Alpha-1-antiproteinase 2

Overview
NameAlpha-1-antiproteinase 2
Smed IDSMED30016156
Length (bp)1356
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Alpha-1-antiproteinase 2 (SMED30016156) t-SNE clustered cells

Violin plots show distribution of expression levels for Alpha-1-antiproteinase 2 (SMED30016156) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Alpha-1-antiproteinase 2 (SMED30016156) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Alpha-1-antiproteinase 2 (SMED30016156) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30016156

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 20

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30016156h1SMcG0001402 Contig4154newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30016156h1SMcG0001402 Contig4154uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30016156h1SMcG0004573 Contig4154newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30016156h1SMcG0004573 Contig4154uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30016156h1SMcG0001402 Contig4154newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30016156h1SMcG0001402 Contig4154uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30016156h1SMcG0004573 Contig4154newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30016156h1SMcG0004573 Contig4154uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
parapharyngeal regionSMED30016156h1SMcG0001402 SmedASXL_015120SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30016156h1SMcG0001402 SmedASXL_015120SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
pharynxSMED30016156h1SMcG0001402 dd_Smed_v4_1853_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30016156h1SMcG0001402 dd_Smed_v4_1853_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30016156h1SMcG0001402 dd_Smed_v4_1853_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30016156h1SMcG0001402 dd_Smed_v4_1853_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynxSMED30016156h1SMcG0001402 dd_Smed_v4_1853_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30016156h1SMcG0001402 dd_Smed_v4_1853_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30016156h1SMcG0001402 dd_Smed_v4_1853_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30016156h1SMcG0001402 dd_Smed_v4_1853_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30016156h1SMcG0001402 OX_Smed_1.0.14122ox_Smed_v2PMID:24238224
Kao et al., 2013
whole organism asexual adult RNA-sequencing evidence
head regionSMED30016156h1SMcG0001402 OX_Smed_1.0.14122ox_Smed_v2PMID:24238224
Kao et al., 2013
whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Human
Match: SERPIND1 (serpin family D member 1 [Source:HGNC Symbol;Acc:HGNC:4838])

HSP 1 Score: 83.5741 bits (205), Expect = 1.143e-16
Identity = 64/255 (25.10%), Postives = 119/255 (46.67%), Query Frame = 2
Query:  479 DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            D A +   N  I KL+   +K  L   + P + + + + I+ K S+ N F  + T    F ++  + +K+ M+++ G  +   D+E+   I+   ++G   S+L+VVP K  G+  +E +LT         +M +    + +PK  L    ++  SLK MG+  +FD +  ++A I+    AID      +I +NE G          ++   +   GF  +  Q     + PFL +I+ H  + ++ + RV  P
Sbjct:  255 DPAFISKTNNHIMKLTKGLIKDALENID-PATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN-GNMAGISDQRIAIDLFKHQGTITVNEEG----------TQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Human
Match: SERPIND1 (serpin family D member 1 [Source:HGNC Symbol;Acc:HGNC:4838])

HSP 1 Score: 83.5741 bits (205), Expect = 1.143e-16
Identity = 64/255 (25.10%), Postives = 119/255 (46.67%), Query Frame = 2
Query:  479 DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            D A +   N  I KL+   +K  L   + P + + + + I+ K S+ N F  + T    F ++  + +K+ M+++ G  +   D+E+   I+   ++G   S+L+VVP K  G+  +E +LT         +M +    + +PK  L    ++  SLK MG+  +FD +  ++A I+    AID      +I +NE G          ++   +   GF  +  Q     + PFL +I+ H  + ++ + RV  P
Sbjct:  255 DPAFISKTNNHIMKLTKGLIKDALENID-PATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN-GNMAGISDQRIAIDLFKHQGTITVNEEG----------TQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Human
Match: SERPINI2 (serpin family I member 2 [Source:HGNC Symbol;Acc:HGNC:8945])

HSP 1 Score: 77.411 bits (189), Expect = 8.361e-15
Identity = 65/319 (20.38%), Postives = 141/319 (44.20%), Query Frame = 2
Query:  341 IICDLINHVTNGDKEFVEFKQENGIYVSSGVALENL----------DSLKHTKICKDDAGVKVLNEEIEKLSGHRLKS-FLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKS--GGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAA-IDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILSE 1255
            ++    + ++   +EF  F   N +Y+  G  ++             ++K        A  ++++  +E+ +  ++K  F   +  P + + L + I+ K  +   FR + T++  F      T+KIPM+K+       Y  +  +  +++  S+ G  FS+++++P +   + E+EK +TA++       M+     +++P+  +    D    L  + +T+IF G    L+ IT +    +  V+Q +   +NE G+             G+       + + Q  +AN PFL I+ ++   S++ + RV  P   E
Sbjct:   88 VLKSFFSAISEKKQEFT-FNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGG-CDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATST-------GIHIPVIMSLAQSQ-FIANHPFLFIMKHNPTESILFMGRVTNPDTQE 396          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Human
Match: SERPINI2 (serpin family I member 2 [Source:HGNC Symbol;Acc:HGNC:8945])

HSP 1 Score: 77.411 bits (189), Expect = 8.361e-15
Identity = 65/319 (20.38%), Postives = 141/319 (44.20%), Query Frame = 2
Query:  341 IICDLINHVTNGDKEFVEFKQENGIYVSSGVALENL----------DSLKHTKICKDDAGVKVLNEEIEKLSGHRLKS-FLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKS--GGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAA-IDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILSE 1255
            ++    + ++   +EF  F   N +Y+  G  ++             ++K        A  ++++  +E+ +  ++K  F   +  P + + L + I+ K  +   FR + T++  F      T+KIPM+K+       Y  +  +  +++  S+ G  FS+++++P +   + E+EK +TA++       M+     +++P+  +    D    L  + +T+IF G    L+ IT +    +  V+Q +   +NE G+             G+       + + Q  +AN PFL I+ ++   S++ + RV  P   E
Sbjct:   88 VLKSFFSAISEKKQEFT-FNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGG-CDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATST-------GIHIPVIMSLAQSQ-FIANHPFLFIMKHNPTESILFMGRVTNPDTQE 396          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Human
Match: SERPINI2 (serpin family I member 2 [Source:HGNC Symbol;Acc:HGNC:8945])

HSP 1 Score: 77.411 bits (189), Expect = 8.361e-15
Identity = 65/319 (20.38%), Postives = 141/319 (44.20%), Query Frame = 2
Query:  341 IICDLINHVTNGDKEFVEFKQENGIYVSSGVALENL----------DSLKHTKICKDDAGVKVLNEEIEKLSGHRLKS-FLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKS--GGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAA-IDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILSE 1255
            ++    + ++   +EF  F   N +Y+  G  ++             ++K        A  ++++  +E+ +  ++K  F   +  P + + L + I+ K  +   FR + T++  F      T+KIPM+K+       Y  +  +  +++  S+ G  FS+++++P +   + E+EK +TA++       M+     +++P+  +    D    L  + +T+IF G    L+ IT +    +  V+Q +   +NE G+             G+       + + Q  +AN PFL I+ ++   S++ + RV  P   E
Sbjct:   88 VLKSFFSAISEKKQEFT-FNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGG-CDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATST-------GIHIPVIMSLAQSQ-FIANHPFLFIMKHNPTESILFMGRVTNPDTQE 396          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Celegans
Match: srp-2 (SeRPin [Source:UniProtKB/TrEMBL;Acc:O17365])

HSP 1 Score: 61.6178 bits (148), Expect = 3.731e-10
Identity = 60/266 (22.56%), Postives = 120/266 (45.11%), Query Frame = 2
Query:  413 IYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKS-GGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGIS---INLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHY 1198
            +Y +SG   E+LD        + +   K +N  +E  +  ++K  +   +   +   L + ++ KA + + F  +ST   EF  S +++ +IP L        Y ED  +  +++   +    F++ + +P ++FGL +  +K+  E   +L  +++S   S+ IPK  +    D+  +L+ +G+ +IF    A L+ I         +S GI    I ++E G +       + ++  M       M E    VA+ PFL  + +
Sbjct:  105 LYKASG---ESLD------FSQTEQAAKTMNTFVENHTNGKIKDLIPADSANNAFAFLVNAMYFKADWQSKFAKESTTGREFFTSEAESRQIPFLTELDEHRDYTED--VLFQVLSLKYADPKFTLAIFLPKQRFGLVDALEKINGEYIQNLLNDLKSSYVSVQIPKFKIEKELDLKETLEAIGIKEIF-AEGADLSGIADKV----FISSGIHKAIIEVDEDGTTAAAASAFKVQLEMMI------MAEPTQFVADHPFLFAVLF 348          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Celegans
Match: srp-2 (SeRPin [Source:UniProtKB/TrEMBL;Acc:O17365])

HSP 1 Score: 61.6178 bits (148), Expect = 3.731e-10
Identity = 60/266 (22.56%), Postives = 120/266 (45.11%), Query Frame = 2
Query:  413 IYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKS-GGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGIS---INLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHY 1198
            +Y +SG   E+LD        + +   K +N  +E  +  ++K  +   +   +   L + ++ KA + + F  +ST   EF  S +++ +IP L        Y ED  +  +++   +    F++ + +P ++FGL +  +K+  E   +L  +++S   S+ IPK  +    D+  +L+ +G+ +IF    A L+ I         +S GI    I ++E G +       + ++  M       M E    VA+ PFL  + +
Sbjct:  105 LYKASG---ESLD------FSQTEQAAKTMNTFVENHTNGKIKDLIPADSANNAFAFLVNAMYFKADWQSKFAKESTTGREFFTSEAESRQIPFLTELDEHRDYTED--VLFQVLSLKYADPKFTLAIFLPKQRFGLVDALEKINGEYIQNLLNDLKSSYVSVQIPKFKIEKELDLKETLEAIGIKEIF-AEGADLSGIADKV----FISSGIHKAIIEVDEDGTTAAAASAFKVQLEMMI------MAEPTQFVADHPFLFAVLF 348          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Celegans
Match: srp-8 (SeRPin [Source:UniProtKB/TrEMBL;Acc:Q19651])

HSP 1 Score: 59.3066 bits (142), Expect = 2.294e-9
Identity = 87/373 (23.32%), Postives = 154/373 (41.29%), Query Frame = 2
Query:  152 ELAFGLLKESDQGKEVCISPXXXXXXXXXXXHSTSSEKVIAQIDKLLHLNXXXXXXXXXXXXXIICDLINHVTNGDKEFVEFKQE------NGIYVSSGVALENL--DSLKHTKICK--------DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLF-SYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPML-KSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGAS------VPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHY 1198
            E A  LL + D  +    SP+ I   L  L  +   E   +QI   L  N T+             +++ H +N        K++      N I   +G+  E+L  D +K    C+        +   +K +N+ I + +   +K      +  K  V +F S    +A + N F   ST   EF  +A+    I  L  +G    Y E+ +   +++   +   +F + + +P ++FGLAE  K L       L  N+ + L ++ IP        D++++L+ +G+T I + S A++    +     + + + I I +NE G S      V  +  +E            E  E +D +A+ PFL  IHY
Sbjct:   17 EFALKLLHQQDHSQSFVFSPIAISLALYSLYEAARGE-TRSQIHDCLFKNATDG------------EMVTHFSNVSTALSAMKKDPQVKICNHIICRNGIKTESLCLDKVKLLYNCEVSSHDLDNEKETIKTINKLIRENTDGHIKKINTKISIDKDQVVVFLSAACFEAQWQNKFHKLSTSKKEFFCTANSHRNIKFLHATGANRKYCENDKF--QVLSLPYTDSSFEMTIFLPKEQFGLAEALKTLGTSTIQELKSNVSNYLVNVQIPIWRNETEIDLNSTLQAIGITKILNES-AYIGNFAENVHISEFIHKAI-IEVNENGTSPATNTKVITKRWRE------------ETGEIRDFIADHPFLYTIHY 360          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Celegans
Match: srp-1 (SeRPin; Serine or cysteine protease inhibitor [Source:UniProtKB/TrEMBL;Acc:G5EE40])

HSP 1 Score: 56.225 bits (134), Expect = 1.924e-8
Identity = 38/167 (22.75%), Postives = 75/167 (44.91%), Query Frame = 2
Query:  476 KDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIF 976
            K     K++N+ I + +  ++   + P N       L + I  +  +   F   +     F +SA++   +PML+      YN+D E   +++   F   +    + +P ++F LAE  K L A K+ +L  N+      L  PK  ++   ++  +L K G+ ++F
Sbjct:  127 KSQEAAKIMNQFISESTKGKIPDMIKPDNLKDVDAILINAIFFQGDWRRKFGEPAE--SNFSISATENRLVPMLRETRDYFYNKDDEW--QVIGIPFKDKSAWFAIFLPTRRFALAENLKSLNAAKFHNLINNVYQEYIFLTFPKFKMDYKINLKTALAKFGLAELF 289          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Celegans
Match: srp-7 (SeRPin; Serine or cysteine protease inhibitor [Source:UniProtKB/TrEMBL;Acc:Q6QUQ6])

HSP 1 Score: 55.8398 bits (133), Expect = 3.128e-8
Identity = 48/200 (24.00%), Postives = 87/200 (43.50%), Query Frame = 2
Query:  596 IHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLM-YNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLII 1192
            ++ KA + N F+ DST   EF  SA    +I  L +  +   Y E+ +   +++   +    F++ + +P  +FGL E  K L +    HL  N+ S   ++ IPK  +     +  +L+ +G+   FD   A L  +      +  V+    I ++E G    K     +    +    F  M E +D  A+ PF  ++
Sbjct:  169 LYFKADWQNKFKKDSTFKSEFFSSADSKREIDFLHASSVSRDYAENDQF--QVLSLPYKDNTFALTIFLPKTRFGLTESLKTLDSATIQHLLSNVSSTSVNVQIPKWKIETKLGLEEALQSLGIKKAFDND-ADLGNMADG-LYVSKVTHKALIEVDEEGT---KAAAATTVSISLKSAMFV-MEEPKDFTADHPFFFVL 360          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Fly
Match: Spn47C (gene:FBgn0033574 transcript:FBtr0300862)

HSP 1 Score: 92.0485 bits (227), Expect = 4.980e-20
Identity = 63/254 (24.80%), Postives = 124/254 (48.82%), Query Frame = 2
Query:  488 GVKVLNEEIEKLSGHRLKSFLNPQ-NKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGN--MRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKI--TKAPAAIDHVSQGISINLNEFGASV-PKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIH-----YHVGNSV 1216
             VK +N+ +EK + + +++   P+     S V L + +  +A +  IF    T+I +F ++  + +++ M++  G   Y E K++ ++I+   F   N ++++++P    GL E+E+KL     + +     M+ V   + IPK  +    D+   L+KMG+  +FD   A L+ +   K P  I      + +N+ EFG  V P+ E++   +         + P+++   A+ PF+  I      Y VG+ V
Sbjct:  137 SVKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQLTQIDDFWINPRQRMEVSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAIDGLPELEEKLGQLDMNEVAAKSLMKEV--DVTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLSDLFEMKTPQKISEARHKVFLNVTEFGCEVAPEAEVQPEVL--------KKNPDRKFFKADRPFVFAIRDRKNVYFVGHFV 380          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Fly
Match: Spn47C (gene:FBgn0033574 transcript:FBtr0088211)

HSP 1 Score: 92.0485 bits (227), Expect = 4.980e-20
Identity = 63/254 (24.80%), Postives = 124/254 (48.82%), Query Frame = 2
Query:  488 GVKVLNEEIEKLSGHRLKSFLNPQ-NKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGN--MRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKI--TKAPAAIDHVSQGISINLNEFGASV-PKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIH-----YHVGNSV 1216
             VK +N+ +EK + + +++   P+     S V L + +  +A +  IF    T+I +F ++  + +++ M++  G   Y E K++ ++I+   F   N ++++++P    GL E+E+KL     + +     M+ V   + IPK  +    D+   L+KMG+  +FD   A L+ +   K P  I      + +N+ EFG  V P+ E++   +         + P+++   A+ PF+  I      Y VG+ V
Sbjct:  137 SVKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQLTQIDDFWINPRQRMEVSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAIDGLPELEEKLGQLDMNEVAAKSLMKEV--DVTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLSDLFEMKTPQKISEARHKVFLNVTEFGCEVAPEAEVQPEVL--------KKNPDRKFFKADRPFVFAIRDRKNVYFVGHFV 380          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Fly
Match: Spn47C (gene:FBgn0033574 transcript:FBtr0345584)

HSP 1 Score: 92.0485 bits (227), Expect = 4.980e-20
Identity = 63/254 (24.80%), Postives = 124/254 (48.82%), Query Frame = 2
Query:  488 GVKVLNEEIEKLSGHRLKSFLNPQ-NKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGN--MRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKI--TKAPAAIDHVSQGISINLNEFGASV-PKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIH-----YHVGNSV 1216
             VK +N+ +EK + + +++   P+     S V L + +  +A +  IF    T+I +F ++  + +++ M++  G   Y E K++ ++I+   F   N ++++++P    GL E+E+KL     + +     M+ V   + IPK  +    D+   L+KMG+  +FD   A L+ +   K P  I      + +N+ EFG  V P+ E++   +         + P+++   A+ PF+  I      Y VG+ V
Sbjct:  137 SVKKVNKWLEKHTFYTVRNLFTPEVFNSDSSVILVNSLFFRAKWNKIFPQQLTQIDDFWINPRQRMEVSMMRQIGQFRYGESKKLKSQILQLPFERSNLTMMIILPTAIDGLPELEEKLGQLDMNEVAAKSLMKEV--DVTIPKFRIECTVDLKVPLQKMGINSVFDAGQADLSDLFEMKTPQKISEARHKVFLNVTEFGCEVAPEAEVQPEVL--------KKNPDRKFFKADRPFVFAIRDRKNVYFVGHFV 380          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Fly
Match: Spn43Aa (gene:FBgn0024294 transcript:FBtr0089041)

HSP 1 Score: 77.0258 bits (188), Expect = 4.832e-15
Identity = 58/259 (22.39%), Postives = 118/259 (45.56%), Query Frame = 2
Query:  431 VALENLDS-LKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAP--AAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMP-EQQDIVANEPFLLIIH 1195
            VA +  DS ++     ++   V+ +N  +++ + ++++  +    +P + V L + I+ KA +   F  + T   EF +S S++I++P + +     Y +  E+ A+ +   F   N ++  ++P ++ GL  +E+KL    ++ L    +    S+ +PK      TD+  +L KMG++ +F  +         +P    I  V     I++NE G         E+       G    +P + +  VA+ PF  II 
Sbjct:  127 VAQKYFDSEVEPLDFSRETEAVEQINRWVKQQTENKIERVVESL-EPDTNVALVNAIYFKARWARPFNDEDTRDREFWLSESRSIQVPTMFADNWYYYADYPELDAKAIELFFENINLTMWFILPNQRSGLQALEQKLKGVDFNLLEDRWQWQSVSVYLPKFKFEFDTDLRPTLHKMGISAMFSDAADFSNIFQDSPIGTRITKVQHKTFIDVNEIGC--------EAAGASYAAGVPMSLPLDPKTFVADHPFAFIIR 376          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Fly
Match: Spn42Da (gene:FBgn0265137 transcript:FBtr0086204)

HSP 1 Score: 70.0922 bits (170), Expect = 8.543e-13
Identity = 62/282 (21.99%), Postives = 119/282 (42.20%), Query Frame = 2
Query:  407 NGIYVSSGVALEN----------LDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQN--KPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAP-----AAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYH 1201
            N I+V  G  L            L + +     K+      +N  +E+ + H +K  L P +    +S + L + IH K ++ + F    T    FH+   +T+++PM+       Y +   + A  +   +   + S+L+V+P  K GL  +E+KL     S +T ++     +L +P+       ++S   +K+G++ +F    A   K+ ++P     +AI H +    I +NE G       +       M    F+    ++  +AN PF   +  H
Sbjct:   94 NKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKD-LVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQ-AEFGKMLQSPEPLKVSAIIHKA---FIEVNEEGTEAAAATVWRV----MAVAAFS----RKHFIANHPFAFYVKTH 362          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Zebrafish
Match: serpind1 (serpin peptidase inhibitor, clade D (heparin cofactor), member 1 [Source:ZFIN;Acc:ZDB-GENE-030711-2])

HSP 1 Score: 92.8189 bits (229), Expect = 7.060e-20
Identity = 66/255 (25.88%), Postives = 119/255 (46.67%), Query Frame = 2
Query:  479 DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            D A +   N+ I+K++   +K  L   + P   V L +Y++ K ++   F  + T   +F V+  K +++ M+++ G  +   D E+   I+   + G N S+L+ VP K  G+  +E++++    +    NM +    +  P+  L    D+   LK+MG+TDIF       + +T     I+      SI +NE G          +E   M   GF  +  Q   + + PFL +I+ H    VV + RV++P
Sbjct:  263 DPAFLVKANQRIQKITKGLIKEPLKSVD-PNMAVMLLNYLYFKGTWEQKFPKELTHHRQFRVNEKKQVRVLMMQNKGSYLAAADHELNCDILQLPYAG-NISMLIAVPQKLSGMRSLEQEISPTLVNKWLSNMTNRTREVVFPRFKLEQNYDLIEHLKEMGMTDIFTEK-GDFSPMTSEKVIINWFKHQGSITVNEEG----------TEAAAMTHIGFMPLSTQTRFIVDRPFLFLIYEHRTGCVVFMGRVVDP 504          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Zebrafish
Match: serpind1 (serpin peptidase inhibitor, clade D (heparin cofactor), member 1 [Source:ZFIN;Acc:ZDB-GENE-030711-2])

HSP 1 Score: 92.8189 bits (229), Expect = 7.060e-20
Identity = 66/255 (25.88%), Postives = 119/255 (46.67%), Query Frame = 2
Query:  479 DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            D A +   N+ I+K++   +K  L   + P   V L +Y++ K ++   F  + T   +F V+  K +++ M+++ G  +   D E+   I+   + G N S+L+ VP K  G+  +E++++    +    NM +    +  P+  L    D+   LK+MG+TDIF       + +T     I+      SI +NE G          +E   M   GF  +  Q   + + PFL +I+ H    VV + RV++P
Sbjct:  263 DPAFLVKANQRIQKITKGLIKEPLKSVD-PNMAVMLLNYLYFKGTWEQKFPKELTHHRQFRVNEKKQVRVLMMQNKGSYLAAADHELNCDILQLPYAG-NISMLIAVPQKLSGMRSLEQEISPTLVNKWLSNMTNRTREVVFPRFKLEQNYDLIEHLKEMGMTDIFTEK-GDFSPMTSEKVIINWFKHQGSITVNEEG----------TEAAAMTHIGFMPLSTQTRFIVDRPFLFLIYEHRTGCVVFMGRVVDP 504          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Zebrafish
Match: si:ch1073-416d2.3 (si:ch1073-416d2.3 [Source:ZFIN;Acc:ZDB-GENE-131127-199])

HSP 1 Score: 71.633 bits (174), Expect = 5.449e-13
Identity = 54/253 (21.34%), Postives = 114/253 (45.06%), Query Frame = 2
Query:  497 VLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITK-APAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILS 1252
            ++NE + + +G ++   L    +P + + L + I  K  +   F P++TE   F+V     +++PM+         ED+++ AR++   + G   S+L+++P        +E +++AE+      NMR +   + +P+  ++    +   L ++G++ +F  S A L  +++ A   +  V     I + E G S                 G T        + N PF   +++    S++ + RV++P LS
Sbjct:  198 LINEFVSRKTGRKVLEMLE-SVEPLTQMLLLNTIFYKGDWERPFNPNNTEKSRFYVDKYNIVQVPMMMLEEKFSVVEDRDLRARVLRLPYRG-GASMLILLPSADADYTAIEDEISAERLHGWIKNMRRMKMEVHLPRFRMDQSYHMHELLPQLGISSVFQDS-ADLTGLSRDAHLKVSQVLHKAVIEVYEQGTSAA----------SSTSVGITAYSLPDTFIINRPFFFFLYHEETASLLFMGRVIDPTLS 437          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Zebrafish
Match: serpine1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [Source:ZFIN;Acc:ZDB-GENE-070912-60])

HSP 1 Score: 68.9366 bits (167), Expect = 2.946e-12
Identity = 49/221 (22.17%), Postives = 101/221 (45.70%), Query Frame = 2
Query:  596 IHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNE---DKEIGARIMYHSFLGCNFSVLVVVPIKK-FGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKI-TKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            +H    +   F P +T    FH      + +PM+ +     Y E      +   ++   + G + S+L+V P +K   L+ + K+L++ +       MR +   L+IP+ +++   D+ ++L +MG+ DIF  S A  ++I T+ P  +  V Q + + +NE G        K S         ++ M   ++I  + PF  +I +    +++   ++ +P
Sbjct:  179 LHFHGVWKTPFDPRNTREQLFHTVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDVIEMPYEGESISMLLVTPFEKDVPLSALNKELSSSRIHQWRQEMRKISKQLSIPRFSMDTEIDLKSTLSRMGLGDIFSQSRADFSRITTEEPLCVSKVLQRVKLEVNEEGT-------KGSSATAAVI--YSRM-AVEEITLDRPFFFLIQHKPTGALLFSGQLTQP 389          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Zebrafish
Match: serpina10a (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a [Source:ZFIN;Acc:ZDB-GENE-041014-246])

HSP 1 Score: 68.9366 bits (167), Expect = 3.095e-12
Identity = 50/251 (19.92%), Postives = 111/251 (44.22%), Query Frame = 2
Query:  500 LNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGC--NFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPA-AIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            +N+ +   +G +++  +   + P+S   L S       +   F    T+   F+V+    +++PM+   G      D      I+    L C    ++LV++P +      +++ +T E +      ++     + +P+ +L     +S SL  +GV +IF GS A+L  I+ +    +  V Q ++++++E G S+ +             G     P    +  N PF+ ++++ V   ++ + RV++P
Sbjct:  154 INDYVRGRTGEKVRDVVENVD-PQSMAILISAAFFTGQWLQPFNATFTQEDRFYVNKYNIVQVPMMLRSGKYYLAYDPTFKVGILK---LPCENGIAMLVLLPDEDVDYTYVDESMTGEVFRGWVAKLKKTKLEIQLPRFSLKQSNSLSVSLPSLGVKEIF-GSTANLTGISSSEGLKLSEVVQKVAVDVDESGGSLAE-----------ASGNLFMNPLPPRLTFNRPFIFVVYHEVTKCILYIGRVVDP 388          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Xenopus
Match: serpind1 (serpin peptidase inhibitor, clade D (heparin cofactor), member 1 [Source:NCBI gene;Acc:548433])

HSP 1 Score: 83.1889 bits (204), Expect = 1.592e-16
Identity = 64/251 (25.50%), Postives = 120/251 (47.81%), Query Frame = 2
Query:  503 NEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFD-GSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILS 1252
            N+ I++L+   +K  L   + P   + L + I+ K ++ N F  + T+   F ++  + +K+PM+K+ G  +   D E+   ++   ++G N S+L+V+P K  G+  +EK+++ +        M +    + +P+  L    ++   L  MGVTD+F  G  + ++          H  QG +I +NE G          +E   +   GF  +  Q   VA+ PFL +I+ H  N ++ + RV  P  S
Sbjct:  249 NKRIQQLTKGLIKEALTNVD-PALLMLLVNCIYFKGTWENKFPVEYTQNMNFRLNEKELVKVPMMKTKGNFLVAADPELDCAVLQLPYVG-NISMLIVLPHKLSGMKLLEKQISPQVVERWQNIMTNRTREVFLPRFKLEKSYNLQEVLSNMGVTDLFTHGDFSGVSDKNMNIGLFQH--QG-TITVNEEG----------TEAAAVTVVGFMPLSTQARFVADRPFLFLIYEHRTNCLIFMGRVANPTKS 484          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Xenopus
Match: marveld3 (MARVEL domain containing 3 [Source:Xenbase;Acc:XB-GENE-5929351])

HSP 1 Score: 76.6406 bits (187), Expect = 1.590e-14
Identity = 70/311 (22.51%), Postives = 138/311 (44.37%), Query Frame = 2
Query:  353 LINHVTNGDKEFVEFKQENGIYVSSGVALE------NLD----SLKHTKICKDDAGVKVLNEEIEKLS-GHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPM--LKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAP-AAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            L+  ++  +KEF  F   N +Y+  G  ++      N D    ++K        A  + ++E +++ + G   K F +    P + + L + ++ K  +   F  ++T   EF V    T+K+PM  L++   L Y   K    +++   + G  FS+L+ +P +   + E+EK +TA        +M+  +  +++P+  + +  D+  S   + +TDIF+     L+ IT++P   I  V Q + + +NE G+        +     M    F          AN PFL  I +     ++ + +V+ P
Sbjct:   98 LLAVISEENKEFT-FNLANALYLQEGFQVKEQYLHSNRDVFNSAIKLVDFQDVKASAETISEWVQRQTHGKISKMFSSGDFTPLTKMVLVNALYFKGEWKQKFSVEATHSEEFSVKRGLTVKVPMMHLQTTTKLGYFSVKNASYKVLELPYKGDKFSLLLTLPAEDVEIGELEKIVTATMIKTWFADMKEEVVEISLPRFKVEHKIDLKKSFLNLNITDIFNEG-CDLSGITESPNLYISKVFQKVFLEINEEGSEAAASTGMQVSAMSMSSHRFA---------ANRPFLFFIRHIQSGMILFMGKVMNP 397          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Xenopus
Match: SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 [Source:NCBI gene;Acc:100487295])

HSP 1 Score: 71.2478 bits (173), Expect = 7.809e-13
Identity = 59/252 (23.41%), Postives = 108/252 (42.86%), Query Frame = 2
Query:  500 LNEEIEKLSG---HRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAP-AAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            +N  +EKL+         F++PQ K    + L  YI  K  +   F P  TE+  F +    ++ +PM+     +    DK++   +    + G N  +L++ P K+     +E  LT E  +     M+S    +  PK  L+    + +SL ++G+ ++F G  A+L  +T+     +  ++Q   I ++E G         E   Y +             I  N PFL +I      S++ + RV++P
Sbjct:  170 INAYVEKLTKGLISNFYDFIDPQTK----LLLLDYIFFKGKWQYPFNPALTEVDSFFIDKYNSVTVPMMYKTDKVASVFDKDLSCTVFKLPYRG-NAHMLIIKPEKEGDFGILEDHLTKELINSWQAKMQSRKTDIFFPKFKLDQKYKLKSSLNELGIKELFTGK-ANLTDLTEERNLMLTEITQQAMIEVDERGTEAAAVAGAEIIAYSLPLT----------IRVNRPFLFMIFEEAYQSLLFLGRVMDP 405          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Xenopus
Match: SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) [Source:NCBI gene;Acc:100490491])

HSP 1 Score: 66.6254 bits (161), Expect = 2.479e-11
Identity = 70/321 (21.81%), Postives = 138/321 (42.99%), Query Frame = 2
Query:  344 ICDLINHVTNGDKEFVEFKQENGIYVSSGVALENLDSLK---------HTKICKDD--AGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKA----------PAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            + +L+N V+N     V +K  N +Y  S ++  + D +K         H+KI   D  + ++ +NE   + +  +L    +   +   G  + + +  K  +   F     +   F V+ S T+ +PM+   G+  Y ED++ G +I+         S+L ++P     L  +EK LT E+     G M     ++++PK++L    D+   L  +G+T+  D + A L+KI+             AA++  + G     N F + +  RE               E+   +    + PF+ +I     +S++ + R++ P
Sbjct:   96 LAELLNEVSNSTARNVTWKIGNRLYGPSSISFTD-DFVKNSKKHYNYEHSKINFRDKRSTLRSINEWASQATDGKLPEVTSDMER-TDGALIVNAMFFKPHWDERFHHQMVDNRGFMVTRSFTVSVPMMHRTGLYNYLEDEKNGLQILEMPLAHKLSSMLFIMPHHVEPLERVEKLLTREQVKTWVGKMTKKAVAVSLPKVSLEVSHDLQKHLGDLGLTEAIDKTKADLSKISGKKDLYLASMFHAAALEWDTDG-----NPFDSDIYSRE---------------ELRAPKLFYVDHPFVFLIKDEKTDSILFIGRLVRP 394          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Xenopus
Match: ENSXETT00000048100.1 (serine (or cysteine) proteinase inhibitor, clade A, member 3K [Source:NCBI gene;Acc:496632])

HSP 1 Score: 66.6254 bits (161), Expect = 2.817e-11
Identity = 53/225 (23.56%), Postives = 105/225 (46.67%), Query Frame = 2
Query:  569 KSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            K+ + L +YI+    +   F  + T+ G FHV  +  + +PM+   GM     D+++G  ++   + G N + L ++P  +  L ++E+ L  EK+S    +  ++   L +PKL+++  TD+   L K+GVTD+F  +      +   P  +      + ++++E G          +E  G+             I  N PF+L+I+     + + + RV+ P
Sbjct:  189 KTILVLINYIYFYGEWEKHFEKEWTKDGIFHVDENTNVTVPMMHRNGMYNVAFDEKLGCTVVQIPYKG-NATALFILP-DEGKLRQVEEAL--EKFSDAISD--NLFVHLTLPKLSISATTDLVKELSKLGVTDVFSDNSDLSGIVDVTPLKVSKAVHKVLVSIDETG----------TEAAGVTVMEIVPTMLPPRIEYNRPFVLMIYEPTLRANLFMGRVMNP 397          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Mouse
Match: Serpind1 (serine (or cysteine) peptidase inhibitor, clade D, member 1 [Source:MGI Symbol;Acc:MGI:96051])

HSP 1 Score: 80.4925 bits (197), Expect = 7.966e-16
Identity = 59/255 (23.14%), Postives = 120/255 (47.06%), Query Frame = 2
Query:  479 DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            D A +   N  I KL+   +K  L   + P + + + + I+ K ++ N F  + T    F ++  + +K+ M+++ G  +   D+E+   I+   ++G   S+L+VVP K  G+  +E +LT +       +M +    + +PK  L    ++   LK MG+T +F+ +  +++ I+    AID      +I +NE G          ++   +   GF  +  Q     + PFL +++ H  + ++ + +V  P
Sbjct:  234 DPAFISKANNHILKLTKGLIKEALENID-PATQMLILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKN-GNMSGISDQRIAIDLFKHQSTITVNEEG----------TQAAAVTTVGFMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVTNP 475          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Mouse
Match: Serpind1 (serine (or cysteine) peptidase inhibitor, clade D, member 1 [Source:MGI Symbol;Acc:MGI:96051])

HSP 1 Score: 80.4925 bits (197), Expect = 7.966e-16
Identity = 59/255 (23.14%), Postives = 120/255 (47.06%), Query Frame = 2
Query:  479 DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            D A +   N  I KL+   +K  L   + P + + + + I+ K ++ N F  + T    F ++  + +K+ M+++ G  +   D+E+   I+   ++G   S+L+VVP K  G+  +E +LT +       +M +    + +PK  L    ++   LK MG+T +F+ +  +++ I+    AID      +I +NE G          ++   +   GF  +  Q     + PFL +++ H  + ++ + +V  P
Sbjct:  234 DPAFISKANNHILKLTKGLIKEALENID-PATQMLILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKN-GNMSGISDQRIAIDLFKHQSTITVNEEG----------TQAAAVTTVGFMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVTNP 475          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Mouse
Match: Serpina1e (serine (or cysteine) peptidase inhibitor, clade A, member 1E [Source:MGI Symbol;Acc:MGI:891967])

HSP 1 Score: 80.1073 bits (196), Expect = 9.408e-16
Identity = 61/222 (27.48%), Postives = 105/222 (47.30%), Query Frame = 2
Query:  584 LFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITK--APAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            L +YI  K  +   F P++T+  EFHV  S T+K+PM+   GML  +    + + ++   + G   +V ++    K  +  +E+ L  E  S    N R  L  + IP+L+++   ++   +  +G+T IF+ S A L+ IT+  AP  +        + ++E G         E+    +  GGF  MP    +  N PFL II      S + V +V++P
Sbjct:  202 LANYILFKGKWKKPFDPENTKQAEFHVDESTTVKVPMMTLSGMLDVHHCSTLSSWVLLMDYAGNATAVFLLPDDGK--MQHLEQTLNKELISKFLLNRRRRLAQIHIPRLSISGNYNLETLMSPLGITRIFN-SGADLSGITEENAPLKLSQAVHKAVLTIDETGT--------EAAAATVLQGGFLSMPPI--LHFNRPFLFIIFEEHSQSPLFVGKVVDP 410          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Mouse
Match: Serpina1e (serine (or cysteine) peptidase inhibitor, clade A, member 1E [Source:MGI Symbol;Acc:MGI:891967])

HSP 1 Score: 80.1073 bits (196), Expect = 9.408e-16
Identity = 61/222 (27.48%), Postives = 105/222 (47.30%), Query Frame = 2
Query:  584 LFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITK--APAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            L +YI  K  +   F P++T+  EFHV  S T+K+PM+   GML  +    + + ++   + G   +V ++    K  +  +E+ L  E  S    N R  L  + IP+L+++   ++   +  +G+T IF+ S A L+ IT+  AP  +        + ++E G         E+    +  GGF  MP    +  N PFL II      S + V +V++P
Sbjct:  202 LANYILFKGKWKKPFDPENTKQAEFHVDESTTVKVPMMTLSGMLDVHHCSTLSSWVLLMDYAGNATAVFLLPDDGK--MQHLEQTLNKELISKFLLNRRRRLAQIHIPRLSISGNYNLETLMSPLGITRIFN-SGADLSGITEENAPLKLSQAVHKAVLTIDETGT--------EAAAATVLQGGFLSMPPI--LHFNRPFLFIIFEEHSQSPLFVGKVVDP 410          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Mouse
Match: Serpinb9g (serine (or cysteine) peptidase inhibitor, clade B, member 9g [Source:MGI Symbol;Acc:MGI:1919260])

HSP 1 Score: 74.7146 bits (182), Expect = 4.560e-14
Identity = 51/228 (22.37%), Postives = 106/228 (46.49%), Query Frame = 2
Query:  569 KSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGN--MRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKI-TKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            ++ + L + ++   ++C  F  + T+   F ++  +T  + M+     L +   KEI A+++   + G + + +V++P +   ++++E  LT EK +  T    M      + +PK  L    D+++ L+ +G+ ++FDGS A L+ + TK    +   +    + +NE G          +  +   C G    P+ +   A+ PFL  I +   NS++   R   P
Sbjct:  157 QTRLILANALYFHGTWCKRFEKNRTKEMPFKINKKETRPVQMMWREDTLFHAYVKEIQAQVLVMPYEGIDLNFVVLLPDEGVDISKVENNLTFEKLTAWTKPEFMNRTEFHVYLPKFQLQEDYDMNSLLQHLGILNVFDGSKADLSGMSTKENLCLSEFAHKCVVEVNEEGTEAAA---ASAVKFIFLCSG----PDPETFCADHPFLFFIMHRTTNSILFCGRFSSP 377          
BLAST of Alpha-1-antiproteinase 2 vs. UniProt/SwissProt
Match: sp|Q5MGH0|SPI3_LONON (Serine protease inhibitor 3/4 (Fragment) OS=Lonomia obliqua OX=304329 PE=1 SV=1)

HSP 1 Score: 85.8853 bits (211), Expect = 5.760e-17
Identity = 58/232 (25.00%), Postives = 112/232 (48.28%), Query Frame = 2
Query:  389 VEFKQENGIYVSSGVALENL----------DSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQN-KPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEK-YSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGI 1048
            V  K  N IY+++G  L +             ++     ++    K +N  +E  + +R+K  ++P +    +   L + ++ K S+ N F  +ST    FHV  +KTI++P +   G   Y E +E+ A+I+   + G   S+++V+P    G+  + +KL   K  S +  +M  +   + +PK  +   TD+   L+ M +  +F+GS A L  + K   A+ +VS+ +
Sbjct:  109 VTLKIANKIYIANGFELNDQFAVVSKDVFNSEVQKLDFAQNKVAAKTINTWVEDHTNNRIKDLVDPNSLDDYTRAVLVNALYFKGSWKNKFDKESTIDRPFHVDNTKTIQVPTMHRSGQYSYGESRELNAKIIEMPYEGDETSLVIVLPNTVDGIHNLLEKLKDPKVLSRVEKDMHEIDVDVYVPKFKIETTTDLKKVLQNMNIKKLFNGSEARLDYLLKKSDAL-YVSEAV 339          
BLAST of Alpha-1-antiproteinase 2 vs. UniProt/SwissProt
Match: sp|P05546|HEP2_HUMAN (Heparin cofactor 2 OS=Homo sapiens OX=9606 GN=SERPIND1 PE=1 SV=3)

HSP 1 Score: 83.5741 bits (205), Expect = 5.491e-16
Identity = 64/255 (25.10%), Postives = 119/255 (46.67%), Query Frame = 2
Query:  479 DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            D A +   N  I KL+   +K  L   + P + + + + I+ K S+ N F  + T    F ++  + +K+ M+++ G  +   D+E+   I+   ++G   S+L+VVP K  G+  +E +LT         +M +    + +PK  L    ++  SLK MG+  +FD +  ++A I+    AID      +I +NE G          ++   +   GF  +  Q     + PFL +I+ H  + ++ + RV  P
Sbjct:  255 DPAFISKTNNHIMKLTKGLIKDALENID-PATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN-GNMAGISDQRIAIDLFKHQGTITVNEEG----------TQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496          
BLAST of Alpha-1-antiproteinase 2 vs. UniProt/SwissProt
Match: sp|P47776|HEP2_RABIT (Heparin cofactor 2 OS=Oryctolagus cuniculus OX=9986 GN=SERPIND1 PE=2 SV=1)

HSP 1 Score: 82.0333 bits (201), Expect = 2.048e-15
Identity = 58/258 (22.48%), Postives = 123/258 (47.67%), Query Frame = 2
Query:  479 DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILS 1252
            D A +   N  I K++   +K  L   + P + + + + I+ K ++ N F  + T    F ++  + +K+ M+++ G  +   D+E+   ++   ++G   S+L+VVP K  G+  +E +LT +       +M +    + +PK  L    ++  +LK MGVT++FD +  +++ I+     +D      +I +NE G          ++   +   GF  +  Q     + PFL +++ H  + ++ + +V  P+ S
Sbjct:  236 DPAFISKANNHILKVTKGLIKEALENVD-PATQMMILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELACDVLQLEYVG-GISMLIVVPHKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEALKSMGVTELFDKN-GNMSGISDQGITMDLFKHQGTITVNEEG----------TQAAAVTTVGFMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVANPVRS 480          
BLAST of Alpha-1-antiproteinase 2 vs. UniProt/SwissProt
Match: sp|P49182|HEP2_MOUSE (Heparin cofactor 2 OS=Mus musculus OX=10090 GN=Serpind1 PE=1 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 5.572e-15
Identity = 59/255 (23.14%), Postives = 120/255 (47.06%), Query Frame = 2
Query:  479 DDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            D A +   N  I KL+   +K  L   + P + + + + I+ K ++ N F  + T    F ++  + +K+ M+++ G  +   D+E+   I+   ++G   S+L+VVP K  G+  +E +LT +       +M +    + +PK  L    ++   LK MG+T +F+ +  +++ I+    AID      +I +NE G          ++   +   GF  +  Q     + PFL +++ H  + ++ + +V  P
Sbjct:  234 DPAFISKANNHILKLTKGLIKEALENID-PATQMLILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKN-GNMSGISDQRIAIDLFKHQSTITVNEEG----------TQAAAVTTVGFMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVTNP 475          
BLAST of Alpha-1-antiproteinase 2 vs. UniProt/SwissProt
Match: sp|Q00898|A1AT5_MOUSE (Alpha-1-antitrypsin 1-5 OS=Mus musculus OX=10090 GN=Serpina1e PE=1 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 6.581e-15
Identity = 61/222 (27.48%), Postives = 105/222 (47.30%), Query Frame = 2
Query:  584 LFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITK--APAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            L +YI  K  +   F P++T+  EFHV  S T+K+PM+   GML  +    + + ++   + G   +V ++    K  +  +E+ L  E  S    N R  L  + IP+L+++   ++   +  +G+T IF+ S A L+ IT+  AP  +        + ++E G         E+    +  GGF  MP    +  N PFL II      S + V +V++P
Sbjct:  202 LANYILFKGKWKKPFDPENTKQAEFHVDESTTVKVPMMTLSGMLDVHHCSTLSSWVLLMDYAGNATAVFLLPDDGK--MQHLEQTLNKELISKFLLNRRRRLAQIHIPRLSISGNYNLETLMSPLGITRIFN-SGADLSGITEENAPLKLSQAVHKAVLTIDETGT--------EAAAATVLQGGFLSMPPI--LHFNRPFLFIIFEEHSQSPLFVGKVVDP 410          
BLAST of Alpha-1-antiproteinase 2 vs. TrEMBL
Match: A0A3B3RAX4 (Serpin peptidase inhibitor, clade D (heparin cofactor), member 1 OS=Paramormyrops kingsleyae OX=1676925 PE=3 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 5.659e-21
Identity = 78/291 (26.80%), Postives = 134/291 (46.05%), Query Frame = 2
Query:  407 NGIYVSSGVALEN--LDSLK-------HTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNK---PKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            N +YV   + LE      +K        T   KD A + + N  I+KL+    K  +N   K   P   + L +YI+ K ++   F  D+T    FH+S  K +++PM+++ G      D E+   ++   ++G N S+LV +P K  G+  +EK+++         NM +    +  PK  L    D+  +LK+MGV D+F G     +K+T     I+      +I +NE G          ++   +   GF  +  Q   V + PFL +I+ H  N ++ + RV++P
Sbjct:  230 NDLYVKRDITLEEPFRKDMKTYYFAEPQTVDFKDPAFLGMANRRIQKLT----KGLINMPLKSVDPNMVMMLLNYIYFKGNWEQKFSKDATYYRNFHISERKYVRVPMMQNRGNYQAAADHELQCDVLQMPYIG-NISMLVALPRKISGMRNLEKEISPSVIKRWMSNMTNRTREVVFPKFTLEQNYDLIENLKEMGVKDLF-GETGDFSKMTSEKIMINWFKHQGTITVNEEG----------TQAASVTHVGFMPLSSQIRFVVDRPFLFLIYEHRTNCLLFIGRVVDP 504          
BLAST of Alpha-1-antiproteinase 2 vs. TrEMBL
Match: W5M2R7 (Serpin peptidase inhibitor, clade D (heparin cofactor), member 1 OS=Lepisosteus oculatus OX=7918 PE=3 SV=1)

HSP 1 Score: 102.064 bits (253), Expect = 1.750e-19
Identity = 67/256 (26.17%), Postives = 125/256 (48.83%), Query Frame = 2
Query:  476 KDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            +D A +   N+ I KL+   +K  L   N P + + L +Y++ K ++ N F    T    F +S  +T+++PM+++ G  +   D E+   I+  S++G N S+LV +P K  G+  +E +++    +    +M +    +  PK  L    ++   LK+MG+TD+F+   A  + +T    AID      +I +NE G          +E   +   GF  +  Q   + + PFL +I+ H  + ++ + RV+ P
Sbjct:  264 RDPAFLLKANQRISKLTKGLIKEGLKNVN-PDTVLMLLNYLYFKGTWENKFPAKQTSYRSFRLSERETVRVPMMQTKGNFLAAADHELDCDILQMSYVG-NISMLVAIPRKLSGMRNLETQISPAVVNRWINSMTNRTREVVFPKFKLERNYNLIGHLKEMGLTDLFN-VTADFSGMTDEKIAIDMFKHQATITVNEEG----------TEAAAVTTVGFMPLSAQIRFIVDRPFLFLIYEHRTSCLLFMGRVVNP 506          
BLAST of Alpha-1-antiproteinase 2 vs. TrEMBL
Match: B4MDT6 (SERPIN domain-containing protein OS=Drosophila virilis OX=7244 GN=Dvir\GJ18186 PE=3 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 9.362e-19
Identity = 63/255 (24.71%), Postives = 129/255 (50.59%), Query Frame = 2
Query:  482 DAGVKVLNEEIEKLSGHRLKSFLNPQN-KPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLG--SLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKI--TKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIH-----YHVGNSV 1216
            +  ++ +N+ +E+ + + ++  L P +   +S V L + ++ +A +   F  + T +G+F +S  + +++PM++  G   Y E +++ +RI+   F   + ++L+++P +  GLAE+E KL     + +   ++SV+    + +P+       D+   LKK+G+  IF+ S A L+ +   K+P  I    Q + +N+NE G  +      E+          T  PE++   A+ PF+  I      Y VG+ V
Sbjct:  137 EGAMRQVNKWLERQTFNTVRDLLTPASFNVESNVILVNSLYFRAKWTKQFSVERTSLGDFAISEEQKMQLPMMRQAGQFRYGESRKLKSRILQLPFDESDVNMLLILPDETMGLAELESKLGEIDLNEVA--LKSVMHDVDITVPRFKFECDIDLKVPLKKLGIKRIFEKSAADLSGLFAKKSPQLITEARQKLYLNVNEAGCEIDANTPAETSTE-------TSNPERKVFTADHPFVFAIRNFKSVYVVGHFV 382          
BLAST of Alpha-1-antiproteinase 2 vs. TrEMBL
Match: A0A401SAN7 (SERPIN domain-containing protein OS=Chiloscyllium punctatum OX=137246 GN=chiPu_0005895 PE=3 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 1.986e-18
Identity = 71/255 (27.84%), Postives = 127/255 (49.80%), Query Frame = 2
Query:  482 DAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKA-PAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            D   + +N  + K +  +++ F+   N+  + + L +YI  K  +   F P  T   +FHV  + T+K+ M+K  G    N D+E+ + ++   + G N S+++++P ++  LAE+E+ LT   + +L  + R     L +PKL+L     +   L  MG+ DIF  + A+L+KITK+ P  +  V     ++++E G          +E   +   G   M +   +  N PFLL+I  H   SV+   RV+ P
Sbjct:  245 DKAKRKINAYVRKQTNGKIQEFIKTLNR-NTVMVLINYILFKGKWVKPFDPQKTYEDDFHVDDTTTVKVQMMKRKGRYYMNYDEELRSSVILIPYRG-NASLVLILP-ERGKLAEVEQNLTITNFQNLITSSRIGSVDLRLPKLSLRLTYQLKQLLITMGLVDIFSNN-ANLSKITKSGPVHVSKVIHEAVLDVDERG----------TEATAVTGVGLMPMSKPPQLKFNRPFLLLIAEHSSKSVLFAGRVMNP 485          
BLAST of Alpha-1-antiproteinase 2 vs. TrEMBL
Match: A0A1B6I722 (SERPIN domain-containing protein OS=Homalodisca liturata OX=320908 GN=g.39406 PE=3 SV=1)

HSP 1 Score: 96.6709 bits (239), Expect = 4.721e-18
Identity = 75/275 (27.27%), Postives = 132/275 (48.00%), Query Frame = 2
Query:  440 ENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKP-KSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEM-------PEQQDIVANEPFLLIIHYHVGNSVVSVNRVLE 1240
            E++D +K T    ++A V + N  +E  +  ++ + L P      + + L + IH KA++   F+   T+   FHVS +K++ + M+       +  DK++GA+I+   + G +F +LV++P +  GLA++E+KL     S     M+    ++A+PK  +    D++  LK MGV  +F    A+ + I+  P  +  V Q   + +NE G                   GF  M       P  Q  +A+ PFL II +   N+ + V R+LE
Sbjct:  147 ESVDFMKDT----ENARVHI-NSWVEDQTNKKITNLLAPGILSCDTRLVLVNAIHFKANWSKQFQEKDTKEQPFHVSKTKSVPVQMMNIKKKFGFVHDKDLGAKILELEYEGGHFRMLVILPDEIDGLAKLEEKLEKVNLSDKIKYMQQPTVTVALPKFKMEETMDLNDILKSMGVETMFSQK-ANFSGISDVPLVVSKVVQKAFVEVNEKGTE------------AAAATGFIMMRNCARVEPTPQSFIADHPFLFIIMFK--NTTLFVGRMLE 401          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Cavefish
Match: serpind1 (serpin family D member 1 [Source:NCBI gene;Acc:103036946])

HSP 1 Score: 84.7297 bits (208), Expect = 3.280e-17
Identity = 58/247 (23.48%), Postives = 114/247 (46.15%), Query Frame = 2
Query:  503 NEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            N+ I+K++   +K  L   + P   V L +Y++ K ++   F  + T    F V+    +++ M+++ G  +   D E+   ++   + G N S+++ VP K  G+  +E++++    +    NM +    +  P+  L    D+   +KK+G+TD+F       + +T     I+      +I +NE G          +E   M   GF  +  Q   V + PFL +I+ H  + +V + RV +P
Sbjct:  278 NQRIQKITKGLIKEPLKSVD-PNMVVMLLNYLYFKGTWEQKFPKELTHFRNFRVNEKHQVRVAMMQNKGSYLAAADHELHCDVLQLPYKG-NISMMIAVPQKLSGMRTLEQEISPTVINKWLNNMTNRTREVVFPRFKLEQSYDLIRHMKKLGLTDLFTEK-GDFSPMTSEKVTINWFQHQGTITVNEEG----------TEAAAMTHIGFMPLSTQTRFVVDRPFLFLIYEHRTDCLVFMGRVSDP 511          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Cavefish
Match: si:ch1073-416d2.3 (protein Z-dependent protease inhibitor-like [Source:NCBI gene;Acc:103042318])

HSP 1 Score: 74.7146 bits (182), Expect = 3.358e-14
Identity = 55/269 (20.45%), Postives = 116/269 (43.12%), Query Frame = 2
Query:  437 LENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            +EN+D        K D   + +N+ + K +G ++K  ++   +P + + L + I  + ++   F P++TE   F++     +++PM+ S        D E+ A+++   +LG   ++L+V+P        ++ ++ AE++ +   N++     + IPK  L     +   L  MG+ ++F  S        ++   +  V     I ++E G                   G T          N PF   I++   NS++ + RV++P
Sbjct:  150 VENVD------FGKADISKETINKHVRKKTGDKVKEIVS-SIEPLTQMMLINTIFFQGAWERPFNPNNTEKSRFYIDKYNIVQVPMMFSTDKFYIASDDELKAKVLRLPYLGGA-AMLIVLPDSNVDYTIIDDEINAERFLNWIKNLKKTKLEVYIPKFKLEQSYSLHKILPSMGIQNVFTYSANLKGMSQESGIKVSQVLHKAVIEVDEKGTVAA----------AATTVGITAYSMPTTFTVNRPFFFFIYHEATNSLLFMGRVIDP 400          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Cavefish
Match: serpinc1 (serpin family C member 1 [Source:NCBI gene;Acc:103038850])

HSP 1 Score: 70.0922 bits (170), Expect = 1.382e-12
Identity = 53/231 (22.94%), Postives = 103/231 (44.59%), Query Frame = 2
Query:  578 VTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISIN---------LNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            + L + I+ K  + N F        +FHVS++K  ++ M+       Y +  E   +++   + G   S+++V+P+K   L E+EK +T  K ++ T  M     ++ IP+  + +   +   ++ MG+  +F    A L      P  ++ V  GI I+         +NE G+       + +    +   G +    ++  VAN+PFLL I     N+++   R+  P
Sbjct:  249 MVLVNTIYFKGQWKNKFDKKDVMSLQFHVSSTKKCQVHMMYKEAKFQYKKFPEDKVKVLELPYNGGGISMVLVLPMKDSNLTEVEKIITYSKLTNWTNTMSETTVAVQIPRFRIEDSFSLKEKMRDMGLNHLFSAEHASL------PGIVEGVDNGIYISDAYHKAFLEVNEEGS-------EAAAATAVVALGRSLNVNRESFVANKPFLLFIREATINTIIFAGRISNP 466          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Cavefish
Match: serpine1 (serpin family E member 1 [Source:NCBI gene;Acc:103042062])

HSP 1 Score: 69.3218 bits (168), Expect = 1.727e-12
Identity = 70/307 (22.80%), Postives = 136/307 (44.30%), Query Frame = 2
Query:  392 EFKQENGIYVSSGVALEN---------------LDSLKH-TKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQN--KPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNE--DKE-IGARIMYHSFLGCNFSVLVVVPIKK-FGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKI-TKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            +   E+G+ V+SGV ++                  S+ H     +     +V+N      +G  + +FL P      ++ + L + +H    +   F P  T    FH     T+ +PM+++     Y E   KE +   ++   + G + S+L+V   +K   L+ + K+L+  K      N++ V   L +P+ +++   D+ ++L K+G+ DIF  S A  ++I T+ P  +  V Q + I + E G        K S         ++ M  ++ I+ + PFL +I +    SV+ + +V +P
Sbjct:   94 DLSSEHGVEVASGVMVDRKLMLEKPFRRSLTKAFQSVPHQVDFSQPKTAQQVINAWTSDRTGGMIPNFL-PSGLLSQQTRLVLLNALHFHGLWMTPFDPSLTMEMMFHGPNGSTLPVPMMRTTNKFNYGEFVTKEGVDYDVIEVPYEGDSMSMLLVSSFEKDMPLSALIKELSGSKVQEWRKNIKKVNRQLVLPRFSIDTEVDLKSTLSKLGLGDIFSQSKADFSRITTEEPLCVSDVLQRVKIEVKEDGT-------KGSSATAAII--YSRMAVEEHIM-DRPFLFLIQHKPTGSVLFMGQVNQP 389          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Cavefish
Match: serpinh1b (serpin H1-like [Source:NCBI gene;Acc:103039097])

HSP 1 Score: 64.6994 bits (156), Expect = 7.292e-11
Identity = 66/310 (21.29%), Postives = 139/310 (44.84%), Query Frame = 2
Query:  344 ICDLINHVTNGDKEFVEFKQENGIYVSSGVAL--ENLDSLK------HTKICKDD--AGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            + +L++ V++     V +K  N +Y  S V+   E + S K      H+KI   D  + +  +NE   K +  +L   +    K   G  + + +  K  +   F     +   F V+ S T+ +PM+   G+  ++ED E    ++         SV+ ++P     L  +EK LT ++       M     ++++PK+++    D+   L ++G+T++ D S A L+ I+          + + ++ N F AS  + +  E   +     G  ++   +   A+ PF+ ++  +  NS++ + R+++P
Sbjct:  101 LSELLSEVSDPAARNVTWKINNRLYGPSSVSFADEFVKSSKKHYNYEHSKINFRDKRSAINSINEWAAKSTDGKLPE-ITKDVKNTDGAMIINAMFFKPHWDEKFHHKMVDNRAFLVTRSYTVSVPMMHRTGLYPFHEDTENRLFVLNMPLAHKKSSVIFIMPYHVEPLERLEKLLTRQQLDKWISKMEERAVAVSLPKVSMEVSHDLQKHLGELGLTEVVDKSKADLSNISG--------KKDLYLS-NVFHASAWEWD-TEGNPFDTSIFGSDKLRNPKLFYADHPFIFVVKDNQTNSILYIGRLVKP 399          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Sea Lamprey
Match: serpind1 (serpin peptidase inhibitor, clade D (heparin cofactor), member 1 [Source:ZFIN;Acc:ZDB-GENE-030711-2])

HSP 1 Score: 75.485 bits (184), Expect = 4.500e-15
Identity = 66/266 (24.81%), Postives = 125/266 (46.99%), Query Frame = 2
Query:  461 HTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIK-KFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAP----AAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            HT   KD A V+ +N  +   +   +   +   + P +   + + ++ K  +   F    T +  F ++  +T+K+ M+++    +   D E+G  I+  ++ G N S+++ VP K K GL  +E+ L+ +        M +    + IPK  L    ++  +LK++GVT++F  + A L+ +T A     ++  H  QG  I ++E G          SE   +   GFT +      VA+ PF+ I++ H   SV+ + +V  P
Sbjct:  193 HTVDFKDPATVQRINRWVSSATKGTISDAVTNID-PSTVFLVINSVYFKGPWEIKFSKHQTSVRSFRLNDKETVKVQMMQTKASFLVTTDHELGCDILQLAYQG-NVSMILAVPHKLKGGLKTLERALSFDLLEKWLQAMTNRTRDVIIPKFNLQQKYNLKNNLKELGVTELFQAN-ADLSGMTGAKDVQVSSFQH--QGF-IKIDEEG----------SEAAAVTTVGFTPLTSHNRFVADRPFVFIVYEHHTMSVLFLGQVSNP 442          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006795.1 (pep scaffold:Pmarinus_7.0:GL479006:3227:9631:1 gene:ENSPMAG00000006108.1 transcript:ENSPMAT00000006795.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 70.8626 bits (172), Expect = 1.581e-13
Identity = 62/259 (23.94%), Postives = 128/259 (49.42%), Query Frame = 2
Query:  488 GVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLG------SLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAA-IDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
             V+++N  IEK++  +    ++  +   S + + + I+ K S+ N F PD T+   F V++S ++ +P +     L Y +D+++ + ++   + G   S+LV+VP +   L ++E+ ++ E+         S+LG       L++PK  ++   D+ A L  MG+  +F    A L++IT      +D ++    +++NE G      E K   + G+       MP    +  + PF+++I+     +V+ + RV +P
Sbjct:  236 AVELMNAYIEKVTSKKFTDVISDVDTATS-LMIVNVIYFKGSWANKFEPDLTKNVRFWVNSSYSMMVPTMHQRAKLSYAQDRKLRSTVIKLPYEGGA-SMLVIVPHRTEELPKVEESVSQEQLEEWL----SLLGPSNHYVQLSLPKFKISVSYDLKAYLSAMGMPSMFSYG-ADLSRITGMQKLHVDKITHKSVLHVNEEGT-----EAKAETVVGIMP---ISMPPT--VTVDRPFVVLIYDEKTRAVIFMGRVADP 477          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Sea Lamprey
Match: serpinf1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 [Source:ZFIN;Acc:ZDB-GENE-040912-2])

HSP 1 Score: 62.7734 bits (151), Expect = 5.458e-11
Identity = 43/150 (28.67%), Postives = 81/150 (54.00%), Query Frame = 2
Query:  584 LFSYIHIKASFCNIFRPDSTEIGEFHVSASK----TIKIPMLKSGGM-LMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFG-LAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKA 1015
            L S +H+KA +   F P+ T  G FH    K     +++  ++   + + Y  D E+GA        GC  S+L+ VP++  G L  +E+ LT+E  + +   + SV   L++P+LAL +  D++ ++K++ +  +F  S A L+ +++A
Sbjct:  210 LVSAMHVKAKWALQFPPEETAQGVFHAGGGKRGPVALRVATMRRDDVPIRYGLDTELGAVAQLPLQGGC--SLLLFVPVEVTGNLTVVEESLTSEFVADIVRALHSVRARLSVPRLALRDAGDLAGAVKQLELESLFS-SDADLSALSEA 356          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Sea Lamprey
Match: serpinh1a (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a [Source:ZFIN;Acc:ZDB-GENE-080219-21])

HSP 1 Score: 46.9802 bits (110), Expect = 5.288e-6
Identity = 43/191 (22.51%), Postives = 79/191 (41.36%), Query Frame = 2
Query:  395 FKQENGIYVSSGVALEN--------LDSLKHTKI-CKDDAG-VKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDV 937
            +K  + +Y  SGV               L+H K+  KD  G +K LNE   + +G ++K      +    G    + +  K  +   F     +   F  S S TI I M+   G   +  D++   +++     G   S+L+ +P+    L  +EK LT ++    T  ++    ++++PK  L    D+
Sbjct:  147 WKAASRVYAPSGVTFSQGFVSSSKARYGLQHDKVNLKDKRGALKALNEWAAQNTGGKVKEVAKELDGA-DGAVFVNALFFKGRWNEKFHHQMVDTRGFLTSRSHTISIQMMHRTGFYNFYHDEKAQVQLLEMQLKGNLESLLIALPLHTESLERLEKLLTKQQLEEWTSKLQKKTIAVSMPKGLLQGSADI 336          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Nematostella
Match: EDO40288 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7S1])

HSP 1 Score: 77.7962 bits (190), Expect = 1.226e-15
Identity = 68/293 (23.21%), Postives = 135/293 (46.08%), Query Frame = 2
Query:  392 EFKQENGIYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQ---NKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGS---LAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCG---GFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            EFK+ +    S+ +AL  +D +K++   +D      +N  +E+ +  ++K+ + P+   NK  + + L + ++ K S+   F  ++T+ G+F  + S+ I++  +       Y E   +G +I+   + G   S++V++P +  GL ++E  L  E       ++R+       + +PK  L     +  +LK MG +D+F    A L+ I+ AP  +  V     + +NE           E  +     G       MP      AN PFL +I ++   +V+ + R++ P
Sbjct:  104 EFKKASKESFSAEMAL--VDYVKNSNGARD-----TVNRWVEQKTKDKIKNLI-PEGMFNK-DTILCLVNAVYFKGSWMKHFNRNATQSGKFKTTPSQEIQVQFMYQSSEFRYLESSTLGCQIVELPYAGEKLSMVVLLPNEVDGLGKLESSLNKETLQEAMTSLRNSHPEEVEVTLPKFTLTQEFSLGETLKGMGASDLFSPGKADLSGISAAPLVVSEVVHKAFVEVNE-----------EGTIAAAATGVGIMLMSMPMNPVFYANHPFLFLIRHNDTGAVLFMGRLVVP 376          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Nematostella
Match: EDO35650 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKW7])

HSP 1 Score: 60.8474 bits (146), Expect = 3.984e-10
Identity = 47/228 (20.61%), Postives = 102/228 (44.74%), Query Frame = 2
Query:  572 SGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHL---TGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPI 1246
            + +TL + I+ K  +   F+ + +   EF  ++S  +++ M+       Y    +   +++   ++    S+++V+P +  GLA  E+ LT +K + +     + R     + IPK  + +   ++ +L+++G+  +FD + A    I+  P  +  VS  +     E      +     + +  M C     M E     A+ PFL +I +     V+ + RV+ P+
Sbjct:  150 TRLTLVNAIYFKGMWDKPFKKEHSHSSEFRTTSSNEVEVEMMFQKSKFKYLHSDKYKCKLLELPYVDTQLSMVLVLPDETEGLARFEQDLTHDKMTDIFNSVSSQRPADVEVYIPKFKMTSEFKLNEALQELGMKKMFDQAAADFTGISLPPEHL-FVSAVLHKAFVEVNEEGTEAAAATAAIMMMRCAI---MREPLVFRADHPFLFLIQHCKSKCVLFMGRVMNPV 373          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Nematostella
Match: EDO35632 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKW8])

HSP 1 Score: 58.5362 bits (140), Expect = 1.958e-9
Identity = 51/227 (22.47%), Postives = 103/227 (45.37%), Query Frame = 2
Query:  614 FCNIFRPDSTEIGEFHV------SASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGI---SINLNE--------FGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            F  +++ +  E   FH       S    I++ M+     + +  D +I  R++   + G + ++++++P +  G+  +EK +  E        M +    ++IPK  L+   ++ + L+ +GV+DIFD   A L+ I+ A     +VS  I    I +NE         G  + KR L  +E++                 A+ PFL  IH+   ++++ + +V++P
Sbjct:  170 FKGVWKKEFGEENTFHAAFFVPESHESKIEVEMMTRKMKVNFYYDADIKCRVVELPYSGDDTAMVIILPEEPSGIFSLEKSIDVEIMEKWRRLMINTTVEVSIPKFRLSQKLELRSLLQDLGVSDIFDSRKADLSGISAAKGL--YVSSAIHKAHIEVNERGTVAAATTGVVMAKRSLDMNEVF----------------YADHPFLFSIHHKPSSAILFLGKVMQP 378          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Medaka
Match: serpind1 (serpin family D member 1 [Source:NCBI gene;Acc:101169612])

HSP 1 Score: 91.6633 bits (226), Expect = 1.522e-19
Identity = 61/256 (23.83%), Postives = 123/256 (48.05%), Query Frame = 2
Query:  476 KDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            +D A ++  N  I+KL+   +K  L   + P   + L +Y++ K ++   F  + T    F ++   ++++PM+ + G  +   D E+   I+   + G N S+L+ +P K  G+  +E++++    +    NM +    + +P+  L    D+  +LK+MG++D+F GS    + +T     +  +    +I +NE G          +E   +   GF  +  Q   V + PFL +I+ H  + +V + RV+ P
Sbjct:  260 RDPAFLEKANSRIQKLTKGLIKDPLKSVD-PNMVLMLLNYLYFKGTWEQKFPKEMTYYRNFRITEKTSVRVPMMANKGNYLAAADHELDCDILQLPYSG-NISMLIALPRKISGMRTLERQISPTVVNKWLKNMTNRTREVLLPRFTLEQSYDLIQNLKEMGLSDMFQGS-GDFSGMTSERVVMSWLKHQGTITVNEEG----------TEAASLTQVGFMPLSSQIRFVVDHPFLFLIYEHRTDCLVFIGRVVNP 502          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Medaka
Match: serpine1 (serpin family E member 1 [Source:NCBI gene;Acc:100529196])

HSP 1 Score: 73.559 bits (179), Expect = 9.400e-14
Identity = 63/291 (21.65%), Postives = 123/291 (42.27%), Query Frame = 2
Query:  392 EFKQENGIYVSSGVALENLDSLK----------------HTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQN-KPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNE---DKEIGARIMYHSFLGCNFSVLVVVPIK-KFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPA-AIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHY 1198
            +   E G+ ++SGV +E   SL+                     K D  V ++N  +   +   ++ FL   +   ++ + L + +H +  +   F P  T+   FH +    + +PM++      Y E      +   ++   + G   S+L+V P +    L  +   L+++K       MR V   LA+P+ +LN+  ++  +L KMG+ D+F+ + A   +IT      +  V Q ++I +NE G                    F+ M  ++ I+ + PFL +I +
Sbjct:  149 DLASEEGVNIASGVMVERKMSLEKGYRRALAKTFQTYPHQVDFTKSDQAVNIINAWVSDHTAGSIQDFLASGSLSDETRMVLLNALHFQGLWKVPFNPKLTQERMFHCANGSKVPVPMMRLTNRFNYGEFVTSDGVDYDVIEVPYEGDTLSMLLVSPFEHDVPLGMLSADLSSQKIRQWRSEMRKVNRQLAMPRFSLNSEVNMKTALHKMGLGDMFNLATADFTRITSDERLCVSKVLQRVTIEVNEQGTKAAAATAAVM---------FSRMAVEE-IILDRPFLFLIQH 429          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Medaka
Match: si:ch1073-416d2.3 (serpin family A member 10 [Source:NCBI gene;Acc:101158316])

HSP 1 Score: 66.2402 bits (160), Expect = 2.037e-11
Identity = 52/253 (20.55%), Postives = 116/253 (45.85%), Query Frame = 2
Query:  488 GVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPA-AIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
             +K +N+ + + +  ++   ++  N   + + L + I  +  +   F P+ TE   FH+     +++PM+         ED+ +GAR++   +     S+L+++P KK     ++ ++TA+++     N+  +   + +PK  +     +   L +MG++ +F    A+L +++KA A  +  V     I ++E G +           Y         +P +  I  N PF   I++   N+++ + RV+ P
Sbjct:  163 SIKTINDYVRQKTADKVPEMISTLNA-MTKLLLINTIFFQGVWQIPFNPNFTENAPFHIDNYNIVQVPMMFVEDKFYTMEDEPLGARVLKLPY-KEGVSMLILLPNKKTDYTTIDNEITAQRFLSWIRNLEPMKLEVNMPKFKMERAYSLHNILPEMGMSSLF-TDFANLTRLSKAQALRVSEVLHKAVIEVDEVGTTAAAATATGIIPYA--------LPRRFTI--NRPFFFFIYHEETNALLFMGRVINP 402          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Medaka
Match: serpini1 (serpin family I member 1 [Source:NCBI gene;Acc:101172921])

HSP 1 Score: 62.3882 bits (150), Expect = 3.529e-10
Identity = 52/259 (20.08%), Postives = 109/259 (42.08%), Query Frame = 2
Query:  500 LNEEIEKLSGHRLKSFLNPQN-KPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNE----DKEIGA--RIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQ----QDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            +N  +E  +  +++S L+ ++    + +TL + I+ + S+ N FRP++T    F       ++  M+   G   Y E     +E G   +++   + G + S+++V+P ++  LA +E  + A        N++     + +P+  ++   D+  +L+++G+  IF       A        I    Q   + + E GA             G    G   +         ++A+ PF  +I      SV+ + RV+ P
Sbjct:  157 INSWVENHTESKIRSLLSAEDFSSVTRLTLVNAIYFRGSWKNQFRPENTRTFSFSRDDGSEVQTLMMYQQGDFYYGEFSDGSQEAGGVYQVLEMPYEGEDMSMMIVLPRQEVPLASLEPIIKAPLLEEWANNVKPQKVEIYLPRFKVDQKMDLRDTLQELGIKSIFTTDADLSAMTDGKDLYIGKAVQKAYLEVTEEGAE------------GAVGSGMIALTRTLVLYPQVMADHPFFFVIRNRRTGSVLFMGRVMTP 403          
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Medaka
Match: si:ch1073-416d2.3 (serpin family A member 10 [Source:NCBI gene;Acc:101158316])

HSP 1 Score: 59.6918 bits (143), Expect = 2.627e-9
Identity = 49/253 (19.37%), Postives = 111/253 (43.87%), Query Frame = 2
Query:  488 GVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITK-APAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
             +K +N+ + + +  ++   ++  N   + + L + I  +  +   F P+ TE   FH+    T+++PM+         ED+ +GAR++   +     S+L+++P +     ++  ++ A  + + T N+      + +P+  +     +   L  MG+T +F  ++A+L K++K     +  V     I ++E G +       E   Y                + N PF   I++    +++ V RV++P
Sbjct:  163 SIKTINDYVRQKTADKVPEMISTLNA-MTKLLLINTIFFQGVWQIPFNPNFTENATFHIDNYNTVQVPMMFVEDKFYMVEDEPLGARVLKLPY-KEGVSMLILLPNENADYNKIADEINATMFLNWTSNLEKRKLEVRMPRFHMEQDYLLHNILPDMGLTSLF-TNLANLTKLSKDEDLMVSEVLHKAVIEVDEVGTTAAAATAVEVTRYS-----------SMSFIINRPFFFFIYHEETEALLFVGRVIDP 401          
BLAST of Alpha-1-antiproteinase 2 vs. Planmine SMEST
Match: SMESG000078710.1 (SMESG000078710.1)

HSP 1 Score: 665.226 bits (1715), Expect = 0.000e+0
Identity = 355/356 (99.72%), Postives = 355/356 (99.72%), Query Frame = 2
Query:  188 GKEVCISPXXXXXXXXXXXHSTSSEKVIAQIDKLLHLNXXXXXXXXXXXXXIICDLINHVTNGDKEFVEFKQENGIYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILSE 1255
            GKEVCISPLGILGNLNILIHSTSSEKVIAQIDKLLHLNETEKKKKQDEKVKIICDLINHVTNGDKEFVEFKQENGIYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGM MYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILSE
Sbjct:    5 GKEVCISPLGILGNLNILIHSTSSEKVIAQIDKLLHLNETEKKKKQDEKVKIICDLINHVTNGDKEFVEFKQENGIYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMRMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILSE 360          
BLAST of Alpha-1-antiproteinase 2 vs. Planmine SMEST
Match: SMESG000078710.1 (SMESG000078710.1)

HSP 1 Score: 660.218 bits (1702), Expect = 0.000e+0
Identity = 355/357 (99.44%), Postives = 355/357 (99.44%), Query Frame = 2
Query:  188 GKEVCISPXXXXXXXXXXXHSTSSEKVIAQIDKLLHLNXXXXXXXXXXXXXIICDLINHVTNGDKEFVEFKQENGIYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLA-KITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILSE 1255
            GKEVCISPLGILGNLNILIHSTSSEKVIAQIDKLLHLNETEKKKKQDEKVKIICDLINHVTNGDKEFVEFKQENGIYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGM MYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLA KITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILSE
Sbjct:    5 GKEVCISPLGILGNLNILIHSTSSEKVIAQIDKLLHLNETEKKKKQDEKVKIICDLINHVTNGDKEFVEFKQENGIYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMRMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLASKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEPILSE 361          
BLAST of Alpha-1-antiproteinase 2 vs. Planmine SMEST
Match: SMESG000078713.1 (SMESG000078713.1)

HSP 1 Score: 351.288 bits (900), Expect = 1.529e-119
Identity = 172/178 (96.63%), Postives = 173/178 (97.19%), Query Frame = 2
Query:  476 KDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKIT 1009
            +DDAGVKVLNEEIEKLSGHRLKSFLN QNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGM MYNEDKEIGARIMYHSF GCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLA  T
Sbjct:  109 QDDAGVKVLNEEIEKLSGHRLKSFLNLQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMRMYNEDKEIGARIMYHSFFGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLASST 286          
BLAST of Alpha-1-antiproteinase 2 vs. Planmine SMEST
Match: SMESG000078713.1 (SMESG000078713.1)

HSP 1 Score: 350.903 bits (899), Expect = 2.784e-119
Identity = 172/178 (96.63%), Postives = 173/178 (97.19%), Query Frame = 2
Query:  476 KDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKIT 1009
            +DDAGVKVLNEEIEKLSGHRLKSFLN QNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGM MYNEDKEIGARIMYHSF GCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLA  T
Sbjct:  116 QDDAGVKVLNEEIEKLSGHRLKSFLNLQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMRMYNEDKEIGARIMYHSFFGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLASST 293          
BLAST of Alpha-1-antiproteinase 2 vs. Planmine SMEST
Match: SMESG000078707.1 (SMESG000078707.1)

HSP 1 Score: 229.18 bits (583), Expect = 7.570e-71
Identity = 137/375 (36.53%), Postives = 214/375 (57.07%), Query Frame = 2
Query:  119 MTSTDHSHILNELAFGLLKESDQGKEVCISPXXXXXXXXXXXHSTSSEKVIAQIDKLLHLNXXXXXXXXXXXXXIICDLINHVTNGDKEFVEFKQENGIYVSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKPKSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLMYNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLTGNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAPAAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVANEPFLLIIHYHVGNSVVSVNRVLEP 1243
            M S + + ILNE++F LLK  DQ + +C SPL IL   N L+  T S  ++ +I  L   + +  +  Q EKV  + + IN +   D   ++ K   G++VS    L         K C+ +  V ++NEEI +++  ++K FLN ++KP++G+  FS +H+K  F ++F+  S  + +FH+ AS   K+ M+ S GM  Y EDKEI A+IM H     + S+LV+VPIK+FGL E+ K LT +KY  +   M+ V+GSL+IP  ++N   D     +K     +   S    +K       +DH  QG +I +N+FG ++   E +  E+ G C GGFT  PE+Q+I+A+EPFL+I+  H  N ++S+ RV EP
Sbjct:    1 MNSNNDAQILNEISFSLLKTFDQNEVICFSPLSILATFNALLQFTPSNSLVQEIGDLFKFDCSWNELSQFEKVNWVTNFINKILIDDSSVLKLKY--GVWVSRDKQLRFDFVNSDIKFCQSNESVGIINEEILQMTDEKIKDFLNNKHKPQTGLVSFSVLHLKGHFLHLFKTSS--VADFHLDASNCKKVTMMTSFGMFKYVEDKEINAKIMNHYLSDGSLSLLVIVPIKRFGLTEIVKNLTVDKYRSMIDGMKLVVGSLSIPAFSMNCSADYLKHFQKCNANKL---STISSSKAKNEIDHVDHFIQGTAIAVNDFGVNLSISEKRPFEVSGPCMGGFTTPPERQEILADEPFLIILTNHKENYIISMIRVTEP 368          
The following BLAST results are available for this feature:
BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SERPIND11.143e-1625.10serpin family D member 1 [Source:HGNC Symbol;Acc:H... [more]
SERPIND11.143e-1625.10serpin family D member 1 [Source:HGNC Symbol;Acc:H... [more]
SERPINI28.361e-1520.38serpin family I member 2 [Source:HGNC Symbol;Acc:H... [more]
SERPINI28.361e-1520.38serpin family I member 2 [Source:HGNC Symbol;Acc:H... [more]
SERPINI28.361e-1520.38serpin family I member 2 [Source:HGNC Symbol;Acc:H... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
srp-23.731e-1022.56SeRPin [Source:UniProtKB/TrEMBL;Acc:O17365][more]
srp-23.731e-1022.56SeRPin [Source:UniProtKB/TrEMBL;Acc:O17365][more]
srp-82.294e-923.32SeRPin [Source:UniProtKB/TrEMBL;Acc:Q19651][more]
srp-11.924e-822.75SeRPin; Serine or cysteine protease inhibitor [So... [more]
srp-73.128e-824.00SeRPin; Serine or cysteine protease inhibitor [So... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Spn47C4.980e-2024.80gene:FBgn0033574 transcript:FBtr0300862[more]
Spn47C4.980e-2024.80gene:FBgn0033574 transcript:FBtr0088211[more]
Spn47C4.980e-2024.80gene:FBgn0033574 transcript:FBtr0345584[more]
Spn43Aa4.832e-1522.39gene:FBgn0024294 transcript:FBtr0089041[more]
Spn42Da8.543e-1321.99gene:FBgn0265137 transcript:FBtr0086204[more]
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
serpind17.060e-2025.88serpin peptidase inhibitor, clade D (heparin cofac... [more]
serpind17.060e-2025.88serpin peptidase inhibitor, clade D (heparin cofac... [more]
si:ch1073-416d2.35.449e-1321.34si:ch1073-416d2.3 [Source:ZFIN;Acc:ZDB-GENE-131127... [more]
serpine12.946e-1222.17serpin peptidase inhibitor, clade E (nexin, plasmi... [more]
serpina10a3.095e-1219.92serpin peptidase inhibitor, clade A (alpha-1 antip... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
serpind11.592e-1625.50serpin peptidase inhibitor, clade D (heparin cofac... [more]
marveld31.590e-1422.51MARVEL domain containing 3 [Source:Xenbase;Acc:XB-... [more]
SERPINA107.809e-1323.41serpin peptidase inhibitor, clade A (alpha-1 antip... [more]
SERPINH12.479e-1121.81serpin peptidase inhibitor, clade H (heat shock pr... [more]
ENSXETT00000048100.12.817e-1123.56serine (or cysteine) proteinase inhibitor, clade A... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Serpind17.966e-1623.14serine (or cysteine) peptidase inhibitor, clade D,... [more]
Serpind17.966e-1623.14serine (or cysteine) peptidase inhibitor, clade D,... [more]
Serpina1e9.408e-1627.48serine (or cysteine) peptidase inhibitor, clade A,... [more]
Serpina1e9.408e-1627.48serine (or cysteine) peptidase inhibitor, clade A,... [more]
Serpinb9g4.560e-1422.37serine (or cysteine) peptidase inhibitor, clade B,... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5MGH0|SPI3_LONON5.760e-1725.00Serine protease inhibitor 3/4 (Fragment) OS=Lonomi... [more]
sp|P05546|HEP2_HUMAN5.491e-1625.10Heparin cofactor 2 OS=Homo sapiens OX=9606 GN=SERP... [more]
sp|P47776|HEP2_RABIT2.048e-1522.48Heparin cofactor 2 OS=Oryctolagus cuniculus OX=998... [more]
sp|P49182|HEP2_MOUSE5.572e-1523.14Heparin cofactor 2 OS=Mus musculus OX=10090 GN=Ser... [more]
sp|Q00898|A1AT5_MOUSE6.581e-1527.48Alpha-1-antitrypsin 1-5 OS=Mus musculus OX=10090 G... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3B3RAX45.659e-2126.80Serpin peptidase inhibitor, clade D (heparin cofac... [more]
W5M2R71.750e-1926.17Serpin peptidase inhibitor, clade D (heparin cofac... [more]
B4MDT69.362e-1924.71SERPIN domain-containing protein OS=Drosophila vir... [more]
A0A401SAN71.986e-1827.84SERPIN domain-containing protein OS=Chiloscyllium ... [more]
A0A1B6I7224.721e-1827.27SERPIN domain-containing protein OS=Homalodisca li... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
serpind13.280e-1723.48serpin family D member 1 [Source:NCBI gene;Acc:103... [more]
si:ch1073-416d2.33.358e-1420.45protein Z-dependent protease inhibitor-like [Sourc... [more]
serpinc11.382e-1222.94serpin family C member 1 [Source:NCBI gene;Acc:103... [more]
serpine11.727e-1222.80serpin family E member 1 [Source:NCBI gene;Acc:103... [more]
serpinh1b7.292e-1121.29serpin H1-like [Source:NCBI gene;Acc:103039097][more]
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
serpind14.500e-1524.81serpin peptidase inhibitor, clade D (heparin cofac... [more]
ENSPMAT00000006795.11.581e-1323.94pep scaffold:Pmarinus_7.0:GL479006:3227:9631:1 gen... [more]
serpinf15.458e-1128.67serpin peptidase inhibitor, clade F (alpha-2 antip... [more]
serpinh1a5.288e-622.51serpin peptidase inhibitor, clade H (heat shock pr... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO402881.226e-1523.21Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO356503.984e-1020.61Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO356321.958e-922.47Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
serpind11.522e-1923.83serpin family D member 1 [Source:NCBI gene;Acc:101... [more]
serpine19.400e-1421.65serpin family E member 1 [Source:NCBI gene;Acc:100... [more]
si:ch1073-416d2.32.037e-1120.55serpin family A member 10 [Source:NCBI gene;Acc:10... [more]
serpini13.529e-1020.08serpin family I member 1 [Source:NCBI gene;Acc:101... [more]
si:ch1073-416d2.32.627e-919.37serpin family A member 10 [Source:NCBI gene;Acc:10... [more]
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BLAST of Alpha-1-antiproteinase 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000078710.10.000e+099.72SMESG000078710.1[more]
SMESG000078710.10.000e+099.44SMESG000078710.1[more]
SMESG000078713.11.529e-11996.63SMESG000078713.1[more]
SMESG000078713.12.784e-11996.63SMESG000078713.1[more]
SMESG000078707.17.570e-7136.53SMESG000078707.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30016156 ID=SMED30016156|Name=Alpha-1-antiproteinase 2|organism=Schmidtea mediterranea sexual|type=transcript|length=1356bp
CTAATTGGTCCAATTTTTATTGATTTATGTTAGTAAAATGCAGACAATTT
GTATGATGAATAAATACAAGCGCGAGTGGGCTTTAGATTTATTATTCATT
TGAAAATAAGAATTAAAAATGACTTCAACCGATCATTCTCATATACTTAA
TGAATTGGCTTTTGGTCTATTAAAGGAATCAGATCAAGGTAAAGAAGTGT
GCATTTCTCCATTGGGCATTTTGGGAAATCTAAACATCTTGATCCATTCA
ACTTCCTCTGAGAAAGTTATTGCCCAAATCGACAAGCTGCTTCATCTCAA
TGAAACTGAGAAAAAGAAAAAACAAGACGAGAAAGTGAAAATAATTTGCG
ATCTAATTAATCATGTCACTAATGGTGATAAAGAATTTGTCGAATTTAAA
CAAGAAAATGGTATTTATGTTTCATCTGGAGTTGCATTAGAAAATTTGGA
TTCATTGAAACACACTAAAATCTGCAAAGATGATGCCGGAGTAAAGGTCT
TAAATGAAGAAATTGAAAAATTATCTGGGCATCGATTAAAATCTTTTCTA
AATCCTCAAAATAAACCGAAAAGTGGCGTGACGTTGTTCAGTTATATTCA
TATAAAGGCCTCATTTTGCAACATATTCCGTCCAGATTCCACAGAAATTG
GTGAATTCCATGTCAGTGCATCGAAAACTATTAAAATCCCAATGCTAAAA
TCCGGTGGAATGCTCATGTATAATGAAGATAAAGAAATTGGAGCTCGAAT
AATGTATCACAGTTTTCTCGGTTGCAATTTCAGCGTCTTGGTTGTCGTGC
CAATAAAAAAATTCGGCCTCGCTGAAATGGAGAAGAAACTTACGGCAGAA
AAATATTCTCATTTAACTGGAAATATGAGATCTGTTTTAGGGTCGCTGGC
GATTCCAAAATTAGCTTTGAATAATGTTACTGATGTTAGCGCATCCTTGA
AAAAAATGGGCGTTACGGATATATTTGATGGCTCTGTGGCGCACCTTGCA
AAAATAACGAAAGCACCAGCAGCCATAGATCATGTGAGTCAAGGAATTTC
AATAAATTTAAATGAATTTGGGGCCAGTGTTCCGAAAAGAGAATTGAAAG
AATCAGAAATGTATGGCATGTGCTGTGGGGGATTCACAGAGATGCCAGAA
CAACAAGATATCGTTGCTAACGAACCTTTTCTTTTAATAATTCATTACCA
CGTTGGAAACTCTGTGGTGTCAGTTAATAGAGTTTTGGAGCCGATTCTTT
CTGAATGATAGTATAAAATTAACTTAGTAAACTATATATTTTCAAACTTA
TATTATTATATCTGCTTGTGTTTGGTGAAAACATTTATACATTTTTATAA
TAAAAT
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protein sequence of SMED30016156-orf-1

>SMED30016156-orf-1 ID=SMED30016156-orf-1|Name=SMED30016156-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=380bp
MTSTDHSHILNELAFGLLKESDQGKEVCISPLGILGNLNILIHSTSSEKV
IAQIDKLLHLNETEKKKKQDEKVKIICDLINHVTNGDKEFVEFKQENGIY
VSSGVALENLDSLKHTKICKDDAGVKVLNEEIEKLSGHRLKSFLNPQNKP
KSGVTLFSYIHIKASFCNIFRPDSTEIGEFHVSASKTIKIPMLKSGGMLM
YNEDKEIGARIMYHSFLGCNFSVLVVVPIKKFGLAEMEKKLTAEKYSHLT
GNMRSVLGSLAIPKLALNNVTDVSASLKKMGVTDIFDGSVAHLAKITKAP
AAIDHVSQGISINLNEFGASVPKRELKESEMYGMCCGGFTEMPEQQDIVA
NEPFLLIIHYHVGNSVVSVNRVLEPILSE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0000101muscle cell
PLANA:0000418head
PLANA:0000420parapharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR042185Serpin_sf_2
IPR042178Serpin_sf_1
IPR000215Serpin_fam
IPR036186Serpin_sf
IPR023796Serpin_dom
Vocabulary: molecular function
TermDefinition
GO:0001948glycoprotein binding
GO:0002020protease binding
GO:0004867serine-type endopeptidase inhibitor activity
GO:0030414peptidase inhibitor activity
GO:0042802identical protein binding
Vocabulary: cellular component
TermDefinition
GO:0005576extracellular region
GO:0005615extracellular space
GO:0005783endoplasmic reticulum
GO:0005794Golgi apparatus
GO:0043231intracellular membrane-bounded organelle
GO:0070062extracellular exosome
Vocabulary: biological process
TermDefinition
GO:0010466negative regulation of peptidase activity
GO:0010951negative regulation of endopeptidase activity
GO:0034097response to cytokine
GO:0043434response to peptide hormone
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR023796Serpin domainSMARTSM00093serpin2coord: 15..293
e-value: 2.0E-5
score: -73.8
IPR023796Serpin domainPFAMPF00079Serpincoord: 11..293
e-value: 1.7E-31
score: 109.8
IPR042185Serpin superfamily, domain 2GENE3DG3DSA:2.30.39.10coord: 166..262
e-value: 1.3E-32
score: 115.4
IPR042178Serpin superfamily, domain 1GENE3DG3DSA:3.30.497.10coord: 22..291
e-value: 1.3E-32
score: 115.4
NoneNo IPR availablePANTHERPTHR11461:SF211ACCESSORY GLAND PROTEIN ACP76A-RELATEDcoord: 12..292
IPR000215Serpin familyPANTHERPTHR11461SERINE PROTEASE INHIBITOR, SERPINcoord: 12..292
IPR036186Serpin superfamilySUPERFAMILYSSF56574Serpinscoord: 6..291