SH3 domain protein

Overview
NameSH3 domain protein
Smed IDSMED30016436
Length (bp)1905
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SH3 domain protein (SMED30016436) t-SNE clustered cells

Violin plots show distribution of expression levels for SH3 domain protein (SMED30016436) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SH3 domain protein (SMED30016436) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SH3 domain protein (SMED30016436) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30016436

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
posterior sideSMED30016436h1SMcG0012774 dd_Smed_v4_6830_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30016436h1SMcG0012774 dd_Smed_v4_6830_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
reproductive organSMED30016436h1SMcG0012774 Contig39611newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016436h1SMcG0012774 Contig39611uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016436h1SMcG0012774 Contig44125uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016436h1SMcG0012774 Contig44125newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016436h1SMcG0022925 Contig44125uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30016436h1SMcG0022925 Contig44125newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of SH3 domain protein vs. Ensembl Human
Match: NCKIPSD (NCK interacting protein with SH3 domain [Source:HGNC Symbol;Acc:HGNC:15486])

HSP 1 Score: 98.9821 bits (245), Expect = 7.159e-21
Identity = 105/427 (24.59%), Postives = 185/427 (43.33%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSG----DWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKNDD 1690
            +P  +   L +++R++T  SH+     + I++  ++ SVP        +   L+      +      SG    D   L  +F    +RK+D Q+RSW+L+ED   ++     LL IL   +  +     +   ++  L+L+  YQME R  LR LLL+ F   C ++   I   + S+LP+EL RD+     + +   Y++L+L ++ +  + +     E L   F   +L  + +     LD++                          + D+ V  LL+ N       +N I+ +L  K    ++F EKL+   NR  DP           I   +    +SV K L D+  S   A + Y  D   +IDI  R + +L        EYL L+  IV  + YL+  +++  DL++ L  + N++
Sbjct:  308 VPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMA---LPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVED--GLPLDTTEQ------------------------LPDLCVNLLLALNLHLPAADQNVIMAALS-KHANVKIFSEKLLLLLNRGDDPV---------RIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAIVRTTPYLQH-RHRLPDLQAILRRILNEE 694

HSP 2 Score: 56.9954 bits (136), Expect = 8.893e-8
Identity = 24/71 (33.80%), Postives = 43/71 (60.56%), Query Frame = 2 
Query:   47 LWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSE-KEGTLGCVPINYMKMIDMPEKKILKYIDKAI 256
            ++  LY++    P +L+F A E FLVL + + +W+L +  + G  G VP  Y++ +   E+ +L+ ID+AI
Sbjct:    1 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAI 71
[Close]
BLAST of SH3 domain protein vs. Ensembl Human
Match: NCKIPSD (NCK interacting protein with SH3 domain [Source:HGNC Symbol;Acc:HGNC:15486])

HSP 1 Score: 98.9821 bits (245), Expect = 7.201e-21
Identity = 105/427 (24.59%), Postives = 185/427 (43.33%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSG----DWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKNDD 1690
            +P  +   L +++R++T  SH+     + I++  ++ SVP        +   L+      +      SG    D   L  +F    +RK+D Q+RSW+L+ED   ++     LL IL   +  +     +   ++  L+L+  YQME R  LR LLL+ F   C ++   I   + S+LP+EL RD+     + +   Y++L+L ++ +  + +     E L   F   +L  + +     LD++                          + D+ V  LL+ N       +N I+ +L  K    ++F EKL+   NR  DP           I   +    +SV K L D+  S   A + Y  D   +IDI  R + +L        EYL L+  IV  + YL+  +++  DL++ L  + N++
Sbjct:  301 VPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMA---LPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVED--GLPLDTTEQ------------------------LPDLCVNLLLALNLHLPAADQNVIMAALS-KHANVKIFSEKLLLLLNRGDDPV---------RIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAIVRTTPYLQH-RHRLPDLQAILRRILNEE 687

HSP 2 Score: 56.9954 bits (136), Expect = 8.932e-8
Identity = 24/71 (33.80%), Postives = 43/71 (60.56%), Query Frame = 2 
Query:   47 LWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSE-KEGTLGCVPINYMKMIDMPEKKILKYIDKAI 256
            ++  LY++    P +L+F A E FLVL + + +W+L +  + G  G VP  Y++ +   E+ +L+ ID+AI
Sbjct:    1 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAI 71
[Close]
BLAST of SH3 domain protein vs. Ensembl Human
Match: NCKIPSD (NCK interacting protein with SH3 domain [Source:HGNC Symbol;Acc:HGNC:15486])

HSP 1 Score: 73.9442 bits (180), Expect = 5.841e-14
Identity = 61/228 (26.75%), Postives = 108/228 (47.37%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLE-KAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAML 1102
            +P  +   L +++R++T  SH+     + I++  ++ SVP        +   L+      +   +     D   L  +F    +RK+D Q+RSW+L+ED   ++     LL IL   +  +     +   ++  L+L+  YQME R  LR LLL+ F   C ++   I   + S+LP+EL RD+           +A  LL I+ +G   + +D  E+L  + CV +L
Sbjct:   44 VPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQEHLGTPFAQFLLNIVEDG---LPLDTTEQLP-DLCVNLL 267
[Close]
BLAST of SH3 domain protein vs. Ensembl Human
Match: NCKIPSD (NCK interacting protein with SH3 domain [Source:HGNC Symbol;Acc:HGNC:15486])

HSP 1 Score: 55.4546 bits (132), Expect = 1.750e-7
Identity = 24/71 (33.80%), Postives = 43/71 (60.56%), Query Frame = 2 
Query:   47 LWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSE-KEGTLGCVPINYMKMIDMPEKKILKYIDKAI 256
            ++  LY++    P +L+F A E FLVL + + +W+L +  + G  G VP  Y++ +   E+ +L+ ID+AI
Sbjct:    1 MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAI 71
[Close]
BLAST of SH3 domain protein vs. Ensembl Fly
Match: CG2258 (gene:FBgn0029997 transcript:FBtr0340140)

HSP 1 Score: 123.25 bits (308), Expect = 7.114e-29
Identity = 111/413 (26.88%), Postives = 191/413 (46.25%), Query Frame = 2 
Query:  440 FMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYN-------SGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDL 1657
            + + D +R++T  S   S + L+++L +L+      +++  +I N  L     H+             + D   L  LF      KND ++R+W L+ED  D+      L++IL   + S+    +    Y  F++L++ YQME R  +++LLL+ F   C ++   + I L S+LPLE+V D+     N   F     +LTI+ +    M ++ Q+ L V F   +L                              EI    +P  + D+++  +L+FN++F     N II  +Q  P   ++F EKL+   NR+ DP     + ++           N+V ++  DI S    A + Y ND  V+IDI+ R+L +L A ST    YL L   I+ N++Y E  +++ +DL
Sbjct:  402 YQIVDALRRNTNLSFDLSCEALRVVLTSLE------QLYNGAI-NPYLEAVAVHVTGKVATPKELLGITHDAKRLQYLFAQLADCKNDTEQRTWMLYEDEEDIIQFLEELVEILINADESISCYEMSCDQYQMFINLVQYYQMETRWSIKRLLLKTFTAACHLDYIIVDILLTSVLPLEIVEDMKTHFSNLDRFKQLVKMLTIIFSLGQPMPVNHQDYLGVHFASFLL------------------------------EIVEGNNPEVLVDMVIALILAFNQQFSEHTYNVIIEGMQNLPSA-KVFTEKLLLLLNREDDPTRLLKHPNE---------HMNTVLRMFIDIFSHPDTAGMFYTNDIKVLIDIVVRQLSDLDAGSTTRPCYLELCRRILRNTNYQEH-QHRKHDL 766
[Close]
BLAST of SH3 domain protein vs. Ensembl Fly
Match: CG2258 (gene:FBgn0029997 transcript:FBtr0071110)

HSP 1 Score: 123.25 bits (308), Expect = 7.114e-29
Identity = 111/413 (26.88%), Postives = 191/413 (46.25%), Query Frame = 2 
Query:  440 FMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYN-------SGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDL 1657
            + + D +R++T  S   S + L+++L +L+      +++  +I N  L     H+             + D   L  LF      KND ++R+W L+ED  D+      L++IL   + S+    +    Y  F++L++ YQME R  +++LLL+ F   C ++   + I L S+LPLE+V D+     N   F     +LTI+ +    M ++ Q+ L V F   +L                              EI    +P  + D+++  +L+FN++F     N II  +Q  P   ++F EKL+   NR+ DP     + ++           N+V ++  DI S    A + Y ND  V+IDI+ R+L +L A ST    YL L   I+ N++Y E  +++ +DL
Sbjct:  402 YQIVDALRRNTNLSFDLSCEALRVVLTSLE------QLYNGAI-NPYLEAVAVHVTGKVATPKELLGITHDAKRLQYLFAQLADCKNDTEQRTWMLYEDEEDIIQFLEELVEILINADESISCYEMSCDQYQMFINLVQYYQMETRWSIKRLLLKTFTAACHLDYIIVDILLTSVLPLEIVEDMKTHFSNLDRFKQLVKMLTIIFSLGQPMPVNHQDYLGVHFASFLL------------------------------EIVEGNNPEVLVDMVIALILAFNQQFSEHTYNVIIEGMQNLPSA-KVFTEKLLLLLNREDDPTRLLKHPNE---------HMNTVLRMFIDIFSHPDTAGMFYTNDIKVLIDIVVRQLSDLDAGSTTRPCYLELCRRILRNTNYQEH-QHRKHDL 766
[Close]
BLAST of SH3 domain protein vs. Ensembl Fly
Match: CG2258 (gene:FBgn0029997 transcript:FBtr0071111)

HSP 1 Score: 123.25 bits (308), Expect = 7.114e-29
Identity = 111/413 (26.88%), Postives = 191/413 (46.25%), Query Frame = 2 
Query:  440 FMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYN-------SGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDL 1657
            + + D +R++T  S   S + L+++L +L+      +++  +I N  L     H+             + D   L  LF      KND ++R+W L+ED  D+      L++IL   + S+    +    Y  F++L++ YQME R  +++LLL+ F   C ++   + I L S+LPLE+V D+     N   F     +LTI+ +    M ++ Q+ L V F   +L                              EI    +P  + D+++  +L+FN++F     N II  +Q  P   ++F EKL+   NR+ DP     + ++           N+V ++  DI S    A + Y ND  V+IDI+ R+L +L A ST    YL L   I+ N++Y E  +++ +DL
Sbjct:  402 YQIVDALRRNTNLSFDLSCEALRVVLTSLE------QLYNGAI-NPYLEAVAVHVTGKVATPKELLGITHDAKRLQYLFAQLADCKNDTEQRTWMLYEDEEDIIQFLEELVEILINADESISCYEMSCDQYQMFINLVQYYQMETRWSIKRLLLKTFTAACHLDYIIVDILLTSVLPLEIVEDMKTHFSNLDRFKQLVKMLTIIFSLGQPMPVNHQDYLGVHFASFLL------------------------------EIVEGNNPEVLVDMVIALILAFNQQFSEHTYNVIIEGMQNLPSA-KVFTEKLLLLLNREDDPTRLLKHPNE---------HMNTVLRMFIDIFSHPDTAGMFYTNDIKVLIDIVVRQLSDLDAGSTTRPCYLELCRRILRNTNYQEH-QHRKHDL 766
[Close]
BLAST of SH3 domain protein vs. Ensembl Fly
Match: CG2258 (gene:FBgn0029997 transcript:FBtr0071109)

HSP 1 Score: 123.25 bits (308), Expect = 7.114e-29
Identity = 111/413 (26.88%), Postives = 191/413 (46.25%), Query Frame = 2 
Query:  440 FMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYN-------SGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDL 1657
            + + D +R++T  S   S + L+++L +L+      +++  +I N  L     H+             + D   L  LF      KND ++R+W L+ED  D+      L++IL   + S+    +    Y  F++L++ YQME R  +++LLL+ F   C ++   + I L S+LPLE+V D+     N   F     +LTI+ +    M ++ Q+ L V F   +L                              EI    +P  + D+++  +L+FN++F     N II  +Q  P   ++F EKL+   NR+ DP     + ++           N+V ++  DI S    A + Y ND  V+IDI+ R+L +L A ST    YL L   I+ N++Y E  +++ +DL
Sbjct:  402 YQIVDALRRNTNLSFDLSCEALRVVLTSLE------QLYNGAI-NPYLEAVAVHVTGKVATPKELLGITHDAKRLQYLFAQLADCKNDTEQRTWMLYEDEEDIIQFLEELVEILINADESISCYEMSCDQYQMFINLVQYYQMETRWSIKRLLLKTFTAACHLDYIIVDILLTSVLPLEIVEDMKTHFSNLDRFKQLVKMLTIIFSLGQPMPVNHQDYLGVHFASFLL------------------------------EIVEGNNPEVLVDMVIALILAFNQQFSEHTYNVIIEGMQNLPSA-KVFTEKLLLLLNREDDPTRLLKHPNE---------HMNTVLRMFIDIFSHPDTAGMFYTNDIKVLIDIVVRQLSDLDAGSTTRPCYLELCRRILRNTNYQEH-QHRKHDL 766
[Close]
BLAST of SH3 domain protein vs. Ensembl Zebrafish
Match: nckipsd (NCK interacting protein with SH3 domain [Source:ZFIN;Acc:ZDB-GENE-130326-2])

HSP 1 Score: 114.39 bits (285), Expect = 5.767e-26
Identity = 110/443 (24.83%), Postives = 208/443 (46.95%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALN-ILKNDDINDFDKTLIDSILEKLDHT 1747
            +P  +   LT+++R++T  S + S   + +++  L+ ++P  ++    +   L  ++   L +  +   D   L  +F    + + D+Q+RSW+LHED   +      LL+IL   +  +         ++P LSL+  YQME R+ LR  LL++F   C ++   I   L S+L +EL RDL       +   Y++LL+ ++ +  + + +   E LN  F   +L  + +   T                  DS E         + D+ +  LL+FN        N ++ +L +K +  ++  EKL+   NR  DP    S+           ++ ++V K L D+ SS   A + YR+D  V+IDI  R++ +L       ++YL L+  ++  S+Y E  +++  DL++AL  IL  ++    +++++  I E+   T
Sbjct:  354 LPLTIGAELTELVRRNTGLSCELSRVAVGVVVGRLQGALPGAQVQLEQVLQSLALSTDLPLGQVCH---DQQRLQVIFGDLARHREDSQQRSWALHEDHALIACYLEELLQILTDADAEVCRKMCRVNEFEPVLSLVSYYQMEHRVSLRLWLLKVFGAMCGLDAALISTLLNSVLTMELARDLQTDTDEHEKMCYSALLMAMVFSTGEQIPLHHYEHLNAGFLQFLLDVIEDGLPT------------------DSTE--------QLPDLFINVLLAFNLHLSVPDSNIVMQTL-MKRDNAKILSEKLLLLLNRGEDPVCVFSHA---------PAAPHAVVKFLQDVFSSADSAQIFYRSDLMVLIDITVRQISDLEPGDRMRAQYLSLMLSVMRCSEYQEH-RHRLADLRAALQRILGEEESGAAERSIVLQIYEEFPDT 756
[Close]
BLAST of SH3 domain protein vs. Ensembl Xenopus
Match: arl1 (ADP ribosylation factor like GTPase 1 [Source:Xenbase;Acc:XB-GENE-961332])

HSP 1 Score: 124.79 bits (312), Expect = 2.960e-29
Identity = 117/430 (27.21%), Postives = 197/430 (45.81%), Query Frame = 2 
Query:  398 EKPTPPSL-IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSG----DWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALN 1672
            E PT  ++ +P  +   L +++R++T  S++ S   + +++  ++ SVP        I   L+ +       A   SG    D   L  +F    + K+D Q+RSW+L+ED N +      LL IL   +  +     +  +++  LSL+  YQME R+ LR LLL+ F   C ++   I   + S+LP+EL RD+       +   Y++L+L ++ +  + +     E LN +F   +L    E     L S ++ +                      + D+ +  LL+FN        N I+ +L  +P   ++F EKL+  FNR  DP     +         Q    +SV KIL D+ +SK  A L Y  D  V+IDII R++ +L        EYL L+  I+ ++DYL+   ++  DL   L 
Sbjct:  252 ESPTHDAVTVPKTIGAELIELVRKNTNLSYELSRVAIGVIVGHIQASVPSTASAMEQILVTLVESKD---SGAGLPSGQVCHDEQRLEVIFADLARHKDDAQQRSWALYEDENVILCYLEELLLILTDADPEVCKRMCKRNHFEAVLSLVAYYQMEHRVPLRLLLLKCFGAMCNLDASIISALVNSVLPMELARDMQTHTQEHQKMCYSALVLAMIFSMGEPLPYHHYEHLNSQFVQFLL----EVIEDGLPSDITEQ----------------------LPDLFINVLLAFNLHIPVPANNVIMKTLVKQPN-VKVFTEKLLLIFNRGDDPVAIFKH---------QPQPPHSVLKILQDVFASKDTAHLFYHTDMMVMIDIIVRQIADLSPGDKLRMEYLSLMHAIIRSTDYLQHA-HRQTDLHGILQ 641
[Close]
BLAST of SH3 domain protein vs. Ensembl Xenopus
Match: arl1 (ADP ribosylation factor like GTPase 1 [Source:Xenbase;Acc:XB-GENE-961332])

HSP 1 Score: 124.02 bits (310), Expect = 7.408e-29
Identity = 114/421 (27.08%), Postives = 192/421 (45.61%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSG----DWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALN 1672
            +P  +   L +++R++T  S++ S   + +++  ++ SVP        I   L+ +       A   SG    D   L  +F    + K+D Q+RSW+L+ED N +      LL IL   +  +     +  +++  LSL+  YQME R+ LR LLL+ F   C ++   I   + S+LP+EL RD+       +   Y++L+L ++ +  + +     E LN +F   +L    E     L S ++ +                      + D+ +  LL+FN        N I+ +L  +P   ++F EKL+  FNR  DP     +         Q    +SV KIL D+ +SK  A L Y  D  V+IDII R++ +L        EYL L+  I+ ++DYL+   ++  DL   L 
Sbjct:  329 VPKTIGAELIELVRKNTNLSYELSRVAIGVIVGHIQASVPSTASAMEQILVTLVESKD---SGAGLPSGQVCHDEQRLEVIFADLARHKDDAQQRSWALYEDENVILCYLEELLLILTDADPEVCKRMCKRNHFEAVLSLVAYYQMEHRVPLRLLLLKCFGAMCNLDASIISALVNSVLPMELARDMQTHTQEHQKMCYSALVLAMIFSMGEPLPYHHYEHLNSQFVQFLL----EVIEDGLPSDITEQ----------------------LPDLFINVLLAFNLHIPVPANNVIMKTLVKQPN-VKVFTEKLLLIFNRGDDPVAIFKH---------QPQPPHSVLKILQDVFASKDTAHLFYHTDMMVMIDIIVRQIADLSPGDKLRMEYLSLMHAIIRSTDYLQHA-HRQTDLHGILQ 709

HSP 2 Score: 56.225 bits (134), Expect = 1.298e-7
Identity = 26/72 (36.11%), Postives = 44/72 (61.11%), Query Frame = 2 
Query:   47 LWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSE-KEGTLGCVPINYMKMIDMPEK-KILKYIDKAI 256
            ++  LY++    P SL F A E FL+L + N++W+L S    G  G VP +Y++   + E+ ++L+ ID+AI
Sbjct:    1 MYRALYAFRSPEPNSLLFGAGESFLILERSNQHWWLASRCSSGETGYVPASYLERTQVQEQDQVLQSIDRAI 72
[Close]
BLAST of SH3 domain protein vs. Ensembl Xenopus
Match: arl1 (ADP ribosylation factor like GTPase 1 [Source:Xenbase;Acc:XB-GENE-961332])

HSP 1 Score: 123.635 bits (309), Expect = 8.433e-29
Identity = 114/421 (27.08%), Postives = 192/421 (45.61%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSG----DWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALN 1672
            +P  +   L +++R++T  S++ S   + +++  ++ SVP        I   L+ +       A   SG    D   L  +F    + K+D Q+RSW+L+ED N +      LL IL   +  +     +  +++  LSL+  YQME R+ LR LLL+ F   C ++   I   + S+LP+EL RD+       +   Y++L+L ++ +  + +     E LN +F   +L    E     L S ++ +                      + D+ +  LL+FN        N I+ +L  +P   ++F EKL+  FNR  DP     +         Q    +SV KIL D+ +SK  A L Y  D  V+IDII R++ +L        EYL L+  I+ ++DYL+   ++  DL   L 
Sbjct:  306 VPKTIGAELIELVRKNTNLSYELSRVAIGVIVGHIQASVPSTASAMEQILVTLVESKD---SGAGLPSGQVCHDEQRLEVIFADLARHKDDAQQRSWALYEDENVILCYLEELLLILTDADPEVCKRMCKRNHFEAVLSLVAYYQMEHRVPLRLLLLKCFGAMCNLDASIISALVNSVLPMELARDMQTHTQEHQKMCYSALVLAMIFSMGEPLPYHHYEHLNSQFVQFLL----EVIEDGLPSDITEQ----------------------LPDLFINVLLAFNLHIPVPANNVIMKTLVKQPN-VKVFTEKLLLIFNRGDDPVAIFKH---------QPQPPHSVLKILQDVFASKDTAHLFYHTDMMVMIDIIVRQIADLSPGDKLRMEYLSLMHAIIRSTDYLQHA-HRQTDLHGILQ 686
[Close]
BLAST of SH3 domain protein vs. Ensembl Xenopus
Match: arl1 (ADP ribosylation factor like GTPase 1 [Source:Xenbase;Acc:XB-GENE-961332])

HSP 1 Score: 123.635 bits (309), Expect = 8.865e-29
Identity = 114/421 (27.08%), Postives = 192/421 (45.61%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSG----DWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALN 1672
            +P  +   L +++R++T  S++ S   + +++  ++ SVP        I   L+ +       A   SG    D   L  +F    + K+D Q+RSW+L+ED N +      LL IL   +  +     +  +++  LSL+  YQME R+ LR LLL+ F   C ++   I   + S+LP+EL RD+       +   Y++L+L ++ +  + +     E LN +F   +L    E     L S ++ +                      + D+ +  LL+FN        N I+ +L  +P   ++F EKL+  FNR  DP     +         Q    +SV KIL D+ +SK  A L Y  D  V+IDII R++ +L        EYL L+  I+ ++DYL+   ++  DL   L 
Sbjct:  308 VPKTIGAELIELVRKNTNLSYELSRVAIGVIVGHIQASVPSTASAMEQILVTLVESKD---SGAGLPSGQVCHDEQRLEVIFADLARHKDDAQQRSWALYEDENVILCYLEELLLILTDADPEVCKRMCKRNHFEAVLSLVAYYQMEHRVPLRLLLLKCFGAMCNLDASIISALVNSVLPMELARDMQTHTQEHQKMCYSALVLAMIFSMGEPLPYHHYEHLNSQFVQFLL----EVIEDGLPSDITEQ----------------------LPDLFINVLLAFNLHIPVPANNVIMKTLVKQPN-VKVFTEKLLLIFNRGDDPVAIFKH---------QPQPPHSVLKILQDVFASKDTAHLFYHTDMMVMIDIIVRQIADLSPGDKLRMEYLSLMHAIIRSTDYLQHA-HRQTDLHGILQ 688
[Close]
BLAST of SH3 domain protein vs. Ensembl Mouse
Match: Nckipsd (NCK interacting protein with SH3 domain [Source:MGI Symbol;Acc:MGI:1931834])

HSP 1 Score: 96.2857 bits (238), Expect = 3.328e-20
Identity = 103/430 (23.95%), Postives = 195/430 (45.35%), Query Frame = 2 
Query:  398 EKPTPPSLIPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNT--SKFHLEKAFYNS---GDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALN 1672
            EK    +++P  +   L +++R++T  SH+     + +++  ++ +VP     ++ I  Q+L +      L  A  +     D   L  +F    +RK+D Q+RSW+L+ED + ++     LL IL   +  +     +  +++  L+L+  YQME R  LR LLL+ F   C ++   I   + S+LP+EL RD+     + +   Y++L+L ++ +  + +     E L   F   +L  + +     +D++                          + D+ +  LL+ N      ++N I+ +L  +    ++F EKL+   NR  DP           I   +    +SV K L D+ SS   A + Y  D   +IDI  R++ +L        EYL L+  +V ++ YL+  +++  DL++ L 
Sbjct:  292 EKAAAETVVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHIQATVP----ASSPIMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEDVIRCYLEELLHILTDADPEVCKKMCKRSDFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALVLAMVFSMGEAVPYAHYEHLGTPFAQFLLSIVED--GLPMDTTEQ------------------------LPDLCMNLLLALNLHLTAPEQNVIMAALS-RHTNVKIFSEKLLLLLNRGDDPV---------RIFRHEPQPPHSVLKFLQDVFSSSATAAIFYHTDMMALIDITVRQIADLSPGDKLRMEYLSLMHAVVRSTPYLQH-RHRLSDLQATLR 680

HSP 2 Score: 55.8398 bits (133), Expect = 1.499e-7
Identity = 23/71 (32.39%), Postives = 42/71 (59.15%), Query Frame = 2 
Query:   47 LWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSE-KEGTLGCVPINYMKMIDMPEKKILKYIDKAI 256
            ++  LY++    P +++F A E FLVL + + +W+L +  + G  G VP  Y+  +   E+ +L+ ID+AI
Sbjct:    1 MYRALYAFRSAEPNAMAFAAGETFLVLERSSTHWWLAARARSGETGYVPPAYLHRLQGMEQDVLQAIDRAI 71
[Close]
BLAST of SH3 domain protein vs. Ensembl Mouse
Match: Nckipsd (NCK interacting protein with SH3 domain [Source:MGI Symbol;Acc:MGI:1931834])

HSP 1 Score: 96.2857 bits (238), Expect = 3.328e-20
Identity = 103/430 (23.95%), Postives = 195/430 (45.35%), Query Frame = 2 
Query:  398 EKPTPPSLIPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNT--SKFHLEKAFYNS---GDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALN 1672
            EK    +++P  +   L +++R++T  SH+     + +++  ++ +VP     ++ I  Q+L +      L  A  +     D   L  +F    +RK+D Q+RSW+L+ED + ++     LL IL   +  +     +  +++  L+L+  YQME R  LR LLL+ F   C ++   I   + S+LP+EL RD+     + +   Y++L+L ++ +  + +     E L   F   +L  + +     +D++                          + D+ +  LL+ N      ++N I+ +L  +    ++F EKL+   NR  DP           I   +    +SV K L D+ SS   A + Y  D   +IDI  R++ +L        EYL L+  +V ++ YL+  +++  DL++ L 
Sbjct:  292 EKAAAETVVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHIQATVP----ASSPIMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEDVIRCYLEELLHILTDADPEVCKKMCKRSDFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALVLAMVFSMGEAVPYAHYEHLGTPFAQFLLSIVED--GLPMDTTEQ------------------------LPDLCMNLLLALNLHLTAPEQNVIMAALS-RHTNVKIFSEKLLLLLNRGDDPV---------RIFRHEPQPPHSVLKFLQDVFSSSATAAIFYHTDMMALIDITVRQIADLSPGDKLRMEYLSLMHAVVRSTPYLQH-RHRLSDLQATLR 680

HSP 2 Score: 55.8398 bits (133), Expect = 1.499e-7
Identity = 23/71 (32.39%), Postives = 42/71 (59.15%), Query Frame = 2 
Query:   47 LWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSE-KEGTLGCVPINYMKMIDMPEKKILKYIDKAI 256
            ++  LY++    P +++F A E FLVL + + +W+L +  + G  G VP  Y+  +   E+ +L+ ID+AI
Sbjct:    1 MYRALYAFRSAEPNAMAFAAGETFLVLERSSTHWWLAARARSGETGYVPPAYLHRLQGMEQDVLQAIDRAI 71
[Close]
BLAST of SH3 domain protein vs. UniProt/SwissProt
Match: sp|Q9NZQ3|SPN90_HUMAN (NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 3.438e-20
Identity = 105/427 (24.59%), Postives = 185/427 (43.33%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSG----DWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKNDD 1690
            +P  +   L +++R++T  SH+     + I++  ++ SVP        +   L+      +      SG    D   L  +F    +RK+D Q+RSW+L+ED   ++     LL IL   +  +     +   ++  L+L+  YQME R  LR LLL+ F   C ++   I   + S+LP+EL RD+     + +   Y++L+L ++ +  + +     E L   F   +L  + +     LD++                          + D+ V  LL+ N       +N I+ +L  K    ++F EKL+   NR  DP           I   +    +SV K L D+  S   A + Y  D   +IDI  R + +L        EYL L+  IV  + YL+  +++  DL++ L  + N++
Sbjct:  308 VPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMA---LPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVED--GLPLDTTEQ------------------------LPDLCVNLLLALNLHLPAADQNVIMAALS-KHANVKIFSEKLLLLLNRGDDPV---------RIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAIVRTTPYLQH-RHRLPDLQAILRRILNEE 694
[Close]
BLAST of SH3 domain protein vs. UniProt/SwissProt
Match: sp|Q9ESJ4|SPN90_MOUSE (NCK-interacting protein with SH3 domain OS=Mus musculus OX=10090 GN=Nckipsd PE=1 SV=2)

HSP 1 Score: 96.2857 bits (238), Expect = 2.328e-19
Identity = 103/430 (23.95%), Postives = 195/430 (45.35%), Query Frame = 2 
Query:  398 EKPTPPSLIPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNT--SKFHLEKAFYNS---GDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALN 1672
            EK    +++P  +   L +++R++T  SH+     + +++  ++ +VP     ++ I  Q+L +      L  A  +     D   L  +F    +RK+D Q+RSW+L+ED + ++     LL IL   +  +     +  +++  L+L+  YQME R  LR LLL+ F   C ++   I   + S+LP+EL RD+     + +   Y++L+L ++ +  + +     E L   F   +L  + +     +D++                          + D+ +  LL+ N      ++N I+ +L  +    ++F EKL+   NR  DP           I   +    +SV K L D+ SS   A + Y  D   +IDI  R++ +L        EYL L+  +V ++ YL+  +++  DL++ L 
Sbjct:  292 EKAAAETVVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHIQATVP----ASSPIMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEDVIRCYLEELLHILTDADPEVCKKMCKRSDFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALVLAMVFSMGEAVPYAHYEHLGTPFAQFLLSIVED--GLPMDTTEQ------------------------LPDLCMNLLLALNLHLTAPEQNVIMAALS-RHTNVKIFSEKLLLLLNRGDDPV---------RIFRHEPQPPHSVLKFLQDVFSSSATAAIFYHTDMMALIDITVRQIADLSPGDKLRMEYLSLMHAVVRSTPYLQH-RHRLSDLQATLR 680
[Close]
BLAST of SH3 domain protein vs. TrEMBL
Match: A0A4Z2DN27 (NCK-interacting protein with SH3 domain isoform 2 OS=Schistosoma japonicum OX=6182 GN=EWB00_010802 PE=4 SV=1)

HSP 1 Score: 184.882 bits (468), Expect = 2.410e-46
Identity = 179/644 (27.80%), Postives = 302/644 (46.89%), Query Frame = 2 
Query:   56 TLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSEKEGTLGCVPINYMKMIDMPEKKILK-YIDKAIISLSQKSAXXXXXXXXXXXXLLEFKDQTIXXXXXXXXXXXXXXXXSCEKPTP--------------PSL----IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASL---LLTILINGCDMMNIDLQERLNVEFCVAM--LYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVG-FLLSFNKRFKNV------------KKNPIITSLQLKPECTRLFIEKLIRAF---------------NRDYDPA-----------LTTSYIDDSE-------------------------------IENVQKS-----------------SSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYD 1654
             +Y Y G FPG+L F  +E+FL +R+ENEYW LVS+ +GTLGCVP N++K  +  +  +++ Y  KA+ISL+  S   I  +D++++ LLE   +  +           ++ +  EK  P              P+L    +P      L D IR  T  S+         +++ L T +P++K  +  + N   +T++   EK +  S DW  L     +F+ R+N++QE +WSLH++ +D+  + + L+ +L+  +  LV  +L    + P LSLI LYQ E    +R  LL+   +CC ++   I ICL SILP+E+VR+L  ++  D  F++ +L    L+IL+   + + +DL    + +    +  L   ++   + +D  +  +   +     D  + +      YM    V  FLL+ N  F +V             K+P++ +L  KP  +RLF+E +I+ F               N+ YDP              +++ D S+                               I N+ +S                   +SV K LCD+ S    A LIY ND DVII++I+R++ +  +NS  L   L+LLDLI +NS+ +++G  K +D
Sbjct:    4 AVYPYEGPFPGTLKFSRDEIFLDIREENEYWRLVSKIDGTLGCVPTNFVKRCETKDDGLIQQYARKALISLTASSEKEIQGKDDLVKLLLEIARKKPDENKILCEEFSNLKMSVREKSEPTRDTALTLKAENTTPTLKAIDLPKNFESRLVDTIRLGTNCSYSNCRAVFFAVIDLLST-IPEMKQ-SFQVYNMSSDTAR--TEKDYSQSPDWYLLKIKLGYFESRQNNDQECNWSLHDNKHDILERLNELITLLERADPKLVTCYLHFAKFQPVLSLIGLYQRETINQIRSRLLRSIGICCSLDSDCIRICLGSILPIEIVRELRFSSRRD--FSHLALRLRFLSILVAQSESLPVDLYASFDQDLFTHLIDLCDTTKEEQSLID--VENQTPDNQILVADEFDQYEQNSQYYMLSYSVAVFLLACNWHFTSVYRLSTPESNLVDSKSPLLKALLAKPIASRLFLETIIQTFNRHLDPTFMITFLPDNKHYDPVNDLTQWASFARFDSNWTDSSKKNLEDFLKNFEANSHSHRNIHNDLEYIQSLWIRNINQSVGSSSKPTLPVHANIITPPDSVVKFLCDLFSFSDTAALIYHNDLDVIIEVINRKMRDEGSNSELLPHLLLLLDLICINSNIVDKGSSKIHD 639
[Close]
BLAST of SH3 domain protein vs. TrEMBL
Match: A0A4Z2DMY5 (NCK-interacting protein with SH3 domain isoform 1 OS=Schistosoma japonicum OX=6182 GN=EWB00_010802 PE=4 SV=1)

HSP 1 Score: 179.489 bits (454), Expect = 2.203e-44
Identity = 180/656 (27.44%), Postives = 302/656 (46.04%), Query Frame = 2 
Query:   56 TLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSEKEGTLGCVPINYMKMIDM-------------PEKKILKYIDKAIISLSQKSAXXXXXXXXXXXXLLEFKDQTIXXXXXXXXXXXXXXXXSCEKPTP--------------PSL----IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASL---LLTILINGCDMMNIDLQERLNVEFCVAM--LYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVG-FLLSFNKRFKNV------------KKNPIITSLQLKPECTRLFIEKLIRAF---------------NRDYDPA-----------LTTSYIDDSE-------------------------------IENVQKS-----------------SSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYD 1654
             +Y Y G FPG+L F  +E+FL +R+ENEYW LVS+ +GTLGCVP N++K  ++              +  I +Y  KA+ISL+  S   I  +D++++ LLE   +  +           ++ +  EK  P              P+L    +P      L D IR  T  S+         +++ L T +P++K  +  + N   +T++   EK +  S DW  L     +F+ R+N++QE +WSLH++ +D+  + + L+ +L+  +  LV  +L    + P LSLI LYQ E    +R  LL+   +CC ++   I ICL SILP+E+VR+L  ++  D  F++ +L    L+IL+   + + +DL    + +    +  L   ++   + +D  +  +   +     D  + +      YM    V  FLL+ N  F +V             K+P++ +L  KP  +RLF+E +I+ F               N+ YDP              +++ D S+                               I N+ +S                   +SV K LCD+ S    A LIY ND DVII++I+R++ +  +NS  L   L+LLDLI +NS+ +++G  K +D
Sbjct:    4 AVYPYEGPFPGTLKFSRDEIFLDIREENEYWRLVSKIDGTLGCVPTNFVKRCEVICGVFLKVNCKTKDDGLIQQYARKALISLTASSEKEIQGKDDLVKLLLEIARKKPDENKILCEEFSNLKMSVREKSEPTRDTALTLKAENTTPTLKAIDLPKNFESRLVDTIRLGTNCSYSNCRAVFFAVIDLLST-IPEMKQ-SFQVYNMSSDTAR--TEKDYSQSPDWYLLKIKLGYFESRQNNDQECNWSLHDNKHDILERLNELITLLERADPKLVTCYLHFAKFQPVLSLIGLYQRETINQIRSRLLRSIGICCSLDSDCIRICLGSILPIEIVRELRFSSRRD--FSHLALRLRFLSILVAQSESLPVDLYASFDQDLFTHLIDLCDTTKEEQSLID--VENQTPDNQILVADEFDQYEQNSQYYMLSYSVAVFLLACNWHFTSVYRLSTPESNLVDSKSPLLKALLAKPIASRLFLETIIQTFNRHLDPTFMITFLPDNKHYDPVNDLTQWASFARFDSNWTDSSKKNLEDFLKNFEANSHSHRNIHNDLEYIQSLWIRNINQSVGSSSKPTLPVHANIITPPDSVVKFLCDLFSFSDTAALIYHNDLDVIIEVINRKMRDEGSNSELLPHLLLLLDLICINSNIVDKGSSKIHD 651
[Close]
BLAST of SH3 domain protein vs. TrEMBL
Match: C1LF53 (SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 177.178 bits (448), Expect = 2.250e-44
Identity = 142/487 (29.16%), Postives = 245/487 (50.31%), Query Frame = 2 
Query:   56 TLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSEKEGTLGCVPINYMKMIDMPEKKILK-YIDKAIISLSQKSAXXXXXXXXXXXXLLEFKDQTIXXXXXXXXXXXXXXXXSCEKPTP--------------PSL----IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASL---LLTILINGCDMMNIDLQERLNVEFCVAM--LYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVG-FLLSFNKRFKNV------------KKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDD 1405
             +Y Y G FPG+L F  +E+FL +R+ENEYW LVS+ +GTLGCVP N++K  +  +  +++ Y  KA+ISL+  S   I  +D++++ LLE   +  +           ++ +  EK  P              P+L    +P      L D IR  T  S+         +++ L T +P++K  +  + N   +T++   EK +  S DW  L     +F+ R+N++QE +WSLH++ +D+  + + L+ +L+  +  LV  +L    + P LSLI LYQ E    +R  LL+   +CC ++   I ICL SILP+E+VR+L  ++  D  F++ +L    L+IL+   + + +DL    + +    +  L   ++   + +D  +  +   +     D  + +      YM    V  FLL+ N  F +V             K+P++ +L  KP  +RLF+E +I+ FNR  DP    +++ D
Sbjct:    4 AVYPYEGPFPGTLKFSRDEIFLDIREENEYWRLVSKIDGTLGCVPTNFVKRCETKDDGLIQQYARKALISLTASSEKEIQGKDDLVKLLLEIARKKPDENKILCEEFSNLKMSVREKSEPTRDTALTLKAENTTPTLKAIDLPKNFESRLVDTIRLGTNCSYSNCRAVFFAVIDLLST-IPEMKQ-SFQVYNMSSHTAR--TEKDYSQSPDWYLLKIKLGYFESRQNNDQECNWSLHDNKHDILERLNELITLLERADPKLVTCYLHFAKFQPVLSLIGLYQRETINQIRSRLLRSIGICCSLDSDCIRICLGSILPIEIVRELRFSSRRD--FSHLALRLRFLSILVAQSESLPVDLYASFDQDLFTHLIDLCDTTKEEQSLID--VENQTPDNQILVADEFDQYEQNSQYYMLSYSVAVFLLACNWHFTSVYRLSTPESNLVDSKSPLLKALLAKPIASRLFLETIIQTFNRHLDPTFMITFLPD 482
[Close]
BLAST of SH3 domain protein vs. TrEMBL
Match: A0A5J4P296 (SH3 domain-containing protein OS=Paragonimus westermani OX=34504 GN=DEA37_0000664 PE=4 SV=1)

HSP 1 Score: 174.096 bits (440), Expect = 1.732e-42
Identity = 141/538 (26.21%), Postives = 252/538 (46.84%), Query Frame = 2 
Query:   56 TLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSEKEGTLGCVPINYMK--------MIDMPEKKILKYIDKAIISLSQKSAXXXXXXXXXX------XXLLEFKDQTIXXXXXXXXXXXXXXXXSCEKP-----TPPS--LIPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDL--MDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDS--SLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRF---------KNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSY---IDDSEI-------ENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIIS 1537
             +Y Y   F G L F  NE FL +R+EN++WFLVS  +GTLGCVP NY++           +  K+ L  ID+  + ++ K       R            +L      +      +    + +  +  +P     TP +  +IP GL+  L + +R  T +S+     T +ILL+ L++ +PDL+ +T+ +   L N++       +  S DW+ L        + + D+QER+WSLH++  +L+     L  +L   +  L+  + +  NY P  S+++LYQ E R  +R+ LL    + C ++     + L S+LP EL+R+L  +D + + ++      LLT+L      + +D++++LNV+F   +L  +       + S   L   + S  T      ++FN +    +       LL+ N  F         ++  K P++ +L  +P  ++ F+E +I+AFNRD DP +   +   +++S I       E V   SS    +   DI  +  +A +    DE+  + +IS
Sbjct:    5 AIYPYEPPFKGCLKFFPNEQFLKIREENQFWFLVSTSDGTLGCVPYNYVQEDEDQNEQTTAILAKRALTSIDRCGVQVANKDEISKVLRRLAKEPDENNHTVLSQPVSPVPHPKTLIGRNPIPKTEASNQPSKNNVTPSAGKIIPGGLSLRLVNALRLGTNSSYSECHSTFRILLDILESEIPDLRPYTSVLQTLLTNSTTEECHLGYNLSPDWHTLNFCLGKLLKFQQDDQERNWSLHDEQTELEQVLVALTDVLMKADRELLRYYFKFSNYRPLQSMLQLYQSESRASIRRKLLLCVGMVCSLDDACSRVVLASVLPHELIRELTTVDNDADVRHTATGMRLLTLLFAQAKELPVDVKDKLNVDFLAKILRFVGSIEKPQVTSLIDLDPFDASVSTEAVAQEKLFNGR----LAHAATVLLLACNWHFCSAAAARMNQSTTKLPLLAALMAQPSASKCFLELVIQAFNRDLDPIVYVDFKCPVNESRINRLICWVEAVSGMSSTHTSQDESDIRDNSSIAKVFEGIDEESDMFLIS 538

HSP 2 Score: 72.4034 bits (176), Expect = 2.161e-9
Identity = 37/88 (42.05%), Postives = 59/88 (67.05%), Query Frame = 2 
Query: 1439 NSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLP-ANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKNDDIND 1699
            +SV K+L D+  S + A L+Y +D+DV++D+I+R+LCNL   +S  +  Y +LL LI+ NSDY+ RG ++S +L   L+ L   D+ D
Sbjct:  576 HSVVKLLLDLFGSVETAGLVYGSDQDVVVDVITRQLCNLSLKDSQGILNYPVLLSLIIANSDYVARGAHRSRELIDGLSALLATDLPD 663
[Close]
BLAST of SH3 domain protein vs. TrEMBL
Match: G4VD73 (SH3 domain-containing protein OS=Schistosoma mansoni OX=6183 GN=Smp_128280.1 PE=4 SV=1)

HSP 1 Score: 170.244 bits (430), Expect = 8.174e-42
Identity = 161/598 (26.92%), Postives = 280/598 (46.82%), Query Frame = 2 
Query:   56 TLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSEKEGTLGCVPINYMKMIDMPEKKILKY-IDKAIISLSQKSAXXXXXXXXXXXXLLEFKDQTIXXXXXXXXXXXXXXXXSCEKPTP------------PSLIPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASL-LLTILINGCDMMNIDLQERLNVEFCVAM--LYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIY--MDDVIVGFLLSFNKRFKNV---------------KKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKNDDINDFDKTLIDSILEKLDHTV 1750
             +Y Y G FPG+L F  +E+FL +R+ENEYW LVS+ +GTLGCVP N++K  +  ++  ++    KA+ +L+  S+  +  +D++++ LL+   +  N           ++ +  EKP               S +P      L D IR  T  S+    +++   +  L +++P+LK       N   +T +  L+  +  S DW  L     +F+ R++++QE +W LHED +D+  + + L  +L+  +  LV+ +L +  + P LSL+ LYQ E    +R  LL+   + C ++   I +CL S+LP EL+R+L  ++  +  +    L  L++LI+    + +DL + L+ E    +  L   S+  ++ +D  L      +     D  + F   D  Y      +  FLL+ N  F +V                K P++ +L  KP  +RLF+E +I+ FNR Y  A                                     LIY+ND DVII++I+R + +   NS  L   L+LL+LI +N++   +   K  D    L+ L    ++   KTL  +  +++   V
Sbjct:    4 AIYPYEGPFPGTLKFSRDEIFLDIREENEYWRLVSKTDGTLGCVPTNFVKRCEAKDESFVQQCAKKALANLTASSSDELRGKDDLMKRLLQICREKPNENTTPCEEFSELKISVIEKPVSMTGTVGLIPAKQSSSLPKNFESCLVDTIRLGTNCSYA-DCRSVYYAIVDLLSTIPELKQNFQGY-NSTSDTVETELD--YSRSPDWYLLKIKLGYFESRQSNDQECNWGLHEDRHDIIERLNELNTLLEKADPKLVVCYLHSVKFLPLLSLVGLYQRETMNKIRSKLLRSVGILCSLDSACIRVCLGSVLPTELIRELRGSSHCEIPYLALRLRFLSLLISQSQTLPVDLHKSLDQELFTHLINLCDTSKQKSSLID--LENHSPGNQILVTDGLDPFEQNDGQYYMFSYAVALFLLACNWHFCSVYMLNSSETSSPNTTDNKTPLLKALLAKPVSSRLFLEIIIQTFNRHYTGA-------------------------------------LIYQNDLDVIIEVINRRMRDEEPNSEHLPHLLLLLNLICINTNIANKSSLKINDTMEILSPLSQASLSPRSKTLAMAAHQQIKSVV 558
[Close]
BLAST of SH3 domain protein vs. Ensembl Cavefish
Match: nckipsd (NCK interacting protein with SH3 domain [Source:ZFIN;Acc:ZDB-GENE-130326-2])

HSP 1 Score: 109.383 bits (272), Expect = 1.599e-24
Identity = 108/424 (25.47%), Postives = 193/424 (45.52%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNS---GDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPI-YMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILK 1681
            +P      L +++R++T  S++ S   + +++  L+T++P        +   L+ +    L  A        D   L  +F    + ++D+Q+RSW+L+ED   +      LL+IL   +  +      A + +P LSL+  YQME R+ LR LLL++F   C ++   I   + SILP+EL RDL       +   Y +L+L ++                  FC  M  ++   H   L+SS          F  D  E     DP   + D+ +  LL+FN      + N ++ +L +K    +   EK++   NR  DP     +         +  + +SV K L D+ +S+   D+ Y  D  V+IDI  R++ +L        EYL L+  I+ ++DY++  +++  DL++ L  ++
Sbjct:  236 VPMTTGAELIELVRKNTGLSYEMSRVAVGVVVGHLQTTIPSASADLEQVLLSLVESKD--LSTALPQGQVCHDEQRLEVIFGDLARHRDDSQQRSWALYEDHELIACYLEELLQILTDADPEVCKKMCRANHSEPVLSLVSYYQMEHRVSLRLLLLKVFGAMCGLDGSLISTLINSILPMELARDLQTNTQEHQKMCYTALVLAMI------------------FC--MGEQVPYRHYDHLNSSF-------IQFLLDVIEDGISSDPTEQLPDLFINVLLAFNLHLTVPEDNMVMQTL-IKRHNVKTLSEKILLLLNRGEDPVCVFKH---------EPPAPHSVLKFLQDVFASRDTGDIFYHTDMMVMIDIAVRQISDLSPGDKLRMEYLSLMHAIMRSTDYMQH-QHRLPDLQATLQRIQ 619

HSP 2 Score: 55.8398 bits (133), Expect = 1.047e-7
Identity = 25/72 (34.72%), Postives = 44/72 (61.11%), Query Frame = 2 
Query:   47 LWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSE-KEGTLGCVPINYMKMIDMPEK-KILKYIDKAI 256
            ++ +L+++    P SL F   E FL+L + N++W+L S    G  G +P +Y++ I  PE+  +L+ ID+AI
Sbjct:    1 MYRSLFAFRSGEPNSLRFSPGETFLILERSNQHWWLGSRCSSGETGYIPASYIEKIQAPEQDDVLQSIDRAI 72
[Close]
BLAST of SH3 domain protein vs. Ensembl Sea Lamprey
Match: nckipsd (NCK interacting protein with SH3 domain [Source:ZFIN;Acc:ZDB-GENE-130326-2])

HSP 1 Score: 70.0922 bits (170), Expect = 5.508e-13
Identity = 56/192 (29.17%), Postives = 93/192 (48.44%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPD---------LKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDL 970
            +P  +   LT+++R++T  S++ S   +  ++  ++ ++PD         L + T  +  Q L               D   L  +F    + K+D Q+RSW+LHED   +      LL IL   N  +     +  + +P LSL+  YQME R+ LR LLL++F   C ++   I   L S+LP+EL RD+
Sbjct:  292 VPRTMGVELTELVRRNTGLSYELSRVAIGTVVGHIRDTLPDTADIMEDILLSLLTQQVGGQELPEG--------LECQDVTRLNVIFTDLARHKDDAQQRSWALHEDEAVISSYLQELLSILTDANPDVSRRMCKRDDCEPVLSLVSYYQMEHRVSLRLLLLKVFGAMCSLDANIISALLNSVLPMELARDM 475
[Close]
BLAST of SH3 domain protein vs. Ensembl Nematostella
Match: EDO30013 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T203])

HSP 1 Score: 102.449 bits (254), Expect = 7.823e-23
Identity = 115/446 (25.78%), Postives = 205/446 (45.96%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDL-----KMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKNDDINDF--DKTLIDSILEKL 1738
            +P   A  L + +R +T  S+  S    + ++  ++  VP       +M       Q+L++S +H  +    + D   +  +     + K+D Q+RSW+L  D   +  + + LL +L     S+  + +    Y    SL+  +QME R  LR LLL++F   C +++  I   L S+LP EL    M T  +D         L + ++ C ++ +       V + +      S+F N  +       E      GED  +I          +  V  LL+FN+ F + K N I+ ++  +    +   E+L+   NR+ DP +   Y          KS +NSV KI  D+ SS   + L +  D  V+I+I+ R+L +L       +EYL LL+L++ NSDY    ++   DL++ L  +++++  +   DKT++ +IL+K 
Sbjct:  209 LPARFAADLLEQLRINTGISYDTSFAAAETVISHIREKVPSTAGLMGRMLQELWAEQVLSSS-YH--QHLLITHDGQGIDNILRALTEHKDDAQQRSWALDMDEPIITKQLNDLLTLLSDARRSVSSAVIRQEEYGHLESLVVYFQMEHRRSLRLLLLKVFGSLCRVDQGVIPELLCSVLPGELASS-MQTYPDD---------LELQLSCCLILTMIFSTAEPVPYWLYADQLDSDFVNYVVQCVEEAPE------GEDGDKII---------ESFVHLLLAFNQHFTDPKTN-IVMNVLSELYSAKTVSEQLMLLVNREEDPVVMFDY---------PKSCANSVFKIFTDLFSSPSTSGLFFTADMKVLIEIVLRQLTDLSPGEKVRTEYLALLELMLTNSDYGSH-QHMCSDLRACLQRIRDEEAPESQQDKTIVKNILDKF 615
[Close]
BLAST of SH3 domain protein vs. Ensembl Nematostella
Match: EDO27985 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T7R3])

HSP 1 Score: 47.7506 bits (112), Expect = 4.333e-6
Identity = 48/198 (24.24%), Postives = 91/198 (45.96%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLL--NTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYA 1009
            +P   A  L + +R +T  S+  S    + ++  ++  VP        +  +L     +  H +++   + D   +  +     + K+D Q+RSW+L  D   +  + + LL +L     S+  + +   + +   SL+  +QME R  LR LLL++F   C +++  I   L S+LP EL    M T  +D ++  A
Sbjct:    7 LPARFAADLLEQLRINTGISYDTSFAAAETVISHIREKVPSTAGLMGRMLQELWAEQGTSDHSDESLLITHDGQGIENILRALTEHKDDAQQRSWALDMDEPIITKQLNDLLTLLSDARRSVSRAVIRQRSMEHMESLVVYFQMEHRRSLRLLLLKVFGSLCRVDQGVIPELLCSVLPGELASS-MQTYPDDTSYDNA 203
[Close]
BLAST of SH3 domain protein vs. Ensembl Medaka
Match: nckipsd (NCK interacting protein with SH3 domain [Source:NCBI gene;Acc:101161222])

HSP 1 Score: 111.694 bits (278), Expect = 3.799e-25
Identity = 108/420 (25.71%), Postives = 192/420 (45.71%), Query Frame = 2 
Query:  422 IPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNS---GDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALN 1672
            +P  +   L +++R++T  S++ S   + +++  L+ ++P        +   L+ +    L  A        D   L  +FD   +R++D+Q+RSW+LHED   +      LLKIL   +  +     +A + +  LSL+  YQME R+ LR LLL++F   C ++   I   L SILP+EL RDL       +   Y++L+LT++++  + +     E LN EF   +L  + +   +     L     +        H + +    + M +V            KNV                R+  EK++   NR  DP     +            + ++V K L D+ +S + A++ YR D  V+IDI  R++ +L        EYL L+  I+ ++DYLE  +++  DL+++L 
Sbjct:  312 VPATMGAELIELVRKNTGLSYELSRVAVGVVVGHLQAALPQAASSLEQVLVSLVESKD--LGGALPRGQVCHDEQRLEVIFDDLARRRDDSQQRSWALHEDHALIACYLEELLKILTDADPEVCKRMCKANHCENVLSLVSYYQMEHRVSLRLLLLKVFGAMCSLDAALISTLLNSILPMELARDLQTDTQEHQKMCYSALVLTMVLSMGEQVPYRHYEHLNAEFIRFVLGVVEDGLPSDPTEQLPDIFLNLLLAFNLHHTVPSSN--VLMQEVYQ----------KNV----------------RVLTEKVLLLLNRGDDPVCMFKHT---------PPAPHAVLKFLQDVFASPETANIFYRTDMMVMIDIAVRQISDLSPGDKLRMEYLSLMHAIIRSTDYLEH-QHRLRDLQASLQ 691

HSP 2 Score: 54.6842 bits (130), Expect = 2.269e-7
Identity = 27/72 (37.50%), Postives = 44/72 (61.11%), Query Frame = 2 
Query:   47 LWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSE-KEGTLGCVPINYMKMIDMPEK-KILKYIDKAI 256
            ++ +LY +    P SL F A E FL+L + N++W+L S    G  G +P +Y++ I  PE+ ++L  ID+AI
Sbjct:    1 MYRSLYPFRSTEPNSLYFAAGESFLILERSNKHWWLGSRCSSGETGYIPSSYIEKIQAPEQDEVLLSIDRAI 72
[Close]
BLAST of SH3 domain protein vs. Planmine SMEST
Match: SMESG000080362.1 (SMESG000080362.1)

HSP 1 Score: 1055.43 bits (2728), Expect = 0.000e+0
Identity = 573/573 (100.00%), Postives = 573/573 (100.00%), Query Frame = 2 
Query:   35 MNLKLWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSEKEGTLGCVPINYMKMIDMPEKKILKYIDKAIISLSQKSAXXXXXXXXXXXXLLEFKDQTIXXXXXXXXXXXXXXXXSCEKPTPPSLIPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEXXXXXXXXXXXXXXXCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKNDDINDFDKTLIDSILEKLDHTVI 1753
            MNLKLWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSEKEGTLGCVPINYMKMIDMPEKKILKYIDKAIISLSQKSASIISRRDEIIRDLLEFKDQTINRENNEVNVEKVIENNSCEKPTPPSLIPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEQRIVLRQLLLQIFIVCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKNDDINDFDKTLIDSILEKLDHTVI
Sbjct:    1 MNLKLWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSEKEGTLGCVPINYMKMIDMPEKKILKYIDKAIISLSQKSASIISRRDEIIRDLLEFKDQTINRENNEVNVEKVIENNSCEKPTPPSLIPDGLAFMLTDIIRQSTKASHKCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDWNDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLVISFLEAYNYDPFLSLIELYQMEQRIVLRQLLLQIFIVCCEINKKSIVICLQSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVEFCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDVIVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPALTTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDIISRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKNDDINDFDKTLIDSILEKLDHTVI 573
The following BLAST results are available for this feature:
BLAST of SH3 domain protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
NCKIPSD7.159e-2124.59NCK interacting protein with SH3 domain [Source:HG... [more]
NCKIPSD7.201e-2124.59NCK interacting protein with SH3 domain [Source:HG... [more]
NCKIPSD5.841e-1426.75NCK interacting protein with SH3 domain [Source:HG... [more]
NCKIPSD1.750e-733.80NCK interacting protein with SH3 domain [Source:HG... [more]
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BLAST of SH3 domain protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SH3 domain protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
CG22587.114e-2926.88gene:FBgn0029997 transcript:FBtr0340140[more]
CG22587.114e-2926.88gene:FBgn0029997 transcript:FBtr0071110[more]
CG22587.114e-2926.88gene:FBgn0029997 transcript:FBtr0071111[more]
CG22587.114e-2926.88gene:FBgn0029997 transcript:FBtr0071109[more]
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BLAST of SH3 domain protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
nckipsd5.767e-2624.83NCK interacting protein with SH3 domain [Source:ZF... [more]
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BLAST of SH3 domain protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
arl12.960e-2927.21ADP ribosylation factor like GTPase 1 [Source:Xenb... [more]
arl17.408e-2927.08ADP ribosylation factor like GTPase 1 [Source:Xenb... [more]
arl18.433e-2927.08ADP ribosylation factor like GTPase 1 [Source:Xenb... [more]
arl18.865e-2927.08ADP ribosylation factor like GTPase 1 [Source:Xenb... [more]
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BLAST of SH3 domain protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Nckipsd3.328e-2023.95NCK interacting protein with SH3 domain [Source:MG... [more]
Nckipsd3.328e-2023.95NCK interacting protein with SH3 domain [Source:MG... [more]
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BLAST of SH3 domain protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2
Match NameE-valueIdentityDescription
sp|Q9NZQ3|SPN90_HUMAN3.438e-2024.59NCK-interacting protein with SH3 domain OS=Homo sa... [more]
sp|Q9ESJ4|SPN90_MOUSE2.328e-1923.95NCK-interacting protein with SH3 domain OS=Mus mus... [more]
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BLAST of SH3 domain protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4Z2DN272.410e-4627.80NCK-interacting protein with SH3 domain isoform 2 ... [more]
A0A4Z2DMY52.203e-4427.44NCK-interacting protein with SH3 domain isoform 1 ... [more]
C1LF532.250e-4429.16SH3 adapter protein SPIN90 (NCK-interacting protei... [more]
A0A5J4P2961.732e-4226.21SH3 domain-containing protein OS=Paragonimus weste... [more]
G4VD738.174e-4226.92SH3 domain-containing protein OS=Schistosoma manso... [more]
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BLAST of SH3 domain protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
nckipsd1.599e-2425.47NCK interacting protein with SH3 domain [Source:ZF... [more]
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BLAST of SH3 domain protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
nckipsd5.508e-1329.17NCK interacting protein with SH3 domain [Source:ZF... [more]
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BLAST of SH3 domain protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SH3 domain protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO300137.823e-2325.78Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO279854.333e-624.24Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of SH3 domain protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
nckipsd3.799e-2525.71NCK interacting protein with SH3 domain [Source:NC... [more]
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BLAST of SH3 domain protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000080362.10.000e+0100.00SMESG000080362.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30016436 ID=SMED30016436|Name=SH3 domain protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1905bp
CATTCAATGCTGAATTATTCATATTAGTTCATATATGAATTTAAAATTGT
GGATAACTCTATATTCATATAATGGGGATTTTCCAGGCAGTCTTTCTTTC
AAAGCAAACGAATTATTTCTAGTTTTACGTAAAGAAAATGAATATTGGTT
TTTGGTCTCAGAAAAAGAAGGCACGCTTGGGTGTGTTCCGATTAATTACA
TGAAAATGATTGATATGCCTGAAAAGAAAATTCTCAAGTACATAGATAAA
GCCATTATTTCATTGAGTCAAAAGTCTGCATCTATTATCAGCCGAAGAGA
TGAAATTATAAGGGATCTACTGGAATTTAAAGATCAAACTATAAATCGAG
AAAATAATGAAGTTAACGTTGAAAAAGTAATTGAAAATAATTCTTGTGAA
AAACCGACTCCCCCATCATTGATACCTGATGGACTTGCCTTTATGTTAAC
CGATATCATTCGGCAGTCCACCAAAGCTAGTCATAAATGTTCTGTGAAGA
CTCTGCAGATTCTATTGGAAGCCCTAAAAACTAGTGTCCCGGATTTGAAA
ATGTGGACCAATTCAATAACAAATCAATTACTGAATACGTCAAAATTCCA
TTTGGAAAAGGCATTTTACAATAGTGGTGATTGGAATGACTTGACTGAAT
TATTTGATTTCTTTCAACAACGCAAAAATGACAATCAAGAACGTAGTTGG
TCTCTCCATGAGGATGTTAATGATTTGAAAATCAAATTCTCCACTCTCTT
AAAAATCCTTAAAACGTGCAATCACAGTTTGGTTATCAGTTTCCTAGAAG
CATACAATTATGATCCGTTTCTCTCATTAATAGAGCTATATCAAATGGAA
CAACGTATAGTGCTGCGGCAGTTGTTGTTACAAATCTTTATAGTTTGCTG
TGAAATTAATAAGAAATCTATTGTCATCTGTTTGCAGTCGATATTACCAT
TGGAACTAGTGCGGGATTTGATGGATACTAACATCAACGACAAAAATTTT
ACGTACGCTAGTTTATTGTTAACCATACTCATCAACGGTTGTGACATGAT
GAATATTGACCTCCAAGAGCGGTTAAATGTGGAATTTTGCGTTGCAATGT
TGTACAAGTTGAGTGAATTTCACAACACTGCGCTGGATTCGTCTCTATCT
GGTAAAGAAGAATCGTCTTGCACCTTTGGGGAAGACAGCCATGAAATCTT
TAATTTCAAGGATCCCATTTATATGGATGATGTTATAGTCGGATTTCTTC
TCTCTTTCAATAAAAGATTCAAAAACGTGAAAAAGAATCCAATAATAACT
AGTTTACAGCTAAAACCGGAATGCACAAGATTGTTTATTGAAAAATTGAT
TCGAGCTTTTAATAGGGACTATGATCCAGCCTTGACCACCTCGTATATTG
ATGATTCTGAAATTGAAAATGTGCAAAAATCCTCCTCAAATTCCGTTAGA
AAGATCTTATGTGATATTCACTCTAGTAAGAAATTGGCAGACCTCATATA
TCGGAATGATGAGGATGTAATCATTGACATTATCTCTAGGGAGTTGTGCA
ACTTGCCTGCAAATTCTACAGAATTGTCAGAATACTTGATGTTGCTCGAT
TTAATTGTATTAAATTCTGATTATTTGGAGCGAGGCAAATACAAATCGTA
TGATCTGAAAAGTGCATTAAACATTCTAAAAAATGACGATATAAATGATT
TTGACAAAACACTTATCGACTCAATTCTGGAAAAGTTGGACCATACTGTA
ATATAATTTGTTTTATTTTCTATTGGTGTCTTCGTTTATTTATCGACCTA
GTGCTGCTCGTCTTGGAATATTGAGCTGTGTATTCCTAATGATAACTTTA
TTTTTATTTTCCTATGGACTTGGTATTACATGTATAATAAATTAGAATAA
CCAGT
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protein sequence of SMED30016436-orf-1

>SMED30016436-orf-1 ID=SMED30016436-orf-1|Name=SMED30016436-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=574bp
MNLKLWITLYSYNGDFPGSLSFKANELFLVLRKENEYWFLVSEKEGTLGC
VPINYMKMIDMPEKKILKYIDKAIISLSQKSASIISRRDEIIRDLLEFKD
QTINRENNEVNVEKVIENNSCEKPTPPSLIPDGLAFMLTDIIRQSTKASH
KCSVKTLQILLEALKTSVPDLKMWTNSITNQLLNTSKFHLEKAFYNSGDW
NDLTELFDFFQQRKNDNQERSWSLHEDVNDLKIKFSTLLKILKTCNHSLV
ISFLEAYNYDPFLSLIELYQMEQRIVLRQLLLQIFIVCCEINKKSIVICL
QSILPLELVRDLMDTNINDKNFTYASLLLTILINGCDMMNIDLQERLNVE
FCVAMLYKLSEFHNTALDSSLSGKEESSCTFGEDSHEIFNFKDPIYMDDV
IVGFLLSFNKRFKNVKKNPIITSLQLKPECTRLFIEKLIRAFNRDYDPAL
TTSYIDDSEIENVQKSSSNSVRKILCDIHSSKKLADLIYRNDEDVIIDII
SRELCNLPANSTELSEYLMLLDLIVLNSDYLERGKYKSYDLKSALNILKN
DDINDFDKTLIDSILEKLDHTVI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR036028SH3-like_dom_sf
IPR001452SH3_domain
IPR018556DUF2013
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0008092cytoskeletal protein binding
GO:0017124SH3 domain binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005829cytosol
GO:0005882intermediate filament
Vocabulary: biological process
TermDefinition
GO:0006607NLS-bearing protein import into nucleus
GO:0007010cytoskeleton organization
GO:0007165signal transduction
GO:0010976positive regulation of neuron projection development
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001452SH3 domainSMARTSM00326SH3_2coord: 4..60
e-value: 1.2E-6
score: 38.1
IPR001452SH3 domainPFAMPF14604SH3_9coord: 9..56
e-value: 8.6E-9
score: 35.1
IPR001452SH3 domainPROSITEPS50002SH3coord: 1..61
score: 14.325
NoneNo IPR availableGENE3DG3DSA:2.30.30.40coord: 6..81
e-value: 1.4E-10
score: 42.7
NoneNo IPR availablePANTHERPTHR13357SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAINcoord: 34..570
IPR018556Domain of unknown function DUF2013PFAMPF09431DUF2013coord: 398..540
e-value: 1.5E-17
score: 64.1
IPR036028SH3-like domain superfamilySUPERFAMILYSSF50044SH3-domaincoord: 5..63