Kazal-type serine protease inhibitor domain-containing protein 1

Overview


Name	Kazal-type serine protease inhibitor domain-containing protein 1
Smed ID	SMED30016206
Length (bp)	883

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Kazal-type serine protease inhibitor domain-containing protein 1 (SMED30016206) t-SNE clustered cells

Violin plots show distribution of expression levels for Kazal-type serine protease inhibitor domain-containing protein 1 (SMED30016206) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Kazal-type serine protease inhibitor domain-containing protein 1 (SMED30016206) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30016206

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
cephalic ganglia	SMED30016206	SMESG000033854.1	dd_Smed_v4_4437_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30016206	SMESG000033854.1	dd_Smed_v4_4437_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30016206	SMESG000033854.1	dd_Smed_v4_4437_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30016206	SMESG000033854.1	Contig42716	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30016206	SMESG000033854.1	Contig42716	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
enteric muscle cell	SMED30016206	SMESG000033854.1	dd_Smed_v4_4437_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018
muscle cell	SMED30016206	SMESG000033854.1	dd_Smed_v4_4437_0_1	dd_Smed_v4	PMID:30962434 Cote et al., 2019

Note: Hover over icons to view figure legend

Homology

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Human
Match: IGFBP7 (insulin like growth factor binding protein 7 [Source:HGNC Symbol;Acc:HGNC:5476])

HSP 1 Score: 92.0485 bits (227), Expect = 3.747e-21
Identity = 61/187 (32.62%), Postives = 90/187 (48.13%), Query Frame = 3

Query:  237 FCGDNMECIKRNDIDSVKYES-------QSVCVCQLKGLICGSDGITY-TPCQFAAASMKLK------INQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPG---ATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDG--FATKKITLV 740
            +C   MEC+K       K  +         VCVC+ +  +CGSDG TY + CQ  AAS + +      I Q   G C+  P I++       V G++  + CEV G P P + W     G       + LPGD + ++I  RGGPEK  +T ++ ++    +  G YEC A+   G   A+ KIT+V
Sbjct:   80 YCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVV 266

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Human
Match: IGFBP7 (insulin like growth factor binding protein 7 [Source:HGNC Symbol;Acc:HGNC:5476])

HSP 1 Score: 92.0485 bits (227), Expect = 3.792e-21
Identity = 61/187 (32.62%), Postives = 90/187 (48.13%), Query Frame = 3

Query:  237 FCGDNMECIKRNDIDSVKYES-------QSVCVCQLKGLICGSDGITY-TPCQFAAASMKLK------INQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPG---ATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDG--FATKKITLV 740
            +C   MEC+K       K  +         VCVC+ +  +CGSDG TY + CQ  AAS + +      I Q   G C+  P I++       V G++  + CEV G P P + W     G       + LPGD + ++I  RGGPEK  +T ++ ++    +  G YEC A+   G   A+ KIT+V
Sbjct:   80 YCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVV 266

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Human
Match: KAZALD1 (Kazal type serine peptidase inhibitor domain 1 [Source:HGNC Symbol;Acc:HGNC:25460])

HSP 1 Score: 88.9669 bits (219), Expect = 6.193e-20
Identity = 54/179 (30.17%), Postives = 84/179 (46.93%), Query Frame = 3

Query:  219 SKIWHGFCGDNMECIKRNDIDSVKYE-SQSVCVCQLKGLICGSDGITYTP-CQF---AAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            S  ++G CG+ +EC      D  + E  + +C C+ +  +CGSDG TY+  C+    A A     +   H GPC++ P+I+S       V G      CEV  +P+ +++W            LPGD   +S+  RGGP++  +T +LQI   +   EG Y CL     G      +L 
Sbjct:   95 SAHFYGHCGEQLECRLDTGGDLSRGEVPEPLCACRSQSPLCGSDGHTYSQICRLQEAARARPDANLTVAHPGPCESGPQIVSHPYDTWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQ----LPGDDPHISVQFRGGPQRFEVTGWLQIQAVRPSDEGTYRCLGRNALGQVEAPASLT 269

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Human
Match: IGFBPL1 (insulin like growth factor binding protein like 1 [Source:HGNC Symbol;Acc:HGNC:20081])

HSP 1 Score: 78.5666 bits (192), Expect = 3.175e-16
Identity = 48/163 (29.45%), Postives = 82/163 (50.31%), Query Frame = 3

Query:  294 ESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLK-----------INQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQW--FYTAPGATEP-QALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            E   +CVC  +G +CGSDG +Y     +  +++L+           +++  DGPC+  P ++    S + V G++  + CEV+  P P + W     +P  T+  + LPGD   +++ VRGGP     TA++ I   + + EG Y+C A  + G A    T+ 
Sbjct:  101 EGTGLCVCAQRGTVCGSDGRSYP----SVCALRLRARHTPRAHPGHLHKARDGPCEFAPVVVVPPRSVHNVTGAQVGLSCEVRAVPTPVITWRKVTKSPEGTQALEELPGDHVNIAVQVRGGPSDHEATAWILINPLRKEDEGVYQCHAANMVGEAESHSTVT 259

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Fly
Match: sls (gene:FBgn0086906 transcript:FBtr0332677)

HSP 1 Score: 48.521 bits (114), Expect = 6.325e-6
Identity = 32/100 (32.00%), Postives = 51/100 (51.00%), Query Frame = 3

Query:  468 VVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQKILAWNY 767
            V+ G    + C+V G P P V+W++ A   TE       ++E +IS     + ++    LQIT+   ++EG YEC+AT   G +  K  +   KI A+ Y
Sbjct: 6954 VMDGEALLLTCQVTGKPTPKVEWYHNAEKITE-------NKETTIS-----QDLQGVCQLQITEVFPENEGQYECVATNKIGKSVSKTNV---KIQAFEY 7038

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Fly
Match: sls (gene:FBgn0086906 transcript:FBtr0332683)

HSP 1 Score: 48.1358 bits (113), Expect = 7.004e-6
Identity = 32/100 (32.00%), Postives = 51/100 (51.00%), Query Frame = 3

Query:  468 VVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQKILAWNY 767
            V+ G    + C+V G P P V+W++ A   TE       ++E +IS     + ++    LQIT+   ++EG YEC+AT   G +  K  +   KI A+ Y
Sbjct: 6954 VMDGEALLLTCQVTGKPTPKVEWYHNAEKITE-------NKETTIS-----QDLQGVCQLQITEVFPENEGQYECVATNKIGKSVSKTNV---KIQAFEY 7038

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Fly
Match: sls (gene:FBgn0086906 transcript:FBtr0332679)

HSP 1 Score: 48.1358 bits (113), Expect = 7.164e-6
Identity = 32/100 (32.00%), Postives = 51/100 (51.00%), Query Frame = 3

Query:  468 VVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQKILAWNY 767
            V+ G    + C+V G P P V+W++ A   TE       ++E +IS     + ++    LQIT+   ++EG YEC+AT   G +  K  +   KI A+ Y
Sbjct: 6954 VMDGEALLLTCQVTGKPTPKVEWYHNAEKITE-------NKETTIS-----QDLQGVCQLQITEVFPENEGQYECVATNKIGKSVSKTNV---KIQAFEY 7038

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Fly
Match: sls (gene:FBgn0086906 transcript:FBtr0332676)

HSP 1 Score: 48.1358 bits (113), Expect = 7.365e-6
Identity = 32/100 (32.00%), Postives = 51/100 (51.00%), Query Frame = 3

Query:  468 VVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQKILAWNY 767
            V+ G    + C+V G P P V+W++ A   TE       ++E +IS     + ++    LQIT+   ++EG YEC+AT   G +  K  +   KI A+ Y
Sbjct: 6954 VMDGEALLLTCQVTGKPTPKVEWYHNAEKITE-------NKETTIS-----QDLQGVCQLQITEVFPENEGQYECVATNKIGKSVSKTNV---KIQAFEY 7038

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Fly
Match: sls (gene:FBgn0086906 transcript:FBtr0332675)

HSP 1 Score: 48.1358 bits (113), Expect = 7.366e-6
Identity = 32/100 (32.00%), Postives = 51/100 (51.00%), Query Frame = 3

Query:  468 VVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQKILAWNY 767
            V+ G    + C+V G P P V+W++ A   TE       ++E +IS     + ++    LQIT+   ++EG YEC+AT   G +  K  +   KI A+ Y
Sbjct: 6954 VMDGEALLLTCQVTGKPTPKVEWYHNAEKITE-------NKETTIS-----QDLQGVCQLQITEVFPENEGQYECVATNKIGKSVSKTNV---KIQAFEY 7038

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Zebrafish
Match: kazald3 (Kazal-type serine peptidase inhibitor domain 3 [Source:ZFIN;Acc:ZDB-GENE-050208-155])

HSP 1 Score: 104.375 bits (259), Expect = 8.668e-26
Identity = 83/225 (36.89%), Postives = 116/225 (51.56%), Query Frame = 3

Query:   72 KDMDCLHCDLDKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECI-KRNDIDSVKYESQSVCVCQLKGLICGSDGITY-TPCQF-AAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITL 737
            +  +C  C  + CPPA  C AGLV D CGCC  C   EGQ C         +++G CG++MEC   R+D++    E ++ CVC  +  +CGSDG TY   C++  AA +K  +N   DGPC+T P I     +   V GS    LCEV  FP+  V+W            LPGD   +S+  RGGP+K  L+++LQI +      G Y+C+A    G  +    L
Sbjct:   52 RTRECEECVPELCPPALGCRAGLVMDVCGCCSQCANLEGQTCD---PGQRSVYYGLCGEDMECRPDRSDVE----EPEAQCVCLSQDPLCGSDGQTYMNVCKYKEAAYLKPGLNVS-DGPCRTEPIIKVAPHNLVNVTGSSIAFLCEVFAFPMALVEWRKEGKEVI----LPGDDPHISVQSRGGPQKYELSSWLQIEEAGQTDSGTYKCIARNELGHVSATAIL 264

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Zebrafish
Match: igfbp7 (insulin-like growth factor binding protein 7 [Source:ZFIN;Acc:ZDB-GENE-040426-2423])

HSP 1 Score: 88.1965 bits (217), Expect = 4.435e-20
Identity = 71/222 (31.98%), Postives = 112/222 (50.45%), Query Frame = 3

Query:   84 CLHCDLDKCPP--AGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITY-TPCQFAAASM------KLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFAT 722
            C  CD  +C P  A  C++G +RD CGCCE+C   EG+ C        +     CG  +EC+K +     K     +CVC+    +CG+DG  Y + C   AAS       + +I   + G C   P+I++       + GS+  + CE  G P P + W   + G+ +P  LPGD + +++  RGGPEK ++T ++ I+      +G+YEC A+   G A+
Sbjct:   22 CGSCDRTQCAPLPAQGCSSGTLRDSCGCCELCAAAEGEPCGGRGVSARR-----CGSGLECVKPD-----KKSKSGICVCKSGVPVCGTDGRNYNSGCALRAASARALQEKQPEIRVHNTGRCAQGPEIVTPPGEVWNITGSQVFLSCEAIGVPTPVLTWRKVSGGSEKPVPLPGDKDNLAVQTRGGPEKHQVTGWVLISPLTKAEDGSYECHASNTQGEAS 233

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Zebrafish
Match: igfbp7 (insulin-like growth factor binding protein 7 [Source:ZFIN;Acc:ZDB-GENE-040426-2423])

HSP 1 Score: 88.1965 bits (217), Expect = 4.540e-20
Identity = 71/222 (31.98%), Postives = 112/222 (50.45%), Query Frame = 3

Query:   84 CLHCDLDKCPP--AGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITY-TPCQFAAASM------KLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFAT 722
            C  CD  +C P  A  C++G +RD CGCCE+C   EG+ C        +     CG  +EC+K +     K     +CVC+    +CG+DG  Y + C   AAS       + +I   + G C   P+I++       + GS+  + CE  G P P + W   + G+ +P  LPGD + +++  RGGPEK ++T ++ I+      +G+YEC A+   G A+
Sbjct:   22 CGSCDRTQCAPLPAQGCSSGTLRDSCGCCELCAAAEGEPCGGRGVSARR-----CGSGLECVKPD-----KKSKSGICVCKSGVPVCGTDGRNYNSGCALRAASARALQEKQPEIRVHNTGRCAQGPEIVTPPGEVWNITGSQVFLSCEAIGVPTPVLTWRKVSGGSEKPVPLPGDKDNLAVQTRGGPEKHQVTGWVLISPLTKAEDGSYECHASNTQGEAS 233

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Zebrafish
Match: kazald2 (Kazal-type serine peptidase inhibitor domain 2 [Source:ZFIN;Acc:ZDB-GENE-070928-14])

HSP 1 Score: 85.1149 bits (209), Expect = 1.023e-18
Identity = 72/223 (32.29%), Postives = 106/223 (47.53%), Query Frame = 3

Query:   93 CDLDKCPPAGV---CNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTP-CQFAAASMKLK----INQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITL 737
            C  ++CP       C AGLVRD+CGCC  CG +EGQL  D   ++   ++G C + + C  R    ++  + ++VCVC  +  +CGSDG TY   CQ  AA  K      +   H GPC+T+P I          +GS     CEV  +P+ ++QW        +  + P D    ++  RGGP +  +T +LQI        G Y C+A    G  +    L
Sbjct:   43 CHPERCPDVRQLQGCPAGLVRDQCGCCWECGNDEGQL-CDPEPRSGLAFYGRCAEGLRC--RAPRRNLAGQPRAVCVCGKQEALCGSDGKTYKNICQLQAAQHKQSKGPMLTMVHHGPCKTKPVITYAPRDIITSKGSDVMFSCEVSSYPLASIQWSKDG----DVISFPADDSSTAVQARGGPRRFEMTGWLQIQGVGPSDAGVYTCIARNAFGEVSASARL 258

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Xenopus
Match: plcb1 (phospholipase C beta 1 [Source:Xenbase;Acc:XB-GENE-6045753])

HSP 1 Score: 104.76 bits (260), Expect = 1.044e-25
Identity = 80/225 (35.56%), Postives = 116/225 (51.56%), Query Frame = 3

Query:   84 CLHCDLDKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYES--QSVCVCQLKGLICGSDGITYTP-CQF---AAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            C  C+ ++CP    C AG+VRD C CC  C   EGQ+C      N+  ++G CGDN+EC  + D+  +++    +  CVC     +CGSDG TY+  C+F   A A     +   HDGPC++ P+I+S       + G      CEV  +P+ +++W     GA     LPGD   +S+  RGGP+K  +T +LQI   +   EG Y+CLA    G      TL 
Sbjct:   52 CTDCNPEECPLPRGCLAGVVRDHCDCCLECANLEGQICD---LDNTNHFYGKCGDNLEC--QLDMGDLRHGEVPEPQCVCVFNTAVCGSDGKTYSQLCKFKEVANAHPGANLTVVHDGPCESAPQILSPPYDIWNITGKDAIFGCEVFAYPMASIEW--RKDGAE--MLLPGDDPHISVQFRGGPQKYEVTGWLQIQSVRTSDEGTYKCLAKNKIGEVMAGATLT 267

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Xenopus
Match: guca1b (guanylate cyclase activator 1B [Source:Xenbase;Acc:XB-GENE-5838913])

HSP 1 Score: 88.5817 bits (218), Expect = 6.769e-20
Identity = 59/194 (30.41%), Postives = 91/194 (46.91%), Query Frame = 3

Query:  240 CGDNMECIKRNDID---SVKYESQSVCVCQLKGLICGSDGITYT-PCQFAAASMKLK------INQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQW---FYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQKILAWNYKRIRN 782
            C   M C+ R       S   +   VC+C+  G +CGSDG TY+  C     S K +      I++ HDG C+  P II+       V GS+  + CEV+  P P + W     +  G    + LPGD   +++ VRGGP +   T ++ I+    + EG Y+C AT + G      ++   K+   N +RI+ 
Sbjct:   77 CAPGMVCVSRPSFGTGASSFSDGTGVCLCEEDGAVCGSDGRTYSSACVLRLQSWKSQHQGTGSIHKTHDGECKFAPLIIASPRKIRNVTGSQVYLSCEVKAVPTPIITWKKVTESPQGIKLFEELPGDRINVAVQVRGGPSRHECTGWVMISPLTKEDEGTYQCHATNMVGETWADGSI---KVTEHNARRIKR 267

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Mouse
Match: Igfbp7 (insulin-like growth factor binding protein 7 [Source:MGI Symbol;Acc:MGI:1352480])

HSP 1 Score: 97.0561 bits (240), Expect = 4.185e-23
Identity = 64/189 (33.86%), Postives = 93/189 (49.21%), Query Frame = 3

Query:  231 HGFCGDNMECIKRNDIDSVKY-------ESQSVCVCQLKGLICGSDGITY-TPCQFAAASMKLK------INQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTA---PGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFAT--KKITLV 740
             G C   MEC+K       K         + +VCVC+ +  +CGS+GITY + CQ  AAS++ +      I Q   G C+  P I++       V G+K  + CEV G P P + W        G    + LPGD E ++I  RGGPEK  +T ++ ++    +  G YEC A+   G A+   KIT+V
Sbjct:   78 RGHCAPGMECVKSRKRRKGKAGAAAGGPATLAVCVCKSRYPVCGSNGITYPSGCQLRAASLRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAKVFLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASAAAKITVV 266

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Mouse
Match: Kazald1 (Kazal-type serine peptidase inhibitor domain 1 [Source:MGI Symbol;Acc:MGI:2147606])

HSP 1 Score: 95.9005 bits (237), Expect = 1.975e-22
Identity = 79/229 (34.50%), Postives = 112/229 (48.91%), Query Frame = 3

Query:   69 AKDMDCLHCDLDKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYE-SQSVCVCQLKGLICGSDGITYTP-CQF---AAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            A+   C  C  ++C     C AG VRD CGCC  C   EGQLC    + N   ++G CG+ +EC      D  + E  + +CVC+ +  +CGSDG TY   C+    A A +   +   H GPC++ P+I+S   +   V G      CEV  +P+ +++W            LPGD   +S+  RGGP+K  +T +LQI   +   EG Y CLA    G A    TL 
Sbjct:   55 AEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSAN---FYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAARARLDANLTVVHPGPCESEPQILSQPHNIWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQ----LPGDDPHISVQFRGGPQKFEVTGWLQIQALRPSDEGTYRCLARNALGQAEASATLT 276

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Query:   69 AKDMDCLHCDLDKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYE-SQSVCVCQLKGLICGSDGITYTP-CQF---AAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            A+   C  C  ++C     C AG VRD CGCC  C   EGQLC    + N   ++G CG+ +EC      D  + E  + +CVC+ +  +CGSDG TY   C+    A A +   +   H GPC++ P+I+S   +   V G      CEV  +P+ +++W            LPGD   +S+  RGGP+K  +T +LQI   +   EG Y CLA    G A    TL 
Sbjct:   55 AEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSAN---FYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAARARLDANLTVVHPGPCESEPQILSQPHNIWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQ----LPGDDPHISVQFRGGPQKFEVTGWLQIQALRPSDEGTYRCLARNALGQAEASATLT 276

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Mouse
Match: Igfbpl1 (insulin-like growth factor binding protein-like 1 [Source:MGI Symbol;Acc:MGI:1933198])

HSP 1 Score: 83.5741 bits (205), Expect = 3.034e-18
Identity = 51/177 (28.81%), Postives = 82/177 (46.33%), Query Frame = 3

Query:  240 CGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTP-------CQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQW--FYTAPGATEP-QALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            CG  + C  R        E   +CVC  +G +CGSDG +Y+         + A  +    +++  DGPC+  P ++      + V G++  + CEV+  P P + W     +P  TE  + LPGD   +++ VRGGP     T+++ I   + + EG Y C A    G A    T+ 
Sbjct:   77 CGPGLVCASR--ASGTAPEGTGLCVCAQRGAVCGSDGRSYSSICALRLRARHAPRAHHGHLHKARDGPCEFAPVVLMPPRDIHNVTGTQVFLSCEVKAVPTPVITWKKVKHSPEGTEGLEELPGDHVNIAVQVRGGPSDHETTSWILINPLRKEDEGVYHCHAANAIGEAQSHGTVT 251

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Mouse
Match: Igfbp7 (insulin-like growth factor binding protein 7 [Source:MGI Symbol;Acc:MGI:1352480])

HSP 1 Score: 80.8777 bits (198), Expect = 4.460e-17
Identity = 67/220 (30.45%), Postives = 96/220 (43.64%), Query Frame = 3

Query:  231 HGFCGDNMECIKRNDIDSVKY-------ESQSVCVCQLKGLICGSDGITY-TPCQFAAASMKLK------INQKHDGPCQ-------TRPKIIS---------FSDSQNV---------------VQGSKHTILCEVQGFPIPNVQWFYTA---PGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFAT--KKITLV 740
             G C   MEC+K       K         + +VCVC+ +  +CGS+GITY + CQ  AAS++ +      I Q   G C+       T+P   S         F D  +                V G+K  + CEV G P P + W        G    + LPGD E ++I  RGGPEK  +T ++ ++    +  G YEC A+   G A+   KIT+V
Sbjct:   78 RGHCAPGMECVKSRKRRKGKAGAAAGGPATLAVCVCKSRYPVCGSNGITYPSGCQLRAASLRAESRGEKAITQVSKGTCEQGSLIWDTQPAQRSHNPQVENRCFRDKHSREQGPSIVTPPKDIWNVTGAKVFLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASAAAKITVV 297

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|G4V4G1|IGFBP_CUPSA (Insulin-like growth factor-binding protein-related protein 1 OS=Cupiennius salei OX=6928 PE=2 SV=1)

HSP 1 Score: 103.99 bits (258), Expect = 5.555e-25
Identity = 83/229 (36.24%), Postives = 120/229 (52.40%), Query Frame = 3

Query:   75 DMDCLHCDLDKC-PPAGVCNAGLVRDKXXXXXXXXXXXXXX-XSDY-SAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITY-TPCQFAAASMKLK--INQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFY-TAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            +  C  C+ +KC PP+  C AGLV+D CGCC VCG  EG+L   D+         HG CG+ +EC  R D+ +     +++CVC     +CGSDG TY   CQ   A  K +  +   H GPC++ PKI S  +  +   G    + CE  G+PIP  +W      G T P  LP D  ++S+  RGGP K  +T++LQ+   Q K +  Y C+A   +G ++    +V
Sbjct:   18 ERKCGECNPEKCQPPSEECLAGLVKDLCGCCYVCGRREGELCDGDFLPIPYRNRGHGPCGEYLECRPRTDL-APGDPPEAMCVCLKTETLCGSDGKTYQNECQLTEARYKQRDGLRAMHRGPCKSAPKITSPPEEASNYTGGNIAMSCEATGWPIPVFEWRVDIGDGNTIP--LPSDDPKVSVQSRGGPSKYEVTSWLQLLSIQPKDDATYWCIAKNDEGESSAAARVV 243

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q61581|IBP7_MOUSE (Insulin-like growth factor-binding protein 7 OS=Mus musculus OX=10090 GN=Igfbp7 PE=1 SV=3)

HSP 1 Score: 96.6709 bits (239), Expect = 3.457e-22
Identity = 64/189 (33.86%), Postives = 93/189 (49.21%), Query Frame = 3

Query:  231 HGFCGDNMECIKRNDIDSVKY-------ESQSVCVCQLKGLICGSDGITY-TPCQFAAASMKLK------INQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTA---PGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFAT--KKITLV 740
             G C   MEC+K       K         + +VCVC+ +  +CGS+GITY + CQ  AAS++ +      I Q   G C+  P I++       V G+K  + CEV G P P + W        G    + LPGD E ++I  RGGPEK  +T ++ ++    +  G YEC A+   G A+   KIT+V
Sbjct:   77 RGHCAPGMECVKSRKRRKGKAGAAAGGPATLAVCVCKSRYPVCGSNGITYPSGCQLRAASLRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAKVFLSCEVIGIPTPVLIWNKVKRDHSGVQRTELLPGDRENLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASAAAKITVV 265

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q8BJ66|KAZD1_MOUSE (Kazal-type serine protease inhibitor domain-containing protein 1 OS=Mus musculus OX=10090 GN=Kazald1 PE=1 SV=2)

HSP 1 Score: 95.9005 bits (237), Expect = 1.382e-21
Identity = 79/229 (34.50%), Postives = 112/229 (48.91%), Query Frame = 3

Query:   69 AKDMDCLHCDLDKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYE-SQSVCVCQLKGLICGSDGITYTP-CQF---AAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            A+   C  C  ++C     C AG VRD CGCC  C   EGQLC    + N   ++G CG+ +EC      D  + E  + +CVC+ +  +CGSDG TY   C+    A A +   +   H GPC++ P+I+S   +   V G      CEV  +P+ +++W            LPGD   +S+  RGGP+K  +T +LQI   +   EG Y CLA    G A    TL 
Sbjct:   55 AEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSAN---FYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAARARLDANLTVVHPGPCESEPQILSQPHNIWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQ----LPGDDPHISVQFRGGPQKFEVTGWLQIQALRPSDEGTYRCLARNALGQAEASATLT 276

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q16270|IBP7_HUMAN (Insulin-like growth factor-binding protein 7 OS=Homo sapiens OX=9606 GN=IGFBP7 PE=1 SV=1)

HSP 1 Score: 92.0485 bits (227), Expect = 1.799e-20
Identity = 61/187 (32.62%), Postives = 90/187 (48.13%), Query Frame = 3

Query:  237 FCGDNMECIKRNDIDSVKYES-------QSVCVCQLKGLICGSDGITY-TPCQFAAASMKLK------INQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPG---ATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDG--FATKKITLV 740
            +C   MEC+K       K  +         VCVC+ +  +CGSDG TY + CQ  AAS + +      I Q   G C+  P I++       V G++  + CEV G P P + W     G       + LPGD + ++I  RGGPEK  +T ++ ++    +  G YEC A+   G   A+ KIT+V
Sbjct:   80 YCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVV 266

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q96I82|KAZD1_HUMAN (Kazal-type serine protease inhibitor domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KAZALD1 PE=1 SV=1)

HSP 1 Score: 88.9669 bits (219), Expect = 2.974e-19
Identity = 54/179 (30.17%), Postives = 84/179 (46.93%), Query Frame = 3

Query:  219 SKIWHGFCGDNMECIKRNDIDSVKYE-SQSVCVCQLKGLICGSDGITYTP-CQF---AAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            S  ++G CG+ +EC      D  + E  + +C C+ +  +CGSDG TY+  C+    A A     +   H GPC++ P+I+S       V G      CEV  +P+ +++W            LPGD   +S+  RGGP++  +T +LQI   +   EG Y CL     G      +L 
Sbjct:   95 SAHFYGHCGEQLECRLDTGGDLSRGEVPEPLCACRSQSPLCGSDGHTYSQICRLQEAARARPDANLTVAHPGPCESGPQIVSHPYDTWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQ----LPGDDPHISVQFRGGPQRFEVTGWLQIQAVRPSDEGTYRCLGRNALGQVEAPASLT 269

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. TrEMBL
Match: A0A4D6FZJ4 (Uncharacterized protein (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 409.453 bits (1051), Expect = 1.480e-142
Identity = 215/216 (99.54%), Postives = 215/216 (99.54%), Query Frame = 3

Query:  102 DKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQK 749
            DKCPPAGVCNAGLVRDKCGCCEVCGLEEGQLCSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGD EEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQK
Sbjct:    1 DKCPPAGVCNAGLVRDKCGCCEVCGLEEGQLCSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDPEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQK 216

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. TrEMBL
Match: C1LFW8 (Kazal-type serine protease inhibitor domain-containing protein 1 OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 171.785 bits (434), Expect = 3.418e-48
Identity = 91/229 (39.74%), Postives = 130/229 (56.77%), Query Frame = 3

Query:   81 DCLHCDLDKCPPAGVCNAGLVRDKX------XXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAA--SMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQA-LPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            +C  CD  KCPP   CN G VRDKC         E           D   K+   WHG CG ++EC  R DIDS    SQS+C C   G +CGSDGITY+ C+  A   S K KI    +GPCQT P +   + +Q VV+G+  T++CE +G+PIP + W++  P   + +  +PG+ +++++SVRGG E+    ++LQIT F L++EG Y C+A  + G   +  +LV
Sbjct:   40 ECQKCDRKKCPPITQCNVGTVRDKCGCCDICALEEAQLCNTPDDFKDGIIKSGITWHGICGTDLECRTRTDIDSKVIGSQSICYCVKLGKVCGSDGITYSKCKMNATIISSKGKIIPISEGPCQTVPSVKLTALNQTVVEGANVTLICEARGYPIPTITWYFNKPNRKQDKIQMPGNYKDVTVSVRGGTEETHTISYLQITSFTLEYEGEYVCMADNIVGIKAQGTSLV 268

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. TrEMBL
Match: A0A4Z2CQF2 (Insulin-like growth factor-binding protein-related protein OS=Schistosoma japonicum OX=6182 GN=EWB00_008378 PE=4 SV=1)

HSP 1 Score: 171.785 bits (434), Expect = 3.513e-48
Identity = 91/229 (39.74%), Postives = 130/229 (56.77%), Query Frame = 3

Query:   81 DCLHCDLDKCPPAGVCNAGLVRDKX------XXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAA--SMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQA-LPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            +C  CD  KCPP   CN G VRDKC         E           D   K+   WHG CG ++EC  R DIDS    SQS+C C   G +CGSDGITY+ C+  A   S K KI    +GPCQT P +   + +Q VV+G+  T++CE +G+PIP + W++  P   + +  +PG+ +++++SVRGG E+    ++LQIT F L++EG Y C+A  + G   +  +LV
Sbjct:   40 ECQKCDRKKCPPITQCNVGTVRDKCGCCDICALEEAQLCNTPDDFKDGIIKSGITWHGICGTDLECRTRTDIDSKVIGSQSICYCVKLGKVCGSDGITYSKCKMNATIISSKGKIIPISEGPCQTVPSVKLTALNQTVVEGANVTLICEARGYPIPTITWYFNKPNRKQDKIQMPGNYKDVTVSVRGGTEETHTISYLQITSFTLEYEGEYVCMADNIVGIKAQGTSLV 268

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. TrEMBL
Match: Q86EL8 (Clone ZZD204 mRNA sequence OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 171.785 bits (434), Expect = 4.880e-48
Identity = 91/229 (39.74%), Postives = 130/229 (56.77%), Query Frame = 3

Query:   81 DCLHCDLDKCPPAGVCNAGLVRDKX------XXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAA--SMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQA-LPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            +C  CD  KCPP   CN G VRDKC         E           D   K+   WHG CG ++EC  R DIDS    SQS+C C   G +CGSDGITY+ C+  A   S K KI    +GPCQT P +   + +Q VV+G+  T++CE +G+PIP + W++  P   + +  +PG+ +++++SVRGG E+    ++LQIT F L++EG Y C+A  + G   +  +LV
Sbjct:   46 ECQKCDRKKCPPITQCNVGTVRDKCGCCDICALEEAQLCNTPDDFKDGIIKSGITWHGICGTDLECRTRTDIDSKVIGSQSICYCVKLGKVCGSDGITYSKCKMNATIISSKGKIIPISEGPCQTVPSVKLTALNQTVVEGANVTLICEARGYPIPTITWYFNKPNRKQDKIQMPGNYKDVTVSVRGGTEETHTISYLQITSFTLEYEGEYVCMADNIVGIKAQGTSLV 274

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. TrEMBL
Match: A0A5K4EZV8 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 164.081 bits (414), Expect = 4.060e-45
Identity = 87/229 (37.99%), Postives = 133/229 (58.08%), Query Frame = 3

Query:   81 DCLHCDLDKCPPAGVCNAGLVRDKX---XXXXXXXXXXXXXXSDYS---AKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAA--SMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQA-LPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLV 740
            +C  CD  KC P   CN G+VRDKC     C +   +   + +D+     K    W+G CG ++EC KR DIDS   ESQS+C C   G +CGSDGITY+ C+  A   S    +    +GPCQT P +     +Q V++G+  T++CE +G+PIP + W++  P   + +  +PG+ +++++SVRGG E+    ++LQIT F L++EG Y C+A  + G   +  +LV
Sbjct:   51 ECNKCDRKKCSPIIQCNVGIVRDKCGCCDICALEEAQLCNIPNDFINGILKQGITWYGICGTDLECRKRTDIDSKIIESQSICYCVKSGKVCGSDGITYSKCKMNATIISSNGTVIPISEGPCQTVPSVKLTVLNQTVIEGTNVTLICEARGYPIPTINWYFNKPNQKQDKIQMPGNYKDVTVSVRGGTEETHTISYLQITSFTLEYEGEYICMADNIVGIKAQGTSLV 279

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Cavefish
Match: ENSAMXT00000019221.2 (kazal-type serine protease inhibitor domain-containing protein 1-like [Source:NCBI gene;Acc:111193183])

HSP 1 Score: 108.227 bits (269), Expect = 3.059e-27
Identity = 88/233 (37.77%), Postives = 126/233 (54.08%), Query Frame = 3

Query:   84 CLHCDLDKCP--PAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKR-NDIDSVKYESQSVCVCQLKGLICGSDGITY-TPCQFAAASMKLK--INQKHDGPCQTRPKIISFSDSQNVVQGSKHTIL--CEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDG--FATKKITLVYQKI 752
            C  CD  +CP  P+G C AGLVRD+CGCCE CG  EGQ C       S+ ++G CGD + C +R +    +  E +  CVC+ +G++CGSDG TY   CQ   AS KL+  + Q   GPC   P+II   D +N    + H I+  CEV  +P+PNV W            LPGD   +S+ VRGGP++  ++ +LQI   +    G Y C+     G   A+  ++++  +I
Sbjct:   40 CGECDRSRCPVVPSG-CPAGLVRDRCGCCEHCGNAEGQWCD---LDRSQEFYGRCGDGLRCQRRPSRARGLGAEPEPRCVCKSRGVVCGSDGWTYPNLCQLREASSKLETMLYQTAPGPCSAAPRIIR--DPKNSKNYTGHDIVFGCEVMAYPLPNVGW----KKKDSDHFLPGDDPHISVQVRGGPQRYTVSTWLQIHGLRQSDAGIYICIFHNALGEKSASAHLSVISNEI 262

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BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Cavefish
Match: igfbp7 (insulin like growth factor binding protein 7 [Source:NCBI gene;Acc:103034972])

HSP 1 Score: 96.2857 bits (238), Expect = 4.294e-23
Identity = 55/165 (33.33%), Postives = 79/165 (47.88%), Query Frame = 3

Query:  240 CGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITY-TPCQFAAASM------KLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDG 713
            C   +EC+K             VC C+    +CGSDG++Y T C+  AAS       K  I  +H G CQ  P I++       V GS+  + CE +G P P V W   +    +   LPGD + ++I  RGGPEK  +T ++ I     +  G+YEC A+   G
Sbjct:   68 CAPGLECVKSKKDKKGAGSRTGVCACKNDYEVCGSDGVSYGTACELKAASALAEAEGKTGIKVQHKGKCQKAPTIVTPPGEVWNVTGSQVFLSCEAKGIPTPVVTWNKISSDKKKMLLLPGDQDNLAIQTRGGPEKHEVTGWVLIFPLTTRDAGSYECHASNAKG 232

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Cavefish
Match: kazald3 (kazal-type serine protease inhibitor domain-containing protein 1-like [Source:NCBI gene;Acc:103023912])

HSP 1 Score: 94.7449 bits (234), Expect = 3.137e-22
Identity = 72/210 (34.29%), Postives = 97/210 (46.19%), Query Frame = 3

Query:   84 CLHCDLDKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECI----KRNDIDSVKYESQSVCVCQLKGLICGSDGITYTP-CQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLA 698
            C  C  + CP    C AGLVRD    C            D   +N +  +G CG+NMEC     +  D D    E+Q VCV Q    +CG+DG TY   C+F  A+         +GPC+T P I         V GS    LCEV  FP+  V+W            LPGD   +S+  RGGP+K  L+++LQI +   +  G Y+C+ 
Sbjct:   54 CEECVPELCPVTQGCRAGLVRD-ICGCCFECGNLEGQSCDLEDRNVR--YGVCGENMECKLEPGQVVDADGSVPEAQCVCVSQEP--LCGTDGKTYMNLCKFKEAAFSSPGLNVSEGPCKTVPVIKVPPRDLVNVTGSSVAFLCEVFAFPMALVEWRKDGNEVI----LPGDDPHISVQSRGGPQKYELSSWLQIEETTREDSGTYKCIT 254

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Cavefish
Match: kazald2 (kazal-type serine protease inhibitor domain-containing protein 1-like [Source:NCBI gene;Acc:103032746])

HSP 1 Score: 92.0485 bits (227), Expect = 3.473e-21
Identity = 56/178 (31.46%), Postives = 84/178 (47.19%), Query Frame = 3

Query:  234 GFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITY-TPCQFAAASMKL----KINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDG--FATKKITLVYQ 746
            G C + + C       + K E + VCVC  + ++CGSDG TY   CQ  AA  +L    K+   H GPC+ +P I         ++GS   + CEV  +P+  +QW     G      L GD +  ++  RGGP +  LT +LQI        G Y C A    G   A+ ++ ++Y+
Sbjct:   92 GRCAEGLRCKASRKDTTGKEEPKPVCVCSKQEMLCGSDGKTYENVCQLRAAQRRLGERQKLTMAHHGPCEAKPIITYAPRDIITLEGSDVLLSCEVSSYPLATIQWRKEGDGVF----LSGD-DSRAVQARGGPRRFELTGWLQIHGVGPSDAGVYTCAARNAFGEVSASARLRVMYR 264

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Cavefish
Match: igfbp7 (insulin like growth factor binding protein 7 [Source:NCBI gene;Acc:103034972])

HSP 1 Score: 86.2705 bits (212), Expect = 2.886e-19
Identity = 49/150 (32.67%), Postives = 73/150 (48.67%), Query Frame = 3

Query:  240 CGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITY-TPCQFAAASM------KLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQL 668
            C   +EC+K             VC C+    +CGSDG++Y T C+  AAS       K  I  +H G CQ  P I++       V GS+  + CE +G P P V W   +    +   LPGD + ++I  RGGPEK  +T ++ ++  +L
Sbjct:   68 CAPGLECVKSKKDKKGAGSRTGVCACKNDYEVCGSDGVSYGTACELKAASALAEAEGKTGIKVQHKGKCQKAPTIVTPPGEVWNVTGSQVFLSCEAKGIPTPVVTWNKISSDKKKMLLLPGDQDNLAIQTRGGPEKHEVTGWVLVSMLRL 217

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003933.1 (pep scaffold:Pmarinus_7.0:GL485953:1518:2923:1 gene:ENSPMAG00000003601.1 transcript:ENSPMAT00000003933.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.8398 bits (133), Expect = 3.934e-10
Identity = 31/92 (33.70%), Postives = 48/92 (52.17%), Query Frame = 3

Query:  471 VQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDG--FATKKITLV 740
            V GS     CEV GFP+  V+W     G  E   LP D   +++  RGGP++ ++T +LQI + +    G Y C A    G  +AT ++ ++
Sbjct:   18 VSGSDVVFGCEVSGFPMAFVEW--RREGVDE--LLPADDAHLAVQARGGPQRYQMTGWLQIHNVRPSDSGVYVCYARNRLGEAYATARLIII 105

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Medaka
Match: kazald3 (kazal-type serine protease inhibitor domain-containing protein 1 [Source:NCBI gene;Acc:101173870])

HSP 1 Score: 83.1889 bits (204), Expect = 5.442e-18
Identity = 79/219 (36.07%), Postives = 109/219 (49.77%), Query Frame = 3

Query:   93 CDLDKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTP-CQFAAASM---KLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITL 737
            CD + CP    C AGLV D+CGCC+ C   EGQ   D   +N  +++G CG  + C  + D +    E + VCVC+ +  +CGSDG TYT  CQF  A+     L+++ +  GPC+T P I     SQ    G      CEV  FP+  V+W            LPGD   +S+  RGGP K  L+++LQI   +    G Y C+A    G  +    L
Sbjct:   68 CDPELCPETRGCRAGLVPDRCGCCQECANLEGQA-CDPGDRN--LFYGLCGSGLRC--QGDPNPASGEEEEVCVCEEQEPVCGSDGTTYTNMCQFRQANFSGPNLQLSAR--GPCRTVPVIKVPPQSQLNGSGGSLLFFCEVFAFPMALVEWRKDGRDVV----LPGDDPHISVQSRGGPLKFELSSWLQIERAEQSDSGTYHCIARNDLGSVSASAVL 275

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000033854.1 (SMESG000033854.1)

HSP 1 Score: 440.654 bits (1132), Expect = 5.931e-158
Identity = 246/247 (99.60%), Postives = 247/247 (100.00%), Query Frame = 3

Query:    9 MKFQXXXXXXXXXXXXXXXXAKDMDCLHCDLDKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQK 749
            MKFQLTLISVISLITLAVVSAKDMDCLHC+LDKCPPAGVCNAGLVRDKCGCCEVCGLEEGQLCSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQK
Sbjct:    1 MKFQLTLISVISLITLAVVSAKDMDCLHCELDKCPPAGVCNAGLVRDKCGCCEVCGLEEGQLCSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQK 247

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000033854.1 (SMESG000033854.1)

HSP 1 Score: 429.098 bits (1102), Expect = 1.013e-153
Identity = 223/224 (99.55%), Postives = 224/224 (100.00%), Query Frame = 3

Query:   78 MDCLHCDLDKCPPAGVCNAGLVRDKXXXXXXXXXXXXXXXSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQK 749
            MDCLHC+LDKCPPAGVCNAGLVRDKCGCCEVCGLEEGQLCSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQK
Sbjct:    1 MDCLHCELDKCPPAGVCNAGLVRDKCGCCEVCGLEEGQLCSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSVCVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSDSQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISVRGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQK 224

[Close]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000051919.1 (SMESG000051919.1)

HSP 1 Score: 48.9062 bits (115), Expect = 2.780e-6
Identity = 32/115 (27.83%), Postives = 57/115 (49.57%), Query Frame = 3

Query:  432 RPKIISFSDSQNVVQ-GSKHTILCEVQGFPIPNVQWFYTA---PGATEPQALPGDSEEMSISVRGG------PEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQ 746
            +P I+  S    + + G   ++ C+VQG P+PNV+WF  +   P   +P     + +E+SI  +        P+   L     IT+   +H G Y+CLA+  +G A + I ++ +
Sbjct:  135 QPVIVDISARNFIAKPGENVSLFCKVQGQPLPNVRWFKNSEVLPIQDKPLH---NLDELSIRDKDTNQYVILPKVRYLVWQYNITNVNHEHSGEYKCLASNSEGIAQESIYVIVK 246

The following BLAST results are available for this feature:

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Human
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Celegans
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Fly
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Zebrafish
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Xenopus
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Mouse
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. UniProt/SwissProt
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. TrEMBL
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Cavefish
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Sea Lamprey
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Yeast
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Nematostella
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Medaka
BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Planmine SMEST

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
IGFBP7	3.747e-21	32.62	insulin like growth factor binding protein 7 [Sour...	[more]
IGFBP7	3.792e-21	32.62	insulin like growth factor binding protein 7 [Sour...	[more]
KAZALD1	6.193e-20	30.17	Kazal type serine peptidase inhibitor domain 1 [So...	[more]
IGFBPL1	3.175e-16	29.45	insulin like growth factor binding protein like 1 ...	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sls	6.325e-6	32.00	gene:FBgn0086906 transcript:FBtr0332677	[more]
sls	7.004e-6	32.00	gene:FBgn0086906 transcript:FBtr0332683	[more]
sls	7.164e-6	32.00	gene:FBgn0086906 transcript:FBtr0332679	[more]
sls	7.365e-6	32.00	gene:FBgn0086906 transcript:FBtr0332676	[more]
sls	7.366e-6	32.00	gene:FBgn0086906 transcript:FBtr0332675	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
kazald3	8.668e-26	36.89	Kazal-type serine peptidase inhibitor domain 3 [So...	[more]
igfbp7	4.435e-20	31.98	insulin-like growth factor binding protein 7 [Sour...	[more]
igfbp7	4.540e-20	31.98	insulin-like growth factor binding protein 7 [Sour...	[more]
kazald2	1.023e-18	32.29	Kazal-type serine peptidase inhibitor domain 2 [So...	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
plcb1	1.044e-25	35.56	phospholipase C beta 1 [Source:Xenbase;Acc:XB-GENE...	[more]
guca1b	6.769e-20	30.41	guanylate cyclase activator 1B [Source:Xenbase;Acc...	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Igfbp7	4.185e-23	33.86	insulin-like growth factor binding protein 7 [Sour...	[more]
Kazald1	1.975e-22	34.50	Kazal-type serine peptidase inhibitor domain 1 [So...	[more]
Kazald1	1.975e-22	34.50	Kazal-type serine peptidase inhibitor domain 1 [So...	[more]
Igfbpl1	3.034e-18	28.81	insulin-like growth factor binding protein-like 1 ...	[more]
Igfbp7	4.460e-17	30.45	insulin-like growth factor binding protein 7 [Sour...	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|G4V4G1\|IGFBP_CUPSA	5.555e-25	36.24	Insulin-like growth factor-binding protein-related...	[more]
sp\|Q61581\|IBP7_MOUSE	3.457e-22	33.86	Insulin-like growth factor-binding protein 7 OS=Mu...	[more]
sp\|Q8BJ66\|KAZD1_MOUSE	1.382e-21	34.50	Kazal-type serine protease inhibitor domain-contai...	[more]
sp\|Q16270\|IBP7_HUMAN	1.799e-20	32.62	Insulin-like growth factor-binding protein 7 OS=Ho...	[more]
sp\|Q96I82\|KAZD1_HUMAN	2.974e-19	30.17	Kazal-type serine protease inhibitor domain-contai...	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4D6FZJ4	1.480e-142	99.54	Uncharacterized protein (Fragment) OS=Schmidtea me...	[more]
C1LFW8	3.418e-48	39.74	Kazal-type serine protease inhibitor domain-contai...	[more]
A0A4Z2CQF2	3.513e-48	39.74	Insulin-like growth factor-binding protein-related...	[more]
Q86EL8	4.880e-48	39.74	Clone ZZD204 mRNA sequence OS=Schistosoma japonicu...	[more]
A0A5K4EZV8	4.060e-45	37.99	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000019221.2	3.059e-27	37.77	kazal-type serine protease inhibitor domain-contai...	[more]
igfbp7	4.294e-23	33.33	insulin like growth factor binding protein 7 [Sour...	[more]
kazald3	3.137e-22	34.29	kazal-type serine protease inhibitor domain-contai...	[more]
kazald2	3.473e-21	31.46	kazal-type serine protease inhibitor domain-contai...	[more]
igfbp7	2.886e-19	32.67	insulin like growth factor binding protein 7 [Sour...	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000003933.1	3.934e-10	33.70	pep scaffold:Pmarinus_7.0:GL485953:1518:2923:1 gen...	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
kazald3	5.442e-18	36.07	kazal-type serine protease inhibitor domain-contai...	[more]

BLAST of Kazal-type serine protease inhibitor domain-containing protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000033854.1	5.931e-158	99.60	SMESG000033854.1	[more]
SMESG000033854.1	1.013e-153	99.55	SMESG000033854.1	[more]
SMESG000051919.1	2.780e-6	27.83	SMESG000051919.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30016206 ID=SMED30016206|Name=Kazal-type serine protease inhibitor domain-containing protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=883bp
AATAAATCATGAAATTTCAACTTACTTTAATAAGTGTTATTTCTTTAATA
ACTCTGGCAGTTGTTTCTGCCAAGGATATGGACTGTTTGCATTGTGATCT
TGATAAGTGCCCACCAGCTGGAGTTTGCAATGCAGGTTTAGTTCGAGATA
AATGTGGATGTTGTGAGGTTTGTGGATTGGAAGAAGGACAACTTTGCAGT
GACTATTCGGCAAAAAACAGCAAAATCTGGCATGGATTCTGTGGAGATAA
CATGGAATGTATTAAAAGAAACGATATCGATTCAGTGAAATACGAATCCC
AAAGTGTCTGTGTTTGTCAATTGAAGGGATTGATCTGTGGCAGTGACGGA
ATTACTTATACCCCATGCCAATTTGCTGCTGCTTCAATGAAATTGAAGAT
TAATCAAAAACACGATGGACCATGCCAAACTCGCCCAAAAATCATTAGCT
TCAGTGACAGTCAAAATGTCGTTCAAGGATCCAAGCACACAATTCTCTGT
GAAGTTCAAGGATTCCCTATTCCCAATGTCCAATGGTTTTACACCGCCCC
AGGAGCAACTGAACCACAAGCTCTACCAGGTGATTCCGAAGAAATGAGCA
TCAGTGTGCGCGGTGGACCAGAAAAGATGCGCCTCACTGCTTTCTTGCAA
ATTACTGATTTCCAGTTGAAACACGAAGGCAATTACGAATGTCTCGCCAC
TGGTGTCGATGGATTCGCTACAAAAAAAATTACATTAGTGTATCAAAAAA
TTCTAGCTTGGAATTATAAACGGATCCGAAATTATTGATTAATTCATTGA
TCTTATTTTTCTTATCACAATTTATTGATTAGTTTTTCGTTGAAAAATTA
ATAAAATATAAAATTTTGAAAAAAAATGTTGAA

protein sequence of SMED30016206-orf-1

>SMED30016206-orf-1 ID=SMED30016206-orf-1|Name=SMED30016206-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=260bp
MKFQLTLISVISLITLAVVSAKDMDCLHCDLDKCPPAGVCNAGLVRDKCG
CCEVCGLEEGQLCSDYSAKNSKIWHGFCGDNMECIKRNDIDSVKYESQSV
CVCQLKGLICGSDGITYTPCQFAAASMKLKINQKHDGPCQTRPKIISFSD
SQNVVQGSKHTILCEVQGFPIPNVQWFYTAPGATEPQALPGDSEEMSISV
RGGPEKMRLTAFLQITDFQLKHEGNYECLATGVDGFATKKITLVYQKILA
WNYKRIRNY*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0003104	enteric muscle cell

Vocabulary: **INTERPRO**
Term	Definition
IPR003599	Ig_sub
IPR003598	Ig_sub2
IPR000867	IGFBP-like
IPR002350	Kazal_dom
IPR013783	Ig-like_fold
IPR007110	Ig-like_dom
IPR009030	Growth_fac_rcpt_cys_sf

Vocabulary: **cellular component**
Term	Definition
GO:0005576	extracellular region

Vocabulary: **molecular function**
Term	Definition
GO:0005520	insulin-like growth factor binding
GO:0005515	protein binding

Vocabulary: **biological process**
Term	Definition
GO:0001558	regulation of cell growth

Main menu

Kazal-type serine protease inhibitor domain-containing protein 1

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Owlery

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