA  DQ++HT+TDVDP E Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ DMF +RF++EG+L+ K G DYR  IL+PG S+DA+ ++K FLGR P QDAFL   GL+ E 
Sbjct:   26 WDLSAQQIRALTTQLIEQTKCVYDRVGAQDFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPNKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKIPKDSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLNSLEK--TEDGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSNLLGFRTHADYVLEMNMAKTSQTVATFLDELARKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPG----CLRQDGSRQLAIAAMVANFTKPTPDVPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGGEAPEDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDVDPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASTMLKQFLGRDPKQDAFLLSKGLQVEG 681          
BLAST of Thimet oligopeptidase vs. UniProt/SwissProt
Match: sp|Q1JPJ8|THOP1_BOVIN (Thimet oligopeptidase OS=Bos taurus OX=9913 GN=THOP1 PE=2 SV=3)

HSP 1 Score: 635.95 bits (1639), Expect = 0.000e+0
Identity = 323/640 (50.47%), Postives = 442/640 (69.06%), Query Frame = 2
Query:  200 YDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEGE-FWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNEN 2107
            YD +G++  + ++++   + LAD E+ +  Q ++L   Q V P K  R ASTEADK LS+  V++SMR+DV+ + V L+E +    L  ++ +Y+++ IK G+  GLHL E  +++++SI K+LS L IDF KNL+E+ T L F+ +EL G  E F+ SL K  T++ K KV+LKYPHYFP++K   +PETRR++E AFN RCKEEN  +L+ +++LRA+K++LLGF+THADYVL   MAK ++VV  FL EL +KL  +  +E +  L  K+  CE+  + F+ RI+AWDMRY+MN  EE  + V+   L++YFP+  V RG+  IY+ LLGL F+  EG   WH  V L+ V+DA    L+G F+LDLYPR+GKYGHA    LQ G    C   +  RQ+ + AM+ANFTK T D PSLL HDEV T+FHEFGHVMH +C Q +F   +   VERDFVE PSQMLENW W++E L  MS HY+TG  +  ELL+ L++SR AN  + N RQI LA  DQ +HT+T  DP + Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ADMF +RF++EG+L+ K G DYR  IL+PG S+DA+ ++K FLGR P QDAFL   GL+ E 
Sbjct:   48 YDCVGAQEPQDVSYENTLKALADVEVSYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMRQDVYQRIVWLQEKVQKDSLRPEASRYLERLIKLGRRNGLHLPEETQEKIKSIKKKLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLNSLEK--TEDEKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILRELVRLRAQKSRLLGFSTHADYVLEMNMAKTSQVVATFLDELAQKLKPLGEQERAVILELKRAECEQRGLAFDGRINAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLGIYQELLGLSFQLEEGAAVWHEDVALYAVRDAASGKLIGKFYLDLYPREGKYGHAACFGLQPG----CLRKDGSRQIAIAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEAEPLLRMSQHYRTGSSIPQELLDKLIKSRQANTGLFNLRQIVLAKVDQALHTQTAADPAKEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSADMFHTRFKQEGVLSGKVGMDYRSCILRPGGSEDASVMLKLFLGRDPKQDAFLLSKGLQVEG 681          
BLAST of Thimet oligopeptidase vs. UniProt/SwissProt
Match: sp|P47788|THOP1_PIG (Thimet oligopeptidase OS=Sus scrofa OX=9823 GN=THOP1 PE=2 SV=2)

HSP 1 Score: 630.558 bits (1625), Expect = 0.000e+0
Identity = 322/640 (50.31%), Postives = 438/640 (68.44%), Query Frame = 2
Query:  200 YDVIGSE--KSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEGE-FWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNEN 2107
            YD +G++  + ++++   + LAD E+ +  Q ++L   Q V P K  R ASTEADK LS+  V++SMR+DV+ + V L+E +    L  ++ +Y+++ IK G+  GLHL +  +++++SI K+LS L IDF KNL+E+ T L  + +EL G  E F+ SL K  T++ K KV+LKYPHYFP++K   +PETRR++E AFN RCKEEN  +L+ +++LRA+K+ LLGF+THADYVL   MAK ++VV  FL EL +KL  +  +E +  L  KK  C +  +DF+ RI+AWDMRY+MN  EE  + V+   L++YFP+  V RG+  IY+ LLGL F   EG   WH  V L+ V+DA    ++G F+LDLYPR+GKYGHA    LQ G    C   +  RQ+ + AM+ANFTK T D PSLL HDEV T+FHEFGHVMH +C Q +F   +   VERDFVE PSQMLENW W++E L  MS HY+TG  +  ELL  L++SR AN  + N RQI LA  DQ +HT+T  DP E Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEV++ADMF +RF++EG+L+ K G DYR  IL+PG S+DA+ ++K FLGR P QDAFL   GL+ E 
Sbjct:   48 YDRVGTQELQDVSYENTLKALADVEVSYTVQRNILDFPQHVSPCKDIRTASTEADKKLSEFDVEMSMRQDVYQRIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPKETQEKIKSIKKKLSLLCIDFNKNLNEDTTFLPVTREELGGLPEDFLNSLEK--TEDEKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILRELVRLRAQKSSLLGFSTHADYVLEMNMAKTSQVVATFLDELAQKLKPLGEQERAVILELKKAECTKRGLDFDGRINAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLGIYQELLGLTFHLEEGAAVWHEDVMLYSVRDAASGKVIGKFYLDLYPREGKYGHAACFGLQPG----CLRQDGSRQIAIAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEAEPLLRMSQHYRTGSAIPQELLEKLIKSRQANTGLFNLRQIVLAKVDQALHTQTAADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSADMFHTRFKQEGILSGKVGMDYRSCILRPGGSEDASVMLKLFLGRDPKQDAFLLSKGLQVEG 681          
BLAST of Thimet oligopeptidase vs. TrEMBL
Match: A0A2C9MAN7 (Peptidase_M3 domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106064971 PE=3 SV=1)

HSP 1 Score: 669.463 bits (1726), Expect = 0.000e+0
Identity = 339/664 (51.05%), Postives = 454/664 (68.37%), Query Frame = 2
Query:  119 GINFDWITKVEEFKYRAENLKYEALHKYDVIG--SEKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKL--KEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            GI   W  K E+    AE L       YD +G  +E  +T+  + ++ AD +  +A + + +   Q V PDK  RDAS  ADK +SD  V+LSMR+DVF+ FV L  KE F    P ++ +++++ IK+GK  GLHLD+S+++++++I K +S L IDF KNL+EENT+LEF+ +EL G  + F+ SL K E    + KVSLKYPHYFP +K A  PETRR+ME AFNSRC +EN P+L+ +++LR +KA LLG+ THA ++L  RMAK  + V EFL  L EKL  +K EEI  +L +KKE CE+   +F+ +I+ WD+RY+M + EE+ ++V+ +KL++YF +  V +G+ EIY+ LLGL F ++E  + WH  V LF V D   + LLGYF+LDL+PR+GKYGHA    LQ G    C   +  RQV V AM+ANFTK T D+PSLL HDEV T+FHEFGHVMH IC Q DF   +   VERDFVE PSQMLENW W+ E L  MS HYK G P+ D+LL  L  SR AN  V N RQI L +FDQ IHT+ + D  ++Y  V ++Y+ I  T GTNM ATFGH+ GGYDAQYYGYLWSEVF  DMF+SRF+KEG++++K G++YR+ IL+PG S DA +++++FLGR P QDAFL   GL
Sbjct:    5 GIRLSWHVKKEQIDADAEQLMERLKQVYDSMGALTEDQVTYDNVVKSSADSDCWYAVERNNIDFLQHVSPDKDLRDASVAADKRMSDFDVELSMRQDVFESFVALEKKEEFKTFKP-EARRFVERIIKNGKRNGLHLDKSIQEKIKAIKKRMSDLSIDFSKNLNEENTVLEFTEEELAGLPDDFLKSLEKCEN--GQLKVSLKYPHYFPCVKKARNPETRRKMETAFNSRCLKENTPILEELIKLRNEKANLLGYKTHAQFILEMRMAKTPENVQEFLTSLAEKLKPLKEEEIKLFLSYKKEECEKFGFNFDGQINNWDLRYYMTMAEEKKYTVDQQKLKEYFSMSVVTKGLLEIYQELLGLTFTQIETTDVWHEDVTLFSVVDKVTSELLGYFYLDLHPREGKYGHAACFGLQPG----CIGPDGKRQVAVAAMVANFTKPTADQPSLLTHDEVETYFHEFGHVMHQICAQADFALFSGTHVERDFVEAPSQMLENWVWEKEPLTRMSAHYKDGSPIPDDLLEKLTLSRQANAGVFNLRQITLGTFDQRIHTRAEADTAKIYAEVCEEYLGIQATPGTNMAATFGHLGGGYDAQYYGYLWSEVFCMDMFMSRFKKEGIMSSKVGAEYRKYILQPGGSIDAADMLRNFLGREPKQDAFLESKGL 661          
BLAST of Thimet oligopeptidase vs. TrEMBL
Match: A0A2C9MAN0 (Peptidase_M3 domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106064971 PE=3 SV=1)

HSP 1 Score: 667.537 bits (1721), Expect = 0.000e+0
Identity = 339/664 (51.05%), Postives = 454/664 (68.37%), Query Frame = 2
Query:  119 GINFDWITKVEEFKYRAENLKYEALHKYDVIG--SEKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKL--KEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            GI   W  K E+    AE L       YD +G  +E  +T+  + ++ AD +  +A + + +   Q V PDK  RDAS  ADK +SD  V+LSMR+DVF+ FV L  KE F    P ++ +++++ IK+GK  GLHLD+S+++++++I K +S L IDF KNL+EENT+LEF+ +EL G  + F+ SL K E    + KVSLKYPHYFP +K A  PETRR+ME AFNSRC +EN P+L+ +++LR +KA LLG+ THA ++L  RMAK  + V EFL  L EKL  +K EEI  +L +KKE CE+   +F+ +I+ WD+RY+M + EE+ ++V+ +KL++YF +  V +G+ EIY+ LLGL F ++E  + WH  V LF V D   + LLGYF+LDL+PR+GKYGHA    LQ G    C   +  RQV V AM+ANFTK T D+PSLL HDEV T+FHEFGHVMH IC Q DF   +   VERDFVE PSQMLENW W+ E L  MS HYK G P+ D+LL  L  SR AN  V N RQI L +FDQ IHT+ + D  ++Y  V ++Y+ I  T GTNM ATFGH+ GGYDAQYYGYLWSEVF  DMF+SRF+KEG++++K G++YR+ IL+PG S DA +++++FLGR P QDAFL   GL
Sbjct:  123 GIRLSWHVKKEQIDADAEQLMERLKQVYDSMGALTEDQVTYDNVVKSSADSDCWYAVERNNIDFLQHVSPDKDLRDASVAADKRMSDFDVELSMRQDVFESFVALEKKEEFKTFKP-EARRFVERIIKNGKRNGLHLDKSIQEKIKAIKKRMSDLSIDFSKNLNEENTVLEFTEEELAGLPDDFLKSLEKCEN--GQLKVSLKYPHYFPCVKKARNPETRRKMETAFNSRCLKENTPILEELIKLRNEKANLLGYKTHAQFILEMRMAKTPENVQEFLTSLAEKLKPLKEEEIKLFLSYKKEECEKFGFNFDGQINNWDLRYYMTMAEEKKYTVDQQKLKEYFSMSVVTKGLLEIYQELLGLTFTQIETTDVWHEDVTLFSVVDKVTSELLGYFYLDLHPREGKYGHAACFGLQPG----CIGPDGKRQVAVAAMVANFTKPTADQPSLLTHDEVETYFHEFGHVMHQICAQADFALFSGTHVERDFVEAPSQMLENWVWEKEPLTRMSAHYKDGSPIPDDLLEKLTLSRQANAGVFNLRQITLGTFDQRIHTRAEADTAKIYAEVCEEYLGIQATPGTNMAATFGHLGGGYDAQYYGYLWSEVFCMDMFMSRFKKEGIMSSKVGAEYRKYILQPGGSIDAADMLRNFLGREPKQDAFLESKGL 779          
BLAST of Thimet oligopeptidase vs. TrEMBL
Match: A0A210PNW1 (Thimet oligopeptidase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT08803 PE=3 SV=1)

HSP 1 Score: 663.3 bits (1710), Expect = 0.000e+0
Identity = 330/672 (49.11%), Postives = 452/672 (67.26%), Query Frame = 2
Query:  104 MNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGS--EKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 2110
            M    G    W    E  + +A++L  ++   YD +GS  + S+T+  + ++LAD + ++A   + L   Q V P+K  RDAS  ADK LSD  V++SMRKDVFD  V  +E     L  ++ +++++ IK GK  GLHL +  + +++ I K +S L IDF KN +EENT+LEF+ +EL G +E F+ SL K  TD+ K KV+LKYPHYFP MK A  P TR +ME AFNSRCK+EN  +L+ ++ LR +KA+LLG+ THA +VL  RMAK A+ V  FL++L  KL  +K EE   +L +KKE CE+    F+N I  WD++Y+M + EE+ ++V+  KL++YFP+  V  G+ +IY+ LL L F+K++G   WH  + ++ V   +  +LLGYF+LDL+PR+GKYGHA    LQ G    C   +  RQVTV AM+ANFTK T+DKPSLL HDEV T+FHEFGHVMH IC QTDF   +  +VERDFVE PSQMLENWCW+   L  MS HYK G  + +ELL  LL+SR+AN  + N RQI L +FDQ IHT+ + D    +  + K  + I +T GTNMPA+FGH+AGGYDAQYYGYLWSEVF  DMF SRF+KEG+++ K G DY++ IL+PG S DA +++++FLGR P Q+AFL   GL+  ++
Sbjct:   42 MTAYAGHKLTWDLTPERIETQAKSLIEKSKAVYDTVGSLNKDSVTYDNVVKSLADNDCEYAVLRNNLDFMQHVSPNKELRDASVAADKKLSDFDVEMSMRKDVFDSIVDFQEKLSDGLTPEAARFVERMIKHGKRNGLHLPKETQDKIKKIKKRMSELSIDFSKNCNEENTVLEFTEEELAGVTEDFVKSLDK--TDDGKLKVTLKYPHYFPCMKKARNPATREKMEIAFNSRCKKENTSILEELVHLRHEKAQLLGYPTHAAFVLDMRMAKSAESVASFLKDLASKLQKLKAEETKLFLEYKKEECEKYGYQFDNVIRYWDLKYYMTMSEEKKYAVDQNKLKEYFPMQVVTSGLLDIYQELLSLTFKKMDGAPAWHEDITMYSVTCNDSAALLGYFYLDLFPREGKYGHAACFGLQPG----CLQSDGKRQVTVAAMVANFTKPTDDKPSLLTHDEVETYFHEFGHVMHQICAQTDFAMFSGTNVERDFVEAPSQMLENWCWEKVPLSRMSSHYKDGSAIPEELLQKLLQSRIANAGLFNLRQILLGTFDQTIHTQAEADTAAEFAKLSKDILGIEMTPGTNMPASFGHLAGGYDAQYYGYLWSEVFCMDMFYSRFRKEGIMSPKVGGDYKKFILRPGGSIDAADMLRNFLGRDPTQEAFLISKGLQTASN 707          
BLAST of Thimet oligopeptidase vs. TrEMBL
Match: A0A1S3IKF6 (thimet oligopeptidase isoform X1 OS=Lingula unguis OX=7574 GN=LOC106165041 PE=3 SV=1)

HSP 1 Score: 660.603 bits (1703), Expect = 0.000e+0
Identity = 328/676 (48.52%), Postives = 459/676 (67.90%), Query Frame = 2
Query:   92 QFCQMNK-----IHGINFDWITKVEEFKYRAENLKYEALHKYDVIGSEKS--LTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            QFC  N+       G    W    E+   +AE L  ++   YD +G+ K   +++ ++ + LAD   ++A + +++   Q+V  DK  RDAS  ADK +S+  V+ SMR+DVF   ++ ++    +L  ++ +Y++K+IK GK  GLHL + V+ +++ I K +S L IDF K  +EENTILEF+ +EL G  + FI  L K+E  E K KVSLKYPHYFP MK A  PETR+++E AFN+RC +EN P+L+ +++LR KKA+LLGF  HA ++L  RMAK  + V  FL++L  KL  +K++E+  ++ +KKE CE+   +F+++ + WD+RY+M++ EE+ ++V+H KL++Y+P+  V +G+ EIY+ LL LKFE++   + WH  V+++ VKD+    LLGYF+LDL+PRDGK+GHA    LQ G    C  G+  RQV V AM+ANFTK T+D+PSLL HDEV TFFHEFGHVMH +C + DF   +   VERDFVE PSQMLENWCW+ E L+ MS HYK   P+ D+L+  L +SR AN  + N RQI LA+FDQ IHT+   D   ++  + ++ MNIP T GTNMPA FGH+A GYDAQYYGY+WSEVF+ DMF SRF+KEG++N K G DYR  ILKPG S D + L+K+FLGR P Q+AFL   GL
Sbjct:   40 QFCAQNQQADMAAPGNRLRWDLTAEDIPVKAEELIKKSRAVYDAVGALKPEEISYDRVIKALADNNREYAVERNMIDFIQNVSADKALRDASVAADKKISEFDVETSMREDVFKILLEFEKRHGSELEGEAKRYLEKQIKLGKRNGLHLPKDVQDKIKEIKKRMSDLSIDFNKYCNEENTILEFTAEELVGLPDDFINGLEKTE--EGKCKVSLKYPHYFPCMKKARNPETRKRLETAFNTRCMKENTPILEELVELRHKKAELLGFPNHAAFILDMRMAKTPERVETFLKDLAVKLQPLKDQEMKVFMEYKKEECEKYGYEFDDKFNMWDLRYYMSMVEERQYTVDHTKLKEYYPLHVVTKGLLEIYQELLCLKFEEIPNPKVWHEDVKMYSVKDSASGDLLGYFYLDLFPRDGKFGHAACFGLQAG----CMGGDGKRQVAVAAMVANFTKPTQDQPSLLEHDEVETFFHEFGHVMHQLCAKADFKMFSGTSVERDFVEAPSQMLENWCWEKEPLQRMSAHYKDNSPIPDDLMEKLTKSRKANAGIFNLRQIALATFDQNIHTRAKADTATLFAELTQEIMNIPSTPGTNMPAAFGHLADGYDAQYYGYMWSEVFSMDMFHSRFKKEGIMNPKVGMDYRNYILKPGGSVDGDVLLKNFLGREPTQEAFLISKGL 709          
BLAST of Thimet oligopeptidase vs. TrEMBL
Match: A0A2R2MP34 (thimet oligopeptidase isoform X2 OS=Lingula unguis OX=7574 GN=LOC106165041 PE=3 SV=1)

HSP 1 Score: 660.218 bits (1702), Expect = 0.000e+0
Identity = 329/676 (48.67%), Postives = 459/676 (67.90%), Query Frame = 2
Query:   92 QFCQMNK-----IHGINFDWITKVEEFKYRAENLKYEALHKYDVIGSEKS--LTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            QFC  N+       G    W    E+   +AE L  ++   YD +G+ K   +++ ++ + LAD   ++A + +++   Q+V  DK  RDAS  ADK +S+  V+ SMR+DVF   ++ ++    +L  ++ +Y++K+IK GK  GLHL + V+ +++ I K +S L IDF K  +EENTILEF+ +EL G  + FI  L K+E  E K KVSLKYPHYFP MK A  PETR+++E AFN+RC +EN P+L+ +++LR KKA+LLGF  HA ++L  RMAK  + V  FL++L  KL  +K++E+  ++ +KKE CE+   +F+++ + WD+RY+M++ EE+ ++V+H KL++Y+P+  V +G+ EIY+ LL LKFE++   + WH  V+++ VKD+    LLGYF+LDL+PRDGK+GHA    LQ G    C  G+  RQV V AM+ANFTK T+D+PSLL HDEV T+FHEFGHVMH IC Q DF   +   VERDFVE PSQMLENWCW+ E L+ MS HYK   P+ D+L+  L +SR AN  + N RQI LA+FDQ IHT+   D   ++  + ++ MNIP T GTNMPA FGH+A GYDAQYYGY+WSEVF+ DMF SRF+KEG++N K G DYR  ILKPG S D + L+K+FLGR P Q+AFL   GL
Sbjct:   40 QFCAQNQQADMAAPGNRLRWDLTAEDIPVKAEELIKKSRAVYDAVGALKPEEISYDRVIKALADNNREYAVERNMIDFIQNVSADKALRDASVAADKKISEFDVETSMREDVFKILLEFEKRHGSELEGEAKRYLEKQIKLGKRNGLHLPKDVQDKIKEIKKRMSDLSIDFNKYCNEENTILEFTAEELVGLPDDFINGLEKTE--EGKCKVSLKYPHYFPCMKKARNPETRKRLETAFNTRCMKENTPILEELVELRHKKAELLGFPNHAAFILDMRMAKTPERVETFLKDLAVKLQPLKDQEMKVFMEYKKEECEKYGYEFDDKFNMWDLRYYMSMVEERQYTVDHTKLKEYYPLHVVTKGLLEIYQELLCLKFEEIPNPKVWHEDVKMYSVKDSASGDLLGYFYLDLFPRDGKFGHAACFGLQAG----CMGGDGKRQVAVAAMVANFTKPTQDQPSLLEHDEVETYFHEFGHVMHDICGQADFVMFSGTSVERDFVEAPSQMLENWCWEKEPLQRMSAHYKDNSPIPDDLMEKLTKSRKANAGIFNLRQIALATFDQNIHTRAKADTATLFAELTQEIMNIPSTPGTNMPAAFGHLADGYDAQYYGYMWSEVFSMDMFHSRFKKEGIMNPKVGMDYRNYILKPGGSVDGDVLLKNFLGREPTQEAFLISKGL 709          
BLAST of Thimet oligopeptidase vs. Ensembl Cavefish
Match: thop1 (thimet oligopeptidase 1 [Source:NCBI gene;Acc:103038939])

HSP 1 Score: 628.246 bits (1619), Expect = 0.000e+0
Identity = 320/658 (48.63%), Postives = 442/658 (67.17%), Query Frame = 2
Query:  134 WITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            W    E+     + L  +    YD +GS    ++T++   + LAD E+ +  Q ++L   Q V   K  R AST+ADK LS+  V++SMR+DV+ + V L++ + D  +  +  +Y+++ IK GK  GLHL +  ++E++ I K+LS L IDF K+L+E+ T L F+ +EL G  E F+ SL K ET     K++LKYPHYFP MK   +PETRR++E AFNSRCKEEN  +LK +++LR++K  LLGF+THAD+VL   MAK +K V  FL+EL  KL  +  EE +  L  K++ C++  + F   + AWD RY+M   EE  ++V+  +L++YFP++ V RG+ +IY+ LL L F++VEG   WH  V L+ VKD     ++G F+LDL+PR+GKYGHA    LQ G    C + +  RQ+ V AM+ANF+K T D PSLL HDEV T+FHEFGHVMH +C Q DF   +   VERDFVE PSQMLENW W+ E L+ MS HYK+  P+ +ELL+ L++SR+AN  + N RQI LA  DQ +HTK+ VDP E Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEVF+ DMF +RF++EG++N K G DYR  +LKPG S+DA+E++K FLGR P Q+AFL   GL
Sbjct:   23 WDLTPEQIHQLTDELIAKTKQVYDSVGSLDLDAVTYENTLKALADVEVDYTVQRNMLDFPQHVSSSKDVRTASTDADKKLSEFDVEMSMREDVYQRIVALQDKLQDESITPEGKRYMERLIKLGKRNGLHLPKETQEEIKKIKKKLSTLCIDFNKHLNEDTTSLSFTREELGGLPEDFLNSLEKDET--GNLKLTLKYPHYFPTMKKCYVPETRRKLEEAFNSRCKEENSAILKELVELRSQKCALLGFSTHADFVLEMNMAKASKKVASFLEELARKLKPLGEEERAVILKLKEKECQKRNLPFTGELYAWDTRYYMTQVEETQYAVDQNQLKEYFPMEVVTRGLLDIYQELLNLTFQQVEGAHVWHDDVTLYSVKDRTTGKMVGQFYLDLFPREGKYGHAACFGLQPG----CLLSDGTRQMAVAAMVANFSKPTADAPSLLQHDEVETYFHEFGHVMHQLCAQADFAMFSGTHVERDFVEAPSQMLENWVWEKEPLQRMSRHYKSNNPIPEELLDKLIKSRLANTGLFNLRQIVLAKVDQALHTKSGVDPAEEYGKLCQEMLGVPATAGTNMPATFGHLAGGYDAQYYGYLWSEVFSMDMFYARFKQEGIMNPKVGLDYRNCVLKPGGSEDASEMLKKFLGREPKQEAFLLSKGL 674          
BLAST of Thimet oligopeptidase vs. Ensembl Cavefish
Match: thop1 (thimet oligopeptidase 1 [Source:NCBI gene;Acc:103038939])

HSP 1 Score: 611.298 bits (1575), Expect = 0.000e+0
Identity = 311/644 (48.29%), Postives = 432/644 (67.08%), Query Frame = 2
Query:  134 WITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKE-IFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLG 2053
            W    E+     + L  +    YD +GS    ++T++   + LAD E+ +  Q ++L   Q V   K  R AST+ADK LS+  V++SMR+DV+ + V L++ + D  +  +  +Y+++ IK GK  GLHL +  ++E++ I K+LS L IDF K+L+E+ T L F+ +EL G  E F+ SL K ET     K++LKYPHYFP MK   +PETRR++E AFNSRCKEEN  +LK +++LR++K  LLGF+THAD+VL   MAK +K V  FL+EL  KL  +  EE +  L  K++ C++  + F   + AWD RY+M   EE  ++V+  +L++YFP++ V RG+ +IY+ LL L F++VEG   WH  V L+ VKD     ++G F+LDL+PR+GKYGHA    LQ G    C + +  RQ+ V AM+ANF+K T D PSLL HDEV T+FHEFGHVMH +C Q DF   +   VERDFVE PSQMLENW W+ E L+ MS HYK+  P+ +ELL+ L++SR+AN  + N RQI LA  DQ +HTK+ VDP E Y  + ++ + +P T GTNMPATFGH+AGGYDAQYYGYLWSEVF+ DMF +RF++EG++N K G DYR  +LKPG S+DA+E++K FL 
Sbjct:   23 WDLTPEQIHQLTDELIAKTKQVYDSVGSLDLDAVTYENTLKALADVEVDYTVQRNMLDFPQHVSSSKDVRTASTDADKKLSEFDVEMSMREDVYQRIVALQDKLQDESITPEGKRYMERLIKLGKRNGLHLPKETQEEIKKIKKKLSTLCIDFNKHLNEDTTSLSFTREELGGLPEDFLNSLEKDET--GNLKLTLKYPHYFPTMKKCYVPETRRKLEEAFNSRCKEENSAILKELVELRSQKCALLGFSTHADFVLEMNMAKASKKVASFLEELARKLKPLGEEERAVILKLKEKECQKRNLPFTGELYAWDTRYYMTQVEETQYAVDQNQLKEYFPMEVVTRGLLDIYQELLNLTFQQVEGAHVWHDDVTLYSVKDRTTGKMVGQFYLDLFPREGKYGHAACFGLQPG----CLLSDGTRQMAVAAMVANFSKPTADAPSLLQHDEVETYFHEFGHVMHQLCAQADFAMFSGTHVERDFVEAPSQMLENWVWEKEPLQRMSRHYKSNNPIPEELLDKLIKSRLANTGLFNLRQIVLAKVDQALHTKSGVDPAEEYGKLCQEMLGVPATAGTNMPATFGHLAGGYDAQYYGYLWSEVFSMDMFYARFKQEGIMNPKVGLDYRNCVLKPGGSEDASEMLKKFLA 660          
BLAST of Thimet oligopeptidase vs. Ensembl Cavefish
Match: nln (neurolysin [Source:NCBI gene;Acc:103022190])

HSP 1 Score: 603.594 bits (1555), Expect = 0.000e+0
Identity = 317/660 (48.03%), Postives = 428/660 (64.85%), Query Frame = 2
Query:  125 NFDWITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            +  W    EE K+R E L       YD +GS +   +      + LAD +L +A   H+L   Q V P K  R ASTEADK LS+  V++SMR DVF + V L+E     L  +S + +++ IK G+  GLHL   V++E++++SK++S L IDF +N++EENT+L FS +EL G +ES++  L K  T++   KVSL YPHYFP+MK   +P+TRR+ME AF+SRCKE N  +L+ +++LRAK AKLLGF  HA+YVL   MAK  K V  FL EL EKL  +  +E    L  K+  C R  ++F+ +++AWD+ YFMN  E+  FSVN +KL +YFP++ V +G+  IY+ LLGL F++V+    WH SV+L+ V D+     +G F+LDL+PR+GKYGHA    LQ G    C   +  R++ V AM+ANFTK T + PSLL H EV TFFHEFGHVMH +C +T +   +   VE DFVE PSQMLENW W+ E L+ MS HYK G P+ D+LLN L+ SRVAN  + N RQI L   DQ++HTK   D    +    K+ + IP T GTNM A+F H+AGGYD QYY YLWSEV++ D+F SRF+KEG++N K G +YR +IL+ G S D  E+++ FLGR P QDAF    GL
Sbjct:   47 DLRWDLSPEEIKHRTERLIQRIKQAYDSVGSVEIGKVCADNTLQILADAKLDYAASRHVLDFPQYVSPCKEVRSASTEADKRLSEFDVEMSMRADVFQRLVALQERQPNSLSPESKRLMERWIKLGRRNGLHLSAQVQEEIKNLSKQISELSIDFNQNINEENTVLIFSPEELGGLAESYMNGLEK--TEDGCYKVSLAYPHYFPLMKRCHVPDTRRKMEKAFHSRCKEVNTEILEQLIELRAKVAKLLGFTNHANYVLEMNMAKNTKNVACFLDELLEKLKPVGVKERQYLLSLKQAECHRRGLEFDGQLNAWDLPYFMNQVEQVKFSVNKDKLLEYFPLEVVTQGLLGIYQDLLGLMFKQVQNPHVWHESVKLYTVHDSTTGEEIGQFYLDLHPREGKYGHAACFGLQPG----CLGPDGTRRIPVAAMVANFTKPTRNWPSLLQHHEVETFFHEFGHVMHELCSKTRYAEFSGTLVETDFVEVPSQMLENWVWEKEPLRRMSQHYKDGSPIPDDLLNKLITSRVANTGLMNLRQIVLGKVDQVLHTKASADTAAEFAKHCKEILGIPATAGTNMTASFSHLAGGYDGQYYSYLWSEVYSMDIFFSRFKKEGIMNPKVGKEYRSVILEAGGSVDGMEMLRVFLGREPCQDAFFQCKGL 700          
BLAST of Thimet oligopeptidase vs. Ensembl Cavefish
Match: mipep (mitochondrial intermediate peptidase [Source:NCBI gene;Acc:103023218])

HSP 1 Score: 170.244 bits (430), Expect = 3.984e-44
Identity = 165/647 (25.50%), Postives = 277/647 (42.81%), Query Frame = 2
Query:  212 GSEKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDAS--------TEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTI----LEFSIDELEGCSESFI--GSLAKSETDENKRKVSLK---YPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDA---WDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKF---EKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDV-DPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFL 2080
            G+    TF K++++L          + L    +  HPD  +R+A+        T  +K+ +++++  S+ KD+ D     KE+   KL  ++ +  +  + D ++ G+HLD+  RKE  +++ +L  L   F       N I    L   I +      S+I  G L     D+  R+++ +   YP+                          EE    L+ +L  R K AKL+G+ + A   L   MAK    V  FLQ L +KL     ++         EM + +K  FN R  A   WD  Y   V   + F++       YF +     G+  ++ +L G+     +   GE W+  V    V    +  L+GY + D + R  K    Q     I G  + D G+   Q+ VV ++ N    T   P+LL    +   FHE GH MH++  +T + ++T      DF E PS ++E +      +   + HY+TG+PL   ++  L  S+    A     QI  A  DQ+ H K       ++   + ++Y  +P    T     F H+  GY A+YY YL S   A+ ++   F K+  LN + G  YR  +L  G  K+   +++  L + P+ + F+
Sbjct:   89 GAVTVETFDKLSDSLCRV-------ADLADFIKVAHPDPQYREAAEKTCINIGTTVEKLNTNVELCKSL-KDLLDN----KELM-AKLDPETRRVAELFMFDFEISGIHLDKKQRKEAVNLNVQLLDLNNQFLMGCHMPNRIDKKALPKHIHQHFTNEGSYIQIGGLHADAPDDLVREIAYRIFLYPN--------------------------EEMMGTLEELLSCRNKLAKLVGYESFAHRALKGTMAKNPDTVMNFLQLLTDKLKDRTEKDF--------EMMKDMKTKFNPRNPAVMPWDHPYLSGVIRAERFNIEPSLYSPYFSLGACMEGLNSLFTQLFGVSLLSEQPSAGEVWNEDVRKLAVVHETE-GLMGYIYCDFFYRPDK--PHQDCHFTIRGGRLLDDGQ--YQLPVVVLMLNLPSPTRSAPTLLTPAMMENLFHEMGHAMHSMLGRTRYQHVTGTRCATDFAEVPSILMEYFAADYRVINQFARHYQTGQPLPQSMVARLCESKKVCGAADTQLQIFYAILDQVYHGKPQSRSTTDILMDMQQKYYGLPYVPNTAWQLRFSHLI-GYGAKYYSYLMSRAVASMVWRQCFHKDP-LNRENGERYRREMLAHGGGKEPMLMVEGMLQKRPSTEDFV 681          
BLAST of Thimet oligopeptidase vs. Ensembl Cavefish
Match: mipep (mitochondrial intermediate peptidase [Source:NCBI gene;Acc:103023218])

HSP 1 Score: 165.236 bits (417), Expect = 1.451e-42
Identity = 161/628 (25.64%), Postives = 268/628 (42.68%), Query Frame = 2
Query:  230 TFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDAS--------TEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTI----LEFSIDELEGCSESFI--GSLAKSETDENKRKVSLK---YPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDA---WDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKF---EKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDV-DPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIK 2041
            TF K++++L          + L    +  HPD  +R+A+        T  +K+ +++++  S+ KD+ D     KE+   KL  ++ +  +  + D ++ G+HLD+  RKE  +++ +L  L   F       N I    L   I +      S+I  G L     D+  R+++ +   YP+                          EE    L+ +L  R K AKL+G+ + A   L   MAK    V  FLQ L +KL     ++         EM + +K  FN R  A   WD  Y   V   + F++       YF +     G+  ++ +L G+     +   GE W+  V    V    +  L+GY + D + R  K    Q     I G  + D G+   Q+ VV ++ N    T   P+LL    +   FHE GH MH++  +T + ++T      DF E PS ++E +      +   + HY+TG+PL   ++  L  S+    A     QI  A  DQ+ H K       ++   + ++Y  +P    T     F H+  GY A+YY YL S   A+ ++   F K+  LN + G  YR  +L  G  K+   +++
Sbjct:   95 TFDKLSDSLCRV-------ADLADFIKVAHPDPQYREAAEKTCINIGTTVEKLNTNVELCKSL-KDLLDN----KELM-AKLDPETRRVAELFMFDFEISGIHLDKKQRKEAVNLNVQLLDLNNQFLMGCHMPNRIDKKALPKHIHQHFTNEGSYIQIGGLHADAPDDLVREIAYRIFLYPN--------------------------EEMMGTLEELLSCRNKLAKLVGYESFAHRALKGTMAKNPDTVMNFLQLLTDKLKDRTEKDF--------EMMKDMKTKFNPRNPAVMPWDHPYLSGVIRAERFNIEPSLYSPYFSLGACMEGLNSLFTQLFGVSLLSEQPSAGEVWNEDVRKLAVVHETE-GLMGYIYCDFFYRPDK--PHQDCHFTIRGGRLLDDGQ--YQLPVVVLMLNLPSPTRSAPTLLTPAMMENLFHEMGHAMHSMLGRTRYQHVTGTRCATDFAEVPSILMEYFAADYRVINQFARHYQTGQPLPQSMVARLCESKKVCGAADTQLQIFYAILDQVYHGKPQSRSTTDILMDMQQKYYGLPYVPNTAWQLRFSHLI-GYGAKYYSYLMSRAVASMVWRQCFHKDP-LNRENGERYRREMLAHGGGKEPMLMVE 668          
BLAST of Thimet oligopeptidase vs. Ensembl Yeast
Match: PRD1 (Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000000562])

HSP 1 Score: 386.341 bits (991), Expect = 8.736e-125
Identity = 242/654 (37.00%), Postives = 370/654 (56.57%), Query Frame = 2
Query:  200 YDVIGSEKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPA---QSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSL--AKSETDENKR--KVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKF----EKVEGEFWHHSVELFGVKDAND---TSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQT-DFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIP-VTDGTNMPA---TFGH-MAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRN 2101
            YD +   +S +     E    FE +     + L+  Q V  DK  RDAS  +   L +L +DLS+R D+F QF ++ +    K  +   ++ KY++K  KD    GL LDE  R +++ I K++S   I+F KNL E+   + F+ ++LEG  +S +      KS+ D N+   KV+ KYP  FP+MK A   +TR+Q   A  ++  E    LL T L+LR + A LLG+ T+A+Y L ++MA+++  V  FL +L++KL  +  +E+      K E  ++L    +     WD RY+ N Y  + F+V+ EK+ +YFP++    GM EIYE L  LKF    +      WH  V+   V + +D    + +G+ + DL+PRDGKYGHA       G  +   + +  R   V A++ NF+KST+DKPSLL H+E+VTFFHE GH +H +  Q  +  +     V  DFVE PSQMLE W W    L  +S HYKTGE + + L+N+L++++  N A+   RQ+    FD  +HT  D+  + +  +  +   +I  +++G  +     +FGH M+  Y A YYGYLW+EVFA DM+ ++F K+  LNAK G  YR+++L  G   D N+ +K+FLGR P++DAFL  +GL+N
Sbjct:   65 YDSMSKVESPSVSNFVEPFMKFENELGPIINQLTFLQHVSSDKEIRDASVNSSMKLDELNIDLSLRHDIFLQFARVWQDVQSKADSVERETFKYVEKSYKDYIHSGLELDEGNRLKIKEIKKKISVNSINFSKNLGEQKEYITFTKEQLEGVPDSILTQFETIKSDKDSNETLYKVTFKYPDIFPVMKLASSAQTRKQAFLADQNKVPENEAILLDT-LKLRDELASLLGYDTYANYNLYDKMAEDSTTVMNFLNDLKDKLIPLGRKELQVLQDMKAEDVKKLNQGADPNYYIWDHRYYDNKYLLENFNVDLEKISEYFPLEATITGMLEIYETLFNLKFIETKDSQNKSVWHDDVKQIAVWNMDDPKSPNFVGWIYFDLHPRDGKYGHAA----NFGLSSSFMIDDTTRSYPVTALVCNFSKSTKDKPSLLKHNEIVTFFHELGHGIHDLVGQNKESRFNGPGSVPWDFVEAPSQMLEFWTWNKNELINLSSHYKTGEKIPESLINSLIKTKHVNGALFTLRQLHFGLFDMKVHTCKDLQNLSICDTWNQLRQDISLISNGGTLSKGYDSFGHIMSDSYSAGYYGYLWAEVFATDMYHTKFAKDP-LNAKNGIQYRDIVLARGGLYDINDNLKEFLGREPSKDAFLKELGLQN 712          
BLAST of Thimet oligopeptidase vs. Ensembl Yeast
Match: OCT1 (Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis [Source:SGD;Acc:S000001617])

HSP 1 Score: 147.902 bits (372), Expect = 1.895e-37
Identity = 159/633 (25.12%), Postives = 294/633 (46.45%), Query Frame = 2
Query:  293 LLSLYQSVHPDKTF----RDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDF--EKNLSEENTILEFSIDELEGCSES--FIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKN--EEISRYLMFKKEM-CERLKMDFNNRID-------AWDMRYFMNVYEE--QLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKV---EGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGH-AQVTLL---QI----GGLNMCDMGE----PIRQVTVVAMLANFTK---STEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTK---TDVDP---VEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRP 2059
            L    +S HPD  F    +D   +  + ++ L  D+S+  ++    +   E+   KL A+ +K     + D +  G++++  VR++   +S+E+S +  +F    +    N++ +    +L+    S   +  L K    +N +  +  Y  Y  ++K       R+++  A +S C ++    L  +++LRA  A L+   ++A+Y L  +MAK  K V +F+      L  M N  E+ +  L F  E+  + LK       D        WD  Y+   Y +     S N +++  YF +  V +G+ ++++++ G++ E     EGE W   V    V  + +  ++G  + DL+ R+GK  + A  T+    QI       +   +GE       Q+ V++++ NF+    +++     L   EV T FHE GH MH++  +T    ++      DFVE PS ++E++      L  +  HY TGE +  ++L   ++S           Q  +A  DQ  H +   +D+D    VE YQ++ ++ + + V D +N    FGH+  GY A YY YL+    A+ ++ + F+ +   + K G  +++ +LK G  KD  + I D L  P
Sbjct:  136 LCEFIRSTHPDDAFVRAAQDCHEQMFEFMNVLNTDVSL-CNILKSVLNNPEV-SSKLSAEELKVGKILLDDFEKSGIYMNPDVREKFIQLSQEISLVGQEFINHTDYPGSNSV-KIPCKDLDNSKVSTFLLKQLNKDVKGQNYKVPTFGYAAY-ALLKSCENEMVRKKLWTALHS-CSDKQVKRLSHLIKLRAILANLMHKTSYAEYQLEGKMAKNPKDVQDFI------LTLMNNTIEKTANELKFIAELKAKDLKKPLTTNTDEILKLVRPWDRDYYTGKYFQLNPSNSPNAKEISYYFTLGNVIQGLSDLFQQIYGIRLEPAITDEGETWSPDVRRLNVI-SEEEGIIGIIYCDLFERNGKTSNPAHFTVCCSRQIYPSETDFSTIQVGENPDGTYFQLPVISLVCNFSPILIASKKSLCFLQLSEVETLFHEMGHAMHSMLGRTHMQNISGTRCATDFVELPSILMEHFAKDIRILTKIGKHYGTGETIQADMLQRFMKSTNFLQNCETYSQAKMAMLDQSFHDEKIISDIDNFDVVENYQALERR-LKVLVDDQSNWCGRFGHLF-GYGATYYSYLFDRTIASKIWYALFEDDP-YSRKNGDKFKKHLLKWGGLKDPWKCIADVLECP 753          
BLAST of Thimet oligopeptidase vs. Ensembl Nematostella
Match: EDO48068 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJZ8])

HSP 1 Score: 629.787 bits (1623), Expect = 0.000e+0
Identity = 318/662 (48.04%), Postives = 450/662 (67.98%), Query Frame = 2
Query:  125 NFDWITKVEEFKYRAENLKYEALHKYDVIGSEKS--LTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKV-EGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTD-VDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLR 2098
            +F W    ++   + E L  +A   YD +GS K   +T++   + LA  E  +++   +L   Q +  DK  R ASTEAD+ LSD +V++SMRKD+FD  V  KE     + A++ + +DK IK G+  GLHL    + E++SI K+LS L IDF +N +EENT L F+ +EL G  + F+ SL K E  + K +VSLKYPHYFP M+ A  PETRRQ+EFAFN RC EEN  +L+ ++ LR K++ +LG+ATH+DY+   RM+K A  V +FL +L  KL+ + + E+   L  K++ C++L   ++ +I+ WDMRY+M + EE+ + ++H KL++YFP+  V +G+ +IY+ LLGL+F ++ +   WH  V+LF V+D + ++++GYF+LDL+PR+GK+ HA    LQ G    C + +  RQ++V AM ANFT+ +E++PSLL H EV TFFHEFGHVMH IC + +F   +  +VERDFVE PSQMLENWCW+ E L+ MS H+K   P+ DE+L+ L+ SR AN  V N RQI L +FDQ IHT    VD  +V+ S+  + ++IP T GTNMPA+FGH+AGGYDAQYYGYLWSEVF  DMF SRF+KEG+++ K G DYR  IL+PG S DA E++K+FLGR P+Q+AFL   GL+
Sbjct:   10 HFKWDLSPKDIAEKTEALIKKARDVYDKVGSLKPEEVTYENCLKALASSERDYSSNKSILDFPQHMSTDKDVRAASTEADRKLSDFEVEMSMRKDIFDNLVAFKENNKQPISAEAQRVLDKLIKLGRRNGLHLPVDKQNEIKSIKKKLSDLGIDFNRNCNEENTKLYFTKEELAGLPDDFVNSLDKRE--DGKLEVSLKYPHYFPCMRKASNPETRRQLEFAFNRRCMEENTKILEELVVLRKKRSDILGYATHSDYITEMRMSKSAANVSKFLSDLAIKLHPLADAELKTMLDLKEQECKQLGHPYDGKINYWDMRYYMTMVEEKNYVIDHNKLKEYFPLAVVTKGLLDIYQDLLGLRFLEIKKPHVWHEDVQLFSVEDVSTSTIIGYFYLDLFPREGKFSHAACFGLQPG----CLLDDGSRQLSVAAMEANFTRPSEERPSLLTHQEVETFFHEFGHVMHQICAKAEFALFSGTNVERDFVEAPSQMLENWCWEKEPLRRMSAHFKDKSPIPDEMLDKLIASRNANAGVFNLRQILLGTFDQEIHTSPQVVDTAKVFASLSDEILHIPATPGTNMPASFGHLAGGYDAQYYGYLWSEVFCMDMFYSRFKKEGIMSTKVGMDYRRCILEPGGSIDATEMLKNFLGREPSQEAFLVSKGLQ 665          
BLAST of Thimet oligopeptidase vs. Ensembl Nematostella
Match: EDO38082 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDW2])

HSP 1 Score: 231.876 bits (590), Expect = 2.208e-66
Identity = 167/561 (29.77%), Postives = 285/561 (50.80%), Query Frame = 2
Query:  485 IKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSI-----DELEGCSESFIGSLA----KSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRC---KEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG--EFWHHSVELFGV-KDANDTSLLGYFFLDLYPRDG-KYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTED--KPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSF-DVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHM-AGGYDAQYYGYLWSEVFAADMFISRFQKEGLLN----AKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL 2095
            ++  +  G+ L+   ++    I  +L+ L  +F  N+   ++I +FSI     ++++G   SF+   A    ++  D    K++L  P + P MK++   E R +M  AF S+    + +N  +++ +  LR +KA+LLGF  +A+  L ++MA   + VW  + EL+ K  +    EI +  MF        K  F+ ++  WD+ Y+     + LFS + E+LR YFP+++V  G+F++   +LG+  +  +G  E WH  V  F + +++  T  +  FFLD Y R   K G A +   Q  G ++    +P     V  ++ N +  + D   PSL+   EV T FHEFGH +  +     +       +VE D VE PSQ +ENW +   ++ ++SGHY+TG+PL D++   + ++R         RQ+  ++ D  +H   +   + V + +  ++  I        P  F H+ +  Y A YY Y W+E+ +AD F S FQ++GL N    AK G  +R+ IL  G S+   ++ ++F GRP   DA L L GL
Sbjct:  145 LRAARNGGVGLEREKKERFNDIRLKLAELSNNFSNNVL--DSIKQFSIIVNDKEKMQGLPPSFLQLTADDKREANADTGPWKLTLDMPCFEPFMKYSENRELRERMYKAFISKASSGQTDNSKIIEEIRDLRQEKAELLGFKDYANLSLDSKMAGTPENVWNHITELKTKSKNAAEWEIKQLQMFAD------KNGFSGKLQLWDIPYWAEKQRQHLFSYSDEQLRPYFPLERVLEGLFQLTSEILGVSVKAADGEAEVWHKDVRFFKIYENSKKTFHMASFFLDPYSRPAEKSGGAWMD--QCVGKSILLHRKP-----VAYLVCNQSPPSVDGKTPSLMTFREVETLFHEFGHGLQHMLTTVPYSDAAGINNVEWDAVEVPSQFMENWVYDRTTMDLISGHYQTGDPLPDDVFKQVCKARQYMAGSQMLRQLYFSALDMELHASRE-HWLTVLRRIADEFTVIKPHPNDRFPCGFLHIFSSSYAAGYYSYKWAELMSADAF-SAFQEKGLDNRDELAKVGKRFRDTILAKGGSRHPRDVFEEFRGRPAKPDALLALYGL 688          
BLAST of Thimet oligopeptidase vs. Ensembl Nematostella
Match: EDO43059 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZV9])

HSP 1 Score: 178.333 bits (451), Expect = 1.659e-47
Identity = 159/596 (26.68%), Postives = 263/596 (44.13%), Query Frame = 2
Query:  317 HPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIF---DGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESF--------IGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVE---GEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDV--DPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGR 2056
            HPD  FR+A+ E    +S+    L+    ++     LK  F      +  ++ K  +  + D +L G+HL+E  R++   +   +  L   F +       +L    D  +    SF        I ++    ++E  R+++ +  H  PI      PE    ++   +SR                 + A+L+ F T A   L   M K  K V  FL +  +KL     +E+      KK    + ++    +I  WD +Y+  + + Q   +N   L  YFP+     G+  I++ + G+  E  +   GE W   V+  G+    +  LLGY + D + R  K    Q +   I G  + D      Q+ +VA++ NF   +   PSLL H  V   FHE GH MH++  +T + ++T      DF E PS ++E + W S  L   + H++TG+PL +E++N L +SR    A+   RQI  +  DQI H K  +  +  ++   + K++  IP   G      F H+  GY A+YY YLWS   A+ ++   F      + + G  YR  +L  G  KD N L+   LG+
Sbjct:   88 HPDLEFREAAEETSLSVSNFVETLNTNHKLYS---VLKNAFYNEGDAMSEETRKVAELFLFDFELSGIHLEEQKRQQFVELQDAILILGSQFSQGAGL--PVLLPKGDCPDRIKNSFPVSGDNVAIDTMYLESSNEELRELAFR-SHLHPI------PEQLHCLDLLLSSR----------------NELAQLVDFPTFAHRALKGTMVKTPKNVMNFLVQASQKLKKPAEKELRILESIKKMESGKKQI----KIMPWDFQYYTGLAKTQALKLNSLSLSAYFPLGSCMEGLNFIFQNIYGITLEPEDASPGELWSTDVQKLGIVHEQE-GLLGYIYCDFFARPEKL--QQDSHFTIKGKILKD---GTYQLPIVAIICNFPPPSPSGPSLLTHGMVENLFHEMGHAMHSMLARTRYQHVTGTRCSTDFAEVPSVLMEYFAWDSRVLNKFARHFRTGQPLPEEMVNKLCQSRNMFGALEMQRQILYSIADQIYHGKHPLQKNTTDIMSDIQKEHTVIPFVSGVAWQQRFSHL-NGYGARYYSYLWSRAVASMVWHQCFHANP-FSREVGDRYRSQMLAHGGGKDPNALVAGMLGK 643          
BLAST of Thimet oligopeptidase vs. Ensembl Medaka
Match: thop1 (thimet oligopeptidase 1 [Source:NCBI gene;Acc:101157763])

HSP 1 Score: 655.596 bits (1690), Expect = 0.000e+0
Identity = 331/676 (48.96%), Postives = 460/676 (68.05%), Query Frame = 2
Query:   89 IQFCQMNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGK-LPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNE 2104
            +  C  N++      W  K E+ +  ++ L  +    YD +G+    S+TF+   + LAD E+++  Q ++L   Q V P K  R AST+ADK LS+  V++SMR+DV+ + V L++  D + L  ++ +Y+++ IK GK  GLHL +  ++E++SI K+LS L IDF KNL+E+ T L F+ DEL G  E F+ SL   E D +K KV+LKYPHYFP MK   +PETRR++E AFNSRCK+EN  +LK +++LRA K+ LLGF+THAD+VL   MAK  K V  FL+EL  +L  +  EE +  L  K++ C++  + F+  + AWD RYFM   EE  ++V+   L++YFP++ V +G+ EIY+ LLGL F+ VEG   WH  V L+ VKD     ++G F+LDL+PR+GKYGHA    LQ G    C + +  RQ++V AM+ANF+K T D PSLL HDEV T+FHEFGHVMH +C Q D+   +   VERDFVE PSQMLENW W+ E L+ MS HYKTG+P+ D+LL+ L++SR+AN  + N RQI LA  DQ +HT+T +DP E Y  + ++ + +P + GT+MPATFGH+AGGYDAQYYGYLWSEVF+ DMF +RF++EG++N K G DYR+ IL+PG S+DA+E++K FLGR P Q+AFL   GLR E
Sbjct:   13 VPVCAENRLR-----WDLKPEQIRQLSDELISDTKKVYDAVGALDLDSVTFENTLKALADVEVEYTVQRNMLDFPQHVSPCKDVRAASTDADKRLSEFDVEMSMREDVYQRVVALEKKIDAESLSLEARRYMERLIKLGKRNGLHLSKDTQEEIKSIKKKLSNLCIDFNKNLNEDTTSLGFTRDELGGLPEDFLNSL---EKDGDKLKVTLKYPHYFPTMKKCFVPETRRKLEEAFNSRCKQENSAILKELVKLRAHKSSLLGFSTHADFVLEMNMAKSGKKVSGFLEELARRLKPLGEEERAVILKLKEKECQKRGLPFDGELHAWDTRYFMTQVEETQYAVDQNLLKEYFPMEVVTQGLLEIYQDLLGLSFQLVEGASVWHPDVTLYSVKDRGSGQMVGQFYLDLHPREGKYGHAACFGLQPG----CLLHDGSRQMSVAAMVANFSKPTADAPSLLQHDEVETYFHEFGHVMHQLCAQADYAMFSGTHVERDFVEAPSQMLENWVWEKEPLQKMSKHYKTGKPIPDQLLDKLIKSRLANTGLFNLRQIVLAKVDQALHTRTGLDPAEEYGRLCQEILGVPASPGTDMPATFGHLAGGYDAQYYGYLWSEVFSMDMFYARFKQEGIMNPKVGQDYRKFILRPGGSEDASEMLKKFLGRDPKQEAFLLSKGLRVE 676          
BLAST of Thimet oligopeptidase vs. Ensembl Medaka
Match: thop1 (thimet oligopeptidase 1 [Source:NCBI gene;Acc:101157763])

HSP 1 Score: 652.899 bits (1683), Expect = 0.000e+0
Identity = 332/681 (48.75%), Postives = 460/681 (67.55%), Query Frame = 2
Query:   65 FQLFT*LAIQFCQMNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGSEK--SLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEG-EFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLR 2098
            F +F    +  C  N++      W  K E+ +  ++ L  +    YD +G+    S+TF+   + LAD E+++  Q ++L   Q V P K  R AST+ADK LS+  V++SMR+DV+ + V L++I    L  ++ +Y+++ IK GK  GLHL +   +E++SI K+LS L IDF KNL+E+ T L F+ DEL G  E F+ SL   E D +K KV+LKYPHYFP MK   +PETRR++E AFNSRCK+EN  +LK +++LRA K+ LLGF+THAD+VL   MAK  K V  FL+EL  +L  +  EE +  L  K++ C++  + F+  + AWD RYFM   EE  ++V+   L++YFP++ V +G+ EIY+ LLGL F+ VEG   WH  V L+ VKD     ++G F+LDL+PR+GKYGHA    LQ G    C + +  RQ++V AM+ANF+K T D PSLL HDEV T+FHEFGHVMH +C Q D+   +   VERDFVE PSQMLENW W+ E L+ MS HYKTG+P+ D+LL+ L++SR+AN  + N RQI LA  DQ +HT+T +DP E Y  + ++ + +P + GT+MPATFGH+AGGYDAQYYGYLWSEVF+ DMF +RF++EG++N K G DYR+ IL+PG S+DA+E++K FLGR P Q+AFL   GLR
Sbjct:   28 FGVFDPFPVPVCAENRLR-----WDLKPEQIRQLSDELISDTKKVYDAVGALDLDSVTFENTLKALADVEVEYTVQRNMLDFPQHVSPCKDVRAASTDADKRLSEFDVEMSMREDVYQRVVALEKIDAESLSLEARRYMERLIKLGKRNGLHLSKDT-QEIKSIKKKLSNLCIDFNKNLNEDTTSLGFTRDELGGLPEDFLNSL---EKDGDKLKVTLKYPHYFPTMKKCFVPETRRKLEEAFNSRCKQENSAILKELVKLRAHKSSLLGFSTHADFVLEMNMAKSGKKVSGFLEELARRLKPLGEEERAVILKLKEKECQKRGLPFDGELHAWDTRYFMTQVEETQYAVDQNLLKEYFPMEVVTQGLLEIYQDLLGLSFQLVEGASVWHPDVTLYSVKDRGSGQMVGQFYLDLHPREGKYGHAACFGLQPG----CLLHDGSRQMSVAAMVANFSKPTADAPSLLQHDEVETYFHEFGHVMHQLCAQADYAMFSGTHVERDFVEAPSQMLENWVWEKEPLQKMSKHYKTGKPIPDQLLDKLIKSRLANTGLFNLRQIVLAKVDQALHTRTGLDPAEEYGRLCQEILGVPASPGTDMPATFGHLAGGYDAQYYGYLWSEVFSMDMFYARFKQEGIMNPKVGQDYRKFILRPGGSEDASEMLKKFLGRDPKQEAFLLSKGLR 695          
BLAST of Thimet oligopeptidase vs. Ensembl Medaka
Match: nln (neurolysin [Source:NCBI gene;Acc:101172348])

HSP 1 Score: 572.392 bits (1474), Expect = 0.000e+0
Identity = 303/676 (44.82%), Postives = 425/676 (62.87%), Query Frame = 2
Query:   98 CQMNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGS--EKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVE--GEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL-RNENS 2110
            CQ  +       W    EE +   + L       YD +GS   ++++ +   + LAD  L +A+  H+L   Q V P K  R ASTEADK L D  V++SMR+DVF +   L++     L  +  +++D+ +  G+  GLHL +  ++E++  SK +S L I+F KNL+E+ T L FS  EL G ++S++  L +  T E + KV+L+YPHYFP+MK    PETRR+ME AF+SRCKE N  +L+ ++QLRAK A LLG+ +HADYVL   MAK A  V EF+    ++L  +  +E    L  KK  C    + F+ +I+AWD+ Y+MN  E+  F+VN +KL +YFP++ V  G+F IY+ LLGL F +VE  G+ WH +V+L+   D+     +G F+LDL+PR+GKYGHA    LQ G    C   +  R++ V AM+ANFTK ++  PSLL H EV T+FHEFGHVMH IC +T F   +   VE DFVE PSQMLENW W+ E L+ MS HYK G P+ DELL+ L+ SRVAN  + N RQ+ L+  DQ +H+    D  EV+  + +  + +P T GTNM A+F H+AGGYD QYY YLWSEVF+ D+F SRF+KEG++N K G +YR+++L+ G S D  E++K FL R P Q+AF    GL R+E +
Sbjct:   36 CQAARTRN-TLKWDLTPEEIRSMTDTLMVRVQKVYDEVGSLNVENVSVENTLKVLADVRLDYASSRHVLDFPQYVSPRKDVRSASTEADKKLCDFDVEISMREDVFKRITALQKKHLSHLSGEEKRFLDRLVTLGQRKGLHLPKDTQEEIKRSSKLISELSIEFNKNLNEDITSLVFSEWELGGLADSYLNGLER--TAEGRYKVTLEYPHYFPLMKRCHNPETRRKMETAFHSRCKEANTAILEQLIQLRAKVADLLGYGSHADYVLEMNMAKTASRVSEFIDAFYQRLKPVGIKERKYILALKKRECLMKGLKFDGQINAWDLPYYMNQVEQCKFAVNKDKLIEYFPLEVVTEGLFGIYQELLGLTFTQVEHGGDVWHENVKLYSACDSETGEQVGQFYLDLHPREGKYGHAACFGLQPG----CRGPDGKRRLPVAAMVANFTKPSKGWPSLLQHHEVETYFHEFGHVMHEICSKTTFSEFSGTQVETDFVEVPSQMLENWVWEKEPLRRMSRHYKDGTPIPDELLDKLIASRVANTGLMNLRQVVLSKVDQTLHSSKSADTAEVFAKIHQDILGVPATPGTNMTASFSHLAGGYDGQYYSYLWSEVFSMDIFFSRFKKEGIMNPKVGKEYRKVVLEAGGSVDGMEMLKSFLRREPQQEAFFECKGLIRSEGA 704          
BLAST of Thimet oligopeptidase vs. Ensembl Medaka
Match: nln (neurolysin [Source:NCBI gene;Acc:101172348])

HSP 1 Score: 572.392 bits (1474), Expect = 0.000e+0
Identity = 303/676 (44.82%), Postives = 425/676 (62.87%), Query Frame = 2
Query:   98 CQMNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGS--EKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVE--GEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL-RNENS 2110
            CQ  +       W    EE +   + L       YD +GS   ++++ +   + LAD  L +A+  H+L   Q V P K  R ASTEADK L D  V++SMR+DVF +   L++     L  +  +++D+ +  G+  GLHL +  ++E++  SK +S L I+F KNL+E+ T L FS  EL G ++S++  L +  T E + KV+L+YPHYFP+MK    PETRR+ME AF+SRCKE N  +L+ ++QLRAK A LLG+ +HADYVL   MAK A  V EF+    ++L  +  +E    L  KK  C    + F+ +I+AWD+ Y+MN  E+  F+VN +KL +YFP++ V  G+F IY+ LLGL F +VE  G+ WH +V+L+   D+     +G F+LDL+PR+GKYGHA    LQ G    C   +  R++ V AM+ANFTK ++  PSLL H EV T+FHEFGHVMH IC +T F   +   VE DFVE PSQMLENW W+ E L+ MS HYK G P+ DELL+ L+ SRVAN  + N RQ+ L+  DQ +H+    D  EV+  + +  + +P T GTNM A+F H+AGGYD QYY YLWSEVF+ D+F SRF+KEG++N K G +YR+++L+ G S D  E++K FL R P Q+AF    GL R+E +
Sbjct:   30 CQAARTRN-TLKWDLTPEEIRSMTDTLMVRVQKVYDEVGSLNVENVSVENTLKVLADVRLDYASSRHVLDFPQYVSPRKDVRSASTEADKKLCDFDVEISMREDVFKRITALQKKHLSHLSGEEKRFLDRLVTLGQRKGLHLPKDTQEEIKRSSKLISELSIEFNKNLNEDITSLVFSEWELGGLADSYLNGLER--TAEGRYKVTLEYPHYFPLMKRCHNPETRRKMETAFHSRCKEANTAILEQLIQLRAKVADLLGYGSHADYVLEMNMAKTASRVSEFIDAFYQRLKPVGIKERKYILALKKRECLMKGLKFDGQINAWDLPYYMNQVEQCKFAVNKDKLIEYFPLEVVTEGLFGIYQELLGLTFTQVEHGGDVWHENVKLYSACDSETGEQVGQFYLDLHPREGKYGHAACFGLQPG----CRGPDGKRRLPVAAMVANFTKPSKGWPSLLQHHEVETYFHEFGHVMHEICSKTTFSEFSGTQVETDFVEVPSQMLENWVWEKEPLRRMSRHYKDGTPIPDELLDKLIASRVANTGLMNLRQVVLSKVDQTLHSSKSADTAEVFAKIHQDILGVPATPGTNMTASFSHLAGGYDGQYYSYLWSEVFSMDIFFSRFKKEGIMNPKVGKEYRKVVLEAGGSVDGMEMLKSFLRREPQQEAFFECKGLIRSEGA 698          
BLAST of Thimet oligopeptidase vs. Ensembl Medaka
Match: nln (neurolysin [Source:NCBI gene;Acc:101172348])

HSP 1 Score: 531.946 bits (1369), Expect = 0.000e+0
Identity = 295/676 (43.64%), Postives = 400/676 (59.17%), Query Frame = 2
Query:   98 CQMNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGS--EKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVE--GEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGL-RNENS 2110
            CQ  +       W    EE +   + L       YD +GS   ++++ +   + LAD  L +A+  H+L   Q V P K  R ASTEADK L D  V++SMR+DVF +   L                                    +V S SK +S L I+F KNL+E+ T L FS  EL        G L  +E    + KV+L+YPHYFP+MK    PETRR+ME AF+SRCKE N  +L+ ++QLRAK A LLG+ +HADYVL   MAK A  V EF+    ++L  +  +E    L  KK  C    + F+ +I+AWD+ Y+MN  E+  F+VN +KL +YFP++ V  G+F IY+ LLGL F +VE  G+ WH +V+L+   D+     +G F+LDL+PR+GKYGHA    LQ G    C   +  R++ V AM+ANFTK ++  PSLL H EV T+FHEFGHVMH IC +T F   +   VE DFVE PSQMLENW W+ E L+ MS HYK G P+ DELL+ L+ SRVAN  + N RQ+ L+  DQ +H+    D  EV+  + +  + +P T GTNM A+F H+AGGYD QYY YLWSEVF+ D+F SRF+KEG++N K G +YR+++L+ G S D  E++K FL R P Q+AF    GL R+E +
Sbjct:   21 CQAARTRN-TLKWDLTPEEIRSMTDTLMVRVQKVYDEVGSLNVENVSVENTLKVLADVRLDYASSRHVLDFPQYVSPRKDVRSASTEADKKLCDFDVEISMREDVFKRITAL------------------------------------QVRSSSKLISELSIEFNKNLNEDITSLVFSEWEL--------GKLVSTE---GRYKVTLEYPHYFPLMKRCHNPETRRKMETAFHSRCKEANTAILEQLIQLRAKVADLLGYGSHADYVLEMNMAKTASRVSEFIDAFYQRLKPVGIKERKYILALKKRECLMKGLKFDGQINAWDLPYYMNQVEQCKFAVNKDKLIEYFPLEVVTEGLFGIYQELLGLTFTQVEHGGDVWHENVKLYSACDSETGEQVGQFYLDLHPREGKYGHAACFGLQPG----CRGPDGKRRLPVAAMVANFTKPSKGWPSLLQHHEVETYFHEFGHVMHEICSKTTFSEFSGTQVETDFVEVPSQMLENWVWEKEPLRRMSRHYKDGTPIPDELLDKLIASRVANTGLMNLRQVVLSKVDQTLHSSKSADTAEVFAKIHQDILGVPATPGTNMTASFSHLAGGYDGQYYSYLWSEVFSMDIFFSRFKKEGIMNPKVGKEYRKVVLEAGGSVDGMEMLKSFLRREPQQEAFFECKGLIRSEGA 644          
BLAST of Thimet oligopeptidase vs. Planmine SMEST
Match: SMESG000014736.1 (SMESG000014736.1)

HSP 1 Score: 1361.67 bits (3523), Expect = 0.000e+0
Identity = 666/669 (99.55%), Postives = 668/669 (99.85%), Query Frame = 2
Query:  104 MNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGSEKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKFEKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 2110
            MNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGSEKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIG+LAKSET ENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPI+KVRRGMFEIYERLLGLKFEKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGEPLDDELLNNLLRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS
Sbjct:    1 MNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGSEKSLTFQKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGALAKSETGENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIEKVRRGMFEIYERLLGLKFEKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLLNHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCWQSESLKMMSGHYKTGEPLDDELLNNLLRSRVANIAVHNTRQICLASFDQIIHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLGRPPNQDAFLTLMGLRNENS 669          
BLAST of Thimet oligopeptidase vs. Planmine SMEST
Match: SMESG000003984.1 (SMESG000003984.1)

HSP 1 Score: 63.1586 bits (152), Expect = 3.724e-10
Identity = 83/383 (21.67%), Postives = 151/383 (39.43%), Query Frame = 2
Query:  236 QKIAENLADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKDVFDQFVKLKEIFDGKLPAQSMKYIDKKIK-----DGKLCGLHLDESVRKEVESISKELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRKVSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGP----LLKTMLQLRAKKAKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYL--MFKKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVRRGMFEIYERLLGLKF---EKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYPRDGKYGHAQVTLL 1342
            +KI E L D        + L    + +HPD+  R  S    + +S +  +L+  +D+F     + +     LP   +  +DK++      D +  G+HL +  R                  + + E    LEFS    EG +E  +   A    +  +  + LK      +     L       E    SR   +N P    LL  +++ R   AK  GF+++A+    + + +  + V++FL  L  +L      +  R L   + + + +      N +I  WD++Y++   +E     ++E    Y  +     G+  I++   G++    E + GE WH  V    V+       LG  + D++ R  K     VTLL
Sbjct:   82 RKIIEILDDMSDSICQVADLSECMRLLHPDENVRRVSALVSQTMSKIVEELNTNQDLFGVLDNVVKTNSDVLP---LDDVDKRVATLLHVDFQTSGIHLSKENRN-----------------RYVEETQRCLEFSSLFYEG-TELAVKIRASLLPEHIQTSIGLKPDQKIEVSHPYSLANEHHLREMG--SRVFYQNNPEQERLLSNLMESRYNIAKYTGFSSYAERANVHLICETTENVYKFLNHLSSRLLPYAESDRLRILNAKYNQNLTQSDLYSGNYQIQPWDIQYYIYSLKEAAVRGSYEPYYPYLSLGNCMEGINMIFQSQFGVELEVEETIPGELWHPDVFKVSVRH-KILGHLGTVYCDMFSRPDK--SQTVTLL 438          
BLAST of Thimet oligopeptidase vs. Planmine SMEST
Match: SMESG000003983.1 (SMESG000003983.1)

HSP 1 Score: 52.7582 bits (125), Expect = 1.558e-7
Identity = 48/171 (28.07%), Postives = 78/171 (45.61%), Query Frame = 2
Query: 1586 LENWCWQSESLKMMSGHYKTGXXXXXXXXXXXXRSRVANIAVHNTRQICLASFDQIIHTK-----TDVDPVEVYQSVVKQYMNIPVTDGTNM------------PATFGHMAGGYDAQYYGYLWSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDF 2047
            +E++   S  +K  S HY+ GE L D ++  L + R    A  +   I    FDQI+H K     ++ D  EVY ++   +++  +  G+ +            P  FGH+   Y A+YY YL S      ++ + F  +   N+  G  Y+  IL+ G  K   E+I DF
Sbjct:    1 MEHFALDSRVIKEYSRHYQNGEKLPDNMIIPLSKQRYLCSAFEHQMTIVDCMFDQIVHGKDLPLSSNRDSYEVYNNI---FLDGNIVIGSKVFDRPDINCKLYRPQRFGHLI-NYGAKYYSYLMSNCIVGFLWKNGFHLDPWSNS-VGERYKNAILQHGGEKKPIEMIADF 166          
The following BLAST results are available for this feature:
BLAST of Thimet oligopeptidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
THOP10.000e+048.64thimet oligopeptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
THOP10.000e+052.09thimet oligopeptidase 1 [Source:HGNC Symbol;Acc:HG... [more]
NLN0.000e+047.26neurolysin [Source:HGNC Symbol;Acc:HGNC:16058][more]
NLN0.000e+049.09neurolysin [Source:HGNC Symbol;Acc:HGNC:16058][more]
NLN1.466e-11145.03neurolysin [Source:HGNC Symbol;Acc:HGNC:16058][more]
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BLAST of Thimet oligopeptidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Y67H2A.79.190e-1520.50pep chromosome:WBcel235:IV:13303746:13310818:1 gen... [more]
Y67H2A.72.158e-1222.40pep chromosome:WBcel235:IV:13307113:13310802:1 gen... [more]
ZK550.34.460e-1120.65pep chromosome:WBcel235:IV:17250131:17254964:1 gen... [more]
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BLAST of Thimet oligopeptidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CG77917.533e-3824.68gene:FBgn0033038 transcript:FBtr0086057[more]
CG117713.417e-3223.04gene:FBgn0039252 transcript:FBtr0084748[more]
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BLAST of Thimet oligopeptidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
thop10.000e+048.21thimet oligopeptidase 1 [Source:ZFIN;Acc:ZDB-GENE-... [more]
thop10.000e+048.94thimet oligopeptidase 1 [Source:ZFIN;Acc:ZDB-GENE-... [more]
nln0.000e+046.67neurolysin (metallopeptidase M3 family) [Source:ZF... [more]
nln0.000e+045.45neurolysin (metallopeptidase M3 family) [Source:ZF... [more]
nln4.188e-7946.73neurolysin (metallopeptidase M3 family) [Source:ZF... [more]
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BLAST of Thimet oligopeptidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
limk20.000e+049.61LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-97... [more]
limk20.000e+049.30LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-97... [more]
limk20.000e+049.30LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-97... [more]
limk20.000e+049.30LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-97... [more]
limk20.000e+049.30LIM domain kinase 2 [Source:Xenbase;Acc:XB-GENE-97... [more]
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BLAST of Thimet oligopeptidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Thop10.000e+048.88thimet oligopeptidase 1 [Source:MGI Symbol;Acc:MGI... [more]
Nln0.000e+047.57neurolysin (metallopeptidase M3 family) [Source:MG... [more]
Nln0.000e+047.25neurolysin (metallopeptidase M3 family) [Source:MG... [more]
Mipep4.296e-4023.81mitochondrial intermediate peptidase [Source:MGI S... [more]
Mipep4.296e-4023.81mitochondrial intermediate peptidase [Source:MGI S... [more]
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BLAST of Thimet oligopeptidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P52888|THOP1_HUMAN0.000e+048.64Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=T... [more]
sp|Q8C1A5|THOP1_MOUSE0.000e+048.72Thimet oligopeptidase OS=Mus musculus OX=10090 GN=... [more]
sp|P24155|THOP1_RAT0.000e+048.79Thimet oligopeptidase OS=Rattus norvegicus OX=1011... [more]
sp|Q1JPJ8|THOP1_BOVIN0.000e+050.47Thimet oligopeptidase OS=Bos taurus OX=9913 GN=THO... [more]
sp|P47788|THOP1_PIG0.000e+050.31Thimet oligopeptidase OS=Sus scrofa OX=9823 GN=THO... [more]
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BLAST of Thimet oligopeptidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2C9MAN70.000e+051.05Peptidase_M3 domain-containing protein OS=Biomphal... [more]
A0A2C9MAN00.000e+051.05Peptidase_M3 domain-containing protein OS=Biomphal... [more]
A0A210PNW10.000e+049.11Thimet oligopeptidase OS=Mizuhopecten yessoensis O... [more]
A0A1S3IKF60.000e+048.52thimet oligopeptidase isoform X1 OS=Lingula unguis... [more]
A0A2R2MP340.000e+048.67thimet oligopeptidase isoform X2 OS=Lingula unguis... [more]
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BLAST of Thimet oligopeptidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
thop10.000e+048.63thimet oligopeptidase 1 [Source:NCBI gene;Acc:1030... [more]
thop10.000e+048.29thimet oligopeptidase 1 [Source:NCBI gene;Acc:1030... [more]
nln0.000e+048.03neurolysin [Source:NCBI gene;Acc:103022190][more]
mipep3.984e-4425.50mitochondrial intermediate peptidase [Source:NCBI ... [more]
mipep1.451e-4225.64mitochondrial intermediate peptidase [Source:NCBI ... [more]
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BLAST of Thimet oligopeptidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Thimet oligopeptidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
PRD18.736e-12537.00Zinc metalloendopeptidase; found in the cytoplasm ... [more]
OCT11.895e-3725.12Mitochondrial intermediate peptidase; cleaves dest... [more]
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BLAST of Thimet oligopeptidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO480680.000e+048.04Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO380822.208e-6629.77Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO430591.659e-4726.68Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Thimet oligopeptidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
thop10.000e+048.96thimet oligopeptidase 1 [Source:NCBI gene;Acc:1011... [more]
thop10.000e+048.75thimet oligopeptidase 1 [Source:NCBI gene;Acc:1011... [more]
nln0.000e+044.82neurolysin [Source:NCBI gene;Acc:101172348][more]
nln0.000e+044.82neurolysin [Source:NCBI gene;Acc:101172348][more]
nln0.000e+043.64neurolysin [Source:NCBI gene;Acc:101172348][more]
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BLAST of Thimet oligopeptidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000014736.10.000e+099.55SMESG000014736.1[more]
SMESG000003984.13.724e-1021.67SMESG000003984.1[more]
SMESG000003983.11.558e-728.07SMESG000003983.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30016571 ID=SMED30016571|Name=Thimet oligopeptidase|organism=Schmidtea mediterranea sexual|type=transcript|length=2153bp
GTTCTTTATCAAGTCTAATTGAAATACTTAAAATTAATTAATTATTAAAT
TTTCAATTTCTAAATTTCAATTATTTACTTGATTAGCTATACAATTTTGC
CAAATGAATAAAATCCACGGTATCAATTTCGACTGGATCACAAAAGTTGA
AGAGTTTAAATATAGAGCTGAAAATCTCAAATATGAAGCCCTGCATAAGT
ATGATGTAATCGGGAGTGAAAAGTCCTTAACATTCCAAAAAATTGCTGAA
AATTTGGCGGATTTTGAATTGAAATTTGCAACTCAGTCACATTTACTAAG
TCTTTATCAATCTGTACATCCTGACAAAACATTCCGAGATGCAAGTACTG
AAGCTGATAAGATTTTGTCCGATCTGAAAGTTGATTTAAGTATGAGAAAA
GATGTGTTTGATCAATTCGTAAAATTGAAAGAAATATTCGACGGAAAACT
TCCGGCTCAGTCAATGAAATATATAGACAAAAAGATTAAAGATGGAAAAC
TTTGTGGACTACATTTGGACGAGTCCGTAAGAAAAGAGGTGGAAAGTATT
TCCAAGGAATTGAGTAGATTAAAAATTGATTTTGAAAAAAACCTTTCAGA
AGAGAATACAATCCTTGAGTTTTCAATTGACGAATTAGAGGGATGCTCGG
AATCTTTCATAGGCTCATTGGCAAAGAGTGAAACAGATGAAAATAAACGA
AAAGTTTCACTGAAATATCCCCATTATTTTCCAATTATGAAACACGCGAT
TTTACCGGAAACTCGTAGGCAAATGGAATTTGCCTTCAACAGCAGATGTA
AAGAGGAAAACGGGCCTTTATTAAAAACCATGTTGCAGTTACGAGCTAAA
AAAGCTAAATTGCTGGGGTTTGCGACCCACGCCGATTATGTGCTTAGTAA
TAGAATGGCGAAAGAAGCCAAAGTTGTCTGGGAGTTTTTGCAAGAACTGC
GAGAGAAATTGAATTCAATGAAAAATGAGGAAATCTCGAGATATTTAATG
TTTAAGAAAGAAATGTGTGAGCGATTGAAAATGGATTTCAACAACCGAAT
TGATGCGTGGGACATGCGATACTTCATGAATGTTTATGAAGAGCAACTGT
TCTCTGTGAATCACGAGAAATTGCGCGATTATTTCCCGATTGACAAAGTG
AGGAGAGGAATGTTTGAGATCTATGAGCGCTTGCTGGGATTGAAATTCGA
GAAAGTCGAAGGGGAATTTTGGCATCACAGTGTTGAATTGTTTGGTGTAA
AGGACGCCAATGATACTAGTTTATTGGGGTATTTCTTTCTGGACCTTTAT
CCCAGGGACGGGAAATACGGTCACGCTCAGGTTACTCTGTTGCAAATAGG
TGGCCTCAACATGTGTGACATGGGCGAGCCAATCAGGCAGGTGACAGTTG
TGGCCATGTTGGCCAATTTCACCAAGTCCACAGAGGATAAGCCATCGCTG
CTCAATCACGATGAGGTGGTGACGTTTTTCCATGAATTCGGGCATGTTAT
GCACGCCATCTGCTGCCAAACGGATTTTGGATATCTGACTTCATTTGACG
TTGAACGGGATTTTGTTGAATGTCCATCGCAAATGCTGGAAAATTGGTGC
TGGCAATCTGAGAGCCTGAAAATGATGTCTGGTCATTATAAGACCGGTGA
ACCTCTTGATGATGAGTTACTAAATAACTTGCTGCGTAGCCGTGTGGCCA
ATATCGCAGTTCATAATACTCGGCAGATTTGTTTGGCGAGTTTCGACCAA
ATTATCCATACAAAAACCGATGTCGATCCCGTTGAGGTGTATCAGTCGGT
TGTCAAGCAATATATGAATATCCCGGTGACAGATGGAACAAATATGCCCG
CAACATTTGGGCACATGGCTGGCGGCTATGATGCACAATATTACGGATAC
TTGTGGAGTGAAGTGTTTGCTGCAGACATGTTTATCAGCCGGTTCCAGAA
GGAGGGCTTGCTTAATGCCAAAACCGGTTCTGACTATCGGGAAATGATCT
TGAAACCCGGCAGTTCTAAGGATGCCAATGAATTGATAAAGGATTTCCTG
GGCCGTCCGCCGAACCAGGATGCATTCCTCACTCTCATGGGGTTGAGAAA
TGAGAATTCTTGATTTGCTTGTTATCTTTAAATAAATTTGTGTTGGTTTT
AAA
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protein sequence of SMED30016571-orf-1

>SMED30016571-orf-1 ID=SMED30016571-orf-1|Name=SMED30016571-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=670bp
MNKIHGINFDWITKVEEFKYRAENLKYEALHKYDVIGSEKSLTFQKIAEN
LADFELKFATQSHLLSLYQSVHPDKTFRDASTEADKILSDLKVDLSMRKD
VFDQFVKLKEIFDGKLPAQSMKYIDKKIKDGKLCGLHLDESVRKEVESIS
KELSRLKIDFEKNLSEENTILEFSIDELEGCSESFIGSLAKSETDENKRK
VSLKYPHYFPIMKHAILPETRRQMEFAFNSRCKEENGPLLKTMLQLRAKK
AKLLGFATHADYVLSNRMAKEAKVVWEFLQELREKLNSMKNEEISRYLMF
KKEMCERLKMDFNNRIDAWDMRYFMNVYEEQLFSVNHEKLRDYFPIDKVR
RGMFEIYERLLGLKFEKVEGEFWHHSVELFGVKDANDTSLLGYFFLDLYP
RDGKYGHAQVTLLQIGGLNMCDMGEPIRQVTVVAMLANFTKSTEDKPSLL
NHDEVVTFFHEFGHVMHAICCQTDFGYLTSFDVERDFVECPSQMLENWCW
QSESLKMMSGHYKTGEPLDDELLNNLLRSRVANIAVHNTRQICLASFDQI
IHTKTDVDPVEVYQSVVKQYMNIPVTDGTNMPATFGHMAGGYDAQYYGYL
WSEVFAADMFISRFQKEGLLNAKTGSDYREMILKPGSSKDANELIKDFLG
RPPNQDAFLTLMGLRNENS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0000429neoblast
Vocabulary: INTERPRO
TermDefinition
IPR024080Neurolysin/TOP_N
IPR001567Pept_M3A_M3B
IPR024077Neurolysin/TOP_dom2
IPR024079MetalloPept_cat_dom_sf
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
GO:0006518peptide metabolic process
Vocabulary: molecular function
TermDefinition
GO:0004222metalloendopeptidase activity
GO:0008237metallopeptidase activity
GO:0008233peptidase activity
GO:0016787hydrolase activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
GO:0005758mitochondrial intermembrane space
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR024080Neurolysin/Thimet oligopeptidase, N-terminalGENE3DG3DSA:1.20.1050.40coord: 2..133
e-value: 3.2E-28
score: 100.3
IPR024079Metallopeptidase, catalytic domain superfamilyGENE3DG3DSA:3.40.390.10coord: 345..498
e-value: 1.8E-193
score: 645.8
IPR001567Peptidase M3A/M3B catalytic domainPFAMPF01432Peptidase_M3coord: 212..663
e-value: 7.3E-135
score: 450.8
IPR024077Neurolysin/Thimet oligopeptidase, domain 2GENE3DG3DSA:1.10.1370.10coord: 138..659
e-value: 1.8E-193
score: 645.8
NoneNo IPR availablePANTHERPTHR11804PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATEDcoord: 11..668
NoneNo IPR availablePANTHERPTHR11804:SF50THIMET OLIGOPEPTIDASEcoord: 11..668
NoneNo IPR availableCDDcd06455M3A_TOPcoord: 43..659
e-value: 0.0
score: 792.482
NoneNo IPR availableSUPERFAMILYSSF55486Metalloproteases ("zincins"), catalytic domaincoord: 26..663