Cytochrome P450

Query:  131 YRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGI--SQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            Y      LF +  I GP P    GN++ Y    F     +  +KYGKV+ +++G  P + I DPD+++ VLVK+ +S F  R+ F     P    K+++  A  + WKRLRS ++P F+  K++ M+P+I Q  DVL+  L  E++   + + + DV    +MD+I    FG+  +   N  DPF+ + K  L         +++ + FP      I ++E  N  +   +  NFL  R ++ ++  +R + ++K R D LQL++DS+                     + KE +++        K L+  E++  + +F+FAGY+T+S  +S+I++ LA + D Q KL  EID V              YD+++++ YL+ V+ ETLR +P ++  + R+C K       NG +IPK   +++  +++H D   W   +P  F PERF + N D        +P I+ PFG GPRNCIG R ALM +KL L  ++  F   P + T+ PL+L LG  + P   V L +  R
Sbjct:   25 YGTHSHGLFKKLGIPGPTPLPFLGNILSYHKG-FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF----GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETG-KPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITV-FP----FLIPILEVLNICVFPREVTNFL--RKSVKRMKESRLEDTQKHRVDFLQLMIDSQ---------------------NSKETESH--------KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT------YDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEI---NGMFIPKGVVVMIPSYALHRDPKYW--TEPEKFLPERFSKKNKDN------IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496          

Query:  131 YRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQK--INFLKIRSTLLQIINARKKS-----SEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            Y  R   LF +  I GP P  + GN++ YR  + ++   +  +KYGK++  +EG  P + I DPD+++ VLVK+ +S F  R+       P    K+++  A  + WKR+RS ++P F+  K++ M P+I Q  DVL+  L  E++K  + + + D+    +MD+I    FG+  +   N  DPF+ S K FL       L ++++L FP +  +F    E  N  +  K  INFL       + +N  KKS      + R D LQL++DS+                     + KE +++        K L+  E+   + +F+FAGY+T+S  +S+ L+ LA + D Q KL  EID V              YD++V++ YL+ V+ ETLR +P V+  + R C K       NG +IPK + +++  +++H D   W   +P  F PERF +            +P I+ PFG GPRNCIG R ALM +KL L  ++  F   P + T+ PL+L     + P   + L +  R
Sbjct:   25 YGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGL-WKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSL----GPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKG-KPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIIL-FPFLTPVF----EALNVSLFPKDTINFLS------KSVNRMKKSRLNDKQKHRLDFLQLMIDSQ---------------------NSKETESH--------KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT------YDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEI---NGVFIPKGSMVVIPTYALHHDPKYW--TEPEEFRPERFSKKKDS-------IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495          

Query:  125 YVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGI--SQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            Y+Y  R   LF +  I GP P    GN + +R   ++    +  +KY KV+  ++   P + I DPD+++ VLVK+ +S F  R+ F     P    K ++  A  + WKR+RS ++P F+  K++ M+P+I Q  DVL+  L  E++   + + +  V    +MD+I    FG+  +   N  DPF+ + K  L         +++ + FP +  I    +E  N  +   + I+FL    ++ QI   R K ++K R D LQL++DS+                     + K+ +T+        K L+  E++  + +F+FAGY+T+S  +S+I++ LA + D Q K+  EID V              YD++++L YL+ V+ ETLR +P V+  + R+C K       NG +IPK   +++  + +H D   W   +P  F PERF + N D        +P I+ PFG GPRNCIG R AL+ +KL L  ++  F   P + T+ PL+L+LG  + P   + L +  R
Sbjct:   23 YLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKG-YWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF----GPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETG-KPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKV-FPFLTPI----LEALNITVFPRKVISFLT--KSVKQIKEGRLKETQKHRVDFLQLMIDSQ---------------------NSKDSETH--------KALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT------YDTVLQLEYLDMVVNETLRLFP-VAMRLERVCKKDVEI---NGMFIPKGVVVMIPSYVLHHDPKYW--TEPEKFLPERFSKKNKDN------IDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRLGGLLQPEKPIVLKVESR 496          

Query:  131 YRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGI--SQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERF---------LQINGDEYEFVAP----------------TNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            Y      LF +  I GP P    GN++ Y    F     +  +KYGKV+ +++G  P + I DPD+++ VLVK+ +S F  R+ F     P    K+++  A  + WKRLRS ++P F+  K++ M+P+I Q  DVL+  L  E++   + + + DV    +MD+I    FG+  +   N  DPF+ + K  L         +++ + FP      I ++E  N  +   +  NFL  R ++ ++  +R + ++K R D LQL++DS+                     + KE +++        K L+  E++  + +F+FAGY+T+S  +S+I++ LA + D Q KL  EID V              YD+++++ YL+ V+ ETLR +P ++  + R+C K       NG +IPK   +++  +++H D   W   +P  F PER          +    DE   + P                 +P I+ PFG GPRNCIG R ALM +KL L  ++  F   P + T+ PL+L LG  + P   V L +  R
Sbjct:   25 YGTHSHGLFKKLGIPGPTPLPFLGNILSYHKG-FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF----GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETG-KPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITV-FP----FLIPILEVLNICVFPREVTNFL--RKSVKRMKESRLEDTQKHRVDFLQLMIDSQ---------------------NSKETESH--------KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT------YDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEI---NGMFIPKGVVVMIPSYALHRDPKYW--TEPEKFLPERLEKRKLQSSTIPTTYDEGHQLCPYGSSVSKIFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 527          

Query:  125 YVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGI--SQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            Y+Y  R   LF +  I GP P    GN + +R   ++    +  +KY KV+  ++   P + I DPD+++ VLVK+ +S F  R+ F     P    K ++  A  + WKR+RS ++P F+  K++ M+P+I Q  DVL+  L  E++   + + +  V    +MD+I    FG+  +   N  DPF+ + K  L         +++ + FP +  I    +E  N  +   + I+FL    ++ QI   R K ++K R D LQL++DS+                     + K+ +T+        K L+  E++  + +F+FAGY+T+S  +S+I++ LA + D Q K+  EID V              YD++++L YL+ V+ ETLR +P V+  + R+C K       NG +IPK   +++  + +H D   W   +P  F PERF + N D        +P I+ PFG GPRNCIG R AL+ +KL L  ++  F   P + T+ PL+L+ G  +     + L    R
Sbjct:   23 YLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKG-YWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF----GPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETG-KPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKV-FPFLTPI----LEALNITVFPRKVISFLT--KSVKQIKEGRLKETQKHRVDFLQLMIDSQ---------------------NSKDSETH--------KALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT------YDTVLQLEYLDMVVNETLRLFP-VAMRLERVCKKDVEI---NGMFIPKGVVVMIPSYVLHHDPKYW--TEPEKFLPERFSKKNKDN------IDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496          

Query:   77 VMFIFISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTN---FSSLKMA---------LLLTFPEI-KSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPAN 1687
            ++   I +++F    +  ++RR I+  S Y ILG     +      Y          +W ++YGKV+   EG +  +VI DPDL+Q+V VKQ+ NF GRKL P Q +P++D++ ++F ++G RWKRLR+  +P FS++ +R++   +E+    L+  + + +    + I+++D  Q  T+D+I +   G +T+ Q+  N P +  ++A  G      F S  +A         ++ + P I K+  ++++   ++ + Q++  L++      I     +      D + L LD++  D ++  EN           +E   K  + +    ++QLTTEE++G   +F+ AG+DT+++++SY    LA +   Q KL  EID        +  +    +D + KL Y+  VI ETLR YP  +   +R C+++  T + N + I + TNI+ +  ++H DK +WG  D   F PER+   +GDE+ +        ++PFG GPR CIG RLA M  KL LSH++ ++ +     T+ PL+L    T  P +
Sbjct:    8 ILTSIIGVLSFYLWTWSYWKRRGIAGPSGYPILGSALEMLSSENPPYLQ------LKEWTKQYGKVYGITEGLSRTLVISDPDLVQEVFVKQYDNFFGRKLNPIQGDPNKDKRVNLFSSQGHRWKRLRTISSPTFSNNSLRKLKTTVEECAVELLRHIEQHTDGG-QPIDLLDFYQEFTLDVIGRIAMG-QTDSQMFKN-PLLPYVRAVFGEPRKGLFLSGSLAPWIGPILRMVMFSLPNIVKNPAVHVIRHTSNAVEQRVK-LRMADEKAGIDPGEPQ------DFIDLFLDAKSDDVEL--EN-----------NEDFTKAGVKV----TRQLTTEEIVGQCFVFLIAGFDTTALSLSYSSFLLATHPKVQKKLQEEIDR-------ECADPEVTFDQLSKLKYMECVIKETLRMYPLGALANSRCCMRA--TKIGNYE-IDEGTNILCDTWTLHSDKSIWG-EDAEEFKPERWE--SGDEHFYQKGG----YIPFGLGPRQCIGMRLAYMEEKLLLSHILRKYTLEVCNKTQIPLKLIGSRTTQPES 507          

Query:   80 MFIFISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLI---EYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKA---------FLGGTNF---SSLKMALLLTFPEIKSIFIYM--MER-FNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPAN 1687
            M + + +   LF  F  Y     S + +  + GP     FG ++   +Y +    +L  +W +KYG ++   EG    +V+ +P+ + +V VKQF NF+GRK  P Q +P+++++A +  A+G RWKRLR+  +P FS+  +R+++  +E+++  LM  L E S K  ++++++D  Q  T+DII +   G      L   +P +  +K          FL    F    +L   L + FP+    F  M  ME+  N  + Q+    K          A  + S +  D + L LD+        + + IE  + + F   + +K +        K LT +E+IG   +F+ AGYDT+++++SY  + LA + + Q KL  E+D        +  +    +D I KL Y+  V+ E LR YP  S + NR C+K        G  I + TN+ V+  ++H+D  +WG  D   F PER+    GDE  F A      +LPFG GPR CIG RLA+M  KL L+H++ ++    S  TE PL+L    TI P N
Sbjct:    1 MSLSLLIAGALFIGFLTYYIWIWSFWIRKGVKGPRGFPFFGVILKFHDYENPGLLKL-GEWTKKYGSIYGITEGVEKTLVVSNPEFVHEVFVKQFDNFYGRKTNPIQGDPNKNKRAHLVLAQGHRWKRLRTLASPTFSNKSLRKIMSTVEETVVELMRHLDEASAKG-KAVDLLDYYQEFTLDIIGRIAMG--QTESLMFRNPMLPKVKEIFKKGGKMPFLIAGVFPIAGTLMRQLFMKFPKFSPAFGIMNTMEKALNKRLEQRAADKK----------AGIEPSGEPQDFIDLFLDARA------NVDFIEEESTLGFAKSEVLKVD--------KHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLATHPEIQKKLQEEVDR-------ECPDPEVTFDQISKLKYMECVVKEALRMYPLASLVHNRKCMKKTNVL---GVEIDEGTNVQVDTWTLHYDPKVWG-DDASEFKPERWE--TGDEL-FYAKGG---YLPFGMGPRICIGMRLAMMEEKLLLTHILKKYTFDTSTETEIPLKLVGSATIAPRN 509          

Query:   86 IFISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQII--------NARKKSSE--KRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            +FI  +++   ++  +RRR I     Y ++G  P  +     +Y           W + YG ++ Y EG    +++ D D+++ + V+Q+ NF+GRKL P Q +P++DE+ ++F A+G RWKRLR+  +P FS++ +R++   +E S   L+  + E++ +  + I+++   Q  TMD I +   G +T+ Q+  N P +  ++A   G N   + + +   FP +  +F + M +F   +    NF+ +  T++  +        N RK   E  +  D + L L++   D +   EN  + S    +                ++QLTT+E++G   +F+ AG+DT+++++SY    LA + + Q KL  EI+    E           +D + KL Y++ +I ETLR YP  +   +R C+++  T L N + +   T + V+  S+H D  +WG  D   F PER+L  N D+           ++ FG GPR C+G RLA M  K+ L+H++ ++       TE PL+L +G        V + +++R
Sbjct:   11 LFIGFISYYLWIWTYWRRRGIPGPLGYPLVGSFPKTLKSEYPQYLQ------IRDWTKLYGPIYGYTEGTIKTLIVSDIDIVRQIFVEQYDNFYGRKLNPIQGDPEKDERTNLFSAQGFRWKRLRAISSPTFSNNSLRKINVTVEDSAMELLRHIEEQTSEG-QQIDMLQFYQEFTMDTIGRIAMG-QTDSQMFKN-PLLKFVRAIF-GDNRKHIPL-IGGVFPTLAQVFRFFMLKFP--LLGAANFIHVNKTVVTAVQNRIDQRENDRKNGIEIGEPQDFIDLFLEARADDVEHFQENNGDFSKTSSY---------------GNRQLTTQEIVGQCLVFLIAGFDTTALSLSYTTFLLATHPEVQKKLQEEIERECIEPSIS-------FDHLSKLKYMDCIIKETLRLYPLGTMANSRRCMRA--TKLGNVE-VEVGTMVQVDTWSLHTDTKIWG-DDAKEFKPERWLDPNCDQV-----FQKGGYISFGLGPRQCVGMRLAYMEEKMLLAHILRKYTFEVGTKTEIPLKL-VGRATTQPETVWMHLKQR 518          

Query:   86 IFISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGN---LIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPE--IKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENA-IESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNP-LIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPAN 1687
            I IS+V + F  +  ++RR +         GP    IFG    ++E      Y L  KW ++YGK++ + EG    +VI DPDL+Q++LVKQ+ NF+GRK  P Q +PD+D+   +  A+G RWKRLR+   PAFS+  ++++L  +E S   LM KL EES+   +++ +    Q  T D+I +   G + + Q+  N P +  +K F     +     +    F    +K +FI  + +F +G      F+ ++ ++   + +R   +++  D    +   E  D   +  NA  E  +  +  DE    ++      N++QLTT+E+I    +F+ AG+DT+++++SY+ + LA+N   Q+KL  E+D+       +  N    +D + KL Y++ VI E+LR +PF S   +R C+++    +   Q +    +++++  ++H DK++WG +D   F PER          + +P  P   +L FG GPR C+G R AL+  K  LSH++ ++    +  T+ P++L    T  P N
Sbjct:    6 ILISIVTYYFWHWTFWKRRGLP--------GPWGVPIFGKAGAMLEDSFPPGYTL-QKWTKEYGKIYGFTEGMQKVMVISDPDLVQEILVKQYDNFYGRKHNPVQGDPDKDKDIHIVGAQGFRWKRLRTITAPAFSNGSIKKVLTTMEDSTQELMKKLREESENG-KAVNMHLFYQEYTFDVISRVAMG-QPDSQMFKN-PLLKDVKGFFEHNRWQIWMFSGGFPFAVSFLKWLFI-KVGKFGAG-----PFIVVQKSVTDAVMSR--IAQREADKKHGVEPGEAADYIDMFLNARAEVEHFGESNDEFHKSSS-----YNNRQLTTQEIISQCFVFLVAGFDTTAISLSYVTYFLALNPKIQSKLQDEVDK-------ECPNDEITFDQLSKLKYMDNVIKESLRLFPFASFANSRRCMRNT---VIGEQIVEAGVDVMIDTWTLHHDKNVWG-NDVEEFKPER----------WDSPLTPQQAYLSFGAGPRVCLGMRFALLEQKGLLSHILKKYTFETNAKTQLPIKLVGRATARPEN 500          

Query:   86 IFISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRF--------DLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKS---EGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPAN 1687
            IF+ ++ +   ++  + R+ +         G P   +   L+E+ +    +L  +W +KYGKV+ Y +G    +V+ DP ++ ++ VKQF NF+GRKL P Q NP+++++  +  A+G RWKRLR+  + +FS++ +++M   +E S   L+  + +++    E I+++   Q  TMD+I +   G +T+  +  N P +  ++    G+  +   M +   FP I      +  +F      +I   K+ S +  ++ AR    E+          D + L LD+   D   +D +A    +          K N+ +    +K+L+ +EV+G   LF+  G+DT+++++SY+ + LAVN   Q K+  EI   F   E +       ++ + +L Y++ VI E LR YP  S   +R C+K+    G  +  G Y+  DT       S+H+D +LWG  D   F PER+      E++         +LPFG GPR CIG RLA+M  K+ L+HL+  +       T  PL+L    T  P +
Sbjct:   13 IFLGILTYYLWIWTYWMRKGVK-----GPRGRPFVGVLDVLLEHETPGLIKL-GEWTKKYGKVYGYTDGTQRTLVVADPAMVHEIFVKQFDNFYGRKLNPIQGNPEKEQRVHLLAAQGYRWKRLRTISSQSFSNASLKKMKRTVEDSALELLRHIEKQTAGG-EQIDMLRFYQEYTMDVIGRFAMG-QTDSMMFKN-PIVNVVREIFCGSRKNL--MLICQVFPPIGQFIRDLTFKF-----PRIPAFKLYSIMQDVVAARIAQREREKGAESGEPQDFIDLFLDARSDD---VDFSAEAREDFS--------KRNLKI----TKELSADEVVGQCFLFLIGGFDTTALSLSYVTYLLAVNPKIQEKVIEEIAREFGTSEVE-------FEKLGRLKYMDCVIKEALRLYPLASISNSRKCMKTTTVNGVKIEAGVYVQMDT------WSLHYDPELWG-EDVKEFKPERWSTDEPLEHKGA-------YLPFGLGPRQCIGMRLAIMEQKILLTHLLKNYTFETGNKTRIPLKLVGSATTSPED 505          

Query:   80 MFIFISL-VAFLFTLFYVYRRRKISLFSQYNILGPP---PNFIFGNLIEYRST-VFYELFAKWERKYGKVFVYFEG----PTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEE--SQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINA----RKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVF--AGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQ 1654
            MF+ I L +A    L Y+Y R     F+ +N  G P   P+ ++GN++ +R   V ++ F  +  KY K    F G      P   I D  L +++L+K FSNF  R    F    D+     +F   GK+WK +R  + P F+  KM+ M P + +  +  +  + E+  + ++   +EI ++M R T D+I  C FGIE N    +  P  VS    +G   F+ ++   LLT      +F++   +  S +  ++    +    ++++N     R++ + KR D + LL++ +   +  +D   +                   +  M+  +L        A +FVF  AG++TSS  MSY L+ LA N D Q++L +EI  V +E E +       Y+SI  + YLN VI ETLR Y  V   + R  L            I K T +I+   + H D+DL+   +P  F PERF        E VA    + WLPFG GPRNCIG R   M  ++ L+ +I +FR++    TE PL+
Sbjct:    1 MFVLIYLLIAISSLLAYLYHRN----FNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRG--QFHNGRDDPLTQHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECN---TLRTP--VSDFRTMGQKVFTDMRHGKLLT------MFVFSFPKLASRLRMRMMPEDVHQFFMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEV-------------------IEGMDIGELA-------AQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLT-----YESIKAMTYLNQVISETLRLYTLVPH-LERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYP--NPETFDPERF------SPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLK 485          

Query:   92 ISLVAFLFT---LFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTV--------FYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLP-LIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPK-DTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQ 1654
            ++L+  +FT   L YV  R   S +S+  + G  P +  GN+      +         Y  F   ER  G    YF   T ++ I D +L++D++++ FS+F  R LF      D+    ++ F  G  W+ LR  +   F+  KM+ M P ++E     +  KL +  +  +  IE  D+  R T D+I  C FG+E N   +    F    ++       S L  A +   PE+     + +  F   +S+   FL    T+ Q ++ R++ +  R DL+QLL++        + E  ++ +                        L+ E++   A +F  AG+DTSS  MS+ L+ LA+N D Q +L  E+  V K   +K       YDS+ ++PYL+ V+ ETLR YP +  ++ R    ++   + N   I +  + II+ VHS+H D +L+   DP  F P RF      E E +   +P  +LPFG GPRNCIG+R   + +K+ L +L+  F+ + S+ T+ PL+
Sbjct:    2 LTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGVERYCG----YFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLF--HNVRDDPLTGNLLFLDGPEWRWLRQNLTQVFTSGKMKFMFPNMVE-----VGEKLTQACRLQVGEIEAKDLCARFTTDVIGSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRL--FRPEVSE--FFL---DTVRQTLDYRRRENIHRNDLIQLLME--------LGEEGVKDA------------------------LSFEQIAAQALVFFLAGFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLT-----YDSVQEMPYLDQVVAETLRKYPILPHLLRR---STKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYP--DPEKFDPSRF------EPEEIKARHPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLK 469          

Query:  137 RRKISLFSQYNILGPPPNFIFGNLIEYR-----STVFYELFAKWERK---YGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIES--IEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPA-NGVNLGIRE 1711
            RR+   + +  I    P+ I+GN+ ++      + +F + + K++R    +   + +F   T + VI D +L++ VL+K F++F  R +F      D+   A++F   G++W+ LR  + P F+  KM+ M P+I + +   M K+        E   +EI+D++ R T D+I  C FG+  N   N N  F+   K  +    +  L   L+  FP++         R    +    +F    S +   I+ R +++EKR D +  L++                        EKE   N          L+  E++  A +F  AG++TSS  M + L+ LA++ D Q++L +EI+ V  +   +       Y+ I ++ YL  V+ ETLR YP ++  + RM  +++ +      +I K T +++    +H+D +++   +P  F PERF        E +A      WLPFG GPRNCIG R  LM   + L++LI  ++ + S  T+ P++  + + +  A NG++L + +
Sbjct:   20 RRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRSVYPFAGFYFFF---TRSAVITDLELVKRVLIKDFNHFENRGIF--YNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVK-VGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRL-----RLKLNVQDVEDFYT--SIVRNTIDYRLRTNEKRHDFMDSLIEMY----------------------EKEQAGN------TEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFT-----YEGIKEMKYLEQVVMETLRKYPVLAH-LTRMT-QTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYP--EPEKFKPERFTD------EAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEK 499          

Query:   83 FIFISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRST-----VFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPL 1651
            +I   +   L  +   Y  RK++ F +  I    P+ I GN+ E + T     +F + + K+         +F   +P   + D +L + +L+K FSNF  + +F  +K  D+   A +F   G +W+ LR+ ++  F+  KM+ M P +    +  MT +HE+  K+   +EI D++ R T+D+I  C FGI+ N   +    F+   K  L      +L    + ++P++       M R    I +  + +     + + +  R+K   KR D + +L+  E+ ++K   E  +E+ ++++                    LT EEV+  A +F  AG++TSS  M + L+ LA N D Q+K+ +E++EV ++ ++        Y+    L YLN V+ ETLR Y  V   ++RM  K           I    ++I+   ++H D  ++   +P  F PERF        E  A    + WLPFG GPRNCIG R   M  ++ L+ LI  F+ +    T NPL
Sbjct:    5 YILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEK--DDPISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKN-SVLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKL--GMVRTAPHIQEFYSRI-----VTETVAVREKEHIKRNDFMDMLI--ELKNQK---EMTLENGDVVR-------------------GLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFT-----YECTKDLKYLNQVLDETLRLYTIVPN-LDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYP--EPFEFRPERF------SPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPL 484          

Query:  110 LFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTV--FYELFAKWERKYG---KVFV-YFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKA--SMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIES---IEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLS----NGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNT 1639
            L  +FY+++RR +S + ++ +    P  + G   E+ +    F+E   K+    G   + FV  +    P +VI D +L++ V++K+F  F+ R L   Q +P  D     ++FFAR   W+ LR+ I+P F+  K+++M PL+     V + K  ++S + + S   +++ D+  R T D+I    FG+E N   +    F    +A    T    +  A++   P + S     + R      +   F  IRS++  ++  R+++ EKR DL+ +LL  +                       +E   N   P   SK++  + ++  A +F  AG++TS+  M+  L+ LA N   Q++L  EI + F + +  +      Y+ I ++PYL+ V+ ETLR YP V  I       +EG   +    +   +P   +I ++  +VH D   W   DP  + PERF   N D     A      ++PFG GPRNCIG RL L+  KL L H++   R      T
Sbjct:   10 LTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGFENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVL---QTDPHNDALGYKNLFFARSPGWRELRTKISPVFTSGKIKQMYPLM-----VKIGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALAS-----LARVKLFSRETTKF--IRSSVNYVLKERERTGEKRNDLIDILLALK-----------------------REAAAN---PGKMSKEVDLDYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHIS------YERIQEMPYLSQVVNETLRKYPIVGYIERECSQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWP--DPEKYDPERFNSSNRDNLNMDA------YMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKT 479          

Query:  125 YVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKL--HEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMM-----ERFNSGISQKIN-FLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNS-------KQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERK 1717
            Y Y     S   +  I  P P    GNL+ +R+  F++  A    KYG++  Y+ G    V+I DPD+L+ V+VK+F+ F  R        P  D   S+   +G++WKR+RS + P FS +KM+ M+PLI  + + L+  L  H ES+    S  I       TMD+I    FG + + Q N +DPF+     F   + F  + M   + FP +  +   ++     +  NS  +Q I   +K R  L           ++R D LQL+LD   T+KK +   ++E  +++   DE+    +   P   S       + +T +E++G + +F+ AGY+TSS  +++  + LAV+ + Q KL  E+DE F   E  +      Y ++ +L YL+ VI E+LR YP       R+    E   + NGQ++PK  ++ +    +H+D + W   +P  F PERF        E  A  +P ++LPFG GPR+C+G RLA + IK+ L H+  +F +   ++TE PL+LK  TT+ P NGV + I ER+
Sbjct:   33 YWYSISPFSNLERCGIKHPKPLPFIGNLMMFRNG-FFKSQADLINKYGRICGYYIGRRSTVIIADPDMLRQVMVKEFNKFPNRMTARGITKPMSD---SLIMLKGEQWKRVRSILTPTFSAAKMKEMVPLINTATETLLRNLKSHAESEN---SFNIHKCFGCFTMDVIASVAFGTQVDSQNNPDDPFVHQASKFFAFSFFRPI-MIFFMAFPFLLRLLAGLLPNKSRDEMNSFFTQCIQKMIKQRDDL--------SPEQRRKDFLQLMLDVR-TNKKFL---SVEHFDVVNDADEEAYDGHENSPANESTKRSQQKRMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHETVD------YANVQELKYLDMVICESLRLYPPAF----RVARDVEEDTVLNGQFLPKGASLEIPTGFLHYDPEHWT--EPTKFIPERFTP------EAKARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNVLACEDTEIPLELKSHTTLGPKNGVMVKITERE 540          

Query:   95 SLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQ-KNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYM-MERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQL 1657
            +LV  + TL Y+Y       F +  I GP P   FG  + Y +  F+    +  +KYGKV+  ++G  P +++ D ++++ ++VK+ +S F  R+        P  D  +++   + +RWKR+R T++P F+  +++ + P+     D  +  + +  + H + ++I +V+   ++D++    F ++ +   N +DPF+ ++K FL  + FS L + L L FP I ++   M +  F+  I   +NF     T L+ I    K S  R D L+L++ +++ D +  D  +           E+ +K            LT  E++  + +F+  GY+T+S  +S++LH+LA N D   KL  EID+ F      +      YD+++K+ YL   I E++R  P  +  + R+C K   T   NG  IPKDT + +  + ++ D  LW    P  F PERF   N  E+   A      ++PFG GPRNCIG R ALMI+KL +  L+  F +   + T+ PL+L
Sbjct:   12 TLVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLSY-TKGFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAV---KDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQK--RDHEQPVKIKEVVAPYSLDVVTSSSFSVDIDSINNPDDPFVTNIKNFLKFSLFSPLILFLTL-FPSIANLLGKMGISVFSRSI---MNFF---YTALRKIKDEHKDSNGRVDFLRLMIQNQIPDDQAKDTTS-----------EQPVK-----------GLTDHEILSQSFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPLDTPIS------YDALMKMDYLEMSINESMRLLP-TAPRLERVCKK---TVELNGITIPKDTLVAIPTYVLNRDPQLW--DSPQEFRPERFSPENKSEFLQYA------FMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLEL 482          

Query:  155 FSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLT--FPEIK--------SIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERKI*RLRFIC 1741
            F +  I GP     FG ++ Y+   F+        KYG+++  ++G  P + I D  +++ VL+K+ +S F  R+   F+ N    +  S+  A    W+R+RS ++P+F+  +++ M  ++++   +L+  + + +++  ES +I +     +MD++    F ++ +   N  DPF+ ++K  L    F  L    LL   FP +         ++F   +  F     QKI   +   T+       K +++KR D LQL++DS+   K   D    E                        K L+  E++  + +F+FAGY+TSS  +S++ ++LA N +   KL  EIDE F      +      Y++++ + YL+A + E+LR YP V+  + R+C K   T   NG  IPKD  ++V  +++H D D W   +P  F PERF + N +        +P +++PFG GPRNCIG R A + +KL +  ++ +F ++    T+ PL+L     + P + + L ++ RK+ +   +C
Sbjct:   29 FKKLGIPGPKTIPFFGTMLRYKDG-FHVFDMDCFEKYGRIWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRR--NFRLNGALYDAVSI--AEDDDWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRG-ESADIKEFFGAYSMDVVTSTAFSVDIDSLNNPKDPFVTNIKKML---KFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSDRDTKTVA------KDNTKKRVDFLQLMVDSQTGVKHKSDGEHTE------------------------KGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQAPVD------YETLMSMDYLDAALSESLRLYP-VAARLERVCKK---TVEINGLLIPKDLVVMVPTYALHRDPDYWS--EPESFKPERFTKGNKES------IDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFNGLLSPKDPIKLKLQPRKLSQSPDVC 511          

Query:  125 YVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQ-KNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQL 1657
            Y+Y       F +  I GP P   FG  + Y +  F+    +  +KYGKV+  ++G  P +++ D ++++ ++VK+ +S F  R+        P  D   ++   + +RWKR+R T++P F+  +++ + P+     D  +  + +    H + ++I +VM   ++D++    F ++ +   N +DPF+ ++K FL   N   L + LL  FP I ++   M     S  +    +  +R      I    K S  R D  +L++ +E+ D ++ D  +                      +   K LT  E++  + +F+  GY+T+S  ++++L++LA+N D   KL  +ID+ F      +      YD+++K+ YL   I E++R  P  +  + R+C K   T   NG  IPKDT I +  + ++ D  LW    PH F PERF   N  E+   A      ++PFG GPRNCIG R ALMI+KL +  L+  F +   + T+ PL+L
Sbjct:   22 YMYGVWPHGFFKKLGIPGPRPWPFFGTFLSY-TKGFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGITAV---KDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKGD--HEQPVKIKEVMASYSLDVVTSSAFSVDIDSINNPDDPFVTNIKNFLK-FNLFGLFVLLLTVFPSIANLLGKMGLSMFSKPTVDFFYKALRK-----IKEEHKDSNGRVDFFRLMIQNEIPDDQVKDTTS----------------------EQPEKGLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDKNFPLDTPIS------YDALMKIDYLEMSINESMRLLP-TAPRLERVCKK---TVEMNGITIPKDTMITIPTYVLNQDPQLW--DSPHEFRPERFSPENKSEFLQYA------FMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIPLEL 482          

Query:  149 SLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQ-KNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQL 1657
              F +  I GP P   FG  + Y +  F+    +  +KYGKV+  ++G  P +++ D ++++ ++VK+ +S F  R+        P  D   ++   + +RWKR+R T++P F+  +++ + P+     D  +  + +    H + ++I +VM   ++D++    F ++ +   N +DPF+ ++K FL   N   L + LL  FP I ++   M     S  +    +  +R      I    K S  R D  +L++ +E+ D ++ D  +                      +   K LT  E++  + +F+  GY+T+S  ++++L++LA+N D   KL  +ID+ F      +      YD+++K+ YL   I E++R  P  +  + R+C K   T   NG  IPKDT I +  + ++ D  LW    PH F PERF   N  E+   A      ++PFG GPRNCIG R ALMI+KL +  L+  F +   + T+ PL+L
Sbjct:    9 GFFKKLGIPGPRPWPFFGTFLSY-TKGFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGITAV---KDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKGD--HEQPVKIKEVMASYSLDVVTSSAFSVDIDSINNPDDPFVTNIKNFLK-FNLFGLFVLLLTVFPSIANLLGKMGLSMFSKPTVDFFYKALRK-----IKEEHKDSNGRVDFFRLMIQNEIPDDQVKDTTS----------------------EQPEKGLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDKNFPLDTPIS------YDALMKIDYLEMSINESMRLLP-TAPRLERVCKK---TVEMNGITIPKDTMITIPTYVLNQDPQLW--DSPHEFRPERFSPENKSEFLQYA------FMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIPLEL 461          

Query:  152 LFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFN-SGISQKI-NFLKIRSTLLQIINARKKSS-EKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFL---QINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQL 1657
            LF +Y I GP P    G  +  R  +  E   +  +KYGKV+  +EG  P + I DP +++ ++VK+ ++NF  R+ F          K+S+  ++ ++WKR+R+ ++P F+  K+++M PL+    ++L+  +H++     E +++  +    +MDI+    F +  +   N NDPF+ + +     + F+ L +  +L         + ++++ N   +S KI NF K    +  I   R+K + E R D LQL++D++  + K + E                        K   K+L+  E++  + +F+ AGY+T+S  + ++ +++A + D Q KL  EID +              YD+++K+ Y++ VI E+LR +P    I +R+C K   T   NG  IP    I+V + ++H + ++W   +P  F PERF    Q N D Y F         LPFG GPRNCIG R AL+ +K+ L+ L+  FR+   ++T  PL++
Sbjct:   24 LFKRYGIPGPTPIPFIGTFLGNRHGLM-EFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLSG----PLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINNK-EPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILC-----PFLVPLLDKMNFCFLSLKILNFFK--DAVASIKKKRQKGTHEDRVDFLQLMVDAQSNEGKSVPEEE----------------------KHGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPT------YDALMKMEYMDMVINESLRMFPPAIRI-DRVCKK---TMEINGVTIPAGVVIVVPLFALHLNPEIW--PEPEEFQPERFSKENQKNQDPYNF---------LPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCKDTPVPLKI 476          

Query:  152 LFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFN-SGISQKI-NFLKIRSTLLQIINARKKSS-EKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFL---QINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGI 1705
            LF +Y I GP P    G  +  R  +  E   +  +KYGKV+  +EG  P + I DP +++ +++K+ +SNF  R+            K+S+  ++ ++WKR+R+ ++P F+  K+++M PL++   ++L+  +H++     E +++  +    +MDI+    F +  +   N NDPF+ + +     + F+ L +  +L         + ++++ N   +S KI NF K    +  I   R+K + E R DLLQL++D++  + + + E                        K   K+L+  E++  + +F+ AGY+T+S  + ++ +++A + D Q KL  EID +              YD+++K+ Y++ VI ETLR +P    I +R+C K   T   NG  IP    I+V +  +H + ++W   +P  F PERF    Q N D Y F         LPFG GPRNCIG R AL+ +KL L+ L+  FR    ++T  PL++     + P   + L +
Sbjct:   32 LFKRYGIPGPTPIPFIGTFLGNRKGLM-EFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMIKECYSNFTNRRDLGLTG----PLKSSVLVSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKIDNK-EPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFKFSFFNPLFLIAILC-----PFLVPLLDKMNFCFLSLKILNFFK--DAVASIKKKRQKGTHEDRVDLLQLMVDAQSNEGESVPEEE----------------------KHGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPT------YDALMKMEYMDMVINETLRMFPPAIRI-DRVCKK---TMEINGVTIPAGVVIVVPLFVLHLNPEIW--PEPEEFQPERFSKENQKNQDPYNF---------LPFGVGPRNCIGMRFALVNMKLVLTILLQNFRFETCKDTPVPLKICTDGYLKPTKPIILNL 500          

Query:  152 LFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFN-SGISQKINFLKI-RSTLLQIINARKKSSE-KRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFL---QINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGI 1705
            LF +Y I GP P    G  +  R  +  E   K  +KYG V+ +++GP P + I DP +++ ++VK+ ++NF  R+ F          K+S+  ++ ++WKR+R+ ++P F+  K+++M PL++   ++L+  +H++     E +++  +    +MD I    F +  +   N NDPF+ + +       FS  K   L+T   +    + ++++ N   +S K  FLK  +  +  I   R+K +   R D LQL++D++  + + + E                        K   K+L+  E++  + +F+ AGY+T+S  + ++ +++A   D Q KL  EI+ +              YD+++K+ Y++ VI ETLR  P    I +R+C K   T   NG  IP    I+V + ++H + ++W   +P  F PERF    Q N D Y F         LPFG GPRNCIG R AL+ IKL L+ L+  F++   ++T  PL++     + P   + L +
Sbjct:   32 LFKRYGIPGPTPIPFIGTFLGNRHGLM-EFDMKCFKKYGNVWGFYDGPQPVLAILDPVIIKSIMVKECYTNFTNRRDFGLSG----PLKSSVLMSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKIDNK-EPLDMKSIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLF---TFSFFKPLFLITI--LCPFLVPLLDKMNFCFLSSK--FLKFFKDAVASIKKKRQKGAHMDRVDFLQLMVDAQSNEGESVPEEE----------------------KHRHKELSDTEILAQSLIFIMAGYETTSTTLMFLTYNIARYPDVQRKLEEEINTLLPNKAPPT------YDALMKMEYMDMVINETLRLLPPAIRI-DRVCKK---TMEINGVTIPAGVVIVVPLFALHLNPEIWP--EPEEFQPERFSKENQKNQDPYNF---------LPFGVGPRNCIGMRFALVNIKLALTILLQNFKLETCKDTPVPLKVCTRGNLKPTKPIILNL 500          

Query:  152 LFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFN-SGISQKI-NFLKIRSTLLQIINARKKSS-EKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFL---QINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNT 1639
            LF +Y I GP P    G  +  R  +  E   +  +KYGKV+  +EG  P + I DP +++ ++VK+ ++NF  R+ F          K+S+  ++ ++WKR+R+ ++P F+  K+++M PL+    ++L+  +H++     E +++  +    +MDI+    F +  +   N NDPF+ + +     + F+ L +  +L         + ++++ N   +S KI NF K    +  I   R+K + E R D LQL++D++  + K + E                        K   K+L+  E++  + +F+ AGY+T+S  + ++ +++A + D Q KL  EID +              YD+++K+ Y++ VI E+LR +P    I +R+C K   T   NG  IP    I+V + ++H + ++W   +P  F PERF    Q N D Y F         LPFG GPRNCIG R AL+ +K+ L+ L+  FR+   ++T
Sbjct:   24 LFKRYGIPGPTPIPFIGTFLGNRHGLM-EFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLSG----PLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINNK-EPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILC-----PFLVPLLDKMNFCFLSLKILNFFK--DAVASIKKKRQKGTHEDRVDFLQLMVDAQSNEGKSVPEEE----------------------KHGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPT------YDALMKMEYMDMVINESLRMFPPAIRI-DRVCKK---TMEINGVTIPAGVVIVVPLFALHLNPEIWP--EPEEFQPERFSKENQKNQDPYNF---------LPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCKDT 470          

Query:  149 SLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIF-IYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
             LF +  I GP P    G  +E+R  +  +   +  +KYG+++  ++G  P + I DP +++ +LVK+ ++NF  R+ F     P E   +++  A  ++WKR+RS ++P F+  K++ M  +++   D+L+  +     K  E     DV+   +MD+I    F +  +   N ++PF++ +K  L  T F S  +   + FP ++ IF +  +  F    +Q   F+   ++  +    +K     R DLLQL++DS  T+         +SSN                     K LT  E++  + +F+FAGY+T+S A+SY+ ++LA + D Q KL  EID    +           YD ++++ YL+ VI ETLR +P       R+   S+     NG  IPK T  ++  + +  D + W   +P  F PERF + N       A   P  +LPFG GPRNCIG R AL+ +K+ ++ L+  F + P   T  P++      + P   + L    R
Sbjct:    9 GLFKKMGIPGPTPLPFIGTFLEFRKGMI-QFDIECFKKYGRMWGMYDGRQPVLAIMDPAIIKTILVKECYTNFTNRRNFGLN-GPLE---SAITVAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNVQVSVDKD-EPCATKDVIGAYSMDVITSTSFSVNIDSLQNPSNPFVIHIKNLLK-TGFLSPVIIFAVIFPFLRPIFEVLNISFFPKDFTQ--FFMNAVTSFRE--KRKKGDHSGRVDLLQLMVDSGTTEGN-------DSSN-------------------QHKALTDAEIMAQSLIFIFAGYETTSTALSYLFYNLATHPDVQQKLHEEIDSFLPDKASPT------YDILMQMEYLDMVIQETLRLFP----PAGRLERVSKQNVEINGVSIPKGTVAMIPAYVLQRDPEYW--PEPEEFRPERFSKENR------ATQTPFTFLPFGDGPRNCIGLRFALLSMKVAIATLLQNFSVRPCAETLIPMEFSTIGVLQPKKPIVLKFLSR 477          

Query:   98 LVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            L+A    L Y Y  RK  LF +  I GP P    G ++ Y   + ++   +  +KYGK +  F+G TP + + DP+ +++VLVK+ FS F  R+ F     P      ++  ++   WKR R+ ++P F+  K++ M P+IEQ  D+L+  L ++++K  + + + DV+   +MD+I    FG+  +   N  DPF+   K  L    F  L  +++L FP +  ++    E  N  +  K +    +  + ++  +R  S +K R D LQL+++S    K                             K++ K L+  E+   + +F+FAGY+T+S  +S+ LHSLA + D Q KL  EIDE               YD+++++ YL+ V+ ETLR YP ++  + R+C K       NG YIPK + +++  +++H D   W   +P  F PERF + N          +P ++LPFG GPRNC+G R ALM +KL L+ ++  F   P + T+ PL+L     + P   + L +  R
Sbjct:   14 LLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYKGL-WKFDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDF----GPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKG-KPVTMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVL-FPFLTPVY----EMLNICMFPKDSIEFFKKFVDRMKESRLDSKQKHRVDFLQLMMNSHNNSKD----------------------------KVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPT------YDTVMEMEYLDMVLNETLRLYP-IANRLERVCKKDVEL---NGVYIPKGSTVMIPSYALHHDPQHWS--EPEEFQPERFSKENK------GSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKVVPR 497          

Query:   98 LVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            L+A    L Y+Y      +F +  I GP P    G ++ Y+   F+E   +  +KYGK++  ++G  P + I DPD+++ VLVK+ +S F  R+ F     P    K ++  +  + WKR+R+ ++P F+  +++ M P+I Q  DVL+  + +   +  +   + D+    +MD+I    FG+  +   N  DPF+  +K  L    F  L +++ L FP +  +F    +  N  +  +       +++ ++   R K  EK R D LQL+++S+                          KT     K + K L+  E++  + +F+FAGY+T+S A+S+ L+ LA++ D Q KL  EID                YD+++++ YL+ V+ ETLR YP ++  + R+C         NG +IPK T +++   ++H D   W   +P  F PERF + N D        NP ++LPFG GPRNCIG R AL+ +K+ L  ++  F + P + TE PL+L     + P N + L +  R
Sbjct:   14 LLATSLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYQKG-FWECDIQCHKKYGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRF----GPVGILKKAISISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEG-KPTSMKDIFGAYSMDVITATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTL-FPFLTPVF----DALNVSLFPRDVISFFTTSVERMKENRMKEKEKQRVDFLQLMINSQ------------------------NYKT-----KESHKALSDVEIVAQSVIFIFAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAALPNKAPAT------YDTLLQMEYLDMVVNETLRLYP-IAGRLERVCKTDVEI---NGLFIPKGTVVMIPTFALHKDPKYW--PEPEEFRPERFSKKNQDS------INPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGLLQPENPLLLKVVSR 496          

Query:  125 YVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERKI 1720
            Y Y  R   LF +  I GP P    G ++ Y   + ++   +   KYGK +  F+G  P  VI DP+++++VLVK+ FS F  R+ F     P      ++  ++ + WKR R+ ++P F+  K++ M P+IEQ  D+L+  L +E++K  + + + DV+   ++D+I    FG+  +   N  DPF+   K  L    F  L  +++L FP +  ++    E  N  +  K +    +  + ++  +R  S +K R D LQL++++    K                             K + K L+  E+   + +F+FAGY+T+S  +S+ L+ LA + D Q KL  EIDE               YD+++++ YL+ V+ ETLR YP +   + R C K       NG YIPK + +++  +++H D   W   +P  F PERF + N          +P +++PFG GPRNCIG R A M +KL L+ ++  F   P Q T+ PL+L     + P   + L +  R +
Sbjct:   23 YRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYKGL-WKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREF----GPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKG-KPVTMKDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVL-FPFLTPVY----EMLNICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKD----------------------------KDSHKALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKAPPT------YDTVMEMEYLDMVLNETLRLYP-IGNRLERFCKKDVEL---NGVYIPKGSTVMIPSYALHHDPQHW--PEPEEFQPERFSKENK------GSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLLQPEKPIVLKVVPRDV 499          

Query:  125 YVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERKI 1720
            Y Y  R   LF +  I GP P    G ++ Y   + ++   +   KYGK +  F+G  P  VI DP+++++VLVK+ FS F  R+ F     P      ++  ++ + WKR R+ ++P F+  K++ M P+IEQ  D+L+  L +E++K  + + + DV+   ++D+I    FG+  +   N  DPF+   K  L    F  L  +++L FP +  ++    E  N  +  K +    +  + ++  +R  S +K R D LQL++++    K                             K + K L+  E+   + +F+FAGY+T+S  +S+ L+ LA + D Q KL  EIDE               YD+++++ YL+ V+ ETLR YP +   + R C K       NG YIPK + +++  +++H D   W   +P  F PERF + N          +P +++PFG GPRNCIG R A M +KL L+ ++  F   P Q T+ PL+L     + P   + L +  R +
Sbjct:   23 YRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYKGL-WKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREF----GPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKG-KPVTMKDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVL-FPFLTPVY----EMLNICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKD----------------------------KDSHKALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKAPPT------YDTVMEMEYLDMVLNETLRLYP-IGNRLERFCKKDVEL---NGVYIPKGSTVMIPSYALHHDPQHW--PEPEEFQPERFSKENK------GSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLLQPEKPIVLKVVPRDV 499          

Query:  113 FTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
              LFY+Y      LF +  I GP P  + G +  Y   + ++      +KYGK++ ++EGP P + I DP++++ VLVK+ +S F  R+ F     P    K ++  +  + WKRLR+ ++P F+  K++ M P++ Q  D+L+  L  E +K  E I + D+    +MD+I    FG+  +   N  DPF+   K  L    F    ++++L FP +  I  Y M  F+      +NF K    + ++   R  S++K R D LQL+++++       +    ES                       K L+  E+   A +F+F GYD +S ++S I++ LA + D Q KL  EID                YD+++ + YL+ V+ E+LR YP    I  R+   S+     NG +IPK T +++ ++ +H + + W   +P  F PERF + N          +P I++PFG GPRNCIG R AL+ IKL +  ++  F + P + T+ PL++       P   + L +  R
Sbjct:   19 LVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGM-WKFDEDCYKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFF----GPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKG-EPISMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSIIL-FPFLTPI--YEMLNFSIFPRDSMNFFK--KFVKRMKKERLASNQKNRVDFLQLMMNTQ-------NSKGQESQ----------------------KALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAPVT------YDALMDMEYLDMVVNESLRLYP----IAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYW--PEPQEFCPERFSKENKGN------IDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQPEKPIILKVVSR 496          

Query:   98 LVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            L+A    L Y+Y      LF +  + GP P   FGN++ YR  V  E   +  +KYGK++  FEG  P +VI DPD+++ VLVK+ +S F  R++F     P    K ++  A  ++WKR+R+ ++P F+  K++ M P+I +  DVL+  L +E++K  +S+ + D+    +MD+I    FG+  +   N  DPF+ + K  L         ++++L FP +  IF    E  N  +  K     +  ++ +I  +R K ++K R D LQL+++S         +N+ E+                     N K L+ +E++  + +F+FAGY+T+S  +S++L+ LA + D Q KL  EID  F             YD + ++ YL+ V+ ETLR +P ++  ++R+C K    H   G  IPK T + V +  +H D  LW   +P  F PERF + N D        NP ++LPFG GPRNCIG R A+M +KL +  ++  F   P + T+ PL++     I P   + L +  R
Sbjct:   14 LLAISLVLLYLYGTYSHGLFKKLGVSGPRPLPYFGNVLSYRKGV-CEFDEECFKKYGKMWGVFEGKQPLLVITDPDVIKTVLVKECYSVFTNRRVF----GPMGIMKNAVSVAEDEQWKRIRTLLSPTFTSGKLKDMFPIIGKYGDVLVRNLRKEAEKG-KSVNMKDIFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFNILDPFLLSVVL-FPFLVPIF----EVLNITMFPKSAVDFLTKSVKRIKESRLKDNQKPRVDFLQLMINS---------QNSKETD--------------------NHKALSDQELMAQSVIFIFAGYETTSNTLSFLLYILATHPDVQQKLQEEIDATFPNKAPPT------YDVLAQMEYLDMVVNETLRMFP-IAVRLDRLCKKDVEIH---GVSIPKGTAVTVPIFVLHRDPQLW--PEPEEFRPERFSKKNKDS------INPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKINSQGLIRPEKPIFLKVVLR 496          

Query:  149 SLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYM-MERFNSGISQKINFLKIRSTLLQIINARKKSSEKR-FDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
             LF +  I GP P    G ++EYR  + ++   +  +KYGK++  F+G  P +VI DPD+++ VLVK+ +S F  R+ F     P    K ++  +  + WKR+R+ ++P F+  K++ MLP+I Q  DVL+  L +E++K  + +++ ++    +MD+I    FG+  +   N  DPF+ +++  L  + F  L +++ L FP +  IF  + +  F   +   ++FLK  +++ +I + R K  +KR  D LQL+++S+                     + KEI ++        K L   EV+  + + +FAGY+T+S  +S+I+H LA + D Q KL  EID +    E         YD++VK+ YL+ V+ ETLR YP ++  + R+C K       NG +IPK T +++  +++H D   W   +P  F PERF + N D        NP I+ PFG GPRNC+G R ALM IKL L  L+  F     + T+ PL+L     + P   + L +  R
Sbjct:   29 GLFKKMGIPGPTPLPFIGTILEYRKGI-WDFDIECRKKYGKMWGLFDGRQPLMVITDPDMIKTVLVKECYSVFTNRRSF----GPVGFMKKAVSISEDEDWKRVRTLLSPTFTSGKLKEMLPIIAQYGDVLVKNLRQEAEKG-KPVDLKEIFGAYSMDVITGTSFGVNIDSLRNPQDPFVKNVRRLLKFSFFDPLLLSITL-FPFLTPIFEALHISMFPKDV---MDFLK--TSVEKIKDDRLKDKQKRRVDFLQLMINSQ---------------------NSKEIDSH--------KALDDIEVVAQSIIILFAGYETTSSTLSFIMHLLATHPDVQQKLQEEIDTLLPNKELAT------YDTLVKMEYLDMVVNETLRLYP-IAGRLERVCKKDVDI---NGTFIPKGTIVMMPTYALHRDPQHW--TEPDEFRPERFSKKNKDN------INPYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKLCKETQVPLKLGKQGLLQPEKPIVLKVVSR 494          

Query:   98 LVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            L+A    L Y Y  RK  LF +  I GP P    G ++ Y   + ++   +  +KYGK +  F+G TP + + DP+ +++VLVK+ FS F  R+ F     P      ++  ++   WKR R+ ++P F+  K++ M P+IEQ  D+L+  L ++++K  + + + DV+   +MD+I    FG+  +   N  DPF+   K  L    F  L  +++L FP +  ++    E  N  +  K +    +  + ++  +R  S +K R D LQL+++S    K                             K++ K L+  E+   + +F+FAGY+T+S  +S+ LHSLA + D Q KL  EIDE               YD+++++ YL+ V+ ETLR YP ++  + R+C K       NG YIPK + +++  +++H D   W   +P  F PERF + N          +P ++LPFG GPRNC+G R ALM +KL L+ ++  F   P + T+ PL+L     + P   + L +  R
Sbjct:   14 LLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYKGL-WKFDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDF----GPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKG-KPVTMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVL-FPFLTPVY----EMLNICMFPKDSIEFFKKFVDRMKESRLDSKQKHRVDFLQLMMNSHNNSKD----------------------------KVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPT------YDTVMEMEYLDMVLNETLRLYP-IANRLERVCKKDVEL---NGVYIPKGSTVMIPSYALHHDPQHWS--EPEEFQPERFSKENK------GSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKVVPR 497          

Query:  131 YRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGI--SQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            Y      LF +  I GP P    GN++ Y    F     +  +KYGKV+ +++G  P + I DPD+++ VLVK+ +S F  R+ F     P    K+++  A  + WKRLRS ++P F+  K++ M+P+I Q  DVL+  L  E++   + + + DV    +MD+I    FG+  +   N  DPF+ + K  L         +++ + FP      I ++E  N  +   +  NFL  R ++ ++  +R + ++K R D LQL++DS+                     + KE +++        K L+  E++  + +F+FAGY+T+S  +S+I++ LA + D Q KL  EID V              YD+++++ YL+ V+ ETLR +P ++  + R+C K       NG +IPK   +++  +++H D   W   +P  F PERF + N D        +P I+ PFG GPRNCIG R ALM +KL L  ++  F   P + T+ PL+L LG  + P   V L +  R
Sbjct:   25 YGTHSHGLFKKLGIPGPTPLPFLGNILSYHKG-FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF----GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETG-KPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITV-FP----FLIPILEVLNICVFPREVTNFL--RKSVKRMKESRLEDTQKHRVDFLQLMIDSQ---------------------NSKETESH--------KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT------YDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEI---NGMFIPKGVVVMIPSYALHRDPKYW--TEPEKFLPERFSKKNKDN------IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496          

Query:  131 YRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQK--INFLKIRSTLLQIINARKKS-----SEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            Y  R   LF +  I GP P  + GN++ YR  + ++   +  +KYGK++  +EG  P + I DPD+++ VLVK+ +S F  R+       P    K+++  A  + WKR+RS ++P F+  K++ M P+I Q  DVL+  L  E++K  + + + D+    +MD+I    FG+  +   N  DPF+ S K FL       L ++++L FP +  +F    E  N  +  K  INFL       + +N  KKS      + R D LQL++DS+                     + KE +++        K L+  E+   + +F+FAGY+T+S  +S+ L+ LA + D Q KL  EID V              YD++V++ YL+ V+ ETLR +P V+  + R C K       NG +IPK + +++  +++H D   W   +P  F PERF +            +P I+ PFG GPRNCIG R ALM +KL L  ++  F   P + T+ PL+L     + P   + L +  R
Sbjct:   25 YGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGL-WKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSL----GPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKG-KPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIIL-FPFLTPVF----EALNVSLFPKDTINFLS------KSVNRMKKSRLNDKQKHRLDFLQLMIDSQ---------------------NSKETESH--------KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT------YDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEI---NGVFIPKGSMVVIPTYALHHDPKYW--TEPEEFRPERFSKKKDS-------IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495          

Query:  134 RRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKL--HEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVT-DKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNL 1699
            R+ K+ +F +  I GP PNF+FGNL+ +     ++ + +W R+YGK F YFEGPTP +V  D +LLQ V VKQF  FH RK+FP Q +PD DE   MFFARG+RW+RLRS +NPAFS +KMR M PLI   ID L+  +  H  + +  +S E+    QRLT+D I  C FG+ TN  +N +D  I + +  +  T    +   L   FP +  ++I +   F   +S    F  + S++ +II  +KK    + +LL+L+L SE   D   ID   ++             + N+    +  + LT EE++    LF+ AGY+T+S  ++YI++ ++VN +AQ +L  EIDE+F E  +        YD I K+ YL+ V  ETLR YP  ST++ R C++S      NG  IPK   +  NV SVH++++ W   D   F PERF +    E       +PL W+PFG GPR C+G RLA +  K+T+  ++ ++   PS+  E P+Q   G TI P +GVN+
Sbjct:    3 RKEKMQIFEKMGIPGPKPNFLFGNLLAFWRMPLFKKYQEWYREYGKTFGYFEGPTPVLVTADVELLQQVFVKQFKKFHARKVFPVQVDPDSDENVHMFFARGERWRRLRSIVNPAFSSTKMRTMTPLINHRIDQLLDIVDDHNVNDRSFDSYEL---FQRLTLDTIADCGFGMNTNALINNDDECIKNCRGVIRDTTKRPILFMLGFIFPALHRLWITIYN-FMHFVSFNPVFC-LESSMRKIIRNQKKQKPSKSNLLELMLTSEFNPDADEIDVGDVDQ------------RDNV----VKRRLLTNEELVAQCLLFLLAGYETTSTTLAYIMYEMSVNPEAQKRLQEEIDELFPENADNPS-----YDQIQKMEYLDMVWCETLRKYPLASTVVARQCMESCTV---NGIDIPKGMLVQANVWSVHYNQEHWV-EDTQRFIPERFTEQRKSE------RHPLAWMPFGSGPRTCVGLRLAQLEGKMTIIRMLKKYSFVPSETQEIPIQCVEGATILPKDGVNV 491          

Query:   92 ISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKS---EGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERKI 1720
            I+LV  L   FY  RR K+ +F +  I GP P+F+FGNL+ +    FY  + +W R+YGK F YFEGPT  +V  + +LL +V VKQF  FH RK+FP Q +PD DE   MFFARG+RW+RLRS INPAFS +KMR M P+I   ID LM ++ +   ++ +  ++ DV QRLTMD I +C  G+E +   N +D ++   +  +  T    L   L   FP+   ++I + +         + +L+    + +I++ RK S E + DLL L+L+SE      I+E  +++++ +                +  + LTTEE+   + LF+ AGY+T+S  ++YI + +AVN + Q KL  EID  F +  +        Y++I ++ YL+ V  ETLR  P  ST++ R C+++   EG  L+ G  I        NV ++H++ +LWG  DP  F PERF        E     NP+ W+PFG GPR C+G RLA +  K+ +  L  ++ + PS+    PL+   G TI P +GV++ +  R I
Sbjct:    9 IALV--LLVAFYRQRREKMQVFGRMGIPGPGPHFLFGNLLSFFRKSFYIKYQEWYREYGKTFGYFEGPTAVLVTTNLELLHEVFVKQFKKFHARKVFPVQVDPDRDENVHMFFARGERWRRLRSIINPAFSTTKMRNMTPMINTRIDHLM-EVVDTYGRNRDDFDVYDVFQRLTMDTIAQCGLGLENSSLKNPDDCWLKHSRKVITDTTKRPLLFLLGFIFPKFHELWITIYKLLGYLSFNPVFWLE--KMVKEIVDRRKDSQETKVDLLHLMLNSEYDPATGIEE--LDATDKV----------------VRKRLLTTEELTAQSLLFLLAGYETTSTTLAYIFYEMAVNPEVQAKLQEEIDRYFPDQADNPS-----YEAIQRMEYLDMVWCETLRKCPLASTVVARECMENCTIEGVKLTKGMLIH------ANVWALHYNAELWG-EDPDQFVPERFTA------ERKKMRNPMAWMPFGSGPRTCVGLRLAQLQGKMAMIRLFKKYTVVPSEKLSIPLKYVEGATIIPKDGVSIRVIRRNI 513          

Query:   86 IFISLVAFLFT-----LFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQK-HIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKK-SSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            +F++L+ F F+     LFY  R+ +++ F +  I GP PNF+FGNL+E++    Y+   +W++KYG  + Y+EGPTP +V  D ++L++V VKQF+NFH RKL+P Q +PD+DE   MFFARG+RWKRLR  +NPAFS +K+R+M P + + I+ L+  + + + K   +++E++D+ +RLT+D I +C  GI+ N   N +DP +   K  +  T  +     L   FP +  ++I + +  ++       +L+ R  + ++++ R+  ++E R DL+Q +LD++             S ++   E+E    +N P  K   K +T EE++  A LF+ AGY+T+S  ++Y+   L+ N   Q +L  EI  V              YD + +L YL+ VI+ETLR YP  ST+  R C++     + N Q IP    +  N+  VH+D   WG  DP  F P RF+     +    A      W+PFGGGPR C G R AL+ +K+ +S ++  F   PS     PL LK G TI PA GV+L  R R
Sbjct:    1 MFLTLILFTFSTGLMYLFYRSRKDRMTFFQKMGIPGPEPNFLFGNLLEFQKVPLYKKHQEWKQKYGTTYGYYEGPTPVLVTSDVNILEEVFVKQFNNFHARKLWPVQVDPDKDEDVHMFFARGRRWKRLRGVVNPAFSAAKIRKMTPTVNECINHLLDVMRDTANKTSHKTVELLDIFRRLTLDTILRCEVGIDQNSLKNPDDPILNHCKGVINDTVKTPWLFLLGFLFPSLHCVWITLYKFLHNIKCNPAFWLEDR--MREVVSMRRTLTNEHRNDLMQQMLDAQFA-----------SDSVKDLENEASKISN-PYKKF-LKSMTNEEIVSHALLFLLAGYETTSTTLAYLFFELSQNPHVQQRLRLEIMAVLPRGYHTIE-----YDDLKQLTYLDYVIWETLRKYPLASTVTARQCMRD--CTVGNMQ-IPMGMLVHANLWDVHYDPTHWG-EDPQSFNPLRFMPEQRRKRHATA------WMPFGGGPRACAGIRFALLQLKMVVSKVLRDFDFYPSDKLIVPLPLKQGATILPAEGVHLSARRR 520          

Query:   89 FISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLT--FPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSE-KRFDLLQLLLDSEVT-DKKMIDENAIESSNLMKFEDEKEIKTNIPMP----KMNSKQ---------------------LTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERKI 1720
             I +   L  ++   R+ +   F    + GPPPN + GNL EY      E  AK  +KYGK +  FEGP P V+  D +LL++V +K+FS+FHGRKLFP Q +P++    SM  A G RWKRLR   NP FS SKM++M PLI +++   + K  EE  K  +  +I    Q LTM++I  C FG++ N   +   PF+++ + F       S+K  +++   FP ++ +F  M+      +  + +  ++R    + I  RK   + +R DLLQL++D+ +  +K+ +  +    +  + F   KE +    +     +MN  Q                     L+ EE++    +F+ AGY+T+S A+ Y  H LA+N + Q +L +EIDE   + +  N      Y++I KLPYL  V  E LR +P  +T +NR C++       NG +IP   ++  +V S+H D ++WGP DP +F PERF   N       A  +P+ WLPFG GPRNC+G R A++  K+ L+ ++  F I     TE PL+     T  P NGV + + +R+I
Sbjct:    5 LIGVTCVLLGIWIWQRKERFKYFKNMGLDGPPPNLLLGNLGEYGGGNIAEGIAKLTKKYGKTYGIFEGPVPCVITTDLELLKEVFIKRFSSFHGRKLFPVQPDPEDAHGISMVTAVGPRWKRLRMITNPTFSVSKMKQMSPLINEAVTSFL-KTCEEKAKEGKPFDIYKEYQGLTMEVIASCAFGLQINTIQDKEHPFLLAGRDFFNKLGKDSMKFYMMIPAIFPILRRLFYAMLYMAQCYMPNEPSG-RLRKFARETIQLRKSDPKYRRMDLLQLMIDATLAGNKEQVSRSNSSENGELSFGGAKEQEGTNGLAGVDGEMNGVQGTAGDVANGTGNLKTSPQKSGLSKEEIVEQCLVFIIAGYETTSTALGYCSHELALNPEVQKRLQAEIDEQLGDEDHIN------YETIQKLPYLEMVFCEALRLHPIATTFINRRCMEP---CTVNGLHIPAGLSVQADVLSIHADPEVWGPTDPAVFEPERFSPEN------KATRHPMAWLPFGAGPRNCVGMRFAILEAKIALARVLKHFTIERCAETEVPLKKVERATTVPMNGVTVKLVKREI 560          

Query:  146 ISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQK-HIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKK-SSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            ++ F +  I GP PNF+FGNL+E++    Y+   +W++KYG  + Y+EGPTP +V  D ++L++V VKQF+NFH RKL+P Q +PD+DE   MFFARG+RWKRLR  +NPAFS +K+R+M P + + I+ L+  + + + K   +++E++D+ +RLT+D I +C  GI+ N   N +DP +   K  +  T  +     L   FP +  ++I + +  ++       +L+ R  + ++++ R+  ++E R DL+Q +LD++             S ++   E+E    +N P  K   K +T EE++  A LF+ AGY+T+S  ++Y+   L+ N   Q +L  EI  V              YD + +L YL+ VI+ETLR YP  ST+  R C++     + N Q IP    +  N+  VH+D   WG  DP  F P RF+     +    A      W+PFGGGPR C G R AL+ +K+ +S ++  F   PS     PL LK G TI PA GV+L  R R
Sbjct:    1 MTFFQKMGIPGPEPNFLFGNLLEFQKVPLYKKHQEWKQKYGTTYGYYEGPTPVLVTSDVNILEEVFVKQFNNFHARKLWPVQVDPDKDEDVHMFFARGRRWKRLRGVVNPAFSAAKIRKMTPTVNECINHLLDVMRDTANKTSHKTVELLDIFRRLTLDTILRCEVGIDQNSLKNPDDPILNHCKGVINDTVKTPWLFLLGFLFPSLHCVWITLYKFLHNIKCNPAFWLEDR--MREVVSMRRTLTNEHRNDLMQQMLDAQFA-----------SDSVKDLENEASKISN-PYKKF-LKSMTNEEIVSHALLFLLAGYETTSTTLAYLFFELSQNPHVQQRLRLEIMAVLPRGYHTIE-----YDDLKQLTYLDYVIWETLRKYPLASTVTARQCMRD--CTVGNMQ-IPMGMLVHANLWDVHYDPTHWG-EDPQSFNPLRFMPEQRRKRHATA------WMPFGGGPRACAGIRFALLQLKMVVSKVLRDFDFYPSDKLIVPLPLKQGATILPAEGVHLSARRR 495          

Query:  152 LFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGI--SQKINFLKIRSTLLQIINARK-KSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
             F    I GP P  +FGNL+EYR   F+    +  RKYGK++ +FEG    + I D  +++ +LVK+ ++ F  R+ F      + +   ++F  + + WKR+R+ ++P+F+  +++ M  +I+   + L+  L E+S K+ E + + +V    +MD+I    F ++ +   N +DPF+ ++K  L    FS L + L   FP      I ++E+    I  +   +F  +  +L +I   RK K+ + R D+LQL++DS+   ++  +E        MK                  K LT  E++  + +F+FAGY+TSS  +S+  +++A N +   KL  EID+ F             YD+++ + YL+A + E++R +P V+  + R+C   + T   NG  IP+ T+I++ V  +H D + W   DP  F PERF + N +        +P +++PFG GPRNCIG R A + +KL +  ++ +F +      + PL+L     + P + + L    R
Sbjct:   32 FFVNLGIPGPKPLPVFGNLLEYRKG-FHVFDMECYRKYGKIWGFFEGRDRVLCIVDKSIVKSILVKECYTYFTNRRDFGL----NGELYDALFITKDEDWKRIRNHLSPSFTSGRLKEMFGIIQTHANTLVKNL-EKSSKNTEGVAVKEVFGAYSMDVITSTAFSVDIDSMNNPDDPFVTNIKKLLDFDVFSPLFL-LAGLFP----FLIPLLEKMKFSIFPAAVADFFFV--SLKKIKAERKAKNHKSRVDILQLMVDSQTEGEQQGEE--------MK------------------KGLTDHEILSQSMIFIFAGYETSSSTLSFFFYNIATNPETMKKLQQEIDQTFPNNAPVQ------YDAVMNMEYLDAALNESMRLFPSVAR-LERVC---KETIEINGLTIPQGTSIMIPVFPLHRDPEYW--PDPSTFNPERFTKGNKEN------IDPYVYMPFGSGPRNCIGMRFAQLAMKLAIVEILQRFNVINPDPDQVPLKLGTNIFLAPKDPIKLKFPPR 499          

Query:  155 FSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFN-SGISQKINFLKIRSTLLQIINARK-KSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNL 1699
            F +  I GP P  +FG ++EYR   F+    +  RKYGK++  F+G  P + I D  +++ +LVK+ ++ F  R+        + +   ++F  + + WKR+R+ ++P+F+  +++ M  +++   + L+  L E+S+K+ E I + DV    +MD+I    F ++ +   N  DPF+ ++K  L   +F S    + + FP      + ++E+   S  SQ ++   + S L +I   R+ K+ + R D+LQL++DS+  D +  +E        MK                  K L+  E++  +  F+FAGY+TSS  +S+  +++A N +   KL  EID+ F      N      YD+++ + YL A + E++R +P V+  + R+C   + T   NG  IP+ T+I++ V  +H D + W   DP  F PERF + N +        +P +++PFG GPRNCIG R AL+ +KL +  ++ +F +      + PL+L +   + P   + L
Sbjct:   33 FVKLGIPGPKPLPLFGTMLEYRKG-FHAFDMECYRKYGKIWGIFDGREPVLSIADQTIVKSILVKECYTYFTNRR----DVGLNGELYDALFVTKDEDWKRIRNHLSPSFTSGRLKEMFGIMKTHTNTLVKNL-EKSRKN-EGIAVKDVFGAYSMDVITSTAFSVDIDSMNNPKDPFVTNIKKMLD-IDFLSPIFIVAMVFP----FALPLLEKMKISFFSQSVSDFFLGS-LKKIKTEREAKNHKSRVDILQLMVDSQTEDDQQGEE--------MK------------------KGLSDHEILSQSMSFIFAGYETSSSTLSFFFYNIATNPETMKKLQREIDQTFPNKTPVN------YDAVMNMEYLEAALNESMRLFPVVAR-LERVC---KETIEINGLTIPQGTSIMIPVFPLHRDPEYWS--DPSTFNPERFTKGNKEN------VDPYVYMPFGSGPRNCIGMRFALLAMKLAIVEILQRFDVINPDPNQVPLKLGIHPFLSPKYPIKL 493          

Query:  149 SLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKK--SSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEK--------EIKTNIP-----MPK--MNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            S+  +  I  P P   FGN++ +R   F++       +YG+V  Y+ G  P VV+ DPD+L+ V+VK+F  F  R        P  +   S+   R +RWKR+RS + P+FS +KM+ M+PLI  + + L+  L    + + ES E  D+ +                +C L    PF++   +F+                 E+   FI                    S + +II  R +   +++R D LQL+LD   + + +    ++E+ +++   DE+        E   N P      PK     + +T +E++G A LF+ AGY+TSS  +++  + LA+N D Q KL  E+D+ F      +      Y ++ +L YL+ V+ E LR YP       R     E   + NGQ++PK   + ++   +H D   W   +P  F PERF        E  A  +P ++LPFG GPR+C+G RLA + I++ L ++  +F +   ++T+ PLQLK  TT+ P NG+ + I +R
Sbjct:   15 SVLQRCGIRHPKPIPFFGNMMLFRHG-FFDAHRDLINQYGRVCGYYLGRRPVVVVADPDMLRQVMVKEFQKFPNRMKLRAATKPMTE---SVLMLRNERWKRVRSILTPSFSAAKMKEMVPLINTATETLLNNL----KSYAESGESFDIHR---------------YDCTLAF--PFLIRPLSFIIPNKSRD----------EMNGFFI--------------------SCIQKIIKQRDELPPNQRRRDFLQLMLDVRSSKECV----SLENFDVVNHADEQAEEQPQVAEEAANGPGSSGDAPKRPQQKRMMTEDEIVGQAFLFLLAGYETSSNTLAFACYLLAINPDCQEKLQREVDDFFTRHGSAD------YTNVQELKYLDMVVCEALRLYP----PGFRFARDVEEDCVINGQFLPKGATLDISAGFLHHDPQYWP--EPEKFIPERFTP------EAKASRHPFVYLPFGAGPRSCVGMRLAQLEIRMALVNIFKKFNVVACEDTKVPLQLKSSTTLGPKNGIFVKITKR 476          

Query:  149 SLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINF-------LKIRSTLLQIINARKKSSE--KRFDLLQLLLDSEVTDK-KMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERKI 1720
              F +  + GP P    G ++EY+   F     +  +KYGKV+  ++   P + I D ++L+ +L+K+ +S F  R+ F     P  D   ++       WKR+RS ++P+F+  +++ M  +++     L+  L + S++  E+ +I ++    +MD++    F ++ +   N +DPF+ ++K  L     + L +A+ L FP            F + + +K+NF       +      L+ I +++ SS+  KR D LQL++DS+ ++K +  D+ AI                           LT  E++  + +F+FAGY+T+S  +S+  +++A N +   KL  EID+ F             YD+++ + YL+A + E+LR YP  +  + R+C K   T   N   IP++T ++  V  +H D + W   +P  F PERF + N +        +P +++PFG GPRNCIG R AL+ IKL +  ++ +F +  S+ T+ PL+L +   + P + + L    RK+
Sbjct:   31 GFFQRIGVPGPKPLPFIGTMLEYKQG-FQNFDLECFKKYGKVWGIYDARQPVLCIMDREILKTILIKECYSLFTNRRNFRLN-GPLYD---AVSIIEDDDWKRIRSVLSPSFTSGRLKEMFGIMKTHSHTLVQNLGKTSKRG-EAADIKEIFGAYSMDVVTSTAFSVDIDSLNNPDDPFVTNIKKMLKFDFLNPLFVAVAL-FP------------FIAPVLEKMNFCFFPPAVMDFFYAALKKIKSQRVSSDNKKRVDFLQLMIDSQKSEKVEHHDKGAIHG-------------------------LTDHEILSQSMIFIFAGYETTSSTLSFFFYNIATNPETMKKLQQEIDQTFPNESLIQ------YDAVMNMDYLDAALSESLRLYPPAAR-LERVCKK---TVEINRLTIPQNTVVLAPVFPLHRDPEYWP--EPDTFKPERFTKGNKEN------IDPFVYMPFGSGPRNCIGMRFALVTIKLAIVEILQRFDVILSEETKVPLELGISGLLAPKDPIKLKFIPRKV 503          

Query:   95 SLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARG------KRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQL 1657
            SLV  + TL Y+Y       F +  I GP P   FG  + Y +  FY+   +  +KYGKV+  F+G  P +++ D ++++ ++VK  +S F  R+        + ++  +  FA G      ++WKR+R++++P F+  K++ + P+ E+  D  +  L + S      +++ DV    +MD++    F ++ +   N +DPF   +K F   + FS L + L+L           ++ +    +  K +     ++L ++ +     + KR D +QL++  +++D +       ESS+     +E+ IK            LT  E++  + +F+  GY+T+S  ++++L++LA N D  NKL  EIDE+F             YD+++KL YL  VI E++R +P  +  + R+C K   T   NG  IPKDT + +  + +H D  LW    P  F PERF   N          +P +++PFG GPRNC+G R ALMI+KL +  L+  F +   + T+ PLQL
Sbjct:   12 SLVVLVITLLYIYGVWPYGFFKKLGIPGPKPWPFFGTFLSY-TKGFYKFDTECYKKYGKVWGIFDGRLPILMVSDYEMIKSIMVKDCYSVFTNRR--------ETNKDLAGPFADGISIVKDEKWKRIRASVSPFFTSGKLKEIFPIAEKYGDRFIENLKKRSPDG--PVKVKDVFAPFSMDVVASASFSVDIDSINNPDDPFGAHIKKFFNFSFFSPLFLFLVLFPSAAG-----ILGKMGFSMFAKSDMEFFYTSLKKLKDQHNNMNHKRVDFMQLMIQGQISDHQA------ESSS-----EEQPIKG-----------LTDHEILSQSFIFMLGGYETTSTTLTFLLYNLATNPDCLNKLMKEIDEMFPHGAPVT------YDALMKLEYLEMVINESMRLFP-TAPRLERVCKK---TVELNGITIPKDTLVTIPAYVLHRDPQLW--ESPEEFRPERFSPENN--------IDPYLFMPFGLGPRNCVGMRFALMIMKLVVVKLLQNFNVETCKETQIPLQL 481          

Query:   86 IFISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMD------VMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKS---SEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGT 1669
            + ++L AF+ +  Y+    +I  F +  + GP P  + G    Y    F E  A+  RKYG+V+  ++G  P +++ D ++L+ +LVK    +F  R+ F     P +D    +  A  + WKR+R+ + PAFS  K+++M PLI++  +VL+  LHE  Q   + +++ D      ++  L  +      FG     ++  +DP   +LK ++    FS L  A++L FP      I  +ER    +  K         + Q+ N R+K     + R D LQ ++++++++          +SN                    ++ LT  E+   A LF+ AGYD +S +++++ + LA N D Q K+  EID +  + +  +      Y+++ ++ YL+ V+ ETLR Y   S+  +R+C K   T + N   IPK   + V +  +H+D   W   +PH F PERF +      E     +P  +LPFG GPRNCIG R ALM +K+ +  ++ ++       T  P Q    T
Sbjct:   12 LVLTLAAFILSAIYLLWPYQI--FKKMGVPGPTPFPLVGTFHHYLKG-FREFDAESFRKYGRVWGIYDGRVPVLMVTDTNMLKQILVKDCLESFTNRRKFGLS-GPIKD---VLLIAEDEHWKRIRNVLTPAFSGGKIKQMCPLIQRCAEVLVQNLHEPCQLE-QPVDLKDEKFGSGILDHLEFE---GEGFGEIVKQKVFPHDPVPKALK-YIFLCEFSPL-FAVILFFP----FLISPLERLGVTLFDKKAIHFFHKIVQQMKNKRQKGLNDMQGRVDFLQQMVNAQLSEN---------TSN-------------------GNEDLTDGELESQAVLFLMAGYDNTSTSITFLAYCLACNPDVQTKVQQEIDTILPDGKLPD------YETLKQMEYLDMVVCETLRMYS-SSSRTDRVCKK---TTVVNDLVIPKGVVVTVPLWVLHYDPQYW--DEPHEFRPERFTK------EAKEARDPYCYLPFGHGPRNCIGMRFALMSVKIAVCRILQRYSFQTCSETTIPPQFNKNT 486          

Query:   77 VMFIFISLVAFLF---TLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ----FSNFHGRKL-FPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGG----TNFSSLKMALLLT--------FPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERK 1717
            + FI    +  LF    + + YR     +F +  + GP P    G  + Y    F E      +KYG+++  ++G  P +V+ D  +L+ VLVK     F+N     L  PF        K +M  A  ++WKR+R+ ++P FS  K+++M PLI +  D L+  L E+ Q    S +++D+ +             +  +C+L ++ P   SL A +G     T+ +S +M L  T        FPE+     ++   F    +       +R + + I    KK+++ R D LQL++D +++  K +   A   S+                     K LT  E+   A LF+ AGY+T+S A++++ + LA N D Q K+  EID         +      Y+ + ++ YL+ V+ ETLR YP  S   +R+C K   T + N   IPK   + V +  +H+D   W   +P  F PERF +      E     +P  +LPFG GPRNCIG R ALM +K+ +  ++ ++       T  P +L     +   N + + + ERK
Sbjct:    4 ITFILPCKITDLFYPSAMLWPYR-----IFKKMGVPGPTPLPFLGTFLHYHQG-FKEFDQNSFKKYGRIWGTYDGRLPLLVVADTSILKTVLVKDSLEFFTNRRNIGLNGPF--------KEAMSIANDEKWKRIRNVLSPTFSGGKIKQMCPLIVRCADSLVKNLREKCQ----SGKLVDLKE-------------LHVSCKLRISLP--KSLCALIGKYGNFTSDTSRQMVLCFTGINLTTPIFPELVPPLEFLGLSFFPKKASSFFTTIVRQSDVNI----KKNNKGRVDFLQLMVDVQLS--KSMQNGANPHSD---------------------KYLTDSELEAQAILFLLAGYETTSTAITFVAYCLACNPDVQTKVQQEIDRFLPNDTLPS------YEILKQMEYLDMVVSETLRMYPPTSRT-DRVCKK---TTVVNDLVIPKGVVVTVPLWVLHYDPQYW--DEPEEFRPERFSK------EAKEARDPYCYLPFGQGPRNCIGMRFALMSMKIVVCRILQRYSFHACNETTIPPKLTKNPFLQLENPLLVQVSERK 492          

Query:   77 VMFIFISLVAFLFT-LFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNF--HGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGIS---QKIN-FLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERK 1717
            V+++  S +   F+ L + YR     +F +  + GP P  +FG  + Y S  F     +  ++YG+V+  ++G  P +++ D ++L+ +LVK    F  + RK+       +E     +     ++WKR+R+ ++P FS  K+++M PLI +  DVL+  LHE+ Q   +S+++        ++      + I          P ++S    +    ++  + +L   FP    +F YM      G+S   +KI  F K      +   +   S++ R D LQL++D+++++      N                         + K LT  E+   A LF+ AG++T+S A++++ + LA N D Q K+  EIDE   + +  +      Y+ + ++ YL+ V+ ET+R YP  +  ++R+C +   T   +   IPKD  I V+   +H+D   W   +P+ F PERF +      E     +P  +LPFG GPRNCIG R ALM +K+ +  ++ ++       T  P +L  G+ +     + L + ERK
Sbjct:   11 VLYLLDSKINVSFSYLLWPYR-----IFKKMGVPGPTPLPLFGTFLHY-SKGFRAFDEESFQRYGRVWGIYDGRLPVLMVADTNMLKQILVKDCLEFFTNHRKI-----GLNELFGEGLSTVDDEQWKRIRNILSPTFSSGKIKQMYPLILRCADVLVKNLHEKCQSG-KSVDLKQGNGEWRLETNRVTAYKIFIALVKRPPPPLLLSRSKMININIYNVQRFSLSALFPVFVPLFEYM------GLSLFPKKICIFFKNIVQQFKTDISMNYSTKGRVDFLQLMVDAQLSETVQNGANP-----------------------HSEKYLTDSELEAQAILFLLAGFETTSTAITFVAYCLACNPDVQTKVQQEIDEFLPDDKAPS------YEILNEMEYLDMVVSETMRMYPPAAR-LDRVCKR---TTTVDNLVIPKDVVITVSTWVLHYDPQHW--EEPNEFRPERFTK------EAKEARDPYCYLPFGQGPRNCIGMRFALMSVKIAVCRILQRYSFQMCSETTIPPKLAKGSILQTEKPLLLKVSERK 505          

Query:  437 GKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMM----ERFNS--GISQKI--NFLKIRSTLLQIINARKKSSEKR-FDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPL 1651
            G +W R R  + P F    ++  + +I QS   ++ K    ++K   ++E+   +  L +  I KC F  E NCQ    + ++ ++       +      AL        + ++Y +     RF    G + K   + ++ R   L++   + K+ +KR  D L +LL S   D                                  + L+ EE+       +FAG+DT++  +S++LH+LA N   Q     E   V     +        +D I  LPY   VI E+LR YP V +I+ ++   ++   L +G  +P    + V++  +H +++ W   DP +F P RF Q N       A  +P  ++PF  GPRNCI +  AL  +++T++ ++ +FRI  +     PL
Sbjct:  127 GPKWFRNRRLLTPGFHYEILKPYIAIIGQSTASMLDKWERLTEKQ-PTLEVFGDISLLMLHSILKCAFSYEGNCQTEAGNSYVRAVYELTDLVHRRFRNFAL-------HNKWVYYLTPAGRRFQKAKGHAHKHTEDVIRRRRETLKLEAQQDKTQQKRNLDFLDILLSSRDAD---------------------------------GQSLSDEEIRTEVDTIMFAGHDTTASGLSWVLHALASNPHHQEVCRDEAARVLAGRSQPE------WDDISNLPYTTMVIKESLRLYPPVPSIIRKL---TQPLKLPHGHVLPAGMRVCVSIFCIHRNEEFWK--DPEVFDPLRFSQENS------AHRHPYAFIPFSAGPRNCIDQNFALNELRVTVAMILSRFRIHSASPPAWPL 482          

Query:  866 RKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERF---LQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            RK     R D LQ ++D++++D  M +   I                 IP      K LT  E++  A +F+ AGY+T+++ ++YI ++LAV+ D Q+KL  EID                Y   + LP+   V+ E+LR YP    +     +  E      G  +PK T I + V  +H   + W   DP  F PERF    +   D+Y          +LPFG GPRNCIG R AL+ +K+ +  L+ +F       T+ P ++ +   + P   + L   ER
Sbjct:   39 RKGEHTDRVDFLQTMVDAQISDSVMDEHGGI-----------------IPY-----KALTDSEILSQAMVFLLAGYETTAVTLTYIAYNLAVHVDVQDKLLEEIDATLPPEAP--------YCYRILLPH---VVSESLRLYPPAGRLERIAKMDVE----LGGIPVPKGTVIGIPVFVIHRHSEHWD--DPTAFRPERFSKEAREQRDQY---------CYLPFGAGPRNCIGMRFALINVKIAIVSLLRRFTFVTCPETKIPAEIGIRGLLEPKEPIILKFAER 276          

Query:  260 KYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ--FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPA---FSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPF---IVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLL---DSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLA-VNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERF-LQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPAN 1687
            KYG V  +F G   N+++   + L  +   +  F+    +K  P+          ++  A G  W+  R+ +      F D+        I ++  +L T +     +   SI +  + QR+ +D I +   G +     +  + F   ++ +K          +     LTFP                      FL +       I +RKK+ +      +LL+     E+ +    ++    +S+L++  + + I         + KQLT   VI      + AG++   +  +  L+ LA  + + Q KL  E++ +                 +  LP LNA ++E +R YP +STI+NR   K+    L     IPK   +  N      D   WG      F PER+   I      +    N      F GG R C+G++LAL  ++++L+ ++ QFR   S + E   +L     +CP N
Sbjct:   65 KYGAVKFFF-GSRWNILVSRSEYLAQIFKDEDTFAKSGNQKKIPYSALAAYTGD-NVISAYGAVWRNYRNAVTNGLQHFDDAP-------IFKNAKILCTLIKNRLLEGQTSIPMGPLSQRMALDNISQVALGFDFGALTHEKNAFHEHLIRIK--------KQIFHPFFLTFP----------------------FLDVLP-----IPSRKKAFKDVVSFRELLVKRVQDELVNNYKFEQTTFAASDLIRAHNNEII---------DYKQLTDNIVI-----ILVAGHENPQLLFNSSLYLLAKYSNEWQEKLRKEVNGITDP------------KGLADLPLLNAFLFEVVRMYPPLSTIINRCTTKT--CKLGAEIVIPKGVYVGYNNFGTSHDPKTWGTTADD-FKPERWGSDIETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFRW--SLDPEWEEKLTPAGPLCPLN 478          

Query:  233 YELFAKWERKYGKVFVY-FEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSI-----DVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYM-MERFNS-GISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQY-IPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQIN------GDE--YEFVAPTNPLI--WLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFR 1618
            YE F + ++KYG +F +   G    V +G P   + V   + ++      +     P    K  ++     R    +  +  A +    +  +PLI + +     D    +L+E +     +I++M     +T+    + + G E   +L+               T+F+ L   L   F  I  +F  + +E +     +QK     I  T + +I  R+K             ++++ D+ +ID       +LMK    K           +  ++T +E+       +  G  TS+   ++IL  LA   D Q +L  E   V    +++       YD + ++P LN  I ETLR +  + ++  ++    +  H+ N  Y IP   +++V+    H  +D + P + H F   R+ + +      G+E  Y F A +  +   +LPFGGG   CIG+  A   + + +S  I   +
Sbjct:   77 YEFFEECQKKYGDIFSFVLLGRVMTVYLG-PKGHEFVFNAKLADVSAEAAYAHLTTPVFG-KGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTG---TIDVMVTQPEMTIFTASRSLLGKEMRAKLD---------------TDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQK----AISGTYMSLIKERRK-------------NNDIQDRDLID-------SLMKNSTYK-----------DGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELT-----YDLLQEMPLLNQTIKETLRMHHPLHSLFRKVM---KDMHVPNTSYVIPAGYHVLVSPGYTHL-RDEYFP-NAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLK 492          

Query: 1022 KMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRI-TPSQNTENPL--QLKLGTTICPANGVNLGIRER 1714
            ++  ++ T +E+      F+FA  D SS    ++   +A   D   K+  E   V        LN     D I K+ Y N VI ETLR+ P V  +M    +K +   +S     PK   +I  ++    D +++   +P  F PER+++  G +    A      WL FG GP  C+G+   +    +T + L+ +F + T   +T  PL  ++K+  TI P + + L  ++R
Sbjct:  315 RIYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNL----DLIEKMKYTNMVIKETLRYRPPV--LMVPYVVK-KNFPVSPNYTAPKGAMLIPTLYPALHDPEVY--ENPDEFIPERWVE--GSK----ASEAKKNWLVFGCGPHVCLGQTYVM----ITFAALLGKFALYTDFHHTVTPLSEKIKVFATIFPKDDLLLTFKKR 529          

Query:  242 FAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGR-KLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPE-IKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARK-KSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYP--FVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERK 1717
            FA++ R YG+V+  +   +P +VI DPD+L++VLVK+F +FH R   FP  +  D    + MFFA G+ W R+R+T++P FS  KM+ +LPL+  S D++M+KL + ++K  E   +  + Q LTMD I + VFGIE++ Q N +DP  V+ ++ L  + F  +  A++   P+ IK +F  +   F S   + +   +      ++I A+K + +  R D+L L+L++      MID+                            K++T  E+I    +F+ AGY+ ++ A+++I ++LA N D Q KL  EID V+ + ++        YD + +L YL+ V+ ETLR YP   ++  + + C+         G+   K   I+++V+S+H D +LW   +P  F PERF        E     NP  +LPF  GPRNC+G R +LM +KL L+ ++ ++    +QNT+ P  LK G+ +     + LG++ R+
Sbjct:   27 FAEYSRTYGRVYGLYLFGSPTIVINDPDILKEVLVKEFHSFHDRPAFFPMPEPFD----SMMFFAEGETWHRVRTTVSPIFSAHKMKMVLPLMNNSCDIMMSKLQQAAEKG-EPFNMYRMGQSLTMDFILRIVFGIESSVQHNYDDPAFVAARSALEASTFQKIAGAVVGMMPKPIKKMFSRV---FFSHTKELVEMTE------KVIAAKKTQENSTRKDILDLMLEA------MIDDET------------------------KKKRMTEAEIIAQCLIFMIAGYEGTNSALTFICYNLATNPDIQEKLQQEIDSVWTDADQVLS-----YDILNELSYLDMVVSETLRMYPPGMLTRAVTQDCV-------IQGRRFRKGNAILMDVYSLHHDPELWP--EPERFNPERFTA------EAKQSRNPCAYLPFSAGPRNCVGMRFSLMELKLALTRILKKYSFAVTQNTKIPPTLKAGSALTCGGEMMLGVKARE 459          

Query:  167 NILGPPPNFIFGNL-IEYRSTVFYELFAK--WERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKI--NFLKIRSTLLQIINARKKS-SEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
             I GP P    GNL I Y     ++ +A+    + YG++  Y+ G    +++ DP++ + +LVK+F  F  R +    + P  D+  ++   +   W+RLR TI P FS  K++++LPLI +S  +L+ KL E   K  +S++++    + TM+ I    FGI+   Q N ND F+ + +   GG    SL   L + FP ++ I   M+++   G   +   + + I     QII  R+++ S+ R DLL++LL +E TD     +N                            +L+ +E++     F+ AGY+T+S  M++  + LA+N D Q++L  EIDEV   + +        YD+++ + YL  V+ E LR YP       R C +S      NGQ+ PK   +++ V ++H D ++W   +P  F PERF        E     +P   LPFGGGPRNCIG R AL+  K+ L +++  +R+     TE P+QL+   TI P +G+ L I +R
Sbjct:   44 GIPGPKPWPFIGNLPILYEKK--HDTYAQEYLVKTYGRLCGYYMGTRAAILVADPEMAKQILVKEFDKFVNRPIVQSAQTPPTDK--TLLSLQDDDWRRLRHTITPTFSAVKLKQVLPLINESCRILVEKLGEAC-KDGKSVDVLRSYGKFTMETIVTTAFGIDCQTQTNPNDQFVPNAQRLFGG---QSLFRMLAVLFPYLQPIVSLMVKQLGLGKQTETGKSAMFIVDAARQIIKHRRETGSQGRKDLLEILLSAETTDDDGRRKN----------------------------KLSDDEIVAQCFTFILAGYETTSNTMAFTSYLLALNPDKQDRLIEEIDEVAATVGDNFD-----YDTVLGMEYLEMVVQEALRLYP-PGFRFGRTCNQS---CTINGQFFPKGCIVLIPVFAMHRDPEIW--PEPEKFQPERFTA------EAKQARHPYAHLPFGGGPRNCIGMRFALLEAKMALVYILRYYRLERCPETEVPVQLQGTITISPKHGIYLKITKR 512          

Query:  167 NILGPPPNFIFGNLIEY-RSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEI-KSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGI 1705
            NI GP P    GNL +  R    +    +  ++YGKVF +  G TP +V+GDP++L+ V+VK+F NF  R  F   ++   +    MF A   +WKR+RST+ P F+  K+R+M P I +S D LM K+ + +    ES++I+ +  ++T+++I    FGI++  Q N N+ F    K       F  L+M L+L F  +   IF +++   N+ +   I+  K      +I++ R   +  R D + L+L +   D                                 S++L+  E+I  +  F+ AG++TSS A+S   + LA+N + Q +L  EI      +  +  +    ++    L YL+ V+ E LR +P V T MNR C ++    + NG  IP   ++ +  +S+H D D W   +P  F PERF    G   E     +P  ++PFG GPRNCIG R AL  +KL L  ++ +++   S +T+ PL L  G T+ P +G+ L I
Sbjct:   43 NIPGPTPLPYIGNLRDIQRLGGIHVAPVRLMQEYGKVFAWSVGRTPAIVVGDPEILKHVMVKEFQNFRNR--FLLFRDTRSEMLHGMFSATDDKWKRIRSTLTPTFTSGKLRQMNPKIRESCDTLMDKIGKVADTG-ESVDILGMFCQMTLEVILSTAFGIDSEVQKNPNNTFSDKAKEIFKSPTF--LRMFLMLPFASVFFKIFRFLIH--NNNMKYFIDLSK------EILSKRHDKTFNRKDFVDLMLSAVNPD--------------------------------GSRKLSDPEIIAQSVTFLLAGHETSSNALSATAYYLALNPEVQERLRLEI-----RMAAETNSDKSPHELANDLEYLDCVVNEVLRLHPPVHT-MNRECAQA---CVINGITIPAGMDVTIPFYSLHHDPDAWP--EPDKFDPERF---RGPAKE---SRHPFQFIPFGAGPRNCIGMRFALNEVKLVLFQILSKYKFVRSPDTQVPLVLIPGATLIPRDGIYLRI 495          

Query:  149 SLFSQYNILGPPPNFIFGNL-IEYRSTVFYELFAK--WERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRK----LFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKI--NFLKIRSTLLQIINARKKSSEK----------------RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            S      I GP P    GNL I ++    ++ +A+    + YG++  Y+ G   ++++ DP++ Q +LVK+F  F  R     L P   +    +K ++   +   W+RLR  + P FS  K+++++PLI +S  +L+ +L +   K  +S+++     + TM+ I    FGI+   Q N ND F+ + + + G  +  ++   L + FP ++ I   M+ R   G   +I  + + I     QII  R+++  K                + DLL++LL +E TD                 +D K              +L+ +E++     F+ AG+  +S  M++  + LA+N D Q++L  EID+V   + +        YD+++ + YL+ V+ E LR YP     + R C +S      NGQ+ PK   +++ V+++H D ++W   +P  F PERF        E     +P  +LPFG GPRNCIG R AL+ +K+ L +++  +R+     TE PLQL+   ++ P +G++L I +R
Sbjct:    5 SFLKNLGIPGPKPWPFIGNLPILFKKK--HDTYAQEYLVKTYGRLCGYYRGTRASILVADPEMAQQILVKEFDKFVNRGVSEGLLPLSSHIPPTDK-NLISLQDDDWRRLRHFVTPTFSAVKIKQVVPLISESCRILVEQLGQAC-KDGKSVDVCRTYVKFTMETIVSTAFGIDCQTQTNPNDQFLSNAQRYFGKPSPFTI---LAVLFPYLQPIISVMVRRLGLGRQTEIGKSVMFIVDAARQIIKHRRETGSKGVKYLHFPQGEPSGPRKKDLLEILLSAETTD-----------------DDGK-----------RKNKLSDDEIVAQCFTFILAGFQNTSNTMAFTSYLLALNPDKQDRLIEEIDDVAATVGDNFD-----YDTVLGMEYLDMVVQEALRLYP-PGFRLGRTCNQSCTI---NGQFFPKGCLVMIPVYAIHRDPEIW--PEPEKFQPERFTA------EAKQARHPYAYLPFGEGPRNCIGMRFALLKVKMALVYILRHYRLERCPETEVPLQLQGFISMSPKHGMHLRITKR 499          

Query:  242 FAKWERKYGKVFVYF-EGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGK--RWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQI--INARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYP--FVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQF 1615
            F ++ +KYG+++  F  G  P+V++GDPD++++++VK+FS+F  R + PF            F  R K  +W R+R++++PAFS  KM+ M+PLI  S DVL+ KL + +     S  +    Q LTMD I K  FGI +  Q N +DP   + +  +  +    + + L+   P  K IF +        I    + +KI + ++++  +N  K++     D+L L+L +        +EN                          SK+L+  EV+  + +F+ AGY+T+++ +S++ +SLA N D Q KL  EID V+ E ++        YD++  LPYL+ VI ETLR YP  FV++   R C +     +  G    K  +I ++ +S+H D + W   DP  F PERF +      E     +P  +LPFG GP NCIG R A M IKL L  ++ +F
Sbjct:   74 FQEYYKKYGRLYAMFLVGKKPSVIVGDPDIVKNIMVKEFSSFQDRPVEPFNS----------FMTRAKYDKWHRIRTSLSPAFSAHKMKLMVPLINSSCDVLINKLTKIADSG-TSFFVHKFHQGLTMDTILKTAFGIHSEAQTNYDDPAFTAARKSMSTSPARRVMLFLIFLMPFRKYIFRWFPSLL---IGNFDDIMKITTKMIEVKKVNPHKEAK----DMLDLMLSAAA------NEN-------------------------TSKKLSDMEVLAQSLIFLIAGYETTNITLSFVAYSLATNPDVQEKLQREIDSVWTEEDQMPS-----YDTVHNLPYLDMVISETLRLYPPGFVAS---RECTQD---CVIKGYRFRKGLSIFIDAYSMHHDPEFWT--DPERFDPERFSR------ECKQSRDPYSYLPFGHGPHNCIGMRFAQMEIKLALVRVLRKF 470          

Query:  125 YVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRL---TMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERF--NSGISQKINFLKIRSTLLQIINARKKS--SEKRFDLLQLLLDSEVTDKKMIDENAIESSN----------LMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERK 1717
            Y Y     S+ S+Y I  P P   FGNL  +R   F++      + +G+V  Y+ G  P VVI DPDLL+ V+VK FS+F  R    F   P  D    +   + +RW+R+RS + P+FS +KM+ M+PLI    +VLM  L      H ES +  D+ +     TMD+I    F  + + Q   +DPF+   + F   + F  + M   + FP +    +  + RF  N    +  NF      + +II  R++    ++R D LQL+LD+  T K+    +  ++SN              + E        + +   K +T +EV+G A +F+ AGY+T+S  + +  + LAV+ + Q+K+  E+D+ F   E  +      Y +I +L Y++ V+ ETLR YP       R   + E   + NG  +PK   + +    +H+D + W   +P  F PERF        E  A  +P ++LPFG GPRNC+G RLA + IK+ L+HL   F +     T+ PL+LK  +T+ P NG+ + I +R+
Sbjct:   33 YWYSVYPFSVLSRYGIKHPKPVPFFGNLFLFREG-FFKPLNDLIKTHGRVCGYYLGRKPVVVIADPDLLRQVMVKDFSSFPNRMTLRFATKPMVD---CLLALKDERWRRVRSILTPSFSAAKMKEMVPLINTVTEVLMKNL----TTHAESGQAFDIHRCFGFFTMDVIASVAFATQVDSQNKPDDPFVHHAQMFFTFSFFRPM-MMFFIAFPSL----MAPVARFIPNKRRDEMSNFFI--HNIQKIIKQREEQPPDQRRRDFLQLMLDAR-TAKECASLDQFDTSNHGDETLTNPKAASSDQESSRSEESALRRPQKKMMTEDEVVGQAFIFLLAGYETTSSTLGFTCYLLAVHPECQHKVQQEVDQFFSRHESPD------YTNIQELKYMDMVVSETLRLYP----PGFRFAREVEEDCVVNGVRLPKGATLEIPAGFLHYDPEYWS--EPEKFIPERFTA------EAKASRHPFVYLPFGSGPRNCVGMRLAQLEIKMALAHLFRSFSVVACSETKVPLELKSSSTLGPKNGIFVKITKRE 546          

Query:   98 LVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRS--TVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEK-RFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            LVAF+ TL  VY       F +  I GP P   FG ++ YR    +F E   +  +KYGK +  ++G  P + I DP  ++ VLVK+ +S F  R+ F     P  D   S+F A   +WKR+RS ++P+F+  +++ M  +++     L+  + +++ K  E + + D     +MD++    F ++ +   N +DPF+ ++K  L   +F +    L+  FP +  I    ME+          F    S L +I +  K + +K R D LQL++DS+  ++  + +                            K L+  E++  A +F+FAGY+T+S +++++ ++LA N +   KL  EID  F             Y  ++++ YL++V+ E+LR YP    I  R+   ++ T   NG  IPKD  ++V    +  D +LW   +P  F PERF + N + ++      P  ++PFG GPRNCIG R AL+ +KL L  ++ Q+  +  + TE P +L +   I P   + L +  R
Sbjct:   15 LVAFI-TLLLVYAYWPYGTFKRLGIPGPKPVPFFGTMLAYRKGFPIFDE---ECRKKYGKTWGIYDGRQPVLCITDPATIKAVLVKECYSLFTNRRNFHLN-GPMYD---SVFNAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLVNSMKKKADKD-EPLNLKDHFGPYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLK-FDFLNPLFLLVAFFPFLGPI----MEKMELSFFPASAFDFFYSALQKIKSDHKNNKQKSRIDFLQLMIDSQKNNQNGLQD----------------------------KGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKAPIQ------YAPLLEMEYLDSVVNESLRLYP----IAARLERVAKATVEVNGLVIPKDMVVMVPTWPIQRDPELWP--EPEKFKPERFSKENKETFD------PYTYMPFGAGPRNCIGMRFALVSMKLALVEILQQYSFSVCKETEIPFELDIQGLIAPKRPIFLKLVPR 497          

Query:   98 LVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGI--SQKINFL--KIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            LVAF+ TL  VY       F +  I GP P   FG ++ YR   F+    +  +KYGK +  ++G  P + I DP  ++ VLVK+ +S F  R+ F     P  D   ++  A   +WKR+RS ++P+F+  +++ M  +++     L+  + ++  K  E +E+ +     +MD++    F ++ +   N +DPF+ ++K  L     + L +A+   FP +  I    +E+F   +  S  ++F    +R       N ++KS   R D LQL++DS+  ++  + +                            K L+  E++  A +F+FAGY+T+S +++++ ++LA N +   KL  EID  F             Y  ++++ YL+ V+ E+LR YP    I  R+   ++ T   NG  IPKD  ++V    +H D +LW   +P  F PERF + N D ++      P  ++PFG GPRNCIG R AL+++KL +  ++  +  +  + TE P +LK+G  + P   + L +  R
Sbjct:   15 LVAFI-TLLLVYAYWPYGTFKRLGIPGPKPVPFFGTMLAYRKG-FFNFDEECRKKYGKTWGIYDGRQPVLCITDPATIKAVLVKECYSLFTNRRNFRLN-GPLYD---AVSIAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLIQSMKKKVDKD-EPLEMKEYFGPYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAF-FPFLGPI----LEKFEFSLFPSSVMDFFFAALRKIKANHENNKQKS---RIDFLQLMIDSQKNNQNGLQD----------------------------KGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKAPVQ------YVPLMEMEYLDCVVNESLRLYP----IAARLERVAKATVEVNGLVIPKDMVVMVPTWPLHRDPELW--PEPEKFKPERFSKENKDTFD------PYTYMPFGAGPRNCIGMRFALVMMKLAVVEILQTYDFSVCKETEFPFELKMG-FLAPKRPIQLKLTPR 496          

Query:   98 LVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGI--SQKINFL--KIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            LVAF+ TL  VY       F +  I GP P   FG ++ YR   F+    +  +KYGK +  ++G  P + I DP  ++ VLVK+ +S F  R+ F     P  D   ++  A   +WKR+RS ++P+F+  +++ M  +++     L+  + ++  K  E +E+ +     +MD++    F ++ +   N +DPF+ ++K  L     + L +A+   FP +  I    +E+F   +  S  ++F    +R       N ++KS   R D LQL++DS+  ++  + +                            K L+  E++  A +F+FAGY+T+S +++++ ++LA N +   KL  EID  F             Y  ++++ YL+ V+ E+LR YP    I  R+   ++ T   NG  IPKD  ++V    +H D +LW   +P  F PERF + N D ++      P  ++PFG GPRNCIG R AL+++KL +  ++  +  +  + TE P ++ +   + P   + L +  R
Sbjct:   15 LVAFI-TLLLVYAYWPYGTFKRLGIPGPKPVPFFGTMLAYRKG-FFNFDEECRKKYGKTWGIYDGRQPVLCITDPATIKAVLVKECYSLFTNRRNFRLN-GPLYD---AVSIAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLIQSMKKKVDKD-EPLEMKEYFGPYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAF-FPFLGPI----LEKFEFSLFPSSVMDFFFAALRKIKANHENNKQKS---RIDFLQLMIDSQKNNQNGLQD----------------------------KGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKAPVQ------YVPLMEMEYLDCVVNESLRLYP----IAARLERVAKATVEVNGLVIPKDMVVMVPTWPLHRDPELW--PEPEKFKPERFSKENKDTFD------PYTYMPFGAGPRNCIGMRFALVMMKLAVVEILQTYDFSVCKETEVPFEMDVQGFLAPKRPIQLKLTPR 497          

Query:   95 SLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQ-FSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIF-IYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQ 1654
            +L+A +FT+  ++      +F    I GP P    GNL++ +   F+E   + + KYG V+  FEG  P +++ DP++++ V+VK+ +S F  R+ F     P  +  AS   A+ ++WKR+RS+++P F+  +++++  ++ +  D L+ KL E      ++I+I   +   T+D++    F ++ +C  N +DP  V  +     T F+ L   L    P    +  ++ +E   S      N       +  + +  K     R D LQ+L++SE+ D                     EIK +   P   SK LT  E++  A  F+  GYDT+S A+SYI + LA N DA + L  EID   ++    +      Y+ +  L YL+ VI E+LR YP V+  ++R C   + T  + G  +P+   + + V+ +H D   W    P +F PERF + N  E       NP  ++PFG GPRNC+G R A++++K+ +  L+ ++ +   + T  P+Q
Sbjct:   28 TLLALIFTILLLFGIWPFRIFQNMGISGPMPMPYVGNLLQ-QGKGFFEFDHECQTKYGDVWGVFEGRQPILMVADPEIIKTVMVKECYSAFTNRRNFFEGDGPLTEAVAS---AKDEKWKRIRSSLSPCFTSGRLKQVFSIVSRYADRLVEKLGETYLN--KAIDIRQFVAPYTLDVVASASFSVDPDCINNPDDPINVQAQK---ATRFNFLPTILQSIIPFGGRLLKLFKIETLPSA-----NVEFFIDIIRNLKDQHKTGKMNRPDFLQVLIESEMPDA--------------------EIKNSQQQP---SKGLTETEILSQALGFIVGGYDTTSTALSYIFYCLATNTDAMHTLQKEIDSNLQKNSSIS------YEDLNGLEYLDQVINESLRLYP-VAPRLDREC---KMTVETQGFTVPEGMIVGIPVYLLHKDPRFWS--SPELFRPERFSKENEGEL------NPYAYMPFGLGPRNCVGMRFAVLMMKMIIVRLLQRYSVETCKYTLIPMQ 494          

Query:   80 MFIFISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERKI 1720
            MFIFISLV FLFTLFYVYRRRKISLFSQYNI GPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSI+VLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFKELEEKNLNSLEFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERKI
Sbjct:    1 MFIFISLVVFLFTLFYVYRRRKISLFSQYNIRGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSINVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFKELEEKNLNSLEFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRERKI 547          

Query:   80 MFIFISLVAFLFTLFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDE------------NAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYIPKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            M IF+SL+    +LFY YRRR+ + F++YNI GPPPNF+FGNLIEYR+  FYEL  KW++++GKVFVYFEGPTPNVVIGDPDLLQ+V+VKQFSNFHGRKLFP QKNPDEDEK SMF ARGKRWKRLR+TINPAFSD+KMRRM P++++SI   + KL+E   K  + I I + +QRLTMDIICKC FG++T+CQ N+N PFIVSLK FL   N S+LK A++LT  EIK + +Y++E FN    Q++  +KIRSTL+Q+I AR+K SEKRFDLLQ+L+D+EV   K++DE            N  ES    +  DE+  +      K  SK LTTEEVI  A LF+FAGY+TSS A+S+ILHSL+V  D Q+KL  EI  + +++E+K++ S E YD++ +LPYLNA+IYETLRFYPF ST+++RMCLKSEGTHLSNG YIP+ T +I NV ++H+DKD+W   DPH F PERFLQ NG E EF+ P NP  WLPFG GPRNCIG+R A+M+I+ TL   +++F+++ ++ TENPL+LK+G TI P NGVN+ +++R
Sbjct:    1 MLIFVSLLLTFLSLFYFYRRRRFASFAKYNIPGPPPNFLFGNLIEYRNNTFYELLIKWQKEFGKVFVYFEGPTPNVVIGDPDLLQEVMVKQFSNFHGRKLFPMQKNPDEDEKVSMFLARGKRWKRLRTTINPAFSDAKMRRMFPMVDESIASFVNKLNERGDKKFDCINIQEYLQRLTMDIICKCAFGVDTDCQTNINHPFIVSLKKFLKEMNLSTLKAAVVLTLAEIKPVLVYLLEAFNQRPGQRVELMKIRSTLVQVIEARRKCSEKRFDLLQMLIDAEVPGTKILDEDNLCPMNDNTSLNQAESQTDEEKTDEEITEQTSSNQKKTSKPLTTEEVIAQANLFLFAGYETSSTALSFILHSLSVYPDVQDKLFQEISRLHEKIEDKSIGSRELYDALGRLPYLNALIYETLRFYPFASTVIHRMCLKSEGTHLSNGLYIPQGTFVIPNVFAIHYDKDIWTSVDPHTFSPERFLQSNGTELEFIGPPNPFAWLPFGAGPRNCIGQRFAMMVIRATLCQFVYRFQVSSTEKTENPLKLKVGATISPINGVNIVLKKR 557          

Query:   98 LVAFLFT-LFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYI--PKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERF----LQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            L+AF+   L Y + ++  +L  +    GPPP    GNL++ +   F+       +KYGK++  + G +P  V+GD +LL+ +++K+F  F  R    F+   D      +    GK W+R+R+ I P F+  K+R+M PLI   I++L  ++          I+I +    LTMD+I + +FG++ + Q N    F+++ K     + F+S  +  LL FP++  +F  ++ ++     +   F      +   I+ R KS++K  D L L++ +     K   EN  ESS L                 M+SK L+ +E++  + +F+ AGY+T++  ++++ + LA N DAQ  L +EI E      E         D+++ +P L+A++ E+LR  P  +  ++R+C +      S+   +   K   I + +++VH D  +W   DP  F   RF     + NG +Y F         +PFG GPRNC+G R AL+ +K  +  ++  F I P Q T   L  K+   + P + + L I +R
Sbjct:   15 LLAFVVVYLIYKFGKQNQNLHVKLGHNGPPPLPFLGNLLDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFRSKRDHKMLTDL---NGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPN--TPIDIKEFFGALTMDVIARTMFGLQIDSQTNPKSQFVINAKKLFTFSFFNSFVIIFLL-FPKLGILFRKILPKWEFFGKESFQFF--IDNMQMAIDERAKSTDKYNDFLALMMKAH----KKETENDSESSKL-----------------MDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIPN------DTLMTMPILDAIVCESLRICP-PAVRVDRVCTQDVTLETSDKTKVCFKKGDIIAIPIYAVHSDPSIW--PDPEKFDYHRFDPDHKKTNG-QYSF---------MPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLEKLTFKISVLLGPISPILLKIVKR 512          

Query:   98 LVAFLFT-LFYVYRRRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDSEVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYI--PKDTNIIVNVHSVHFDKDLW-GPH--DPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            L+AF+   L Y + ++  +L  +    GPPP    GNL++ +   F+       +KYGK++  + G +P  V+GD +LL+ +++K+F  F  R    F+    +     +   +GK W+R+R+ I P F+  K+R+M PLI   I++L  ++          I+I +    LTMD+I + +FG++ + Q N N+ F+++ K     + F+S  + + L FP++  +F  ++ ++     +   F      +   I+ R KS++K  D L L+        K   EN  ESS L                 M+SK L+ +E++  + +F+ AGY+T++  ++++ + LA N DAQ  L +EI E      E         D+++ +P L+A++ E+LR  P  +  ++R+C +      S+   +   K   I + +++VH D  +W  P   D H F P+R  + NG +Y F         +PFG GPRNC+G R AL+ +K  +  ++  F I P Q T   L  K+   + P + + L I +R
Sbjct:   15 LLAFVVVYLIYKFGKQNQNLHVKLGHNGPPPLPFLGNLLDVQKMGFHTFDKMCRQKYGKLYPMYFGGSPMTVVGDEELLKQIMIKEFKCFTDRMELAFR---SKRAHKMLTVLKGKDWERVRNLITPTFTSGKLRKMSPLISDGIELLKKRISNNPPD--TPIDIKEFFGALTMDVIARTMFGMQIDSQTNPNNQFVINAKRLFTFSLFNSF-VIIFLMFPKLGILFRKILPKWEFFGKESFQFF--IDNMQMAIDERAKSTDKYNDFLALM-----KAHKKETENDSESSKL-----------------MDSKTLSNDEIMAQSLVFLLAGYETTATTLAFVSYFLAKNPDAQQDLYNEIMECLGSEREIAN------DTLMTMPILDAIVCESLRICP-PAVRVDRVCTQDVTLETSDKTKVCFKKGDIIAIPIYAVHSDPSIWPDPEKFDYHRFDPDR-KKTNG-QYSF---------MPFGMGPRNCVGMRFALLEVKWAIVSILQNFEIVPCQETLEKLTFKISGLLSPISPILLKIVKR 511          

Query:   98 LVAFLFTLFYVYR--RRKISLFSQYNILGPPPNFIFGNLIEYRSTVFYELFAKWERKYGKVFVYFEGPTPNVVIGDPDLLQDVLVKQFSNFHGRKLFPFQKNPDEDEKASMFFARGKRWKRLRSTINPAFSDSKMRRMLPLIEQSIDVLMTKLHEESQKHIESIEIMDVMQRLTMDIICKCVFGIETNCQLNVNDPFIVSLKAFLGGTNFSSLKMALLLTFPEIKSIFIYMMERFNSGISQKINFLKIRSTLLQIINARKKSSEKRFDLLQLLLDS--EVTDKKMIDENAIESSNLMKFEDEKEIKTNIPMPKMNSKQLTTEEVIGTATLFVFAGYDTSSMAMSYILHSLAVNYDAQNKLTSEIDEVFXXXXXXXXXXXXFYDSIVKLPYLNAVIYETLRFYPFVSTIMNRMCLKSEGTHLSNGQYI--PKDTNIIVNVHSVHFDKDLWGPHDPHIFYPERFLQINGDEYEFVAPTNPLIWLPFGGGPRNCIGKRLALMIIKLTLSHLIHQFRITPSQNTENPLQLKLGTTICPANGVNLGIRER 1714
            L+     +F +Y+    K +L  +    GPPP   FGN  +      YEL      KYGK++ ++ G  P  ++ D +LL+ +L+K    F  R       N    +K  +   +GK W+R+R+ ++P F+  K+R+M PL++  ID+L  +L    +   + I++ DV   LTMD+I + +FG+  + Q N N+PFI++ K     + F+ + + L+L FPEI  IF      +     Q +NF    S L + ++ RKKS E+  D L  ++ +  EV D                  D ++++       ++S+ LT  E+I  + LF+ AGY+T++ +++Y+ + LA N +AQ ++  EI +VF   EE +      Y+ I  LP+L A I E+LR  P  S + +R+C +      S+ + I   K     V ++++H D ++W   +P+ F   RF      + E     +   ++PFG GPRNC+G R A++ +K+ L +L+ QF + P   T + ++ K      P   + L I +R
Sbjct:   10 LLLCFVVIFLIYKLGTLKQNLHKKLGHQGPPPLPFFGNFFDIIRHGLYELDIINRDKYGKIYPFYFGGIPISIVSDEELLKQILIKDAKCFTDR--LDIGSNGKIGQKM-LIILKGKSWERVRNLVSPTFTSGKLRKMSPLMKDCIDLLDKRLAGIPEN--DPIDVKDVFGALTMDMIARTMFGMHIDSQTNPNNPFIINAKKLFKFSLFNPM-LILILFFPEITPIFRKFFPNWEFLGRQTMNFF--VSNLNKAMDERKKSPEQYNDFLTEMMKAHKEVND-----------------SDPEQLEI------LDSRSLTNSEIIAQSFLFLLAGYETTATSLTYVAYFLAKNPEAQQEVYREIIKVFGTDEEIS------YEKISNLPFLEAAINESLRICPPASRV-DRVCTEDVVLVTSDNKQINAKKGDVFTVPIYAIHMDPEIW--PEPYKFDLSRF------DNESKKTRSIYSFMPFGMGPRNCVGMRFAVLEMKMALVNLLKQFELVPCAETLDVIKFKKTAFGGPVKPIILKIVKR 508