Saposin

Overview


Name	Saposin
Smed ID	SMED30016252
Length (bp)	1115

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Saposin (SMED30016252) t-SNE clustered cells

Violin plots show distribution of expression levels for Saposin (SMED30016252) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Saposin (SMED30016252) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Saposin (SMED30016252) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30016252

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30016252	SMESG000074184.1 SMESG000019975.1	dd_Smed_v4_266_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30016252	SMESG000074184.1 SMESG000019975.1	dd_Smed_v4_266_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30016252	SMESG000074184.1 SMESG000019975.1	dd_Smed_v4_266_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30016252	SMESG000074184.1 SMESG000019975.1	dd_Smed_v4_266_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30016252	SMESG000074184.1 SMESG000019975.1	dd_Smed_v4_266_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30016252	SMESG000074184.1 SMESG000019975.1	dd_Smed_v4_266_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30016252	SMESG000019975.1	Contig48675	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30016252	SMESG000019975.1	Contig48675	newmark_ests	PMID:29674431 Fincher et al., 2018
epidermis	SMED30016252	SMESG000074184.1 SMESG000019975.1	dd_Smed_v6_266_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
parenchymal cell	SMED30016252	SMESG000074184.1 SMESG000019975.1	dd_Smed_v6_266_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
epidermis	SMED30016252	SMESG000074184.1 SMESG000019975.1	dd_Smed_v4_266_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Saposin vs. Ensembl Human
Match: PSAP (prosaposin [Source:HGNC Symbol;Acc:HGNC:9498])

HSP 1 Score: 76.6406 bits (187), Expect = 1.255e-14
Identity = 39/184 (21.20%), Postives = 95/184 (51.63%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS------LAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMY 929
            C+VC+ L+++V   I +N ++  +    +K+C  LP      C+++VD +  +I+  +++ +  + +C  + LCS          ++ P++    C +C +++  + + + +    +EI  ALE  C+  P  Y+ QC++FV  Y   ++++++E      +C  +  C + + P + ++  ++
Sbjct:  318 CEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGG-FCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIW 500

HSP 2 Score: 61.2326 bits (147), Expect = 1.249e-9
Identity = 48/204 (23.53%), Postives = 90/204 (44.12%), Query Frame = 3

Query:  399 DVCKKLIQQVID---AIGSNHS-KDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVK-NLPADK-ICQNIGLCS----------------------SLAAISP------PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTI 908
            DVC+  IQ V D   A+ +N +    + + +++ CD L      +CK+ + ++++  +  ++  +L   K IC  +G C                       +L  + P      P +  V C +C  +++E+ K I   +  +EI  A + +C+  P     +C E VD Y   I+ ++LE  +  ++CS L LC     P +
Sbjct:  196 DVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMSLQQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPAL 399

[Close]

BLAST of Saposin vs. Ensembl Human
Match: PSAP (prosaposin [Source:HGNC Symbol;Acc:HGNC:9498])

HSP 1 Score: 76.6406 bits (187), Expect = 1.418e-14
Identity = 39/184 (21.20%), Postives = 95/184 (51.63%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS------LAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMY 929
            C+VC+ L+++V   I +N ++  +    +K+C  LP      C+++VD +  +I+  +++ +  + +C  + LCS          ++ P++    C +C +++  + + + +    +EI  ALE  C+  P  Y+ QC++FV  Y   ++++++E      +C  +  C + + P + ++  ++
Sbjct:  315 CEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGG-FCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIW 497

HSP 2 Score: 65.0846 bits (157), Expect = 7.402e-11
Identity = 47/202 (23.27%), Postives = 91/202 (45.05%), Query Frame = 3

Query:  399 DVCKKLIQQVID---AIGSNHS-KDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCS----------------------SLAAISP------PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTI 908
            DVC+  IQ V D   A+ +N +    + + +++ CD L      +CK+ + ++++ I  +++ ++   +IC  +G C                       +L  + P      P +  V C +C  +++E+ K I   +  +EI  A + +C+  P     +C E VD Y   I+ ++LE  +  ++CS L LC     P +
Sbjct:  196 DVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSE-IAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPAL 396

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BLAST of Saposin vs. Ensembl Human
Match: PSAPL1 (prosaposin like 1 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:33131])

HSP 1 Score: 64.3142 bits (155), Expect = 1.379e-10
Identity = 52/227 (22.91%), Postives = 99/227 (43.61%), Query Frame = 3

Query:  306 PTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS---------LAAISPPRE-----KSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKF 944
            P+  +G+   +   Q+K  +T         C+VC  ++Q++   + SN S+ ++   LE+VC  +P      C  +VD ++ ++V  + K  P +K+C+ I LC +           AI P  E     +   C  C +++      +  +    +I  A +G C+I P+ Y  QC  FV +Y   +++ + +      +C  +  C     P + + D     P F
Sbjct:  273 PSLELGLPRKQSEMQMKAGVT---------CEVCMNVVQKLDHWLMSNSSELMITHALERVCSVMPASITKECIILVDTYSPSLVQLVAKITP-EKVCKFIRLCGNRRRARAVHDAYAIVPSPEWDAENQGSFCNGCKRLLTVSSHNLESKSTKRDILVAFKGGCSILPLPYMIQCKHFVTQYEPVLIESLKDMMDPVAVCKKVGACHGPRTPLLGT-DQCALGPSF 488

[Close]

BLAST of Saposin vs. Ensembl Human
Match: PSAP (prosaposin [Source:HGNC Symbol;Acc:HGNC:9498])

HSP 1 Score: 51.9878 bits (123), Expect = 4.215e-7
Identity = 30/150 (20.00%), Postives = 70/150 (46.67%), Query Frame = 3

Query:  519 VCKDIVDKFADTIVDEIVKN-------LPADKICQNIGLCSSL------AAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMY 929
            +CKD+V    D + D   +        +  + +C  + LCS          ++ P++    C +C +++  + + + +    +EI  ALE  C+  P  Y+ QC++FV  Y   ++++++E      +C  +  C + + P + ++  ++
Sbjct:   65 ICKDVVTAAGDMLKDNATEEEILVYLEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGG-FCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIW 213

[Close]

BLAST of Saposin vs. Ensembl Fly
Match: Sap-r (gene:FBgn0000416 transcript:FBtr0085714)

HSP 1 Score: 86.2705 bits (212), Expect = 5.570e-18
Identity = 52/186 (27.96%), Postives = 91/186 (48.92%), Query Frame = 3

Query:  393 GCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-------------SSLAAISPPREKSVL---------CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
             C +C++L++ +   +G + ++D ++  LE+ CD +       C  ++DK+ D I D ++K +    IC  +G+C                  I+ PR+ + L         C +C  I+ ++   +  +   ++IKRA+E VCN  P   R QC+ FVD YA  ++KL+ +     V C  LQLC
Sbjct:  588 NCLICEELVKTLEKRMGKHPTRDSIKHILEESCDRMRKPMNTKCHKVIDKYGDKIADLLLKEMDPKLICTELGMCILADLDDLEVDEALKYDVIALPRQDNKLSSSIKEPPTCVLCEFIMTKLDADLKNKTEQDDIKRAIEAVCNRLPATVRKQCDTFVDGYASAVLKLLSDVPPKQV-CQKLQLC 772

HSP 2 Score: 65.0846 bits (157), Expect = 4.002e-11
Identity = 36/179 (20.11%), Postives = 84/179 (46.93%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-------SSLAAISP----PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNY 899
            C +C+ ++  + + + +  + D ++  +E +C  LP      C++ V+ + D ++  +V+ L    +C  + +C         +   +P      +    C +C   +E+   +I + +  + IK+ L G+C+  P   + +C +FV+ Y+ E++ +++       IC  L+LC    Y
Sbjct:  360 CTLCEYMLHFIQETLATPSTDDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKKEDVEVFNPQPASDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYSNELIDMLITDFKPQEICVQLKLCPKTTY 538

HSP 3 Score: 65.0846 bits (157), Expect = 4.453e-11
Identity = 50/211 (23.70%), Postives = 91/211 (43.13%), Query Frame = 3

Query:  372 SEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-----------------------SSLAAIS----------PPR-------EKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            S+E     C +C   ++Q    I  N SKD ++K L  +C  LP   K  C D V+ +++ ++D ++ +    +IC  + LC                       SS   IS          PP+         +  C IC ++++ + K++G+    + IK  LE  C+        +C++ +D+Y  +I  L+L+     +IC+ L +C
Sbjct:  452 SDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYSNELIDMLITDFKPQEICVQLKLCPKTTYALWDLRISLEDDVDGEDKSSSEEISFNDIESLEELPPQLAFDPGFTAAPNCLICEELVKTLEKRMGKHPTRDSIKHILEESCDRMRKPMNTKCHKVIDKYGDKIADLLLKEMDPKLICTELGMC 662

HSP 4 Score: 50.0618 bits (118), Expect = 2.774e-6
Identity = 40/195 (20.51%), Postives = 78/195 (40.00%), Query Frame = 3

Query:  390 FGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSL------------AAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLP 938
              C  C  L + +     +    D+V   L  +C  L   +   C +IV  + + I D + K+L  D +C   G+C+S             A ++      + C +C Q+++ +   +       E K+ +EG C      ++ +C   VD+Y   I + ++        C  + +C+  +  ++K    M  LP
Sbjct:  109 LSCGNCNLLSRLMHSKFAATDRDDMVETMLH-MCGSLS-SFSDACANIVLTYFNDIYDHVSKHLTTDAVCHVSGVCASRYHQHEEEKQPQEALVALDAGDDIPCELCEQLVKHLRDVLVANTTETEFKQVMEGFCKQSKG-FKDECLSIVDQYYHVIYETLVSKLDANGACCMIGICQKNSASSMKDVPIMPLLP 300

HSP 5 Score: 49.6766 bits (117), Expect = 3.801e-6
Identity = 28/100 (28.00%), Postives = 48/100 (48.00%), Query Frame = 3

Query:  648 EKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKFA 947
            E   LC +C  ++  I + +      +EIK  +E +C   P     QC  FV+ Y   ++ L+++G     +C  +Q+C  +N P  K +D   F P+ A
Sbjct:  355 EGGELCTLCEYMLHFIQETLATPSTDDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMC-PKNLP--KKEDVEVFNPQPA 451

[Close]

BLAST of Saposin vs. Ensembl Fly
Match: Sap-r (gene:FBgn0000416 transcript:FBtr0085713)

HSP 1 Score: 85.8853 bits (211), Expect = 6.973e-18
Identity = 52/186 (27.96%), Postives = 91/186 (48.92%), Query Frame = 3

Query:  393 GCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-------------SSLAAISPPREKSVL---------CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
             C +C++L++ +   +G + ++D ++  LE+ CD +       C  ++DK+ D I D ++K +    IC  +G+C                  I+ PR+ + L         C +C  I+ ++   +  +   ++IKRA+E VCN  P   R QC+ FVD YA  ++KL+ +     V C  LQLC
Sbjct:  665 NCLICEELVKTLEKRMGKHPTRDSIKHILEESCDRMRKPMNTKCHKVIDKYGDKIADLLLKEMDPKLICTELGMCILADLDDLEVDEALKYDVIALPRQDNKLSSSIKEPPTCVLCEFIMTKLDADLKNKTEQDDIKRAIEAVCNRLPATVRKQCDTFVDGYASAVLKLLSDVPPKQV-CQKLQLC 849

HSP 2 Score: 65.4698 bits (158), Expect = 3.897e-11
Identity = 36/179 (20.11%), Postives = 84/179 (46.93%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-------SSLAAISP----PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNY 899
            C +C+ ++  + + + +  + D ++  +E +C  LP      C++ V+ + D ++  +V+ L    +C  + +C         +   +P      +    C +C   +E+   +I + +  + IK+ L G+C+  P   + +C +FV+ Y+ E++ +++       IC  L+LC    Y
Sbjct:  437 CTLCEYMLHFIQETLATPSTDDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKKEDVEVFNPQPASDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYSNELIDMLITDFKPQEICVQLKLCPKTTY 615

HSP 3 Score: 65.0846 bits (157), Expect = 5.179e-11
Identity = 50/211 (23.70%), Postives = 91/211 (43.13%), Query Frame = 3

Query:  372 SEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-----------------------SSLAAIS----------PPR-------EKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            S+E     C +C   ++Q    I  N SKD ++K L  +C  LP   K  C D V+ +++ ++D ++ +    +IC  + LC                       SS   IS          PP+         +  C IC ++++ + K++G+    + IK  LE  C+        +C++ +D+Y  +I  L+L+     +IC+ L +C
Sbjct:  529 SDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYSNELIDMLITDFKPQEICVQLKLCPKTTYALWDLRISLEDDVDGEDKSSSEEISFNDIESLEELPPQLAFDPGFTAAPNCLICEELVKTLEKRMGKHPTRDSIKHILEESCDRMRKPMNTKCHKVIDKYGDKIADLLLKEMDPKLICTELGMC 739

HSP 4 Score: 50.447 bits (119), Expect = 2.235e-6
Identity = 40/195 (20.51%), Postives = 78/195 (40.00%), Query Frame = 3

Query:  390 FGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSL------------AAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLP 938
              C  C  L + +     +    D+V   L  +C  L   +   C +IV  + + I D + K+L  D +C   G+C+S             A ++      + C +C Q+++ +   +       E K+ +EG C      ++ +C   VD+Y   I + ++        C  + +C+  +  ++K    M  LP
Sbjct:  186 LSCGNCNLLSRLMHSKFAATDRDDMVETMLH-MCGSLS-SFSDACANIVLTYFNDIYDHVSKHLTTDAVCHVSGVCASRYHQHEEEKQPQEALVALDAGDDIPCELCEQLVKHLRDVLVANTTETEFKQVMEGFCKQSKG-FKDECLSIVDQYYHVIYETLVSKLDANGACCMIGICQKNSASSMKDVPIMPLLP 377

HSP 5 Score: 49.6766 bits (117), Expect = 4.084e-6
Identity = 28/100 (28.00%), Postives = 48/100 (48.00%), Query Frame = 3

Query:  648 EKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKFA 947
            E   LC +C  ++  I + +      +EIK  +E +C   P     QC  FV+ Y   ++ L+++G     +C  +Q+C  +N P  K +D   F P+ A
Sbjct:  432 EGGELCTLCEYMLHFIQETLATPSTDDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMC-PKNLP--KKEDVEVFNPQPA 528

[Close]

BLAST of Saposin vs. Ensembl Zebrafish
Match: sftpbb (surfactant protein Bb [Source:NCBI gene;Acc:100001978])

HSP 1 Score: 65.4698 bits (158), Expect = 1.732e-11
Identity = 48/204 (23.53%), Postives = 84/204 (41.18%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPA-----DKICQNIGLCSSLAAISPPREKSV----------------------------LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTI 908
            C  C K++Q + + +    S+ ++ K +++ CD  P +  P+C D     A T V  I+++  A       +C  +GLC    A+ P R+ +                             +C  C   I+ +   + + +    I+  LE +C   P  Y   CN FV  YA ++++L+L       IC+AL LC     P +
Sbjct:   40 CSDCNKIVQLLTEMLSHPDSQHLIEKAVDRFCDEHPVI--PLCMD----GAKTYVHLIIRHFSAFTKENGDVCSMLGLC----AVQPERKSASELDFSLNEQGLIYTKPSRGTGPEVRINPICNFCLLFIKTVESLLPKEKTEAAIEELLEKICGYLPEHYEDTCNTFVKTYAKQLIELLLYSMPPHAICTALGLCLLPETPAM 233

[Close]

BLAST of Saposin vs. Ensembl Zebrafish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 62.7734 bits (151), Expect = 2.583e-10
Identity = 33/144 (22.92%), Postives = 73/144 (50.69%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREK-----SVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRY 812
            C +C+ +++++ + I    S+  + + +EKVC+ LP      CKD+++ +   I+D +V+      +C  + LCS ++ + P  +K        C +C   +  +   + +     EI+ A+  VC+  P   + +CN+ +++Y
Sbjct:  312 CAICEYVMKEIENMIQDQTSEAEIVQAVEKVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALCSGVSHV-PVMDKQHFAAGGFCDVCKMAVRYVDGILEQNATQSEIEEAVLKVCSFLPDAVKDECNQLIEQY 454

HSP 2 Score: 55.0694 bits (131), Expect = 7.116e-8
Identity = 49/209 (23.44%), Postives = 81/209 (38.76%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSK-DVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS----------LAAISPPREK------------------------SVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSK 917
            C  C   I    D    N S    +  ++E  C+ L      +CK+ + ++   +  +++   P D IC   G C +          L A S P  K                        S  C IC  +++EI   I ++    EI +A+E VCNI P     QC + ++ Y   I+ L+++      +CS L LC   ++  +  K
Sbjct:  189 CQDCVTFINDTQDEARVNSSFISTLIAQVENQCELLGPGMSDMCKEYISQYGPLVFQQLMSMQPKD-ICARAGFCPTKQKSVPMEKLLPAKSIPAVKMFPAVKVEKPVATMPAKNLVRVRDSPQCAICEYVMKEIENMIQDQTSEAEIVQAVEKVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALCSGVSHVPVMDK 396

[Close]

BLAST of Saposin vs. Ensembl Zebrafish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 62.7734 bits (151), Expect = 2.636e-10
Identity = 33/144 (22.92%), Postives = 73/144 (50.69%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREK-----SVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRY 812
            C +C+ +++++ + I    S+  + + +EKVC+ LP      CKD+++ +   I+D +V+      +C  + LCS ++ + P  +K        C +C   +  +   + +     EI+ A+  VC+  P   + +CN+ +++Y
Sbjct:  314 CAICEYVMKEIENMIQDQTSEAEIVQAVEKVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALCSGVSHV-PVMDKQHFAAGGFCDVCKMAVRYVDGILEQNATQSEIEEAVLKVCSFLPDAVKDECNQLIEQY 456

HSP 2 Score: 52.373 bits (124), Expect = 5.899e-7
Identity = 26/85 (30.59%), Postives = 44/85 (51.76%), Query Frame = 3

Query:  663 CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSK 917
            C IC  +++EI   I ++    EI +A+E VCNI P     QC + ++ Y   I+ L+++      +CS L LC   ++  +  K
Sbjct:  314 CAICEYVMKEIENMIQDQTSEAEIVQAVEKVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALCSGVSHVPVMDK 398

[Close]

BLAST of Saposin vs. Ensembl Zebrafish
Match: sftpba (surfactant protein Ba [Source:ZFIN;Acc:ZDB-GENE-091204-378])

HSP 1 Score: 55.0694 bits (131), Expect = 2.748e-8
Identity = 34/117 (29.06%), Postives = 52/117 (44.44%), Query Frame = 3

Query:  588 DKICQNIGLCS---------------SLAAISPPR--EKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCE 887
             +IC  +GLC                S     PP   E SV C +C+ I+  +     + R    I   LE +C  FP + + QCN+ V +Y   +V ++L   +   IC+ L+LCE
Sbjct:    4 SEICTYLGLCGGRDSGKIKDLLLNHMSKTGTMPPMQMESSVQCSVCTYIVSTLGFLFPKERTQNIITVLLESLCKEFPPLVQPQCNKLVGKYVQMLVDMLLNNTSPNFICTLLRLCE 120

HSP 2 Score: 50.8322 bits (120), Expect = 7.396e-7
Identity = 43/207 (20.77%), Postives = 85/207 (41.06%), Query Frame = 3

Query:  342 HAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSVL----CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGV-ICSALQLCETRNYPTIKSKDTMYFLPKFA 947
            H      M   +   S  C VC  ++  +        +++++   LE +C   P + +P C  +V K+   +VD ++ N   + IC  + LC     IS  R+ + L    C  C  +       +G      +    L+ VC + P     +C  +++R   ++  L L  + G +  C +  LC + +  ++ + D     PK++
Sbjct:   28 HMSKTGTMPPMQMESSVQCSVCTYIVSTLGFLFPKERTQNIITVLLESLCKEFPPLVQPQCNKLVGKYVQMLVDMLLNNTSPNFICTLLRLCE----IS-ERQINTLALSNCDSCLTLAVLTQMHLGSNATEHQAASFLDSVCQLNPNAMP-KCETYIERNGKQL-SLFLSKQQGALDTCKSANLCPSDDKESVITADPCSLGPKYS 227

[Close]

BLAST of Saposin vs. Ensembl Zebrafish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 53.1434 bits (126), Expect = 8.865e-8
Identity = 26/85 (30.59%), Postives = 44/85 (51.76%), Query Frame = 3

Query:  663 CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSK 917
            C IC  +++EI   I ++    EI +A+E VCNI P     QC + ++ Y   I+ L+++      +CS L LC   ++  +  K
Sbjct:   74 CAICEYVMKEIENMIQDQTSEAEIVQAVEKVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALCSGVSHVPVMDK 158

HSP 2 Score: 52.373 bits (124), Expect = 1.485e-7
Identity = 30/130 (23.08%), Postives = 64/130 (49.23%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSV-----LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFP 770
            C +C+ +++++ + I    S+  + + +EKVC+ LP      CKD+++ +   I+D +V+      +C  + LCS ++ + P  +K        C +C   +  +   + +     EI+ A+  VC+  P
Sbjct:   74 CAICEYVMKEIENMIQDQTSEAEIVQAVEKVCNILPSTLTAQCKDLIETYGQAIIDLLVQEADPKTVCSFLALCSGVSHV-PVMDKQHFAAGGFCDVCKMAVRYVDGILEQNATQSEIEEAVLKVCSFLP 202

[Close]

BLAST of Saposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 85.1149 bits (209), Expect = 1.784e-17
Identity = 54/202 (26.73%), Postives = 101/202 (50.00%), Query Frame = 3

Query:  306 PTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS----LAAISPPREKSV---LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            P K + I   ++   +KI       N  F C+VC+ +I Q+   + +N +K+ ++  LEKVC  LP  +   C+DI++++ D +++ + +      IC  +G CS+    L  +    EK+     C +C  +++ + + + +      IK  L  VCN  P   + +C+  V++Y    V+L+LE      IC+ L LC++
Sbjct:  247 PAKTL-IPAAKVQPAVKITENPLAGNGVF-CEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSARRKNLQNVKISAEKAAAGDYCTVCKMMMKYVDELLEKNATEIRIKNFLSRVCNFLPDSMQDECSGLVNQYEPLFVQLLLEALDPSFICAKLHLCQS 446

HSP 2 Score: 72.0182 bits (175), Expect = 3.026e-13
Identity = 50/193 (25.91%), Postives = 87/193 (45.08%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSN--HSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-----SSLAAISPPRE--------------------KSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            C+ C KL+  V DA+ SN   SK++V   L + C+ L      +CK  +++F+D  +  +++  P  ++C  +G C     + L  I P +                       V C +C  +I +I K +   R  E IK +LE VC + P  Y  +C + ++ Y   +++L+ +      IC+ L  C  R
Sbjct:  161 CNDCLKLVSDVQDALRSNASFSKNLVDHALHE-CELLDPGMAEMCKSYINQFSDVAIQVLLQMQPK-QLCSMVGFCDQEKSTPLQNIIPAKTLIPAAKVQPAVKITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSAR 351

[Close]

BLAST of Saposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 84.7297 bits (208), Expect = 1.830e-17
Identity = 59/226 (26.11%), Postives = 111/226 (49.12%), Query Frame = 3

Query:  243 EKKLLCTLFPETFREKCSEYS---PTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS----LAAISPPREKSV---LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            + K LC++     +EK +      P K + I   ++   +KI       N  F C+VC+ +I Q+   + +N +K+ ++  LEKVC  LP  +   C+DI++++ D +++ + +      IC  +G CS+    L  +    EK+     C +C  +++ + + + +      IK  L  VCN  P   + +C+  V++Y    V+L+LE      IC+ L LC++
Sbjct:  199 QPKQLCSMVGFCDQEKSTPLQNIIPAKTL-IPAAKVQPAVKITENPLAGNGVF-CEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSARRKNLQNVKISAEKAAAGDYCTVCKMMMKYVDELLEKNATEIRIKNFLSRVCNFLPDSMQDECSGLVNQYEPLFVQLLLEALDPSFICAKLHLCQS 422

HSP 2 Score: 71.633 bits (174), Expect = 3.914e-13
Identity = 50/193 (25.91%), Postives = 87/193 (45.08%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSN--HSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-----SSLAAISPPRE--------------------KSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            C+ C KL+  V DA+ SN   SK++V   L + C+ L      +CK  +++F+D  +  +++  P  ++C  +G C     + L  I P +                       V C +C  +I +I K +   R  E IK +LE VC + P  Y  +C + ++ Y   +++L+ +      IC+ L  C  R
Sbjct:  137 CNDCLKLVSDVQDALRSNASFSKNLVDHALHE-CELLDPGMAEMCKSYINQFSDVAIQVLLQMQPK-QLCSMVGFCDQEKSTPLQNIIPAKTLIPAAKVQPAVKITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSAR 327

[Close]

BLAST of Saposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 84.7297 bits (208), Expect = 2.739e-17
Identity = 54/202 (26.73%), Postives = 101/202 (50.00%), Query Frame = 3

Query:  306 PTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS----LAAISPPREKSV---LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            P K + I   ++   +KI       N  F C+VC+ +I Q+   + +N +K+ ++  LEKVC  LP  +   C+DI++++ D +++ + +      IC  +G CS+    L  +    EK+     C +C  +++ + + + +      IK  L  VCN  P   + +C+  V++Y    V+L+LE      IC+ L LC++
Sbjct:  226 PAKTL-IPAAKVQPAVKITENPLAGNGVF-CEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSARRKNLQNVKISAEKAAAGDYCTVCKMMMKYVDELLEKNATEIRIKNFLSRVCNFLPDSMQDECSGLVNQYEPLFVQLLLEALDPSFICAKLHLCQS 425

HSP 2 Score: 71.2478 bits (173), Expect = 6.651e-13
Identity = 50/193 (25.91%), Postives = 87/193 (45.08%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSN--HSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-----SSLAAISPPRE--------------------KSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            C+ C KL+  V DA+ SN   SK++V   L + C+ L      +CK  +++F+D  +  +++  P  ++C  +G C     + L  I P +                       V C +C  +I +I K +   R  E IK +LE VC + P  Y  +C + ++ Y   +++L+ +      IC+ L  C  R
Sbjct:  140 CNDCLKLVSDVQDALRSNASFSKNLVDHALHE-CELLDPGMAEMCKSYINQFSDVAIQVLLQMQPK-QLCSMVGFCDQEKSTPLQNIIPAKTLIPAAKVQPAVKITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSAR 330

[Close]

BLAST of Saposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 83.9593 bits (206), Expect = 4.083e-17
Identity = 47/172 (27.33%), Postives = 90/172 (52.33%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS----LAAISPPREKSV---LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C+VC+ +I Q+   + +N +K+ ++  LEKVC  LP  +   C+DI++++ D +++ + +      IC  +G CS+    L  +    EK+     C +C  +++ + + + +      IK  L  VCN  P   + +C+  V++Y    V+L+LE      IC+ L LC++
Sbjct:  266 CEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSARRKNLQNVKISAEKAAAGDYCTVCKMMMKYVDELLEKNATEIRIKNFLSRVCNFLPDSMQDECSGLVNQYEPLFVQLLLEALDPSFICAKLHLCQS 437

HSP 2 Score: 73.9442 bits (180), Expect = 9.905e-14
Identity = 50/187 (26.74%), Postives = 87/187 (46.52%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSN--HSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-----SSLAAISPPRE--------------KSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            C+ C KL+  V DA+ SN   SK++V   L + C+ L      +CK  +++F+D  +  +++  P  ++C  +G C     + L  I P +                 V C +C  +I +I K +   R  E IK +LE VC + P  Y  +C + ++ Y   +++L+ +      IC+ L  C  R
Sbjct:  158 CNDCLKLVSDVQDALRSNASFSKNLVDHALHE-CELLDPGMAEMCKSYINQFSDVAIQVLLQMQPK-QLCSMVGFCDQEKSTPLQNIIPAKTLIPAAKITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSAR 342

[Close]

BLAST of Saposin vs. Ensembl Xenopus
Match: psap (prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) [Source:NCBI gene;Acc:550039])

HSP 1 Score: 80.1073 bits (196), Expect = 7.678e-16
Identity = 47/181 (25.97%), Postives = 90/181 (49.72%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS---------------LAAISPPREKSV-LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C+VC+ +I Q+   + +N +K+ ++  LEKVC  LP  +   C+DI++++ D +++ + +      IC  +G CS+               L  IS  +  +   C +C  +++ + + + +      IK  L  VCN  P   + +C+  V++Y    V+L+LE      IC+ L LC++
Sbjct:  267 CEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSARRKNLQNGNMLRGIPLLKISAEKAAAGDYCTVCKMMMKYVDELLEKNATEIRIKNFLSRVCNFLPDSMQDECSGLVNQYEPLFVQLLLEALDPSFICAKLHLCQS 447

HSP 2 Score: 74.3294 bits (181), Expect = 5.891e-14
Identity = 50/187 (26.74%), Postives = 87/187 (46.52%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSN--HSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-----SSLAAISPPRE--------------KSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            C+ C KL+  V DA+ SN   SK++V   L + C+ L      +CK  +++F+D  +  +++  P  ++C  +G C     + L  I P +                 V C +C  +I +I K +   R  E IK +LE VC + P  Y  +C + ++ Y   +++L+ +      IC+ L  C  R
Sbjct:  159 CNDCLKLVSDVQDALRSNASFSKNLVDHALHE-CELLDPGMAEMCKSYINQFSDVAIQVLLQMQPK-QLCSMVGFCDQEKSTPLQNIIPAKTLIPAAKITENPLAGNGVFCEVCQLMISQIEKLLDNNRTKENIKHSLEKVCKLLPAEYSQKCEDIIEEYYDPLIELLEQEANPQFICTTLGYCSAR 343

[Close]

BLAST of Saposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 70.8626 bits (172), Expect = 6.539e-13
Identity = 44/201 (21.89%), Postives = 89/201 (44.28%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC------------------------------------SSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C  C+ ++ +  + I +N +++++ K L   C  LP   +  C+++V  F  +++D  +  +    +C  IGLC                                    S+L A  PP++    C +C +++  +   + +    EEI  ALE  C+  P  Y+ QC++FV  Y   ++++++E    G +CS + +C +
Sbjct:  311 CQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPAHVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 511

[Close]

BLAST of Saposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 70.8626 bits (172), Expect = 6.930e-13
Identity = 44/201 (21.89%), Postives = 89/201 (44.28%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC------------------------------------SSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C  C+ ++ +  + I +N +++++ K L   C  LP   +  C+++V  F  +++D  +  +    +C  IGLC                                    S+L A  PP++    C +C +++  +   + +    EEI  ALE  C+  P  Y+ QC++FV  Y   ++++++E    G +CS + +C +
Sbjct:  314 CQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPAHVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 514

[Close]

BLAST of Saposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 70.8626 bits (172), Expect = 7.203e-13
Identity = 44/201 (21.89%), Postives = 89/201 (44.28%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC------------------------------------SSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C  C+ ++ +  + I +N +++++ K L   C  LP   +  C+++V  F  +++D  +  +    +C  IGLC                                    S+L A  PP++    C +C +++  +   + +    EEI  ALE  C+  P  Y+ QC++FV  Y   ++++++E    G +CS + +C +
Sbjct:  316 CQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPAHVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 516

[Close]

BLAST of Saposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 70.8626 bits (172), Expect = 7.343e-13
Identity = 44/201 (21.89%), Postives = 89/201 (44.28%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC------------------------------------SSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C  C+ ++ +  + I +N +++++ K L   C  LP   +  C+++V  F  +++D  +  +    +C  IGLC                                    S+L A  PP++    C +C +++  +   + +    EEI  ALE  C+  P  Y+ QC++FV  Y   ++++++E    G +CS + +C +
Sbjct:  317 CQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPAHVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 517

[Close]

BLAST of Saposin vs. Ensembl Mouse
Match: Psap (prosaposin [Source:MGI Symbol;Acc:MGI:97783])

HSP 1 Score: 70.8626 bits (172), Expect = 7.612e-13
Identity = 44/201 (21.89%), Postives = 89/201 (44.28%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC------------------------------------SSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C  C+ ++ +  + I +N +++++ K L   C  LP   +  C+++V  F  +++D  +  +    +C  IGLC                                    S+L A  PP++    C +C +++  +   + +    EEI  ALE  C+  P  Y+ QC++FV  Y   ++++++E    G +CS + +C +
Sbjct:  317 CQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPAHVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 517

[Close]

BLAST of Saposin vs. UniProt/SwissProt
Match: sp|P26779|SAP_BOVIN (Prosaposin OS=Bos taurus OX=9913 GN=PSAP PE=1 SV=3)

HSP 1 Score: 83.9593 bits (206), Expect = 2.187e-16
Identity = 43/183 (23.50%), Postives = 94/183 (51.37%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISP-----PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMY 929
            C+VC+ ++++V   I +N +++ +   L+KVC  LP      C+++VD +  +I+  ++     + +C  + LCSS    +      PR+    C +C +++  + + + +    E+I  ALE  C+  P  YR QC++FV  Y   ++++++E      +C  +  C   + P + ++  ++
Sbjct:  316 CEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGSSILSILLDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGGFCEVCKKLVGYLDRNLEKNSTKEQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPAAHKPLLGAEKCVW 498

HSP 2 Score: 73.9442 bits (180), Expect = 4.449e-13
Identity = 48/199 (24.12%), Postives = 91/199 (45.73%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHS-KDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCS----------------------SLAAISP------PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPT 905
            C  C +L+  V +A+ +N +  + +    ++ CD L      +CK+ ++++++  + ++V ++   +IC   G C                       +L  + P      P +  + C +C  +++E+ K I   R  EEI  AL+ VC+  P     QC E VD Y   I+ ++L+  +  ++CS L LC +R  P 
Sbjct:  199 CQDCIQLVTDVQEALRTNSTFVEALVDHAKEECDRLGPGMSDMCKNYINQYSEVAI-QMVMHMQPKEICVLAGFCDEVKEMPMKTLVPAEVVSENVIPALGLVEPIKKDPAPAKADIYCEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGSSILSILLDEASPELVCSMLHLCSSRGLPA 396

[Close]

BLAST of Saposin vs. UniProt/SwissProt
Match: sp|O13035|SAP_CHICK (Prosaposin OS=Gallus gallus OX=9031 GN=PSAP PE=1 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 1.884e-15
Identity = 51/196 (26.02%), Postives = 98/196 (50.00%), Query Frame = 3

Query:  378 ENKSFG-CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSV------LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKF 944
            + K+F  C++C+ ++++V   + SN +++ +  E+E VC  LP   K  CKD ++ +   ++D +++    + +C  +  C   AA  PP++  V       C IC  I+    K++ +     EI+  LE VC+  P     QC +FV++Y   +V+L+ E      +C+ L +C     P +  +D   + P +
Sbjct:  304 QEKTFSVCEICETMVKEVTGLLESNKTEEEIVHEMEVVCYLLPASVKDQCKDFIEVYGQALIDMLLEATNPEAVCVMLKCC---AANKPPQQPVVVKPAGGFCDICKMIVAYADKELEKNATTTEIEALLEKVCHFLPESVSDQCVQFVEQYEPVVVQLLAEMMDPTFVCTKLGVCGAAKKPLL-GEDACVWGPGY 495

HSP 2 Score: 60.4622 bits (145), Expect = 1.058e-8
Identity = 44/195 (22.56%), Postives = 87/195 (44.62%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHS--KDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIV--KNLPADKICQNIGLCSSLAAI---------------------SPPREKSV-LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYP 902
            C  C +L+  V +A+ +N +  K +V    E+ CD L      +CK  + +++D  +  ++  K+     IC  +G C S+ ++                     +  +EK+  +C IC  +++E+   +   +  EEI   +E VC + P   + QC +F++ Y   ++ ++LE      +C  L+ C     P
Sbjct:  197 CQDCIRLVTDVQEAVRTNATFVKSLVAHAKEE-CDRLGPGMSDMCKSYISEYSDLAIQMMMHMKDQQPKDICAMVGFCPSVKSVPLQTLVPAQVVHEVKMETVEKATVQEKTFSVCEICETMVKEVTGLLESNKTEEEIVHEMEVVCYLLPASVKDQCKDFIEVYGQALIDMLLEATNPEAVCVMLKCCAANKPP 390

[Close]

BLAST of Saposin vs. UniProt/SwissProt
Match: sp|P07602|SAP_HUMAN (Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2)

HSP 1 Score: 76.6406 bits (187), Expect = 6.811e-14
Identity = 39/184 (21.20%), Postives = 95/184 (51.63%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS------LAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMY 929
            C+VC+ L+++V   I +N ++  +    +K+C  LP      C+++VD +  +I+  +++ +  + +C  + LCS          ++ P++    C +C +++  + + + +    +EI  ALE  C+  P  Y+ QC++FV  Y   ++++++E      +C  +  C + + P + ++  ++
Sbjct:  315 CEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGG-FCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIW 497

HSP 2 Score: 65.0846 bits (157), Expect = 3.555e-10
Identity = 47/202 (23.27%), Postives = 91/202 (45.05%), Query Frame = 3

Query:  399 DVCKKLIQQVID---AIGSNHS-KDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCS----------------------SLAAISP------PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTI 908
            DVC+  IQ V D   A+ +N +    + + +++ CD L      +CK+ + ++++ I  +++ ++   +IC  +G C                       +L  + P      P +  V C +C  +++E+ K I   +  +EI  A + +C+  P     +C E VD Y   I+ ++LE  +  ++CS L LC     P +
Sbjct:  196 DVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSE-IAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPAL 396

[Close]

BLAST of Saposin vs. UniProt/SwissProt
Match: sp|Q61207|SAP_MOUSE (Prosaposin OS=Mus musculus OX=10090 GN=Psap PE=1 SV=2)

HSP 1 Score: 70.8626 bits (172), Expect = 5.325e-12
Identity = 44/201 (21.89%), Postives = 89/201 (44.28%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC------------------------------------SSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C  C+ ++ +  + I +N +++++ K L   C  LP   +  C+++V  F  +++D  +  +    +C  IGLC                                    S+L A  PP++    C +C +++  +   + +    EEI  ALE  C+  P  Y+ QC++FV  Y   ++++++E    G +CS + +C +
Sbjct:  317 CQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPAHVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPS 517

[Close]

BLAST of Saposin vs. UniProt/SwissProt
Match: sp|P10960|SAP_RAT (Prosaposin OS=Rattus norvegicus OX=10116 GN=Psap PE=1 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 4.584e-11
Identity = 44/201 (21.89%), Postives = 92/201 (45.77%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS------------------------------------LAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C VC+ +++++ + I +N +++++ K L K C  LP      C++++  F  +++D ++  +  + +C  I LCS+                                    L A  PP++    C +C +++  +   + +    EEI  ALE  C+  P  Y+ QC+EFV  Y   ++++++E      +CS + +C +
Sbjct:  314 CQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPS 514

[Close]

BLAST of Saposin vs. TrEMBL
Match: A0A4Y2NU07 (Prosaposin OS=Araneus ventricosus OX=182803 GN=PSAP_1 PE=4 SV=1)

HSP 1 Score: 110.923 bits (276), Expect = 7.993e-23
Identity = 69/283 (24.38%), Postives = 139/283 (49.12%), Query Frame = 3

Query:  255 LCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSE---------------ENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPRE-KSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKFALN*SKKQ*KITNFFKT*YFSSYFILINLICNLLSFI 1055
            +C+L P ++R KC  +       I  + I   +  +M  +E                + +  CD+CK++IQ+V D +    ++D ++  L+KVC  LP      C+  V+++ D IV  +++ L    +C  +GLC S      P+E K + C +C  ++ +I + + E +  +EI+RAL+ VC+  P     +C  FV++Y   ++  I +  + G++C+A+++C   +        +++F+    ++   K+ ++  + K  +  S F+   L  N  +FI
Sbjct:  142 VCSLLPPSYRTKCDNFVNKYTDLIVTLLIQELLNPQMVCAELGLCSSSVLIEQPKGTDNNVECDLCKEVIQKVADMVKDQRTEDEIKAALDKVCSYLPSSISAKCESFVNQYTDLIVTLLMQELDPQMVCAELGLCPSQIKEEKPKELKDLDCDLCKDVVAKIDEIVKENKTEDEIRRALDKVCSYLPSTIASKCEAFVNQYTDYLIAFISQDMSPGLVCAAVEICPMDDVKCEGCLYSLHFVKNELMSNETKE-RMKVYLK--HLCSLFLPQTLAGNCEAFI 421

HSP 2 Score: 101.679 bits (252), Expect = 8.764e-20
Identity = 52/172 (30.23%), Postives = 99/172 (57.56%), Query Frame = 3

Query:  384 KSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPR--EKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAG-GVICSALQLCET 890
            K   C++CK++I +V D +    ++D ++  L+KVC  LP      C   V+++AD IV  +++ L    +C  +GLC +   +  P+  +  V C++C ++I+++ + + + R  E IK AL+ VC++ P  YR +C+ FV++Y   IV L+++      ++C+ L LC +
Sbjct:   17 KDVECELCKEVIGKVEDMVKDQKTEDEIKAALDKVCSYLPSSVSAKCVSFVNQYADLIVTLLIQELDPQLVCAQLGLCPASVLLEQPKGTDNDVECFLCKEVIQKMEQLVNDNRTEEAIKAALDEVCSLLPPSYRTKCDNFVNKYTDLIVTLLIQELLNPQMVCAELGLCSS 188

HSP 3 Score: 98.2117 bits (243), Expect = 1.415e-18
Identity = 50/169 (29.59%), Postives = 99/169 (58.58%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNL-PADKICQNIGLCSSLAAISPPR--EKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            C +CK++IQ++   +  N +++ ++  L++VC  LP  ++  C + V+K+ D IV  +++ L     +C  +GLCSS   I  P+  + +V C +C ++I+++   + ++R  +EIK AL+ VC+  P     +C  FV++Y   IV L+++     ++C+ L LC ++
Sbjct:  112 CFLCKEVIQKMEQLVNDNRTEEAIKAALDEVCSLLPPSYRTKCDNFVNKYTDLIVTLLIQELLNPQMVCAELGLCSSSVLIEQPKGTDNNVECDLCKEVIQKVADMVKDQRTEDEIKAALDKVCSYLPSSISAKCESFVNQYTDLIVTLLMQELDPQMVCAELGLCPSQ 280

HSP 4 Score: 62.003 bits (149), Expect = 1.179e-6
Identity = 43/175 (24.57%), Postives = 83/175 (47.43%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCD-GLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSVL-----------CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            C+ C   +  V + + SN +K+ ++  L+ +C   LP      C+  +D+F ++++  I + +    +C   G+C S A I P     V            C IC+ +++ + K + E  V +EI + +E VC + P  YR +C   ++ Y   I+++I +      +C  + LC
Sbjct:  374 CEGCLYSLHFVKNELMSNETKERMKVYLKHLCSLFLPQTLAGNCEAFIDEFGNSLLVLIAQEIDPSGMCHKAGMCPSNATI-PQLVPDVAIPNLNHFQIDECSICTTVVDYMDKLLEEDDVDKEITQLVEKVCVVLPASYRDKCVSMLETYGPYILQMIGQVANSKQLCQDIDLC 547

[Close]

BLAST of Saposin vs. TrEMBL
Match: A0A4Y2NSQ4 (Prosaposin OS=Araneus ventricosus OX=182803 GN=PSAP_1 PE=4 SV=1)

HSP 1 Score: 110.153 bits (274), Expect = 1.227e-22
Identity = 60/226 (26.55%), Postives = 116/226 (51.33%), Query Frame = 3

Query:  255 LCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSE---------------ENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPRE-KSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            +C+L P ++R KC  +       I  + I   +  +M  +E                + +  CD+CK++IQ+V D +    ++D ++  L+KVC  LP      C+  V+++ D IV  +++ L    +C  +GLC S      P+E K + C +C  ++ +I + + E +  +EI+RAL+ VC+  P     +C  FV++Y   ++  I +  + G++C+A+++C
Sbjct:  142 VCSLLPPSYRTKCDNFVNKYTDLIVTLLIQELLNPQMVCAELGLCSSSVLIEQPKGTDNNVECDLCKEVIQKVADMVKDQRTEDEIKAALDKVCSYLPSSISAKCESFVNQYTDLIVTLLMQELDPQMVCAELGLCPSQIKEEKPKELKDLDCDLCKDVVAKIDEIVKENKTEDEIRRALDKVCSYLPSTIASKCEAFVNQYTDYLIAFISQDMSPGLVCAAVEIC 367

HSP 2 Score: 101.679 bits (252), Expect = 8.965e-20
Identity = 52/172 (30.23%), Postives = 99/172 (57.56%), Query Frame = 3

Query:  384 KSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPR--EKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAG-GVICSALQLCET 890
            K   C++CK++I +V D +    ++D ++  L+KVC  LP      C   V+++AD IV  +++ L    +C  +GLC +   +  P+  +  V C++C ++I+++ + + + R  E IK AL+ VC++ P  YR +C+ FV++Y   IV L+++      ++C+ L LC +
Sbjct:   17 KDVECELCKEVIGKVEDMVKDQKTEDEIKAALDKVCSYLPSSVSAKCVSFVNQYADLIVTLLIQELDPQLVCAQLGLCPASVLLEQPKGTDNDVECFLCKEVIQKMEQLVNDNRTEEAIKAALDEVCSLLPPSYRTKCDNFVNKYTDLIVTLLIQELLNPQMVCAELGLCSS 188

HSP 3 Score: 98.2117 bits (243), Expect = 1.484e-18
Identity = 50/169 (29.59%), Postives = 99/169 (58.58%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNL-PADKICQNIGLCSSLAAISPPR--EKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            C +CK++IQ++   +  N +++ ++  L++VC  LP  ++  C + V+K+ D IV  +++ L     +C  +GLCSS   I  P+  + +V C +C ++I+++   + ++R  +EIK AL+ VC+  P     +C  FV++Y   IV L+++     ++C+ L LC ++
Sbjct:  112 CFLCKEVIQKMEQLVNDNRTEEAIKAALDEVCSLLPPSYRTKCDNFVNKYTDLIVTLLIQELLNPQMVCAELGLCSSSVLIEQPKGTDNNVECDLCKEVIQKVADMVKDQRTEDEIKAALDKVCSYLPSSISAKCESFVNQYTDLIVTLLMQELDPQMVCAELGLCPSQ 280

HSP 4 Score: 62.003 bits (149), Expect = 1.109e-6
Identity = 43/175 (24.57%), Postives = 83/175 (47.43%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCD-GLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSVL-----------CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            C+ C   +  V + + SN +K+ ++  L+ +C   LP      C+  +D+F ++++  I + +    +C   G+C S A I P     V            C IC+ +++ + K + E  V +EI + +E VC + P  YR +C   ++ Y   I+++I +      +C  + LC
Sbjct:  385 CEGCLYSLHFVKNELMSNETKERMKVYLKHLCSLFLPQTLAGNCEAFIDEFGNSLLVLIAQEIDPSGMCHKAGMCPSNATI-PQLVPDVAIPNLNHFQIDECSICTTVVDYMDKLLEEDDVDKEITQLVEKVCVVLPASYRDKCVSMLETYGPYILQMIGQVANSKQLCQDIDLC 558

[Close]

BLAST of Saposin vs. TrEMBL
Match: A0A267GYV9 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig034575g2 PE=4 SV=1)

HSP 1 Score: 105.531 bits (262), Expect = 7.684e-21
Identity = 62/235 (26.38%), Postives = 118/235 (50.21%), Query Frame = 3

Query:  255 LCTLFPETFREKCSEY----------------SPTKPIGISEIEIHAQIKIKMTNSEEN-KSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS---LAAISPPREKSV--LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            +C+L P+T R++C  +                SP +   +  +    Q  +    ++    S  CD C+ ++  V   +  N ++  +   +EKVC+ LP   +P CK  VD++   ++  ++++L   ++CQ +GLC+     AA+   ++ S    C +C  ++ E+ KQ+ +     EI+ AL+ VC++ P   R +C+ FV +Y   I++L++ G +   +CSAL LC  R
Sbjct:  686 VCSLLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRICTVLGLCTQVQQPVSPVRAKLGATSTACDTCQTVVVYVKSLLKENATEQEIIDTVEKVCNFLPTAERPTCKMFVDQYGPYVIQLLLQDLNPMQVCQLLGLCTQKKLQAAVRKQKQISAGPQCLLCEFVMREVDKQLSQNATQTEIEAALQQVCSLLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRVCSALGLCSQR 920

HSP 2 Score: 96.6709 bits (239), Expect = 7.196e-18
Identity = 58/243 (23.87%), Postives = 119/243 (48.97%), Query Frame = 3

Query:  255 LCTLFPETFREKC----SEYSPT---------------KPIGI-SEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISP-------PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYP 902
            +C++ P+T R++C     +++PT                 +G+ S+     ++     +S ++ S  CDVC+ ++Q     +  N ++  + + +E+VC  LP   +  CK  ++++   ++  ++++    +ICQ +GLC++     P       P   S  C  C  ++ E+ +Q+ +     EI+ AL+ VC++ P   R +C+ FV +Y   I++L++ G +   IC+ L LC     P
Sbjct:  493 VCSVLPQTVRQECDNFVQQFTPTIIQLLVNGLSPQRVCSALGLCSQRAPLHRLAPTPKSSTKSSSTTCDVCQTVMQYAKSLLQENATEQEIVQLVERVCSFLPTAEQAACKSFINEYGAYVIQLLLQDANPRQICQLVGLCTTTKMTPPVASLVRKPVRASPQCLTCEFVMREVEQQLSQNATQTEIESALQQVCSLLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRICTVLGLCTQVQQP 735

HSP 3 Score: 94.3597 bits (233), Expect = 3.772e-17
Identity = 50/172 (29.07%), Postives = 88/172 (51.16%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISP------PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            C +C+ ++++V   +  N ++  +   L +VC  LP   +  C   V +F   I+  +V  L   +IC  +GLC++     P      P +    C IC  ++ E+ KQ+G+     EI+ AL  VC++ P   R +C+ FV ++   I++L++ G +   +CSAL LC  R
Sbjct:  368 CLLCEFVMREVDKQLSQNATQTEIEAALLQVCSLLPQTVRQECDGFVQQFTPIIIQLLVNGLSPQRICTVLGLCTASTQRPPVTPVRKPVQAGPQCLICEFVMREVDKQLGQNATQAEIETALLQVCSVLPQTVRQECDNFVQQFTPTIIQLLVNGLSPQRVCSALGLCSQR 539

HSP 4 Score: 78.9518 bits (193), Expect = 5.142e-12
Identity = 55/238 (23.11%), Postives = 106/238 (44.54%), Query Frame = 3

Query:  255 LCTLFPETFREKCSEY-SPTKPI-------GISEIEIHAQIKIKMTNSEE----------NKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAI--------SPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            +C+L P+T R++C  +     PI       G+S   I   + +   +++                C +C+ ++++V   +G N ++  +   L +VC  LP   +  C + V +F  TI+  +V  L   ++C  +GLCS  A +        S  +  S  C +C  +++     + E    +EI + +E VC+  P   +  C  F++ Y   +++L+L+      IC  + LC T
Sbjct:  398 VCSLLPQTVRQECDGFVQQFTPIIIQLLVNGLSPQRICTVLGLCTASTQRPPVTPVRKPVQAGPQCLICEFVMREVDKQLGQNATQAEIETALLQVCSVLPQTVRQECDNFVQQFTPTIIQLLVNGLSPQRVCSALGLCSQRAPLHRLAPTPKSSTKSSSTTCDVCQTVMQYAKSLLQENATEQEIVQLVERVCSFLPTAEQAACKSFINEYGAYVIQLLLQDANPRQICQLVGLCTT 635

HSP 5 Score: 72.0182 bits (175), Expect = 8.043e-10
Identity = 45/186 (24.19%), Postives = 84/186 (45.16%), Query Frame = 3

Query:  357 IKMTNSEENKSFG------CDVCKKLIQQVIDAIGSNHSKDVVRKELEK-VCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLA---AISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            I++   + NK+        C VC+ L+ Q    +    ++  +   +E  VC+ LP   K  C   V ++   +   +   L    +C+ +G C        + P       C +C  ++ E+ KQ+ +     EI+ AL  VC++ P   R +C+ FV ++   I++L++ G +   IC+ L LC
Sbjct:  256 IQLMQLQTNKAIKLAEPIECQVCEDLVNQARQMLRDGRTQAEIESFVESIVCNALPSSEKDQCVKNVQQYGPILFQLLASELDPKTVCEAVGACGKTGRTDRLKPKLGVGPQCLLCEFVMREVDKQLSQNATQTEIEAALLQVCSLLPQTVRQECDGFVQQFTPIIIQLLVNGLSPQRICTVLGLC 441

HSP 6 Score: 71.2478 bits (173), Expect = 1.317e-9
Identity = 41/171 (23.98%), Postives = 81/171 (47.37%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAI--------SPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            C +C+ ++++V   +  N ++  +   L++VC  LP   +  C   V ++   I+  +V  L   ++C  +GLCS  A +        S  +  S +C +C  +++     + E    +EI + +E VC+  P   +  C  F++ Y   +++L+L+      IC  L LC
Sbjct:  844 CLLCEFVMREVDKQLSQNATQTEIEAALQQVCSLLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRVCSALGLCSQRAPLHRLAPTPKSSTKSSSTVCDVCQTVMQYAKSLLQENATEQEIVQLVERVCSFLPTAEQAACKSFINEYGAYVIQLLLQDANPRQICQLLGLC 1014

[Close]

BLAST of Saposin vs. TrEMBL
Match: A0A1I8G4W7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig034575g1 PE=4 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 2.893e-20
Identity = 62/235 (26.38%), Postives = 117/235 (49.79%), Query Frame = 3

Query:  255 LCTLFPETFREKCSEY----------------SPTKPIGISEIEIHAQIKIKMTNSEEN-KSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS---LAAISPPREKSV--LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            +C+L P+T R++C  +                SP +   +  +    Q  +    ++    S  CD C+ ++  V   +  N ++  +   +EKVC+ LP   +P CK  VD++   ++  ++++L   ++CQ +GLC+     AA+   ++ S    C +C  ++ E+ KQ+ +     EI+ AL  VC++ P   R +C+ FV +Y   I++L++ G +   +CSAL LC  R
Sbjct:  686 VCSLLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRICTVLGLCTQVQQPVSPVRAKLGATSTACDTCQTVVVYVKSLLKENATEQEIIDTVEKVCNFLPTAERPTCKMFVDQYGPYVIQLLLQDLNPMQVCQLLGLCTQKKLQAAVRKQKQISAGPQCLLCEFVMREVDKQLSQNATQTEIEAALLQVCSVLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRVCSALGLCSQR 920

HSP 2 Score: 97.0561 bits (240), Expect = 5.117e-18
Identity = 58/243 (23.87%), Postives = 119/243 (48.97%), Query Frame = 3

Query:  255 LCTLFPETFREKC----SEYSPT---------------KPIGI-SEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISP-------PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYP 902
            +C++ P+T R++C     +++PT                 +G+ S+     ++     +S ++ S  CDVC+ ++Q     +  N ++  + + +E+VC  LP   +  CK  ++++   ++  ++++    +ICQ +GLC++     P       P   S  C  C  ++ E+ +Q+ +     EI+ AL+ VC++ P   R +C+ FV +Y   I++L++ G +   IC+ L LC     P
Sbjct:  493 VCSVLPQTVRQECDNFVQQFTPTIIQLLVNGLSPQRVCSALGLCSQRAPLHRLAPTPKSSTKSSSTTCDVCQTVMQYAKSLLQENATEQEIVQLVERVCSFLPTAEQAACKSFINEYGAYVIQLLLQDANPRQICQLVGLCTTTKMTPPVASLVRKPARASPQCLTCEFVMREVEQQLSQNATQTEIESALQQVCSLLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRICTVLGLCTQVQQP 735

HSP 3 Score: 92.4337 bits (228), Expect = 1.456e-16
Identity = 49/172 (28.49%), Postives = 88/172 (51.16%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISP------PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            C +C+ ++++V   +  N ++  +   L +VC  LP   +  C   V ++   I+  +V  L   +IC  +GLC++     P      P +    C IC  ++ E+ KQ+G+     EI+ AL  VC++ P   R +C+ FV ++   I++L++ G +   +CSAL LC  R
Sbjct:  368 CLLCEFVMREVDKQLSQNATQAEIEAALLQVCSLLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRICTVLGLCTASTQRPPVTPVRKPVQAGPQCLICEFVMREVDKQLGQNATQAEIETALLQVCSVLPQTVRQECDNFVQQFTPTIIQLLVNGLSPQRVCSALGLCSQR 539

HSP 4 Score: 78.9518 bits (193), Expect = 5.050e-12
Identity = 55/238 (23.11%), Postives = 106/238 (44.54%), Query Frame = 3

Query:  255 LCTLFPETFREKCSEY-SPTKPI-------GISEIEIHAQIKIKMTNSEE----------NKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAI--------SPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            +C+L P+T R++C  +     PI       G+S   I   + +   +++                C +C+ ++++V   +G N ++  +   L +VC  LP   +  C + V +F  TI+  +V  L   ++C  +GLCS  A +        S  +  S  C +C  +++     + E    +EI + +E VC+  P   +  C  F++ Y   +++L+L+      IC  + LC T
Sbjct:  398 VCSLLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRICTVLGLCTASTQRPPVTPVRKPVQAGPQCLICEFVMREVDKQLGQNATQAEIETALLQVCSVLPQTVRQECDNFVQQFTPTIIQLLVNGLSPQRVCSALGLCSQRAPLHRLAPTPKSSTKSSSTTCDVCQTVMQYAKSLLQENATEQEIVQLVERVCSFLPTAEQAACKSFINEYGAYVIQLLLQDANPRQICQLVGLCTT 635

HSP 5 Score: 73.559 bits (179), Expect = 2.764e-10
Identity = 46/186 (24.73%), Postives = 84/186 (45.16%), Query Frame = 3

Query:  357 IKMTNSEENKSFG------CDVCKKLIQQVIDAIGSNHSKDVVRKELEK-VCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLA---AISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            I++   + NK+        C VC+ L+ Q    +    ++  +   +E  VC+ LP   K  C   V ++   +   +   L    +C+ +G C        + P       C +C  ++ E+ KQ+ +     EI+ AL  VC++ P   R +C+ FV +Y   I++L++ G +   IC+ L LC
Sbjct:  256 IQLMQLQTNKAIKLAEPIECQVCEDLVNQARQMLRDGRTQAEIESFVESIVCNALPSSEKDQCVKNVQQYGPILFQLLASELDPKTVCEAVGACGKTGRTDRLKPKLGVGPQCLLCEFVMREVDKQLSQNATQAEIEAALLQVCSLLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRICTVLGLC 441

HSP 6 Score: 69.3218 bits (168), Expect = 6.083e-9
Identity = 41/171 (23.98%), Postives = 80/171 (46.78%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAI--------SPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            C +C+ ++++V   +  N ++  +   L +VC  LP   +  C   V ++   I+  +V  L   ++C  +GLCS  A +        S  +  S +C +C  +++     + E    +EI + +E VC+  P   +  C  F++ Y   +++L+L+      IC  L LC
Sbjct:  844 CLLCEFVMREVDKQLSQNATQTEIEAALLQVCSVLPQTVRQECDGFVQQYTPIIIQLLVNGLSPQRVCSALGLCSQRAPLHRLAPTPKSSTKSSSTVCDVCQTVMQYAKSLLQENATEQEIVQLVERVCSFLPTAEQAACKSFINEYGAYVIQLLLQDANPRQICQLLGLC 1014

[Close]

BLAST of Saposin vs. TrEMBL
Match: A0A1E1X7J6 (Putative saposin OS=Amblyomma aureolatum OX=187763 PE=2 SV=1)

HSP 1 Score: 103.219 bits (256), Expect = 4.976e-20
Identity = 63/213 (29.58%), Postives = 109/213 (51.17%), Query Frame = 3

Query:  327 SEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSV----LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKFALN 953
            S++  +A +  K  + EE     CD+CK ++Q V + +    +++ V++ L++VC  LP   +  C D V+ + D +VD IV+    +++CQ IGLC+S    +P R   V     C  C+ I++ ++  + +++  EEIK  L+  C +F    R +C   V+ Y   IV LIL+      IC  + LC     P+    D    L ++AL+
Sbjct:  801 SKLPPYASVSPKKPSDEE-----CDICKVIVQFVYNELKDKKTEEEVKQLLDQVCSLLPDSLRQTCIDTVNPYYDQLVDLIVQGFTPEQVCQEIGLCTSARKPTPTRPTKVADDQTCTYCTTIVQYVYDALADQKTEEEIKETLDAACMLFHGDARKECTNIVNTYFEIIVSLILKDFTPEQICQTIGLC-----PSAPGGDLECTLCQYALH 1003

HSP 2 Score: 96.6709 bits (239), Expect = 6.349e-18
Identity = 59/232 (25.43%), Postives = 114/232 (49.14%), Query Frame = 3

Query:  255 LCTLFPETFREKC----------------SEYSPTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISP----PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
             C LFP   ++KC                 E++P +     +      + + +   ++     CD+C  +I+ V D I    +++ +++ L++VC  LP   +  C ++V+ + D +V+ +++ L  +++CQ +GLCSS    S     P   S  C +C  I++ I+ ++ +R+  EEIK+ L+ VC++ P     +C   V+ Y   +V LI +G +   +C  + LC T
Sbjct:  566 FCQLFPAASKDKCISTINSYVDMVISLILQEFTPEQICQELKFCASTNVSLPVVPPKKVSDDKCDLCMVVIKFVYDQIKDEKTEERIKQALDQVCSLLPDSLQQKCVNMVNTYYDMLVNLLLQELVPEQVCQELGLCSSAPGKSTETKLPTSASEECPLCEIIVKLIYNELKDRKTEEEIKQMLDKVCSLLPTSLEQRCTNTVNIYFDLLVTLITQGLSPEEVCQEIGLCPT 797

HSP 3 Score: 94.3597 bits (233), Expect = 4.264e-17
Identity = 59/246 (23.98%), Postives = 122/246 (49.59%), Query Frame = 3

Query:  255 LCTLFPETFREKCSEYSPT-------------------KPIGI--SEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS--------LAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPT 905
            +C+L P++ ++KC     T                   + +G+  S      + K+  + SEE     C +C+ +++ + + +    +++ +++ L+KVC  LP   +  C + V+ + D +V  I + L  +++CQ IGLC +         A++SP +     C IC  I++ ++ ++ +++  EE+K+ L+ VC++ P   R  C + V+ Y  ++V LI++G     +C  + LC +   PT
Sbjct:  659 VCSLLPDSLQQKCVNMVNTYYDMLVNLLLQELVPEQVCQELGLCSSAPGKSTETKLPTSASEE-----CPLCEIIVKLIYNELKDRKTEEEIKQMLDKVCSLLPTSLEQRCTNTVNIYFDLLVTLITQGLSPEEVCQEIGLCPTGKESKLPPYASVSPKKPSDEECDICKVIVQFVYNELKDKKTEEEVKQLLDQVCSLLPDSLRQTCIDTVNPYYDQLVDLIVQGFTPEQVCQEIGLCTSARKPT 899

HSP 4 Score: 75.8702 bits (185), Expect = 4.435e-11
Identity = 42/163 (25.77%), Postives = 78/163 (47.85%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            C  C  ++Q V DA+    +++ +++ L+  C       +  C +IV+ + + IV  I+K+   ++ICQ IGLC S           + C +C   +  I  ++ +     +++  LE +C   PV    +C  FVD Y   I+ LI +     ++C A++ C
Sbjct:  912 CTYCTTIVQYVYDALADQKTEEEIKETLDAACMLFHGDARKECTNIVNTYFEIIVSLILKDFTPEQICQTIGLCPSAPG------GDLECTLCQYALHFIQNELVDNSTETQVEAVLENLCTKLPVGLAKECKAFVDEYGPAIMVLIAQEIDPSIVCVAIKAC 1068

HSP 5 Score: 65.855 bits (159), Expect = 7.933e-8
Identity = 45/174 (25.86%), Postives = 83/174 (47.70%), Query Frame = 3

Query:  390 FGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSVL-----CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRN 896
            + C +CK  I  +   +  N + D V+  L+++C+  P   +  C+  VDK A+ I+  +  ++    IC  I LCS      PP++  ++     C  C   +   + ++ ++   EEIKR +E  C +FP   + +C   ++ Y   ++ LIL+      IC  L+ C + N
Sbjct:  444 YTCSICKAFITLLEQVVPLNATVDDVKYLLDQICELFPAETEKNCRSFVDKNAEVILKFLAHDVAPAIICHEIMLCSP----PPPKKTGIIADSPDCDYCKLTVGFFYDELKKKETEEEIKRVVEKFCQLFPAASKDKCISTINSYVDMVISLILQEFTPEQICQELKFCASTN 613

[Close]

BLAST of Saposin vs. Ensembl Cavefish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 67.781 bits (164), Expect = 5.301e-12
Identity = 37/145 (25.52%), Postives = 74/145 (51.03%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLA-AISPPREKS-----VLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRY 812
            C +C+ +++++ D I    +++ V + +EKVC+ LP      CKD+++ +   I++ +V+      IC  +GLC   + A  P  EK+       C +C   +  +   + +     +I+ A+  VCN  P  ++ QC++ V +Y
Sbjct:  301 CAICEYVMKELEDMIQDQTTEEEVMQAVEKVCNILPSTLTAQCKDLIETYGQAIIELLVQEADPKTICTVLGLCKGASRAFIPVMEKADFQAGGFCDVCKMAVRYVDGILEQNATEAQIEEAVRKVCNFLPDEFKTQCDQLVQQY 445

HSP 2 Score: 59.3066 bits (142), Expect = 2.842e-9
Identity = 34/109 (31.19%), Postives = 59/109 (54.13%), Query Frame = 3

Query:  570 VKNLPADKICQNIGLCSS---LAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCE 887
            VK+LPA K+ +   L  +   + A  PP+     C IC  +++E+   I ++   EE+ +A+E VCNI P     QC + ++ Y   I++L+++      IC+ L LC+
Sbjct:  272 VKSLPATKVVEATPLKPAKKMVRAREPPQ-----CAICEYVMKELEDMIQDQTTEEEVMQAVEKVCNILPSTLTAQCKDLIETYGQAIIELLVQEADPKTICTVLGLCK 375

[Close]

BLAST of Saposin vs. Ensembl Cavefish
Match: psap (prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1])

HSP 1 Score: 60.077 bits (144), Expect = 1.643e-9
Identity = 36/120 (30.00%), Postives = 64/120 (53.33%), Query Frame = 3

Query:  570 VKNLPADKICQNIGLCSS---LAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKD 920
            VK+LPA K+ +   L  +   + A  PP+     C IC  +++E+   I ++   EE+ +A+E VCNI P     QC + ++ Y   I++L+++      IC+ L LC+  + P ++  D
Sbjct:  272 VKSLPATKVVEATPLKPAKKMVRAREPPQ-----CAICEYVMKELEDMIQDQTTEEEVMQAVEKVCNILPSTLTAQCKDLIETYGQAIIELLVQEADPKTICTVLGLCKGAS-PVMEKAD 385

HSP 2 Score: 58.5362 bits (140), Expect = 4.703e-9
Identity = 34/136 (25.00%), Postives = 67/136 (49.26%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKS-----VLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQ 788
            C +C+ +++++ D I    +++ V + +EKVC+ LP      CKD+++ +   I++ +V+      IC  +GLC      SP  EK+       C +C   +  +   + +     +I+ A+  VCN  P  ++ Q
Sbjct:  301 CAICEYVMKELEDMIQDQTTEEEVMQAVEKVCNILPSTLTAQCKDLIETYGQAIIELLVQEADPKTICTVLGLCK---GASPVMEKADFQAGGFCDVCKMAVRYVDGILEQNATEAQIEEAVRKVCNFLPDEFKTQ 433

[Close]

BLAST of Saposin vs. Ensembl Cavefish
Match: sftpbb (surfactant protein Bb [Source:NCBI gene;Acc:100001978])

HSP 1 Score: 55.0694 bits (131), Expect = 1.408e-8
Identity = 44/164 (26.83%), Postives = 70/164 (42.68%), Query Frame = 3

Query:  522 CKDIVDKFADTIVDEIVKNLPADKICQNIGLCS-------------SLAA-----------ISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPK 941
            C  I++ F D +      N   D IC+ +GLC+             SL A            SP  + +  C  C  II ++   + + R   EI +ALE +CN  P  Y+ QCN F++ Y  +I+  +L       IC+ L LC       ++ +  M ++P 
Sbjct:    5 CTQIMELFLDMLSK---PNTQGD-ICKVLGLCTVQPESKAPEMLHVSLEADGFIQAQPSTQTSPEVQITPQCTFCLFIIRKLENMLPKERT--EIVKALETICNHLPDHYKDQCNSFLETYGKQILDFLLTSATPHTICALLHLC------LMQERSDMPYMPS 156

[Close]

BLAST of Saposin vs. Ensembl Cavefish
Match: sftpba (prosaposin-like [Source:NCBI gene;Acc:103040133])

HSP 1 Score: 55.0694 bits (131), Expect = 4.952e-8
Identity = 46/187 (24.60%), Postives = 75/187 (40.11%), Query Frame = 3

Query:  393 GCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLA------AISPPREKSVL-----------CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYP 902
             C  C  +I+ + D I     ++ ++  LEK+CD LP      CK+ VDK     +  I   +   ++C  +GLC           I    +K VL           C +C+ + + +  Q    +    +   L   C I P + R QC   V  Y   ++  +L   +   +CS L+LCE    P
Sbjct:   42 ACQDCIHIIELLKDLISEGEFQEKIKGLLEKLCDSLPGEIPKTCKEQVDKNLPLAITFISSIMIPGEVCAYLGLCDGQMRGQMKELIMNHMQKIVLLPDITVNSSIPCTLCTYVTDLL--QCIIPKTQTLLISLLGDACQILPPLLRGQCTVLVKTYVKMLINFLLNFASPDKLCSVLRLCENLEIP 226

[Close]

BLAST of Saposin vs. Ensembl Cavefish
Match: ENSAMXT00000035797.1 (prosaposin-like [Source:NCBI gene;Acc:107197742])

HSP 1 Score: 48.521 bits (114), Expect = 7.773e-7
Identity = 25/74 (33.78%), Postives = 44/74 (59.46%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC 617
            C  CK  + ++  ++G+N SK+ V+  L  VCDG+ F+ K +C  +V ++ D +V+E+        IC +IG+C
Sbjct:   52 CWACKWAMGRLKSSLGTNTSKEAVKAMLGTVCDGIGFL-KFLCNRMVKRYFDVLVEELSTVDNPAIICSHIGVC 124

[Close]

BLAST of Saposin vs. Ensembl Nematostella
Match: EDO39178 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAT7])

HSP 1 Score: 81.2629 bits (199), Expect = 4.168e-17
Identity = 48/168 (28.57%), Postives = 91/168 (54.17%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIV---DEIVKNLPADKICQNIGLCSSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCET 890
            C +C+  + ++ D IG N  +  ++  LE  C      +  VCK +VD++   I+   D++V+N  + ++C  +GLCS+   + P  + +  C +C  +++EI + + +    + I++AL  VC+I P   R+ C++FV  Y   I+ L+LE      +CS + LC +
Sbjct:  197 CSICELAVDKIRDVIGDNSIQAEIKGVLEDACVKEGGAYAGVCKALVDQYFPIIISHLDKLVQN--SKQVCTALGLCSADRWVCPRPDDAPQCVLCEFVMKEIKQLLAKDTTQQGIEKALMMVCSIMPETIRNNCDKFVTEYTPIIMSLLLEEVDPAKVCSMIGLCNS 362

[Close]

BLAST of Saposin vs. Ensembl Nematostella
Match: EDO31455 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXX5])

HSP 1 Score: 67.0106 bits (162), Expect = 3.161e-12
Identity = 47/192 (24.48%), Postives = 88/192 (45.83%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLP-ADKICQNIGLCSS--------LAAISP---------------PREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNY 899
            C  C++ +  V   + +   +D +   L KVC       K  C+ +V+ F   IV  +V  L    K+C  IGLC++         AA S                P + S  C +C  +++E+   + +    +EI +A+E VC+I P   + +C++FV  Y   +++++ +  +  ++C+ L LC  R +
Sbjct:  130 CITCQEAVNTVYKFVSNPAIEDEIVALLSKVCSEFG-AEKATCEAVVNTFGKQIVQTLVSLLSDGKKLCTEIGLCTANKVKAMLVQAAASHKVMFTPKKHVLKATYPVKTSTECVLCEFVMKELDDMLSKNSTQQEIIQAVEKVCSILPSTIKSKCDQFVQEYGPALIEILEQEVSPKLVCTTLGLCANREH 320

HSP 2 Score: 63.5438 bits (153), Expect = 4.464e-11
Identity = 43/184 (23.37%), Postives = 83/184 (45.11%), Query Frame = 3

Query:  387 SFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSVL-------CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSK 917
            S  C +C+ +++++ D +  N ++  + + +EKVC  LP   K  C   V ++   +++ + + +    +C  +GLC++       R    L       C IC+ ++  +   +      EEI   LE VCN  P     +CN  V  Y   ++++I        +C  + LC + N   +K+K
Sbjct:  239 STECVLCEFVMKELDDMLSKNSTQQEIIQAVEKVCSILPSTIKSKCDQFVQEYGPALIEILEQEVSPKLVCTTLGLCANREHRIAMRRSHKLVIGSNETCEICTTVMTYLKAFLNNNATDEEIVNFLEKVCNYLPSQIASECNAIVSEYGSTVLQIIANTDP-TTLCKEIGLC-SANQHVMKAK 420

HSP 3 Score: 48.9062 bits (115), Expect = 1.981e-6
Identity = 37/143 (25.87%), Postives = 67/143 (46.85%), Query Frame = 3

Query:  255 LCTLFPETFREKC----SEYSPTKPIGISEIEIHAQI-------------KIKMTNSEE---NKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS 623
            +C++ P T + KC     EY P   I I E E+  ++             +I M  S +     +  C++C  ++  +   + +N + + +   LEKVC+ LP      C  IV ++  T++ +I+ N     +C+ IGLCS+
Sbjct:  272 VCSILPSTIKSKCDQFVQEYGPAL-IEILEQEVSPKLVCTTLGLCANREHRIAMRRSHKLVIGSNETCEICTTVMTYLKAFLNNNATDEEIVNFLEKVCNYLPSQIASECNAIVSEYGSTVL-QIIANTDPTTLCKEIGLCSA 412

[Close]

BLAST of Saposin vs. Ensembl Nematostella
Match: EDO38309 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDD7])

HSP 1 Score: 62.7734 bits (151), Expect = 4.988e-11
Identity = 54/220 (24.55%), Postives = 94/220 (42.73%), Query Frame = 3

Query:  342 HAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTI---VDEIVKNLPADKICQNIGLCS-----------------------SLAAISP----PREKSV---------LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC 884
            H Q K+   + +E  SF CD CK++I ++         +D + + ++K C  LP      CK+++ +    +   +D IVK+  A  +C+ + LCS                       SL    P    P  K V          C +C  ++ E+ K + E    EEI+ AL  +C+  P   + +C  FV  Y   I++++ +     ++C  L+LC
Sbjct:   55 HCQEKVWKNSIKEKNSFPCDTCKEVIGKIKKFAEDESLQDKIIQTMDKACSLLPSELSAKCKEVMGEAIKKLFASLDSIVKDPAA--LCKKLKLCSAQSKEEILKAVIKHLLSKDQQVSSLLMPGPVMMVPSRKPVHKLMIKTSETCVMCEFVMRELSKMLNENSTKEEIETALNKLCSYMPGSIQSECKTFVQEYTPFIIEILSKEFKPELVCRELKLC 272

HSP 2 Score: 54.6842 bits (130), Expect = 2.261e-8
Identity = 35/178 (19.66%), Postives = 84/178 (47.19%), Query Frame = 3

Query:  387 SFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAA--------ISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFP-VIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR 893
            S  C +C+ +++++   +  N +K+ +   L K+C  +P   +  CK  V ++   I++ + K    + +C+ + LCS+  A        + P    +  C +C  +++++   + +    + I+  L  +C+  P V  + QC+  +  Y  E++   ++ +    IC  L +C ++
Sbjct:  196 SETCVMCEFVMRELSKMLNENSTKEEIETALNKLCSYMPGSIQSECKTFVQEYTPFIIEILSKEFKPELVCRELKLCSAGGATYLAVAKLLKPRLTANKGCDVCQTVVKDVQSALKDDVTVKGIEDMLSMICDYIPEVEIKKQCSVAIQHYVPELIDFFIK-QDPKTICKDLDMCSSK 372

[Close]

BLAST of Saposin vs. Ensembl Medaka
Match: sftpbb (prosaposin-like [Source:NCBI gene;Acc:101161410])

HSP 1 Score: 66.6254 bits (161), Expect = 6.201e-12
Identity = 42/192 (21.88%), Postives = 81/192 (42.19%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCS-----------------SLAAISPPREKSV------LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYP 902
            C  C ++I+   + I  + +K  V + L  VC  LP      C+  V  +   ++ +   +L   + C   GLC+                 +L+  +P            +C +C  +I ++   + +    + I + +E VC++ P  Y+ QC++FV++Y  +I + +    A   IC  L LC  +  P
Sbjct:   17 CGECSQIIRTSTNMISGSDTKVTVYEALHAVCRRLPERQASDCQSQVKTYLPKVLQQKPSHLNPSETCVVFGLCAPQKDEELQEPPPSVNSEALSNSAPASATETQKISGPVCALCLMVIRKLETMLPKNISEDAILKIMEEVCDLVPASYKQQCDDFVNKYGADIAEFLFSSAAPHTICMVLHLCLFKEQP 208

[Close]

BLAST of Saposin vs. Ensembl Medaka
Match: sftpbb (prosaposin-like [Source:NCBI gene;Acc:101161410])

HSP 1 Score: 66.6254 bits (161), Expect = 7.756e-12
Identity = 42/192 (21.88%), Postives = 81/192 (42.19%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCS-----------------SLAAISPPREKSV------LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYP 902
            C  C ++I+   + I  + +K  V + L  VC  LP      C+  V  +   ++ +   +L   + C   GLC+                 +L+  +P            +C +C  +I ++   + +    + I + +E VC++ P  Y+ QC++FV++Y  +I + +    A   IC  L LC  +  P
Sbjct:   41 CGECSQIIRTSTNMISGSDTKVTVYEALHAVCRRLPERQASDCQSQVKTYLPKVLQQKPSHLNPSETCVVFGLCAPQKDEELQEPPPSVNSEALSNSAPASATETQKISGPVCALCLMVIRKLETMLPKNISEDAILKIMEEVCDLVPASYKQQCDDFVNKYGADIAEFLFSSAAPHTICMVLHLCLFKEQP 232

[Close]

BLAST of Saposin vs. Ensembl Medaka
Match: psap (prosaposin [Source:NCBI gene;Acc:101163196])

HSP 1 Score: 62.3882 bits (150), Expect = 2.862e-10
Identity = 34/145 (23.45%), Postives = 77/145 (53.10%), Query Frame = 3

Query:  396 CDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSS-----LAAISPPREKS-VLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRY 812
            C +C+ +++QV   +    +++ V + ++KVC  +P      CKD+++ + + I++ +V+ +    +C  + LC+      + A+  PR K+   C +C   +  I   + +     EI+ A++ VC+  P  Y+ +C++ V++Y
Sbjct:  322 CAICEFVMKQVEAMLTDETTEEEVIQAVQKVCYLVPSSLTAQCKDLIETYGEAIIELLVQEVDPKTVCTMLALCNDASRAYVVALDQPRFKTGGYCEVCKMAVGYIDGILEKNATEAEIEEAVKKVCSFLPDAYKTECDQLVEQY 466

HSP 2 Score: 51.6026 bits (122), Expect = 7.869e-7
Identity = 45/220 (20.45%), Postives = 90/220 (40.91%), Query Frame = 3

Query:  393 GCDVCKKLIQQVIDAIGSNHSK----DVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSL----------AAISPPREKSV--------------------------LCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYF 932
            G +VC+  I+ + DA     +     + + + +E  CD L      +CK  V ++   +V +++   P  +IC   G CS +          AA + P  KS+                           C IC  +++++   + +    EE+ +A++ VC + P     QC + ++ Y   I++L+++      +C+ L LC   +   + + D   F
Sbjct:  193 GDEVCQDCIKFLTDAQAEAKANSSFINSLIQNIEGQCDLLGPGLSDMCKQYVGQYGPVVVQQLMSMQP-KQICAMAGFCSEVKKSVPMMTLQAAKTIPAAKSIPALELFPATKVEAAAAKRLVRVKESPQCAICEFVMKQVEAMLTDETTEEEVIQAVQKVCYLVPSSLTAQCKDLIETYGEAIIELLVQEVDPKTVCTMLALCNDASRAYVVALDQPRF 411

[Close]

BLAST of Saposin vs. Planmine SMEST
Match: SMESG000019975.1 (SMESG000019975.1)

HSP 1 Score: 533.102 bits (1372), Expect = 0.000e+0
Identity = 264/265 (99.62%), Postives = 264/265 (99.62%), Query Frame = 3

Query:  159 MKICYFLGIFLLSSIHCVYEKINPISPGEKKLLCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKFALN 953
            MKI YFLGIFLLSSIHCVYEKINPISPGEKKLLCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKFALN
Sbjct:    1 MKIFYFLGIFLLSSIHCVYEKINPISPGEKKLLCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKFALN 265

[Close]

BLAST of Saposin vs. Planmine SMEST
Match: SMESG000019976.1 (SMESG000019976.1)

HSP 1 Score: 188.348 bits (477), Expect = 1.486e-58
Identity = 92/166 (55.42%), Postives = 120/166 (72.29%), Query Frame = 3

Query:  159 MKICYFLGIFLLSSIHCVYEKINPISPGEKKLLCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREKS 656
            MKI YF GIFLLSS+ C+Y +IN IS GEKKLLCTLFPETF+EKC+E+   K   +++IE HA+++IK TN+EENKS  CD+CKK+I++VI    + HS+  + K LEKVCD LP V K  CK  V  F D IV++I+KN+PA KIC++IG C S      P+ K+
Sbjct:    1 MKISYFFGIFLLSSLQCLYGEINKISSGEKKLLCTLFPETFKEKCAEFINKKSFVLNQIEFHAKVQIKTTNTEENKSLRCDICKKIIERVIKETKNKHSRYAILKALEKVCDELPEVMKSSCKYAVQNFGDKIVNDIMKNVPAKKICEDIGFCDSGEIERAPKIKT 166

HSP 2 Score: 63.929 bits (154), Expect = 7.009e-12
Identity = 35/113 (30.97%), Postives = 57/113 (50.44%), Query Frame = 3

Query:  624 LAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLC---ETRNYPTIKSKDTMYFLPKFALN 953
            +   +    KS+ C IC +IIE + K+   +     I +ALE VC+  P + +  C   V  +  +IV  I++      IC  +  C   E    P IK+++ +YFLPKF+L+
Sbjct:   67 IKTTNTEENKSLRCDICKKIIERVIKETKNKHSRYAILKALEKVCDELPEVMKSSCKYAVQNFGDKIVNDIMKNVPAKKICEDIGFCDSGEIERAPKIKTEEALYFLPKFSLD 179

[Close]

BLAST of Saposin vs. Planmine SMEST
Match: SMESG000019977.1 (SMESG000019977.1)

HSP 1 Score: 98.2117 bits (243), Expect = 2.975e-24
Identity = 65/169 (38.46%), Postives = 98/169 (57.99%), Query Frame = 3

Query:  159 MKICYFLGIFLLSSIHCVYEKINPISPGEKKLLCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLC-SSLAAISPPREKSVL 662
            MK    LGI +  +I+  Y +    S GE KLLCTLFP+TF+EKCSE+         +IEI A I+I++ N E+ KS  C +CKK+I  +I  IG N +K  + + ++ +C     V++  CK ++ K+   I+D I+K + +D+IC+ +GLC S L  I     K  L
Sbjct:    1 MKSLILLGIIIFCNINFFYGEEIQNSAGEIKLLCTLFPQTFKEKCSEFINEDSTSKCKIEITANIEIEV-NDEKGKS-KCKLCKKVIGAIIKYIGKNPTKKKIIEAMKVICKFFG-VFEFECKLLIKKYGPKILDYIMKWMSSDQICKKLGLCHSQLGMIKAIEAKDTL 166

HSP 2 Score: 51.6026 bits (122), Expect = 1.002e-7
Identity = 29/98 (29.59%), Postives = 53/98 (54.08%), Query Frame = 3

Query:  663 CWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETR--NYPTIKSKDTMYFLPKFAL 950
            C +C ++I  I K IG+    ++I  A++ +C  F V +  +C   + +Y  +I+  I++  +   IC  L LC ++      I++KDT+ FLP  +L
Sbjct:   78 CKLCKKVIGAIIKYIGKNPTKKKIIEAMKVICKFFGV-FEFECKLLIKKYGPKILDYIMKWMSSDQICKKLGLCHSQLGMIKAIEAKDTLKFLPILSL 174

[Close]

BLAST of Saposin vs. Planmine SMEST
Match: SMESG000019973.1 (SMESG000019973.1)

HSP 1 Score: 71.2478 bits (173), Expect = 7.974e-14
Identity = 58/242 (23.97%), Postives = 116/242 (47.93%), Query Frame = 3

Query:  246 KKLLCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQ----------NIGLCSSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPK 941
            KK LC +FP++ + +C  Y+        E  I  Q +               +CK++   +   + ++ S + ++K     C+      + +CK   ++    I+ +++K     K+C+          N GL ++ + ++ P E    C +C +II+ + + + +    EEI  AL  VC++ P     QC  F+D+YA +I+  +++G    ++C  L +C +++  T+  +DTMYF+PK
Sbjct:   36 KKALCEMFPKSLKVEC--YTEPDKSDDKEFYIPHQHQF--------------ICKRIAMFLGHDLDTSKSPEQLKKLFLPTCNMFRSHLRNICKKFTEEEGKKIIKKLLKKENPKKVCKKRLLRVSVGKNNGLITAKSKVNNPLE----CLLCKEIIKYLDEILKKESTKEEILLALNKVCSLLPANKSKQCVLFIDKYASKIMDFLVDGNPPEMVCHFLLVCSSKD--TV-PEDTMYFIPK 254

[Close]

BLAST of Saposin vs. Planmine SMEST
Match: SMESG000020046.1 (SMESG000020046.1)

HSP 1 Score: 64.6994 bits (156), Expect = 1.138e-11
Identity = 55/239 (23.01%), Postives = 104/239 (43.51%), Query Frame = 3

Query:  255 LCTLFPETFREKCSEYSPTKPIGISEIEIHAQIKIKMTNSEENK---SFGCDVCKKLIQQVIDAIGSNHSKDVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNIGLCSSLAAISPPREK----SVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVCNIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTIKSKDTMYFLPKFAL 950
            +C L P+ F+ +CS  S         I++HAQ+ ++M+  +E++      C  C   +  +   I ++ + D V+  L  +C  +    K    D + K    ++  I+K     KICQ    C  +  I    +K    S  C IC  +  ++      +   E+I + +   C+  P    ++C  F+  +  +I+  ++       +C +L+LC T+     KS DT++ LP   L
Sbjct:   33 ICRLLPKAFQLQCS--SLLHENNNKHIKVHAQLDLEMSKDKESRWKPKRKCFKCIAFVYMLERFINTSLTSDQVQNHLLDLCQIISSPKKEKIIDFLKKEGPKLIPRILKKDCPIKICQMENFCHKIEVIFENDDKVPNPSKYCSICQSVSNQLGSLRKLKLSKEKINQVVGTACSFGPTAQANECKAFLSIFQDKIISFMITEDKTVSLCESLRLCSTQK----KSSDTLFGLPMLEL 265

The following BLAST results are available for this feature:

BLAST of Saposin vs. Ensembl Human
BLAST of Saposin vs. Ensembl Celegans
BLAST of Saposin vs. Ensembl Fly
BLAST of Saposin vs. Ensembl Zebrafish
BLAST of Saposin vs. Ensembl Xenopus
BLAST of Saposin vs. Ensembl Mouse
BLAST of Saposin vs. UniProt/SwissProt
BLAST of Saposin vs. TrEMBL
BLAST of Saposin vs. Ensembl Cavefish
BLAST of Saposin vs. Ensembl Sea Lamprey
BLAST of Saposin vs. Ensembl Yeast
BLAST of Saposin vs. Ensembl Nematostella
BLAST of Saposin vs. Ensembl Medaka
BLAST of Saposin vs. Planmine SMEST

BLAST of Saposin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
PSAP	1.255e-14	21.20	prosaposin [Source:HGNC Symbol;Acc:HGNC:9498]	[more]
PSAP	1.418e-14	21.20	prosaposin [Source:HGNC Symbol;Acc:HGNC:9498]	[more]
PSAPL1	1.379e-10	22.91	prosaposin like 1 (gene/pseudogene) [Source:HGNC S...	[more]
PSAP	4.215e-7	20.00	prosaposin [Source:HGNC Symbol;Acc:HGNC:9498]	[more]

BLAST of Saposin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Saposin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Sap-r	5.570e-18	27.96	gene:FBgn0000416 transcript:FBtr0085714	[more]
Sap-r	6.973e-18	27.96	gene:FBgn0000416 transcript:FBtr0085713	[more]

BLAST of Saposin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sftpbb	1.732e-11	23.53	surfactant protein Bb [Source:NCBI gene;Acc:100001...	[more]
psap	2.583e-10	22.92	prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1]	[more]
psap	2.636e-10	22.92	prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1]	[more]
sftpba	2.748e-8	29.06	surfactant protein Ba [Source:ZFIN;Acc:ZDB-GENE-09...	[more]
psap	8.865e-8	30.59	prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1]	[more]

BLAST of Saposin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
psap	1.784e-17	26.73	prosaposin (variant Gaucher disease and variant me...	[more]
psap	1.830e-17	26.11	prosaposin (variant Gaucher disease and variant me...	[more]
psap	2.739e-17	26.73	prosaposin (variant Gaucher disease and variant me...	[more]
psap	4.083e-17	27.33	prosaposin (variant Gaucher disease and variant me...	[more]
psap	7.678e-16	25.97	prosaposin (variant Gaucher disease and variant me...	[more]

BLAST of Saposin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Psap	6.539e-13	21.89	prosaposin [Source:MGI Symbol;Acc:MGI:97783]	[more]
Psap	6.930e-13	21.89	prosaposin [Source:MGI Symbol;Acc:MGI:97783]	[more]
Psap	7.203e-13	21.89	prosaposin [Source:MGI Symbol;Acc:MGI:97783]	[more]
Psap	7.343e-13	21.89	prosaposin [Source:MGI Symbol;Acc:MGI:97783]	[more]
Psap	7.612e-13	21.89	prosaposin [Source:MGI Symbol;Acc:MGI:97783]	[more]

BLAST of Saposin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P26779\|SAP_BOVIN	2.187e-16	23.50	Prosaposin OS=Bos taurus OX=9913 GN=PSAP PE=1 SV=3	[more]
sp\|O13035\|SAP_CHICK	1.884e-15	26.02	Prosaposin OS=Gallus gallus OX=9031 GN=PSAP PE=1 S...	[more]
sp\|P07602\|SAP_HUMAN	6.811e-14	21.20	Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV...	[more]
sp\|Q61207\|SAP_MOUSE	5.325e-12	21.89	Prosaposin OS=Mus musculus OX=10090 GN=Psap PE=1 S...	[more]
sp\|P10960\|SAP_RAT	4.584e-11	21.89	Prosaposin OS=Rattus norvegicus OX=10116 GN=Psap P...	[more]

BLAST of Saposin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4Y2NU07	7.993e-23	24.38	Prosaposin OS=Araneus ventricosus OX=182803 GN=PSA...	[more]
A0A4Y2NSQ4	1.227e-22	26.55	Prosaposin OS=Araneus ventricosus OX=182803 GN=PSA...	[more]
A0A267GYV9	7.684e-21	26.38	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1I8G4W7	2.893e-20	26.38	Uncharacterized protein OS=Macrostomum lignano OX=...	[more]
A0A1E1X7J6	4.976e-20	29.58	Putative saposin OS=Amblyomma aureolatum OX=187763...	[more]

BLAST of Saposin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
psap	5.301e-12	25.52	prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1]	[more]
psap	1.643e-9	30.00	prosaposin [Source:ZFIN;Acc:ZDB-GENE-020108-1]	[more]
sftpbb	1.408e-8	26.83	surfactant protein Bb [Source:NCBI gene;Acc:100001...	[more]
sftpba	4.952e-8	24.60	prosaposin-like [Source:NCBI gene;Acc:103040133]	[more]
ENSAMXT00000035797.1	7.773e-7	33.78	prosaposin-like [Source:NCBI gene;Acc:107197742]	[more]

BLAST of Saposin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Saposin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Saposin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO39178	4.168e-17	28.57	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31455	3.161e-12	24.48	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38309	4.988e-11	24.55	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Saposin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
sftpbb	6.201e-12	21.88	prosaposin-like [Source:NCBI gene;Acc:101161410]	[more]
sftpbb	7.756e-12	21.88	prosaposin-like [Source:NCBI gene;Acc:101161410]	[more]
psap	2.862e-10	23.45	prosaposin [Source:NCBI gene;Acc:101163196]	[more]

BLAST of Saposin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000019975.1	0.000e+0	99.62	SMESG000019975.1	[more]
SMESG000019976.1	1.486e-58	55.42	SMESG000019976.1	[more]
SMESG000019977.1	2.975e-24	38.46	SMESG000019977.1	[more]
SMESG000019973.1	7.974e-14	23.97	SMESG000019973.1	[more]
SMESG000020046.1	1.138e-11	23.01	SMESG000020046.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30016252 ID=SMED30016252|Name=Saposin|organism=Schmidtea mediterranea sexual|type=transcript|length=1115bp
TGCATTTTCATTATCAATATTAATAAACAATGCACAGTTACCGTACGTAG
AAACGCAAGTCCGTCCAACGTACATCACAACCCGATAAACTTTGTATTAC
AGAGTGCAAAATCTGCCATTATAAATAAAAATATTTTCAACAATAGTCTC
ATTCAAAAATGAAAATTTGCTATTTTTTAGGAATATTTCTTTTATCAAGC
ATTCATTGCGTATATGAGAAAATTAATCCAATTTCTCCAGGAGAGAAGAA
ATTGCTATGTACTCTTTTCCCGGAAACATTTCGAGAGAAGTGCTCAGAGT
ATTCTCCCACGAAACCTATTGGGATAAGTGAGATTGAAATTCATGCTCAA
ATAAAAATAAAAATGACTAATTCAGAAGAAAATAAATCGTTTGGGTGTGA
TGTCTGTAAGAAACTTATTCAACAAGTCATAGATGCCATTGGTAGCAACC
ATTCAAAAGATGTTGTTCGAAAAGAGTTAGAAAAGGTTTGTGATGGACTG
CCATTTGTTTGGAAACCGGTTTGTAAAGATATCGTAGACAAATTTGCAGA
TACAATTGTGGACGAAATCGTGAAAAATCTACCAGCCGACAAAATTTGCC
AAAACATTGGATTGTGTAGTTCCTTAGCAGCTATTAGCCCACCGAGGGAA
AAATCGGTTTTGTGTTGGATTTGCAGTCAAATAATCGAGGAAATATTTAA
ACAAATTGGTGAAAGACGAGTGGCGGAAGAAATAAAAAGAGCTCTTGAAG
GGGTCTGCAACATTTTCCCGGTGATTTACAGACATCAATGCAATGAATTC
GTAGATAGATATGCAGTTGAAATTGTCAAGCTTATTTTAGAAGGCAAAGC
CGGAGGAGTGATTTGCAGTGCCTTGCAACTTTGTGAAACCAGAAATTATC
CTACCATCAAATCAAAGGATACAATGTACTTCCTCCCAAAATTCGCCCTA
AATTGATCCAAGAAACAATAAAAAATAACTAACTTTTTTAAAACATAATA
TTTCAGTAGTTATTTCATTTTAATAAATTTAATTTGTAACTTATTATCAT
TTATTTTTCCTGTCGTTGATTATCATCTTTGTAGTTATTTAAATTTTTTA
AAATTTATTTTTCGG

protein sequence of SMED30016252-orf-1

>SMED30016252-orf-1 ID=SMED30016252-orf-1|Name=SMED30016252-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=266bp
MKICYFLGIFLLSSIHCVYEKINPISPGEKKLLCTLFPETFREKCSEYSP
TKPIGISEIEIHAQIKIKMTNSEENKSFGCDVCKKLIQQVIDAIGSNHSK
DVVRKELEKVCDGLPFVWKPVCKDIVDKFADTIVDEIVKNLPADKICQNI
GLCSSLAAISPPREKSVLCWICSQIIEEIFKQIGERRVAEEIKRALEGVC
NIFPVIYRHQCNEFVDRYAVEIVKLILEGKAGGVICSALQLCETRNYPTI
KSKDTMYFLPKFALN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0002032	epidermal cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR008373	Saposin
IPR008139	SaposinB_dom
IPR007856	SapB_1
IPR011001	Saposin-like
IPR008138	SapB_2

Vocabulary: **biological process**
Term	Definition
GO:0006665	sphingolipid metabolic process
GO:0006629	lipid metabolic process

Vocabulary: **cellular component**
Term	Definition
GO:0005764	lysosome

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR008373	Saposin	PRINTS	PR01797	SAPOSIN	coord: 80..100 score: 23.81 coord: 198..220 score: 33.54 coord: 129..147 score: 15.04 coord: 220..243 score: 19.64
IPR008139	Saposin B type domain	SMART	SM00741	sapb_4	coord: 78..153 e-value: 2.3E-19 score: 80.3 coord: 167..242 e-value: 2.8E-15 score: 66.8
IPR008139	Saposin B type domain	PROSITE	PS50015	SAP_B	coord: 165..246 score: 17.224
IPR008139	Saposin B type domain	PROSITE	PS50015	SAP_B	coord: 76..157 score: 18.285
None	No IPR available	GENE3D	G3DSA:1.10.225.10		coord: 164..244 e-value: 1.1E-16 score: 63.1
None	No IPR available	GENE3D	G3DSA:1.10.225.10		coord: 76..157 e-value: 2.4E-19 score: 71.6
None	No IPR available	PANTHER	PTHR11480	SAPOSIN-RELATED	coord: 65..245
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..20 score: 0.663
IPR007856	Saposin-like type B, region 1	PFAM	PF05184	SapB_1	coord: 80..115 e-value: 3.1E-8 score: 33.5 coord: 168..204 e-value: 1.4E-6 score: 28.1
IPR008138	Saposin B type, region 2	PFAM	PF03489	SapB_2	coord: 121..153 e-value: 3.1E-9 score: 36.8 coord: 210..242 e-value: 2.1E-6 score: 27.7
IPR011001	Saposin-like	SUPERFAMILY	SSF47862	Saposin	coord: 166..244
IPR011001	Saposin-like	SUPERFAMILY	SSF47862	Saposin	coord: 78..155

Main menu

Saposin

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Owlery

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