Piezo-type mechanosensitive ion channel component
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30016398 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 403.29 bits (1035), Expect = 1.155e-112 Identity = 221/593 (37.27%), Postives = 351/593 (59.19%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEAN---QSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARW---WEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
PIKQ F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KCVYF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S I + V N P++ + +I++GGY P+F ++++ LK + + +F+K + + + +L ++E D+T ++G+S+ +WTI+PPS +K+ +L S + + +R+ ++ + L +KN+ K I N S V I+ I+P ++ A + S+ L N ++++T+ + ++N ++ W + + Y N + L + +F+++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2195 PIKQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLNLTGNRIYNPNSQ-------ALELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2774 HSP 2 Score: 200.675 bits (509), Expect = 1.480e-50 Identity = 159/587 (27.09%), Postives = 290/587 (49.40%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYG--------NFANSSM---EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYK-LNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
+W + E H K + I++V + +V N + ++ P+ +L + + V + I++ KM+YQ++ + N+ NCS N N S+ ID +W+GL K ++ L+ +++ + + Y ++Y+ N P + IF ++ + + KY +N+ F K GLE F+ +V V R+D Y++++ L+ L +R +W Y FL ++ QY IC+G+PP C +YP N+I +WLY P++ V P P ++ DF+ + LQ Q+F+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++R + ++ YN VI K I + C ++ L CW++ F++ C ++G A+ C+ S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K +++++R++ +I+ RQ ++ K + L G+
Sbjct: 959 MWWILELHIIKIVSSYIIWVSVKEVSLFNYVFLISWAFALPYAKLRRLASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPFNELNKSLLYSAPIDPTEWVGLRKSSPLLVY-LRNNLLMLAILAFEVTIYRHQEYYRGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYFINYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITFQYFICIGIPPAPCRDYPWRFKGASFNDNII----KWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRS-YLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTL-VHNSCWLIQAFSLACT------VKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGE 1532 HSP 3 Score: 127.102 bits (318), Expect = 2.831e-28 Identity = 74/213 (34.74%), Postives = 113/213 (53.05%), Query Frame = 2
Query: 3527 RKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW-------------------------RDHSEFYKDIKISNEEEVNHIQPLKPQSAMR 4090
+K +D+ E++++ F + +F L + + SE CYF++I+NH++S ++++L P L+F W MLSVPRPS+ FW++ I YTE+ IV KY QF N V ++ P P I+G+EK Y + D+IQLL LF HRS LK +GLW RD S+ K I ++ E H+ + Q+A+R
Sbjct: 1911 KKMFHDDELEESEK--FYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNK-NVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKSINLAASVESVHVTFPEQQTAVR 2120
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 403.29 bits (1035), Expect = 1.208e-112 Identity = 221/593 (37.27%), Postives = 351/593 (59.19%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEAN---QSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARW---WEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
PIKQ F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KCVYF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S I + V N P++ + +I++GGY P+F ++++ LK + + +F+K + + + +L ++E D+T ++G+S+ +WTI+PPS +K+ +L S + + +R+ ++ + L +KN+ K I N S V I+ I+P ++ A + S+ L N ++++T+ + ++N ++ W + + Y N + L + +F+++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2170 PIKQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLNLTGNRIYNPNSQ-------ALELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2749 HSP 2 Score: 200.675 bits (509), Expect = 1.234e-50 Identity = 159/587 (27.09%), Postives = 290/587 (49.40%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYG--------NFANSSM---EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYK-LNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
+W + E H K + I++V + +V N + ++ P+ +L + + V + I++ KM+YQ++ + N+ NCS N N S+ ID +W+GL K ++ L+ +++ + + Y ++Y+ N P + IF ++ + + KY +N+ F K GLE F+ +V V R+D Y++++ L+ L +R +W Y FL ++ QY IC+G+PP C +YP N+I +WLY P++ V P P ++ DF+ + LQ Q+F+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++R + ++ YN VI K I + C ++ L CW++ F++ C ++G A+ C+ S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K +++++R++ +I+ RQ ++ K + L G+
Sbjct: 934 MWWILELHIIKIVSSYIIWVSVKEVSLFNYVFLISWAFALPYAKLRRLASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPFNELNKSLLYSAPIDPTEWVGLRKSSPLLVY-LRNNLLMLAILAFEVTIYRHQEYYRGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYFINYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITFQYFICIGIPPAPCRDYPWRFKGASFNDNII----KWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRS-YLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTL-VHNSCWLIQAFSLACT------VKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGE 1507 HSP 3 Score: 127.102 bits (318), Expect = 2.754e-28 Identity = 74/213 (34.74%), Postives = 113/213 (53.05%), Query Frame = 2
Query: 3527 RKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW-------------------------RDHSEFYKDIKISNEEEVNHIQPLKPQSAMR 4090
+K +D+ E++++ F + +F L + + SE CYF++I+NH++S ++++L P L+F W MLSVPRPS+ FW++ I YTE+ IV KY QF N V ++ P P I+G+EK Y + D+IQLL LF HRS LK +GLW RD S+ K I ++ E H+ + Q+A+R
Sbjct: 1886 KKMFHDDELEESEK--FYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNK-NVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKSINLAASVESVHVTFPEQQTAVR 2095
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 402.905 bits (1034), Expect = 1.451e-112 Identity = 221/593 (37.27%), Postives = 351/593 (59.19%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEAN---QSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARW---WEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
PIKQ F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KCVYF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S I + V N P++ + +I++GGY P+F ++++ LK + + +F+K + + + +L ++E D+T ++G+S+ +WTI+PPS +K+ +L S + + +R+ ++ + L +KN+ K I N S V I+ I+P ++ A + S+ L N ++++T+ + ++N ++ W + + Y N + L + +F+++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2121 PIKQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLNLTGNRIYNPNSQ-------ALELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2700 HSP 2 Score: 195.667 bits (496), Expect = 4.701e-49 Identity = 159/589 (26.99%), Postives = 290/589 (49.24%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIID--VHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYG--------NFANSSM---EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYK-LNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
+W + E H K + I++V + + V N + ++ P+ +L + + V + I++ KM+YQ++ + N+ NCS N N S+ ID +W+GL K ++ L+ +++ + + Y ++Y+ N P + IF ++ + + KY +N+ F K GLE F+ +V V R+D Y++++ L+ L +R +W Y FL ++ QY IC+G+PP C +YP N+I +WLY P++ V P P ++ DF+ + LQ Q+F+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++R + ++ YN VI K I + C ++ L CW++ F++ C ++G A+ C+ S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K +++++R++ +I+ RQ ++ K + L G+
Sbjct: 883 MWWILELHIIKIVSSYIIWVSVKEARVSLFNYVFLISWAFALPYAKLRRLASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPFNELNKSLLYSAPIDPTEWVGLRKSSPLLVY-LRNNLLMLAILAFEVTIYRHQEYYRGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYFINYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITFQYFICIGIPPAPCRDYPWRFKGASFNDNII----KWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRS-YLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTL-VHNSCWLIQAFSLACT------VKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGE 1458 HSP 3 Score: 127.102 bits (318), Expect = 2.882e-28 Identity = 74/213 (34.74%), Postives = 113/213 (53.05%), Query Frame = 2
Query: 3527 RKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW-------------------------RDHSEFYKDIKISNEEEVNHIQPLKPQSAMR 4090
+K +D+ E++++ F + +F L + + SE CYF++I+NH++S ++++L P L+F W MLSVPRPS+ FW++ I YTE+ IV KY QF N V ++ P P I+G+EK Y + D+IQLL LF HRS LK +GLW RD S+ K I ++ E H+ + Q+A+R
Sbjct: 1837 KKMFHDDELEESEK--FYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNK-NVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKSINLAASVESVHVTFPEQQTAVR 2046
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO1 (piezo type mechanosensitive ion channel component 1 [Source:HGNC Symbol;Acc:HGNC:28993]) HSP 1 Score: 357.836 bits (917), Expect = 1.270e-98 Identity = 217/596 (36.41%), Postives = 339/596 (56.88%), Query Frame = 2
Query: 4118 KQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKL-RSTESLKINMQAICERRSSDSKTTEKM-VRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQT-YLNLTLSMKKENEA------RWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
+ L++F+ + + K DVYA+MFL + +III G+++FG + + + ++ P F+ M++ QF +++DRAL+LRK V GK FQ+ V+ IH W+FF LP +T+R FN QL YF+KC+YFALS+YQ+R GYP RILGNFLT+ YN+ NL F+ + +PFL ELR VMDW+WTDT+++L WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ F W PL S + + V N PI+ T ++ +GGY PLF +++ ++ ++++ + ++ + D+ I+GSS +W I+PPS ++K +L T + + +R + T E +H + ++ L +E VV I +FP+++ A + L+ + + YL + + +++E A WW I E+ T C + L + IFS++VS G L + YGI+G+Y + + V + +R F+S+IS+ I EELP VDRIL L +I+LVRE + LEE+L AKLIFLYRS ETMIKWTR +
Sbjct: 1940 RPLRRFFHDILHTKYRAATDVYALMFLADVVDFIIIIFGFWAFGKHS-AATDITSSLSDDQVPEAFLVMLLIQFSTMVVDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSSWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQSVV-IPNLFPKYIRAPNGPEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVI-ELQECRTDC----------NLLPMVIFSDKVSPPSLGFL-AGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTREKE 2521 HSP 2 Score: 215.312 bits (547), Expect = 4.315e-55 Identity = 169/566 (29.86%), Postives = 293/566 (51.77%), Query Frame = 2
Query: 965 RLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSS----MEI---------IDNAKWLGLEK----LENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKP-KTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRID-VYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLN---VIP---KLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHK--DFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQH 2581
RL E H K + + V+V + +V MN++L+++ P+PR + V + I++ KM+YQ+K+ + +NC++ F NS+ EI +D A W G+ K L Q H+ +L+ V+ + Y + + Y+ P +F ++ LKY +NF F K GLE+ F+ V V R++ + +L ++ + R LW Y +FL + L QY++C+G+PP LCI+YP +P L +WLYLP++ +P +++DF+ + Q+QVF E+ ++ V LE + + +FI +S Y+D LK VF + +WL L ++F TG I++FGLGYLL F L G +L ++ + + ++ YN VI++K + L+ CVF+ ++T G CW++ LF++ C ++ + + ++ D +G+ WD VCFFF++LQR +F + +L V+ DL +SRG L N +KSI+ ++ EEK L +++R++++I +Q +H
Sbjct: 808 RLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCVIIVCKMLYQLKVVNPQEYSSNCTE--PFPNSTNLLPTEISQSLLYRGPVDPANWFGVRKGFPNLGYIQNHL---QVLLL--LVFEAIVYRRQEHYRRQHQLAPLPAQAVFASGTRQQLDQDLLGCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFLVTLHGCWLVAILTRRHRQAIARLWPNYCLFLALFLLYQYLLCLGMPPALCIDYPWRWSRAVPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGVNTDRLEPLRGEPNPVPNFIHCRS-YLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTALLQRDTRARLVLWDCLILYNVTVIISKNMLSLLACVFVEQMQT-GFCWVIQLFSLVCTVKGYYDPKEMMDRDQDCLLPVEEAGIIWDSVCFFFLLLQRRVFLSHYYLHVRADLQATALLASRGFALYNAANLKSIDFHRRIEEKSLAQLKRQMERIRAKQEKH 1364 HSP 3 Score: 113.235 bits (282), Expect = 4.887e-24 Identity = 59/144 (40.97%), Postives = 85/144 (59.03%), Query Frame = 2
Query: 3584 SRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNV-LPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSE 4012
+ + LL + + +SE CYF++I+NH+++ + SL P LVF W MLS+PRPSK FW+ I +TE+ +V KY+ QF N + + + P P ILG+EK+ Y D++QL+ LF HRS L GLW DH E
Sbjct: 1668 GQGRALRLLRAVYQCVAAHSELLCYFIIILNHMVTASAGSLVLPVLVFLWAMLSIPRPSKRFWMTAIVFTEIAVVVKYLFQFGFFPWNSHVVLRRYENKPYFPPRILGLEKTDGYIKYDLVQLMALFFHRSQLLCYGLW-DHEE 1810
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 211.46 bits (537), Expect = 7.135e-54 Identity = 104/220 (47.27%), Postives = 151/220 (68.64%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSE 4771
PIKQ F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KCVYF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE
Sbjct: 2170 PIKQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESE 2385 HSP 2 Score: 201.06 bits (510), Expect = 9.471e-51 Identity = 159/587 (27.09%), Postives = 290/587 (49.40%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYG--------NFANSSM---EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYK-LNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
+W + E H K + I++V + +V N + ++ P+ +L + + V + I++ KM+YQ++ + N+ NCS N N S+ ID +W+GL K ++ L+ +++ + + Y ++Y+ N P + IF ++ + + KY +N+ F K GLE F+ +V V R+D Y++++ L+ L +R +W Y FL ++ QY IC+G+PP C +YP N+I +WLY P++ V P P ++ DF+ + LQ Q+F+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++R + ++ YN VI K I + C ++ L CW++ F++ C ++G A+ C+ S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K +++++R++ +I+ RQ ++ K + L G+
Sbjct: 934 MWWILELHIIKIVSSYIIWVSVKEVSLFNYVFLISWAFALPYAKLRRLASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPFNELNKSLLYSAPIDPTEWVGLRKSSPLLVY-LRNNLLMLAILAFEVTIYRHQEYYRGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYFINYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITFQYFICIGIPPAPCRDYPWRFKGASFNDNII----KWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRS-YLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTL-VHNSCWLIQAFSLACT------VKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGE 1507 HSP 3 Score: 156.762 bits (395), Expect = 3.212e-37 Identity = 97/309 (31.39%), Postives = 167/309 (54.05%), Query Frame = 2
Query: 4961 PLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQ---SSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARW---WEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
P+F ++++ LK + + +F+K + + + +L ++E D+T ++G+S+ +WTI+PPS +K+ +L S + + +R+ ++ + L +KN+ K I N S V I+ I+P ++ A + S+ L N ++++T+ + ++N ++ W + + Y N + L + +F+++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2387 PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLNLTGNRIYNPNSQ-------ALELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2686 HSP 4 Score: 127.487 bits (319), Expect = 2.646e-28 Identity = 74/213 (34.74%), Postives = 113/213 (53.05%), Query Frame = 2
Query: 3527 RKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW-------------------------RDHSEFYKDIKISNEEEVNHIQPLKPQSAMR 4090
+K +D+ E++++ F + +F L + + SE CYF++I+NH++S ++++L P L+F W MLSVPRPS+ FW++ I YTE+ IV KY QF N V ++ P P I+G+EK Y + D+IQLL LF HRS LK +GLW RD S+ K I ++ E H+ + Q+A+R
Sbjct: 1886 KKMFHDDELEESEK--FYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNK-NVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKSINLAASVESVHVTFPEQQTAVR 2095
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 361.303 bits (926), Expect = 3.264e-104 Identity = 274/935 (29.30%), Postives = 437/935 (46.74%), Query Frame = 2
Query: 3347 FIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGKEIEKIVKDGRKSVSEDKEEKNKQD----VFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLP-VPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDH-----------------SEFYKDIKISNEEEVNHIQ--------------PLKPQSAMRTG-IKFRNPIKQ-----LKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENN-----LKSLPKDTFDKMKECYKNFSPPTD------------YLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNT----KQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKR---TL--SEATALLKDHNQTYLNLTLSMKKENEAR-WWEIQEIVAGETYCSNEK--IPKQSHSN--------------------LTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHR-VLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
I S + +V N+ RE+ L +EK+ +KS + KL +I V + + + K + V + +S LL + +++ CYF IM +++G L++LP P + FWG LS PRPSK FW+ +ITYTE VIV K++CQF + N + EH++DP++L + G+ + ++A+ D++ L LF HR L+ GLW+D S+ KI+ E +V Q P P + + PI + + +F ++ + K D+Y IMF + LI+ GY +FG G G+ +D +K ++ PV + M++ + IIIDRAL+LRK V GK ++Q+ + +H W+F LP +T+R S Q LY IK YF +S++Q+R+GYP +GN LT +Y N+I FK++M IPFL+ELR +DW WTDTS+ LF + +E+ + IF +KC R+ E YP RG + KY +G ++ I + PL L S + + P + T IS+ GY PL+ ++ +N L + D + + + D YL + D+ + S+ W I+ S + KL S +N + E ++H+ + LD + + A+ + + + I P F+ + TL S ++ D N +N T M+K +EAR W++ + + NEK I H L V F +R + +F G+I +Y + I V R ++R ++ + ELP+ D +L + +IYLVRE K F LE+ L AKLIFL+RS T+I+WTR +K
Sbjct: 109 MIASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKL-TDIRSAVDLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLSRNTS--VNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGD-PGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPR-IN-TTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 1034
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 358.992 bits (920), Expect = 3.332e-100 Identity = 272/934 (29.12%), Postives = 437/934 (46.79%), Query Frame = 2
Query: 3350 IGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGKEIEKIVKDGR----KSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLP-VPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDH-----------------SEFYKDIKISNEEEVNHIQ--------------PLKPQSAMRTG-IKFRNPIKQ-----LKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENN-----LKSLPKDTFDKMKECYKNFSPPTD------------YLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNT----KQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKR-----TLSEATALLKDHNQTYLNLTLSMKKENEAR-WWEIQEIVAGETYCSNEK--IPKQSHSN--------------------LTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHR-VLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
I S + +V N+ RE+ L +EK+ +KS + KL +I V +S ++ ++ + V + +S LL + +++ CYF IM +++G L++LP P + FWG LS PRPSK FW+ +ITYTE VIV K++CQF + N + EH++DP++L + G+ + ++A+ D++ L LF HR L+ GLW+D S+ KI+ E +V Q P P + + PI + + +F ++ + K D+Y IMF + LI+ GY +FG G G+ +D +K ++ PV + M++ + IIIDRAL+LRK V GK ++Q+ + +H W+F LP +T+R S Q LY IK YF +S++Q+R+GYP +GN LT +Y N+I FK++M IPFL+ELR +DW WTDTS+ LF + +E+ + IF +KC R+ E YP RG + KY +G ++ I + PL L S + + P + T IS+ GY PL+ ++ +N L + D + + + D YL + D+ + S+ W I+ S + KL S +N + E ++H+ + LD + + A+ + + + I P F+ + S ++ D N +N T M+K +EAR W++ + + NEK I H L V F +R + +F G+I +Y + I V R ++R ++ + ELP+ D +L + +IYLVRE K F LE+ L AKLIFL+RS T+I+WTR +K
Sbjct: 776 IASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKL-TDIRSAVDLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLSRNTS--VNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGD-PGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPR-IN-TTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 1700 HSP 2 Score: 160.614 bits (405), Expect = 5.766e-39 Identity = 164/613 (26.75%), Postives = 283/613 (46.17%), Query Frame = 2
Query: 911 TATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSAS--IVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEK-LENFQLHILKWTAI--LVGCAVWHIVRYHQMQF-YKLNLDQKPKTSVI--FQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNV-IPK--------LRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRS-------CNVILYYNFLVILTKCIFQLMGCVFMNLLKTKG-----LCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQR---QAQHGKPELN----EHYLVMRSGDYYLF 2641
T +KL L T +WR +E H +K + ++I +++A+ I L++++ + P + +LF+C+ + + KMIYQ+ I L+ + N S I +W GL+K +E + + + I ++ A IV Y Q + L L + + V F S++N +++ +++GF K GLE++ I + R+D + + L+LF + KR +W+ Y+I++ IL P+Q+ VGLPP CIEYP + IP L L L Y V+ ++ DF + Q VF +R+ D+ + ++ DFI K SYVDY K VF++ +W+TL G+ +LF LGY++ LW G + + S +RS N +L Y I K Q+ GCVF++ G LC + LF+I C+N ++ + + + + +DV+ F++ Q IF + F ++ + ++RGA L N I K +++Q + ++ + N I R+ + I +R Q + G E + + R+GDYY+F
Sbjct: 68 TLVKKLHKLANQTIELLWRFFEVHISKIVFVIIAIFIANNINALYIPLVILLSLAICLPS-AADGIFSLFMCAYLFLVALSKMIYQLDIVPE---LSQIDRGVGADNCSHGNISMPEWFGLKKEVEGTEPIYMLFGVIVSIIALAFQSIVIYRQRHYRASLGLPESMRAKVFPDFHHSHFDRSLKN---AIQFLIDYGFYKFGLEITMIAIGIDIFNRMDALAAIQCFWLVLFALNKRVFVRRIWVFYVIYMAILYPLQFFSYVGLPPDSCIEYPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAYLIGDFFVLLLASCQLAVF---RREGEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYV--MNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCVNNECHVLKELEDFSKACAVETKEGNIGFDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRRRTEAIRERYQKQIERGAAERDFEPVTYGHAKRAGDYYMF 668
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 358.992 bits (920), Expect = 3.332e-100 Identity = 272/934 (29.12%), Postives = 437/934 (46.79%), Query Frame = 2
Query: 3350 IGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGKEIEKIVKDGR----KSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLP-VPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDH-----------------SEFYKDIKISNEEEVNHIQ--------------PLKPQSAMRTG-IKFRNPIKQ-----LKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENN-----LKSLPKDTFDKMKECYKNFSPPTD------------YLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNT----KQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKR-----TLSEATALLKDHNQTYLNLTLSMKKENEAR-WWEIQEIVAGETYCSNEK--IPKQSHSN--------------------LTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHR-VLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
I S + +V N+ RE+ L +EK+ +KS + KL +I V +S ++ ++ + V + +S LL + +++ CYF IM +++G L++LP P + FWG LS PRPSK FW+ +ITYTE VIV K++CQF + N + EH++DP++L + G+ + ++A+ D++ L LF HR L+ GLW+D S+ KI+ E +V Q P P + + PI + + +F ++ + K D+Y IMF + LI+ GY +FG G G+ +D +K ++ PV + M++ + IIIDRAL+LRK V GK ++Q+ + +H W+F LP +T+R S Q LY IK YF +S++Q+R+GYP +GN LT +Y N+I FK++M IPFL+ELR +DW WTDTS+ LF + +E+ + IF +KC R+ E YP RG + KY +G ++ I + PL L S + + P + T IS+ GY PL+ ++ +N L + D + + + D YL + D+ + S+ W I+ S + KL S +N + E ++H+ + LD + + A+ + + + I P F+ + S ++ D N +N T M+K +EAR W++ + + NEK I H L V F +R + +F G+I +Y + I V R ++R ++ + ELP+ D +L + +IYLVRE K F LE+ L AKLIFL+RS T+I+WTR +K
Sbjct: 776 IASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKL-TDIRSAVDLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLSRNTS--VNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGD-PGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPR-IN-TTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 1700 HSP 2 Score: 160.614 bits (405), Expect = 5.766e-39 Identity = 164/613 (26.75%), Postives = 283/613 (46.17%), Query Frame = 2
Query: 911 TATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSAS--IVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEK-LENFQLHILKWTAI--LVGCAVWHIVRYHQMQF-YKLNLDQKPKTSVI--FQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNV-IPK--------LRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRS-------CNVILYYNFLVILTKCIFQLMGCVFMNLLKTKG-----LCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQR---QAQHGKPELN----EHYLVMRSGDYYLF 2641
T +KL L T +WR +E H +K + ++I +++A+ I L++++ + P + +LF+C+ + + KMIYQ+ I L+ + N S I +W GL+K +E + + + I ++ A IV Y Q + L L + + V F S++N +++ +++GF K GLE++ I + R+D + + L+LF + KR +W+ Y+I++ IL P+Q+ VGLPP CIEYP + IP L L L Y V+ ++ DF + Q VF +R+ D+ + ++ DFI K SYVDY K VF++ +W+TL G+ +LF LGY++ LW G + + S +RS N +L Y I K Q+ GCVF++ G LC + LF+I C+N ++ + + + + +DV+ F++ Q IF + F ++ + ++RGA L N I K +++Q + ++ + N I R+ + I +R Q + G E + + R+GDYY+F
Sbjct: 68 TLVKKLHKLANQTIELLWRFFEVHISKIVFVIIAIFIANNINALYIPLVILLSLAICLPS-AADGIFSLFMCAYLFLVALSKMIYQLDIVPE---LSQIDRGVGADNCSHGNISMPEWFGLKKEVEGTEPIYMLFGVIVSIIALAFQSIVIYRQRHYRASLGLPESMRAKVFPDFHHSHFDRSLKN---AIQFLIDYGFYKFGLEITMIAIGIDIFNRMDALAAIQCFWLVLFALNKRVFVRRIWVFYVIYMAILYPLQFFSYVGLPPDSCIEYPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAYLIGDFFVLLLASCQLAVF---RREGEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYV--MNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCVNNECHVLKELEDFSKACAVETKEGNIGFDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRRRTEAIRERYQKQIERGAAERDFEPVTYGHAKRAGDYYMF 668
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 358.992 bits (920), Expect = 3.841e-100 Identity = 272/934 (29.12%), Postives = 437/934 (46.79%), Query Frame = 2
Query: 3350 IGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGKEIEKIVKDGR----KSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLP-VPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDH-----------------SEFYKDIKISNEEEVNHIQ--------------PLKPQSAMRTG-IKFRNPIKQ-----LKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENN-----LKSLPKDTFDKMKECYKNFSPPTD------------YLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNT----KQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKR-----TLSEATALLKDHNQTYLNLTLSMKKENEAR-WWEIQEIVAGETYCSNEK--IPKQSHSN--------------------LTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHR-VLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
I S + +V N+ RE+ L +EK+ +KS + KL +I V +S ++ ++ + V + +S LL + +++ CYF IM +++G L++LP P + FWG LS PRPSK FW+ +ITYTE VIV K++CQF + N + EH++DP++L + G+ + ++A+ D++ L LF HR L+ GLW+D S+ KI+ E +V Q P P + + PI + + +F ++ + K D+Y IMF + LI+ GY +FG G G+ +D +K ++ PV + M++ + IIIDRAL+LRK V GK ++Q+ + +H W+F LP +T+R S Q LY IK YF +S++Q+R+GYP +GN LT +Y N+I FK++M IPFL+ELR +DW WTDTS+ LF + +E+ + IF +KC R+ E YP RG + KY +G ++ I + PL L S + + P + T IS+ GY PL+ ++ +N L + D + + + D YL + D+ + S+ W I+ S + KL S +N + E ++H+ + LD + + A+ + + + I P F+ + S ++ D N +N T M+K +EAR W++ + + NEK I H L V F +R + +F G+I +Y + I V R ++R ++ + ELP+ D +L + +IYLVRE K F LE+ L AKLIFL+RS T+I+WTR +K
Sbjct: 758 IASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKL-TDIRSAVDLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLSRNTS--VNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGD-PGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPR-IN-TTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 1682 HSP 2 Score: 160.999 bits (406), Expect = 4.954e-39 Identity = 166/619 (26.82%), Postives = 286/619 (46.20%), Query Frame = 2
Query: 911 TATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSAS--IVILKMIYQIKIFQTFNWLT------NCSQYGNFANSSMEIIDNAKWLGLEK-LENFQLHILKWTAI--LVGCAVWHIVRYHQMQF-YKLNLDQKPKTSVI--FQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNV-IPK--------LRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRS-------CNVILYYNFLVILTKCIFQLMGCVFMNLLKTKG-----LCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQR---QAQHGKPELN----EHYLVMRSGDYYLF 2641
T +KL L T +WR +E H +K + ++I +++A+ I L++++ + P + +LF+C+ + + KMIYQ+ I + + NCS +GN I +W GL+K +E + + + I ++ A IV Y Q + L L + + V F S++N +++ +++GF K GLE++ I + R+D + + L+LF + KR +W+ Y+I++ IL P+Q+ VGLPP CIEYP + IP L L L Y V+ ++ DF + Q VF +R+ D+ + ++ DFI K SYVDY K VF++ +W+TL G+ +LF LGY++ LW G + + S +RS N +L Y I K Q+ GCVF++ G LC + LF+I C+N ++ + + + + +DV+ F++ Q IF + F ++ + ++RGA L N I K +++Q + ++ + N I R+ + I +R Q + G E + + R+GDYY+F
Sbjct: 50 TLVKKLHKLANQTIELLWRFFEVHISKIVFVIIAIFIANNINALYIPLVILLSLAICLPS-AADGIFSLFMCAYLFLVALSKMIYQLDIVPELSQIDRGVGADNCS-HGN--------ISMPEWFGLKKEVEGTEPIYMLFGVIVSIIALAFQSIVIYRQRHYRASLGLPESMRAKVFPDFHHSHFDRSLKN---AIQFLIDYGFYKFGLEITMIAIGIDIFNRMDALAAIQCFWLVLFALNKRVFVRRIWVFYVIYMAILYPLQFFSYVGLPPDSCIEYPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAYLIGDFFVLLLASCQLAVF---RREGEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYV--MNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCVNNECHVLKELEDFSKACAVETKEGNIGFDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRRRTEAIRERYQKQIERGAAERDFEPVTYGHAKRAGDYYMF 650
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Match: pezo-1 (Piezo-type mechanosensitive ion channel component [Source:UniProtKB/TrEMBL;Acc:A0A061AE33]) HSP 1 Score: 358.221 bits (918), Expect = 7.113e-100 Identity = 272/934 (29.12%), Postives = 437/934 (46.79%), Query Frame = 2
Query: 3350 IGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGKEIEKIVKDGR----KSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLP-VPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDH-----------------SEFYKDIKISNEEEVNHIQ--------------PLKPQSAMRTG-IKFRNPIKQ-----LKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENN-----LKSLPKDTFDKMKECYKNFSPPTD------------YLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNT----KQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKR-----TLSEATALLKDHNQTYLNLTLSMKKENEAR-WWEIQEIVAGETYCSNEK--IPKQSHSN--------------------LTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHR-VLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
I S + +V N+ RE+ L +EK+ +KS + KL +I V +S ++ ++ + V + +S LL + +++ CYF IM +++G L++LP P + FWG LS PRPSK FW+ +ITYTE VIV K++CQF + N + EH++DP++L + G+ + ++A+ D++ L LF HR L+ GLW+D S+ KI+ E +V Q P P + + PI + + +F ++ + K D+Y IMF + LI+ GY +FG G G+ +D +K ++ PV + M++ + IIIDRAL+LRK V GK ++Q+ + +H W+F LP +T+R S Q LY IK YF +S++Q+R+GYP +GN LT +Y N+I FK++M IPFL+ELR +DW WTDTS+ LF + +E+ + IF +KC R+ E YP RG + KY +G ++ I + PL L S + + P + T IS+ GY PL+ ++ +N L + D + + + D YL + D+ + S+ W I+ S + KL S +N + E ++H+ + LD + + A+ + + + I P F+ + S ++ D N +N T M+K +EAR W++ + + NEK I H L V F +R + +F G+I +Y + I V R ++R ++ + ELP+ D +L + +IYLVRE K F LE+ L AKLIFL+RS T+I+WTR +K
Sbjct: 802 IASALDLCSVTLNKLCREHRYVGFVLSKEKQKLKSGHSESLSNTSRKL-TDIRSAVDLPSLQLVQSANDVEKMETAVSVDWQQKSSATRLLNAVVNCIGAHTDILCYFFAIMTQVMTGGLITLPLPLMSLFWGNLSNPRPSKFFWVTMITYTECVIVIKFVCQFAFMPYNSITWRTEHQMDPMSLDKLFGVSQRDSFALWDIVLLFSLFFHRYMLRKLGLWKDANLTDTFTLKEEPRSASGSDTGSPKKIAQEPKVVVTQSDTLEGTSGGEIVIPSDPNAVSNMEELDCEPPIPEKQSGPIGRFIHQLFHPKFRYIRDLYPIMFGIDVICFLIMTFGYSAFGEG--GSGNVLDDVKASRIPVTLVVMLVGMTLAIIIDRALYLRKSVVGKLIYQVLMIAFLHIWVFLVLPNMTRRSAISNHVAQALYVIKSCYFLVSAWQIRNGYPELCIGNLLTHSYGMTNMIAFKVFMNIPFLFELRTAIDWTWTDTSMPLFDFFNMENFYAHIFNIKCARQFEAAYPAPRGIPKGKLVKYMMGFPIIIGVVIFIFSPLLLWSLLNQIGTISMPEKVTLRISIEGYPPLYEMEAQGSNHDNAELGMIKPDQLASLNQALTDSYTTRDTNSILRSRMSVSYLKGYTYEDILIVRFRPESEIYWPISQDSRNAMIDKLSRNTS--VNFEVSLEFTRPYDPNENAALKHSKSWLVPISLDMTIRAKIQSALRGD-PGHPILIPQSIPAFIQVPNQGELTLPTSIGNTIINDGNPR-IN-TTGMEKSDEARAWFDSLTLNLEQGKSQNEKMWIATSEHPGDQNAKLWIKTANTTYSGRPYLQVVGFIDRAFPSFLAKVFKG-GVIAVYLSVILVVGRGLVRGIFTTSPSTVMFTELPNADHLLKICLDIYLVREAKDFMLEQDLFAKLIFLFRSPATLIEWTRMSK 1726 HSP 2 Score: 152.525 bits (384), Expect = 1.561e-36 Identity = 155/591 (26.23%), Postives = 272/591 (46.02%), Query Frame = 2
Query: 911 TATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSAS--IVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEK-LENFQLHILKWTAI--LVGCAVWHIVRYHQMQF-YKLNLDQKPKTSVI--FQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNV-IPK--------LRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQ-----KSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKG-----LCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQR---QAQHGKPE 2593
T +KL L T +WR +E H +K + ++I +++A+ I L++++ + P + +LF+C+ + + KMIYQ+ I L+ + N S I +W GL+K +E + + + I ++ A IV Y Q + L L + + V F S++N +++ +++GF K GLE++ I + R+D + + L+LF + KR +W+ Y+I++ IL P+Q+ VGLPP CIEYP + IP L L L Y V+ ++ DF + Q VF +R+ D+ + ++ DFI K SYVDY K VF++ +W+TL G+ +LF LGY++ LW G + + + ++ N +L Y I K Q+ GCVF++ G LC + LF+I C+N ++ + + + + +DV+ F++ Q IF + F ++ + ++RGA L N I K +++Q + ++ + N I R+ + I +R Q + G E
Sbjct: 68 TLVKKLHKLANQTIELLWRFFEVHISKIVFVIIAIFIANNINALYIPLVILLSLAICLPS-AADGIFSLFMCAYLFLVALSKMIYQLDIVPE---LSQIDRGVGADNCSHGNISMPEWFGLKKEVEGTEPIYMLFGVIVSIIALAFQSIVIYRQRHYRASLGLPESMRAKVFPDFHHSHFDRSLKN---AIQFLIDYGFYKFGLEITMIAIGIDIFNRMDALAAIQCFWLVLFALNKRVFVRRIWVFYVIYMAILYPLQFFSYVGLPPDSCIEYPWSYWIPSYSDDARFNLSYLLNLSIYGVNWPSAYLIGDFFVLLLASCQLAVF---RREGEDNDSIYNDGNFVIKPENPQYDFIDTKKSYVDYFKSFVFHYGHWITLMSTLAAGIAGTSLFALGYIIFTLTMLWSGNNLYVMNSTLRSFEHTLKRWNALLGYTLFTITMKVCLQIFGCVFLSWFDQSGGWGKTLCIVRQLFSITCVNNECHVLKELEDFSKACAVETKEGNIGFDVIALSFLVFQIRIFHSWYFQHCMVEYRSEVILANRGAVLKNQLIEKEMKEQNEQQKAKFNDIRRRTEAIRERYQKQIERGAAE 648
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335183) HSP 1 Score: 482.256 bits (1240), Expect = 5.063e-138 Identity = 316/953 (33.16%), Postives = 498/953 (52.26%), Query Frame = 2
Query: 3188 PIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKN--VIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGKEIEKIVKDGRKSVSE-DKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW--------------------RDHSE--FYKDIKISNEEEVNHIQPLKPQSAMRTGIKF-RNPIKQLK---------KFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPG-TDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDEN-----------DKKNLLKAIEANQSS--------YVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEAR--WWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFS---NYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTR 5866
P PS R Q+S T+ + E V +G + S E+F +I+L F + +LT+ N ++R Y R L EKK +K S+ + + +K +S E + EE+N +R +LIS + ++ CY ++ +N +++ +L+SLP P +VF WG LS+PRP+K FW+ LI YT+ +++ K I QF LI N +P PL I G+E YAI D+I LL LFLHR LK GLW RD S+ D + N++ + Q+++ +F + I QL+ KF+ + ++ DVYA+MFLC+F +++ G+ +FG T+S ++ NK P+PF+ M++ QF+ I+IDRAL+LRK + K +F F VI IH W+FF +P +T+R FNS PP + Y IKC Y LSSYQ++SGYP RILGNF T+ ++ N+I FK+YM IPFLYELR ++DW+ D+++ +F W+++ED+F I++++C R+SE ++P +R + SK +GG ++ IC WGPL L + N P + SI +G Y P+ Y + +++ + + + +M Y ++ ++A DV + + G+S +W I PP ++L LR+ +LK R++ +K ++ V + LDE+ + + ++ I +N ++ VV I + P+F+ + ++L + Y L + M ++NE WWEI++ Y NE + K ++SN T I +D F FS GIIG+Y ++ +A R +++F + I E+LP+VDR+L L +IYLVRE F LEE L AKL+FLYRS ET+IKWTR
Sbjct: 1570 PPPSTGLGREQTSKETSDSKSKME-----VDSGEVTAKDSDEDFDTNPIIRLLEGF----LVTLTIRLNRFSRNYRFVNRILAGEKKTLKES--SSLNRLGLSSAAAMFHFLKSNLESAGEFNLEEEN---FAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKS-RLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPI-YTTNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAP-AKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRDYCNDTFY--NETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2500 HSP 2 Score: 204.142 bits (518), Expect = 6.002e-52 Identity = 193/670 (28.81%), Postives = 316/670 (47.16%), Query Frame = 2
Query: 806 AVQLQVTLRPTSIRVSGLLTFYLSEFIRDVNNMVFTATEKLKS----LYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVIL-KMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQ---LHILKWTAILVGCAVWH-IVRYHQMQF-YKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIP---KLRQWLYLPN-YKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSD------SHKLVKQRLLE----GFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCIN---------PMSWEIRGIHGKNADKQCSSVASG--LHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQA-------------QHGKP----------ELNEHYLVMRSGDYYLF 2641
A L+ + P++ G T +F V ++V + K+K+ ++ + WR E H K + I + +V ++II + V+G + V+++ L ++++L KMIYQI+ +L++ SQ+ N S +NA+W+GL K + + +L+ I + H ++ Q+Q K+ P T ++F + + ++ L+KY LNFGF K G+E+S I V R D+ ++VY L L++ L+L+R C +W + F I + QY++ VGLPP C+ +P + P +++W LP + VP K++ DF+ + + Q +F +E+R S+ S++ V + + F H DF S +Y D LK+ V YW TLA++F G L LGYL+ AFI+LW G + ++I +L +N IL K FQ+ GC+FM L TK CW+V + I C + P E+ G +C + L WD +CF FII Q IF + F + D N +SRGA +I K I + E++ L++I+RK+++I Q +HG P E+ H R+GDYY+F
Sbjct: 754 AGSLRKSQGPSAEAAPGATT----DFETSVRDLVRISFRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIE------YLSH-SQH-NVVCSDNRTANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPFGEGIQRWAMLPGALHFNHVP-KLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTH-DFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQL-TKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPG-----ECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMF 1403
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335181) HSP 1 Score: 478.789 bits (1231), Expect = 6.660e-137 Identity = 316/960 (32.92%), Postives = 499/960 (51.98%), Query Frame = 2
Query: 3188 PIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKN--VIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHV------LSTFIEIDEKLGKEIEKIVKDGRKSVSEDKEEKN--KQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW--------------------RDHSE--FYKDIKISNEEEVNHIQPLKPQSAMRTGIKF-RNPIKQLK---------KFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPG-TDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDEN-----------DKKNLLKAIEANQSS--------YVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEAR--WWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFS---NYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTR 5866
P PS R Q+S T+ + E V +G + S E+F +I+L F + +LT+ N ++R Y R L EKK +K LS+ + L +E+ ++ E N +++ +R +LIS + ++ CY ++ +N +++ +L+SLP P +VF WG LS+PRP+K FW+ LI YT+ +++ K I QF LI N +P PL I G+E YAI D+I LL LFLHR LK GLW RD S+ D + N++ + Q+++ +F + I QL+ KF+ + + K DVYA+MFLC+F +++ G+ +FG T+S ++ NK P+PF+ M++ QF+ I+IDRAL+LRK + K +F F VI IH W+FF +P +T+R FNS PP + Y IKC Y LSSYQ++SGYP RILGNF T+ ++ N+I FK+YM IPFLYELR ++DW+ D+++ +F W+++ED+F I++++C R+SE ++P +R + SK +GG ++ IC WGPL L + N P + SI +G Y P+ Y + +++ + + + +M Y ++ ++A DV + + G+S +W I PP ++L LR+ +LK R++ +K ++ V + LDE+ + + ++ I +N ++ VV I + P+F+ + ++L + Y L + M ++NE WWEI++ Y NE + K ++SN T I +D F FS GIIG+Y ++ +A R +++F + I E+LP+VDR+L L +IYLVRE F LEE L AKL+FLYRS ET+IKWTR
Sbjct: 1596 PPPSTGLGREQTSKETSDSKSKME-----VDSGEVTAKDSDEDFDTNPIIRLLEGF----LVTLTIRLNRFSRNYRFVNRILAGEKKTLKESSSLNRLGLSSAAAMFHFLKSNLERKQSINSSPPAKGAGEFNLEEENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVH-KSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPI-YTTNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAP-AKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRDYCNDTFY--NETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2538 HSP 2 Score: 203.756 bits (517), Expect = 7.350e-52 Identity = 188/647 (29.06%), Postives = 308/647 (47.60%), Query Frame = 2
Query: 875 SEFIRDVNNMVFTATEKLKS----LYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVIL-KMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQ---LHILKWTAILVGCAVWH-IVRYHQMQF-YKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIP---KLRQWLYLPN-YKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSD------SHKLVKQRLLE----GFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCIN---------PMSWEIRGIHGKNADKQCSSVASG--LHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQA-------------QHGKP----------ELNEHYLVMRSGDYYLF 2641
++F V ++V + K+K+ ++ + WR E H K + I + +V ++II + V+G + V+++ L ++++L KMIYQI+ +L++ SQ+ N S +NA+W+GL K + + +L+ I + H ++ Q+Q K+ P T ++F + + ++ L+KY LNFGF K G+E+S I V R D+ ++VY L L++ L+L+R C +W + F I + QY++ VGLPP C+ +P + P +++W LP + VP K++ DF+ + + Q +F +E+R S+ S++ V + + F H DF S +Y D LK+ V YW TLA++F G L LGYL+ AFI+LW G + ++I +L +N IL K FQ+ GC+FM L TK CW+V + I C + P E+ G +C + L WD +CF FII Q IF + F + D N +SRGA +I K I + E++ L++I+RK+++I Q +HG P E+ H R+GDYY+F
Sbjct: 866 TDFETSVRDLVRISFRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIE------YLSH-SQH-NVVCSDNRTANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPFGEGIQRWAMLPGALHFNHVP-KLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTH-DFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQL-TKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPG-----ECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMF 1496
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335182) HSP 1 Score: 463.766 bits (1192), Expect = 4.641e-132 Identity = 282/825 (34.18%), Postives = 446/825 (54.06%), Query Frame = 2
Query: 3563 KQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW--------------------RDHSE--FYKDIKISNEEEVNHIQPLKPQSAMRTGIKF-RNPIKQLK---------KFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPG-TDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDEN-----------DKKNLLKAIEANQSS--------YVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEAR--WWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFS---NYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTR 5866
+++ +R +LIS + ++ CY ++ +N +++ +L+SLP P +VF WG LS+PRP+K FW+ LI YT+ +++ K I QF LI N +P PL I G+E YAI D+I LL LFLHR LK GLW RD S+ D + N++ + Q+++ +F + I QL+ KF+ + ++ DVYA+MFLC+F +++ G+ +FG T+S ++ NK P+PF+ M++ QF+ I+IDRAL+LRK + K +F F VI IH W+FF +P +T+R FNS PP + Y IKC Y LSSYQ++SGYP RILGNF T+ ++ N+I FK+YM IPFLYELR ++DW+ D+++ +F W+++ED+F I++++C R+SE ++P +R + SK +GG ++ IC WGPL L + N P + SI +G Y P+ Y + +++ + + + +M Y ++ ++A DV + + G+S +W I PP ++L LR+ +LK R++ +K ++ V + LDE+ + + ++ I +N ++ VV I + P+F+ + ++L + Y L + M ++NE WWEI++ Y NE + K ++SN T I +D F FS GIIG+Y ++ +A R +++F + I E+LP+VDR+L L +IYLVRE F LEE L AKL+FLYRS ET+IKWTR
Sbjct: 1702 EENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKS-RLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPI-YTTNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAP-AKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRDYCNDTFY--NETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2518 HSP 2 Score: 209.92 bits (533), Expect = 9.040e-54 Identity = 185/625 (29.60%), Postives = 307/625 (49.12%), Query Frame = 2
Query: 875 SEFIRDVNNMVFTATEKLKS----LYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVIL-KMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQ---LHILKWTAILVGCAVWH-IVRYHQMQF-YKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIP---KLRQWLYLPN-YKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSD------SHKLVKQRLLE----GFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCIN---------PMSWEIRGIHGKNADKQCSSVASG--LHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKP-ELNEHYLVMRSGDYYLF 2641
++F V ++V + K+K+ ++ + WR E H K + I + +V ++II + V+G + V+++ L ++++L KMIYQI+ +L++ SQ+ N S +NA+W+GL K + + +L+ I + H ++ Q+Q K+ P T ++F + + ++ L+KY LNFGF K G+E+S I V R D+ ++VY L L++ L+L+R C +W + F I + QY++ VGLPP C+ +P + P +++W LP + VP K++ DF+ + + Q +F +E+R S+ S++ V + + F H DF S +Y D LK+ V YW TLA++F G L LGYL+ AFI+LW G + ++I +L +N IL K FQ+ GC+FM L TK CW+V + I C + P E+ G +C + L WD +CF FII Q IF + F + D N +SRGA +I K I + E++ L++I+RK+++I Q + +P + H+ R+GDYY+F
Sbjct: 795 TDFETSVRDLVRISFRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIE------YLSH-SQH-NVVCSDNRTANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPFGEGIQRWAMLPGALHFNHVP-KLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTH-DFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQL-TKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPG-----ECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDATRAGDYYMF 1403
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335177) HSP 1 Score: 463.766 bits (1192), Expect = 4.933e-132 Identity = 283/825 (34.30%), Postives = 446/825 (54.06%), Query Frame = 2
Query: 3563 KQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW--------------------RDHSE--FYKDIKISNEEEVNHIQPLKPQSAMRTGIKF-RNPIKQLK---------KFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPG-TDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDEN-----------DKKNLLKAIEANQSS--------YVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEAR--WWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFS---NYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTR 5866
+++ +R +LIS + ++ CY ++ +N +++ +L+SLP P +VF WG LS+PRP+K FW+ LI YT+ +++ K I QF LI N +P PL I G+E YAI D+I LL LFLHR LK GLW RD S+ D + N++ + Q+++ +F + I QL+ KF+ + + K DVYA+MFLC+F +++ G+ +FG T+S ++ NK P+PF+ M++ QF+ I+IDRAL+LRK + K +F F VI IH W+FF +P +T+R FNS PP + Y IKC Y LSSYQ++SGYP RILGNF T+ ++ N+I FK+YM IPFLYELR ++DW+ D+++ +F W+++ED+F I++++C R+SE ++P +R + SK +GG ++ IC WGPL L + N P + SI +G Y P+ Y + +++ + + + +M Y ++ ++A DV + + G+S +W I PP ++L LR+ +LK R++ +K ++ V + LDE+ + + ++ I +N ++ VV I + P+F+ + ++L + Y L + M ++NE WWEI++ Y NE + K ++SN T I +D F FS GIIG+Y ++ +A R +++F + I E+LP+VDR+L L +IYLVRE F LEE L AKL+FLYRS ET+IKWTR
Sbjct: 1837 EENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVH-KSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPI-YTTNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAP-AKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRDYCNDTFY--NETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2653 HSP 2 Score: 204.912 bits (520), Expect = 3.772e-52 Identity = 193/670 (28.81%), Postives = 316/670 (47.16%), Query Frame = 2
Query: 806 AVQLQVTLRPTSIRVSGLLTFYLSEFIRDVNNMVFTATEKLKS----LYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVIL-KMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQ---LHILKWTAILVGCAVWH-IVRYHQMQF-YKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIP---KLRQWLYLPN-YKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSD------SHKLVKQRLLE----GFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCIN---------PMSWEIRGIHGKNADKQCSSVASG--LHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQA-------------QHGKP----------ELNEHYLVMRSGDYYLF 2641
A L+ + P++ G T +F V ++V + K+K+ ++ + WR E H K + I + +V ++II + V+G + V+++ L ++++L KMIYQI+ +L++ SQ+ N S +NA+W+GL K + + +L+ I + H ++ Q+Q K+ P T ++F + + ++ L+KY LNFGF K G+E+S I V R D+ ++VY L L++ L+L+R C +W + F I + QY++ VGLPP C+ +P + P +++W LP + VP K++ DF+ + + Q +F +E+R S+ S++ V + + F H DF S +Y D LK+ V YW TLA++F G L LGYL+ AFI+LW G + ++I +L +N IL K FQ+ GC+FM L TK CW+V + I C + P E+ G +C + L WD +CF FII Q IF + F + D N +SRGA +I K I + E++ L++I+RK+++I Q +HG P E+ H R+GDYY+F
Sbjct: 754 AGSLRKSQGPSAEAAPGATT----DFETSVRDLVRISFRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIE------YLSH-SQH-NVVCSDNRTANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPFGEGIQRWAMLPGALHFNHVP-KLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTH-DFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQL-TKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPG-----ECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMF 1403
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Match: Piezo (gene:FBgn0264953 transcript:FBtr0335180) HSP 1 Score: 463.766 bits (1192), Expect = 5.323e-132 Identity = 283/825 (34.30%), Postives = 446/825 (54.06%), Query Frame = 2
Query: 3563 KQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW--------------------RDHSE--FYKDIKISNEEEVNHIQPLKPQSAMRTGIKF-RNPIKQLK---------KFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPG-TDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDEN-----------DKKNLLKAIEANQSS--------YVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEAR--WWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFS---NYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTR 5866
+++ +R +LIS + ++ CY ++ +N +++ +L+SLP P +VF WG LS+PRP+K FW+ LI YT+ +++ K I QF LI N +P PL I G+E YAI D+I LL LFLHR LK GLW RD S+ D + N++ + Q+++ +F + I QL+ KF+ + + K DVYA+MFLC+F +++ G+ +FG T+S ++ NK P+PF+ M++ QF+ I+IDRAL+LRK + K +F F VI IH W+FF +P +T+R FNS PP + Y IKC Y LSSYQ++SGYP RILGNF T+ ++ N+I FK+YM IPFLYELR ++DW+ D+++ +F W+++ED+F I++++C R+SE ++P +R + SK +GG ++ IC WGPL L + N P + SI +G Y P+ Y + +++ + + + +M Y ++ ++A DV + + G+S +W I PP ++L LR+ +LK R++ +K ++ V + LDE+ + + ++ I +N ++ VV I + P+F+ + ++L + Y L + M ++NE WWEI++ Y NE + K ++SN T I +D F FS GIIG+Y ++ +A R +++F + I E+LP+VDR+L L +IYLVRE F LEE L AKL+FLYRS ET+IKWTR
Sbjct: 1772 EENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVH-KSRLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPI-YTTNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAP-AKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRDYCNDTFY--NETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2588 HSP 2 Score: 204.142 bits (518), Expect = 6.331e-52 Identity = 193/670 (28.81%), Postives = 316/670 (47.16%), Query Frame = 2
Query: 806 AVQLQVTLRPTSIRVSGLLTFYLSEFIRDVNNMVFTATEKLKS----LYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVIL-KMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQ---LHILKWTAILVGCAVWH-IVRYHQMQF-YKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIP---KLRQWLYLPN-YKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSD------SHKLVKQRLLE----GFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCIN---------PMSWEIRGIHGKNADKQCSSVASG--LHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQA-------------QHGKP----------ELNEHYLVMRSGDYYLF 2641
A L+ + P++ G T +F V ++V + K+K+ ++ + WR E H K + I + +V ++II + V+G + V+++ L ++++L KMIYQI+ +L++ SQ+ N S +NA+W+GL K + + +L+ I + H ++ Q+Q K+ P T ++F + + ++ L+KY LNFGF K G+E+S I V R D+ ++VY L L++ L+L+R C +W + F I + QY++ VGLPP C+ +P + P +++W LP + VP K++ DF+ + + Q +F +E+R S+ S++ V + + F H DF S +Y D LK+ V YW TLA++F G L LGYL+ AFI+LW G + ++I +L +N IL K FQ+ GC+FM L TK CW+V + I C + P E+ G +C + L WD +CF FII Q IF + F + D N +SRGA +I K I + E++ L++I+RK+++I Q +HG P E+ H R+GDYY+F
Sbjct: 773 AGSLRKSQGPSAEAAPGATT----DFETSVRDLVRISFRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIE------YLSH-SQH-NVVCSDNRTANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPFGEGIQRWAMLPGALHFNHVP-KLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTH-DFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQL-TKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPG-----ECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMF 1422
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: LO018508.1 (pep chromosome:GRCz11:2:54327160:54353625:1 gene:ENSDARG00000112723.1 transcript:ENSDART00000182320.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:LO018508.1) HSP 1 Score: 405.216 bits (1040), Expect = 6.192e-124 Identity = 234/598 (39.13%), Postives = 353/598 (59.03%), Query Frame = 2
Query: 4097 IKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRST-ESLKINMQAICERR-SSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEA----RWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
++F PI+Q F+ + + + + DVY +MFL + +II+ G+++FG G + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP IT+R+F+ QL YF+KC+YF LS+YQ+R GYP RILGNFLT++YNY NL F+ + IPFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S + + V N P+E + S+++GG P+F +++N++KS+ + +L S+ D+T ++GSS+ +WTI+PPS E LK L T E + +R S +K M ++ +LD+ +K L + SS V I IFPR++ A + S A + + +N+ Y+++TL + K+N + WW + + +G +P + S L ++I S++VS G L + YGI+G+Y + + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 20 VEFYQPIRQ---FFYNLVHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGK-HQGGADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVVGKVIFQVILVFGIHFWMFFILPGITERRFSQNTIAQLWYFVKCIYFGLSAYQIRCGYPTRILGNFLTKSYNYANLFLFQGFRLIPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLEVSVSLTLGGLQPIFTMSAQQNHIKSVTGNAI--------------MFLESYFPEDLTIAHLEGSSNSLWTISPPSKENLKNMLNDTREPFPLTFTWSIQRNLSLGAKAETAMGKY--FIELDDETRKGLTDQL--GNSSQRVTIKKIFPRYIRA--PSDSNAKPIDQLYNE-YMDITLFLNKKNSSEGVQEWWIVNQTDSG-------PLPGLNGSGLQIYIISDQVSPPSLGFL-AGYGIMGLYMSVVLVIGKFVREFFSGISHTIMFEELPNVDRILKLCTDIFLVRETGELDLEEDLYAKLIFLYRSPETMIKWTRE 584
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-131119-76]) HSP 1 Score: 406.757 bits (1044), Expect = 2.801e-121 Identity = 223/604 (36.92%), Postives = 354/604 (58.61%), Query Frame = 2
Query: 4082 AMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERR-SSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKK-----ENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHN 5872
++T + PI+Q F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P F+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+R+F+ QL YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IFVLKCWR SE YP RG ++ KY +GG+++ W PL S + + V N P++ + +I++GG+ P+F +++N LK L + F Y +L ++ A DVT ++GSS+ +WTI+PPS + L L + + M +R S +K+ M +H LD ++ L+ + +++ V+ I+ +FP F+ A + ++ L + + Y ++ L +++ E+ WW + E+ + + +Q + L +++FS++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 261 TVKTVLDVYIPIRQ---FFYSLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYLNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKELTESDFKNFINSYNYVPSAMQFLEAYRAEDVTVAELEGSSNSLWTISPPSRKNLMDVLSKEDQFPVTMTWSIQRNLSLGAKSEFAMDKHVT--YLDIKTRQELIALLNGTRNTPVL-IEQVFPCFIRAPSDSNAKPIEQLYE-DGVYKSIQLDLERSANSSEDLQEWWIVDELRSAQK--------QQREAGLQLYVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 847 HSP 2 Score: 117.087 bits (292), Expect = 9.931e-26 Identity = 61/144 (42.36%), Postives = 84/144 (58.33%), Query Frame = 2
Query: 3575 FRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDH 4006
F RS+ + L S V + +S+ CY ++I+NH++S ++ +L P L+F W MLSVPRPSK FW+ I YTE+ IV KY QF N + + P P I+G+EK Y D++QLL LF HRS LK GLW +
Sbjct: 13 FYRSQPQLLQLCYSLYNVLVSHSQMVCYLVIILNHMISASVATLVLPVLIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFN-QSIEVDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCYGLWDEE 155
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-131119-76]) HSP 1 Score: 404.06 bits (1037), Expect = 3.871e-113 Identity = 222/594 (37.37%), Postives = 350/594 (58.92%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERR-SSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKK-----ENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHN 5872
PI+Q F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P F+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+R+F+ QL YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IFVLKCWR SE YP RG ++ KY +GG+++ W PL S + + V N P++ + +I++GG+ P+F +++N LK L + F Y +L ++ A DVT ++GSS+ +WTI+PPS + L L + + M +R S +K+ M +H LD ++ L+ + +++ V+ I+ +FP F+ A + ++ L + + Y ++ L +++ E+ WW + E+ + + +Q + L +++FS++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2044 PIRQ---FFYSLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYLNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKELTESDFKNFINSYNYVPSAMQFLEAYRAEDVTVAELEGSSNSLWTISPPSRKNLMDVLSKEDQFPVTMTWSIQRNLSLGAKSEFAMDKHVT--YLDIKTRQELIALLNGTRNTPVL-IEQVFPCFIRAPSDSNAKPIEQLYE-DGVYKSIQLDLERSANSSEDLQEWWIVDELRSAQK--------QQREAGLQLYVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2620 HSP 2 Score: 209.534 bits (532), Expect = 1.558e-53 Identity = 165/588 (28.06%), Postives = 287/588 (48.81%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSS-MEI---------IDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKL-NLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQME-----KRKKSDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHG--KNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
IW + E H K + I++V + +V N + ++ PF + + + V + I++ KM+YQ+ + NCS N+ + M++ +D A W+GL K L L+ +++ + + Y FY++ N P T IF + + + KY +N+ F K GLE F+ V V R+D +++++ L+ + +R +W Y FL LL QY++C+G+PP C +YP NVI +WLY P++ P +L DF+ + LQ +VF+ E + D+ ++ + F Q + DFI +S Y+D LK +VF + +W L IIF TG I++F +GYL+ F +L G +L+ KS++ + ++ YN VI K I + C ++ L CW++ LF++ C I+G + A+KQC S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K ++ ++R++ +I+ RQ + + + L SG+
Sbjct: 811 IWWILELHIIKIVSSYIIWVSVKEVSLFNYVFVVSWAFALPFCQFRPLASSVCTVWTCIIIVCKMLYQLTSISPAAYARNCSMPDNYTEAQRMDMAKSLLYIGPVDPANWIGLRKFSPL-LEYLRNNLLMLALLAFEVTIYRHQDFYRMKNNITPPVTRTIFHNITRQHLDDGIVNCAKYFINYFFYKFGLETCFLLAVNVIGQRMDFFAMLHAFGLIAVMYQRRRKAIAHVWSKYCCFLACLLSFQYLMCIGIPPAACTDYPWRRSSSSMDSNVI----KWLYFPDFHTKPNSLFLLYDFMLLLCASLQGRVFEEECVSPVQLLAGDNVEICRDLDAATFSQHNPVPDFIHCRS-YLDMLKVMVFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLIFGGELLLKPIKSILHYWDFLIAYNVFVITMKNILSIAACGYIKAL-VANHCWLIQLFSLACT------IKGYSKPEQQANKQCELPSDEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRSSQLLASRGAELFQATIVKAVKARIEEEKKSMDLLKRQMDRIKSRQQKFKRGKERMLSLAQESGE 1385 HSP 3 Score: 117.472 bits (293), Expect = 1.754e-25 Identity = 65/169 (38.46%), Postives = 91/169 (53.85%), Query Frame = 2
Query: 3560 NKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEEVNHIQP 4066
+ + F RS+ + L S V + +S+ CY ++I+NH++S ++ +L P L+F W MLSVPRPSK FW+ I YTE+ IV KY QF N + + P P I+G+EK Y D++QLL LF HRS LK GLW +EEE + P
Sbjct: 1781 EQSERFYRSQPQLLQLCYSLYNVLVSHSQMVCYLVIILNHMISASVATLVLPVLIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFN-QSIEVDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCYGLW-------------DEEEPRSVSP 1935
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:ZFIN;Acc:ZDB-GENE-041111-255]) HSP 1 Score: 357.836 bits (917), Expect = 7.454e-99 Identity = 215/601 (35.77%), Postives = 342/601 (56.91%), Query Frame = 2
Query: 4106 RNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKL-KVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQT-YLNLTLSMKKE------NEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTR---HN 5872
+N + F+ + + + DVYA+MFL + +III G+++FG + + A + ++ P F+ M++ QF +IIDRAL+LRK + GK +FQ+ V IH W+FF LP +T+R FN QL YF KC+YF LS+YQ+R GYP RILGNFLT+ +N+ NL F+ + +PFL ELR VMDW+WTDT+++L +WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ F W PL S + + V N P++ T ++ +GGY PLF ++ +++ + ++++ + + ++ + D+ +I+GSS VW I+PPS ++L K L ST + + + +R T E + +N + L ++ V + +FP ++ A ++ L D ++ + ++T+S+ +E WW+I +A C K+S + L + IF+++VS G L + YGI+G+Y + + V + +R F+S+IS+ I EELP DRIL L +I+LVRE LEE+L +KLIFLYRS ETMIKWTR HN
Sbjct: 1849 KNVYRPTWDFFQNILHAEYRASTDVYALMFLTDVVDFIIIIFGFWAFGKHSAAADIASS-LSEDQVPEAFLVMLLIQFSTMIIDRALYLRKSILGKLIFQVILVFGIHLWMFFILPAVTERMFNHNSVAQLWYFFKCIYFTLSAYQIRCGYPTRILGNFLTKKFNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKRIVKYGMGGLIILFLICIIWFPLLFISLVKSVVGVVNHPVDVTVTVKLGGYEPLFTMSVQQQSIQPFTESRYNQLNNQFSKNAVAMQFITMYSYEDIVTANIEGSSGSVWRISPPSRQELIKELLSSTGDMTLRLDWNFQRDLGKGGTVENTFDKHSISLAPKNPVRADLASLLLGTRKDPVHVPHMFPNYIRAPSGAEAKPVMQLFDGDEEGFQDVTVSLMREASVNTTGAQEWWDIS--IAD---C------KESCNVLPMIIFNDKVSPPSLGFL-AGYGIMGLYVSVVLVIGKFVRGFFSEISHSIMFEELPCADRILKLCMDIFLVRETGELELEEELYSKLIFLYRSPETMIKWTREKNHN 2436 HSP 2 Score: 231.491 bits (589), Expect = 3.537e-60 Identity = 168/638 (26.33%), Postives = 316/638 (49.53%), Query Frame = 2
Query: 893 VNNMVFTATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVM--VTALFVCSASIVILKMIYQIKIFQTFNWLTNCS---------QYGNFANSSM--EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV--LWLPYMIFLGILLPVQYVICVGLPPGLCIEYP------LNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK---SDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNA--DKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELN---------------------------EHYLVMRSGDYYLF 2641
V + + + K T Q IWR+ E H K + +V+V +++ AMN++L+++ P+ R + ++ ++VC I++ KM+YQ+ + + NC+ + NS++ +D A W G+ K + ++ +L+ V HQ+ Y+ P VIF + + + +KY LN+ F K GLE+ F+ TV V R++ + ++ L+ ++++R N+ +W Y +FL + + QYV+CVG+PP LCI+YP + + L +W+YLP++ P +++DF+ + Q+ VF EK+++ +E + +FI+ +S Y+D K +VF + +W L+++F TG I++FGLGYL+ F +L G +L ++ + + ++ YN VI++K I ++ CVF+ ++ K CW++ LF++ C ++G + + +K CS +G+ WD +CFFF++LQR +F + FL V DL + +SRG L I+K++ +++E K + +++ +K+I +Q ++ + +H V+ SG+YY+F
Sbjct: 737 VMDRLMVLSRKFSDTLTHVQSFIWRVLELHIVKIVAFFVVWVALLEPSAMNLVLVVLWSFAMPYGRFRAMASCLSTIWVCV--IIVCKMLYQLSVVNPAEYSNNCTAPMVNETSLEPDEVLNSTLYRASVDPASWFGVRKDDTVLGYVKDHLLVLMLLVFEATVYRHQIHHYRQQQRSPPPIPVIFPQATRDTLDQGLLHCIKYMLNYSFYKFGLEICFLMTVNVIGQRMN-FLVIIHGCWLVAIMVRRRRANIATIWSKYCLFLVVFMIYQYVLCVGIPPALCIDYPWRWRSTVTIHSALVKWMYLPDFYTVPNSKNLISDFLLLMCASQQWTVFDNEKKEEWMVMGGENRDNPDPMENMLFNPAPNFINCRS-YLDMAKILVFRYMFWFVLSVVFVTGATRISVFGLGYLMACFFFLLFGTKLLTKPSRTRLVMWDCLIIYNVAVIISKNILSILACVFVMEMQ-KNFCWVIQLFSLVCT------VKGYYDPESVCNKDCSLPVEEAGIIWDSICFFFLLLQRRVFLSFYFLHVSADLQASARQASRGFELFRASIIKNMHFHQQAERKSIQQLKESMKRIRGKQQKYKDGRITSDIEEQPSEQKKETKLSKSKSWQYPWVDHATVLHSGEYYMF 1363 HSP 3 Score: 122.865 bits (307), Expect = 4.141e-27 Identity = 65/160 (40.62%), Postives = 94/160 (58.75%), Query Frame = 2
Query: 3575 FRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNV---LPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEE 4045
F S+++ LL + V +SE CYF++++N+L++ +++SL P LVF W MLSVPRPSK FW+ I YTE+++V KY+ QF N L + E + P P ILG+EK+ Y D++QLL LF HRS L+ GLW + +S E
Sbjct: 1604 FYSSQNRLLKLLFALYNVLAAHSELVCYFIIVLNNLVTASVISLVLPVLVFLWAMLSVPRPSKRFWMTAIIYTEVMVVVKYLFQFGFFPWNTEYELKLNEDK--PFFPPRILGLEKTDNYIRYDLLQLLVLFFHRSLLQRYGLWDQEGPLEEKSDLSPAE 1761
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Match: si:dkey-11f4.7 (si:dkey-11f4.7 [Source:ZFIN;Acc:ZDB-GENE-070912-361]) HSP 1 Score: 234.958 bits (598), Expect = 6.871e-69 Identity = 124/285 (43.51%), Postives = 188/285 (65.96%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICF-WGPLTLSSFIGTTF-VKNPPIECTFSISVGGYS 4960
PI+Q F+ + + + + DVYA+MFL + +III GY++FG + + + + ++ P F+ M++ QF +I+DRAL+LRK + GK VFQ+ V IH W+FF LP +T+R+FN QL YF+KC+YF LS+YQ++ GYP R+LGNFLT+N+NY NL F+ + +PFL ELR VMDW+WTDT+++L +W+ VED++ IF+LKCWR +E +YP RG ++ KY++GG ++ F IC W PL S + + V N P++ + +S+ GY
Sbjct: 8 PIRQ---FFYDIIHPEYSPVCDVYALMFLIDVVNFIIIIFGYWAFGKHS-AAADITESLSEDQVPEAFLVMLLIQFSTMIVDRALYLRKTLLGKCVFQVVLVFGIHFWMFFILPGVTERRFNRNRVAQLWYFVKCIYFGLSAYQIKCGYPNRVLGNFLTKNHNYFNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSNWICVEDIYANIFILKCWREAEKKYPHRRGQRKKKVVKYTMGGFII-FALICIVWFPLLFMSLVKSVAGVTNQPLDVSIQLSILGYE 287
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 491.5 bits (1264), Expect = 6.944e-142 Identity = 284/820 (34.63%), Postives = 444/820 (54.15%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW-------------------------RDHSEFYKDIKISNEEEVNHIQPLKPQSAMR-----------------TGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEA----RWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
EE + F ++ + L+ + + SE CYF++I+NH++S ++++L P L+F W MLSVPRPSK FW+ I YTE+ IV KY QF N V + P P I+GIEK Y D++QLL LF HRS LK +GLW RD K + ++ E H+ + ++A+R + ++ PI+Q F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P F+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S I + V N P++ + +I++GGY P+F +++N L+ L + F + YK +P +L S+ D+T ++G+S+ +WTI+PP S + E++++ + + ++L E Y + + +R L++ +NQ ++N+++ ++KEN + WW + + S+++ K+ L +++FS++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 1228 EELEDSEKFYTTQPRPLQLIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNK-NVDYTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLWDEDDVTEKATDKDDTDGEISEASGRRDSVGSLKSVNLAASVESVHVHFPEEKTAIRRKSTSSGSQISRRSSYSSILQIYVPIRQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPP---------------------------SRTMMIERLIQEPDFTAVISWSIRSLGAKAEVTGEKYTISLAG-------QTRRELADMM-----NNQEFVNISVLLRKENTSEGVREWWVVNQ--------SHKEFIKK--DGLELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 1992 HSP 2 Score: 164.081 bits (414), Expect = 1.331e-39 Identity = 146/532 (27.44%), Postives = 250/532 (46.99%), Query Frame = 2
Query: 950 QPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNC---------SQYGNFANSSM---EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKL-NLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYP-----LNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGL--CWMVSLFAIQCINPMSWEIRG--IHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSR 2458
Q +W L E H K + I+++ I +V +N + + P+ + + + V + I+I KM+YQ+ + +NC ++ NSS+ +D + W+GL+K L L+ +++ + + Y ++Y+L N P T IF ++ + + KY +N+ F K GLE F+ +V V R+D +++V+ L L L +R W Y FL ++ QY IC+G+PP C +YP N + +WLY P++ V P P ++ DF+ + LQ +VF+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ + ++R + ++ YN VI K N+L L CW++ F++ C ++G I D Q S +G+ WD +CF F++LQR +F + FL V D+ +SR
Sbjct: 555 QVFVWWLLELHMIKIVSSYIIWLTIKEVSLLNYVFFIAWAFALPYSQFRPLASSVCTVWTCVIIICKMLYQLASIDPATFSSNCLMPQLNETTARNQTELNSSVLYNSSVDPSNWVGLKKSTPL-LAYLRNNLLMLAMLAFEVTIYRHQEYYRLRNNLTTPATKTIFHDITRLHLDDGLINSAKYFVNYFFYKFGLETCFLLSVNVIGQRMDFFAMVHALWLFGVLYRRRRKAIAETWHRYCCFLACIMAFQYFICIGIPPAACKDYPWRQPGANFNSNIIKWLYFPDFIVRPSPLFLVYDFLLLLCASLQREVFEEENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIYCRS-YLDMGKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIRIILRYWDWLIAYNVFVITMK-----------NVLSVSVLFHCWLIQAFSLSC------TVKGYFIPQNTPDCQLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKSSQILASR 1067
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 491.5 bits (1264), Expect = 1.190e-141 Identity = 284/820 (34.63%), Postives = 444/820 (54.15%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW-------------------------RDHSEFYKDIKISNEEEVNHIQPLKPQSAMR-----------------TGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEA----RWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
EE + F ++ + L+ + + SE CYF++I+NH++S ++++L P L+F W MLSVPRPSK FW+ I YTE+ IV KY QF N V + P P I+GIEK Y D++QLL LF HRS LK +GLW RD K + ++ E H+ + ++A+R + ++ PI+Q F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P F+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S I + V N P++ + +I++GGY P+F +++N L+ L + F + YK +P +L S+ D+T ++G+S+ +WTI+PP S + E++++ + + ++L E Y + + +R L++ +NQ ++N+++ ++KEN + WW + + S+++ K+ L +++FS++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 1302 EELEDSEKFYTTQPRPLQLIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNK-NVDYTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLWDEDDVTEKATDKDDTDGEISEASGRRDSVGSLKSVNLAASVESVHVHFPEEKTAIRRKSTSSGSQISRRSSYSSILQIYVPIRQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPP---------------------------SRTMMIERLIQEPDFTAVISWSIRSLGAKAEVTGEKYTISLAG-------QTRRELADMM-----NNQEFVNISVLLRKENTSEGVREWWVVNQ--------SHKEFIKK--DGLELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2066 HSP 2 Score: 165.622 bits (418), Expect = 4.391e-40 Identity = 146/532 (27.44%), Postives = 250/532 (46.99%), Query Frame = 2
Query: 950 QPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNC---------SQYGNFANSSM---EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKL-NLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYP-----LNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGL--CWMVSLFAIQCINPMSWEIRG--IHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSR 2458
Q +W L E H K + I+++ I +V +N + + P+ + + + V + I+I KM+YQ+ + +NC ++ NSS+ +D + W+GL+K L L+ +++ + + Y ++Y+L N P T IF ++ + + KY +N+ F K GLE F+ +V V R+D +++V+ L L L +R W Y FL ++ QY IC+G+PP C +YP N + +WLY P++ V P P ++ DF+ + LQ +VF+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ + ++R + ++ YN VI K N+L L CW++ F++ C ++G I D Q S +G+ WD +CF F++LQR +F + FL V D+ +SR
Sbjct: 568 QVFVWWLLELHMIKIVSSYIIWLTIKEVSLLNYVFFIAWAFALPYSQFRPLASSVCTVWTCVIIICKMLYQLASIDPATFSSNCLMPQLNETTARNQTELNSSVLYNSSVDPSNWVGLKKSTPL-LAYLRNNLLMLAMLAFEVTIYRHQEYYRLRNNLTTPATKTIFHDITRLHLDDGLINSAKYFVNYFFYKFGLETCFLLSVNVIGQRMDFFAMVHALWLFGVLYRRRRKAIAETWHRYCCFLACIMAFQYFICIGIPPAACKDYPWRQPGANFNSNIIKWLYFPDFIVRPSPLFLVYDFLLLLCASLQREVFEEENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIYCRS-YLDMGKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIRIILRYWDWLIAYNVFVITMK-----------NVLSVSVLFHCWLIQAFSLSC------TVKGYFIPQNTPDCQLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKSSQILASR 1080
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: PIEZO2 (piezo-type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:100492729]) HSP 1 Score: 476.863 bits (1226), Expect = 3.371e-137 Identity = 286/804 (35.57%), Postives = 444/804 (55.22%), Query Frame = 2
Query: 3521 DGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW--RDHSEFYKDIKISNEEEVN------------HIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTN-TKQLDENDKKNLLKAIEAN--QSSYVVQIDAIFPRFLTAYKRTLSEAT--ALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHN 5872
D +S D++ ++ + F ++ + L+ + + SE CYF++I+NH++S ++++L P L+F W MLSVPRPSK FW+ I YTE+ IV KY QF N V + P P I+GIEK Y D++QLL LF HRS LK +GLW D +E D K + E++ +I P ++ + PI+Q F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P F+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S I + V N P++ + +I++GGY P+F +++N L+ L + F + YK +P +L S+ D+T ++G+S+ +WTI+PP S + E++++ + T + + ++ ++ ++ N S I I+P L A ++ LL+ N + E WW + + S+++ K+ L +++FS++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 1187 DNLMVLSPDEKLEDSEK-FYTTQPRPLQLIYALYNTLVARSEMVCYFVIILNHMISASMITLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPWNK-NVDYTKDKPYFPPNIMGIEKKEGYVHYDLVQLLALFFHRSILKCHGLWDEDDVTEKATD-KDDTDGEISEASGRRDSFFILYILCFFPSRILQIYV----PIRQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERKFSQNTVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVTNKPLDVSITITLGGYQPIFTMSAQQNQLQGLNDNEFKHLHNIYKGNTPAMQFLESYMQEDITIAGLEGNSNSLWTISPP---------------------------SRTMMIERLIQEPDFTAVISWSIRRYIISSLFYNLPNSFSYRPIFHIYPLCLKAPSDVTAKPILHVLLRKENTS----------EGVREWWVVNQ--------SHKEFIKK--DGLELWVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 1931 HSP 2 Score: 173.326 bits (438), Expect = 2.427e-42 Identity = 146/530 (27.55%), Postives = 253/530 (47.74%), Query Frame = 2
Query: 950 QPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNC---------SQYGNFANSSM---EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKL-NLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYP-----LNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRG--IHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSR 2458
Q +W L E H K + I+++ I +V +N + + P+ + + + V + I+I KM+YQ+ + +NC ++ NSS+ +D + W+GL+K L L+ +++ + + Y ++Y+L N P T IF ++ + + KY +N+ F K GLE F+ +V V R+D +++V+ L L L +R W Y FL ++ QY IC+G+PP C +YP N + +WLY P++ V P P ++ DF+ + LQ +VF+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ + ++R + ++ YN VI K + + C ++ L K CW++ F++ C ++G I D Q S +G+ WD +CF F++LQR +F + FL V D+ +SR
Sbjct: 483 QVFVWWLLELHMIKIVSSYIIWLTIKEVSLLNYVFFIAWAFALPYSQFRPLASSVCTVWTCVIIICKMLYQLASIDPATFSSNCLMPQLNETTARNQTELNSSVLYNSSVDPSNWVGLKKSTPL-LAYLRNNLLMLAMLAFEVTIYRHQEYYRLRNNLTTPATKTIFHDITRLHLDDGLINSAKYFVNYFFYKFGLETCFLLSVNVIGQRMDFFAMVHALWLFGVLYRRRRKAIAETWHRYCCFLACIMAFQYFICIGIPPAACKDYPWRQPGANFNSNIIKWLYFPDFIVRPSPLFLVYDFLLLLCASLQREVFEEENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIYCRS-YLDMGKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIRIILRYWDWLIAYNVFVITMKNVLSIGACGYIEYL-IKDSCWLIQAFSLSC------TVKGYFIPQNTPDCQLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKSSQILASR 1003
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: chordc1 (cysteine and histidine rich domain containing 1 [Source:Xenbase;Acc:XB-GENE-962949]) HSP 1 Score: 465.692 bits (1197), Expect = 7.370e-133 Identity = 284/822 (34.55%), Postives = 447/822 (54.38%), Query Frame = 2
Query: 3545 DKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPV-PEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWR----DHSEFYKDIKISNEEEVNHIQPLKPQSAMRTGIK----------------------------FRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTES-----LKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLK-DHNQTYLNLTLSMKKENEA---------RWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWT 5863
D E ++ F +S+S+ LL++ +SE CYF++I+N+++S +L+SL P L+F WGMLS+ +PSK FW+ I +TE+++V KY+ QF N + + P P +LG+EKS +Y D+IQLL LF HRS L GLW D E ++ E+ Q L+P + ++ RN + +K F+ + + K DVYA MFL + +II+ G+++FG + + A + ++ P F+ M++ QF ++IDRAL+LRK V GK +FQ+ VI IH W+FF LP +T+R FN QL YF+KC+YFALS+YQ+R GYP RILGNFLT+ YN+ NL F+ + +PFL ELR VMDW+WTDT+++L +WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ F W PL S + + V N PI+ T + +GGY PLF +++ +++ ++ + ++ ++ + D+ I+GSS VW I+PPS E+++ +L++ S + Q + + T+EK + + + +LL+ + V I +FP+++ A + L+ D ++YL++ + + + A WW I + + + + L + IF+++VS G L + YGI+G+Y + + V + +R F+S+IS+ I EELP VDRIL L +IY+VRE LEE+L AKLIFLYRS ETMIKWT
Sbjct: 1348 DFPELSESQHFFQSQSRILRLLLALYNFVAAHSELLCYFIIILNNMVSASLISLFLPILIFLWGMLSIHKPSKRFWMTAIIFTEVMVVIKYLFQFGFFPWNNYTILVRNEGKPFFPPRVLGLEKSDSYIKYDLIQLLMLFFHRSLLMSYGLWDRKDLDLEERTPGKDKGSKTEIQASQDLEPAGGSSSSLRQRKRKESQGSVQERGAESNWTCAVQFTSLRNIYQPVKAFFHDILHTKNRAATDVYAFMFLADVVDFVIIVFGFWAFGKHSAAADIASS-LSDDQVPEAFLVMVLIQFSTMVIDRALYLRKTVLGKLIFQVILVIGIHVWMFFILPAVTERMFNQNTVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIIVFLICIIWFPLLFMSLVRSVVGVVNHPIDVTVTFKLGGYEPLFTMSAQQQSIQPFTPQQYEALTYEFERQPTAMQFITLYSYEDIVTARIEGSSGSVWGISPPSREQMRKELQNGSSDITLRFTWDFQRDLAKGGTVEHTSEKHTKDLEPGSQERMELADLLQGVRDTP----VSIQHLFPKYIRAPNGPEANPVKQLQPDEEESYLDVEVQLNRMRVAEGNSTSSFVEWWVI----------TLKDCEGEDCNILPMVIFNDKVSPPSLGFL-AGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIYVVRERGELELEEELYAKLIFLYRSPETMIKWT 2153 HSP 2 Score: 207.223 bits (526), Expect = 9.911e-53 Identity = 160/539 (29.68%), Postives = 276/539 (51.21%), Query Frame = 2
Query: 923 KLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQ---------YGNFANSSM--EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFI-CTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV--LWLPYMIFLGILLPVQYVICVGLPPGLCIEYP------LNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK--SDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGK---NADKQCSSVA--SGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSR 2458
K L Q +WRL E H K + + V+V + +V MN + +++ PF R + + ++ I++ KM+YQ+ + + +NC+Q NS++ E ID A W G+ K +I IL+ IV HQ + K +KP +F +V + +KY +N+ F K GLE+S C ++ C R++ + +++ L+ ++ +R N+ LW Y +FL L QY+IC+G+PP LCI+YP + V L +WLYLP++ +P +++DFV I V Q++VF EK+++ + + + V++ + + +FI+ +S Y+D +K VF + +W L ++F TG I++FGLGYL+ F L G +L K+ + + ++ YN VIL+K + L+ CVF+ ++T CW++ LF++ C ++G + + D+ CS +G+ WD +CF F++LQR +F + F V LDL + +SR
Sbjct: 568 KFSELLHRLQVFLWRLLELHVLKLVALYSVWVALQEVSVMNFLFVVLWAFAMPFSRFQHMASCLCTIWTSIIIVCKMLYQLTVVNPLEYSSNCTQPLLNNTSLLEDEILNSTLYREPIDPANWFGIRKGYPNLGYIQNHLQILLLLVFEAIVYRHQEFYRKQYQLEKPHIQAVFPDVYREHLDQGLFSCIKYFINYSFYKFGLEVSSQECDIL--CFRMN-FMVIFHGCWLIVILTRRQRVNIAKLWPKYCVFLIFFLLWQYMICLGIPPVLCIDYPWRWDTFVPVNSALIKWLYLPDFYTTPKSVNLISDFVLLIGVAQQWKVFINEKKEEWYTMAGENVEEYEAPKDRPNPVPNFINCQS-YLDMVKVAVFRYLFWFVLTVVFITGATRISVFGLGYLMSCFYLLLSGTTLLQKPMKAKLVLWDCLILYNITVILSKNMLSLLSCVFVQQMQTN-FCWVIQLFSLVC------TVKGYYNPQDMDKDRDCSLPVEEAGIIWDSICFLFLLLQRRVFLSCYFRHVVLDLRASSLQTSR 1095
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Match: chordc1 (cysteine and histidine rich domain containing 1 [Source:Xenbase;Acc:XB-GENE-962949]) HSP 1 Score: 465.692 bits (1197), Expect = 7.583e-133 Identity = 284/822 (34.55%), Postives = 447/822 (54.38%), Query Frame = 2
Query: 3545 DKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPV-PEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWR----DHSEFYKDIKISNEEEVNHIQPLKPQSAMRTGIK----------------------------FRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTES-----LKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLK-DHNQTYLNLTLSMKKENEA---------RWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWT 5863
D E ++ F +S+S+ LL++ +SE CYF++I+N+++S +L+SL P L+F WGMLS+ +PSK FW+ I +TE+++V KY+ QF N + + P P +LG+EKS +Y D+IQLL LF HRS L GLW D E ++ E+ Q L+P + ++ RN + +K F+ + + K DVYA MFL + +II+ G+++FG + + A + ++ P F+ M++ QF ++IDRAL+LRK V GK +FQ+ VI IH W+FF LP +T+R FN QL YF+KC+YFALS+YQ+R GYP RILGNFLT+ YN+ NL F+ + +PFL ELR VMDW+WTDT+++L +WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ F W PL S + + V N PI+ T + +GGY PLF +++ +++ ++ + ++ ++ + D+ I+GSS VW I+PPS E+++ +L++ S + Q + + T+EK + + + +LL+ + V I +FP+++ A + L+ D ++YL++ + + + A WW I + + + + L + IF+++VS G L + YGI+G+Y + + V + +R F+S+IS+ I EELP VDRIL L +IY+VRE LEE+L AKLIFLYRS ETMIKWT
Sbjct: 1400 DFPELSESQHFFQSQSRILRLLLALYNFVAAHSELLCYFIIILNNMVSASLISLFLPILIFLWGMLSIHKPSKRFWMTAIIFTEVMVVIKYLFQFGFFPWNNYTILVRNEGKPFFPPRVLGLEKSDSYIKYDLIQLLMLFFHRSLLMSYGLWDRKDLDLEERTPGKDKGSKTEIQASQDLEPAGGSSSSLRQRKRKESQGSVQERGAESNWTCAVQFTSLRNIYQPVKAFFHDILHTKNRAATDVYAFMFLADVVDFVIIVFGFWAFGKHSAAADIASS-LSDDQVPEAFLVMVLIQFSTMVIDRALYLRKTVLGKLIFQVILVIGIHVWMFFILPAVTERMFNQNTVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIIVFLICIIWFPLLFMSLVRSVVGVVNHPIDVTVTFKLGGYEPLFTMSAQQQSIQPFTPQQYEALTYEFERQPTAMQFITLYSYEDIVTARIEGSSGSVWGISPPSREQMRKELQNGSSDITLRFTWDFQRDLAKGGTVEHTSEKHTKDLEPGSQERMELADLLQGVRDTP----VSIQHLFPKYIRAPNGPEANPVKQLQPDEEESYLDVEVQLNRMRVAEGNSTSSFVEWWVI----------TLKDCEGEDCNILPMVIFNDKVSPPSLGFL-AGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIYVVRERGELELEEELYAKLIFLYRSPETMIKWT 2205 HSP 2 Score: 187.963 bits (476), Expect = 7.970e-47 Identity = 151/549 (27.50%), Postives = 265/549 (48.27%), Query Frame = 2
Query: 923 KLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQ---------YGNFANSSM--EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEV-------------EIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYP------LNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK--SDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGK---NADKQCSSVA--SGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSR 2458
K L Q +WRL E H K + + V+V + +V MN + +++ PF R + + ++ I++ KM+YQ+ + + +NC+Q NS++ E ID A W G+ K +I IL+ IV HQ + K +KP +F +V ++ S ++ L+ +S+ + ++F+ + C I + + + + LW Y +FL L QY+IC+G+PP LCI+YP + V L +WLYLP++ +P +++DFV I V Q++VF EK+++ + + + V++ + + +FI+ +S Y+D +K VF + +W L ++F TG I++FGLGYL+ F L G +L K+ + + ++ YN VIL+K + L+ CVF+ ++T CW++ LF++ C ++G + + D+ CS +G+ WD +CF F++LQR +F + F V LDL + +SR
Sbjct: 622 KFSELLHRLQVFLWRLLELHVLKLVALYSVWVALQEVSVMNFLFVVLWAFAMPFSRFQHMASCLCTIWTSIIIVCKMLYQLTVVNPLEYSSNCTQPLLNNTSLLEDEILNSTLYREPIDPANWFGIRKGYPNLGYIQNHLQILLLLVFEAIVYRHQEFYRKQYQLEKPHIQAVFPDVYREHLDQDSLVLNDVFISCNSYIHLMHFSI------LCFRMNFM-VIFHGCWLIVILTRRQRVNIAK-----------LWPKYCVFLIFFLLWQYMICLGIPPVLCIDYPWRWDTFVPVNSALIKWLYLPDFYTTPKSVNLISDFVLLIGVAQQWKVFINEKKEEWYTMAGENVEEYEAPKDRPNPVPNFINCQS-YLDMVKVAVFRYLFWFVLTVVFITGATRISVFGLGYLMSCFYLLLSGTTLLQKPMKAKLVLWDCLILYNITVILSKNMLSLLSCVFVQQMQTN-FCWVIQLFSLVC------TVKGYYNPQDMDKDRDCSLPVEEAGIIWDSICFLFLLLQRRVFLSCYFRHVVLDLRASSLQTSR 1144
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 397.127 bits (1019), Expect = 6.288e-111 Identity = 221/594 (37.21%), Postives = 349/594 (58.75%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQ---SSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKEN----EARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
PI+Q F+ + + + DVY +MFL + +II+ G+++FG + + + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KCVYF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ A KY +GG+++ W PL S I + V N P++ + +I++GGY P+F ++++ LK + +++ + + S +L ++E DVT ++G+S+ +WTI+PPS +K+ +L S + + +R+ ++ + L + ++ K I N S+ V I+ I+P ++ A + S+ L N ++N+T+ + ++N + WW + + +I Q L + +F+++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2171 PIRQ---FFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMTLGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMNITIILFRDNVTKSNSEWWVLN--------LTGSRIFNQGSQALELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2750 HSP 2 Score: 201.445 bits (511), Expect = 6.049e-51 Identity = 157/591 (26.57%), Postives = 292/591 (49.41%), Query Frame = 2
Query: 950 QPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEI------------IDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYK-LNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
Q +W + E H K + I++V + +V N + ++ P+ +L + V + I++ KM+YQ++ + N+ NCS N +++ + +D +W+GL K ++ L+ +++ + + Y ++Y+ N P + IF ++ + + KY +N+ F K GLE F+ +V V R+D Y++++ L+ L +R +W Y FL ++ QY +C+G+PP C +YP N+I +WLY P++ V P P ++ DF+ + LQ Q+F+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++R + ++ YN VI K I + C ++ L + CW++ F++ C ++G D +C S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K +++++R++ +I+ RQ ++ K + L SG+
Sbjct: 933 QVFMWWILELHIIKIVSSYIIWVTVKEVSLFNYVFLISWAFALPYAKLRRAASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCS-LPNENQTNIPLHELNKSLLYSAPVDPTEWVGLRKSSPLLVY-LRNNLLMLAILAFEVTVYRHQEYYRGRNNLTAPVSKTIFHDITRLHLDDGLINCAKYFVNYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIGVLYRRRRKAIAEVWPKYCCFLACIITFQYFVCIGIPPAPCRDYPWRFKGAYFNDNII----KWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRS-YLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGAL-VRNSCWLIQAFSLACT------VKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQESGE 1509 HSP 3 Score: 108.612 bits (270), Expect = 7.685e-23 Identity = 67/167 (40.12%), Postives = 97/167 (58.08%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNV-LPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEE 4048
+E + + F + +F L + + SE CYF++I+NH+ S ++++L P L+F W MLSVPRPS+ FW++ I YTE+ IV KY QF N L + + R P P I+G+EK Y + D+IQLL LF HRS LK +GLW + DI SN ++
Sbjct: 1893 DELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKER--PYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDE-----DDIVDSNTDK 2052
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 397.127 bits (1019), Expect = 7.395e-111 Identity = 221/594 (37.21%), Postives = 349/594 (58.75%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQ---SSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKEN----EARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
PI+Q F+ + + + DVY +MFL + +II+ G+++FG + + + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KCVYF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ A KY +GG+++ W PL S I + V N P++ + +I++GGY P+F ++++ LK + +++ + + S +L ++E DVT ++G+S+ +WTI+PPS +K+ +L S + + +R+ ++ + L + ++ K I N S+ V I+ I+P ++ A + S+ L N ++N+T+ + ++N + WW + + +I Q L + +F+++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2242 PIRQ---FFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMTLGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMNITIILFRDNVTKSNSEWWVLN--------LTGSRIFNQGSQALELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2821 HSP 2 Score: 201.06 bits (510), Expect = 7.312e-51 Identity = 157/591 (26.57%), Postives = 292/591 (49.41%), Query Frame = 2
Query: 950 QPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEI------------IDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYK-LNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
Q +W + E H K + I++V + +V N + ++ P+ +L + V + I++ KM+YQ++ + N+ NCS N +++ + +D +W+GL K ++ L+ +++ + + Y ++Y+ N P + IF ++ + + KY +N+ F K GLE F+ +V V R+D Y++++ L+ L +R +W Y FL ++ QY +C+G+PP C +YP N+I +WLY P++ V P P ++ DF+ + LQ Q+F+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++R + ++ YN VI K I + C ++ L + CW++ F++ C ++G D +C S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K +++++R++ +I+ RQ ++ K + L SG+
Sbjct: 948 QVFMWWILELHIIKIVSSYIIWVTVKEVSLFNYVFLISWAFALPYAKLRRAASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCS-LPNENQTNIPLHELNKSLLYSAPVDPTEWVGLRKSSPLLVY-LRNNLLMLAILAFEVTVYRHQEYYRGRNNLTAPVSKTIFHDITRLHLDDGLINCAKYFVNYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIGVLYRRRRKAIAEVWPKYCCFLACIITFQYFVCIGIPPAPCRDYPWRFKGAYFNDNII----KWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRS-YLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGAL-VRNSCWLIQAFSLACT------VKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQESGE 1524 HSP 3 Score: 108.612 bits (270), Expect = 7.990e-23 Identity = 67/167 (40.12%), Postives = 97/167 (58.08%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNV-LPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEE 4048
+E + + F + +F L + + SE CYF++I+NH+ S ++++L P L+F W MLSVPRPS+ FW++ I YTE+ IV KY QF N L + + R P P I+G+EK Y + D+IQLL LF HRS LK +GLW + DI SN ++
Sbjct: 1964 DELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKER--PYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDE-----DDIVDSNTDK 2123
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo2 (piezo-type mechanosensitive ion channel component 2 [Source:MGI Symbol;Acc:MGI:1918781]) HSP 1 Score: 397.127 bits (1019), Expect = 7.519e-111 Identity = 221/594 (37.21%), Postives = 349/594 (58.75%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQ---SSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKEN----EARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
PI+Q F+ + + + DVY +MFL + +II+ G+++FG + + + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KCVYF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ A KY +GG+++ W PL S I + V N P++ + +I++GGY P+F ++++ LK + +++ + + S +L ++E DVT ++G+S+ +WTI+PPS +K+ +L S + + +R+ ++ + L + ++ K I N S+ V I+ I+P ++ A + S+ L N ++N+T+ + ++N + WW + + +I Q L + +F+++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2196 PIRQ---FFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMTLGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMNITIILFRDNVTKSNSEWWVLN--------LTGSRIFNQGSQALELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2775 HSP 2 Score: 200.675 bits (509), Expect = 8.370e-51 Identity = 157/591 (26.57%), Postives = 292/591 (49.41%), Query Frame = 2
Query: 950 QPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEI------------IDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYK-LNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
Q +W + E H K + I++V + +V N + ++ P+ +L + V + I++ KM+YQ++ + N+ NCS N +++ + +D +W+GL K ++ L+ +++ + + Y ++Y+ N P + IF ++ + + KY +N+ F K GLE F+ +V V R+D Y++++ L+ L +R +W Y FL ++ QY +C+G+PP C +YP N+I +WLY P++ V P P ++ DF+ + LQ Q+F+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++R + ++ YN VI K I + C ++ L + CW++ F++ C ++G D +C S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K +++++R++ +I+ RQ ++ K + L SG+
Sbjct: 958 QVFMWWILELHIIKIVSSYIIWVTVKEVSLFNYVFLISWAFALPYAKLRRAASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCS-LPNENQTNIPLHELNKSLLYSAPVDPTEWVGLRKSSPLLVY-LRNNLLMLAILAFEVTVYRHQEYYRGRNNLTAPVSKTIFHDITRLHLDDGLINCAKYFVNYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIGVLYRRRRKAIAEVWPKYCCFLACIITFQYFVCIGIPPAPCRDYPWRFKGAYFNDNII----KWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRS-YLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGAL-VRNSCWLIQAFSLACT------VKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQESGE 1534 HSP 3 Score: 108.612 bits (270), Expect = 8.235e-23 Identity = 67/167 (40.12%), Postives = 97/167 (58.08%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNV-LPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEE 4048
+E + + F + +F L + + SE CYF++I+NH+ S ++++L P L+F W MLSVPRPS+ FW++ I YTE+ IV KY QF N L + + R P P I+G+EK Y + D+IQLL LF HRS LK +GLW + DI SN ++
Sbjct: 1918 DELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKER--PYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDE-----DDIVDSNTDK 2077
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:MGI Symbol;Acc:MGI:3603204]) HSP 1 Score: 350.517 bits (898), Expect = 1.570e-96 Identity = 219/608 (36.02%), Postives = 345/608 (56.74%), Query Frame = 2
Query: 4118 KQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKL-RSTESLKINMQAICERRSSDSKTTEKM-VRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLK-DHNQTYLNLTLSMKKENEA----------------RWW--EIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
+ L++F+ + + K DVYA+MFL + ++III G+++FG + + A + ++ P F+ M++ QF ++IDRAL+LRK V GK FQ+ V+ IH W+FF LP +T+R F+ QL YF+KC+YFALS+YQ+R GYP RILGNFLT+ YN+ NL F+ + +PFL ELR VMDW+WTDT+++L +WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ F W PL S I + V N PI+ T ++ +GGY PLF +++ ++ ++++ + + + ++ + D+ I+GSS +W I+PPS ++K +L T + + +R + T E +HT + ++ L + +E VV I +FP+++ A + L+ D + YL + + +++E WW E+Q+ K + L + IFS++VS G L + YGI+G+Y + + V + +R F+S+IS+ I EELP VDRIL L +I+LVRE + LEE+L AKLIFLYRS ETMIKWTR +
Sbjct: 1955 QPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFGKHSAATDIASS-LSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVV-IPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRREQVGTGASGEQAGTKASDFLEWWVIELQDC-------------KADCNLLPMVIFSDKVSPPSLGFL-AGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRERE 2546 HSP 2 Score: 210.305 bits (534), Expect = 1.189e-53 Identity = 182/640 (28.44%), Postives = 311/640 (48.59%), Query Frame = 2
Query: 893 VNNMVFTATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQ-YGNFAN-SSMEI---------IDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKP-KTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---NVIP---KLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHK--DFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQ-----RQAQHGKPELN-------------------------------EHYLVMRSGDYYLF 2641
V + + ++ T Q + RL E H K + + V+V + +V MN++L+++ P+PR + V + I++ KM+YQ+KI + +NC++ + N N +EI +D A W G+ K +I IL+ V+ V Y + + Y+ Q P + + ++ LKY +NF F K GLE+ F+ V V R++ +++ L+ L +R LW Y +FL + L QY++C+G+PP LCI+YP IP L +WLYLP++ +P +++DF+ + Q+QVF E+ ++ + LE + + +FI +S Y+D LK VF + +WL L ++F G I++FGLGYLL F L G +L ++ + + ++ YN VI++K + L+ CVF+ +++ CW++ LF++ C ++ + + ++ D +G+ WD +CFFF++LQR IF + FL V DL +SRG L N +KSI ++ EEK L +++R++K+I RQ+Q + +L +H V+ SGDY+LF
Sbjct: 778 VADRLLDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSLLYRGPVDPANWFGVRKGYPNLGYIQNHLQILL-LLVFEAVVYRRQEHYRRQHQQAPLPAQAVCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGINTDHLEPLRGEPNPIPNFIHCRS-YLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSN-FCWVIQLFSLVCTVKGYYDPKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQEPGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLF 1414 HSP 3 Score: 116.701 bits (291), Expect = 2.885e-25 Identity = 71/210 (33.81%), Postives = 108/210 (51.43%), Query Frame = 2
Query: 3497 KEIEKIVKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPV-PEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFY---------KDIKISNEEEVNHIQPLKPQSAMRTG 4096
+ +++ D R + E +E + F + + LL + + +SE CYF++I+NH+++ + SL P LVF W ML++PRPSK FW+ I +TE+++V KY+ QF N V + P P ILG+EK+ +Y D++QL+ LF HRS L GLW + Y KD + E E L+ QS TG
Sbjct: 1642 RTASELLLDRRLHIPELEEAER----FEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAK----LESQSETGTG 1843
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Match: Piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:MGI Symbol;Acc:MGI:3603204]) HSP 1 Score: 350.517 bits (898), Expect = 1.584e-96 Identity = 219/608 (36.02%), Postives = 345/608 (56.74%), Query Frame = 2
Query: 4118 KQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKL-RSTESLKINMQAICERRSSDSKTTEKM-VRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLK-DHNQTYLNLTLSMKKENEA----------------RWW--EIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
+ L++F+ + + K DVYA+MFL + ++III G+++FG + + A + ++ P F+ M++ QF ++IDRAL+LRK V GK FQ+ V+ IH W+FF LP +T+R F+ QL YF+KC+YFALS+YQ+R GYP RILGNFLT+ YN+ NL F+ + +PFL ELR VMDW+WTDT+++L +WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ F W PL S I + V N PI+ T ++ +GGY PLF +++ ++ ++++ + + + ++ + D+ I+GSS +W I+PPS ++K +L T + + +R + T E +HT + ++ L + +E VV I +FP+++ A + L+ D + YL + + +++E WW E+Q+ K + L + IFS++VS G L + YGI+G+Y + + V + +R F+S+IS+ I EELP VDRIL L +I+LVRE + LEE+L AKLIFLYRS ETMIKWTR +
Sbjct: 1956 QPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFGKHSAATDIASS-LSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVV-IPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRREQVGTGASGEQAGTKASDFLEWWVIELQDC-------------KADCNLLPMVIFSDKVSPPSLGFL-AGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRERE 2547 HSP 2 Score: 209.92 bits (533), Expect = 1.230e-53 Identity = 182/640 (28.44%), Postives = 311/640 (48.59%), Query Frame = 2
Query: 893 VNNMVFTATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQ-YGNFAN-SSMEI---------IDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKP-KTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---NVIP---KLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHK--DFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQ-----RQAQHGKPELN-------------------------------EHYLVMRSGDYYLF 2641
V + + ++ T Q + RL E H K + + V+V + +V MN++L+++ P+PR + V + I++ KM+YQ+KI + +NC++ + N N +EI +D A W G+ K +I IL+ V+ V Y + + Y+ Q P + + ++ LKY +NF F K GLE+ F+ V V R++ +++ L+ L +R LW Y +FL + L QY++C+G+PP LCI+YP IP L +WLYLP++ +P +++DF+ + Q+QVF E+ ++ + LE + + +FI +S Y+D LK VF + +WL L ++F G I++FGLGYLL F L G +L ++ + + ++ YN VI++K + L+ CVF+ +++ CW++ LF++ C ++ + + ++ D +G+ WD +CFFF++LQR IF + FL V DL +SRG L N +KSI ++ EEK L +++R++K+I RQ+Q + +L +H V+ SGDY+LF
Sbjct: 779 VADRLLDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEINQSLLYRGPVDPANWFGVRKGYPNLGYIQNHLQILL-LLVFEAVVYRRQEHYRRQHQQAPLPAQAVCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGINTDHLEPLRGEPNPIPNFIHCRS-YLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSN-FCWVIQLFSLVCTVKGYYDPKEMMTRDRDCLLPVEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSKDPQDPSQEPGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLF 1415 HSP 3 Score: 116.701 bits (291), Expect = 2.886e-25 Identity = 71/210 (33.81%), Postives = 108/210 (51.43%), Query Frame = 2
Query: 3497 KEIEKIVKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPV-PEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFY---------KDIKISNEEEVNHIQPLKPQSAMRTG 4096
+ +++ D R + E +E + F + + LL + + +SE CYF++I+NH+++ + SL P LVF W ML++PRPSK FW+ I +TE+++V KY+ QF N V + P P ILG+EK+ +Y D++QL+ LF HRS L GLW + Y KD + E E L+ QS TG
Sbjct: 1643 RTASELLLDRRLHIPELEEAER----FEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWDHEEDRYPKDHCRSSVKDREAKEEPEAK----LESQSETGTG 1844
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|M9MSG8|PIEZO_DROME (Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster OX=7227 GN=Piezo PE=2 SV=1) HSP 1 Score: 463.381 bits (1191), Expect = 6.059e-131 Identity = 282/825 (34.18%), Postives = 446/825 (54.06%), Query Frame = 2
Query: 3563 KQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW--------------------RDHSE--FYKDIKISNEEEVNHIQPLKPQSAMRTGIKF-RNPIKQLK---------KFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPG-TDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDEN-----------DKKNLLKAIEANQSS--------YVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEAR--WWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFS---NYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTR 5866
+++ +R +LIS + ++ CY ++ +N +++ +L+SLP P +VF WG LS+PRP+K FW+ LI YT+ +++ K I QF LI N +P PL I G+E YAI D+I LL LFLHR LK GLW RD S+ D + N++ + Q+++ +F + I QL+ KF+ + ++ DVYA+MFLC+F +++ G+ +FG T+S ++ NK P+PF+ M++ QF+ I+IDRAL+LRK + K +F F VI IH W+FF +P +T+R FNS PP + Y IKC Y LSSYQ++SGYP RILGNF T+ ++ N+I FK+YM IPFLYELR ++DW+ D+++ +F W+++ED+F I++++C R+SE ++P +R + SK +GG ++ IC WGPL L + N P + SI +G Y P+ Y + +++ + + + +M Y ++ ++A DV + + G+S +W I PP ++L LR+ +LK R++ +K ++ V + LDE+ + + ++ I +N ++ VV I + P+F+ + ++L + Y L + M ++NE WWEI++ Y NE + K ++SN T I +D F FS GIIG+Y ++ +A R +++F + I E+LP+VDR+L L +IYLVRE F LEE L AKL+FLYRS ET+IKWTR
Sbjct: 1702 EENFAQRDHHIIVEVLISSWYALLANTDLICYIVVFINQVVNASLISLPLPIMVFLWGTLSLPRPTKTFWVTLIAYTQAIVLIKCIFQFKLIWSNYHQLPNQ---PLTPAKIFGVENKAHYAIYDLILLLVLFLHRYLLKSQGLWKSGYKDTDNQFTKPTASIDERDDSDNLSQPDSRQLNDDAAQKLSLQVSQASLPGSPEFSKTGINQLERTKYTSSLYKFFFSLVHKS-RLATDVYALMFLCDFVNFFVLLFGFTAFGTQQTESDEGVQTYLAENKVPIPFLIMLLVQFLLIVIDRALYLRKALVNKIIFHFFSVIGIHIWMFFVVPAVTERTFNSLAPPIIFYVIKCFYMLLSSYQIKSGYPKRILGNFFTKGFSMVNMIAFKVYMQIPFLYELRTILDWVCIDSTMTIFDWLKMEDIFSNIYLIRCTRQSETDFPAMRAQKKASLSKLIMGGTIVLLIVICIWGPLCLFALGNAVGTSNVPFHVSLSIRIGPYDPI-YTTNNYDSIFEINPEMYSQMTNAYIKEKQALTFIAGYDATDVAAVRLAGNSPSLWNIAPPDRQRLLNDLRNNHTLKARFSYSLTRKAP-AKGLKENVGDEHAISLDESFEGRAALIHMLSETHDVEPIYSNGTTNGTTPEVEEVVVIPGMIPKFIKVLNSGDAAVVSVLSPKHYDYRPLVIKMHRDNETNGLWWEIRDYCNDTFY--NETLSKFAYSNCTSGIVMYTFNDKKFPSTFSFLTAGGIIGLYTTFVLLASRFMKSFIGGQNRKIMFEDLPYVDRVLQLCLDIYLVREALEFALEEDLFAKLLFLYRSPETLIKWTR 2518 HSP 2 Score: 203.371 bits (516), Expect = 8.537e-51 Identity = 193/670 (28.81%), Postives = 316/670 (47.16%), Query Frame = 2
Query: 806 AVQLQVTLRPTSIRVSGLLTFYLSEFIRDVNNMVFTATEKLKS----LYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVIL-KMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQ---LHILKWTAILVGCAVWH-IVRYHQMQF-YKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIP---KLRQWLYLPN-YKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSD------SHKLVKQRLLE----GFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCIN---------PMSWEIRGIHGKNADKQCSSVASG--LHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQA-------------QHGKP----------ELNEHYLVMRSGDYYLF 2641
A L+ + P++ G T +F V ++V + K+K+ ++ + WR E H K + I + +V ++II + V+G + V+++ L ++++L KMIYQI+ +L++ SQ+ N S +NA+W+GL K + + +L+ I + H ++ Q+Q K+ P T ++F + + ++ L+KY LNFGF K G+E+S I V R D+ ++VY L L++ L+L+R C +W + F I + QY++ VGLPP C+ +P + P +++W LP + VP K++ DF+ + + Q +F +E+R S+ S++ V + + F H DF S +Y D LK+ V YW TLA++F G L LGYL+ AFI+LW G + ++I +L +N IL K FQ+ GC+FM L TK CW+V + I C + P E+ G +C + L WD +CF FII Q IF + F + D N +SRGA +I K I + E++ L++I+RK+++I Q +HG P E+ H R+GDYY+F
Sbjct: 754 AGSLRKSQGPSAEAAPGATT----DFETSVRDLVRISFRKIKNKSEYIFKNFKDVFWRFLELHIMKAVYIAAFVCSVSEVCVLHIIFVGFCVLGATSRKAVQVVISRLISFIVTVIVLSKMIYQIE------YLSH-SQH-NVVCSDNRTANNAEWIGLTKADKVTGGLMSLLRTYIIYMVIVTMHAVISLRQLQMRVKIGALNAPPTKLLFPNIIRADAEKDLVGLVKYLLNFGFYKFGIEISLIALVSTITYRQDIVAVVYALWLVVLLLLRRSQCAKIWGVFQAFFAISILTQYIVLVGLPPSSCLVFPWDEGPFGEGIQRWAMLPGALHFNHVP-KLIFDFIVLVILNRQKSIFCIEQRYASNDDYPGGSNRSVIADIAQLGRVPFDNPTH-DFCSYIRNYSDILKNGVLCGFYWFTLAVVFLAGTNIADLLALGYLIGAFIFLWQGSDFYLRPIHTIIFRWKWLLAFNVANILIKTSFQMAGCLFMTQL-TKDCCWLVHMLGITCTSNVLTEQIMLPEEAELALKPG-----ECPKITHQVVLLWDTICFAFIIFQLRIFKSHYFCHIITDTKANNILASRGADIIESLRHKQIAHRHDHEKQVLHKIKRKMERIRATQQKMLRPLDKQTHFDEHGYPLPAPTVRRRKEIKLHPHATRAGDYYMF 1403
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q9H5I5|PIEZ2_HUMAN (Piezo-type mechanosensitive ion channel component 2 OS=Homo sapiens OX=9606 GN=PIEZO2 PE=1 SV=2) HSP 1 Score: 403.29 bits (1035), Expect = 5.800e-112 Identity = 221/593 (37.27%), Postives = 351/593 (59.19%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEAN---QSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARW---WEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
PIKQ F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KCVYF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S I + V N P++ + +I++GGY P+F ++++ LK + + +F+K + + + +L ++E D+T ++G+S+ +WTI+PPS +K+ +L S + + +R+ ++ + L +KN+ K I N S V I+ I+P ++ A + S+ L N ++++T+ + ++N ++ W + + Y N + L + +F+++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2170 PIKQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMDITIILSRDNTTKYNSEWWVLNLTGNRIYNPNSQ-------ALELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2749 HSP 2 Score: 200.675 bits (509), Expect = 5.927e-50 Identity = 159/587 (27.09%), Postives = 290/587 (49.40%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYG--------NFANSSM---EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYK-LNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
+W + E H K + I++V + +V N + ++ P+ +L + + V + I++ KM+YQ++ + N+ NCS N N S+ ID +W+GL K ++ L+ +++ + + Y ++Y+ N P + IF ++ + + KY +N+ F K GLE F+ +V V R+D Y++++ L+ L +R +W Y FL ++ QY IC+G+PP C +YP N+I +WLY P++ V P P ++ DF+ + LQ Q+F+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++R + ++ YN VI K I + C ++ L CW++ F++ C ++G A+ C+ S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K +++++R++ +I+ RQ ++ K + L G+
Sbjct: 934 MWWILELHIIKIVSSYIIWVSVKEVSLFNYVFLISWAFALPYAKLRRLASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPFNELNKSLLYSAPIDPTEWVGLRKSSPLLVY-LRNNLLMLAILAFEVTIYRHQEYYRGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYFINYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITFQYFICIGIPPAPCRDYPWRFKGASFNDNII----KWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRS-YLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTL-VHNSCWLIQAFSLACT------VKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGE 1507 HSP 3 Score: 127.102 bits (318), Expect = 1.322e-27 Identity = 74/213 (34.74%), Postives = 113/213 (53.05%), Query Frame = 2
Query: 3527 RKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW-------------------------RDHSEFYKDIKISNEEEVNHIQPLKPQSAMR 4090
+K +D+ E++++ F + +F L + + SE CYF++I+NH++S ++++L P L+F W MLSVPRPS+ FW++ I YTE+ IV KY QF N V ++ P P I+G+EK Y + D+IQLL LF HRS LK +GLW RD S+ K I ++ E H+ + Q+A+R
Sbjct: 1886 KKMFHDDELEESEK--FYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNK-NVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKSINLAASVESVHVTFPEQQTAVR 2095
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q8CD54|PIEZ2_MOUSE (Piezo-type mechanosensitive ion channel component 2 OS=Mus musculus OX=10090 GN=Piezo2 PE=1 SV=2) HSP 1 Score: 396.741 bits (1018), Expect = 6.138e-110 Identity = 221/594 (37.21%), Postives = 349/594 (58.75%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQ---SSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKEN----EARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
PI+Q F+ + + + DVY +MFL + +II+ G+++FG + + + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+RKF+ QL YF+KCVYF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IF+LKCWR SE YP RG ++ A KY +GG+++ W PL S I + V N P++ + +I++GGY P+F ++++ LK + +++ + + S +L ++E DVT ++G+S+ +WTI+PPS +K+ +L S + + +R+ ++ + L + ++ K I N S+ V I+ I+P ++ A + S+ L N ++N+T+ + ++N + WW + + +I Q L + +F+++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2240 PIRQ---FFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMTLGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENN-FMNITIILFRDNVTKSNSEWWVLN--------LTGSRIFNQGSQALELVVFNDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTRE 2819 HSP 2 Score: 201.06 bits (510), Expect = 5.288e-50 Identity = 157/591 (26.57%), Postives = 292/591 (49.41%), Query Frame = 2
Query: 950 QPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEI------------IDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYK-LNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
Q +W + E H K + I++V + +V N + ++ P+ +L + V + I++ KM+YQ++ + N+ NCS N +++ + +D +W+GL K ++ L+ +++ + + Y ++Y+ N P + IF ++ + + KY +N+ F K GLE F+ +V V R+D Y++++ L+ L +R +W Y FL ++ QY +C+G+PP C +YP N+I +WLY P++ V P P ++ DF+ + LQ Q+F+ E + D+ ++ F Q + DFI +S Y+D K ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++R + ++ YN VI K I + C ++ L + CW++ F++ C ++G D +C S +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K +++++R++ +I+ RQ ++ K + L SG+
Sbjct: 948 QVFMWWILELHIIKIVSSYIIWVTVKEVSLFNYVFLISWAFALPYAKLRRAASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCS-LPNENQTNIPLHELNKSLLYSAPVDPTEWVGLRKSSPLLVY-LRNNLLMLAILAFEVTVYRHQEYYRGRNNLTAPVSKTIFHDITRLHLDDGLINCAKYFVNYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIGVLYRRRRKAIAEVWPKYCCFLACIITFQYFVCIGIPPAPCRDYPWRFKGAYFNDNII----KWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRS-YLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGAL-VRNSCWLIQAFSLACT------VKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQESGE 1524 HSP 3 Score: 108.612 bits (270), Expect = 5.683e-22 Identity = 67/167 (40.12%), Postives = 97/167 (58.08%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNV-LPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEE 4048
+E + + F + +F L + + SE CYF++I+NH+ S ++++L P L+F W MLSVPRPS+ FW++ I YTE+ IV KY QF N L + + R P P I+G+EK Y + D+IQLL LF HRS LK +GLW + DI SN ++
Sbjct: 1962 DELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKER--PYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDE-----DDIVDSNTDK 2121
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q0KL00|PIEZ1_RAT (Piezo-type mechanosensitive ion channel component 1 OS=Rattus norvegicus OX=10116 GN=Piezo1 PE=1 SV=3) HSP 1 Score: 360.533 bits (924), Expect = 9.555e-99 Identity = 223/604 (36.92%), Postives = 348/604 (57.62%), Query Frame = 2
Query: 4118 KQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRS-----TESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLK-DHNQTYLNLTLSMKKENEARWWEIQEIVAGE---TYCSN-------EKIPKQSHSN-LTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
+ L++F+ + + K DVYA+MFL + +++II G+++FG + + A + ++ P F+ M++ QF ++IDRAL+LRK V G FQ+ V+ IH W+FF LP +T+R F QL YF+KC+YFALS+YQ+R GYP RILGNFLT+ YN+ NL F+ + +PFL ELR VMDW+WTDT+++L +WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ F W PL S I + V N PI+ T ++ +GGY PLF +++ ++ + ++++ + + + ++ + D+ I+GSS +W I+PPS ++K +L + T N Q + S T EK HT + ++ L + +E VV I +FP+++ A + L+ D + YL + + +++E ++ +GE T S+ E Q+ N L + IFS++VS G L + YGI+G+Y + + V + +R F+SDIS+ I EELP VDRIL L +I+LVRE + LEE+L AKLIFLYRS ETMIKWTR +
Sbjct: 1944 QPLRRFFHDILHTKYRAATDVYALMFLADIVDIVVIIFGFWAFGKHSAATDIASS-LSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGNLAFQVVLVVAIHLWMFFILPAVTERMFRQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPEDYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKHELYNGTADITLRFTWNFQRDLAKGGSVEYTNEK---HTLELAPNSTARRQLAQLLEGRPDQSVV-IPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRRE------QVGTGTSGEQAGTKASDFLEWWVIELQDCQAECNLLPMVIFSDKVSPPSLGFL-AGYGIVGLYVSIVLVVGKFVRGFFSDISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTREKE 2535 HSP 2 Score: 210.305 bits (534), Expect = 7.435e-53 Identity = 177/611 (28.97%), Postives = 304/611 (49.75%), Query Frame = 2
Query: 968 LWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQ-YGNFAN-SSMEI---------IDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKP-KTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---NVIP---KLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHK--DFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQ-----RQAQHGKPELN---------------------------EHYLVMRSGDYYLF 2641
L E H K + + V+V + +V MN++L+++ P+PR + V + I++ KM+YQ+KI + +NC++ + N N +EI +D A W G+ K +I IL+ V+ V Y + + Y+ Q P + + ++ LKY +NF F K GLE+ F+ V V R++ +++ L+ L +R LW Y +FL + L QY++C+G+PP LCI+YP IP L +WLYLP++ +P +++DF+ + Q+QVF E+ ++ V LE + + +FI +S Y+D LK VF + +WL L ++F TG I++FGLGYLL F L G +L ++ + + ++ YN VI++K + L+ CVF+ +++ CW++ LF++ C ++ + + ++ D +G+ WD +CFFF++LQR +F + FL V DL +SRG L N +K+I +++EE+ L +++R++K+I RQ+Q + +L +H V+ SGDY+LF
Sbjct: 795 LLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEISQSLLYRGPVDPANWFGVRKGYPNLGYIQNHLQILL-LLVFEAVVYRRQEHYRRQHQQAPLPAQALCADGTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSQAIPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAEQTEEWQRMAGVNTDHLEPLRGEPNPIPNFIHCRS-YLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSN-FCWVIQLFSLVCTVKGYYDPKEMKTRDRDCLLPVEEAGIIWDSICFFFLLLQRRVFLSHYFLHVSADLKATALQASRGFALYNAANIKNINFHRQTEERSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSTDPQEPGPDSPGGSSPPRTQWWRPWQDHATVIHSGDYFLF 1402 HSP 3 Score: 118.627 bits (296), Expect = 5.161e-25 Identity = 72/255 (28.24%), Postives = 128/255 (50.20%), Query Frame = 2
Query: 3497 KEIEKIVKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLN-VLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW--------RDH---------SEFYKDIKISNEEEVNHIQPLKP------------QSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKR 4171
+ +++ D R + E +E + F + + LL + + +SE CYF++I+NH+++ + SL P LVF W ML++PRPSK FW+ I +TE+++V KY+ QF N + + + P P ILG+EK+ +Y D++QL+ LF HRS L GLW +DH +E + K+ ++ E P +P + ++R+ + ++P + LK + + + + +R
Sbjct: 1630 RTASELLLDRRLRIPELEEAEQ----FEAQQGRTLRLLRAMYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYIVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWDHEEDGVPKDHCRSSEKDQEAEEESEAKLESQPETGTGHPEEPVLTGTPKDHIQGKGSVRSKDEIQDPPEDLKPQHRRHISIRFRRR 1880
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Match: sp|Q92508|PIEZ1_HUMAN (Piezo-type mechanosensitive ion channel component 1 OS=Homo sapiens OX=9606 GN=PIEZO1 PE=1 SV=4) HSP 1 Score: 357.836 bits (917), Expect = 6.101e-98 Identity = 217/596 (36.41%), Postives = 339/596 (56.88%), Query Frame = 2
Query: 4118 KQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKL-RSTESLKINMQAICERRSSDSKTTEKM-VRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQT-YLNLTLSMKKENEA------RWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
+ L++F+ + + K DVYA+MFL + +III G+++FG + + + ++ P F+ M++ QF +++DRAL+LRK V GK FQ+ V+ IH W+FF LP +T+R FN QL YF+KC+YFALS+YQ+R GYP RILGNFLT+ YN+ NL F+ + +PFL ELR VMDW+WTDT+++L WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ F W PL S + + V N PI+ T ++ +GGY PLF +++ ++ ++++ + ++ + D+ I+GSS +W I+PPS ++K +L T + + +R + T E +H + ++ L +E VV I +FP+++ A + L+ + + YL + + +++E A WW I E+ T C + L + IFS++VS G L + YGI+G+Y + + V + +R F+S+IS+ I EELP VDRIL L +I+LVRE + LEE+L AKLIFLYRS ETMIKWTR +
Sbjct: 1940 RPLRRFFHDILHTKYRAATDVYALMFLADVVDFIIIIFGFWAFGKHS-AATDITSSLSDDQVPEAFLVMLLIQFSTMVVDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSSWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQSVV-IPNLFPKYIRAPNGPEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVI-ELQECRTDC----------NLLPMVIFSDKVSPPSLGFL-AGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTREKE 2521 HSP 2 Score: 215.312 bits (547), Expect = 2.072e-54 Identity = 169/566 (29.86%), Postives = 293/566 (51.77%), Query Frame = 2
Query: 965 RLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSS----MEI---------IDNAKWLGLEK----LENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKP-KTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRID-VYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLN---VIP---KLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHK--DFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQH 2581
RL E H K + + V+V + +V MN++L+++ P+PR + V + I++ KM+YQ+K+ + +NC++ F NS+ EI +D A W G+ K L Q H+ +L+ V+ + Y + + Y+ P +F ++ LKY +NF F K GLE+ F+ V V R++ + +L ++ + R LW Y +FL + L QY++C+G+PP LCI+YP +P L +WLYLP++ +P +++DF+ + Q+QVF E+ ++ V LE + + +FI +S Y+D LK VF + +WL L ++F TG I++FGLGYLL F L G +L ++ + + ++ YN VI++K + L+ CVF+ ++T G CW++ LF++ C ++ + + ++ D +G+ WD VCFFF++LQR +F + +L V+ DL +SRG L N +KSI+ ++ EEK L +++R++++I +Q +H
Sbjct: 808 RLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCVIIVCKMLYQLKVVNPQEYSSNCTE--PFPNSTNLLPTEISQSLLYRGPVDPANWFGVRKGFPNLGYIQNHL---QVLLL--LVFEAIVYRRQEHYRRQHQLAPLPAQAVFASGTRQQLDQDLLGCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFLVTLHGCWLVAILTRRHRQAIARLWPNYCLFLALFLLYQYLLCLGMPPALCIDYPWRWSRAVPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGVNTDRLEPLRGEPNPVPNFIHCRS-YLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTALLQRDTRARLVLWDCLILYNVTVIISKNMLSLLACVFVEQMQT-GFCWVIQLFSLVCTVKGYYDPKEMMDRDQDCLLPVEEAGIIWDSVCFFFLLLQRRVFLSHYYLHVRADLQATALLASRGFALYNAANLKSIDFHRRIEEKSLAQLKRQMERIRAKQEKH 1364 HSP 3 Score: 113.235 bits (282), Expect = 2.347e-23 Identity = 59/144 (40.97%), Postives = 85/144 (59.03%), Query Frame = 2
Query: 3584 SRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNV-LPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSE 4012
+ + LL + + +SE CYF++I+NH+++ + SL P LVF W MLS+PRPSK FW+ I +TE+ +V KY+ QF N + + + P P ILG+EK+ Y D++QL+ LF HRS L GLW DH E
Sbjct: 1668 GQGRALRLLRAVYQCVAAHSELLCYFIIILNHMVTASAGSLVLPVLVFLWAMLSIPRPSKRFWMTAIVFTEIAVVVKYLFQFGFFPWNSHVVLRRYENKPYFPPRILGLEKTDGYIKYDLVQLMALFFHRSQLLCYGLW-DHEE 1810
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A0L8GDG7 (Piezo-type mechanosensitive ion channel component OS=Octopus bimaculoides OX=37653 GN=OCBIM_22035390mg PE=3 SV=1) HSP 1 Score: 853.203 bits (2203), Expect = 0.000e+0 Identity = 581/1752 (33.16%), Postives = 890/1752 (50.80%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSM-----EIIDNAKWLGLEKLENFQL--HILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVI--PKLRQWLYLPNYKVSPVPGKIL-ADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQR-LLEGFQKSIH---KDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKP--ELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXXXXXXXXXLRVNLDMLPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSN--GNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEE----EKKLVKSHVLS-----------TFIEIDEKLGKEIEKI-------------VKDGRKSVS----EDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEH-RIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIK----------------------------------------ISNEEEVN------------------HIQPLKPQSAMRT--GIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTL-SEATALLKDHNQTYLNLTLS----MKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTR 5866
+WRL E H K + I+ V +V A++ + ++I+ + + +++ L + +A +++ K +Q+ + + +W NC+ + + M E I+N W+GLEK+++ L +++ + AIL+ A IVRYHQ Q YK + ++PK +IF V + + D+LKY N+ F K GLE+ +I T + +R+D YS++Y + L L++ R +W Y++ L +LLP+QY+ +G GLC EYP + P L+ WL+LP+Y + P P IL ADF Q +FV LQ+QVF +E+ +S ++ + +L + S+ DF + +SY+D K+ VFY +W+T+AI+F G I +FGLGY++I F ++W G+ L+ + L+ N ++ Y F+V+L K QL+GCV+M+ + CW V LF I C+N E G C + +GL WDV+CF F++LQR ++++ F + +L Q + +SRGA LIN +++ + QK+ E + L I++K++ ++ +QA K E +EH+ +RSGDYYLF ED++ + ++ S+ I E+SG +D L PLQL++ + G A+ E+ RE + + + HD++ PS ++ + AIV GT SVD V + + ES N L + + S L FN +R Y R L + EK +++ L+ T ++ E + + E I D RKS + +D + +++ F ++ F+ LL+++ + I SE CYFL+++N ++S +LLS+P P +VF WGMLSVPRPSK FW+ +ITYTE ++V KY+ QF N ++ + +P P ILGIEK YA+ D+ LL LF+HR+ LK GLW+D + D+ E EV+ HI L+P+ A T KF + +K + FY +MTN N VDVYA MF+C+F A LI++ GY++FGP G +++ N+ P+PF+ M++ QF+FIIIDRALFLRK V GKF+FQ+ VI++H WLFF LP IT R F P L YF+KC+YFALS++Q+RSGYP RILGNFLT+NY+Y NL FK ++ IPFL ELR +MDWMWTDT++AL W+++ED++ IFVLKCWR +E YPT R R+ KY VGGLLL W PL L SF T + NPP CT IS+GGY PLF ++ ++ +L + + + + Y + +L S++ D+T I+I+G S VW I+PPS +KL L + + +++ R ++ + ++ K L + I SS +V I +F F+ + S L+K+ + + L K WW + E + N K + S L + F++R++ F L + YGIIG+Y + +FV R R F S++S+ I ELP VD IL L +IYLVRE LEE+L AKLIFLYRS ETMI+WT+
Sbjct: 468 LWRLTEIHIYKVVGFTIMVVAAKEVSAISAVYVIILALFLLLVKCRLLLSHILQIYTALVLLAKTSFQMSVARVTDWENNCTDTWSNSTDEMDYPFNETINNNIWIGLEKVDSNYLPNYLVNYVAILLIIAFQSIVRYHQHQHYKHSEHRRPKEGIIFCNVTREDADKGIIDVLKYFANYFFYKFGLEICYITTAITISVRVDAYSILYAIFLAALLLMNRRNNARVWPVYVLILTVLLPLQYMSSLGFLLGLCTEYPWKEMLKPSLQYWLFLPSY-LHPPPAIILIADFFQLLFVCLQWQVFNVEQGSQSTNYAGGDNKDILPEVEASLEIPVPDFTTTMASYLDVAKYAVFYHLFWVTMAIVFFAGTNRINIFGLGYVIIVFCFMWFGREFLLKPLRKLLWWWNFLIGYTFIVLLVKISLQLVGCVYMDGVGIAH-CWAVKLFGITCLNSFPKEQHG--------NCEADKNGLGWDVICFAFLLLQRRVYSSHYFRHIVAELEAQRRLASRGAELINRILIREVLLQKERETEVLYTIKKKMEHLKAKQAGLKKSFHEPDEHFQAIRSGDYYLF--------------------------------------------------EDETEEVPESPDQGPTTSLNI------GRSERSGSED----KALGPLQLLSTAIDSGTDTAL----------------------------------------EKAREETDQPVSQHDST---------------PSGDK-------HVAIV-MGT--SVDKVEDEETTKPKESLCSKISNSFSLFIAILVSMANWLIKFFNRISRNYRRVAYTLTDDMRKEKLKIQAEKLTFLSLSAMEEGITTVDSKEAVTRAAEDIGVNKIAVEVDTPQETDIRKSFTKTNLQDIDNAEEENEFELAQPVFYRLLVAYYYMLISRSELVCYFLIVLNQMMSASLLSMPLPIMVFLWGMLSVPRPSKTFWVTVITYTEAIVVLKYLFQFTFFPWNDDDNSKNWKNNPFWPPRILGIEKQDYYAMYDLALLLVLFIHRTILKRYGLWKDAEDITADLAKAEGKELSPPASPQMHDERKFAAAAATAAAVPEKQEYDFDAGQESEVDVPLKKKMIVTQDPKDNSPHITTLEPEPAEETVQKKKFVSVMKPFQNFYRQMTNSAYNAVVDVYAPMFVCDFLAFLIVVFGYWAFGPVQSGEGSVTTYLEENRVPIPFLVMLVVQFMFIIIDRALFLRKCVHGKFIFQVSLVIIVHIWLFFILPAITNRMFIKNVPAMLWYFVKCIYFALSAHQIRSGYPTRILGNFLTKNYSYLNLFLFKGFLVIPFLLELRALMDWMWTDTTLALGSWLQMEDIYANIFVLKCWRHAEATYPTPRALKRKSTIKYGVGGLLLLLIIFIIWFPLVLFSFANTVYEVNPPKTCTVRISLGGYQPLFKMTVQQADIFALDESQYKLLHKFYDTTPRASSFLTSYDPQDITVITINGESTSVWGISPPSQKKLIRDLMDAKHMDMDLDVSFTRGKRSPQSPGTFSKQFQVTLTNDTASK-LAQIISGGNSSQLVAIPKLFYPFMRLQNNGIVSVVHPLMKEKEEPDIYLGFRSGNISKSSGRVDWWYVSEETDLNIWKPNS---KSNASRLILVTFNDRIAPATFS-LITGYGIIGLYVSMVFVIGRFARMFVSEVSFRIMFMELPRVDNILKLCLDIYLVRECSDLCLEEELFAKLIFLYRSPETMIRWTK 2079
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A0L8GD91 (Piezo-type mechanosensitive ion channel component OS=Octopus bimaculoides OX=37653 GN=OCBIM_22035390mg PE=3 SV=1) HSP 1 Score: 850.892 bits (2197), Expect = 0.000e+0 Identity = 586/1763 (33.24%), Postives = 893/1763 (50.65%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSM-----EIIDNAKWLGLEKLENFQL--HILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVI--PKLRQWLYLPNYKVSPVPGKIL-ADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQR-LLEGFQKSIH---KDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKP--ELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXXXXXXXXXLRVNLDMLPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSN--GNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEE----EKKLVKSHVLS-----------TFIEIDEKLGKEIEKI-------------VKDGRKSVS----EDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEH-RIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIK----------------------------------------ISNEEEVN------------------HIQPLKPQSAMRT----------GIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICER--RSSDSKTT-EKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTL-SEATALLKDHNQTYLNLTLS----MKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTR 5866
+WRL E H K + I+ V +V A++ + ++I+ + + +++ L + +A +++ K +Q+ + + +W NC+ + + M E I+N W+GLEK+++ L +++ + AIL+ A IVRYHQ Q YK + ++PK +IF V + + D+LKY N+ F K GLE+ +I T + +R+D YS++Y + L L++ R +W Y++ L +LLP+QY+ +G GLC EYP + P L+ WL+LP+Y + P P IL ADF Q +FV LQ+QVF +E+ +S ++ + +L + S+ DF + +SY+D K+ VFY +W+T+AI+F G I +FGLGY++I F ++W G+ L+ + L+ N ++ Y F+V+L K QL+GCV+M+ + CW V LF I C+N E G C + +GL WDV+CF F++LQR ++++ F + +L Q + +SRGA LIN +++ + QK+ E + L I++K++ ++ +QA K E +EH+ +RSGDYYLF ED++ + ++ S+ I E+SG +D L PLQL++ + G A+ E+ RE + + + HD++ PS ++ + AIV GT SVD V + + ES N L + + S L FN +R Y R L + EK +++ L+ T ++ E + + E I D RKS + +D + +++ F ++ F+ LL+++ + I SE CYFL+++N ++S +LLS+P P +VF WGMLSVPRPSK FW+ +ITYTE ++V KY+ QF N ++ + +P P ILGIEK YA+ D+ LL LF+HR+ LK GLW+D + D+ E EV+ HI L+P+ A T +F + +K + FY +MTN N VDVYA MF+C+F A LI++ GY++FGP G +++ N+ P+PF+ M++ QF+FIIIDRALFLRK V GKF+FQ+ VI++H WLFF LP IT R F P L YF+KC+YFALS++Q+RSGYP RILGNFLT+NY+Y NL FK ++ IPFL ELR +MDWMWTDT++AL W+++ED++ IFVLKCWR +E YPT R R+ KY VGGLLL W PL L SF T + NPP CT IS+GGY PLF ++ ++ +L + + + + Y + +L S++ D+T I+I+G S VW I+PPS +KL L + + +++ R RS S T K + T L + L + I SS +V I +F F+ + S L+K+ + + L K WW + E + N K + S L + F++R++ F L + YGIIG+Y + +FV R R F S++S+ I ELP VD IL L +IYLVRE LEE+L AKLIFLYRS ETMI+WT+
Sbjct: 465 LWRLTEIHIYKVVGFTIMVVAAKEVSAISAVYVIILALFLLLVKCRLLLSHILQIYTALVLLAKTSFQMSVARVTDWENNCTDTWSNSTDEMDYPFNETINNNIWIGLEKVDSNYLPNYLVNYVAILLIIAFQSIVRYHQHQHYKHSEHRRPKEGIIFCNVTREDADKGIIDVLKYFANYFFYKFGLEICYITTAITISVRVDAYSILYAIFLAALLLMNRRNNARVWPVYVLILTVLLPLQYMSSLGFLLGLCTEYPWKEMLKPSLQYWLFLPSY-LHPPPAIILIADFFQLLFVCLQWQVFNVEQGSQSTNYAGGDNKDILPEVEASLEIPVPDFTTTMASYLDVAKYAVFYHLFWVTMAIVFFAGTNRINIFGLGYVIIVFCFMWFGREFLLKPLRKLLWWWNFLIGYTFIVLLVKISLQLVGCVYMDGVGIAH-CWAVKLFGITCLNSFPKEQHG--------NCEADKNGLGWDVICFAFLLLQRRVYSSHYFRHIVAELEAQRRLASRGAELINRILIREVLLQKERETEVLYTIKKKMEHLKAKQAGLKKSFHEPDEHFQAIRSGDYYLF--------------------------------------------------EDETEEVPESPDQGPTTSLNI------GRSERSGSED----KALGPLQLLSTAIDSGTDTAL----------------------------------------EKAREETDQPVSQHDST---------------PSGDK-------HVAIV-MGT--SVDKVEDEETTKPKESLCSKISNSFSLFIAILVSMANWLIKFFNRISRNYRRVAYTLTDDMRKEKLKIQAEKLTFLSLSAMEEGITTVDSKEAVTRAAEDIGVNKIAVEVDTPQETDIRKSFTKTNLQDIDNAEEENEFELAQPVFYRLLVAYYYMLISRSELVCYFLIVLNQMMSASLLSMPLPIMVFLWGMLSVPRPSKTFWVTVITYTEAIVVLKYLFQFTFFPWNDDDNSKNWKNNPFWPPRILGIEKQDYYAMYDLALLLVLFIHRTILKRYGLWKDAEDITADLAKAEGKELSPPASPQMHDERKFAAAAATAAAVPEKQEYDFDAGQESEVDVPLKKKMIVTQDPKDNSPHITTLEPEPAEETVQKKNILTVLETRFVSVMKPFQNFYRQMTNSAYNAVVDVYAPMFVCDFLAFLIVVFGYWAFGPVQSGEGSVTTYLEENRVPIPFLVMLVVQFMFIIIDRALFLRKCVHGKFIFQVSLVIIVHIWLFFILPAITNRMFIKNVPAMLWYFVKCIYFALSAHQIRSGYPTRILGNFLTKNYSYLNLFLFKGFLVIPFLLELRALMDWMWTDTTLALGSWLQMEDIYANIFVLKCWRHAEATYPTPRALKRKSTIKYGVGGLLLLLIIFIIWFPLVLFSFANTVYEVNPPKTCTVRISLGGYQPLFKMTVQQADIFALDESQYKLLHKFYDTTPRASSFLTSYDPQDITVITINGESTSVWGISPPSQKKLIRDLMDAKHMDMDLDVSFTRGKRSPQSPGTFSKQFQVT----LTNDTASKLAQIISGGNSSQLVAIPKLFYPFMRLQNNGIVSVVHPLMKEKEEPDIYLGFRSGNISKSSGRVDWWYVSEETDLNIWKPNS---KSNASRLILVTFNDRIAPATFS-LITGYGIIGLYVSMVFVIGRFARMFVSEVSFRIMFMELPRVDNILKLCLDIYLVRECSDLCLEEELFAKLIFLYRSPETMIRWTK 2084
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A0L8GD81 (Piezo-type mechanosensitive ion channel component OS=Octopus bimaculoides OX=37653 GN=OCBIM_22035390mg PE=3 SV=1) HSP 1 Score: 850.507 bits (2196), Expect = 0.000e+0 Identity = 587/1756 (33.43%), Postives = 891/1756 (50.74%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSM-----EIIDNAKWLGLEKLENFQL--HILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVI--PKLRQWLYLPNYKVSPVPGKIL-ADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQR-LLEGFQKSIH---KDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKP--ELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXXXXXXXXXLRVNLDMLPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSN--GNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEE----EKKLVKSHVLS-----------TFIEIDEKLGKEIEKI-------------VKDGRKSVS----EDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEH-RIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIK----------------------------------------ISNEEEVN------------------HIQPLKPQSAMRT--GIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICER--RSSDSKTT-EKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTL-SEATALLKDHNQTYLNLTLS----MKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
+WRL E H K + I+ V +V A++ + ++I+ + + +++ L + +A +++ K +Q+ + + +W NC+ + + M E I+N W+GLEK+++ L +++ + AIL+ A IVRYHQ Q YK + ++PK +IF V + + D+LKY N+ F K GLE+ +I T + +R+D YS++Y + L L++ R +W Y++ L +LLP+QY+ +G GLC EYP + P L+ WL+LP+Y + P P IL ADF Q +FV LQ+QVF +E+ +S ++ + +L + S+ DF + +SY+D K+ VFY +W+T+AI+F G I +FGLGY++I F ++W G+ L+ + L+ N ++ Y F+V+L K QL+GCV+M+ + CW V LF I C+N E G C + +GL WDV+CF F++LQR ++++ F + +L Q + +SRGA LIN +++ + QK+ E + L I++K++ ++ +QA K E +EH+ +RSGDYYLF ED++ + ++ S+ I E+SG +D L PLQL++ + G A+ E+ RE + + + HD++ PS ++ + AIV GT SVD V + + ES N L + + S L FN +R Y R L + EK +++ L+ T ++ E + + E I D RKS + +D + +++ F ++ F+ LL+++ + I SE CYFL+++N ++S +LLS+P P +VF WGMLSVPRPSK FW+ +ITYTE ++V KY+ QF N ++ + +P P ILGIEK YA+ D+ LL LF+HR+ LK GLW+D + D+ E EV+ HI L+P+ A T KF + +K + FY +MTN N VDVYA MF+C+F A LI++ GY++FGP G +++ N+ P+PF+ M++ QF+FIIIDRALFLRK V GKF+FQ+ VI++H WLFF LP IT R F P L YF+KC+YFALS++Q+RSGYP RILGNFLT+NY+Y NL FK ++ IPFL ELR +MDWMWTDT++AL W+++ED++ IFVLKCWR +E YPT R R+ KY VGGLLL W PL L SF T + NPP CT IS+GGY PLF ++ ++ +L + + + + Y + +L S++ D+T I+I+G S VW I+PPS +KL L + + +++ R RS S T K + T L + L + I SS +V I +F F+ + S L+K+ + + L K WW + E + N K + S L + F++R++ F L + YGI G+Y ++I + R LR ++ I ELP VDRIL L +IYLVRE FRLEE L AKLIFLYRS ET+IKWTR
Sbjct: 468 LWRLTEIHIYKVVGFTIMVVAAKEVSAISAVYVIILALFLLLVKCRLLLSHILQIYTALVLLAKTSFQMSVARVTDWENNCTDTWSNSTDEMDYPFNETINNNIWIGLEKVDSNYLPNYLVNYVAILLIIAFQSIVRYHQHQHYKHSEHRRPKEGIIFCNVTREDADKGIIDVLKYFANYFFYKFGLEICYITTAITISVRVDAYSILYAIFLAALLLMNRRNNARVWPVYVLILTVLLPLQYMSSLGFLLGLCTEYPWKEMLKPSLQYWLFLPSY-LHPPPAIILIADFFQLLFVCLQWQVFNVEQGSQSTNYAGGDNKDILPEVEASLEIPVPDFTTTMASYLDVAKYAVFYHLFWVTMAIVFFAGTNRINIFGLGYVIIVFCFMWFGREFLLKPLRKLLWWWNFLIGYTFIVLLVKISLQLVGCVYMDGVGIAH-CWAVKLFGITCLNSFPKEQHG--------NCEADKNGLGWDVICFAFLLLQRRVYSSHYFRHIVAELEAQRRLASRGAELINRILIREVLLQKERETEVLYTIKKKMEHLKAKQAGLKKSFHEPDEHFQAIRSGDYYLF--------------------------------------------------EDETEEVPESPDQGPTTSLNI------GRSERSGSED----KALGPLQLLSTAIDSGTDTAL----------------------------------------EKAREETDQPVSQHDST---------------PSGDK-------HVAIV-MGT--SVDKVEDEETTKPKESLCSKISNSFSLFIAILVSMANWLIKFFNRISRNYRRVAYTLTDDMRKEKLKIQAEKLTFLSLSAMEEGITTVDSKEAVTRAAEDIGVNKIAVEVDTPQETDIRKSFTKTNLQDIDNAEEENEFELAQPVFYRLLVAYYYMLISRSELVCYFLIVLNQMMSASLLSMPLPIMVFLWGMLSVPRPSKTFWVTVITYTEAIVVLKYLFQFTFFPWNDDDNSKNWKNNPFWPPRILGIEKQDYYAMYDLALLLVLFIHRTILKRYGLWKDAEDITADLAKAEGKELSPPASPQMHDERKFAAAAATAAAVPEKQEYDFDAGQESEVDVPLKKKMIVTQDPKDNSPHITTLEPEPAEETVQKKKFVSVMKPFQNFYRQMTNSAYNAVVDVYAPMFVCDFLAFLIVVFGYWAFGPVQSGEGSVTTYLEENRVPIPFLVMLVVQFMFIIIDRALFLRKCVHGKFIFQVSLVIIVHIWLFFILPAITNRMFIKNVPAMLWYFVKCIYFALSAHQIRSGYPTRILGNFLTKNYSYLNLFLFKGFLVIPFLLELRALMDWMWTDTTLALGSWLQMEDIYANIFVLKCWRHAEATYPTPRALKRKSTIKYGVGGLLLLLIIFIIWFPLVLFSFANTVYEVNPPKTCTVRISLGGYQPLFKMTVQQADIFALDESQYKLLHKFYDTTPRASSFLTSYDPQDITVITINGESTSVWGISPPSQKKLIRDLMDAKHMDMDLDVSFTRGKRSPQSPGTFSKQFQVT----LTNDTASKLAQIISGGNSSQLVAIPKLFYPFMRLQNNGIVSVVHPLMKEKEEPDIYLGFRSGNISKSSGRVDWWYVSEETDLNIWKPNS---KSNASRLILVTFNDRIAPATFS-LITGYGIAGLYVSFILLIARFLRMGTINMHPSIMFRELPFVDRILKLTLDIYLVREMHEFRLEEDLYAKLIFLYRSPETLIKWTRR 2080
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A0L8GEL3 (Piezo-type mechanosensitive ion channel component OS=Octopus bimaculoides OX=37653 GN=OCBIM_22035390mg PE=3 SV=1) HSP 1 Score: 850.121 bits (2195), Expect = 0.000e+0 Identity = 587/1756 (33.43%), Postives = 891/1756 (50.74%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSM-----EIIDNAKWLGLEKLENFQL--HILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVI--PKLRQWLYLPNYKVSPVPGKIL-ADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQR-LLEGFQKSIH---KDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKP--ELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXXXXXXXXXLRVNLDMLPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSN--GNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEE----EKKLVKSHVLS-----------TFIEIDEKLGKEIEKI-------------VKDGRKSVS----EDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEH-RIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIK----------------------------------------ISNEEEVN------------------HIQPLKPQSAMRT--GIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICER--RSSDSKTT-EKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTL-SEATALLKDHNQTYLNLTLS----MKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
+WRL E H K + I+ V +V A++ + ++I+ + + +++ L + +A +++ K +Q+ + + +W NC+ + + M E I+N W+GLEK+++ L +++ + AIL+ A IVRYHQ Q YK + ++PK +IF V + + D+LKY N+ F K GLE+ +I T + +R+D YS++Y + L L++ R +W Y++ L +LLP+QY+ +G GLC EYP + P L+ WL+LP+Y + P P IL ADF Q +FV LQ+QVF +E+ +S ++ + +L + S+ DF + +SY+D K+ VFY +W+T+AI+F G I +FGLGY++I F ++W G+ L+ + L+ N ++ Y F+V+L K QL+GCV+M+ + CW V LF I C+N E G C + +GL WDV+CF F++LQR ++++ F + +L Q + +SRGA LIN +++ + QK+ E + L I++K++ ++ +QA K E +EH+ +RSGDYYLF ED++ + ++ S+ I E+SG +D L PLQL++ + G A+ E+ RE + + + HD++ PS ++ + AIV GT SVD V + + ES N L + + S L FN +R Y R L + EK +++ L+ T ++ E + + E I D RKS + +D + +++ F ++ F+ LL+++ + I SE CYFL+++N ++S +LLS+P P +VF WGMLSVPRPSK FW+ +ITYTE ++V KY+ QF N ++ + +P P ILGIEK YA+ D+ LL LF+HR+ LK GLW+D + D+ E EV+ HI L+P+ A T KF + +K + FY +MTN N VDVYA MF+C+F A LI++ GY++FGP G +++ N+ P+PF+ M++ QF+FIIIDRALFLRK V GKF+FQ+ VI++H WLFF LP IT R F P L YF+KC+YFALS++Q+RSGYP RILGNFLT+NY+Y NL FK ++ IPFL ELR +MDWMWTDT++AL W+++ED++ IFVLKCWR +E YPT R R+ KY VGGLLL W PL L SF T + NPP CT IS+GGY PLF ++ ++ +L + + + + Y + +L S++ D+T I+I+G S VW I+PPS +KL L + + +++ R RS S T K + T L + L + I SS +V I +F F+ + S L+K+ + + L K WW + E + N K + S L + F++R++ F L + YGI G+Y ++I + R LR ++ I ELP VDRIL L +IYLVRE FRLEE L AKLIFLYRS ET+IKWTR
Sbjct: 465 LWRLTEIHIYKVVGFTIMVVAAKEVSAISAVYVIILALFLLLVKCRLLLSHILQIYTALVLLAKTSFQMSVARVTDWENNCTDTWSNSTDEMDYPFNETINNNIWIGLEKVDSNYLPNYLVNYVAILLIIAFQSIVRYHQHQHYKHSEHRRPKEGIIFCNVTREDADKGIIDVLKYFANYFFYKFGLEICYITTAITISVRVDAYSILYAIFLAALLLMNRRNNARVWPVYVLILTVLLPLQYMSSLGFLLGLCTEYPWKEMLKPSLQYWLFLPSY-LHPPPAIILIADFFQLLFVCLQWQVFNVEQGSQSTNYAGGDNKDILPEVEASLEIPVPDFTTTMASYLDVAKYAVFYHLFWVTMAIVFFAGTNRINIFGLGYVIIVFCFMWFGREFLLKPLRKLLWWWNFLIGYTFIVLLVKISLQLVGCVYMDGVGIAH-CWAVKLFGITCLNSFPKEQHG--------NCEADKNGLGWDVICFAFLLLQRRVYSSHYFRHIVAELEAQRRLASRGAELINRILIREVLLQKERETEVLYTIKKKMEHLKAKQAGLKKSFHEPDEHFQAIRSGDYYLF--------------------------------------------------EDETEEVPESPDQGPTTSLNI------GRSERSGSED----KALGPLQLLSTAIDSGTDTAL----------------------------------------EKAREETDQPVSQHDST---------------PSGDK-------HVAIV-MGT--SVDKVEDEETTKPKESLCSKISNSFSLFIAILVSMANWLIKFFNRISRNYRRVAYTLTDDMRKEKLKIQAEKLTFLSLSAMEEGITTVDSKEAVTRAAEDIGVNKIAVEVDTPQETDIRKSFTKTNLQDIDNAEEENEFELAQPVFYRLLVAYYYMLISRSELVCYFLIVLNQMMSASLLSMPLPIMVFLWGMLSVPRPSKTFWVTVITYTEAIVVLKYLFQFTFFPWNDDDNSKNWKNNPFWPPRILGIEKQDYYAMYDLALLLVLFIHRTILKRYGLWKDAEDITADLAKAEGKELSPPASPQMHDERKFAAAAATAAAVPEKQEYDFDAGQESEVDVPLKKKMIVTQDPKDNSPHITTLEPEPAEETVQKKKFVSVMKPFQNFYRQMTNSAYNAVVDVYAPMFVCDFLAFLIVVFGYWAFGPVQSGEGSVTTYLEENRVPIPFLVMLVVQFMFIIIDRALFLRKCVHGKFIFQVSLVIIVHIWLFFILPAITNRMFIKNVPAMLWYFVKCIYFALSAHQIRSGYPTRILGNFLTKNYSYLNLFLFKGFLVIPFLLELRALMDWMWTDTTLALGSWLQMEDIYANIFVLKCWRHAEATYPTPRALKRKSTIKYGVGGLLLLLIIFIIWFPLVLFSFANTVYEVNPPKTCTVRISLGGYQPLFKMTVQQADIFALDESQYKLLHKFYDTTPRASSFLTSYDPQDITVITINGESTSVWGISPPSQKKLIRDLMDAKHMDMDLDVSFTRGKRSPQSPGTFSKQFQVT----LTNDTASKLAQIISGGNSSQLVAIPKLFYPFMRLQNNGIVSVVHPLMKEKEEPDIYLGFRSGNISKSSGRVDWWYVSEETDLNIWKPNS---KSNASRLILVTFNDRIAPATFS-LITGYGIAGLYVSFILLIARFLRMGTINMHPSIMFRELPFVDRILKLTLDIYLVREMHEFRLEEDLYAKLIFLYRSPETLIKWTRR 2077
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Match: A0A0L8GD87 (Piezo-type mechanosensitive ion channel component OS=Octopus bimaculoides OX=37653 GN=OCBIM_22035390mg PE=3 SV=1) HSP 1 Score: 850.121 bits (2195), Expect = 0.000e+0 Identity = 587/1756 (33.43%), Postives = 891/1756 (50.74%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSM-----EIIDNAKWLGLEKLENFQL--HILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVI--PKLRQWLYLPNYKVSPVPGKIL-ADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQR-LLEGFQKSIH---KDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKP--ELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXXXXXXXXXLRVNLDMLPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSN--GNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEE----EKKLVKSHVLS-----------TFIEIDEKLGKEIEKI-------------VKDGRKSVS----EDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEH-RIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIK----------------------------------------ISNEEEVN------------------HIQPLKPQSAMRT--GIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICER--RSSDSKTT-EKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTL-SEATALLKDHNQTYLNLTLS----MKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
+WRL E H K + I+ V +V A++ + ++I+ + + +++ L + +A +++ K +Q+ + + +W NC+ + + M E I+N W+GLEK+++ L +++ + AIL+ A IVRYHQ Q YK + ++PK +IF V + + D+LKY N+ F K GLE+ +I T + +R+D YS++Y + L L++ R +W Y++ L +LLP+QY+ +G GLC EYP + P L+ WL+LP+Y + P P IL ADF Q +FV LQ+QVF +E+ +S ++ + +L + S+ DF + +SY+D K+ VFY +W+T+AI+F G I +FGLGY++I F ++W G+ L+ + L+ N ++ Y F+V+L K QL+GCV+M+ + CW V LF I C+N E G C + +GL WDV+CF F++LQR ++++ F + +L Q + +SRGA LIN +++ + QK+ E + L I++K++ ++ +QA K E +EH+ +RSGDYYLF ED++ + ++ S+ I E+SG +D L PLQL++ + G A+ E+ RE + + + HD++ PS ++ + AIV GT SVD V + + ES N L + + S L FN +R Y R L + EK +++ L+ T ++ E + + E I D RKS + +D + +++ F ++ F+ LL+++ + I SE CYFL+++N ++S +LLS+P P +VF WGMLSVPRPSK FW+ +ITYTE ++V KY+ QF N ++ + +P P ILGIEK YA+ D+ LL LF+HR+ LK GLW+D + D+ E EV+ HI L+P+ A T KF + +K + FY +MTN N VDVYA MF+C+F A LI++ GY++FGP G +++ N+ P+PF+ M++ QF+FIIIDRALFLRK V GKF+FQ+ VI++H WLFF LP IT R F P L YF+KC+YFALS++Q+RSGYP RILGNFLT+NY+Y NL FK ++ IPFL ELR +MDWMWTDT++AL W+++ED++ IFVLKCWR +E YPT R R+ KY VGGLLL W PL L SF T + NPP CT IS+GGY PLF ++ ++ +L + + + + Y + +L S++ D+T I+I+G S VW I+PPS +KL L + + +++ R RS S T K + T L + L + I SS +V I +F F+ + S L+K+ + + L K WW + E + N K + S L + F++R++ F L + YGI G+Y ++I + R LR ++ I ELP VDRIL L +IYLVRE FRLEE L AKLIFLYRS ET+IKWTR
Sbjct: 456 LWRLTEIHIYKVVGFTIMVVAAKEVSAISAVYVIILALFLLLVKCRLLLSHILQIYTALVLLAKTSFQMSVARVTDWENNCTDTWSNSTDEMDYPFNETINNNIWIGLEKVDSNYLPNYLVNYVAILLIIAFQSIVRYHQHQHYKHSEHRRPKEGIIFCNVTREDADKGIIDVLKYFANYFFYKFGLEICYITTAITISVRVDAYSILYAIFLAALLLMNRRNNARVWPVYVLILTVLLPLQYMSSLGFLLGLCTEYPWKEMLKPSLQYWLFLPSY-LHPPPAIILIADFFQLLFVCLQWQVFNVEQGSQSTNYAGGDNKDILPEVEASLEIPVPDFTTTMASYLDVAKYAVFYHLFWVTMAIVFFAGTNRINIFGLGYVIIVFCFMWFGREFLLKPLRKLLWWWNFLIGYTFIVLLVKISLQLVGCVYMDGVGIAH-CWAVKLFGITCLNSFPKEQHG--------NCEADKNGLGWDVICFAFLLLQRRVYSSHYFRHIVAELEAQRRLASRGAELINRILIREVLLQKERETEVLYTIKKKMEHLKAKQAGLKKSFHEPDEHFQAIRSGDYYLF--------------------------------------------------EDETEEVPESPDQGPTTSLNI------GRSERSGSED----KALGPLQLLSTAIDSGTDTAL----------------------------------------EKAREETDQPVSQHDST---------------PSGDK-------HVAIV-MGT--SVDKVEDEETTKPKESLCSKISNSFSLFIAILVSMANWLIKFFNRISRNYRRVAYTLTDDMRKEKLKIQAEKLTFLSLSAMEEGITTVDSKEAVTRAAEDIGVNKIAVEVDTPQETDIRKSFTKTNLQDIDNAEEENEFELAQPVFYRLLVAYYYMLISRSELVCYFLIVLNQMMSASLLSMPLPIMVFLWGMLSVPRPSKTFWVTVITYTEAIVVLKYLFQFTFFPWNDDDNSKNWKNNPFWPPRILGIEKQDYYAMYDLALLLVLFIHRTILKRYGLWKDAEDITADLAKAEGKELSPPASPQMHDERKFAAAAATAAAVPEKQEYDFDAGQESEVDVPLKKKMIVTQDPKDNSPHITTLEPEPAEETVQKKKFVSVMKPFQNFYRQMTNSAYNAVVDVYAPMFVCDFLAFLIVVFGYWAFGPVQSGEGSVTTYLEENRVPIPFLVMLVVQFMFIIIDRALFLRKCVHGKFIFQVSLVIIVHIWLFFILPAITNRMFIKNVPAMLWYFVKCIYFALSAHQIRSGYPTRILGNFLTKNYSYLNLFLFKGFLVIPFLLELRALMDWMWTDTTLALGSWLQMEDIYANIFVLKCWRHAEATYPTPRALKRKSTIKYGVGGLLLLLIIFIIWFPLVLFSFANTVYEVNPPKTCTVRISLGGYQPLFKMTVQQADIFALDESQYKLLHKFYDTTPRASSFLTSYDPQDITVITINGESTSVWGISPPSQKKLIRDLMDAKHMDMDLDVSFTRGKRSPQSPGTFSKQFQVT----LTNDTASKLAQIISGGNSSQLVAIPKLFYPFMRLQNNGIVSVVHPLMKEKEEPDIYLGFRSGNISKSSGRVDWWYVSEETDLNIWKPNS---KSNASRLILVTFNDRIAPATFS-LITGYGIAGLYVSFILLIARFLRMGTINMHPSIMFRELPFVDRILKLTLDIYLVREMHEFRLEEDLYAKLIFLYRSPETLIKWTRR 2068
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2-like [Source:NCBI gene;Acc:103047759]) HSP 1 Score: 415.231 bits (1066), Expect = 1.142e-116 Identity = 229/608 (37.66%), Postives = 357/608 (58.72%), Query Frame = 2
Query: 4082 AMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERR-SSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDH---NQTYLNLTLSMKKENEA-----RWWEIQEIVAGE-TYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHN 5872
+ T ++ PI+Q F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P F+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+R+F+ QL YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IFVLKCWR SE YP RG ++ KY +GG+++ W PL S + + V N P++ + +I++GG+ P+F +++N LK + + F K Y +L ++ A DVT+ ++G+S+ +WTI+PPS + L L + + M +R S +K M +H LD N ++ L+ + ++ V+ I +FP F+ R S++ A DH + Y ++TL +K+ + + WW + + AG S K ++ + L +++FS++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2229 TIHTTLEIYIPIRQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNMVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKDVTEAEFLKFMNSYNYIPGAMQFLEAYTAEDVTEAELEGNSNSLWTISPPSRKSLMEVLSKEDQFPVTMSWTIQRNLSLGAKAEVAMDKHVT--YLDTNTRQELINLLNGTRNKAVI-IKEVFPCFI----RAPSDSNAKPIDHLYGDNGYKDITLDLKRSDNSSGEIQEWWIVDQPSAGMIDMKSGVKTEQKREAGLRLYVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2824 HSP 2 Score: 192.586 bits (488), Expect = 2.373e-48 Identity = 158/560 (28.21%), Postives = 276/560 (49.29%), Query Frame = 2
Query: 980 HFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFA--------NSSM--EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKL-NLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVL-WLPYMIFLGILLPVQYVICVGLPPGLCIEYPL-----NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIH--GKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQ 2578
H K + I++V + +V N + ++ PF + + + V + I++ KM+YQ+ Q + CS N+ NS++ +D A W+GL+K ++ +L A + + Y FY++ N P + IF + + + KY +N+ F K GLE F+ V V R+D ++ + L+ L +R L W Y FL +L QY+IC+G+PP C +YP ++ + +WLYLP+++ P +L DF+ + LQ +VF+ E D+ ++ + F Q + DFI +S Y+D LK ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++ + ++ YN VI K I + C ++ L T CW++ LF++ C I+G + A+KQC S +G+ WD +CF ++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K ++ ++R++ +I+ RQ +
Sbjct: 936 HVIKIVSSYIIWVSVKEVSLFNYVFLVSWAFALPFSQFRPLASSVCTVWTCVIIVCKMLYQLTSIQPETYSKICSMPHNYTELQRIDMNNSTLYSSPVDPANWVGLKKFSPLLENLRNNLLMLALLA-FEVTVYRHQDFYRMRNNLTAPVSRTIFHNITRQHLDDGIVNCAKYFINYFFYKFGLETCFLLAVNVIGQRMDFCAMFHAFGLIAVLYQRRRKAIALVWPKYCCFLACMLTFQYLICIGIPPAACSDYPWRNPSSSMDSNVVKWLYLPDFRTKPNSLFLLYDFMLLLCASLQRRVFEEEDDSAVRLLAGDNVEICRDLDAASFSQHNPVPDFIHCRS-YLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKSILHYWDFLIAYNVFVITMKNILSIAACGYIKALVTNH-CWLIQLFSLACT------IKGYSRPEQQANKQCELPSDEAGIIWDSICFASLLLQRRVFMSYYFLHVVADIRSSQVLASRGAELFQATIVKAVKARIEEEKKSMDLLKRQMDRIKSRQQK 1486 HSP 3 Score: 117.857 bits (294), Expect = 1.147e-25 Identity = 61/151 (40.40%), Postives = 88/151 (58.28%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRD 4003
EE + + F S+ + L + + + +SE CY ++I+NH++S ++ +L P L+F W MLSVPRPSK FW+ I YTE+ IV KY QF N + + P P I+G+EK Y D++QLL LF HRS LK +GLW +
Sbjct: 1959 EELEESERFYSSQPQILQLCYALYNMLVAHSEMVCYLVIILNHMISASVATLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFN-QNIELDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCHGLWDE 2108
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo2a.2 (piezo-type mechanosensitive ion channel component 2-like [Source:NCBI gene;Acc:103047759]) HSP 1 Score: 409.838 bits (1052), Expect = 4.963e-115 Identity = 229/600 (38.17%), Postives = 355/600 (59.17%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSP--PTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERR-SSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDH---NQTYLNLTLSMKKENEA-----RWWEIQEIVAGE-TYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHN 5872
PI+Q F+ + + + + DVY +MFL + +II+ G+++FG + + + ++ P F+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+R+F+ QL YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IFVLKCWR SE YP RG ++ KY +GG+++ W PL S + + V N P++ + +I++GG+ P+F +++N LK + + F + C F P +L ++ A DVT+ ++G+S+ +WTI+PPS + L L + + M +R S +K M +H LD N ++ L+ + ++ V+ I +FP F+ R S++ A DH + Y ++TL +K+ + + WW + + AG S K ++ + L +++FS++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR
Sbjct: 2092 PIRQ---FFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHS-AAADITSSLSEDQVPEAFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVILVFGIHFWMFFILPGVTERRFSQNMVAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNKPLDVSVTITLGGFQPIFTMSAQQNQLKDVTEAEFLNLM-CNICFFPQGAMQFLEAYTAEDVTEAELEGNSNSLWTISPPSRKSLMEVLSKEDQFPVTMSWTIQRNLSLGAKAEVAMDKHVT--YLDTNTRQELINLLNGTRNKAVI-IKEVFPCFI----RAPSDSNAKPIDHLYGDNGYKDITLDLKRSDNSSGEIQEWWIVDQPSAGMIDMKSGVKTEQKREAGLRLYVFSDKVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREK 2678 HSP 2 Score: 190.274 bits (482), Expect = 9.614e-48 Identity = 158/560 (28.21%), Postives = 276/560 (49.29%), Query Frame = 2
Query: 980 HFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFA--------NSSM--EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKL-NLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVL-WLPYMIFLGILLPVQYVICVGLPPGLCIEYPL-----NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGF-QKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIH--GKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQ 2578
H K + I++V + +V N + ++ PF + + + V + I++ KM+YQ+ Q + CS N+ NS++ +D A W+GL+K ++ +L A + + Y FY++ N P + IF + + + KY +N+ F K GLE F+ V V R+D ++ + L+ L +R L W Y FL +L QY+IC+G+PP C +YP ++ + +WLYLP+++ P +L DF+ + LQ +VF+ E D+ ++ + F Q + DFI +S Y+D LK ++F + +W L IIF TG I++F +GYL+ F +L G +L+ KS++ + ++ YN VI K I + C ++ L T CW++ LF++ C I+G + A+KQC S +G+ WD +CF ++LQR +F + FL V D+ +SRGA L I+K+++ + + E+K ++ ++R++ +I+ RQ +
Sbjct: 849 HVIKIVSSYIIWVSVKEVSLFNYVFLVSWAFALPFSQFRPLASSVCTVWTCVIIVCKMLYQLTSIQPETYSKICSMPHNYTELQRIDMNNSTLYSSPVDPANWVGLKKFSPLLENLRNNLLMLALLA-FEVTVYRHQDFYRMRNNLTAPVSRTIFHNITRQHLDDGIVNCAKYFINYFFYKFGLETCFLLAVNVIGQRMDFCAMFHAFGLIAVLYQRRRKAIALVWPKYCCFLACMLTFQYLICIGIPPAACSDYPWRNPSSSMDSNVVKWLYLPDFRTKPNSLFLLYDFMLLLCASLQRRVFEEEDDSAVRLLAGDNVEICRDLDAASFSQHNPVPDFIHCRS-YLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKSILHYWDFLIAYNVFVITMKNILSIAACGYIKALVTNH-CWLIQLFSLACT------IKGYSRPEQQANKQCELPSDEAGIIWDSICFASLLLQRRVFMSYYFLHVVADIRSSQVLASRGAELFQATIVKAVKARIEEEKKSMDLLKRQMDRIKSRQQK 1399 HSP 3 Score: 117.087 bits (292), Expect = 1.739e-25 Identity = 61/151 (40.40%), Postives = 88/151 (58.28%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRD 4003
EE + + F S+ + L + + + +SE CY ++I+NH++S ++ +L P L+F W MLSVPRPSK FW+ I YTE+ IV KY QF N + + P P I+G+EK Y D++QLL LF HRS LK +GLW +
Sbjct: 1806 EELEESERFYSSQPQILQLCYALYNMLVAHSEMVCYLVIILNHMISASVATLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFGFFPFN-QNIELDKSKPFHPPNIIGVEKKEGYVHYDLVQLLALFFHRSILKCHGLWDE 1955
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:HGNC Symbol;Acc:HGNC:26270]) HSP 1 Score: 408.297 bits (1048), Expect = 1.751e-114 Identity = 234/603 (38.81%), Postives = 351/603 (58.21%), Query Frame = 2
Query: 4085 MRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTES-LKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLK-AIEANQSSY---VVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
++ ++ PI+Q F+ + + + DVY +MFL + +II+ G+++FG G + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP +T+R+F+ QL YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + IPFL ELR VMDW+WTDT+++L W+ VED++ IFVLKCWR SE YP RG ++ KY +GG+++ W PL S + + V N P++ + S+++GG+ P+F +++ NL S+ FD + + S +L ++ D+T ++GSS+ +WTI+PPS + L L +S + M +R S +E M LD+ K L K IE N + V I +IFPR+L R S++ A L + T ++L L+ +++ WW + + G + KI L ++IFS++VS G L + YGI+G+Y + + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE L AKLIFLYRS ETMIKWTR K
Sbjct: 2099 LKKAMEIYLPIRQ---FFYNLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKH-QGGADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVMGKVIFQVVLVFGIHFWMFFILPGVTERRFSQNRIAQLWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLIPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFVLKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVMLLICIVWFPLLFMSLVKSVAGVVNTPLDVSVSLTLGGFQPIFTMSAQQKNLNSITSAKFDNFVKHFSKNSFAVQFLEAYVYQDLTVAHLEGSSNSMWTISPPSKKNLIGMLNQADSDFPLTMTWSIQRNLSLGAKSE-MATGKKIINLDKETKIQLAKLLIETNSTDAHKKPVCIKSIFPRYL----RAPSDSNAKLIEQLSTDIDLFLNRAEDSNKEWWVVNQTKFGLLKLESVKI--NDSPRLELYIFSDQVSPPSLGFL-AGYGIMGLYMSVVLVIGKFVREFFSGISHTIMFEELPNVDRILKLCTDIFLVRETGELDLEEDLYAKLIFLYRSPETMIKWTREKK 2689 HSP 2 Score: 211.46 bits (537), Expect = 3.627e-54 Identity = 164/583 (28.13%), Postives = 284/583 (48.71%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGN----FANSSM---EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL---------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGFQKSIHK---DFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADK-QCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGD 2629
IW L E H K + I+ VC+ +V +N +L+ P+ + + + V + I+ KM YQ++ + N+ C + N + N S+ + +D A W+GL K + ++ I+ A + HQ F + N P + IF ++ + +KY +N+ F K G+E+ F+ V V R+D YS+++ L + +R +W Y FL ++ QY +C+G+PP C +YP NVI +WL+LP++ P +L DF+ + LQ QVF E + D+ ++ + L+ S+H DFI +S Y+D LK ++F + +W L IIF TG I++F +GYL+ F +L G +L+ K L+ + ++ YN VI K IF L+ C +++ ++ K CW++ L ++ C I+ N D+ +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K++ + + E K + +++R++ +I+ RQ + K + + SGD
Sbjct: 828 IWWLLEMHIVKIVPFYIILVCVKEVSLLNYVLLASWAFALPYRQFRTLASSICIVWTCVIITCKMFYQLETIEPRNYSVECLKPENITDVYINQSLLYTDPVDPANWVGLRKSKELLTYLTNDLLIVAILAFEVTIYRHQEYFRRHNKLSPPPSRTIFHDITRQHLDNGIINCIKYFINYSFYKFGVEVCFLLAVNVIGQRMDFYSMLHAFALAAVMYRRRRKAIAEIWPKYCCFLACMITFQYAMCIGIPPAACSDYPWRFPSSTTNSNVI----KWLFLPDFSTRPNSMFLLYDFMLLLSASLQRQVFDEENKAAVRLMAGDNVEICRD--LDAASFSVHNPVPDFIHCRS-YLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKKLLHYWDFLIAYNVFVITMKNIFSLLACGYIDSMQ-KNSCWLIQLLSLACT------IKEYTPPNTDRCDLPKDEAGIIWDSICFSFLLLQRRVFMSYYFLHVVADIRAGQILASRGAELFQASIVKAVRARLEEENKSMEQLKRQMDRIKTRQQKFKKGKEKMLSMTQESGD 1396 HSP 3 Score: 113.235 bits (282), Expect = 2.886e-24 Identity = 65/167 (38.92%), Postives = 94/167 (56.29%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW--RDHSEFYKDIKISNEE 4045
EE + F +++ L + + + +SE Y ++I+NH++S ++++L P L+F W MLSVPRPSK FW+ I YTE+ IV KY QF+ N + ++ P P I+G+EK Y D+IQLL LF HRS LK +GLW D KD + EE
Sbjct: 1819 EELEGSERFYKTQPLGLQLCYALYNLLVAHSEMVSYLVIILNHMISASMVTLVLPILIFLWAMLSVPRPSKRFWMTAIVYTEVTIVIKYFFQFSFFPFNQNMIDRNK--PYHPPNIIGVEKKDGYVHYDLIQLLTLFFHRSILKCHGLWDEDDPKAKKKDTPLHREE 1983
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:ZFIN;Acc:ZDB-GENE-041111-255]) HSP 1 Score: 366.311 bits (939), Expect = 1.301e-101 Identity = 221/611 (36.17%), Postives = 353/611 (57.77%), Query Frame = 2
Query: 4067 LKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFIC-FWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSL-EKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATA-LLKDHNQTYLNLTLSMKKENE------ARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRH 5869
LK +SA +G+ R+ + +F+ + + + DVYA+MFL + +II+ G+++FG + + A + ++ P F+ M++ QF ++IDRAL+LRK V GK +FQI V IH W+FF LP +T+R FN F QL YF+KC+YF LS+YQ+R GYP RILGNFLT+ YN+ NL F+ + +PFL ELR VMDW+WTDT+++L +WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ FF IC W PL S + + V N P++ T ++ +GGY PLF ++ +++ + ++ + E + + + ++ + D+ +I+GSS VW I+PPS E +K L S + + + +R + T E + N + L ++ + V++ +FP ++ A ++ + L + + Y N+TLS+ ++ WW+I ++ + +P + IF+++VS G L + YGI+G+Y + + V + +R F+S+IS+ I EELP VDRIL L +I+LVRE LEE+L +KLIFLYRS ETMIKWTR
Sbjct: 1881 LKLKSAFISGV--RSVYRPTHRFFHNILHAEYRAATDVYALMFLTDVVDFIIIVFGFWAFGKHSAAADIA-STLSEDQVPEAFLVMLLIQFSTMVIDRALYLRKAVLGKLIFQIILVFGIHLWMFFILPAVTERMFNQNFVAQLWYFVKCIYFTLSAYQVRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIV-FFLICIIWFPLLFISLVRSVVGVVNHPVDVTVTVKLGGYEPLFTMSVQQQSIQPFTEADYNHLTELFGSNAVAMQFITLYSYEDIVTANIEGSSGSVWRISPPSRQEVIKELLGSPADMTLRLAWNFQRDLNKGGTVENTFDKHSINLEPGNPVRADLASLLVGNRTEPVRVPHMFPNYIRAPNGAEAKPVSQLYEGDEEGYQNVTLSLMRDGSLNGSGAQEWWDISVADCDQSSGACGVLP--------MIIFNDKVSPPSLGFL-AGYGIMGLYVSVVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEELYSKLIFLYRSPETMIKWTRE 2478 HSP 2 Score: 194.512 bits (493), Expect = 5.350e-49 Identity = 172/641 (26.83%), Postives = 309/641 (48.21%), Query Frame = 2
Query: 923 KLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVM--VTALFVCSASIVILKMIYQIKIFQTFNWLTNCS---------QYGNFANSSM--EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLN----------VIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-------SDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCS--SVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHG---KPELNE--------------------------------HYLVMRSGDYYLF 2641
K + TL Q +WR+ E H K + +V+V +++ MN++L+++ P+ R + ++ ++VC I++ KM+YQ+ I + NC+ + NS++ + +D A W G K + +L+ V HQ+ Y+ P IF + + +KY LN+ F K GLE+ F+ TV V R++ + + L+ ++ +R + +W Y +FL I + QY++CVG+PP LCI+YP + + LY V +ADF+ + Q++VF+ EK+++ ++ + RL F + +FI+ +S Y+D +K +VF + +W LA++F TG I++FGLGYLL +F +L G +LI + + + + ++ YN VI++K I ++ CVF+ ++ + CW++ LF++ C ++ ++ DK+CS +G+ WD +CFFF++LQR +F + FL V DL + +SRG L I+K++ K++E+K + +++ +++I +Q ++ KP E H V+ SGDYYLF
Sbjct: 731 KFSDILTLIQAFLWRILELHILKIVAFFVVWVALLEPSVMNLVLVVLWSFAMPYARFRPMASCLSTVWVCV--IIVCKMLYQLSIVNPNEYSNNCTVPLSNETSLEMNEIVNSTLYKDPVDPANWFGFRKAATALGYSKNHLLVLLLLVFEATVYRHQVHHYRQLQRSPPTIPAIFPQATRDKLDQGLLPCIKYLLNYSFYKFGLEICFLMTVNVIGQRMNFLVIFHGCWLVAIMVRRRRVAIAKIWSKYCLFLVIFMIYQYILCVGIPPALCIDYPWRWKTSVTINSMLCEHFKCKLYCLCVCVCVCVCVCVADFLLLMCASQQWKVFENEKKEEWMVLGGENNDNPDPMDRL--PFNPA--PNFINCRS-YLDMMKVLVFRYMFWFVLAVVFVTGSTRISVFGLGYLLASFFFLLFGTRLLIKRSCTRLLMWDCLIIYNVTVIISKNILSILACVFVADMQAR-FCWVIQLFSLVCTVKDYYDPASLN----DKECSLPVEEAGIIWDSICFFFLLLQRRVFLSFYFLHVTADLQASARQASRGFELFRASIIKNMRFHKQAEKKSIQQLKNSMQRIRDKQQKYKEGRKPSEREEQPTESQEELERKQRKERKTSKHKEWHRPWIDHATVLHSGDYYLF 1359 HSP 3 Score: 120.168 bits (300), Expect = 2.030e-26 Identity = 63/167 (37.72%), Postives = 97/167 (58.08%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRID---PLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNE 4042
EE F S+++ LL + V +SE CYF++++N+ ++ +++SL P L+F W ML+VPRPSK+FW+ I YTE+++V KY+ QF N E R++ P P ILG+EK+ Y D++QLL LF HRS L+ GLW + + S++
Sbjct: 1591 EELVHSRDFYSSQNRMLKLLFALYNVLACHSELACYFIIVLNNAVTASVISLVLPILIFLWAMLAVPRPSKSFWMTAIVYTEVMVVVKYLFQFGFFPWN--SEYETRLNENKPFFPPRILGLEKTDNYIRYDLLQLLALFFHRSLLQRYGLWDHEGPLEEKVSPSSD 1755
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Match: piezo1 (piezo-type mechanosensitive ion channel component 1 [Source:ZFIN;Acc:ZDB-GENE-041111-255]) HSP 1 Score: 82.0333 bits (201), Expect = 1.530e-15 Identity = 58/235 (24.68%), Postives = 114/235 (48.51%), Query Frame = 2
Query: 4820 YSVGGLLLAFFFICF-WGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPS-LEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMV-RHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENE------ARWWEI 5494
Y +GGL++ FF IC W PL S + + V N P++ T ++ +GGY PLF ++ +++ + ++ + E + + + ++ + D+ +I+GSS VW I+PPS E +K L S + + + +R + T E +H+ + + +L + N++ V +FP ++ A +EA + + + + Y N+TLS+ ++ WW+I
Sbjct: 44 YGMGGLIV-FFLICIIWFPLLFISLVRSVVGVVNHPVDVTVTVKLGGYEPLFTMSVQQQSIQPFTEADYNHLTELFGSNAVAMQFITLYSYEDIVTANIEGSSGSVWRISPPSRQEVIKELLGSPADMTLRLAWNFQRDLNKGGTVENTFDKHSINLEPGNPVRADLASLLVGNRTDRVPH---MFPNYIRAPNG--AEAKPVSQLYEEGYQNVTLSLMRDGSLNGSGAQEWWDI 272
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009619.1 (pep scaffold:Pmarinus_7.0:GL484020:1370:4517:1 gene:ENSPMAG00000008693.1 transcript:ENSPMAT00000009619.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 125.176 bits (313), Expect = 1.378e-32 Identity = 70/193 (36.27%), Postives = 109/193 (56.48%), Query Frame = 2
Query: 5315 AIEANQSSYVVQIDAIFPRFLTAYKRTLSEAT-ALLKDHNQTYLNLTLSMKK-----ENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNK 5875
A++ S I +FP +L A S +L + ++Y ++ L +++ + A WW ++++ P + ++ + +FS+RVS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDR+L L +I+LVRE +LEE L AKLIFLYRS ETMIKWTR +
Sbjct: 13 ALDTFASRVCRLIKNLFPPYLKAPGGPDSTPVRQMLPEGERSYSDVELVLRQGSPASSSHAEWWSLRQL--------RSDCPGRRCDDIRIIVFSDRVSPPSLGFL-AGYGILGLYASVVLVVGKFVREFFSGISHSIMFEELPNVDRVLKLCTDIFLVRETGELQLEEDLYAKLIFLYRSPETMIKWTREKE 196
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO30292 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T173]) HSP 1 Score: 228.024 bits (580), Expect = 1.350e-63 Identity = 114/288 (39.58%), Postives = 168/288 (58.33%), Query Frame = 2
Query: 4355 DRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNF------SPPTDYLMSF----------------EAGDVTQISIDGSSDDVWTITPPS 5152
DR L+LRK V K F +F + H ++F +PY+TKR F P +Y C+YF LS+YQ+RSGYP RILGNFLT++Y + + F+ + IPFL ELR+V+DW+ TDT++ L+HW+++ED++ I+VLKC+R SE + RG + SK++VGGLL+A I W PL S+I + + NPP + TF++S+GGY PLF ++E L+ L D++K + PP + F + G V + I G+S +W I+PPS
Sbjct: 184 DRCLYLRKYVFAKLFFLLFLTVSFHVFMFIVVPYVTKRPFFKNIPAIFMYIFMCMYFGLSAYQVRSGYPTRILGNFLTKSYTLTSGVLFQGFQAIPFLLELRSVLDWVCTDTTLTLYHWLKMEDIYANIYVLKCYRESEKTWFQGRGQKYWMLSKWTVGGLLVALLVIVIWFPLLFMSYINSVYTSNPPQDATFTLSIGGYQPLFRVSAQEQFLERLNNTKIDRIKTQHPGLHQGADTQPPLQVAIIFNCVLKIQIDTFLADYHDRGTVVLVKITGNSSSIWQISPPS 471 HSP 2 Score: 93.5893 bits (231), Expect = 3.016e-19 Identity = 40/83 (48.19%), Postives = 65/83 (78.31%), Query Frame = 2
Query: 5630 IIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKS 5878
IIG+Y ++++ + +R F++ ISY I +E+P+VD++L L +I++VRE+K F+LEE L AKL+FLYRS ET+IKWT++ ++
Sbjct: 496 IIGLYVGFVWLVGKFVRLFFTSISYRIMFDEMPNVDKVLKLCLDIFMVRESKSFKLEEDLFAKLMFLYRSPETLIKWTKYKRA 578 HSP 3 Score: 63.1586 bits (152), Expect = 9.267e-10 Identity = 26/58 (44.83%), Postives = 37/58 (63.79%), Query Frame = 2
Query: 4790 RGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSP 4963
RG + SK++VGGLL+A I W PL S+I + + NPP + TF++S+GGY P
Sbjct: 94 RGQKYWMLSKWTVGGLLVALLVIVIWFPLLFMSYINSVYTSNPPQDATFTLSIGGYQP 151
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO47371 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM5]) HSP 1 Score: 155.992 bits (393), Expect = 4.330e-41 Identity = 104/360 (28.89%), Postives = 181/360 (50.28%), Query Frame = 2
Query: 1388 KPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVI--PKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMN-LLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSR 2458
+P+ ++F+ + ++ +KY N F G E+S + VV +R DV S++Y L L FL L R V+W Y+ FL LLPVQY++ +G PPGLC+ YP + P L WLYL + P +L DF Q +F Q V+ +E+ + ++ G + +++D+ K +F YW+TLA+++ T +++F G++L F +LW GQ + + +K L+R + + YN+L +L K Q++ CV+ + + + C + L ++ C+ ++ + G + + +GL D CF F++ Q IFT++ F V D Q++ + R
Sbjct: 10 EPEPGILFESASRQKADDDMLQCVKYLFNRFFYHFGWEVSLVVMVVNMAVRCDVTSVIYALWLGSFLALGRQSSAVIWPVYVGFLAFLLPVQYLLVLGWPPGLCLAYPWTKVLDPNLSHWLYLTDVSFPSDPKLLLGDFFQLLFACCQENVYGLERYSWTAEETEQSRQTRRGSRVKFSTPDFMWNITWLDFCKVTLFQHMYWVTLAVVYITVQSTVSIFNFGFILWCFFFLWHGQALYLQPRKKLLRLWKLFICYNYLTLLAKVCLQVVACVWQDYVTQYTSNCLPLQLLSMFCLRNSTYSGKPQTGMDC---VAPDDTGLAMDCACFTFLLTQYRIFTSEYFRHVVRDHREQSEMAYR 366
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO47370 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM3]) HSP 1 Score: 137.117 bits (344), Expect = 9.593e-33 Identity = 66/166 (39.76%), Postives = 100/166 (60.24%), Query Frame = 2
Query: 4610 LIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMK------------ECYKNFSPPTDYL 5071
LI + IPFL ELR+V+DW+ TDT++ L+HW+++ED++ I+VLKC+R SE + RG + SK++VGGLL+A I W PL S+I + + NPP + TF++S+GGY PLF ++E L+ L D++K + K+ S P DY+
Sbjct: 503 LIIIDRFQAIPFLLELRSVLDWVCTDTTLTLYHWLKMEDIYANIYVLKCYRESEKTWFQGRGQKYWMLSKWTVGGLLVALLVIVIWFPLLFMSYINSVYTSNPPQDATFTLSIGGYQPLFRVSAQEQFLERLNNTKIDRIKTQHPGLHQGADTQGTKDSSCPRDYI 668 HSP 2 Score: 127.487 bits (319), Expect = 1.057e-29 Identity = 86/269 (31.97%), Postives = 138/269 (51.30%), Query Frame = 2
Query: 3575 FRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPE--HRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWR------DHSEFYKDIKISNEEEVN--------HIQPLKPQSAM------RTGIKFRNPI-KQLKKFYGKMTNRKLNK-RVDVYAIMFLCEFTAMLIIILGYFSF-GPGTDSGGHAIDFIKTNKTP 4306
++ S + ++F + +++ CY L+I+NH++ LLS+P PFLVF WGMLS+PRP+K +WI +ITYT++VIV KY+ +F +N + + DPL I+GIE+ + D++ LL L+ HR LK +GLWR DH E Y+ N + ++ P S +G N I + +K F ++ + ++ VDVYAIMF C+F +II+ + +F P + ++ N P
Sbjct: 222 WKHSHMRVARFSVAFVYALLAHTDIICYLLMILNHMVYACLLSMPLPFLVFMWGMLSIPRPTKRYWITVITYTQIVIVIKYLFKFQFKFINNCNSSDGPDKNDPLCPARIIGIERDSHTSAYDLLLLLALYFHRYSLKVHGLWRDKAAHDDHDELYEPPLSPNSPKSEPTPFAGSRNMAASSPDSEQYQSDVEDSGESLWNKICRSVKAFLNRIYDPEVGSGAVDVYAIMFACQFIIFIIILFSWSAFSSPEPQRQAQFVKIVEENVVP 490
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Match: EDO47369 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMM2]) HSP 1 Score: 93.2041 bits (230), Expect = 1.064e-22 Identity = 40/83 (48.19%), Postives = 65/83 (78.31%), Query Frame = 2
Query: 5630 IIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKS 5878
IIG+Y ++++ + +R F++ ISY I +E+P+VD++L L +I++VRE+K F+LEE L AKL+FLYRS ET+IKWT++ ++
Sbjct: 1 IIGLYVGFVWLVGKFVRLFFTSISYRIMFDEMPNVDKVLKLCLDIFMVRESKSFKLEEDLFAKLMFLYRSPETLIKWTKYKRA 83
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: piezo1 (piezo type mechanosensitive ion channel component 1 [Source:NCBI gene;Acc:101175341]) HSP 1 Score: 440.269 bits (1131), Expect = 9.209e-125 Identity = 290/797 (36.39%), Postives = 439/797 (55.08%), Query Frame = 2
Query: 3638 YSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLN-VLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKD-----------------------IKISNEEEVNHIQPLKPQSAMRTG-------IKFRNPIKQLKK-----FYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFIC-FWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSL-EKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATA-----LLKDHNQTYLNLTLSMKKENEA------RWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKS 5878
+SE CY ++++N+++S +++S+ P LVF W ML++PRPSK FW+ I YTE+++V KYI QF N + ++ P P ILG+EK+ Y D++QLL LF HR+ L L + F D ++ EEE ++ K Q + T +K +K ++ F+ + + K DVYA+MFL + +III G+++FG + + A + ++ P F+ M++ F +IIDRAL+LRK V GK +FQ V+ IH W+FF LP +T+RKFN F QL YF+KC+YF LS+YQ+R GYP RILGNFLT+N+ + NL F+ + +PFL ELR VMDW+WTDT+++L +WM VED++ IF++KC R +E +YP +G ++ KY +GGL++ FF IC W PL S + + V N PI+ T ++ +GGY PLF ++ +++ ++++ + +K+ + ++ + D+ I+GSS VW I+PPS E +K L S L + + +R T E HT K + + NL++A A+ + P F Y R + A A L K YL +TLS+K + + WW+I + E S L + IF+++VS G L + YGI+G+Y + + V + +R F+S+IS+ I EELP VDRIL L +I+LVRE LEE+L +KLIFLYRS ETMIKWTR N++
Sbjct: 1494 HSELLCYLIIVLNNVVSASVISVVLPILVFLWAMLALPRPSKRFWMTAIVYTEVMVVLKYIFQFGFFSWNSAHEMTVNKDRPFFPPRILGLEKTDNYLRYDLLQLLALFFHRALLMVCTL--NLKSFRPDQEALLAKAAALRKKEALVPEEIHLRAKEEEEEMRLRAKKEQLELETDLTVASARLKVYESLKDVQSSPAQNFFKNLMHNKHQASTDVYALMFLTDMVDFVIIIFGFWAFGKHSAAADIA-STLSEDQVPEAFLVMLLIHFSTMIIDRALYLRKAVLGKLIFQGILVLGIHVWMFFILPSVTERKFNQNFVAQLWYFVKCIYFGLSAYQIRCGYPTRILGNFLTKNFGHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIV-FFLICIIWFPLLFISLVRSVVGVVNHPIDVTVTVKLGGYEPLFTMSVQQQSIQPFNNSQYEELTKMFKD-NTAMQFITLYSYEDIVTAQIEGSSGSVWRISPPSRQEVIKELLGSQVDLTLRLAWNFQRDLGKGGTVE----HTFDKYSIDLEPGNLVRAELASLLIGNRTEPVLVPNFFPNYIRAPNGAEAKPVSQLYKGGEDGYLGITLSLKSDRSSNSSGTREWWDI----------AVEGCVPPSCGVLRMVIFNDKVSPPSLGFL-AGYGIMGLYVSVVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCTDIFLVRETGELELEEELYSKLIFLYRSPETMIKWTRENRA 2270 HSP 2 Score: 202.216 bits (513), Expect = 2.129e-51 Identity = 174/612 (28.43%), Postives = 308/612 (50.33%), Query Frame = 2
Query: 893 VNNMVFTATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVM--VTALFVCSASIVILKMIYQIKIFQTFNWLTNCS-----QYGNFANSSM--EIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRY-HQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXX-XXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPL----------NVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK--------SDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLF 2641
V + + + K + + Q +WRL E H K + V+V + + MN++L+++ + PF R + ++ ++VC I+I KM+YQ+ + + NCS NSS+ E +D AKW G+ K + L K I++ V+ Y HQ Y+ P +F S + LKY +N+ F K GLE+ F+ TV V R++ L++ M+ + + +R +W Y +FL I + QY++CVG+PP LC++YP + L +WLYLP++ P G ++ADFV + Q++VF E+ ++ SD + ++ RL +FI+ +S Y+D LK +VF + +W L+++F TG I++FGLGYLL F +L G +++ + ++ + + ++ YN VI++K + ++ CVF+ ++ + CW++ LF++ C ++G + ++ +G+ WD CF ++LQR +F + FL V +L K +SRG L +MK+++ K++E+K L++++R + A V+ SG+YYLF
Sbjct: 728 VMDRLLVLSRKFSEILSKVQVFLWRLLELHILKMVAFFTVWVALQEASVMNLVLVVLWSLATPFCRFRPMASCLSTVWVCV--IIICKMLYQLSVVNPEEYSRNCSTPLTNHTKLLLNSSLYKEPVDPAKWFGIRK-DATALGYSKNHLIVLMLLVFEATVYRHQAHHYRQLQRSPPPIPAVFPSATRDSLDQGLVACLKYLVNYTFYKFGLEICFLMTVNVIGQRMNFLVLIHGCWMVAILVRRRRAAIARIWPKYCLFLSIFMIYQYLLCVGIPPVLCMDYPWRWSNPVLQDWGTLDALIKWLYLPDFFTVPNSGNLMADFVLLMCASQQWKVFDCERTEEWMVLAGENSDEPEPMEGRLFNP-----APNFINCRS-YLDMLKVLVFRYFFWFVLSVVFITGASRISVFGLGYLLGCFFFLLFGTKLMVKRSRTRLILWDCLIIYNVAVIISKSVLSILACVFVFKMQER-FCWVIQLFSLVC------TVKGYYDRDDTCTLPIEEAGILWDGFCFICLLLQRRVFLSFYFLHVSAELQASAKQASRGFELFRASMMKNMDFHKQAEDKSLSQLKRSQTLMSCCAA------------VIHSGEYYLF 1311
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:101174622]) HSP 1 Score: 377.867 bits (969), Expect = 4.789e-105 Identity = 215/585 (36.75%), Postives = 330/585 (56.41%), Query Frame = 2
Query: 4124 LKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEAR-WWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHN 5872
+K+F+ + + + + DVY +MFL + +II+ G+++FG S + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP IT+++FN Q+ YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDTS++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S + + V N P++ + +I++ G+ P+F +++ L ++ K + +N++P D+ + GSS+ +WTI+PPS + L LRS E I + +R S E N L++ K+NL+ + + Q+ FLT K +L + + +A+ WW IV KI ++ + L +++FS++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE + +KLIFLYRS ETMIKWTR
Sbjct: 2053 MKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFG--KHSTADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVLLVFGIHFWMFFILPIITEKRFNENTVAQMWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTSLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVVLLICIVWFPLLFMSLVKSVAGVVNAPLDVSVTITLAGFQPIFTMSAQQKQLWNVTKTAIQWL----ENYTPE----------DLIIAELKGSSNSLWTISPPSRDNLIDMLRSQEEFSITVSWSIQRNLSLGAEAES-AYGKNVMVLNQETKQNLILLLNGAADAANTQV-----IFLTGNKMI------------DIHLTMQRAQNDSGQAQEWW----IVNQTEQSIIPKIGRKHEAGLEIYVFSDQVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHKIMFEELPNVDRILKLCTDIFLVRETGELDLEEDMYSKLIFLYRSPETMIKWTREK 2598 HSP 2 Score: 191.815 bits (486), Expect = 4.052e-48 Identity = 162/604 (26.82%), Postives = 286/604 (47.35%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEII---DNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYP--LNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGFQKSIHK---DFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQ----------------AQHGKPELNEH-------------YLVMRSGDYYLF 2641
IW L E H K + I+ + + +V +N + ++ P+ + + + V + I++ KM+YQ+K + +CS + S+ D W GL+K E+ ++ +L A + HQ+ F N P +IF ++ +KY +N+ F K GLE + V V R+D Y++++ L+ + +R +W Y FL +L QY +C+G+PP C +YP + +WLY+P++ P P ++ DF+ + +Q QVF+ E + D+ ++ R L+ S+H DFI +S Y+D LK ++F + +W L IIF TG I++F +GYL+ F +L G +L+ K ++ + ++ YN VI K I ++ C +++ L CW++ LF++ C I+G K +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E K + +++R++++I+ RQ + G+P + + V+RSGDYYLF
Sbjct: 890 IWWLLEIHIIKIVSCYIILLTLYEVSLLNFVFLVCWAFALPYSQYRPLASSICTVWTCVIIVCKMLYQLKTINPPPF--DCSYVLSEVKESLLYKIPGDPGNWWGLKKTEDLLGYLRNNLLMLALLAFEVTIYRHQLYFRLRNKLSPPAAPIIFHDITRQHLDMGITYFIKYFINYFFYKFGLETCLLLVVNVIGQRMDFYAMLHAFALIAVMYRRRRKAIAEIWSKYCFFLACMLTFQYFVCIGIPPAACKDYPWSFTTDSNVIKWLYIPDFYKKPDPLFLIYDFMLLLCASMQRQVFEDENKAAVRLIAGDNVEIC--RDLDAASFSVHNPVPDFIHCRS-YLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKKILHYWDFLIAYNIFVITMKNILSILACGYIDSLMENN-CWLIQLFSLSCT------IKGYVIKLDTCDIPKNEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRASQVLASRGAELFQATIVKAVKARLEEEHKSVEQLKRQMERIKVRQQKFKRGKDKILSLAQESAEGQPVVQPEEDDDDGMVNPTPTHSVVRSGDYYLF 1481 HSP 3 Score: 118.242 bits (295), Expect = 7.522e-26 Identity = 60/154 (38.96%), Postives = 89/154 (57.79%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRI---DPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRD 4003
EE + D F +++ + + + +SEF CY ++I+NH++S + +SL P +F W MLSVPRPSK +W+ I YTE+ IV KY CQF + +R+ P I+G+EK Y + D++QLL LF HRS LK +GLW +
Sbjct: 1772 EELEQSDHFYQNQPLILQFSYALYNMLVAHSEFVCYLVIIINHMVSASCVSLVLPVTIFLWAMLSVPRPSKRYWMTAIVYTEVTIVIKYFCQFGFFPHS----KNYRLYKNAPYYPANIIGVEKKDGYVLYDLVQLLALFFHRSILKCHGLWDE 1921
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: ENSORLT00000004626.2 (pep primary_assembly:ASM223467v1:7:7477416:7483305:1 gene:ENSORLG00000003710.2 transcript:ENSORLT00000004626.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 345.51 bits (885), Expect = 1.388e-103 Identity = 214/594 (36.03%), Postives = 327/594 (55.05%), Query Frame = 2
Query: 4112 PIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPS----LEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKS 5878
PI+Q F+ + + + + DVYA+MFL + ++ I GY++FG + + + + ++ P F+ M++ QF +I+DRAL+L+K + GK VFQ+ V IH W+FF LP +T+R+FN QL YF+KC+YF LS+YQ++ GYP RILGNFLT+NYNY NL F+ + +PFL ELR VMDW+WTDT+++L W+ VED++ IFVLKCWR SE +YP G ++ KY +GG ++ W PL S + + V N P+E + +S+ GY PLF ++E NL + +LM++EA D+ I + +W+I+P S +E+L + S+ +N++A+ E HT K D+ K ++ ++ N S + D F L +A+ + KE + +WW ++E S+E PK HS + + +F+++VS + G L + +GI+G+Y + + V + +R F++ IS I EELP VDR+L L +I++VRE LEE L KLIFLYRS ETMIK TR S
Sbjct: 25 PIRQ---FFYDIIHPEYSPVCDVYALMFLIDVVNFIVTIYGYWAFGKYS-AVADITESLSEDQVPEAFLVMLLMQFGTMIVDRALYLKKSLLGKCVFQVVLVFGIHFWMFFILPGVTERRFNRNPIAQLWYFVKCIYFGLSAYQIKCGYPNRILGNFLTKNYNYLNLFLFQGFRMVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYANIFVLKCWRESEKKYPHPPGQKKKKVVKYGMGGFIIFALISIIWFPLLFMSLVQSAAGVTNQPVEVSIQLSIAGYEPLFTMSAQEQNLVA-----------SLFLLQSAMQFLMNYEAEDIIVAKIKSDASLLWSISPASRAAMIEELSISSHLNASISMNVEAVGE--------------HT-VKFNDKALKDGIVSMLKGNSSKPSDRPDLQALAFFRPMSIKLQQASG--------------ASDKEAD-QWWVVEE--CSPVLTSSE--PK-CHS-IEIVVFNDKVSPSSLGFL-AGHGIVGLYMSVVLVIGKFVREFFNGISRSIMFEELPCVDRVLKLCTDIFVVRETGEMELEETLFEKLIFLYRSPETMIKMTREKDS 566
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:101174622]) HSP 1 Score: 368.622 bits (945), Expect = 3.132e-102 Identity = 218/606 (35.97%), Postives = 350/606 (57.76%), Query Frame = 2
Query: 4124 LKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTF-VKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSS-DSKTT--EKMVRHTNTKQLDENDKKNLLKAIEANQSSYVV--------------QIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKK-ENEA----RWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHN 5872
+K+F+ + + + + DVY +MFL + +II+ G+++FG S + ++ P PF+ M++ QF +++DRAL+LRK V GK +FQ+ V IH W+FF LP IT+++FN Q+ YF+KC+YF LS+YQ+R GYP R+LGNFLT++YNY NL F+ + +PFL ELR VMDW+WTDTS++L W+ VED++ IF+LKCWR SE YP RG ++ KY +GG+++ W PL S + + V N P++ + +I++ G+ P+F +++ L ++ K + +N++P D+ + GSS+ +WTI+PPS + L LRS E I + +R + DS + ++ HT L + ++ + Q +V+ + + PR++ A + S+AT++ + N+ +++ L+M++ +N++ WW IV KI ++ + L +++FS++VS G L + YGI+G+YA+ + V + +R F+S IS+ I EELP+VDRIL L +I+LVRE LEE + +KLIFLYRS ETMIKWTR
Sbjct: 2167 MKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFG--KHSTADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVLLVFGIHFWMFFILPIITEKRFNENTVAQMWYFVKCIYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTSLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIVVLLICIVWFPLLFMSLVKSVAGVVNAPLDVSVTITLAGFQPIFTMSAQQKQLWNVTKTAIQWL----ENYTPE----------DLIIAELKGSSNSLWTISPPSRDNLIDMLRSQEEFSITVSWSIQRYPNIDSPLMMFDHIIPHTLQLCLKKKKLFYVI-LLNIFQFLFVIFYFIFFKQNLFRKKTLTKLIPRYIRAPSK--SDATSVEQLGNKM-IDIHLTMQRAQNDSGQAQEWW----IVNQTEQSIIPKIGRKHEAGLEIYVFSDQVSPPSLGFL-AGYGIMGLYASVVLVIGKFVREFFSGISHKIMFEELPNVDRILKLCTDIFLVRETGELDLEEDMYSKLIFLYRSPETMIKWTREK 2747 HSP 2 Score: 193.356 bits (490), Expect = 1.335e-48 Identity = 164/618 (26.54%), Postives = 290/618 (46.93%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEII-DNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYP--LNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGFQKSIHK---DFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVA---SGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQ----------------AQHGKPELN--------------------------EHYLVMRSGDYYLF 2641
IW L E H K + I+ + + +V +N + ++ P+ + + + V + I++ KM+YQ+K + +CS F + +I D W GL+K E+ ++ +L A + HQ+ F N P +IF ++ +KY +N+ F K GLE + V V R+D Y++++ L+ + +R +W Y FL +L QY +C+G+PP C +YP + +WLY+P++ P P ++ DF+ + +Q QVF+ E + D+ ++ R L+ S+H DFI +S Y+D LK ++F + +W L IIF TG I++F +GYL+ F +L G +L+ K ++ + ++ YN VI K I ++ C +++ L CW++ LF++ C I+G K A + +G+ WD +CF F++LQR +F + FL V D+ +SRGA L I+K+++ + + E K + +++R++++I+ RQ + G+P + +H ++RSGDYYLF
Sbjct: 838 IWWLLEIHIIKIVSCYIILLTLYEVSLLNFVFLVCWAFALPYSQYRPLASSICTVWTCVIIVCKMLYQLKTINPPPF--DCSYVCTFTSLLYKIPGDPGNWWGLKKTEDLLGYLRNNLLMLALLAFEVTIYRHQLYFRLRNKLSPPAAPIIFHDITRQHLDMGITYFIKYFINYFFYKFGLETCLLLVVNVIGQRMDFYAMLHAFALIAVMYRRRRKAIAEIWSKYCFFLACMLTFQYFVCIGIPPAACKDYPWSFTTDSNVIKWLYIPDFYKKPDPLFLIYDFMLLLCASMQRQVFEDENKAAVRLIAGDNVEIC--RDLDAASFSVHNPVPDFIHCRS-YLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKKILHYWDFLIAYNIFVITMKNILSILACGYIDSLMENN-CWLIQLFSLSC------TIKGYVIKLASSDTCDIPKNEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRASQVLASRGAELFQATIVKAVKARLEEEHKSVEQLKRQMERIKVRQQKFKRGKDKILSLAQESAEGQPVVQPEEDDDDGAQRTKAKPKKKQWWRPWVDHASMVRSGDYYLF 1443 HSP 3 Score: 119.783 bits (299), Expect = 2.513e-26 Identity = 70/199 (35.18%), Postives = 105/199 (52.76%), Query Frame = 2
Query: 3551 EEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRI---DPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLW-RDHSEFYKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKF 4135
EE + D F +++ + + + +SEF CY ++I+NH++S + +SL P +F W MLSVPRPSK +W+ I YTE+ IV KY CQF + +R+ P I+G+EK Y + D++QLL LF HRS LK +GLW D + K+ + +E +P P S R R+ +K F
Sbjct: 1883 EELEQSDHFYQNQPLILQFSYALYNMLVAHSEFVCYLVIIINHMVSASCVSLVLPVTIFLWAMLSVPRPSKRYWMTAIVYTEVTIVIKYFCQFGFFPHS----KNYRLYKNAPYYPANIIGVEKKDGYVLYDLVQLLALFFHRSILKCHGLWDEDDPKERKEASVREKES----EPSSPLSHKR-----RSSTNTMKSF 2068
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Match: PIEZO2 (piezo type mechanosensitive ion channel component 2 [Source:NCBI gene;Acc:101174622]) HSP 1 Score: 173.711 bits (439), Expect = 7.371e-43 Identity = 141/526 (26.81%), Postives = 248/526 (47.15%), Query Frame = 2
Query: 959 IWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCS---QYGNFANSSMEII----------DNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNV-LWLPYMIFLGILLPVQYVICVGLPPGLCIEYP--LNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKK-----SDSHKLVKQRLLEGFQKSIHK---DFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVA---SGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSS 2455
IW L E H K + I+ + + +V +N + ++ P+ + + + V + I++ KM+YQ+K + +CS Q G + + + D W GL+K E+ ++ +L A + HQ+ F N P +IF ++ +KY +N+ F K GLE + V V R+D Y++++ L+ + +R +W Y FL +L QY +C+G+PP C +YP + +WLY+P++ P P ++ DF+ + +Q QVF+ E + D+ ++ + L+ S+H DFI +S Y+D LK ++F + +W L IIF TG I++F +GYL+ F +L G +L+ K ++ + ++ YN VI K I ++ C +++ L CW++ LF++ C I+G K A + +G+ WD +CF F++LQR +F + FL V D+ F+S
Sbjct: 815 IWWLLEIHIIKIVSCYIILLTLYEVSLLNFVFLVCWAFALPYSQYRPLASSICTVWTCVIIVCKMLYQLKTINPPPF--DCSYVEQSGKYTGDRVSEVKESLLYKIPGDPGNWWGLKKTEDLLGYLRNNLLMLALLAFEVTIYRHQLYFRLRNKLSPPAAPIIFHDITRQHLDMGITYFIKYFINYFFYKFGLETCLLLVVNVIGQRMDFYAMLHAFALIAVMYRRRRKAIAEIWSKYCFFLACMLTFQYFVCIGIPPAACKDYPWSFTTDSNVIKWLYIPDFYKKPDPLFLIYDFMLLLCASMQRQVFEDENKAAVRLIAGDNVEICRD--LDAASFSVHNPVPDFIHCRS-YLDMLKVIMFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGELLLKPIKKILHYWDFLIAYNIFVITMKNILSILACGYIDSLMENN-CWLIQLFSLSC------TIKGYVIKLASSDTCDIPKNEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIRASGSFAS 1328
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000010240.1 (SMESG000010240.1) HSP 1 Score: 2939.83 bits (7620), Expect = 0.000e+0 Identity = 1522/1685 (90.33%), Postives = 1580/1685 (93.77%), Query Frame = 2
Query: 878 EFIRDVNNMVFTATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXXXXXXXXXLRVNLDMLPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGKEIEKIVKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLR-STESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKN-MEKTKSDAIDN 5926
EFIRDVNN+VFTATEKLKSLYTLTQ SIWR WECHFTKFLVILIVYVCIIDVHAMNIILILIIVIGFPFPRLH VMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSLVYLLMLLLFLILKRDLCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQ+QVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHG+NADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLEIMKSIEKQKKSEEKELNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFEEDSEDEDREDGEESSLSMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRSFSSVHSSSHLRVNLDMLPNEYESCC ENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLG+EIEK VKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSE YKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPFIAMIITQFIFIIIDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTD+SVA +HWMEVED+F KIFVLKCWR E +PT RG RRL KYS+G L+L FFF C WGPL +SSFIG TFVK PPIEC+FSI+VG YSPLF F SRENN++ L K TF++MKEC+K P DYL SFE D TQI ID +SD+VW ITPP L+KLK KL SLKINMQA+CER S+DSK+TEK+VR T ++ L +K NLL I +S V + IFPRFLTAYKRTLSEA +L ++ N TYLN++LSMK +N WWE+ EI+ G++YC N P + + LT+FIF+ER+SDN+FGH+FS+YGI+G+YAAY FV HR LR FYS+ISYII EELP+VDRI LL+EIYLVRENK RLEEQLIAKLIFLYRS+ETMIKWT+H KS L N +E+ +D DN
Sbjct: 809 EFIRDVNNVVFTATEKLKSLYTLTQSSIWRFWECHFTKFLVILIVYVCIIDVHAMNIILILIIVIGFPFPRLHTVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSLVYLLMLLLFLILKRDLCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQFQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGQNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLEIMKSIEKQKKSEEKELNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFEEDSEDEDREDGEESSLSMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRSFSSVHSSSHLRVNLDMLPNEYESCCPENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGQEIEKFVKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSELYKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPFIAMIITQFIFIIIDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGILILIFFFFCIWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLEANQVERVSADDADN 2493
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000010240.1 (SMESG000010240.1) HSP 1 Score: 2938.29 bits (7616), Expect = 0.000e+0 Identity = 1522/1685 (90.33%), Postives = 1580/1685 (93.77%), Query Frame = 2
Query: 878 EFIRDVNNMVFTATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXXXXXXXXXLRVNLDMLPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGKEIEKIVKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLR-STESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKN-MEKTKSDAIDN 5926
EFIRDVNN+VFTATEKLKSLYTLTQ SIWR WECHFTKFLVILIVYVCIIDVHAMNIILILIIVIGFPFPRLH VMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSLVYLLMLLLFLILKRDLCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQ+QVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHG+NADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLEIMKSIEKQKKSEEKELNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFEEDSEDEDREDGEESSLSMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRSFSSVHSSSHLRVNLDMLPNEYESCC ENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLG+EIEK VKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSE YKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPFIAMIITQFIFIIIDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTD+SVA +HWMEVED+F KIFVLKCWR E +PT RG RRL KYS+G L+L FFF C WGPL +SSFIG TFVK PPIEC+FSI+VG YSPLF F SRENN++ L K TF++MKEC+K P DYL SFE D TQI ID +SD+VW ITPP L+KLK KL SLKINMQA+CER S+DSK+TEK+VR T ++ L +K NLL I +S V + IFPRFLTAYKRTLSEA +L ++ N TYLN++LSMK +N WWE+ EI+ G++YC N P + + LT+FIF+ER+SDN+FGH+FS+YGI+G+YAAY FV HR LR FYS+ISYII EELP+VDRI LL+EIYLVRENK RLEEQLIAKLIFLYRS+ETMIKWT+H KS L N +E+ +D DN
Sbjct: 835 EFIRDVNNVVFTATEKLKSLYTLTQSSIWRFWECHFTKFLVILIVYVCIIDVHAMNIILILIIVIGFPFPRLHTVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSLVYLLMLLLFLILKRDLCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQFQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGQNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLEIMKSIEKQKKSEEKELNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFEEDSEDEDREDGEESSLSMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRSFSSVHSSSHLRVNLDMLPNEYESCCPENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGQEIEKFVKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSELYKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPFIAMIITQFIFIIIDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGILILIFFFFCIWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLEANQVERVSADDADN 2519
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000010240.1 (SMESG000010240.1) HSP 1 Score: 2924.04 bits (7579), Expect = 0.000e+0 Identity = 1522/1714 (88.80%), Postives = 1580/1714 (92.18%), Query Frame = 2
Query: 878 EFIRDVNNMVFTATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXXXXXXXXXLRVNLDMLPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGKEIEKIVKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLR-STESLKINMQAICERR-----------------------------SSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKN-MEKTKSDAIDN 5926
EFIRDVNN+VFTATEKLKSLYTLTQ SIWR WECHFTKFLVILIVYVCIIDVHAMNIILILIIVIGFPFPRLH VMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSLVYLLMLLLFLILKRDLCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQ+QVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHG+NADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLEIMKSIEKQKKSEEKELNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFEEDSEDEDREDGEESSLSMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRSFSSVHSSSHLRVNLDMLPNEYESCC ENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLG+EIEK VKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSE YKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPFIAMIITQFIFIIIDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTD+SVA +HWMEVED+F KIFVLKCWR E +PT RG RRL KYS+G L+L FFF C WGPL +SSFIG TFVK PPIEC+FSI+VG YSPLF F SRENN++ L K TF++MKEC+K P DYL SFE D TQI ID +SD+VW ITPP L+KLK KL SLKINMQA+CER S+DSK+TEK+VR T ++ L +K NLL I +S V + IFPRFLTAYKRTLSEA +L ++ N TYLN++LSMK +N WWE+ EI+ G++YC N P + + LT+FIF+ER+SDN+FGH+FS+YGI+G+YAAY FV HR LR FYS+ISYII EELP+VDRI LL+EIYLVRENK RLEEQLIAKLIFLYRS+ETMIKWT+H KS L N +E+ +D DN
Sbjct: 809 EFIRDVNNVVFTATEKLKSLYTLTQSSIWRFWECHFTKFLVILIVYVCIIDVHAMNIILILIIVIGFPFPRLHTVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSLVYLLMLLLFLILKRDLCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPKLRQWLYLPNYKVSPVPGKILADFVQYIFVVLQFQVFQMEKRKKSDSHKLVKQRLLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWEIRGIHGQNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLEIMKSIEKQKKSEEKELNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFEEDSEDEDREDGEESSLSMVGSNTISLESNLPTSSVGKDISVSTDSQRHLEDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDDLSLIGTLNPLQLINAVVKEGPKQAIRQYKRSFSSVHSSSHLRVNLDMLPNEYESCCPENPDVSPSEEVRENSFRSSTVHDNSTNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNGNQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFIEIDEKLGQEIEKFVKDGRKSVSEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSELYKDIKISNEEEVNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPFIAMIITQFIFIIIDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDSSVAFYHWMEVEDIFSKIFVLKCWRYGETIWPTERGRNRRLVVKYSLGILILIFFFFCIWGPLMISSFIGITFVKYPPIECSFSINVGDYSPLFVFSSRENNMRPLTKKTFEEMKECHKFHLPSKDYLQSFEPDDATQIIIDYASDNVWLITPPGLKKLKEKLSIPRASLKINMQAVCERYLLNSLVIFENHLYSPLQINCGSPISLAQPSTDSKSTEKIVRFTQSRFLTNPEKANLLHLINTKFNSTNVYLPTIFPRFLTAYKRTLSEANSLHQNQNNTYLNISLSMKTDNAMMWWEVNEIIQGQSYCPNPDSPSKKYLFLTIFIFNERISDNIFGHIFSSYGILGIYAAYFFVVHRFLRTFYSNISYIIPAEELPNVDRIHKLLHEIYLVRENKKLRLEEQLIAKLIFLYRSSETMIKWTQHWKSTLEANQVERVSADDADN 2522
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000051188.1 (SMESG000051188.1) HSP 1 Score: 2113.96 bits (5476), Expect = 0.000e+0 Identity = 1131/1763 (64.15%), Postives = 1336/1763 (75.78%), Query Frame = 2
Query: 872 LSEFIRDVNNMVFTATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPK-LRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQR--LLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWE-----IRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLE-----------------SNLPTSSVGKDISVSTDSQRHL------EDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDD---LSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXX-----------------XXXXXXXLRVNLDMLPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNS-TNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNG--------NQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFI-EIDEKLGKE--IEKIVKDGRKSV--SEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEE--VNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKNMEKTKSDAIDNVNNDKEITMSS 5959
+S FI DVN+ EKLK + + +WR +ECHFTK +V IV CI + +A NI+LI+++VIGFPF +LH ++VT F + V++KMIYQ+K FNW TNCS Y N SM+ IDNAKW+GLEK+ NFQ HI KWTA+LV CA+WH+V+YHQ QFYK KP+T +IF E + S ++ +L K+ +NF F K+GLELSFI TV+V+CLR+DVYSLVYL++LL+FL +R +C+ +WLPYM+FLG+LLP++Y ICVGLPPGLC +YPL + + L++WL+LP+Y+ P KI+ADF Q++FV LQY+VF +E +++ + R L K+I KDF+S K SYVDYLKH +FYWSYWL+LAI+FTTGVFWITLF LGY+++AFIYLWMGQ +++ K+ +LI S NVI+YYNF VIL+KC QL+GC +M+ + +K CWM+ LF +QCINPMSW+ + +HG CSSV SGLHWDV CF FIILQR IF F V LDL+VQN+F+SRGAYLIN ++M SI +QK EE L++I+ KI KI QRQAQHGKPELNEHYLV+RSGD YLFE DS+++D + + S T++ E +L + + ++V T R+L S R + +N+ K I I +K+ ++ + S +DD L + T+NPL LIN +++GP+ AIR++KR+ S S S L LP+ Y + P SE E+SF S+ + DN TN L L++ E+E +Y + N + S + +SN + ES W FK I + FI +T +L VL N WT+EY R R L+ EK+LVK VLS E+D ++ E + +IV DG + S+++EE K+ FRRSRS+FF L IS G VAIIYSEF CYFLLI+NH+LSGNL SLPYP +VF W MLSVPRPSKNFWI LITYTE+VIV KYI QFN I N R+DPL +PLI+GIEKS+ YAI+D+IQLLF+FLHR YLK NGLWRDH+EF +D++I ++E+ N I+ +S+ + NPI ++++FY KMTN K NK+VDVY MFLCEF A LIII GY SFGPGTDS +A DFIKTNK PVPFI MIITQF+FIIIDRALFLRKQVKGKF+FQIFHV+LIHAWLFFALP+ITK+KFNSQ PQLLYF+KC+YFALS+YQM+SGYP+RILGNFLTR++NY NL FK YM +PFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKNMEKTKSDAIDNVNNDKEITMSS
Sbjct: 835 VSAFIEDVNSAFQIIIEKLKQFFEVIYAKVWRFFECHFTKIVVFCIVSACINEENACNIVLIILVVIGFPFHKLHTILVTGSFFWCSLTVLMKMIYQLKTVNKFNWSTNCSLYTTNFNKSMDQIDNAKWIGLEKVNNFQDHIWKWTAVLVVCALWHVVKYHQRQFYKCPNATKPETGIIFPETTVQSIDDSLINLFKFCINFAFYKLGLELSFIVTVIVACLRVDVYSLVYLILLLIFLCTQRKICSKIWLPYMLFLGVLLPIEYAICVGLPPGLCQKYPLTSLKENLQRWLFLPSYEYPPSAKKIMADFFQFVFVALQYRVFIIENSLTVNNYGGGRNRPILCNELPKTIDKDFVSTKDSYVDYLKHAIFYWSYWLSLAIVFTTGVFWITLFCLGYMILAFIYLWMGQNIMLRKRSNLIASWNVIIYYNFFVILSKCTLQLIGCAYMDWMISKRFCWMIPLFGVQCINPMSWDRNMLAVNRMHG----DPCSSVKSGLHWDVTCFLFIILQRKIFMTKNFCHVVLDLNVQNRFASRGAYLINRKMMASIREQKLKEECVLDKIKMKIDKIIQRQAQHGKPELNEHYLVVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSEHDELSSLPDAYNT----PPPAHISETTTEDSFHSAAIQDNQLTNDQAQLTLDLYSANTPESE-KYLNPLIYRDTNISSNSVPELISNDETDKKIEKSAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHNFVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFN--ETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKNMEKTKSDAIDNVNNDKEITMSS 2586
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Match: SMESG000051188.1 (SMESG000051188.1) HSP 1 Score: 2110.11 bits (5466), Expect = 0.000e+0 Identity = 1132/1778 (63.67%), Postives = 1338/1778 (75.25%), Query Frame = 2
Query: 872 LSEFIRDVNNMVFTATEKLKSLYTLTQPSIWRLWECHFTKFLVILIVYVCIIDVHAMNXXXXXXXXXGFPFPRLHMVMVTALFVCSASIVILKMIYQIKIFQTFNWLTNCSQYGNFANSSMEIIDNAKWLGLEKLENFQLHILKWTAILVGCAVWHIVRYHQMQFYKLNLDQKPKTSVIFQEVEIHSSIENFCDLLKYSLNFGFQKIGLELSFICTVVVSCLRIDVYSXXXXXXXXXXXXXXXXXCNVLWLPYMIFLGILLPVQYVICVGLPPGLCIEYPLNVIPK-LRQWLYLPNYKVSPVPGKILADFVQYIFVVLQYQVFQMEKRKKSDSHKLVKQR--LLEGFQKSIHKDFISKKSSYVDYLKHVVFYWSYWLTLAIIFTTGVFWITLFGLGYLLIAFIYLWMGQIVLIGKQKSLIRSCNVILYYNFLVILTKCIFQLMGCVFMNLLKTKGLCWMVSLFAIQCINPMSWE-----IRGIHGKNADKQCSSVASGLHWDVVCFFFIILQRMIFTADPFLLVKLDLHVQNKFSSRGAYLINLXXXXXXXXXXXXXXXXLNRIERKIKKIEQRQAQHGKPELNEHYLVMRSGDYYLFXXXXXXXXXXXXXXXXXXMVGSNTISLES-----------------NLPTSSVGKDISVSTDSQRHL------EDDSNSLDRHTNENKRKSIGIILEKNEQEDEKSGDDD---LSLIGTLNPLQLINAVVKEGPKQAIRQYKRXXXX----------------XXXXXXLRVNLDM----------------LPNEYESCCIENPDVSPSEEVRENSFRSSTVHDNS-TNFPQYHNLHLHTPIPSENETRYQSSHNTAIVNTGTESSVDPVSNG--------NQRLESSWENFKNVIKLCVCFIGSTMASLTVLFNEWTREYYRNIRKLEEEKKLVKSHVLSTFI-EIDEKLGKE--IEKIVKDGRKSV--SEDKEEKNKQDVFRRSRSKFFSLLISFGKVAIIYSEFGCYFLLIMNHLLSGNLLSLPYPFLVFFWGMLSVPRPSKNFWIVLITYTELVIVFKYICQFNLIKLNVLPVPEHRIDPLALPLILGIEKSRTYAIIDVIQLLFLFLHRSYLKGNGLWRDHSEFYKDIKISNEEE--VNHIQPLKPQSAMRTGIKFRNPIKQLKKFYGKMTNRKLNKRVDVYAIMFLCEFTAMLIIILGYFSFGPGTDSGGHAIDFIKTNKTPVPXXXXXXXXXXXXXXDRALFLRKQVKGKFVFQIFHVILIHAWLFFALPYITKRKFNSQFPPQLLYFIKCVYFALSSYQMRSGYPMRILGNFLTRNYNYGNLIFFKIYMGIPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKNMEKTKSDAIDNVNNDKEITMSS 5959
+S FI DVN+ EKLK + + +WR +ECHFTK +V IV CI + +A NI+LI+++VIGFPF +LH ++VT F + V++KMIYQ+K FNW TNCS Y N SM+ IDNAKW+GLEK+ NFQ HI KWTA+LV CA+WH+V+YHQ QFYK KP+T +IF E + S ++ +L K+ +NF F K+GLELSFI TV+V+CLR+DVYSLVYL++LL+FL +R +C+ +WLPYM+FLG+LLP++Y ICVGLPPGLC +YPL + + L++WL+LP+Y+ P KI+ADF Q++FV LQY+VF +E +++ + R L K+I KDF+S K SYVDYLKH +FYWSYWL+LAI+FTTGVFWITLF LGY+++AFIYLWMGQ +++ K+ +LI S NVI+YYNF VIL+KC QL+GC +M+ + +K CWM+ LF +QCINPMSW+ + +HG CSSV SGLHWDV CF FIILQR IF F V LDL+VQN+F+SRGAYLIN ++M SI +QK EE L++I+ KI KI QRQAQHGKPELNEHYLV+RSGD YLFE DS+++D + + S T++ E +L + + ++V T R+L S R + +N+ K I I +K+ ++ + S +DD L + T+NPL LIN +++GP+ AIR++KR+ S S V LD+ LP+ Y + P SE E+SF S+ + DN TN L L++ E+E +Y + N + S + +SN + ES W FK I + FI +T +L VL N WT+EY R R L+ EK+LVK VLS E+D ++ E + +IV DG + S+++EE K+ FRRSRS+FF L IS G VAIIYSEF CYFLLI+NH+LSGNL SLPYP +VF W MLSVPRPSKNFWI LITYTE+VIV KYI QFN I N R+DPL +PLI+GIEKS+ YAI+D+IQLLF+FLHR YLK NGLWRDH+EF +D++I ++E+ N I+ +S+ + NPI ++++FY KMTN K NK+VDVY MFLCEF A LIII GY SFGPGTDS +A DFIKTNK PVPFI MIITQF+FIIIDRALFLRKQVKGKF+FQIFHV+LIHAWLFFALP+ITK+KFNSQ PQLLYF+KC+YFALS+YQM+SGYP+RILGNFLTR++NY NL FK YM +PFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKNMEKTKSDAIDNVNNDKEITMSS
Sbjct: 839 VSAFIEDVNSAFQIIIEKLKQFFEVIYAKVWRFFECHFTKIVVFCIVSACINEENACNIVLIILVVIGFPFHKLHTILVTGSFFWCSLTVLMKMIYQLKTVNKFNWSTNCSLYTTNFNKSMDQIDNAKWIGLEKVNNFQDHIWKWTAVLVVCALWHVVKYHQRQFYKCPNATKPETGIIFPETTVQSIDDSLINLFKFCINFAFYKLGLELSFIVTVIVACLRVDVYSLVYLILLLIFLCTQRKICSKIWLPYMLFLGVLLPIEYAICVGLPPGLCQKYPLTSLKENLQRWLFLPSYEYPPSAKKIMADFFQFVFVALQYRVFIIENSLTVNNYGGGRNRPILCNELPKTIDKDFVSTKDSYVDYLKHAIFYWSYWLSLAIVFTTGVFWITLFCLGYMILAFIYLWMGQNIMLRKRSNLIASWNVIIYYNFFVILSKCTLQLIGCAYMDWMISKRFCWMIPLFGVQCINPMSWDRNMLAVNRMHGD----PCSSVKSGLHWDVTCFLFIILQRKIFMTKNFCHVVLDLNVQNRFASRGAYLINRKMMASIREQKLKEECVLDKIKMKIDKIIQRQAQHGKPELNEHYLVVRSGDKYLFEGDSDEDDEDVEGDIDESCSKKMTVTSEDTFDKNTSNNQNKKCSVDSLDSQGLFNAVNVVTSHSRNLLKPISESRCSTESSRKSLDNQNKIIKEINKKDAKDSDSSEEDDANPLQVQNTINPLHLINRAMEQGPRSAIREFKRTQSECKENLPSNRRSSVHLGSRLESMSSVGLDIHGSRQTRRSEHDELSSLPDAYNT----PPPAHISETTTEDSFHSAAIQDNQLTNDQAQLTLDLYSANTPESE-KYLNPLIYRDTNISSNSVPELISNDETDKKIEKSAHPESCWSKFKASILIVYYFIQTTTDNLIVLINTWTKEYRRIRRTLDNEKRLVKLKVLSKISNEVDGRIELEAIVVEIVGDGSHNFVNSKNQEEYLKEQEFRRSRSRFFLLAISLGNVAIIYSEFVCYFLLILNHMLSGNLFSLPYPLMVFLWAMLSVPRPSKNFWIALITYTEIVIVIKYIFQFNFISFN--ETTNDRVDPLWIPLIIGIEKSKNYAILDLIQLLFIFLHRGYLKNNGLWRDHTEFAQDLEIVDKEQDGRNKIKSSYEESSPTSNKWSCNPIYKMRRFYSKMTNPKFNKKVDVYVFMFLCEFIAFLIIIFGYVSFGPGTDSADNAFDFIKTNKIPVPFITMIITQFVFIIIDRALFLRKQVKGKFIFQIFHVLLIHAWLFFALPHITKKKFNSQIAPQLLYFVKCIYFALSAYQMKSGYPLRILGNFLTRDFNYINLFLFKGYMIVPFLYELRNVMDWMWTDTSVALFHWMEVEDVFCKIFVLKCWRRSELEYPTVRGNTRRLASKYSVGGLLLAFFFICFWGPLTLSSFIGTTFVKNPPIECTFSISVGGYSPLFYFISRENNLKSLPKDTFDKMKECYKNFSPPTDYLMSFEAGDVTQISIDGSSDDVWTITPPSLEKLKVKLRSTESLKINMQAICERRSSDSKTTEKMVRHTNTKQLDENDKKNLLKAIEANQSSYVVQIDAIFPRFLTAYKRTLSEATALLKDHNQTYLNLTLSMKKENEARWWEIQEIVAGETYCSNEKIPKQSHSNLTVFIFSERVSDNLFGHLFSNYGIIGMYAAYIFVAHRVLRAFYSDISYIIRCEELPHVDRILNLLNEIYLVRENKMFRLEEQLIAKLIFLYRSTETMIKWTRHNKSILSKNMEKTKSDAIDNVNNDKEITMSS 2605 The following BLAST results are available for this feature:
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 4
BLAST of Piezo-type mechanosensitive ion channel component vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Piezo-type mechanosensitive ion channel component vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30016398 ID=SMED30016398|Name=Piezo-type mechanosensitive ion channel component|organism=Schmidtea mediterranea sexual|type=transcript|length=6227bpback to top protein sequence of SMED30016398-orf-1 >SMED30016398-orf-1 ID=SMED30016398-orf-1|Name=SMED30016398-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1731bp MTATVRNKNALLAVQLQVTLRPTSIRVSGLLTFYLSEFIRDVNNMVFTATback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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