beta-secretase 1

Overview
Namebeta-secretase 1
Smed IDSMED30016267
Length (bp)1714
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of beta-secretase 1 (SMED30016267) t-SNE clustered cells

Violin plots show distribution of expression levels for beta-secretase 1 (SMED30016267) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of beta-secretase 1 (SMED30016267) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for beta-secretase 1 (SMED30016267) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30016267

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30016267h1SMcG0002395 Contig1168GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
dorsal ventral margin of the whole animalSMED30016267h1SMcG0002395 Contig1168GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30016267h1SMcG0002395 Contig1168GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
Category 3 cellSMED30016267h1SMcG0002395 dd_Smed_v4_4132_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of beta-secretase 1 vs. Ensembl Human
Match: BACE1 (beta-secretase 1 [Source:HGNC Symbol;Acc:HGNC:933])

HSP 1 Score: 245.743 bits (626), Expect = 5.821e-74
Identity = 140/382 (36.65%), Postives = 210/382 (54.97%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N++E   +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   66 NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 423
[Close]
BLAST of beta-secretase 1 vs. Ensembl Human
Match: BACE1 (beta-secretase 1 [Source:HGNC Symbol;Acc:HGNC:933])

HSP 1 Score: 219.935 bits (559), Expect = 1.704e-64
Identity = 132/382 (34.55%), Postives = 195/382 (51.05%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+                           LCG     N++E   +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   66 NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIAR---------------------------LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGTT--PWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 398
[Close]
BLAST of beta-secretase 1 vs. Ensembl Human
Match: BACE1 (beta-secretase 1 [Source:HGNC Symbol;Acc:HGNC:933])

HSP 1 Score: 206.838 bits (525), Expect = 1.063e-59
Identity = 126/382 (32.98%), Postives = 193/382 (50.52%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N++E   +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKE  +             FP+                          FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   66 NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKETEK-------------FPD-------------------------GFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 389
[Close]
BLAST of beta-secretase 1 vs. Ensembl Human
Match: BACE2 (beta-secretase 2 [Source:HGNC Symbol;Acc:HGNC:934])

HSP 1 Score: 205.682 bits (522), Expect = 1.112e-58
Identity = 131/388 (33.76%), Postives = 200/388 (51.55%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTN-GFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLHVATVSRSRI 1410
            +L+G S  GYY+ + IG+PPQK  +++DTGSSN AVAG+P  ++  YF ++ SSTY      V V Y  G W G    D+ T          K    S  +N+ + F    ES  FF     + GILGLAY  LA+P++ +   T FD +V +  +PN+FS+ +CG     +   TN G  + GG   SLY   +    I+ +W+Y+I I ++ I  + + L  C+EYN DK+I+D+GT     P  +F ++V ++      A         FW    + C  +NS   P +YFP+I I     ++S S  + +  Q YIQ     +   G    CY+FG   S +  ++G + +EGFY +F++   +VG A S C   +A  + S I
Sbjct:   83 NLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIP--------KGFNTSFLVNIATIF----ESENFFLPGIKWNGILGLAYATLAKPSSSLE--TFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNL-DCREYNADKAIVDSGTTLLRLPQKVFDAVVEAV----ARASLIPEFSDGFWTGSQLAC-WTNS-ETPWSYFPKISIYLRDENSSRSFRITILPQLYIQ----PMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPC-AEIAGAAVSEI 444
[Close]
BLAST of beta-secretase 1 vs. Ensembl Human
Match: BACE1 (beta-secretase 1 [Source:HGNC Symbol;Acc:HGNC:933])

HSP 1 Score: 187.578 bits (475), Expect = 3.317e-53
Identity = 118/345 (34.20%), Postives = 179/345 (51.88%), Query Frame = 1 
Query:  370 PQQFLSNYFK--SQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            P  +L  +F   S  SSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N++E   +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:    3 PFIYLQAHFTLCSGWSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMD-CKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGTT--PWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 323
[Close]
BLAST of beta-secretase 1 vs. Ensembl Celegans
Match: asp-4 (ASpartyl Protease [Source:UniProtKB/TrEMBL;Acc:Q21966])

HSP 1 Score: 72.7886 bits (177), Expect = 1.943e-13
Identity = 97/388 (25.00%), Postives = 156/388 (40.21%), Query Frame = 1 
Query:  244 IETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQF------LSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLP-NMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGV---SKSGT--ILGDSFLEGFYFLFNKELSKVGIAQSK 1371
            I+  L+   +  Y+ T+ IG+P Q F ++ DTGSSN  +      F      L + + S+ SSTY +    + + Y +G   G  S D     GV   D    +  S            +   TF      F GILG+AYP +A    ++    +F+ +  +  +P N+FS  L   NRN       G    GG +   Y  P+  + + RK +++  + ++  S      + C      ++I DTGT+    P     +     I N   A        P      +I      P  P        + FVI      E +L  + Y+  V     S G +  C     G+    + G   ILGD F+  +Y +F+ + ++VG AQ+K
Sbjct:   82 IDELLRNYMDAQYFGTISIGTPAQNFTVIFDTGSSNLWIPSKKCPFYDIACMLHHRYDSKSSSTYKEDGRKMAIQYGTGSMKGFISKDSVCVAGVCAEDQPFAEATS------------EPGITFVA--AKFDGILGMAYPEIA----VLGVQPVFNTLFEQKKVPSNLFSFWL---NRNPDS-EIGGEITFGGIDSRRYVEPITYVPVTRKGYWQFKMDKVVGSGVLGCSNGC------QAIADTGTSLIAGPKAQIEA-----IQNFIGA-------EPLIKGEYMIS-CDKVPTLPP-------VSFVIG---GQEFSLKGEDYVLKV-----SQGGKTICLSGFMGIDLPERVGELWILGDVFIGRYYSVFDFDQNRVGFAQAK 413
[Close]
BLAST of beta-secretase 1 vs. Ensembl Celegans
Match: asp-1 (ASpartyl Protease; Aspartic protease 1 [Source:UniProtKB/TrEMBL;Acc:G5EEI4])

HSP 1 Score: 56.6102 bits (135), Expect = 2.614e-8
Identity = 89/374 (23.80%), Postives = 144/374 (38.50%), Query Frame = 1 
Query:  280 YYMTVGIGSPPQKFNLVIDTGSSNTAV--AGSPQQFLSNY---------FKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQS 1368
            Y   + +G+PPQ   +V+DTGSSN  V  A    Q  + Y         F +  S+T+V       + Y SG  NG    D+  F G+      ++Q +    ++   FG       + P +    GILGL +P LA    +     L   +  K     +F+V L   N   +Q T  G    G  +       +  + +  K +++  +   ++        +  E  +D+ I DTGT+    PN I    VS+I+   K A F        W         S     P   F     +F +    S+E  L  Q         + S G+       GFG S    ILGD+F+  +  +++    ++G A +
Sbjct:   68 YLGNITLGTPPQPATVVLDTGSSNLWVIDAACKTQACNGYPDSGYTKQKFDTTKSTTFVKETRKFSIQYGSGSCNGYLGKDVLNFGGLTV----QSQEFGVSTHLADVFG-------YQPVD----GILGLGWPALAVDQVVPPMQNL---IAQKQLDAPLFTVWL-DRNLQIAQGTPGGLITYGAIDTVNCAKQVTYVPLSAKTYWQFPLDAFAV-------GTYSETKKDQVISDTGTSWLGAPNTI----VSAIVKQTK-AVFD-------WSTELYTVDCSTMKTQPDLIFTIGGAQFPVK---SVEYVLDLQLGGGKCALAVFSMGSG------GFGPSW---ILGDTFIRQYCNVYDIGNGQIGFATA 391
[Close]
BLAST of beta-secretase 1 vs. Ensembl Celegans
Match: asp-1 (ASpartyl Protease; Aspartic protease 1 [Source:UniProtKB/TrEMBL;Acc:G5EEI4])

HSP 1 Score: 56.6102 bits (135), Expect = 2.614e-8
Identity = 89/374 (23.80%), Postives = 144/374 (38.50%), Query Frame = 1 
Query:  280 YYMTVGIGSPPQKFNLVIDTGSSNTAV--AGSPQQFLSNY---------FKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQS 1368
            Y   + +G+PPQ   +V+DTGSSN  V  A    Q  + Y         F +  S+T+V       + Y SG  NG    D+  F G+      ++Q +    ++   FG       + P +    GILGL +P LA    +     L   +  K     +F+V L   N   +Q T  G    G  +       +  + +  K +++  +   ++        +  E  +D+ I DTGT+    PN I    VS+I+   K A F        W         S     P   F     +F +    S+E  L  Q         + S G+       GFG S    ILGD+F+  +  +++    ++G A +
Sbjct:   68 YLGNITLGTPPQPATVVLDTGSSNLWVIDAACKTQACNGYPDSGYTKQKFDTTKSTTFVKETRKFSIQYGSGSCNGYLGKDVLNFGGLTV----QSQEFGVSTHLADVFG-------YQPVD----GILGLGWPALAVDQVVPPMQNL---IAQKQLDAPLFTVWL-DRNLQIAQGTPGGLITYGAIDTVNCAKQVTYVPLSAKTYWQFPLDAFAV-------GTYSETKKDQVISDTGTSWLGAPNTI----VSAIVKQTK-AVFD-------WSTELYTVDCSTMKTQPDLIFTIGGAQFPVK---SVEYVLDLQLGGGKCALAVFSMGSG------GFGPSW---ILGDTFIRQYCNVYDIGNGQIGFATA 391
[Close]
BLAST of beta-secretase 1 vs. Ensembl Celegans
Match: asp-12 (ASpartyl Protease [Source:UniProtKB/TrEMBL;Acc:O01531])

HSP 1 Score: 54.299 bits (129), Expect = 1.260e-7
Identity = 50/202 (24.75%), Postives = 88/202 (43.56%), Query Frame = 1 
Query:   64 MIKQIQIYIFIFGILYSSGEIHSPLFRMIPPQNIYPEESDFSLKGFNVAEKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLS---NYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRS-NFGLIKESTTFFPKNGNFQGILGLAYPVLA 657
            M   +  ++ I G+  ++   H  ++R  P   +       +      A +  +  +      ++    +  Y   + IG+PPQ+F +V+DTGS+N  V GS         + F S  S+T+  +  S  + Y+SG   G+   D   F G +           +++ V S  FG+    ++ F KN   +GILGLA+  LA
Sbjct:    1 MKTTLLAFVAILGMCSATVVQHKLIYRESPKMQMMRRGEWGAYVQHKAALRDANPAVFASAPQNVNDFGDVEYLGNITIGTPPQQFIVVLDTGSANLWVPGSNCDGTCKGKSEFDSSKSTTFKKNGQSWQIQYESGSAKGIMGVDTVAFGGAS----------EQQLLVPSTTFGIASHISSNF-KNDAAEGILGLAFTSLA 191
[Close]
BLAST of beta-secretase 1 vs. Ensembl Celegans
Match: asp-12 (ASpartyl Protease [Source:UniProtKB/TrEMBL;Acc:O01531])

HSP 1 Score: 54.299 bits (129), Expect = 1.260e-7
Identity = 50/202 (24.75%), Postives = 88/202 (43.56%), Query Frame = 1 
Query:   64 MIKQIQIYIFIFGILYSSGEIHSPLFRMIPPQNIYPEESDFSLKGFNVAEKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLS---NYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRS-NFGLIKESTTFFPKNGNFQGILGLAYPVLA 657
            M   +  ++ I G+  ++   H  ++R  P   +       +      A +  +  +      ++    +  Y   + IG+PPQ+F +V+DTGS+N  V GS         + F S  S+T+  +  S  + Y+SG   G+   D   F G +           +++ V S  FG+    ++ F KN   +GILGLA+  LA
Sbjct:    1 MKTTLLAFVAILGMCSATVVQHKLIYRESPKMQMMRRGEWGAYVQHKAALRDANPAVFASAPQNVNDFGDVEYLGNITIGTPPQQFIVVLDTGSANLWVPGSNCDGTCKGKSEFDSSKSTTFKKNGQSWQIQYESGSAKGIMGVDTVAFGGAS----------EQQLLVPSTTFGIASHISSNF-KNDAAEGILGLAFTSLA 191
[Close]
BLAST of beta-secretase 1 vs. Ensembl Fly
Match: Bace (gene:FBgn0032049 transcript:FBtr0343427)

HSP 1 Score: 73.9442 bits (180), Expect = 8.413e-14
Identity = 80/300 (26.67%), Postives = 128/300 (42.67%), Query Frame = 1 
Query:  115 SGEIHS-PLFR----MIPPQNIYPEESDFSLKGFNVAEKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAV----AGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPA------NLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTA 969
            S E+H  P+ +    +   QN+  E+S    K    + +SVD       E  L    N  YY  + IG+P Q F ++ D+GSSN  V      S      N + S  SSTYV +  S  + Y +G   G  S+D     G++     ++Q +++  N        +  T F   + NF GILG+AY  LA         N++ +  L D+ V  + L              +   T  G  I GG + SLY+  L  + I  + +++  ++  SI    +    C +    ++I DTGT+
Sbjct:   16 SAELHRVPILKEQNFVKTRQNVLAEKSYLRTKYQLPSLRSVD-------EEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLSTDTVDVNGLSI----QSQTFAESTN--------EPGTNF--NDANFDGILGMAYESLAVDGVAPPFYNMVSQG-LVDNSVFSFYLA------------RDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYSL----CDDC---QAIADTGTS 274
[Close]
BLAST of beta-secretase 1 vs. Ensembl Fly
Match: Bace (gene:FBgn0032049 transcript:FBtr0079701)

HSP 1 Score: 73.9442 bits (180), Expect = 8.413e-14
Identity = 80/300 (26.67%), Postives = 128/300 (42.67%), Query Frame = 1 
Query:  115 SGEIHS-PLFR----MIPPQNIYPEESDFSLKGFNVAEKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAV----AGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPA------NLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTA 969
            S E+H  P+ +    +   QN+  E+S    K    + +SVD       E  L    N  YY  + IG+P Q F ++ D+GSSN  V      S      N + S  SSTYV +  S  + Y +G   G  S+D     G++     ++Q +++  N        +  T F   + NF GILG+AY  LA         N++ +  L D+ V  + L              +   T  G  I GG + SLY+  L  + I  + +++  ++  SI    +    C +    ++I DTGT+
Sbjct:   16 SAELHRVPILKEQNFVKTRQNVLAEKSYLRTKYQLPSLRSVD-------EEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLSTDTVDVNGLSI----QSQTFAESTN--------EPGTNF--NDANFDGILGMAYESLAVDGVAPPFYNMVSQG-LVDNSVFSFYLA------------RDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYSL----CDDC---QAIADTGTS 274
[Close]
BLAST of beta-secretase 1 vs. Ensembl Fly
Match: CG17134 (gene:FBgn0032304 transcript:FBtr0080140)

HSP 1 Score: 72.0182 bits (175), Expect = 3.718e-13
Identity = 69/250 (27.60%), Postives = 112/250 (44.80%), Query Frame = 1 
Query:  271 NYGYYMTVGIGSPPQKFNLVIDTGSSNTAV--AGSPQQFLS----NYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPA------NLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFP 984
            N  YY  + IG+P Q+FN++ DTGS+N  V  A  P    +    N + S  SSTYV +     + Y +G  +G  S+DI T  G++     + Q + +         L +  TTF   +  F GILGLA+  +A         N+I +  L D+ V+ + L    + V  G              I GG + SLY   L  + +    +++  ++ I  +N  ++ + C      ++I DTGT+    P
Sbjct:   73 NNEYYGVIAIGTPEQRFNILFDTGSANLWVPSASCPASNTACQRHNKYDSSASSTYVANGEEFAIEYGTGSLSGFLSNDIVTIAGISI----QNQTFGE--------ALSEPGTTFV--DAPFAGILGLAFSAIAVDGVTPPFDNMISQG-LLDEPVISFYLKRQGTAVRGGE------------LILGGIDSSLYRGSLTYVPVSVPAYWQFKVNTIK-TNGTLLCNGC------QAIADTGTSLIAVP 288
[Close]
BLAST of beta-secretase 1 vs. Ensembl Fly
Match: cathD (gene:FBgn0029093 transcript:FBtr0088898)

HSP 1 Score: 63.929 bits (154), Expect = 1.335e-10
Identity = 66/249 (26.51%), Postives = 104/249 (41.77%), Query Frame = 1 
Query:  265 ISNY---GYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQ------FLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLA-----QPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTA 969
            +SNY    YY  + IGSPPQ F +V DTGSSN  V             + N + +  S TY  +     + Y SG  +G  S+D  +  G+      K Q +++ +   S  GL+  +         F GILGL Y  ++      P   +++  L    V  + L           NR+ + P   G  I GG + + Y      + + RK +++I +   SI +  +    C      + I DTGT+
Sbjct:   65 LSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDI----KDQTFAEAL---SEPGLVFVAA-------KFDGILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYL-----------NRDPASP-EGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKMDAASIGDLQLCKGGC------QVIADTGTS 281
[Close]
BLAST of beta-secretase 1 vs. Ensembl Fly
Match: cathD (gene:FBgn0029093 transcript:FBtr0452079)

HSP 1 Score: 63.929 bits (154), Expect = 1.335e-10
Identity = 66/249 (26.51%), Postives = 104/249 (41.77%), Query Frame = 1 
Query:  265 ISNY---GYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQ------FLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLA-----QPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTA 969
            +SNY    YY  + IGSPPQ F +V DTGSSN  V             + N + +  S TY  +     + Y SG  +G  S+D  +  G+      K Q +++ +   S  GL+  +         F GILGL Y  ++      P   +++  L    V  + L           NR+ + P   G  I GG + + Y      + + RK +++I +   SI +  +    C      + I DTGT+
Sbjct:   65 LSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDI----KDQTFAEAL---SEPGLVFVAA-------KFDGILGLGYNSISVDKVKPPFYAMYEQGLISAPVFSFYL-----------NRDPASP-EGGEIIFGGSDPNHYTGEFTYLPVTRKAYWQIKMDAASIGDLQLCKGGC------QVIADTGTS 281
[Close]
BLAST of beta-secretase 1 vs. Ensembl Zebrafish
Match: bace2 (beta-secretase 2 [Source:ZFIN;Acc:ZDB-GENE-041010-68])

HSP 1 Score: 159.844 bits (403), Expect = 2.053e-43
Identity = 101/308 (32.79%), Postives = 161/308 (52.27%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQP--TTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS 1170
            +LKG S  GYYM + IG+P Q  N+++DTGSSN AVA +   ++++YF   LSSTY   + +V V Y  G+W G   +D+ T            +  S  I +  N   I  S  FF    N+QGILGLAYP+LA+P   +     F+ VV + G+P++FS+ +CG     S       G  I GG   +L+  P+    +  +W+Y++ + ++ + ++ + L  CKEYN DK+I+D+GT     P  +F ++V +I+       F     + F+D   + C +      P  +FP++ I     +TS
Sbjct:   71 NLKGDSGRGYYMQMIIGTPGQTLNILVDTGSSNFAVAAAAHPYITHYFNRALSSTYQSTERAVAVKYTQGEWEGELGTDLITIP----------EGPSGAITI--NIAAILTSEGFFLPGINWQGILGLAYPLLARPDPSVEP--FFNSVVRQTGIPDVFSLQMCGAGVPASTTGDPAGGSLIMGGVEPTLHRGPIWYTPVLEEWYYQVEVLKLEVGDQNLNL-DCKEYNSDKAIVDSGTTLLRLPANVFTAVVDTIMQTSLIDDFS----AGFFDGTKLACWMRG--ESPWRFFPKVSIYLRGTNTS 357
[Close]
BLAST of beta-secretase 1 vs. Ensembl Zebrafish
Match: bace1 (beta-secretase 1 [Source:ZFIN;Acc:ZDB-GENE-040426-1835])

HSP 1 Score: 110.538 bits (275), Expect = 3.048e-27
Identity = 59/171 (34.50%), Postives = 94/171 (54.97%), Query Frame = 1 
Query:  235 ITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLC 747
            I +I+ +L+G S  GYY+ + +GSP Q+ N+++DTGSSN AV  +   FL  Y+   LSS+Y D    V VPY  G+W G   +D+ +                  +++R+N   I +S  FF    N++GILGLAY  +A+P   +     FD ++ +  + ++FS+ LC
Sbjct:   66 INMID-NLRGKSGQGYYIEMAVGSPAQRLNILVDTGSSNFAVGAAAHPFLHRYYHRSLSSSYRDLGRGVYVPYTQGRWEGELGTDVVSVP------------CGPNVSLRANIAAITQSDRFFINGSNWEGILGLAYAEIARPDETLEP--FFDSLLRQSTVADVFSLPLC 221
[Close]
BLAST of beta-secretase 1 vs. Ensembl Zebrafish
Match: bace2 (beta-secretase 2 [Source:ZFIN;Acc:ZDB-GENE-041010-68])

HSP 1 Score: 96.2857 bits (238), Expect = 1.804e-22
Identity = 56/136 (41.18%), Postives = 77/136 (56.62%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQ 660
            +LKG S  GYYM + IG+P Q  N+++DTGSSN AVA +   ++++YF   LSSTY   + +V V Y  G+W G   +D+ T            +  S  I +  N   I  S  FF    N+QGILGLAYP+LA+
Sbjct:   71 NLKGDSGRGYYMQMIIGTPGQTLNILVDTGSSNFAVAAAAHPYITHYFNRALSSTYQSTERAVAVKYTQGEWEGELGTDLITIP----------EGPSGAITI--NIAAILTSEGFFLPGINWQGILGLAYPLLAR 194
[Close]
BLAST of beta-secretase 1 vs. Ensembl Zebrafish
Match: ctsd (cathepsin D [Source:ZFIN;Acc:ZDB-GENE-010131-8])

HSP 1 Score: 72.7886 bits (177), Expect = 2.441e-13
Identity = 106/387 (27.39%), Postives = 165/387 (42.64%), Query Frame = 1 
Query:  256 LKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAG------SPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFG-LIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLP-NMFSVVLCGHNRN-ESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSI-IFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVS---KSGT--ILGDSFLEGFYFLFNKELSKVGIAQSK 1371
            LK   +  YY  +G+G+P Q F +V DTGSSN  V             L + +    SSTYV +     + Y SG  +G  S D  T   +A           K+I     FG  IK+    F     F GILG+AYP +A    +     +FD ++ +  +  N+FS  L   NRN ++QP   G  + GG +   Y      + I R+ +++I +  +SI +    LS CK     ++I+DTGT+    P     +L  +I    +    + V       D + V       P  P+  F                 +L+ +QYI       +S G    C     G+     +G   ILGD F+  +Y +F++E ++VG A++K
Sbjct:   68 LKNYLDAQYYGEIGLGTPVQTFTVVFDTGSSNLWVPSVHCSLTDIACLLHHKYNGGKSSTYVKNGTQFAIQYGSGSLSGYLSQDTCTIGDIA---------VEKQI-----FGEAIKQPGVAFIA-AKFDGILGMAYPRIA----VDGVPPVFDMMMSQKKVEKNVFSFYL---NRNPDTQP--GGELLLGGTDPKYYTGDFNYVDISRQAYWQIHMDGMSIGSG---LSLCK--GGCEAIVDTGTSLITGPAAEVKALQKAIGAIPLMQGEYMV-------DCKKV-------PTLPTISF----------SLGGKVYSLTGEQYILK-----ESQGGHDICLSGFMGLDIPPPAGPLWILGDVFIGQYYTVFDRENNRVGFAKAK 396
[Close]
BLAST of beta-secretase 1 vs. Ensembl Zebrafish
Match: napsa (napsin A aspartic peptidase [Source:ZFIN;Acc:ZDB-GENE-030131-8690])

HSP 1 Score: 72.0182 bits (175), Expect = 5.606e-13
Identity = 94/384 (24.48%), Postives = 154/384 (40.10%), Query Frame = 1 
Query:  280 YYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLS------NYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLP-NMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSG-------------TILGDSFLEGFYFLFNKELSKVGIAQSK 1371
            YY  + IG+PPQ F+++ DTGSSN  V      FL         + S+ SSTYV +     + Y  G  +G  S D     G+     N T +   E         +K+    F     F G+LG+AYP ++    +   + +FD  +    LP N+FS  +   NR+ +     G  + GG +   +N  L  + + RK +++I +  + + +    L+ CK  +  ++I+DTGT+    P     +L  +I       P    +   +W    + C     P  P   F                  L+ Q+Y+  V                G  V  SG              ILGD F+  +Y +F+++  +VG A +K
Sbjct:   92 YYGMISIGTPPQDFSVLFDTGSSNLWVPSIHCAFLDIACWLHRRYNSKKSSTYVQNGTEFSIQYGRGSLSGFISQDTVNLAGL-----NVTGQQFAEA--------VKQPGIVF-AVARFDGVLGMAYPAIS----VDRVTPVFDTAMAAKILPQNIFSFYI---NRDPAG-DVGGELMLGGFDQQYFNGDLHYVNVTRKAYWQIKMDEVQVGST---LTLCK--SGCQAIVDTGTSMITGPVQEVRALQKAI----GAIPL---LMGEYW----IDC--KKIPTLPVVSF----------SLGGKMFNLTGQEYVMKVS-------------HMGMNVCLSGFMAMDIPPPAGPLWILGDVFIGRYYTVFDRDQDRVGFAPAK 412
[Close]
BLAST of beta-secretase 1 vs. Ensembl Xenopus
Match: bace1 (beta-site APP-cleaving enzyme 1 [Source:NCBI gene;Acc:779940])

HSP 1 Score: 230.335 bits (586), Expect = 3.149e-68
Identity = 138/420 (32.86%), Postives = 224/420 (53.33%), Query Frame = 1 
Query:  148 IPPQNIYPEESDFSLKGFNVAEK--SVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCG----HNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS--SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +P +N     S  + +    AEK   +D   + +I+ +L+G S  GYY+ + +G+PPQ  N+++DTGSSN AV  +P  FL  Y+  Q S TY D +  V VPY  GKW G   +D+ T              +   + V +N   I +S  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N +++  +  G  + GG + SLY   +    IR++W+YE+II +I I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C    +   P   FP I + +++ + +  S ++ +  QQY++ V D   +   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   23 LPLKNCPGTCSPMAYRAKRSAEKGMELDTNFLDMID-NLRGKSGQGYYVEMRVGTPPQTLNILVDTGSSNFAVGAAPHPFLKRYYHRQHSRTYRDVRRGVYVPYTQGKWEGELGTDLVTIP------------HGPNVTVTANIAAITDSDKFFINGSNWEGILGLAYAEIARPDDTLEP--FFDSLVKQTRVPNIFSLQLCGTGFHFNESDTSASVGGSMVIGGIDPSLYIGSIWYTPIRKEWYYEVIIVKIEINGQDLHM-DCKEYNYDKSIVDSGTTNLRLPKRVFDAAVKSI----KAASSTEKFPDGFWLGEQLVCWQEGTT--PWHIFPVISL-YLMGEVANQSFKITILPQQYLRPVEDIATA---QEDCYKFAVSQSTTGTVMGAVIMEGFYVVFDRANKRIGFAVSTCHVH 416
[Close]
BLAST of beta-secretase 1 vs. Ensembl Xenopus
Match: bace1 (beta-site APP-cleaving enzyme 1 [Source:NCBI gene;Acc:779940])

HSP 1 Score: 230.335 bits (586), Expect = 3.777e-68
Identity = 138/420 (32.86%), Postives = 224/420 (53.33%), Query Frame = 1 
Query:  148 IPPQNIYPEESDFSLKGFNVAEK--SVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCG----HNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS--SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +P +N     S  + +    AEK   +D   + +I+ +L+G S  GYY+ + +G+PPQ  N+++DTGSSN AV  +P  FL  Y+  Q S TY D +  V VPY  GKW G   +D+ T              +   + V +N   I +S  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N +++  +  G  + GG + SLY   +    IR++W+YE+II +I I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C    +   P   FP I + +++ + +  S ++ +  QQY++ V D   +   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   31 LPLKNCPGTCSPMAYRAKRSAEKGMELDTNFLDMID-NLRGKSGQGYYVEMRVGTPPQTLNILVDTGSSNFAVGAAPHPFLKRYYHRQHSRTYRDVRRGVYVPYTQGKWEGELGTDLVTIP------------HGPNVTVTANIAAITDSDKFFINGSNWEGILGLAYAEIARPDDTLEP--FFDSLVKQTRVPNIFSLQLCGTGFHFNESDTSASVGGSMVIGGIDPSLYIGSIWYTPIRKEWYYEVIIVKIEINGQDLHM-DCKEYNYDKSIVDSGTTNLRLPKRVFDAAVKSI----KAASSTEKFPDGFWLGEQLVCWQEGTT--PWHIFPVISL-YLMGEVANQSFKITILPQQYLRPVEDIATA---QEDCYKFAVSQSTTGTVMGAVIMEGFYVVFDRANKRIGFAVSTCHVH 424
[Close]
BLAST of beta-secretase 1 vs. Ensembl Xenopus
Match: bace1 (beta-site APP-cleaving enzyme 1 [Source:NCBI gene;Acc:779940])

HSP 1 Score: 230.335 bits (586), Expect = 4.027e-68
Identity = 138/420 (32.86%), Postives = 224/420 (53.33%), Query Frame = 1 
Query:  148 IPPQNIYPEESDFSLKGFNVAEK--SVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCG----HNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS--SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +P +N     S  + +    AEK   +D   + +I+ +L+G S  GYY+ + +G+PPQ  N+++DTGSSN AV  +P  FL  Y+  Q S TY D +  V VPY  GKW G   +D+ T              +   + V +N   I +S  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N +++  +  G  + GG + SLY   +    IR++W+YE+II +I I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C    +   P   FP I + +++ + +  S ++ +  QQY++ V D   +   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   28 LPLKNCPGTCSPMAYRAKRSAEKGMELDTNFLDMID-NLRGKSGQGYYVEMRVGTPPQTLNILVDTGSSNFAVGAAPHPFLKRYYHRQHSRTYRDVRRGVYVPYTQGKWEGELGTDLVTIP------------HGPNVTVTANIAAITDSDKFFINGSNWEGILGLAYAEIARPDDTLEP--FFDSLVKQTRVPNIFSLQLCGTGFHFNESDTSASVGGSMVIGGIDPSLYIGSIWYTPIRKEWYYEVIIVKIEINGQDLHM-DCKEYNYDKSIVDSGTTNLRLPKRVFDAAVKSI----KAASSTEKFPDGFWLGEQLVCWQEGTT--PWHIFPVISL-YLMGEVANQSFKITILPQQYLRPVEDIATA---QEDCYKFAVSQSTTGTVMGAVIMEGFYVVFDRANKRIGFAVSTCHVH 421
[Close]
BLAST of beta-secretase 1 vs. Ensembl Xenopus
Match: bace1 (beta-site APP-cleaving enzyme 1 [Source:NCBI gene;Acc:779940])

HSP 1 Score: 229.95 bits (585), Expect = 4.333e-68
Identity = 138/420 (32.86%), Postives = 224/420 (53.33%), Query Frame = 1 
Query:  148 IPPQNIYPEESDFSLKGFNVAEK--SVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCG----HNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS--SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +P +N     S  + +    AEK   +D   + +I+ +L+G S  GYY+ + +G+PPQ  N+++DTGSSN AV  +P  FL  Y+  Q S TY D +  V VPY  GKW G   +D+ T              +   + V +N   I +S  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N +++  +  G  + GG + SLY   +    IR++W+YE+II +I I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C    +   P   FP I + +++ + +  S ++ +  QQY++ V D   +   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   28 LPLKNCPGTCSPMAYRAKRSAEKGMELDTNFLDMID-NLRGKSGQGYYVEMRVGTPPQTLNILVDTGSSNFAVGAAPHPFLKRYYHRQHSRTYRDVRRGVYVPYTQGKWEGELGTDLVTIP------------HGPNVTVTANIAAITDSDKFFINGSNWEGILGLAYAEIARPDDTLEP--FFDSLVKQTRVPNIFSLQLCGTGFHFNESDTSASVGGSMVIGGIDPSLYIGSIWYTPIRKEWYYEVIIVKIEINGQDLHM-DCKEYNYDKSIVDSGTTNLRLPKRVFDAAVKSI----KAASSTEKFPDGFWLGEQLVCWQEGTT--PWHIFPVISL-YLMGEVANQSFKITILPQQYLRPVEDIATA---QEDCYKFAVSQSTTGTVMGAVIMEGFYVVFDRANKRIGFAVSTCHVH 421
[Close]
BLAST of beta-secretase 1 vs. Ensembl Xenopus
Match: gast (gastrin [Source:Xenbase;Acc:XB-GENE-6458649])

HSP 1 Score: 202.601 bits (514), Expect = 8.876e-58
Identity = 130/392 (33.16%), Postives = 202/392 (51.53%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTN-GFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSII----FNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFV-INDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLHVATVSRSRI 1410
            +L+G S  GYY+ + IG+PPQK N+++DTGSSN AVAG+    ++ +F S+LS++Y      V V Y  G W GL   D+        I   K    +  IN+ S F    +S  FF  N N+QGILGLAY  LA+P++ +     FD +V +  +PN+FS+ +CG  +       N G  + GG   SLY   +    I  +W+Y++ + +  +  + + L  C  YN DK+I+D+GT     P+ +F+++V +I+        NA F   +    WD+             P  YFP+I I     N + S  + L  Q YIQ     + +F    NC++FG   S S  ++G + +EGFY +F++   +VG A S C   V+ ++ S I
Sbjct:   71 NLEGDSGRGYYLELLIGTPPQKMNILVDTGSSNFAVAGALNPDITTFFDSKLSTSYEPLNTQVTVRYTQGSWTGLLGKDV--------ISMPKGVNGTFLINIASIF----QSENFFLPNINWQGILGLAYSTLAKPSSSVEP--FFDSLVQQENIPNIFSMQMCGAGQPSPGIGINAGSLVLGGIEPSLYQGDIWYTPITEEWYYQVEVLKFEVGGQNLNL-DCTVYNSDKAIVDSGTTLLRLPDKVFNAMVDAIVQTSLIQNFNAEFWAGLQLACWDKT----------QDPWNYFPDISIYLRDTNSSRSFRLTLKPQLYIQ----SVLTFQESLNCFRFGISQSASALVIGATVMEGFYVIFDRAEKRVGFAVSSC-AEVSGITVSEI 432
[Close]
BLAST of beta-secretase 1 vs. Ensembl Mouse
Match: Bace1 (beta-site APP cleaving enzyme 1 [Source:MGI Symbol;Acc:MGI:1346542])

HSP 1 Score: 246.128 bits (627), Expect = 2.680e-74
Identity = 140/382 (36.65%), Postives = 210/382 (54.97%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N+ E+  +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   66 NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGTT--PWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 423
[Close]
BLAST of beta-secretase 1 vs. Ensembl Mouse
Match: Bace1 (beta-site APP cleaving enzyme 1 [Source:MGI Symbol;Acc:MGI:1346542])

HSP 1 Score: 207.608 bits (527), Expect = 4.210e-60
Identity = 126/382 (32.98%), Postives = 193/382 (50.52%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N+ E+  +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKE  +             FP+                          FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   66 NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKETEK-------------FPD-------------------------GFWLGEQLVCWQAGTT--PWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 389
[Close]
BLAST of beta-secretase 1 vs. Ensembl Mouse
Match: Bace2 (beta-site APP-cleaving enzyme 2 [Source:MGI Symbol;Acc:MGI:1860440])

HSP 1 Score: 199.904 bits (507), Expect = 9.679e-57
Identity = 128/376 (34.04%), Postives = 193/376 (51.33%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTN-GFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKC 1374
            +L+G S  GYY+ + IG+PPQK  +++DTGSSN AVAG+P  ++  YF S+ SSTY      V V Y  G W G    D+ T          K    S  +N+ + F    ES  FF     + GILGLAY  LA+P++ +   T FD +V +  +P++FS+ +CG     +   TN G  + GG   SLY   +    I+ +W+Y+I I ++ I  + + L  C+EYN DK+I+D+GT     P  +F ++V ++        F       FW    + C  +NS   P  YFP+I I     + S S  + +  Q YIQ     +   G    CY+FG   S +  ++G + +EGFY +F++   +VG A S C
Sbjct:   79 NLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIP--------KGFNSSFLVNIATIF----ESENFFLPGIKWNGILGLAYAALAKPSSSLE--TFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNL-DCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFS----DGFWTGAQLAC-WTNS-ETPWAYFPKISIYLRDENASRSFRITILPQLYIQ----PMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPC 429
[Close]
BLAST of beta-secretase 1 vs. Ensembl Mouse
Match: Bace1 (beta-site APP cleaving enzyme 1 [Source:MGI Symbol;Acc:MGI:1346542])

HSP 1 Score: 162.54 bits (410), Expect = 1.769e-44
Identity = 106/330 (32.12%), Postives = 158/330 (47.88%), Query Frame = 1 
Query:  409 SSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            SSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+                           LCG     N+ E+  +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:    2 SSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIAR---------------------------LCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMD-CKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGTT--PWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 282
[Close]
BLAST of beta-secretase 1 vs. Ensembl Mouse
Match: Ctsd (cathepsin D [Source:MGI Symbol;Acc:MGI:88562])

HSP 1 Score: 78.5666 bits (192), Expect = 4.437e-15
Identity = 102/385 (26.49%), Postives = 164/385 (42.60%), Query Frame = 1 
Query:  256 LKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLS------NYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSN-FGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVV-MKYGLPNMFSVVLCGHNRN-ESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVS---KSGT--ILGDSFLEGFYFLFNKELSKVGIAQS 1368
            LK   +  YY  +GIG+PPQ F +V DTGSSN  V     + L       + + S  SSTYV +  S  + Y SG  +G  S D  +      +     Q  ++ I V    FG   +          F GILG+ YP ++    L     +FD+++  K    N+FS  L   NR+ E QP   G  + GG +   Y+  L  + + RK ++++ + ++ + N+   L+ CK     ++I+DTGT           SL+   +  +K    K     P      +I      P    +  P + ++            L   +YI  V     S G +  C     G+     SG   ILGD F+  +Y +F+++ ++VG A +
Sbjct:   71 LKNYLDAQYYGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVS------VPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAKFDGILGMGYPHISVNNVL----PVFDNLMQQKLVDKNIFSFYL---NRDPEGQP--GGELMLGGTDSKYYHGELSYLNVTRKAYWQVHMDQLEVGNE---LTLCK--GGCEAIVDTGT-----------SLLVGPVEEVKELQ-KAIGAVPLIQGEYMI------PCEKVSSLPTVYLKL-----GGKNYELHPDKYILKV-----SQGGKTICLSGFMGMDIPPPSGPLWILGDVFIGSYYTVFDRDNNRVGFANA 407
[Close]
BLAST of beta-secretase 1 vs. UniProt/SwissProt
Match: sp|P56819|BACE1_RAT (Beta-secretase 1 OS=Rattus norvegicus OX=10116 GN=Bace1 PE=2 SV=1)

HSP 1 Score: 248.054 bits (632), Expect = 4.205e-74
Identity = 141/382 (36.91%), Postives = 211/382 (55.24%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D + SV VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N+ E+  +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   66 NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKSVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 423
[Close]
BLAST of beta-secretase 1 vs. UniProt/SwissProt
Match: sp|P56818|BACE1_MOUSE (Beta-secretase 1 OS=Mus musculus OX=10090 GN=Bace1 PE=1 SV=2)

HSP 1 Score: 246.128 bits (627), Expect = 1.874e-73
Identity = 140/382 (36.65%), Postives = 210/382 (54.97%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N+ E+  +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   66 NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGTT--PWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 423
[Close]
BLAST of beta-secretase 1 vs. UniProt/SwissProt
Match: sp|Q2HJ40|BACE1_BOVIN (Beta-secretase 1 OS=Bos taurus OX=9913 GN=BACE1 PE=2 SV=1)

HSP 1 Score: 245.743 bits (626), Expect = 2.464e-73
Identity = 140/382 (36.65%), Postives = 211/382 (55.24%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N++E+  +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   66 NLRGKSGQGYYVEMTLGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHVPNLFSLQLCGAGFPLNQSEALASVGGSMIIGGIDHSLYMGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 423
[Close]
BLAST of beta-secretase 1 vs. UniProt/SwissProt
Match: sp|P56817|BACE1_HUMAN (Beta-secretase 1 OS=Homo sapiens OX=9606 GN=BACE1 PE=1 SV=3)

HSP 1 Score: 245.743 bits (626), Expect = 2.796e-73
Identity = 140/382 (36.65%), Postives = 210/382 (54.97%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N++E   +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   66 NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 423
[Close]
BLAST of beta-secretase 1 vs. UniProt/SwissProt
Match: sp|Q1KLR6|BACE1_CAVPO (Beta-secretase 1 OS=Cavia porcellus OX=10141 GN=BACE1 PE=2 SV=1)

HSP 1 Score: 217.624 bits (553), Expect = 5.350e-63
Identity = 131/382 (34.29%), Postives = 195/382 (51.05%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ Q SSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+                           LCG     N++E+  +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   63 NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQRSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIAR---------------------------LCGAGFPLNQSEAVASVGGSMIIGGIDHSLYTGNLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 395
[Close]
BLAST of beta-secretase 1 vs. TrEMBL
Match: A0A1U7RGL7 (beta-secretase 1 OS=Mesocricetus auratus OX=10036 GN=LOC101842857 PE=3 SV=2)

HSP 1 Score: 249.595 bits (636), Expect = 3.071e-72
Identity = 150/419 (35.80%), Postives = 223/419 (53.22%), Query Frame = 1 
Query:  151 PPQNI-YPEESDFSLKGFNVAEKSVDNRIITLIET--DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            PP  +  P E+D         E    NR  + +E   +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N+ E+  +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  V +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   37 PPLGLRLPRETD--------EESEEPNRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHIPNVFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEATNQSFRVTILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 423
[Close]
BLAST of beta-secretase 1 vs. TrEMBL
Match: A0A4X2M791 (Peptidase A1 domain-containing protein OS=Vombatus ursinus OX=29139 GN=BACE1 PE=3 SV=1)

HSP 1 Score: 248.054 bits (632), Expect = 9.986e-72
Identity = 141/397 (35.52%), Postives = 219/397 (55.16%), Query Frame = 1 
Query:  211 EKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH-----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            E S+ +  + +++ +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG      N++E+  +  G  I GG + SLY   L    IRR+W+YE++I R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   47 ESSLRSSFVEMVD-NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYRRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTQVPNLFSLQLCGTGFPSLNQSEAMASVGGSMIIGGIDHSLYVGSLWYTPIRREWYYEVVIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KTASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRAHKRIGFAVSACHVH 418
[Close]
BLAST of beta-secretase 1 vs. TrEMBL
Match: M1VRQ8 (Beta-secretase 1 OS=Canis lupus familiaris OX=9615 GN=BACE1 PE=2 SV=1)

HSP 1 Score: 247.284 bits (630), Expect = 1.740e-71
Identity = 149/421 (35.39%), Postives = 222/421 (52.73%), Query Frame = 1 
Query:  142 RMIPPQNIYPEESDFSLKGFNVAEKSVDNRIITLIET--DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            R  PP    P E+        V E     R  + +E   +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N++E   +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   20 RCTPPGIRLPRET--------VEEPDEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 408
[Close]
BLAST of beta-secretase 1 vs. TrEMBL
Match: A0A2K6KYQ5 (Beta-secretase 1 OS=Rhinopithecus bieti OX=61621 GN=BACE1 PE=3 SV=1)

HSP 1 Score: 246.899 bits (629), Expect = 1.925e-71
Identity = 145/410 (35.37%), Postives = 221/410 (53.90%), Query Frame = 1 
Query:  169 PEESDFSLKGFNVAEKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            P E+D  L+     E       + +++ +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N++E   +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   28 PRETDEELE-----EPGRRGSFVEMVD-NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRAQKRIGFAVSACHVH 407
[Close]
BLAST of beta-secretase 1 vs. TrEMBL
Match: A0A2K5IHZ9 (Beta-secretase 1 OS=Colobus angolensis palliatus OX=336983 GN=BACE1 PE=3 SV=1)

HSP 1 Score: 246.899 bits (629), Expect = 2.094e-71
Identity = 145/410 (35.37%), Postives = 221/410 (53.90%), Query Frame = 1 
Query:  169 PEESDFSLKGFNVAEKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGH----NRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            P E+D  L+     E       + +++ +L+G S  GYY+ + +GSPPQ  N+++DTGSSN AV  +P  FL  Y++ QLSSTY D +  V VPY  GKW G   +D+ +              +   + VR+N   I ES  FF    N++GILGLAY  +A+P + +     FD +V +  +PN+FS+ LCG     N++E   +  G  I GG + SLY   L    IRR+W+YE+II R+ I+ + + +  CKEYN DKSI+D+GT +   P  +F + V SI    K A         FW    ++C  + +   P   FP I +  +   T+ S  + +  QQY++ V D   S   + +CYKF    S +GT++G   +EGFY +F++   ++G A S C++H
Sbjct:   28 PRETDEELE-----EPGRRGSFVEMVD-NLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP------------HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEP--FFDSLVKQTHVPNLFSLQLCGAGFPPNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM-DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI----KAASSTEKFPDGFWLGEQLVCWQAGT--TPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATS---QDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVH 407
[Close]
BLAST of beta-secretase 1 vs. Ensembl Cavefish
Match: bace1 (beta-secretase 1 [Source:NCBI gene;Acc:103025562])

HSP 1 Score: 234.572 bits (597), Expect = 4.810e-70
Identity = 132/382 (34.55%), Postives = 207/382 (54.19%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCG----HNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVI-NDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +G+PPQK N+++DTGSSN AV  +   FL  Y+   LS++Y D   SV VPY  G+W G   +D+ +              +   +++R+N   I +S  FF    N++GILGLAY  +A+P   +     FD +V +  +PN+FS+ LCG     N +    T  G  I GG + SLY   +    IRR+W+YE+II RI ++ + + +  CKEYN DKSI+D+GT +   P  +F + V +I        F     S FW    ++C  + +   P   FP I +  +  N   S  +++  QQY++ V D   +   + +CYKF    S +GT++G   +EGFY +F++E  ++G A S C++H
Sbjct:   65 NLRGKSGQGYYVEMAVGTPPQKLNILVDTGSSNFAVGAAAHPFLRRYYHRSLSTSYKDLGRSVYVPYTQGRWEGELGTDLVSVP------------HGPNMSLRANIAAITQSDRFFINGSNWEGILGLAYAEIARPDETLEP--FFDSLVRQTNVPNLFSLQLCGAGFTQNYSLGSATVGGSMIIGGVDPSLYVGEVWYTPIRREWYYEVIIVRIEVNGQDLNM-DCKEYNYDKSIVDSGTTNLRLPRKVFQAAVKAIEAASSTEQFP----SGFWLGEQLVCWQAGTT--PWHIFPVISLYLMSENRNQSFRISILPQQYLRPVEDVASA---QEDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRERKRIGFAVSTCHVH 422
[Close]
BLAST of beta-secretase 1 vs. Ensembl Cavefish
Match: bace1 (beta-secretase 1 [Source:NCBI gene;Acc:103025562])

HSP 1 Score: 234.572 bits (597), Expect = 4.810e-70
Identity = 132/382 (34.55%), Postives = 207/382 (54.19%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCG----HNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVI-NDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +G+PPQK N+++DTGSSN AV  +   FL  Y+   LS++Y D   SV VPY  G+W G   +D+ +              +   +++R+N   I +S  FF    N++GILGLAY  +A+P   +     FD +V +  +PN+FS+ LCG     N +    T  G  I GG + SLY   +    IRR+W+YE+II RI ++ + + +  CKEYN DKSI+D+GT +   P  +F + V +I        F     S FW    ++C  + +   P   FP I +  +  N   S  +++  QQY++ V D   +   + +CYKF    S +GT++G   +EGFY +F++E  ++G A S C++H
Sbjct:   65 NLRGKSGQGYYVEMAVGTPPQKLNILVDTGSSNFAVGAAAHPFLRRYYHRSLSTSYKDLGRSVYVPYTQGRWEGELGTDLVSVP------------HGPNMSLRANIAAITQSDRFFINGSNWEGILGLAYAEIARPDETLEP--FFDSLVRQTNVPNLFSLQLCGAGFTQNYSLGSATVGGSMIIGGVDPSLYVGEVWYTPIRREWYYEVIIVRIEVNGQDLNM-DCKEYNYDKSIVDSGTTNLRLPRKVFQAAVKAIEAASSTEQFP----SGFWLGEQLVCWQAGTT--PWHIFPVISLYLMSENRNQSFRISILPQQYLRPVEDVASA---QEDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRERKRIGFAVSTCHVH 422
[Close]
BLAST of beta-secretase 1 vs. Ensembl Cavefish
Match: bace1 (beta-secretase 1 [Source:NCBI gene;Acc:103025562])

HSP 1 Score: 196.438 bits (498), Expect = 4.157e-56
Identity = 120/382 (31.41%), Postives = 190/382 (49.74%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCG----HNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVI-NDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +G+PPQK N+++DTGSSN AV  +   FL  Y+   LS++Y D   SV VPY  G+W G   +D+ +              +   +++R+N   I +S  FF    N++GILGLAY  +A+P   +     FD +V +  +PN+FS+ LCG     N +    T  G  I GG + SLY   +    IRR+W+YE+II RI ++ + + +  CKE  +             FP                         S FW    ++C  + +   P   FP I +  +  N   S  +++  QQY++ V D   +   + +CYKF    S +GT++G   +EGFY +F++E  ++G A S C++H
Sbjct:   65 NLRGKSGQGYYVEMAVGTPPQKLNILVDTGSSNFAVGAAAHPFLRRYYHRSLSTSYKDLGRSVYVPYTQGRWEGELGTDLVSVP------------HGPNMSLRANIAAITQSDRFFINGSNWEGILGLAYAEIARPDETLEP--FFDSLVRQTNVPNLFSLQLCGAGFTQNYSLGSATVGGSMIIGGVDPSLYVGEVWYTPIRREWYYEVIIVRIEVNGQDLNM-DCKETEQ-------------FP-------------------------SGFWLGEQLVCWQAGTT--PWHIFPVISLYLMSENRNQSFRISILPQQYLRPVEDVASA---QEDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRERKRIGFAVSTCHVH 388
[Close]
BLAST of beta-secretase 1 vs. Ensembl Cavefish
Match: bace2 (beta-secretase 2 [Source:ZFIN;Acc:ZDB-GENE-041010-68])

HSP 1 Score: 183.341 bits (464), Expect = 7.888e-51
Identity = 118/378 (31.22%), Postives = 186/378 (49.21%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHN---RNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFV-INDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKC 1374
            +LKG S  GYYM + IG+P Q  N+++DTGSSN AVA +P  +++ YF    SSTY     SV V Y  G W G   +D+ T              +     +  N   I  S  FF    N+QGILG       +P         F+ +V++ G+P++FS+ +CG        S+P   G  I GG   +LY   +    I ++W+Y++ + ++ ++++ + L  CKEYN DK+I+D+GT     P  +F+++V +I              S F+    + C +      P  +FP+I I     N + S  + +  Q YIQ V D         NC++FG   S +G ++G + +EGFY +F++   +VG A S C
Sbjct:   78 NLKGDSGRGYYMEMVIGTPGQTLNILVDTGSSNFAVAAAPHPYIATYFNRAQSSTYQTSGRSVSVRYTQGNWEGELGTDLITIP------------HGPNGTITINIAAILTSDDFFLPGINWQGILGAGPDPSVEP--------FFNSLVLQTGIPDVFSLQMCGAGLSISTASEP-AGGSLIMGGAEPTLYQGSVWYTPILQEWYYQVEVLKLEVADQNLSL-DCKEYNTDKAIVDSGTTLLRLPVKVFNAVVEAI----SQMSLVQDFSSGFFAGTKLACWVKG--ESPWRFFPKISIYLRGTNSSQSFRLTVFPQLYIQPVTD----LDGTLNCFRFGISSSTNGLVIGATVMEGFYVVFDRAQKRVGFAVSSC 423
[Close]
BLAST of beta-secretase 1 vs. Ensembl Cavefish
Match: nots (cathepsin E-like [Source:NCBI gene;Acc:103036771])

HSP 1 Score: 75.485 bits (184), Expect = 3.625e-14
Identity = 95/387 (24.55%), Postives = 159/387 (41.09%), Query Frame = 1 
Query:  280 YYMTVGIGSPPQKFNLVIDTGSSNTAVAG----SPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEI-NVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPN-MFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIIL----SSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQ-------IEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFG----VSKSGT--ILGDSFLEGFYFLFNKELSKVGIAQSK 1371
            Y+  + +G+P Q F +V DTGS++  V      SP     + FK+  SSTY+      G+ Y SG   G+ + D+     V      + Q + + +     +F + K           F GILGL+YP LA+     H + +FD+++ +  +   +FS  L         P   G  + GG ++ L+ PP+  + +  K +++I +  + +           SSC      ++I+DTGT+                            I  P  D   +  ++  +P     +  +         I FV+N    +E +L  + YI+      D  G+R  C   GF     VS  G   ILGD FL   Y ++++   +VG AQ K
Sbjct:   83 YFGQISLGTPAQNFTVVFDTGSADLWVPSTYCVSPACASHHKFKAIESSTYIHDGRIFGIHYGSGHLLGVLAKDMLKVGSVTV----QNQEFGESVYEPGMSFVMTK-----------FDGILGLSYPALAEE----HGAPVFDNMIKQNLVEKPIFSFFL------NIGPEKEGELLLGGVDEDLFVPPINWVPVTVKGYWQIKMDVLKVQGTSAFCHGDTSSC------QAIVDTGTS---------------------------LIAGPTMDILILQQLIGATPTPAGEFLVDCSRIKSLPVISFVLN---GVEYSLPGESYIRK-----DVVGDRVLCLT-GFVAVDIVSPKGPLWILGDVFLSQVYSIYDRGQDRVGFAQLK 402
[Close]
BLAST of beta-secretase 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006274.1 (pep scaffold:Pmarinus_7.0:GL484715:1746:11685:1 gene:ENSPMAG00000005661.1 transcript:ENSPMAT00000006274.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 120.168 bits (300), Expect = 2.118e-31
Identity = 63/166 (37.95%), Postives = 94/166 (56.63%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCG 750
            +L+G    GYY+ + +G+PPQ  N+++DTGSSN AV  +P  FL  Y++ + SSTY     SV VPY  G W G   +D+ +              +    +VR+N   I  S +FF    N++GILGLAY  +A+P + +     FD +V + G+PN+FS+ LCG
Sbjct:   71 NLRGKPGQGYYIEMALGTPPQMLNILVDTGSSNFAVGAAPHLFLKRYYRPERSSTYRPSHSSVYVPYTQGNWQGDLGTDLVSVP------------HGGNSSVRANVAAITYSNSFFINGSNWEGILGLAYANIARPDDSLEP--FFDSLVKQTGIPNVFSLQLCG 222
[Close]
BLAST of beta-secretase 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001179.1 (pep scaffold:Pmarinus_7.0:GL476699:589225:591292:-1 gene:ENSPMAG00000001055.1 transcript:ENSPMAT00000001179.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 54.299 bits (129), Expect = 3.359e-9
Identity = 25/68 (36.76%), Postives = 39/68 (57.35%), Query Frame = 1 
Query: 1180 VALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            V +  QQY++ V D      +   CYKF    S +GT++G   +EGFY +F++   +VG A S+C+ H
Sbjct:    1 VRVGPQQYLRAVEDVASMLDD---CYKFAISQSSTGTVIGAVVMEGFYVVFDRAHKRVGFAVSRCSEH 65
[Close]
BLAST of beta-secretase 1 vs. Ensembl Yeast
Match: PEP4 (Vacuolar aspartyl protease (proteinase A); required for posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates [Source:SGD;Acc:S000006075])

HSP 1 Score: 59.3066 bits (142), Expect = 6.959e-10
Identity = 65/260 (25.00%), Postives = 105/260 (40.38%), Query Frame = 1 
Query:  271 NYGYYMTVGIGSPPQKFNLVIDTGSSNTAV----AGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNR------NESQPTTNGFFIA-GGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSI 1017
            N  YY  + +G+PPQ F +++DTGSSN  V     GS   FL + +  + SS+Y  +     + Y +G   G  S D  +  G   I        + E  +   F             G F GILGL Y  ++            D VV  +   N     L    R      + S+ T NG     GG ++S +   +  + +RRK ++E+    I + ++   L S        + +DTGT+    P+ +   + + I
Sbjct:   88 NAQYYTDITLGTPPQNFKVILDTGSSNLWVPSNECGSLACFLHSKYDHEASSSYKANGTEFAIQYGTGSLEGYISQDTLSI-GDLTIPKQDFAEATSEPGLTFAF-------------GKFDGILGLGYDTIS-----------VDKVVPPF--YNAIQQDLLDEKRFAFYLGDTSKDTENGGEATFGGIDESKFKGDITWLPVRRKAYWEVKFEGIGLGDEYAELES------HGAAIDTGTSLITLPSGLAEMINAEI 314
[Close]
BLAST of beta-secretase 1 vs. Ensembl Nematostella
Match: EDO39359 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA91])

HSP 1 Score: 187.578 bits (475), Expect = 1.048e-53
Identity = 122/380 (32.11%), Postives = 202/380 (53.16%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLP-NMFSVVLCGHNRNE--SQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSI-IFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALS--SQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKC 1374
            +LKG    GYY+   +GSPPQ+ N+++DTGSSN AVA S   ++  YF    S++Y D    V VPY  G W G   SD+  F     +D          + +R +   I +S  FF     ++GILGL Y  LA+P + +  + +FD  V+ +G+  + FS+ LCG +  +  ++PT  G  + G  ++ LY   L+   I +KW+YE++I+ +++    + L  CK+YN DK+I+D+GT +      +F++++  +  F+  N      I   FW  R ++C   N    P   FP++ I  + + +SS E  L    Q Y++   +     G  ++CYKF    ++ GT++G   +EGFY +F++E  +VG A + C
Sbjct:    3 NLKGRPGQGYYIASNLGSPPQRINVLVDTGSSNFAVAASAHPYIPYYFHIDKSTSYKDLNKPVSVPYTQGSWEGELGSDLIKF-----VDG-------PNVTLRVDVASILQSENFFINGSMWEGILGLGYARLAKPDSSV--TPVFDQFVLDHGVEKDSFSMQLCGSSEIDPSAEPTVAGTMVFGEIDEELYKGDLLYTPIVKKWYYEVVITDVAVDGDSLAL-DCKKYNYDKTIVDSGTTNLRVSEEVFNAILDRLRKFDKVN-----LIPDDFWYGRQMMCW--NYDRTPWEEFPDMSISLLSSLSSSKEFRLKIPPQLYLRETIEHGPIMG--QHCYKFAITRAERGTVIGAVIMEGFYVVFDRENVQVGFAATTC 358
[Close]
BLAST of beta-secretase 1 vs. Ensembl Nematostella
Match: EDO37418 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFW0])

HSP 1 Score: 92.0485 bits (227), Expect = 1.291e-19
Identity = 95/395 (24.05%), Postives = 171/395 (43.29%), Query Frame = 1 
Query:  268 SNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQ-------FLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLC-GHNR---NESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHP--STYFPEIQ-------------IEFVINDT--SSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQS 1368
            ++Y Y + + IG+PPQK   +IDTGSSN A+AG   Q        + N++    S++  D KI +   Y  G W+G    D+  F                  N    F +I+    FF +N   +GILGLAY  LA        + L+D +V+   +PN+F++ LC G  +   +  +P T             Y  P+    I ++ +Y + ++ I ++   + LS         +I+D+GT D      I+ ++++ +    K+ P    +   FWD     C+ ++    P  + Y  +++             I   + D    S  + +  + Y++    + D+F    +C     GV +S  +LG+  +EG   +F++   ++G A S
Sbjct:  177 TSYAYVIELDIGTPPQKLEFLIDTGSSNMAIAGPKCQDQWGSKCKIDNFYFPDKSTSARDIKIPIETQYGKGAWSGDMYQDVVAFP-------------ENGPNTLVEFAVIRNEKDFFLRNSINEGILGLAYRSLATDG----VTPLYDQLVLDGKVPNVFTLGLCNGMGQIWLDHPEPGT-------------YVGPIHYTEIEQETWYTVSMTGIDVAGNSLDLSP---QVFPTAIVDSGTTDILLRPEIYMAVITEL---KKHGP---PVDERFWDN---YCVDTDPYQWPYITIYLRDMRKLYYHMYETCVSYITIYLRDMRGGSFGLTILGKHYVR----KQDAF----HC--LSLGVKQSVGVLGEVVMEGNIVVFDRARQRIGFAPS 519
[Close]
BLAST of beta-secretase 1 vs. Ensembl Nematostella
Match: EDO49162 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH56])

HSP 1 Score: 58.9214 bits (141), Expect = 1.978e-9
Identity = 61/237 (25.74%), Postives = 103/237 (43.46%), Query Frame = 1 
Query:  280 YYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQF------LSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPN-MFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTA 969
            YY  + IG+PPQKF +V DTGSSN  V      +      L + + S  SSTY  +     + Y SG  +G  S D  +  G+      K Q +++ +         +   TF      F GILG+ +  ++    +     +F D+V++  +P  +FS  L   NR E   +  G  + GG +   Y      + + ++ +++  +  IS+         C      ++I DTGT+
Sbjct:   51 YYGEITIGTPPQKFTVVFDTGSSNLWVPSKKCSWTNIACLLHDKYDSTKSSTYKKNGTEFAIRYGSGSLSGFLSIDTVSVGGIDV----KGQTFAEALK--------EPGLTFV--AAKFDGILGMGFSSIS----VDQVVPVFYDMVLQKLVPAPVFSFYL---NR-EPGASPGGELLLGGSDPKYYKGNFSYVPVTQEGYWQFKMDGISVKEGSFCSDGC------QAIADTGTS 259
[Close]
BLAST of beta-secretase 1 vs. Ensembl Nematostella
Match: EDO27680 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T8K6])

HSP 1 Score: 55.0694 bits (131), Expect = 2.288e-8
Identity = 49/227 (21.59%), Postives = 88/227 (38.77%), Query Frame = 1 
Query:  799 GGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRR-----------------------NCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLHVATVSRSRI 1410
            G  ++ LY   L+   I +KW+YE++I+ +++    + L  CK                                       K+ +   FW  R ++C   N    P   FP++ I  + + +SS E     ++++    D  D+  NR+                       +CYKF    ++ GT++G   +EGFY +F++E  +VG A + C        RS +
Sbjct:    3 GEIDEELYKGDLLYTPIVKKWYYEVVITDVAVDGDSLALD-CK---------------------------------------KLGVPDDFWYGRQMMCW--NYDRTPWEEFPDMSISLLSSLSSSKET--KKREHVTKANDSYDATLNRQRKRSRLNTLYLRETIEHGPIMGQHCYKFAITRAERGTVIGAVIMEGFYVVFDRENVQVGFAATTCGAEGRLNPRSEV 185
[Close]
BLAST of beta-secretase 1 vs. Ensembl Medaka
Match: bace1 (beta-secretase 1 [Source:NCBI gene;Acc:101160575])

HSP 1 Score: 228.794 bits (582), Expect = 1.038e-67
Identity = 133/382 (34.82%), Postives = 205/382 (53.66%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCG----HNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVI-NDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLH 1383
            +L+G S  GYY+ + +GSPPQK N+++DTGSSN AV  +   FL  Y+   LSS+Y D   +V VPY  G+W G   +D+ +              +     +R+N   I +S  FF    N++GILGLAY  +A+P   +     FD +V +  +PN+FS+ LCG     N +    T  G  I GG + SLY   +    IRR+W+YE+II RI ++ + + +  CKEYN DKSI+D+GT +   P  +F + V +I        F     S FW    ++C  + +   P   FP I +  +  N   S  +++  QQY++ V D   +   + +CYKF    S +GT++G   +EGFY +F++E  ++G A S C++H
Sbjct:   84 NLRGKSGQGYYVEMAVGSPPQKLNILVDTGSSNFAVGAAAHPFLRRYYHRSLSSSYRDMGRNVYVPYTQGRWEGELGTDLVSVP------------HGPNATLRANIAAITQSERFFINGSNWEGILGLAYADIARPDETLEP--FFDSLVRQTSVPNLFSLQLCGAGYTQNYSSGSSTVGGSMIIGGVDSSLYVGEIWYTPIRREWYYEVIIVRIEVNGQDLNM-DCKEYNYDKSIVDSGTTNLRLPRKVFQAAVKAIEAASSTEQFP----SGFWLGEQLVCWQAGT--TPWHIFPVISLYLMSENRNQSFRISILPQQYLRPVEDVASA---QEDCYKFAVSQSSTGTVMGAVIMEGFYVVFDREKKRIGFAVSTCHVH 441
[Close]
BLAST of beta-secretase 1 vs. Ensembl Medaka
Match: bace2 (beta-secretase 2 [Source:NCBI gene;Acc:101167562])

HSP 1 Score: 195.282 bits (495), Expect = 2.763e-55
Identity = 117/377 (31.03%), Postives = 197/377 (52.25%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTT--NGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKC 1374
            +L+G S  GYY+ + +G+P QK N+++DTGSSN A+A +P   ++ YF + LSS++      V V Y  G W G          G+  +   K    +  +N+ +    I  S  FF     +QGILG+AYP LA+P + +     FD VV + G+P++FS+ +CG   + S       G  I GG   +LY   +    I  +W+Y++ + ++ + ++ + L  CKEYN DK+I+D+GT     P  +F+++V +I  +     F     S FW+   + C +      P   FP++ I     +TS S  + +  Q YIQ + D+  +     +C++FG   S +G ++G + +EGFY +F++   ++G A S C
Sbjct:   71 NLQGDSGRGYYIEMSVGTPGQKLNILLDTGSSNFAIAAAPHPDITRYFDTDLSSSFQALDRFVAVRYTQGNWEGEL--------GIDSVSIPKGPNGTITVNIAA----ILSSNGFFLSGIKWQGILGMAYPALARPDSSVEP--FFDSVVKQLGIPDVFSLQMCGAGLSGSSAADPPGGSLIMGGAEPTLYRGSVWYTPIVEEWYYQVEVLKLEVDDQNLNL-DCKEYNMDKAIVDSGTTMLRLPAKVFNAVVEAITRSSLIQEFS----SGFWEGTKLACWMKG--ETPWRVFPKLSIYLRATNTSQSFRITILPQLYIQLITDENSAL----DCFRFGVSSSANGLVIGATVMEGFYVVFDRAHKRLGFALSSC 422
[Close]
BLAST of beta-secretase 1 vs. Ensembl Medaka
Match: bace2 (beta-secretase 2 [Source:NCBI gene;Acc:101167562])

HSP 1 Score: 195.282 bits (495), Expect = 3.894e-55
Identity = 117/377 (31.03%), Postives = 197/377 (52.25%), Query Frame = 1 
Query:  253 DLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTT--NGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTS-SLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKC 1374
            +L+G S  GYY+ + +G+P QK N+++DTGSSN A+A +P   ++ YF + LSS++      V V Y  G W G          G+  +   K    +  +N+ +    I  S  FF     +QGILG+AYP LA+P + +     FD VV + G+P++FS+ +CG   + S       G  I GG   +LY   +    I  +W+Y++ + ++ + ++ + L  CKEYN DK+I+D+GT     P  +F+++V +I  +     F     S FW+   + C +      P   FP++ I     +TS S  + +  Q YIQ + D+  +     +C++FG   S +G ++G + +EGFY +F++   ++G A S C
Sbjct:   89 NLQGDSGRGYYIEMSVGTPGQKLNILLDTGSSNFAIAAAPHPDITRYFDTDLSSSFQALDRFVAVRYTQGNWEGEL--------GIDSVSIPKGPNGTITVNIAA----ILSSNGFFLSGIKWQGILGMAYPALARPDSSVEP--FFDSVVKQLGIPDVFSLQMCGAGLSGSSAADPPGGSLIMGGAEPTLYRGSVWYTPIVEEWYYQVEVLKLEVDDQNLNL-DCKEYNMDKAIVDSGTTMLRLPAKVFNAVVEAITRSSLIQEFS----SGFWEGTKLACWMKG--ETPWRVFPKLSIYLRATNTSQSFRITILPQLYIQLITDENSAL----DCFRFGVSSSANGLVIGATVMEGFYVVFDRAHKRLGFALSSC 440
[Close]
BLAST of beta-secretase 1 vs. Ensembl Medaka
Match: nots (cathepsin D-like [Source:NCBI gene;Acc:101159061])

HSP 1 Score: 86.2705 bits (212), Expect = 1.173e-17
Identity = 95/378 (25.13%), Postives = 174/378 (46.03%), Query Frame = 1 
Query:  280 YYMTVGIGSPPQKFNLVIDTGSSNTAVAG----SPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPN-MFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPN---VIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGT------ILGDSFLEGFYFLFNKELSKVGIAQSK 1371
            YY  + +G+P Q F+++ DTGSS+  V      S       +FK+  SS++     + G+ Y SG   G+   D      +  ++    Q + + +         +  +TF      F G+LGLAYP LA+    I    +FD+++ +  L   +FS  L   +R++S+    G  + GG ++SLY+ P+  + +  K +++I +  +S+     + S C+     ++I+DTGT+    P    +  H L+ +               + F D       LS+ P+          + FV+ +   +E  L+S+ YI+      ++F +R  C+  GF  ++  +      ILGD FL  +Y +F+K   +VG A++K
Sbjct:   83 YYGEIRLGTPEQNFSVIFDTGSSDLWVPSSYCVSQACAFHRHFKAFKSSSFHHDGRTFGIHYGSGHLLGVMGKDTLRIGNLTVLN----QEFGESV--------YEPGSTFV--TAKFDGVLGLAYPSLAE----IIGKPVFDNMLAQKILDEPIFSFYL---SRSKSKSVPEGQLLLGGTDESLYSGPINWVPVTIKGYWQIRMDSVSVQG---VSSLCRRGC--EAIVDTGTSLIAGPPREILRLHQLIGA-------------TPTHFGDFVVDCARLSSLPH----------VTFVLGE---VEYTLTSEHYIRK-----ETFSSRELCFT-GFMAAEMFSADGPLWILGDVFLTQYYTIFDKGQDRVGFARAK 402
[Close]
BLAST of beta-secretase 1 vs. Ensembl Medaka
Match: ctsd (cathepsin D [Source:NCBI gene;Acc:111946846])

HSP 1 Score: 78.5666 bits (192), Expect = 3.284e-15
Identity = 100/393 (25.45%), Postives = 172/393 (43.77%), Query Frame = 1 
Query:  256 LKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAG------SPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGL-PNMFSVVLCGHNRN-ESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVIN-----DTSSLEVALSSQQYIQYVGDQI---DSFGNRRNCYKFGFGV---SKSGT--ILGDSFLEGFYFLFNKELSKVGIAQSK 1371
            LK   +  YY  + +G+PPQ F +V DTGSSN  V             L + + S  SSTYV +  S  + Y SG  +G  S D  T   ++     + Q + + I         +    F      F GILG+AYP ++    +     +FD+++ +  +  N+FS  L   NRN +++P   G  + GG +   Y+     + I R+ +++I +  +++ ++   LS CK     ++I+DTGT+    P+    +L                       ++A+  I            P IQ E++IN        ++   +  Q Y    GDQ    +S   +  C     G+   + +G   ILGD F+  +Y +F+++ ++VG A+SK
Sbjct:   68 LKNYLDAQYYGEIALGTPPQPFTVVFDTGSSNLWVPSVHCSLLDIACLLHHKYNSAKSSTYVKNGTSFSIQYGSGSLSGYLSQDTCTIGDISV----ENQVFGEAIK--------QPGVAFIA--AKFDGILGMAYPRISVDGVV----PVFDNIMQQKKVDSNVFSFYL---NRNPDTEP--GGELLLGGTDPKYYSGDFHYVNISRQAYWQIHMDGMAVGSQ---LSLCK--GGCEAIVDTGTSLLTGPSAEVKAL-----------------------QKAIGAI------------PLIQGEYMINCDKIPSLPAITFNIGGQSYT-LTGDQYVLKESQAGKTICLSGFMGLDIPAPAGPLWILGDVFIGQYYTVFDRDSNRVGFAKSK 396
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BLAST of beta-secretase 1 vs. Planmine SMEST
Match: SMESG000037819.1 (SMESG000037819.1)

HSP 1 Score: 968.763 bits (2503), Expect = 0.000e+0
Identity = 489/490 (99.80%), Postives = 490/490 (100.00%), Query Frame = 1 
Query:  145 MIPPQNIYPEESDFSLKGFNVAEKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLHVATVSRSRIIKVNRGQSGLLACAVRAGSKKSFLSQLTPXXXXXXXXXXXXXXXPSLVLMVYYRCAETKDPEQAALIQ 1614
            MIPPQNIYPEESDFSLKGFNVAEKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFS+VLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLHVATVSRSRIIKVNRGQSGLLACAVRAGSKKSFLSQLTPTLTIIIGVVFGVILIPSLVLMVYYRCAETKDPEQAALIQ
Sbjct:    1 MIPPQNIYPEESDFSLKGFNVAEKSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVVMKYGLPNMFSIVLCGHNRNESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPNHPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKFGFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLHVATVSRSRIIKVNRGQSGLLACAVRAGSKKSFLSQLTPTLTIIIGVVFGVILIPSLVLMVYYRCAETKDPEQAALIQ 490
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BLAST of beta-secretase 1 vs. Planmine SMEST
Match: SMESG000035344.1 (SMESG000035344.1)

HSP 1 Score: 61.6178 bits (148), Expect = 7.409e-10
Identity = 98/384 (25.52%), Postives = 161/384 (41.93%), Query Frame = 1 
Query:   67 IKQIQIYIFIFGILYSSGEIHSPLFRMIPPQNIYPEESDFSLKGFNVAEKS-VDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVAGSPQQFLSNY-------FKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVAYIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQPANLIHKSTLFDDVV-MKYGLPNMFSVVLCGHNRN-ESQPTTNGFFIAGGKNDSLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTGTADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICIL---SNSPNHPSTYFPEIQIEFVINDTSSLE 1179
            +K + I + I GI    G +  PL +M        E +  ++  FN+     + + I   I   L    +  Y+  + IG+PPQ F ++ DTGSSN  V  S +  L+N        + S  SSTYV +  +  + Y +G  +G  S+D         +    +Q + +         +++  TTF      F GILG+AYP ++    + H + +F ++V  K     +FS  L   NR+   +P   G  I GG + + Y  P     +  K +++  +  IS+  K    ++C       +I DTGT+    P  I   + S   FN         I      +  VI I     N P  PS Y  ++Q    ++  +SL 
Sbjct:    3 VKLLIIALVINGIF--GGLLRVPLKKM--------ESARSNIVKFNMMLNHFMKSEIKNPIPEPLDNYMDAQYFGEITIGTPPQPFTVLFDTGSSNLWVP-SKKCKLTNLACLTHRKYDSSKSSTYVKNGTAFSIRYGTGSLSGFLSTDTVIVATAKVV----SQTFGE--------AMVEPGTTFV--VAKFDGILGMAYPSIS----VDHVTPVFQNMVAQKLVDAPIFSFYL---NRDVNGKP--GGEIIFGGSDPNYYQGPFTYTPVTSKTYWQFSMQSISMLGK-TYCTNC------TAIADTGTSLIVGPQSIIDDINSK--FNGTKINGMTIILCSSVSKLPVINIQIAGRNFPLKPSDYILKLQDTVCVSGFTSLS 343
The following BLAST results are available for this feature:
BLAST of beta-secretase 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BACE15.821e-7436.65beta-secretase 1 [Source:HGNC Symbol;Acc:HGNC:933][more]
BACE11.704e-6434.55beta-secretase 1 [Source:HGNC Symbol;Acc:HGNC:933][more]
BACE11.063e-5932.98beta-secretase 1 [Source:HGNC Symbol;Acc:HGNC:933][more]
BACE21.112e-5833.76beta-secretase 2 [Source:HGNC Symbol;Acc:HGNC:934][more]
BACE13.317e-5334.20beta-secretase 1 [Source:HGNC Symbol;Acc:HGNC:933][more]
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BLAST of beta-secretase 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
asp-41.943e-1325.00ASpartyl Protease [Source:UniProtKB/TrEMBL;Acc:Q2... [more]
asp-12.614e-823.80ASpartyl Protease; Aspartic protease 1 [Source:Un... [more]
asp-12.614e-823.80ASpartyl Protease; Aspartic protease 1 [Source:Un... [more]
asp-121.260e-724.75ASpartyl Protease [Source:UniProtKB/TrEMBL;Acc:O0... [more]
asp-121.260e-724.75ASpartyl Protease [Source:UniProtKB/TrEMBL;Acc:O0... [more]
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BLAST of beta-secretase 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Bace8.413e-1426.67gene:FBgn0032049 transcript:FBtr0343427[more]
Bace8.413e-1426.67gene:FBgn0032049 transcript:FBtr0079701[more]
CG171343.718e-1327.60gene:FBgn0032304 transcript:FBtr0080140[more]
cathD1.335e-1026.51gene:FBgn0029093 transcript:FBtr0088898[more]
cathD1.335e-1026.51gene:FBgn0029093 transcript:FBtr0452079[more]
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BLAST of beta-secretase 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
bace22.053e-4332.79beta-secretase 2 [Source:ZFIN;Acc:ZDB-GENE-041010-... [more]
bace13.048e-2734.50beta-secretase 1 [Source:ZFIN;Acc:ZDB-GENE-040426-... [more]
bace21.804e-2241.18beta-secretase 2 [Source:ZFIN;Acc:ZDB-GENE-041010-... [more]
ctsd2.441e-1327.39cathepsin D [Source:ZFIN;Acc:ZDB-GENE-010131-8][more]
napsa5.606e-1324.48napsin A aspartic peptidase [Source:ZFIN;Acc:ZDB-G... [more]
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BLAST of beta-secretase 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
bace13.149e-6832.86beta-site APP-cleaving enzyme 1 [Source:NCBI gene;... [more]
bace13.777e-6832.86beta-site APP-cleaving enzyme 1 [Source:NCBI gene;... [more]
bace14.027e-6832.86beta-site APP-cleaving enzyme 1 [Source:NCBI gene;... [more]
bace14.333e-6832.86beta-site APP-cleaving enzyme 1 [Source:NCBI gene;... [more]
gast8.876e-5833.16gastrin [Source:Xenbase;Acc:XB-GENE-6458649][more]
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BLAST of beta-secretase 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Bace12.680e-7436.65beta-site APP cleaving enzyme 1 [Source:MGI Symbol... [more]
Bace14.210e-6032.98beta-site APP cleaving enzyme 1 [Source:MGI Symbol... [more]
Bace29.679e-5734.04beta-site APP-cleaving enzyme 2 [Source:MGI Symbol... [more]
Bace11.769e-4432.12beta-site APP cleaving enzyme 1 [Source:MGI Symbol... [more]
Ctsd4.437e-1526.49cathepsin D [Source:MGI Symbol;Acc:MGI:88562][more]
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BLAST of beta-secretase 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P56819|BACE1_RAT4.205e-7436.91Beta-secretase 1 OS=Rattus norvegicus OX=10116 GN=... [more]
sp|P56818|BACE1_MOUSE1.874e-7336.65Beta-secretase 1 OS=Mus musculus OX=10090 GN=Bace1... [more]
sp|Q2HJ40|BACE1_BOVIN2.464e-7336.65Beta-secretase 1 OS=Bos taurus OX=9913 GN=BACE1 PE... [more]
sp|P56817|BACE1_HUMAN2.796e-7336.65Beta-secretase 1 OS=Homo sapiens OX=9606 GN=BACE1 ... [more]
sp|Q1KLR6|BACE1_CAVPO5.350e-6334.29Beta-secretase 1 OS=Cavia porcellus OX=10141 GN=BA... [more]
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BLAST of beta-secretase 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1U7RGL73.071e-7235.80beta-secretase 1 OS=Mesocricetus auratus OX=10036 ... [more]
A0A4X2M7919.986e-7235.52Peptidase A1 domain-containing protein OS=Vombatus... [more]
M1VRQ81.740e-7135.39Beta-secretase 1 OS=Canis lupus familiaris OX=9615... [more]
A0A2K6KYQ51.925e-7135.37Beta-secretase 1 OS=Rhinopithecus bieti OX=61621 G... [more]
A0A2K5IHZ92.094e-7135.37Beta-secretase 1 OS=Colobus angolensis palliatus O... [more]
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BLAST of beta-secretase 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
bace14.810e-7034.55beta-secretase 1 [Source:NCBI gene;Acc:103025562][more]
bace14.810e-7034.55beta-secretase 1 [Source:NCBI gene;Acc:103025562][more]
bace14.157e-5631.41beta-secretase 1 [Source:NCBI gene;Acc:103025562][more]
bace27.888e-5131.22beta-secretase 2 [Source:ZFIN;Acc:ZDB-GENE-041010-... [more]
nots3.625e-1424.55cathepsin E-like [Source:NCBI gene;Acc:103036771][more]
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BLAST of beta-secretase 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSPMAT00000006274.12.118e-3137.95pep scaffold:Pmarinus_7.0:GL484715:1746:11685:1 ge... [more]
ENSPMAT00000001179.13.359e-936.76pep scaffold:Pmarinus_7.0:GL476699:589225:591292:-... [more]
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BLAST of beta-secretase 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
PEP46.959e-1025.00Vacuolar aspartyl protease (proteinase A); require... [more]
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BLAST of beta-secretase 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4
Match NameE-valueIdentityDescription
EDO393591.048e-5332.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374181.291e-1924.05Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO491621.978e-925.74Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO276802.288e-821.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of beta-secretase 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
bace11.038e-6734.82beta-secretase 1 [Source:NCBI gene;Acc:101160575][more]
bace22.763e-5531.03beta-secretase 2 [Source:NCBI gene;Acc:101167562][more]
bace23.894e-5531.03beta-secretase 2 [Source:NCBI gene;Acc:101167562][more]
nots1.173e-1725.13cathepsin D-like [Source:NCBI gene;Acc:101159061][more]
ctsd3.284e-1525.45cathepsin D [Source:NCBI gene;Acc:111946846][more]
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BLAST of beta-secretase 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000037819.10.000e+099.80SMESG000037819.1[more]
SMESG000035344.17.409e-1025.52SMESG000035344.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30016267 ID=SMED30016267|Name=beta-secretase 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1714bp
TTTTGAATTGATAATTTAATGGAAATACCGAATTTATGAAGAAATTTGAT
AATTAAATTTCCAATGATAAAACAAATACAGATTTATATTTTTATATTTG
GTATATTGTATAGTTCGGGAGAAATACATTCTCCTTTATTTCGAATGATT
CCGCCTCAGAATATTTATCCTGAAGAATCAGATTTTAGTTTAAAAGGATT
TAATGTTGCAGAAAAATCAGTTGATAATAGAATAATAACGTTAATAGAAA
CTGATTTAAAAGGAATATCTAATTATGGATATTATATGACAGTTGGAATT
GGTTCACCGCCACAAAAATTCAACCTCGTTATTGATACAGGCAGCAGCAA
CACTGCAGTCGCTGGATCTCCTCAGCAGTTTTTATCAAATTACTTCAAAT
CACAACTTTCTTCCACATACGTTGATCATAAAATCTCAGTCGGAGTTCCT
TATGACTCTGGCAAATGGAACGGTTTATATAGTTCCGATATTTTTACTTT
CGAAGGCGTAGCATACATAGATGCAAATAAAACACAAAGATATTCGAAGG
AAATTAACGTGAGATCTAATTTTGGCCTTATTAAAGAATCAACCACTTTC
TTCCCGAAAAATGGTAATTTTCAAGGAATATTGGGCCTGGCATATCCGGT
ATTGGCACAACCGGCAAATCTTATTCACAAATCAACATTGTTTGATGACG
TTGTGATGAAATACGGATTGCCGAATATGTTCTCCGTAGTGCTGTGTGGC
CATAACAGGAATGAATCTCAACCAACTACCAATGGATTCTTTATTGCCGG
AGGGAAAAATGATTCATTGTATAATCCACCATTGGTCGACATCCTTATAC
GTCGCAAATGGTTCTATGAAATAATTATAAGTCGCATTTCCATATCGAAC
AAGCCAATCATTTTATCCAGTTGTAAAGAGTACAACAGAGACAAATCAAT
ATTGGATACTGGAACTGCAGATACCTATTTTCCTAACGTAATATTCCATT
CTTTAGTGTCTTCAATCATATTTAATATGAAAAACGCTCCATTTAAAGTG
ACTATACATTCCCCTTTCTGGGACAGGCGAGCAGTAATCTGCATTTTATC
AAACAGTCCCAACCATCCTTCAACATATTTCCCTGAAATCCAGATTGAAT
TCGTTATTAATGACACATCGTCACTCGAAGTTGCTCTGTCATCTCAGCAA
TACATTCAATATGTTGGTGACCAAATCGATAGTTTTGGAAACAGGAGAAA
TTGTTACAAATTCGGATTTGGAGTTTCCAAATCCGGTACCATTCTTGGAG
ATTCGTTCTTGGAAGGATTTTACTTCTTATTCAATAAAGAGCTCAGTAAA
GTTGGAATAGCCCAGTCCAAATGTAACCTTCACGTAGCTACGGTTTCAAG
ATCTAGAATCATAAAAGTAAACAGAGGTCAATCCGGATTGTTGGCTTGTG
CAGTGCGAGCCGGTTCTAAGAAATCATTCTTAAGTCAATTAACACCCACT
CTTACAATCATAATTGGAGTTGTATTTGGGGTGATCCTTATTCCCAGCTT
GGTACTGATGGTCTATTATCGGTGCGCAGAAACCAAAGATCCTGAGCAGG
CTGCGCTCATCCAATAAATTGCTTTCAATTTTATAACATTCTGATTATCA
ATTTTGTCCATCAATAAGCGCTTTCAATTGATTTATTGGAATAAAAAATA
TTTTTTACAAAAAA
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protein sequence of SMED30016267-orf-1

>SMED30016267-orf-1 ID=SMED30016267-orf-1|Name=SMED30016267-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=518bp
MIKQIQIYIFIFGILYSSGEIHSPLFRMIPPQNIYPEESDFSLKGFNVAE
KSVDNRIITLIETDLKGISNYGYYMTVGIGSPPQKFNLVIDTGSSNTAVA
GSPQQFLSNYFKSQLSSTYVDHKISVGVPYDSGKWNGLYSSDIFTFEGVA
YIDANKTQRYSKEINVRSNFGLIKESTTFFPKNGNFQGILGLAYPVLAQP
ANLIHKSTLFDDVVMKYGLPNMFSVVLCGHNRNESQPTTNGFFIAGGKND
SLYNPPLVDILIRRKWFYEIIISRISISNKPIILSSCKEYNRDKSILDTG
TADTYFPNVIFHSLVSSIIFNMKNAPFKVTIHSPFWDRRAVICILSNSPN
HPSTYFPEIQIEFVINDTSSLEVALSSQQYIQYVGDQIDSFGNRRNCYKF
GFGVSKSGTILGDSFLEGFYFLFNKELSKVGIAQSKCNLHVATVSRSRII
KVNRGQSGLLACAVRAGSKKSFLSQLTPTLTIIIGVVFGVILIPSLVLMV
YYRCAETKDPEQAALIQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000035Category 3 cell
PLANA:0000043dorsal ventral margin of the whole animal
PLANA:0000070intestinal phagocyte
Vocabulary: INTERPRO
TermDefinition
IPR009121BACE2
IPR009119BACE
IPR001461Aspartic_peptidase_A1
IPR021109Peptidase_aspartic_dom_sf
IPR033121PEPTIDASE_A1
IPR001969Aspartic_peptidase_AS
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
GO:0006509membrane protein ectodomain proteolysis
GO:0030163protein catabolic process
GO:0050435beta-amyloid metabolic process
GO:0050804modulation of synaptic transmission
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0005768endosome
GO:0005770late endosome
GO:0005771multivesicular body
GO:0005783endoplasmic reticulum
GO:0005794Golgi apparatus
GO:0005802trans-Golgi network
GO:0005886plasma membrane
GO:0005887integral component of plasma membrane
GO:0009986cell surface
GO:0016020membrane
GO:0030424axon
GO:0030659cytoplasmic vesicle membrane
GO:0031410cytoplasmic vesicle
GO:0045121membrane raft
Vocabulary: molecular function
TermDefinition
GO:0004190aspartic-type endopeptidase activity
GO:0001540beta-amyloid binding
GO:0004175endopeptidase activity
GO:0008233peptidase activity
GO:0016787hydrolase activity
GO:0019899enzyme binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR009119Beta-secretase BACEPRINTSPR01815BACEFAMILYcoord: 97..119
score: 49.41
coord: 277..296
score: 42.05
coord: 370..384
score: 34.55
IPR001461Aspartic peptidase A1 familyPRINTSPR00792PEPSINcoord: 241..254
score: 28.07
coord: 79..99
score: 54.26
coord: 295..306
score: 40.29
coord: 409..424
score: 41.16
IPR001461Aspartic peptidase A1 familyPANTHERPTHR13683ASPARTYL PROTEASEScoord: 50..462
IPR033121Peptidase family A1 domainPFAMPF00026Aspcoord: 73..434
e-value: 4.5E-32
score: 111.7
IPR033121Peptidase family A1 domainPROSITEPS51767PEPTIDASE_A1coord: 73..433
score: 36.21
IPR021109Aspartic peptidase domain superfamilyGENE3DG3DSA:2.40.70.10coord: 73..216
e-value: 4.6E-29
score: 103.3
IPR021109Aspartic peptidase domain superfamilyGENE3DG3DSA:2.40.70.10coord: 220..462
e-value: 4.9E-47
score: 161.9
IPR021109Aspartic peptidase domain superfamilySUPERFAMILYSSF50630Acid proteasescoord: 65..438
IPR009121Beta-secretase BACE2PANTHERPTHR13683:SF262BETA-SECRETASE 2coord: 50..462
IPR001969Aspartic peptidase, active sitePROSITEPS00141ASP_PROTEASEcoord: 88..99
NoneNo IPR availableTMHMMTMhelixcoord: 480..502
NoneNo IPR availableTMHMMTMhelixcoord: 7..26