lissencephaly-1

Overview


Name	lissencephaly-1 (AFH96442.1)
Smed ID	SMED30016141
Length (bp)	1602

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of lissencephaly-1 (SMED30016141) t-SNE clustered cells

Violin plots show distribution of expression levels for lissencephaly-1 (SMED30016141) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of lissencephaly-1 (SMED30016141) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for lissencephaly-1 (SMED30016141) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30016141

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30016141	SMESG000054739.1 SMESG000035997.1	JQ650355.1	smed_ncbi_20200123	PMID:22411224 Cowles et al., 2012
gut	SMED30016141	SMESG000054739.1 SMESG000035997.1	JQ650355.1	smed_ncbi_20200123	PMID:22411224 Cowles et al., 2012
central nervous system	SMED30016141	SMESG000054739.1 SMESG000035997.1	JQ650355.1	smed_ncbi_20200123	PMID:22411224 Cowles et al., 2012
neoblast	SMED30016141	SMESG000054739.1 SMESG000035997.1	JQ650355.1	smed_ncbi_20200123	PMID:22411224 Cowles et al., 2012
parenchyma	SMED30016141	SMESG000054739.1 SMESG000035997.1	JQ650355.1	smed_ncbi_20200123	PMID:22411224 Cowles et al., 2012
nervous system	SMED30016141	SMESG000054739.1 SMESG000035997.1	dd_Smed_v4_3359_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of lissencephaly-1 vs. Ensembl Human
Match: PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1 [Source:HGNC Symbol;Acc:HGNC:8574])

HSP 1 Score: 544.658 bits (1402), Expect = 0.000e+0
Identity = 251/427 (58.78%), Postives = 330/427 (77.28%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAK--ILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA+  +  E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E     ++    G+K    +W+PR P ++ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A KECK + REHEHVV+CI W  +  +   ++A   + + +                   L SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FH  GKF+LS +DDKT+R+WD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----FTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGP-------------FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. Ensembl Human
Match: PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1 [Source:HGNC Symbol;Acc:HGNC:8574])

HSP 1 Score: 221.861 bits (564), Expect = 5.519e-69
Identity = 105/214 (49.07%), Postives = 145/214 (67.76%), Query Frame = 3

Query:  561 SADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKM-SGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLK 1199
            SADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A KECK + REHEHVV+CI W  +  +   ++A        S     N + G    SG   + S + D+T+R+WD     C+  L  H ++V  L FH    ++++ S D+T+++W+ +
Sbjct:    1 SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEA------TGSEVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 208

HSP 2 Score: 150.984 bits (380), Expect = 6.012e-42
Identity = 88/241 (36.51%), Postives = 119/241 (49.38%), Query Frame = 3

Query:  687 SRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNL----------------------------IGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            S D TIKLW+     C++T  GH   V  V    +G  I S S D ++++W +    C   F  H   V                     + +  N D +            L+AS S D+T+R+W   T  C   L                            +GH+NWV+ ++FH  GKF+LS +DDKT+R+WD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWV---------------------RMVRPNQDGT------------LIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSEVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 208

HSP 3 Score: 92.4337 bits (228), Expect = 8.117e-21
Identity = 56/176 (31.82%), Postives = 85/176 (48.30%), Query Frame = 3

Query:  366 LKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVV 893
            + GH  +++ V   P  +  VS S D TIK+W+ ++G   +T  GH   V+ +  +  G L+ASCS D  +++W      C   L  H+H V  +S+ P   +   +           +TG  V    GH +WVR V  +  G  I SC++D ++RVW   NK C      HEH V
Sbjct:   20 MHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE----------ATGSEV----GHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 181

HSP 4 Score: 68.9366 bits (167), Expect = 1.084e-12
Identity = 38/145 (26.21%), Postives = 68/145 (46.90%), Query Frame = 3

Query:  366 LKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLR----------------------------GHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWE 716
              GHR  +  VR +    +  S S D T+++W   + + +  LR                            GH N V+ + F   GK + SC+ D  +++WD+    C+KTL+ H+H V+ + F  +  ++++ S D+T+K+WE
Sbjct:   62 FTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSEVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 206

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BLAST of lissencephaly-1 vs. Ensembl Human
Match: DAW1 (dynein assembly factor with WD repeats 1 [Source:HGNC Symbol;Acc:HGNC:26383])

HSP 1 Score: 168.318 bits (425), Expect = 4.326e-46
Identity = 101/320 (31.56%), Postives = 152/320 (47.50%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFH-PLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            + L+GHR  +  + F+ P  +   +GS D T K+W  E+G    T RGHT  +  L+F+P   L+A+ S D   KLWD      V TL GH   +  +SF  SGD +++ S D T+ +W+  TG  V    GH   +     N+D SLI + S D + ++W   N +C      H                       DD+ + S  D + KL          +A+ S D T R++   T  C+  L GH   + ++ F+PQG  LL+ S DKT RIWD +  +C + LE H   + +  F+     V+TGS D   ++W
Sbjct:  128 NTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGH-----------------------DDEILDSCFDYTGKL----------IATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414

HSP 2 Score: 153.68 bits (387), Expect = 7.662e-41
Identity = 99/325 (30.46%), Postives = 152/325 (46.77%), Query Frame = 3

Query:  363 VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAF-DPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR*SQ 1334
            VLK H   +T V  +   + F++GS D T K+WD  SG+   TL GH N V  +AF +P G  +A+ S D   KLW      C  T  GH   +  +SF P    + + S D T KLW++  G  V T  GHS  +  +  N  G  I + S D++V VW                        G+K+++       +    + N D            C L+ +GS D+T +LWD   G C+  L GH++ + +  F   GK + +AS D T RI+    R+C   LE H+  ++ I F+    +++TGS D+  ++W+ +  Q
Sbjct:   87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT--------------------GRKVNILIGHC-AEISSASFNWD------------CSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378

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BLAST of lissencephaly-1 vs. Ensembl Human
Match: WDR5 (WD repeat domain 5 [Source:HGNC Symbol;Acc:HGNC:12757])

HSP 1 Score: 162.155 bits (409), Expect = 1.016e-44
Identity = 104/361 (28.81%), Postives = 170/361 (47.09%), Query Frame = 3

Query:  261 QETKKETHDVISNAT--FKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFH----PQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVWE 1319
            +E K ET    +  T      +S      P    +  L GH  +++ V+F P      S S D  IKIW    G +E+T+ GH   + D+A+     LL S S D  +K+WD     C+KTL GH + V   +F P  + ++S S D+++++W+V TG C++T   HSD V  V  N DGSLI S S D   R+W  A+ +C                          + L+DD     +         +  +G ++LA+ + D T++LWD + G CL    GH N  +  +F       GK+++S S+D  + IW+L+ +   + L+ H   V +   H     + + ++  D+ +K+W+
Sbjct:    4 EEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL-------------------------KTLIDDDNPPVS------FVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331

HSP 2 Score: 150.599 bits (379), Expect = 1.877e-40
Identity = 97/287 (33.80%), Postives = 144/287 (50.17%), Query Frame = 3

Query:  489 TLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELV-FHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAH--DHFVTTIDFH-RNSPYVVTGSVDQIVKVWECR*SQI 1337
            TL GHT  V  + F P+G+ LAS SAD  IK+W   +    KT+SGH   +S V++    + L+SAS DKT+K+W+VS+G C++T +GHS++V     N   +LI S S D SVR+W +   +C      H   V         +H               N D S            L+ S S D   R+WDT +G CL  LI  +N     V F P GK++L+A+ D T+++WD    +C KT   H  + +    +F      ++V+GS D +V +W  +  +I
Sbjct:   40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA-------VHF--------------NRDGS------------LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293

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BLAST of lissencephaly-1 vs. Ensembl Human
Match: WDR5B (WD repeat domain 5B [Source:HGNC Symbol;Acc:HGNC:17826])

HSP 1 Score: 157.532 bits (397), Expect = 4.360e-43
Identity = 105/356 (29.49%), Postives = 164/356 (46.07%), Query Frame = 3

Query:  273 KETHDVISNATFK--GRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFH----PQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVW 1316
            KE+ D  +         +S  V   P    +  L GH  +++ V+F P      S S D  I IW    G YE+TL GH   + D+A+      L S S D  +KLWD     C+KTL GH + V   +F P  + ++S S D+T+K+WEV TG C++T   HSD V  V  N  GSLI S S D   R+W  A+ +C                          + L+DD       +       +  +G ++L + + D T++LWD + G CL    GH N  +  +F       GK+++S S+D  + IW+L+ +   + L+ H   V +   H     + + ++  D+ +K+W
Sbjct:    4 KESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL-------------------------KTLVDDD------NPPVSFVKFSPNGKYIL-TATLDNTLKLWDYSRGRCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326

HSP 2 Score: 144.436 bits (363), Expect = 3.845e-38
Identity = 92/287 (32.06%), Postives = 140/287 (48.78%), Query Frame = 3

Query:  489 TLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELV-FHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAH--DHFVTTIDFH-RNSPYVVTGSVDQIVKVWECR*SQI 1337
            TL GHT  V  + F P+G+ LAS SAD  I +W   +    KTL GH+  +S V++      L+SAS DKT+KLW+V +G C++T +GHS++V     N   +LI S S D +V++W +   +C      H   V  +                                 +  SG  L+ SGS D   R+WD  +G CL  L+  +N     V F P GK++L+A+ D T+++WD    RC KT   H  + +    +F      ++V+GS D +V +W  +  +I
Sbjct:   36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAV--------------------------------HFNCSG-SLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 289

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BLAST of lissencephaly-1 vs. Ensembl Celegans
Match: lis-1 (Lissencephaly-1 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q9NDC9])

HSP 1 Score: 463.381 bits (1191), Expect = 9.573e-161
Identity = 219/426 (51.41%), Postives = 298/426 (69.95%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVE-FTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            M LSERQ EE+N++IAEY+ +NGY E++++F  E+ +     K   G+LEKKWT+V+RLQ+KVNDLES+LQE+++E    I++      K  + DW+PR P    L GHR  IT V FHPL+ +  S SEDATIK+WDYE+G  ERTL+GHT+ V D+A D +GK L SCS+D+ IKLWDF + + C+K+L GH+H VS V+F+P+GD +LSASRD TIK W++STGYCV TF GH+DWVR+++ + DG+L AS S D +V VWS A K  K   R+HEH V+C+ W         + A  +       G+S+           H+L SGSRDR+I+ W+ NTG  LF L+ H NWV+ L FHP+GK+L+S +DDKT+R+W+L  +RC K +EAH+HFV+T+ FH+ SP+V+TGSVD   KVWECR
Sbjct:    1 MSLSERQKEEINRAIAEYMQNNGYSESFSVFLKESSLSENDIKPLGGILEKKWTTVLRLQRKVNDLESKLQESQRE----INHGAPTRDKRQAADWIPRPPETQKLTGHRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLERTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLWDFGQTYDCLKSLKGHEHTVSSVTFLPTGDFVLSASRDHTIKQWDISTGYCVYTFRGHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKSAKLVLRDHEHAVECVEWA-------PDTAYTNVTGQQPEGNST-----------HILFSGSRDRSIKAWNINTGDVLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFHQTSPFVITGSVDMSCKVWECR 404

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BLAST of lissencephaly-1 vs. Ensembl Celegans
Match: wdr-5.1 (WD repeat-containing protein wdr-5.1 [Source:UniProtKB/Swiss-Prot;Acc:Q17963])

HSP 1 Score: 154.451 bits (389), Expect = 6.952e-42
Identity = 102/324 (31.48%), Postives = 159/324 (49.07%), Query Frame = 3

Query:  363 VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFH----PQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVW 1316
             L+GH  SI+  +F P      + S D T+KIW+ +    ERTL GH   V D+A+    + + S S D  +K+++ V     KTL GH++ V   +F P    ++S S D+++++W+V TG C++T   HSD V  V  N DGSLIAS S D  VR+W  AN +C                          + L+DD+      +       +  +G ++LAS + D T++LWD + G  L    GH N  +  +F       GK+++S S+D  I IW+L+ R   + LE H   V   D H     + +G++  D  + +W
Sbjct:   82 TLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWSSDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCI-------------------------KTLVDDE------NPPVAFVKFSPNGKYILAS-NLDSTLKLWDFSKGKTLKQYTGHEN-SKYCIFANFSVTGGKWIISGSEDCKIYIWNLQTREIVQCLEGHTQPVLASDCHPVQNIIASGALEPDNKIHIW 372

HSP 2 Score: 90.1225 bits (222), Expect = 2.319e-19
Identity = 53/193 (27.46%), Postives = 90/193 (46.63%), Query Frame = 3

Query:  741 TFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            T EGH+  +   K +  G  + + S D +V++W+M +  C+     H+  V  I W                                  S    + S S D+T+++++  T      L GHNN+V    F+PQ   ++S S D+++RIWD+K   C KTL AH   V+ + F+R+   + +GS D +V++W+
Sbjct:   82 TLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWS---------------------------------SDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWD 241

HSP 3 Score: 77.411 bits (189), Expect = 3.922e-15
Identity = 36/112 (32.14%), Postives = 68/112 (60.71%), Query Frame = 3

Query:  993 LDGYKMSGC-HLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            +   K S C   L + S D+T+++W+ +  +C   L GH   V ++ +    + ++SASDDKT++I+++   R  KTL+ H+++V   +F+  S  VV+GS D+ V++W+ +
Sbjct:   90 ISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWSSDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIWDVK 201

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Query:  363 VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFH----PQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVW 1316
             L+GH  SI+  +F P      + S D T+KIW+ +    ERTL GH   V D+A+    + + S S D  +K+++ V     KTL GH++ V   +F P    ++S S D+++++W+V TG C++T   HSD V  V  N DGSLIAS S D  VR+W  AN +C                          + L+DD+      +       +  +G ++LAS + D T++LWD + G  L    GH N  +  +F       GK+++S S+D  I IW+L+ R   + LE H   V   D H     + +G++  D  + +W
Sbjct:   82 TLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWSSDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCI-------------------------KTLVDDE------NPPVAFVKFSPNGKYILAS-NLDSTLKLWDFSKGKTLKQYTGHEN-SKYCIFANFSVTGGKWIISGSEDCKIYIWNLQTREIVQCLEGHTQPVLASDCHPVQNIIASGALEPDNKIHIW 372

HSP 2 Score: 90.1225 bits (222), Expect = 2.319e-19
Identity = 53/193 (27.46%), Postives = 90/193 (46.63%), Query Frame = 3

Query:  741 TFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            T EGH+  +   K +  G  + + S D +V++W+M +  C+     H+  V  I W                                  S    + S S D+T+++++  T      L GHNN+V    F+PQ   ++S S D+++RIWD+K   C KTL AH   V+ + F+R+   + +GS D +V++W+
Sbjct:   82 TLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWS---------------------------------SDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWD 241

HSP 3 Score: 77.411 bits (189), Expect = 3.922e-15
Identity = 36/112 (32.14%), Postives = 68/112 (60.71%), Query Frame = 3

Query:  993 LDGYKMSGC-HLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            +   K S C   L + S D+T+++W+ +  +C   L GH   V ++ +    + ++SASDDKT++I+++   R  KTL+ H+++V   +F+  S  VV+GS D+ V++W+ +
Sbjct:   90 ISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWSSDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIWDVK 201

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BLAST of lissencephaly-1 vs. Ensembl Celegans
Match: W07E6.2 (pep chromosome:WBcel235:II:480722:484386:-1 gene:WBGene00021074.1 transcript:W07E6.2a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:W07E6.2)

HSP 1 Score: 137.502 bits (345), Expect = 5.713e-35
Identity = 91/334 (27.25%), Postives = 164/334 (49.10%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGD-YERTLRGHTNHVQDLAF-----DPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKEC-KFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKM--------SGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            H  K H++ + C+ + P      S  ++  I IW+ ++G+   +TL+ H   +  LA+     DP+ +LLASC  D  I +WD V+ T V+ LSGH  +V+ + +   G  + S S+D+T+K+W    G   +   GH+ W+  +  N D +L  SC   +   +     +EC K     +E  ++  + GG+++   ++   L          S N++ G+               +AS S D++++LW   TG  L +L GH   V ++ +    + L+S S D T+++++LK +     L  H   V T+D+      VV+G  D+++K+W
Sbjct:  141 HTCKSHKSWVLCIAWSPDATKIASACKNGEICIWNAKTGEQIGKTLKRHKQWITSLAWQPMHKDPTCRLLASCGKDGNIFIWDTVQGTVVRCLSGHTASVTCLRWGGEG-LIYSGSQDRTVKMWRADDGVMCRNMTGHAHWINTLALNTDYALRTSCFEPSKRCIKPDTVEECQKVAQTRYEAALE--IAGGERLVSGSDDFTLFMWNPKETKQSINRMTGHMQLVNQVVFSPDTRYIASASFDKSVKLWCGRTGKYLASLRGHVGPVYQVAWSADSRLLVSGSADSTLKVFELKTKSLYYDLPGHGDEVFTVDWSPEGTKVVSGGKDKVLKLW 471

HSP 2 Score: 92.8189 bits (229), Expect = 6.471e-20
Identity = 82/359 (22.84%), Postives = 147/359 (40.95%), Query Frame = 3

Query:  411 LYNVFVSGSEDAT-IKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKE-CKFDFREHEHVVQCIVWGGQKIHMETNQALL----DDKQM----TSNGDSSNKLDGYKMS-------GCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELV-----------FHPQ----------------------------GKFLLSASDDKTIRIWDLK-NRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            L N  +  S+D   I  +  E  +   ++R     ++++ F+ + KL+    A  +++        C  ++ GH   V    F P G  L S S D+T+++W++     + T + H  WV  +  + D + IAS   +  + +W+    E      + H+  +  + W  Q +H +    LL     D  +    T  G     L G+  S       G  L+ SGS+DRT+++W  + GV   N+ GH +W+  L            F P                             G+ L+S SDD T+ +W+ K  ++    +  H   V  + F  ++ Y+ + S D+ VK+W
Sbjct:   38 LCNQLLGSSDDPVPISFFTTEGAEIVDSIR---KSLEEIDFETTLKLVYQPQAVFRVR----PVTRCSASIPGHGEPVISAQFSPDGRGLASGSGDQTMRIWDIELELPLHTCKSHKSWVLCIAWSPDATKIASACKNGEICIWNAKTGEQIGKTLKRHKQWITSLAW--QPMHKDPTCRLLASCGKDGNIFIWDTVQGTVVRCLSGHTASVTCLRWGGEGLIYSGSQDRTVKMWRADDGVMCRNMTGHAHWINTLALNTDYALRTSCFEPSKRCIKPDTVEECQKVAQTRYEAALEIAGGERLVSGSDDFTLFMWNPKETKQSINRMTGHMQLVNQVVFSPDTRYIASASFDKSVKLW 387

HSP 3 Score: 71.2478 bits (173), Expect = 6.768e-13
Identity = 40/128 (31.25%), Postives = 63/128 (49.22%), Query Frame = 3

Query:  336 WLPRIPARHV--LKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLW 713
            W P+   + +  + GH   +  V F P      S S D ++K+W   +G Y  +LRGH   V  +A+    +LL S SAD  +K+++    +    L GH   V  V + P G  ++S  +DK +KLW
Sbjct:  344 WNPKETKQSINRMTGHMQLVNQVVFSPDTRYIASASFDKSVKLWCGRTGKYLASLRGHVGPVYQVAWSADSRLLVSGSADSTLKVFELKTKSLYYDLPGHGDEVFTVDWSPEGTKVVSGGKDKVLKLW 471

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BLAST of lissencephaly-1 vs. Ensembl Celegans
Match: wdr-5.2 (WD repeat-containing protein wdr-5.2 [Source:UniProtKB/Swiss-Prot;Acc:Q93847])

HSP 1 Score: 135.576 bits (340), Expect = 6.303e-35
Identity = 96/323 (29.72%), Postives = 148/323 (45.82%), Query Frame = 3

Query:  363 VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNN---WVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVW 1316
            +   H+ SI+ ++F P      SGS D +IKIW  +   YE+TL GH   + + ++    KL+ SCS D  +K++D     CVKTL GH + V    F PSG  + S S D+TI++W    G  + +  GH D V  V  N DG+ +AS S D  VR+W      C     + EH                    +   + + NG              ++LAS + + T++LWD      L    GH N    V        GK+++S S+D  + IW+L+ R   +TL+ H+  V   D H     + + ++  D  +K+W
Sbjct:  102 IPNAHKKSISGIKFSPDGRYMGSGSADCSIKIWRMDF-VYEKTLMGHRLGINEFSWSSDSKLIVSCSDDKLVKVFDVSSGRCVKTLKGHTNYVFCCCFNPSGTLIASGSFDETIRIWCARNGNTIFSIPGHEDPVSSVCFNRDGAYLASGSYDGIVRIWDSTTGTCVKTLIDEEH------------------PPITHVKFSPNGK-------------YILAS-NLNNTLKLWDYQKLRVLKEYTGHENSKYCVAANFSVTGGKWIVSGSEDHKVYIWNLQTREILQTLDGHNTAVMCTDCHPGQNIIASAALEPDMRIKIW 391

HSP 2 Score: 103.605 bits (257), Expect = 1.084e-23
Identity = 69/247 (27.94%), Postives = 113/247 (45.75%), Query Frame = 3

Query:  582 LWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDH-FVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            LW   +    +  + H  ++SG+ F P G ++ S S D +IK+W +   Y  +T  GH   +     + D  LI SCS+D  V+V+ +++  C    + H + V C                                  +  SG  L+ASGS D TIR+W    G  +F++ GH + V  + F+  G +L S S D  +RIWD     C KTL   +H  +T + F  N  Y++  +++  +K+W+
Sbjct:   92 LWPTYKLV-AEIPNAHKKSISGIKFSPDGRYMGSGSADCSIKIWRMDFVY-EKTLMGHRLGINEFSWSSDSKLIVSCSDDKLVKVFDVSSGRCVKTLKGHTNYVFCCC--------------------------------FNPSGT-LIASGSFDETIRIWCARNGNTIFSIPGHEDPVSSVCFNRDGAYLASGSYDGIVRIWDSTTGTCVKTLIDEEHPPITHVKFSPNGKYILASNLNNTLKLWD 303

HSP 3 Score: 65.0846 bits (157), Expect = 4.077e-11
Identity = 31/100 (31.00%), Postives = 58/100 (58.00%), Query Frame = 3

Query: 1026 LASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            + SGS D +I++W  +  V    L+GH   + E  +    K ++S SDDK ++++D+ + RC KTL+ H ++V    F+ +   + +GS D+ +++W  R
Sbjct:  122 MGSGSADCSIKIWRMDF-VYEKTLMGHRLGINEFSWSSDSKLIVSCSDDKLVKVFDVSSGRCVKTLKGHTNYVFCCCFNPSGTLIASGSFDETIRIWCAR 220

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BLAST of lissencephaly-1 vs. Ensembl Fly
Match: Lis-1 (gene:FBgn0015754 transcript:FBtr0087241)

HSP 1 Score: 508.449 bits (1308), Expect = 3.133e-178
Identity = 244/427 (57.14%), Postives = 323/427 (75.64%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVE-FTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQAL-LDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ EELN++IA+YL  NGY ++   F+ EA +  E++KKF GLLEKKWTSVIRLQKKV +LE++L E +KE   VI  A  K +++   +W+PR P +  L GHRASIT V FHP++ + VS SEDATI+IWD+E+G+YER+L+GHT+ VQD+AFD  GKLLASCSAD+ IKLWDF + + C+KT+ GHDHNVS V+F+P+GD++LSASRD+TIK+WEV+TGYCV+T+ GH +WVR+V+ + +GS+ A+CSND ++RVW   +K+CK + R+HEH V+CI W  +      N+A   D+K+    G                LASGSRD+TIR+WD + G+CL  L GH+NWV+ L FHP GK+L+SASDDKTIR+WDL+N+RC KTL AH HF T+IDFH+  PYV++GSVDQ VKVWECR
Sbjct:    3 MVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTEVEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKE---VIEGAPTKNKRTPG-EWIPRPPEKFSLTGHRASITRVIFHPIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGP--------------FLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVWDLRNKRCMKTLYAHQHFCTSIDFHKAHPYVISGSVDQTVKVWECR 411

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BLAST of lissencephaly-1 vs. Ensembl Fly
Match: Lis-1 (gene:FBgn0015754 transcript:FBtr0304747)

HSP 1 Score: 508.449 bits (1308), Expect = 3.133e-178
Identity = 244/427 (57.14%), Postives = 323/427 (75.64%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVE-FTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQAL-LDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ EELN++IA+YL  NGY ++   F+ EA +  E++KKF GLLEKKWTSVIRLQKKV +LE++L E +KE   VI  A  K +++   +W+PR P +  L GHRASIT V FHP++ + VS SEDATI+IWD+E+G+YER+L+GHT+ VQD+AFD  GKLLASCSAD+ IKLWDF + + C+KT+ GHDHNVS V+F+P+GD++LSASRD+TIK+WEV+TGYCV+T+ GH +WVR+V+ + +GS+ A+CSND ++RVW   +K+CK + R+HEH V+CI W  +      N+A   D+K+    G                LASGSRD+TIR+WD + G+CL  L GH+NWV+ L FHP GK+L+SASDDKTIR+WDL+N+RC KTL AH HF T+IDFH+  PYV++GSVDQ VKVWECR
Sbjct:    3 MVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTEVEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKE---VIEGAPTKNKRTPG-EWIPRPPEKFSLTGHRASITRVIFHPIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGP--------------FLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVWDLRNKRCMKTLYAHQHFCTSIDFHKAHPYVISGSVDQTVKVWECR 411

[Close]

BLAST of lissencephaly-1 vs. Ensembl Fly
Match: Lis-1 (gene:FBgn0015754 transcript:FBtr0087240)

HSP 1 Score: 508.449 bits (1308), Expect = 3.133e-178
Identity = 244/427 (57.14%), Postives = 323/427 (75.64%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVE-FTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQAL-LDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ EELN++IA+YL  NGY ++   F+ EA +  E++KKF GLLEKKWTSVIRLQKKV +LE++L E +KE   VI  A  K +++   +W+PR P +  L GHRASIT V FHP++ + VS SEDATI+IWD+E+G+YER+L+GHT+ VQD+AFD  GKLLASCSAD+ IKLWDF + + C+KT+ GHDHNVS V+F+P+GD++LSASRD+TIK+WEV+TGYCV+T+ GH +WVR+V+ + +GS+ A+CSND ++RVW   +K+CK + R+HEH V+CI W  +      N+A   D+K+    G                LASGSRD+TIR+WD + G+CL  L GH+NWV+ L FHP GK+L+SASDDKTIR+WDL+N+RC KTL AH HF T+IDFH+  PYV++GSVDQ VKVWECR
Sbjct:    3 MVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTEVEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKE---VIEGAPTKNKRTPG-EWIPRPPEKFSLTGHRASITRVIFHPIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGP--------------FLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVWDLRNKRCMKTLYAHQHFCTSIDFHKAHPYVISGSVDQTVKVWECR 411

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BLAST of lissencephaly-1 vs. Ensembl Fly
Match: Lis-1 (gene:FBgn0015754 transcript:FBtr0087236)

HSP 1 Score: 508.449 bits (1308), Expect = 3.133e-178
Identity = 244/427 (57.14%), Postives = 323/427 (75.64%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVE-FTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQAL-LDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ EELN++IA+YL  NGY ++   F+ EA +  E++KKF GLLEKKWTSVIRLQKKV +LE++L E +KE   VI  A  K +++   +W+PR P +  L GHRASIT V FHP++ + VS SEDATI+IWD+E+G+YER+L+GHT+ VQD+AFD  GKLLASCSAD+ IKLWDF + + C+KT+ GHDHNVS V+F+P+GD++LSASRD+TIK+WEV+TGYCV+T+ GH +WVR+V+ + +GS+ A+CSND ++RVW   +K+CK + R+HEH V+CI W  +      N+A   D+K+    G                LASGSRD+TIR+WD + G+CL  L GH+NWV+ L FHP GK+L+SASDDKTIR+WDL+N+RC KTL AH HF T+IDFH+  PYV++GSVDQ VKVWECR
Sbjct:    3 MVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTEVEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKE---VIEGAPTKNKRTPG-EWIPRPPEKFSLTGHRASITRVIFHPIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGP--------------FLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVWDLRNKRCMKTLYAHQHFCTSIDFHKAHPYVISGSVDQTVKVWECR 411

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BLAST of lissencephaly-1 vs. Ensembl Fly
Match: wds (gene:FBgn0040066 transcript:FBtr0308566)

HSP 1 Score: 154.066 bits (388), Expect = 9.537e-42
Identity = 96/332 (28.92%), Postives = 161/332 (48.49%), Query Frame = 3

Query:  342 PRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFH----PQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVWE 1319
            P    +  L GH  +++ V+F P      S S D  IKIW    G +E+T+ GH   + D+A+    +LL S S D  +K+W+      +KTL GH + V   +F P  + ++S S D+++++W+V TG C++T   HSD V  V  N DGSLI S S D   R+W  A+ +C                          + L+DD       +       +  +G ++LA+ + D T++LWD + G CL    GH N  +  +F       GK+++S S+D  + IW+L+++   + L+ H   V     H     + + ++  D+ +K+W+
Sbjct:   60 PNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL-------------------------KTLIDDD------NPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLWK 358

HSP 2 Score: 143.28 bits (360), Expect = 8.938e-38
Identity = 95/283 (33.57%), Postives = 139/283 (49.12%), Query Frame = 3

Query:  489 TLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELV-FHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAH--DHFVTTIDFH-RNSPYVVTGSVDQIVKVWECR 1325
            TL GHT  V  + F P+G+ LAS SAD  IK+W   +    KT+SGH   +S V++      L+S S DKT+K+WE+STG  ++T +GHS++V     N   +LI S S D SVR+W +   +C      H   V         +H               N D S            L+ S S D   R+WDT +G CL  LI  +N     V F P GK++L+A+ D T+++WD    +C KT   H  + +    +F      ++V+GS D +V +W  +
Sbjct:   67 TLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSA-------VHF--------------NRDGS------------LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQ 316

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BLAST of lissencephaly-1 vs. Ensembl Zebrafish
Match: pafah1b1b (platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b [Source:NCBI gene;Acc:394247])

HSP 1 Score: 549.28 bits (1414), Expect = 0.000e+0
Identity = 257/427 (60.19%), Postives = 334/427 (78.22%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAK--ILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA+  +  E+DKKF+GLLEKKWTSVIRLQKKV +LES+L E K+E    I+     G+K    +W+PR P ++ L GHR+ +T V FHP++++ VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKT+K+WEV+TGYCV+TF GH +WVR+V+PN DG+L+ASCSND +VRVW +A KECK + REHEHVV+CI W  +  H   ++A            S NK  G    G  LL SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FHP G+F++S +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ SPYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDVNDELDKKFAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----ITLGGPVGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESAHPTISEAT----------GSENKKSG--KPGPFLL-SGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKTSPYVVTGSVDQTVKVWECR 410

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Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAK--ILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA+  +  E+DKKF+GLLEKKWTSVIRLQKKV +LES+L E K+E    I+     G+K    +W+PR P ++ L GHR+ +T V FHP++++ VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKT+K+WEV+TGYCV+TF GH +WVR+V+PN DG+L+ASCSND +VRVW +A KECK + REHEHVV+CI W  +  H   ++A            S NK  G    G  LL SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FHP G+F++S +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ SPYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDVNDELDKKFAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----ITLGGPVGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESAHPTISEAT----------GSENKKSG--KPGPFLL-SGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKTSPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. Ensembl Zebrafish
Match: pafah1b1a (platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a [Source:NCBI gene;Acc:394246])

HSP 1 Score: 535.798 bits (1379), Expect = 0.000e+0
Identity = 251/427 (58.78%), Postives = 329/427 (77.05%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    I+     G+K    +W+PR P ++ L GHR+ +T V FHP+++V VS SEDATIK+WD+E+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV+TGYCV+TF GH +WVR+V+PN DG+LIAS SND +VRVW +A KECK + REHEHVV+CI W  +  H    +A        S    S K   +       L SGSRD+TI++WD + G+CL  L+GH+NWV+ ++ HP GK+++S +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----INIGGPIGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVIVSASEDATIKVWDHETGDFERTLKGHTDSVQDISFDHTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLIASSSNDQTVRVWVVATKECKAELREHEHVVECISWAPESAHPTILEA------TGSETKKSGKPGPF-------LLSGSRDKTIKMWDVSIGMCLMTLVGHDNWVRGVLVHPGGKYIVSCADDKTLRIWDYKNKRCTKTLSAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

[Close]

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    I+     G+K    +W+PR P ++ L GHR+ +T V FHP+++V VS SEDATIK+WD+E+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV+TGYCV+TF GH +WVR+V+PN DG+LIAS SND +VRVW +A KECK + REHEHVV+CI W  +  H    +A        S    S K   +       L SGSRD+TI++WD + G+CL  L+GH+NWV+ ++ HP GK+++S +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----INIGGPIGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVIVSASEDATIKVWDHETGDFERTLKGHTDSVQDISFDHTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLIASSSNDQTVRVWVVATKECKAELREHEHVVECISWAPESAHPTILEA------TGSETKKSGKPGPF-------LLSGSRDKTIKMWDVSIGMCLMTLVGHDNWVRGVLVHPGGKYIVSCADDKTLRIWDYKNKRCTKTLSAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. Ensembl Zebrafish
Match: daw1 (dynein assembly factor with WDR repeat domains 1 [Source:NCBI gene;Acc:556760])

HSP 1 Score: 166.392 bits (420), Expect = 1.366e-45
Identity = 104/322 (32.30%), Postives = 152/322 (47.20%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFH-PLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQ--CIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            H L+GHR  +  + F+ P  +   +GS D T K+W  E+G    T RGHT  +  LAF+P   L+A+ S D   KLWD      V TL+GH   +  + F  +GD L++ S D T  LW+V +G  V    GH   +  V+ N+D SLIA+ S D S +VW     +C      H   V   C  + GQ                                   L+A+ S D T R++ T+T  CL  L GH   + ++ F+ QG  +L+AS DKT R+W +K   C + LE H   + +  F+     ++TGS D   ++W
Sbjct:  128 HTLEGHRNVVYAIAFNNPYGDKVATGSFDKTCKLWSAETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQ-----------------------------------LIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITGSKDNTCRIW 414

HSP 2 Score: 134.035 bits (336), Expect = 6.616e-34
Identity = 86/290 (29.66%), Postives = 144/290 (49.66%), Query Frame = 3

Query:  486 RTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSF-MPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREH--EHVVQCIVWGGQKIHMET--NQALLDDKQMTSNGDSSNKLDGYKMS--------GCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            R L+ H   + ++AF+ SG    + S D   K+WD      + TL GH + V  ++F  P GD + + S DKT KLW   TG C  TF GH+  +  +  N   +L+A+ S D + ++W + + E       H  E +  C    G ++   +  + A+L D     +G   + L G++           C L+A+ S D++ ++WD   G CL  L+GHN+ V ++ F+  G+ + +AS D T R++     +C   LE H   ++ + F+     V+T SVD+  +VW
Sbjct:   86 RALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNNPYGDKVATGSFDKTCKLWSAETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWD---VPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVW 372

HSP 3 Score: 100.523 bits (249), Expect = 2.351e-22
Identity = 66/258 (25.58%), Postives = 114/258 (44.19%), Query Frame = 3

Query:  549 LASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFD-GSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            L  C    ++   D  +F   + L  H   ++ V+F  SG   ++ S D+T K+W+ ++G  + T EGH + V  +  N   G  +A+ S D + ++WS    +C + FR H   + C+ +  Q                                   L+A+GS D T +LWD  +G  +  L GH   +  L F+  G  L++ S D T  +WD+ + R    L  H   ++ + F+ +   + T S+D+  KVW+
Sbjct:   65 LLICKLQEKVSQKDERKFYLFRALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNNPYGDKVATGSFDKTCKLWSAETGKCFYTFRGHTAEIVCLAFNPQST---------------------------------LVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWD 289

[Close]

BLAST of lissencephaly-1 vs. Ensembl Xenopus
Match: pafah1b1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1 [Source:NCBI gene;Acc:403097])

HSP 1 Score: 543.888 bits (1400), Expect = 0.000e+0
Identity = 256/427 (59.95%), Postives = 331/427 (77.52%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E     ++    G+K    +W+PR P ++ L GHR+ +T V FHP+++V V+ SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A KECK + REHEHVV+CI W       E++ + + D   +    S          G  LL SGSRD+TI++WD + G+CL  L+GH+NWV+ + FHP GKF+LS +DDKTIRIWD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----FTSGGPIGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVTASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP-----ESSYSTISDATGSETKKSGK-------PGPFLL-SGSRDKTIKMWDISIGMCLMTLVGHDNWVRGVQFHPGGKFILSCADDKTIRIWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

[Close]

BLAST of lissencephaly-1 vs. Ensembl Xenopus
Match: pafah1b1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1 [Source:NCBI gene;Acc:403097])

HSP 1 Score: 528.865 bits (1361), Expect = 0.000e+0
Identity = 253/430 (58.84%), Postives = 326/430 (75.81%), Query Frame = 3

Query:   54 VLSERQIEEL----NKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            V S RQ   L    N++IA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E     ++    G+K    +W+PR P ++ L GHR+ +T V FHP+++V V+ SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A KECK + REHEHVV+CI W       E++ + + D   +    S          G  LL SGSRD+TI++WD + G+CL  L+GH+NWV+ + FHP GKF+LS +DDKTIRIWD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    2 VFSHRQPIALEWLRNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----FTSGGPIGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVTASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP-----ESSYSTISDATGSETKKSGK-------PGPFLL-SGSRDKTIKMWDISIGMCLMTLVGHDNWVRGVQFHPGGKFILSCADDKTIRIWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 414

[Close]

BLAST of lissencephaly-1 vs. Ensembl Xenopus
Match: pafah1b1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1 [Source:NCBI gene;Acc:403097])

HSP 1 Score: 430.639 bits (1106), Expect = 7.419e-148
Identity = 206/386 (53.37%), Postives = 283/386 (73.32%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKM-SGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLK 1199
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E     ++    G+K    +W+PR P ++ L GHR+ +T V FHP+++V V+ SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A KECK + REHEHVV+CI W       E++ + + D   +  G   N + G +   G   + S + D+TIR+WD     C+  L  H ++V  L FH    ++++ S D+T+++W+ +
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----FTSGGPIGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVTASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP-----ESSYSTISDATGSEVG-HDNWVRGVQFHPGGKFILSCADDKTIRIWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 376

HSP 2 Score: 121.324 bits (303), Expect = 1.251e-29
Identity = 67/221 (30.32%), Postives = 106/221 (47.96%), Query Frame = 3

Query:  615 TLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPY 1277
             LSGH   V+ V F P    +++AS D TIK+W+  TG   +T +GH+D V+ +  +  G L+ASCS D ++++W     EC      H+H V  +                    +  NGD               + S SRD+TI++W+  TG C+    GH  WV+ +  +  G  + S S+D+T+R+W +  + C+  L  H+H V  I +   S Y
Sbjct:  103 ALSGHRSPVTRVIFHPVFSVMVTASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVA-------------------IMPNGDH--------------IVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSY 290

HSP 3 Score: 81.2629 bits (199), Expect = 4.734e-16
Identity = 37/101 (36.63%), Postives = 60/101 (59.41%), Query Frame = 3

Query: 1023 LLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            ++ + S D TI++WD  TG     L GH + VQ++ F   GK L S S D TI++WD +   C +T+  HDH V+++    N  ++V+ S D+ +K+WE +
Sbjct:  122 VMVTASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQ 222

HSP 4 Score: 73.559 bits (179), Expect = 1.781e-13
Identity = 36/98 (36.73%), Postives = 57/98 (58.16%), Query Frame = 3

Query: 1023 LLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            LLAS S D TI+LWD     C+  + GH++ V  +   P G  ++SAS DKTI++W+++   C KT   H  +V  +  +++   + + S DQ V+VW
Sbjct:  164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261

HSP 5 Score: 55.8398 bits (133), Expect = 1.009e-7
Identity = 24/77 (31.17%), Postives = 44/77 (57.14%), Query Frame = 3

Query: 1089 FNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            + L GH + V  ++FHP    +++AS+D TI++WD +    ++TL+ H   V  I F  +   + + S D  +K+W+
Sbjct:  102 YALSGHRSPVTRVIFHPVFSVMVTASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWD 178

[Close]

BLAST of lissencephaly-1 vs. Ensembl Xenopus
Match: daw1 (dynein assembly factor with WDR repeat domains 1 [Source:NCBI gene;Acc:394975])

HSP 1 Score: 167.162 bits (422), Expect = 1.457e-45
Identity = 99/320 (30.94%), Postives = 155/320 (48.44%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFH-PLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            H L+GHR  +  ++F+ P  +   +GS D T K+W  E+G    T RGHT  +  LAF+P   L+A+ S D   KLWD        TLSGH   +  +SF  +GD L++ S D T+ +WE+ +G    T  GH   +   + N+D SLIA+ S D S ++W   N +C      HE                       D+ +    DS+ +          L+A+ S D T R++  ++  CL  L GH   + ++ F+ QG  +L+AS DKT R+W+     C + L+ H   + +  F+     ++TGS D   ++W
Sbjct:  148 HTLEGHRNVVYAIQFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLAFNPQSTLIATGSMDTTAKLWDIQSGEEALTLSGHAAEIISLSFNTTGDRLITGSFDHTVSVWEIPSGRRNHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWDSLNGKCVATLTGHE-----------------------DEVLDVTFDSTGQ----------LVATASADGTARVYSASSRKCLAKLEGHEGEISKICFNAQGNRILTASSDKTSRLWNPHTGECLQVLKGHTDEIFSCAFNYEGNTIITGSKDNTCRIW 434

HSP 2 Score: 132.88 bits (333), Expect = 3.334e-33
Identity = 81/288 (28.12%), Postives = 142/288 (49.31%), Query Frame = 3

Query:  486 RTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSF-MPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWG--GQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMS--------GCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            + LR H   + ++AF+ SG    + S D   K+WD      + TL GH + V  + F  P GD + + S DKT KLW   TG C  TF GH+  +  +  N   +LIA+ S D + ++W + + E       H   +  + +   G ++   +    +   ++ S G  ++ L G++           C L+A+ S D++ +LWD+  G C+  L GH + V ++ F   G+ + +AS D T R++   +R+C   LE H+  ++ I F+     ++T S D+  ++W
Sbjct:  106 KVLRAHILPLTNVAFNKSGSSFITGSYDRTCKVWDTASGEELHTLEGHRNVVYAIQFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLAFNPQSTLIATGSMDTTAKLWDIQSGEEALTLSGHAAEIISLSFNTTGDRLITGSFDHTVSVWEIPS-GRRNHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWDSLNGKCVATLTGHEDEVLDVTFDSTGQLVATASADGTARVYSASSRKCLAKLEGHEGEISKICFNAQGNRILTASSDKTSRLW 392

HSP 3 Score: 120.168 bits (300), Expect = 8.100e-29
Identity = 58/167 (34.73%), Postives = 95/167 (56.89%), Query Frame = 3

Query:  339 LPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVW 839
            +P     H L GHR  I+  +F+   ++  + S D + K+WD  +G    TL GH + V D+ FD +G+L+A+ SAD   +++      C+  L GH+  +S + F   G+ +L+AS DKT +LW   TG C+Q  +GH+D +     N++G+ I + S DN+ R+W
Sbjct:  268 IPSGRRNHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWDSLNGKCVATLTGHEDEVLDVTFDSTGQLVATASADGTARVYSASSRKCLAKLEGHEGEISKICFNAQGNRILTASSDKTSRLWNPHTGECLQVLKGHTDEIFSCAFNYEGNTIITGSKDNTCRIW 434

HSP 4 Score: 103.219 bits (256), Expect = 4.502e-23
Identity = 66/250 (26.40%), Postives = 113/250 (45.20%), Query Frame = 3

Query:  573 QIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFD-GSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            +I   D  +F   K L  H   ++ V+F  SG   ++ S D+T K+W+ ++G  + T EGH + V  ++ N   G  IA+ S D + ++WS    +C   FR H   + C+ +  Q                                   L+A+GS D T +LWD  +G     L GH   +  L F+  G  L++ S D T+ +W++ + R   TL  H   +++  F+ +   + T S+D+  K+W+
Sbjct:   93 KIGQQDSRQFYLFKVLRAHILPLTNVAFNKSGSSFITGSYDRTCKVWDTASGEELHTLEGHRNVVYAIQFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLAFNPQST---------------------------------LIATGSMDTTAKLWDIQSGEEALTLSGHAAEIISLSFNTTGDRLITGSFDHTVSVWEIPSGRRNHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWD 309

[Close]

BLAST of lissencephaly-1 vs. Ensembl Xenopus
Match: daw1 (dynein assembly factor with WDR repeat domains 1 [Source:NCBI gene;Acc:394975])

HSP 1 Score: 167.162 bits (422), Expect = 1.533e-45
Identity = 99/320 (30.94%), Postives = 155/320 (48.44%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFH-PLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            H L+GHR  +  ++F+ P  +   +GS D T K+W  E+G    T RGHT  +  LAF+P   L+A+ S D   KLWD        TLSGH   +  +SF  +GD L++ S D T+ +WE+ +G    T  GH   +   + N+D SLIA+ S D S ++W   N +C      HE                       D+ +    DS+ +          L+A+ S D T R++  ++  CL  L GH   + ++ F+ QG  +L+AS DKT R+W+     C + L+ H   + +  F+     ++TGS D   ++W
Sbjct:  150 HTLEGHRNVVYAIQFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLAFNPQSTLIATGSMDTTAKLWDIQSGEEALTLSGHAAEIISLSFNTTGDRLITGSFDHTVSVWEIPSGRRNHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWDSLNGKCVATLTGHE-----------------------DEVLDVTFDSTGQ----------LVATASADGTARVYSASSRKCLAKLEGHEGEISKICFNAQGNRILTASSDKTSRLWNPHTGECLQVLKGHTDEIFSCAFNYEGNTIITGSKDNTCRIW 436

HSP 2 Score: 132.494 bits (332), Expect = 4.342e-33
Identity = 81/288 (28.12%), Postives = 142/288 (49.31%), Query Frame = 3

Query:  486 RTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSF-MPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWG--GQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMS--------GCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            + LR H   + ++AF+ SG    + S D   K+WD      + TL GH + V  + F  P GD + + S DKT KLW   TG C  TF GH+  +  +  N   +LIA+ S D + ++W + + E       H   +  + +   G ++   +    +   ++ S G  ++ L G++           C L+A+ S D++ +LWD+  G C+  L GH + V ++ F   G+ + +AS D T R++   +R+C   LE H+  ++ I F+     ++T S D+  ++W
Sbjct:  108 KVLRAHILPLTNVAFNKSGSSFITGSYDRTCKVWDTASGEELHTLEGHRNVVYAIQFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLAFNPQSTLIATGSMDTTAKLWDIQSGEEALTLSGHAAEIISLSFNTTGDRLITGSFDHTVSVWEIPS-GRRNHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWDSLNGKCVATLTGHEDEVLDVTFDSTGQLVATASADGTARVYSASSRKCLAKLEGHEGEISKICFNAQGNRILTASSDKTSRLW 394

HSP 3 Score: 120.168 bits (300), Expect = 7.843e-29
Identity = 58/167 (34.73%), Postives = 95/167 (56.89%), Query Frame = 3

Query:  339 LPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVW 839
            +P     H L GHR  I+  +F+   ++  + S D + K+WD  +G    TL GH + V D+ FD +G+L+A+ SAD   +++      C+  L GH+  +S + F   G+ +L+AS DKT +LW   TG C+Q  +GH+D +     N++G+ I + S DN+ R+W
Sbjct:  270 IPSGRRNHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWDSLNGKCVATLTGHEDEVLDVTFDSTGQLVATASADGTARVYSASSRKCLAKLEGHEGEISKICFNAQGNRILTASSDKTSRLWNPHTGECLQVLKGHTDEIFSCAFNYEGNTIITGSKDNTCRIW 436

HSP 4 Score: 103.219 bits (256), Expect = 4.938e-23
Identity = 66/250 (26.40%), Postives = 113/250 (45.20%), Query Frame = 3

Query:  573 QIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFD-GSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            +I   D  +F   K L  H   ++ V+F  SG   ++ S D+T K+W+ ++G  + T EGH + V  ++ N   G  IA+ S D + ++WS    +C   FR H   + C+ +  Q                                   L+A+GS D T +LWD  +G     L GH   +  L F+  G  L++ S D T+ +W++ + R   TL  H   +++  F+ +   + T S+D+  K+W+
Sbjct:   95 KIGQQDSRQFYLFKVLRAHILPLTNVAFNKSGSSFITGSYDRTCKVWDTASGEELHTLEGHRNVVYAIQFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLAFNPQST---------------------------------LIATGSMDTTAKLWDIQSGEEALTLSGHAAEIISLSFNTTGDRLITGSFDHTVSVWEIPSGRRNHTLIGHRGEISSAQFNWDCSLIATASMDKSCKLWD 311

[Close]

BLAST of lissencephaly-1 vs. Ensembl Mouse
Match: Pafah1b1 (platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 [Source:MGI Symbol;Acc:MGI:109520])

HSP 1 Score: 543.888 bits (1400), Expect = 0.000e+0
Identity = 251/427 (58.78%), Postives = 330/427 (77.28%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E     ++    G+K    +W+PR P ++ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A KECK + REHEHVV+CI W  +  +   ++A   + + +                   L SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FH  GKF+LS +DDKT+R+WD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----FTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGP-------------FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

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Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E     ++    G+K    +W+PR P ++ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A KECK + REHEHVV+CI W  +  +   ++A   + + +                   L SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FH  GKF+LS +DDKT+R+WD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----FTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGP-------------FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. Ensembl Mouse
Match: Wdr5 (WD repeat domain 5 [Source:MGI Symbol;Acc:MGI:2155884])

HSP 1 Score: 162.155 bits (409), Expect = 6.972e-45
Identity = 104/361 (28.81%), Postives = 170/361 (47.09%), Query Frame = 3

Query:  261 QETKKETHDVISNAT--FKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFH----PQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVWE 1319
            +E K ET    +  T      +S      P    +  L GH  +++ V+F P      S S D  IKIW    G +E+T+ GH   + D+A+     LL S S D  +K+WD     C+KTL GH + V   +F P  + ++S S D+++++W+V TG C++T   HSD V  V  N DGSLI S S D   R+W  A+ +C                          + L+DD     +         +  +G ++LA+ + D T++LWD + G CL    GH N  +  +F       GK+++S S+D  + IW+L+ +   + L+ H   V +   H     + + ++  D+ +K+W+
Sbjct:    4 EEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL-------------------------KTLIDDDNPPVS------FVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331

HSP 2 Score: 150.599 bits (379), Expect = 1.288e-40
Identity = 97/287 (33.80%), Postives = 144/287 (50.17%), Query Frame = 3

Query:  489 TLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELV-FHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAH--DHFVTTIDFH-RNSPYVVTGSVDQIVKVWECR*SQI 1337
            TL GHT  V  + F P+G+ LAS SAD  IK+W   +    KT+SGH   +S V++    + L+SAS DKT+K+W+VS+G C++T +GHS++V     N   +LI S S D SVR+W +   +C      H   V         +H               N D S            L+ S S D   R+WDT +G CL  LI  +N     V F P GK++L+A+ D T+++WD    +C KT   H  + +    +F      ++V+GS D +V +W  +  +I
Sbjct:   40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA-------VHF--------------NRDGS------------LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293

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BLAST of lissencephaly-1 vs. Ensembl Mouse
Match: Daw1 (dynein assembly factor with WDR repeat domains 1 [Source:MGI Symbol;Acc:MGI:1923089])

HSP 1 Score: 162.54 bits (410), Expect = 2.882e-44
Identity = 100/320 (31.25%), Postives = 155/320 (48.44%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFH-PLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            H L+GH+  +  + F+ P  +   +GS D T K+W  E+G    T RGHT  +  L+F+P   ++A+ S D   KLWD      V TL+GH   +  +SF  SGD +++ S D T+ +W+ STG  V T  GH   +     N+D SLI + S D +  +W   + +       H                       DD+ + S  D + KL          +A+ S D T R+++  T  C+  L GH   + ++ F+PQG  LL+ S DKT RIWD++  +C + LE H   + +  F+     V+TGS D   ++W
Sbjct:  128 HTLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGH-----------------------DDEILDSCFDYTGKL----------IATASADGTARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNSCRIW 414

HSP 2 Score: 92.0485 bits (227), Expect = 1.433e-19
Identity = 61/241 (25.31%), Postives = 105/241 (43.57%), Query Frame = 3

Query:  600 FTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFD-GSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            F   K L  H   ++ V+   +G   ++ S D+T K+W+ ++G  + T EGH + V  +  N   G  IA+ S D + ++WS    +C   FR H   + C+ +  Q                                   ++A+GS D T +LWD   G  +  L GH   +  L F   G  +++ S D T+ +WD    R   TL  H   +++  F+ +   ++TGS+D+   +W+
Sbjct:   82 FYLFKVLRAHILPLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQST---------------------------------VVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWD 289

HSP 3 Score: 74.7146 bits (182), Expect = 7.568e-14
Identity = 69/281 (24.56%), Postives = 110/281 (39.15%), Query Frame = 3

Query:  522 LAFDPSGKLLA-SCSADMQIKLWDFVEF---TCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTG-----------YCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            L + P G +L      +++ K  D +E    T V TL G          +   + L++ASR K ++L                 Y  +    H   +  V  N  GS   + S D + +VW  A+ E       H++VV  I +                     N    +K+           A+GS D+T +LW   TG C     GH   +  L F+PQ   + + S D T ++WD++N     TL  H   + ++ F  +   ++TGS D  V VW+
Sbjct:    8 LRYYPPGIMLEYEKGGELKTKSIDLLELSPSTDVNTLVGE---------IQQAEPLITASRTKQVRLLVQRLQEKLRQHSDHNFYLFKVLRAHILPLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAF---------------------NNPYGDKI-----------ATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWD 247

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BLAST of lissencephaly-1 vs. Ensembl Mouse
Match: Wdr5b (WD repeat domain 5B [Source:MGI Symbol;Acc:MGI:1916794])

HSP 1 Score: 156.377 bits (394), Expect = 7.619e-43
Identity = 97/330 (29.39%), Postives = 155/330 (46.97%), Query Frame = 3

Query:  342 PRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNN--WVQELVFHPQG-KFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVW 1316
            P    R  L GH A+I+ V+F P      S + DA I IW    G+ ++TL GH+  + D+A+      L S S D  +K+WD     C+KTL GH   V    F P  + ++S S D+++K+WEV TG C++T   HSD +  V  N +GSLI S S D   R+W  A+ +C                                + +   G+       +  +G ++L + + D T++LWD + G CL    GH N  +     F   G K+++S S+D  + IW+L+ +   + L+ H   V +   H     + + ++  D+ +KVW
Sbjct:   27 PNYALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCL-------------------------------RTLADEGNPPVSFVKFSPNGKYIL-TATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLFASFSVTGRKWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAACHPTKNIIASAALENDKTIKVW 324

HSP 2 Score: 144.05 bits (362), Expect = 3.151e-38
Identity = 90/287 (31.36%), Postives = 136/287 (47.39%), Query Frame = 3

Query:  489 TLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELV-FHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAH--DHFVTTIDFH-RNSPYVVTGSVDQIVKVWECR*SQI 1337
            TL GH+  +  + F P+G+ LAS +AD  I +W   +  C KTL GH   +S V++      L+SAS DKT+K+W++ +G C++T +GHSD+V     N   +LI S S D SV++W +   +C      H   +  +                       NG               L+ SGS D   R+WD  +G CL  L    N     V F P GK++L+A+ D T+++WD    RC KT   H  + +     F      +VV+GS D +V +W  +  +I
Sbjct:   34 TLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGNCKKTLYGHSLEISDVAWSSDSSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKCLKTLSAHSDPISAV-------------------NFNCNGS--------------LIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLFASFSVTGRKWVVSGSEDNMVYIWNLQTKEI 287

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BLAST of lissencephaly-1 vs. UniProt/SwissProt
Match: sp|C3XVT5|LIS1_BRAFL (Lissencephaly-1 homolog OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_59218 PE=3 SV=1)

HSP 1 Score: 552.362 bits (1422), Expect = 0.000e+0
Identity = 262/425 (61.65%), Postives = 329/425 (77.41%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ EELNK+IA+YL  NGY+     F+ EA++ GEI+KK++GLLEKKWTSVIRLQKKV DLE++L E +KE     S    K  +S S +W+PR PAR+ L GHR+ IT V FHP+Y+V VS SEDATIKIWDYE+GD+ERTL+GHT+ VQD++FD  GKLLASCSADM IKLWDF  F  +KT+ GHDHNVS V FMP+GD L+SASRDKTIK+WE++TGYCV+TF GH +WVR V+ N DGSL+ASCSND +VRVW +ANKECK + REHEHVV+CI W  +  +   ++ +  +K+  S                  L SGSRD+TI++WD +TGVC+  L+GH+NWV+ +V+HP GK+++SASDDKTIR+WD KN+RCQKTLEAH HF T+IDFHR++PYV+TGSVDQ VKVWECR
Sbjct:    1 MVLSQRQREELNKAIADYLRSNGYESALEAFQKEAEMPGEIEKKYTGLLEKKWTSVIRLQKKVMDLEAKLAEAEKEFQ---SGGPNKKERSPS-EWIPRPPARYSLSGHRSPITRVLFHPVYSVMVSASEDATIKIWDYETGDFERTLKGHTDAVQDVSFDQQGKLLASCSADMTIKLWDFQTFENIKTMHGHDHNVSSVHFMPNGDFLISASRDKTIKMWELATGYCVKTFTGHREWVRTVRVNQDGSLLASCSNDQTVRVWVVANKECKAELREHEHVVECIAWAPESCNGHVSEVMGAEKKGRSGP---------------FLLSGSRDKTIKMWDISTGVCIMTLVGHDNWVRGVVWHPGGKYIISASDDKTIRVWDYKNKRCQKTLEAHQHFCTSIDFHRSAPYVITGSVDQTVKVWECR 406

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BLAST of lissencephaly-1 vs. UniProt/SwissProt
Match: sp|Q803D2|LIS1B_DANRE (Lissencephaly-1 homolog B OS=Danio rerio OX=7955 GN=pafah1b1b PE=2 SV=3)

HSP 1 Score: 548.51 bits (1412), Expect = 0.000e+0
Identity = 257/427 (60.19%), Postives = 334/427 (78.22%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAK--ILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA+  +  E+DKKF+GLLEKKWTSVIRLQKKV +LES+L E K+E    I+     G+K    +W+PR P ++ L GHR+ +T V FHP++++ VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKT+K+WEV+TGYCV+TF GH +WVR+V+PN DG+L+ASCSND +VRVW +A KECK + REHEHVV+CI W  +  H   ++A            S NK  G    G  LL SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FHP G+F++S +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ SPYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDVNDELDKKFAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----ITLGGPVGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESAHPTISEAT----------GSENKKSG--KPGPFLL-SGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. UniProt/SwissProt
Match: sp|Q4RJN5|LIS1_TETNG (Lissencephaly-1 homolog OS=Tetraodon nigroviridis OX=99883 GN=pafah1b1 PE=3 SV=1)

HSP 1 Score: 545.814 bits (1405), Expect = 0.000e+0
Identity = 255/427 (59.72%), Postives = 333/427 (77.99%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILG--EIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    I+      +K    +W+PR P R+ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKT+K+WEV+TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A+KECK + REHEHVV+CI W  +  H      +LD    +S    S K   +       L SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FHP GKF+++ +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDNNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----ITLGGPVSQKRDPKEWIPRPPERYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDLTGKLLASCSADMTIKLWDFQSFECIRTMHGHDHNVSSVAIMPNGDHIISASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKECKAELREHEHVVECISWAPESAH----PTILD--ATSSESKKSGKPGPF-------LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHPGGKFIVTCADDKTLRIWDYKNKRCMKTLCAHEHFVTSLDFHKAAPYVVTGSVDQTVKVWECR 410

[Close]

BLAST of lissencephaly-1 vs. UniProt/SwissProt
Match: sp|P43034|LIS1_HUMAN (Platelet-activating factor acetylhydrolase IB subunit alpha OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2)

HSP 1 Score: 544.658 bits (1402), Expect = 0.000e+0
Identity = 251/427 (58.78%), Postives = 330/427 (77.28%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAK--ILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA+  +  E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E     ++    G+K    +W+PR P ++ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A KECK + REHEHVV+CI W  +  +   ++A   + + +                   L SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FH  GKF+LS +DDKT+R+WD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----FTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGP-------------FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. UniProt/SwissProt
Match: sp|Q6NZH4|LIS1_XENTR (Lissencephaly-1 homolog OS=Xenopus tropicalis OX=8364 GN=pafah1b1 PE=2 SV=3)

HSP 1 Score: 543.888 bits (1400), Expect = 0.000e+0
Identity = 256/427 (59.95%), Postives = 331/427 (77.52%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E     ++    G+K    +W+PR P ++ L GHR+ +T V FHP+++V V+ SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A KECK + REHEHVV+CI W       E++ + + D   +    S          G  LL SGSRD+TI++WD + G+CL  L+GH+NWV+ + FHP GKF+LS +DDKTIRIWD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----FTSGGPIGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVTASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP-----ESSYSTISDATGSETKKSGK-------PGPFLL-SGSRDKTIKMWDISIGMCLMTLVGHDNWVRGVQFHPGGKFILSCADDKTIRIWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. TrEMBL
Match: I0E0N1 (Lissencephaly-1 homolog OS=Schmidtea mediterranea OX=79327 GN=lis1 PE=2 SV=1)

HSP 1 Score: 883.248 bits (2281), Expect = 0.000e+0
Identity = 425/425 (100.00%), Postives = 425/425 (100.00%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR
Sbjct:    1 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 425

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BLAST of lissencephaly-1 vs. TrEMBL
Match: A0A4S2MH89 (Lissencephaly-1 homolog OS=Opisthorchis felineus OX=147828 GN=CRM22_001415 PE=3 SV=1)

HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0
Identity = 267/456 (58.55%), Postives = 337/456 (73.90%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSS------------VDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCH-------------------LLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVL++RQ EELN++I +YL  NGY      FK EA I GE+D+KFSGLLEKKWTSVIRLQKKV DLE++L E ++E   V + A +    ++             VD +PR PAR  L GHR+ IT V FHP YNVFVS SEDATIK+WDYESG++E TL+GHT+ VQD+AFDPSGKLLASCSADMQ+KLWDF  + CVKTL+GHDHNVS V+F+PSGD L+SASRDKTIK+WEV++GYCV+TF GH++W+R V+P+ +G+L+ASCSND ++R+WS+  +EC+   R HEHVV+CI W     H  + QA+ +    T+   SS  +D    +  H                    LASGSRDR+IR+WD NTG+CLF LIGH+NWV++LVFHPQG+ LLSASDDKT+R+WDLKNRRCQKTLEAH HFVTT+D +R +P V+TGSVDQ V++W+CR
Sbjct:    1 MVLAQRQKEELNRAIVDYLSSNGYHNALNAFKEEASIEGEMDRKFSGLLEKKWTSVIRLQKKVLDLEAKLLEAEREMQSVQAAAGYGPPGAAPGSGLTGRGDRRGVDAIPRPPARFTLTGHRSPITRVAFHPHYNVFVSASEDATIKVWDYESGEFEHTLKGHTDSVQDVAFDPSGKLLASCSADMQVKLWDFTLYQCVKTLAGHDHNVSSVAFLPSGDFLVSASRDKTIKMWEVASGYCVKTFSGHAEWIRAVRPSPEGNLLASCSNDQTIRIWSVETRECQMVLRGHEHVVECIAW---VTHPNSVQAITNPNAPTA---SSQNVDNINATVIHNGPSATGDTVPLPASTSTVFLASGSRDRSIRMWDVNTGMCLFELIGHDNWVRQLVFHPQGRLLLSASDDKTVRVWDLKNRRCQKTLEAHSHFVTTLDVNRIAPVVITGSVDQTVRIWDCR 450

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BLAST of lissencephaly-1 vs. TrEMBL
Match: A0A3P8P0Z6 (Lissencephaly-1 homolog OS=Astatotilapia calliptera OX=8154 GN=PAFAH1B1 PE=3 SV=1)

HSP 1 Score: 553.132 bits (1424), Expect = 0.000e+0
Identity = 260/427 (60.89%), Postives = 333/427 (77.99%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    +++    G+K    +W+PR P R+ L GHRA +T V FHP+++V V+ SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV+TGYCV+TF GH +WVR+V+PN DGSLIASCSND +VRVW +A+KECK + REHEHVV+CI W     H    +A            S NK  G    G  LL SGSRD+TI++WD + G+CL  L+GH+NWV+ ++FHP G+F++S +DDKTIRIWD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDMNEEVDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----MTHGGSVGQKRDPKEWIPRPPERYALSGHRAPVTRVIFHPVFSVMVTASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQSGKLLASCSADMSIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVVASKECKAELREHEHVVECIAWAPDSAHPTILEAT----------GSENKKSG--KPGPFLL-SGSRDKTIKMWDVSIGICLMTLVGHDNWVRGILFHPGGRFIVSCADDKTIRIWDYKNKRCMKTLSAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. TrEMBL
Match: A0A3P9DHN1 (Lissencephaly-1 homolog OS=Maylandia zebra OX=106582 GN=PAFAH1B1 PE=3 SV=1)

HSP 1 Score: 553.132 bits (1424), Expect = 0.000e+0
Identity = 260/427 (60.89%), Postives = 333/427 (77.99%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    +++    G+K    +W+PR P R+ L GHRA +T V FHP+++V V+ SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV+TGYCV+TF GH +WVR+V+PN DGSLIASCSND +VRVW +A+KECK + REHEHVV+CI W     H    +A            S NK  G    G  LL SGSRD+TI++WD + G+CL  L+GH+NWV+ ++FHP G+F++S +DDKTIRIWD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDMNEEVDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----MTHGGSVGQKRDPKEWIPRPPERYALSGHRAPVTRVIFHPVFSVMVTASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQSGKLLASCSADMSIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVVASKECKAELREHEHVVECIAWAPDSAHPTILEAT----------GSENKKSG--KPGPFLL-SGSRDKTIKMWDVSIGICLMTLVGHDNWVRGILFHPGGRFIVSCADDKTIRIWDYKNKRCMKTLSAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. TrEMBL
Match: A0A3B4GNF4 (Lissencephaly-1 homolog OS=Pundamilia nyererei OX=303518 GN=PAFAH1B1 PE=3 SV=1)

HSP 1 Score: 553.132 bits (1424), Expect = 0.000e+0
Identity = 260/427 (60.89%), Postives = 333/427 (77.99%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    +++    G+K    +W+PR P R+ L GHRA +T V FHP+++V V+ SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV+TGYCV+TF GH +WVR+V+PN DGSLIASCSND +VRVW +A+KECK + REHEHVV+CI W     H    +A            S NK  G    G  LL SGSRD+TI++WD + G+CL  L+GH+NWV+ ++FHP G+F++S +DDKTIRIWD KN+RC KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDMNEEVDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----MTHGGSVGQKRDPKEWIPRPPERYALSGHRAPVTRVIFHPVFSVMVTASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQSGKLLASCSADMSIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVVASKECKAELREHEHVVECIAWAPDSAHPTILEAT----------GSENKKSG--KPGPFLL-SGSRDKTIKMWDVSIGICLMTLVGHDNWVRGILFHPGGRFIVSCADDKTIRIWDYKNKRCMKTLSAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. Ensembl Cavefish
Match: pafah1b1b (lissencephaly-1 homolog B [Source:NCBI gene;Acc:103047044])

HSP 1 Score: 551.206 bits (1419), Expect = 0.000e+0
Identity = 260/427 (60.89%), Postives = 333/427 (77.99%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA+I    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    I+     G+K    +W+PR P ++ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV+TGYCV+TF GH +WVR+V+PN DG+L+ASCSND +VRVW  A KECK + REHEHVV+CI W  +  H    +A            S NK  G    G  LL SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FHP GKF++S +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ SPYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAEIDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----ITLGGPVGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVAATKECKAELREHEHVVECISWAPESAHPTILEAT----------GSENKKSG--KPGPFLL-SGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHPGGKFIVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKTSPYVVTGSVDQTVKVWECR 410

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BLAST of lissencephaly-1 vs. Ensembl Cavefish
Match: pafah1b1a (lissencephaly-1 homolog A-like [Source:NCBI gene;Acc:103030333])

HSP 1 Score: 545.814 bits (1405), Expect = 0.000e+0
Identity = 255/427 (59.72%), Postives = 334/427 (78.22%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E ++E    I+      +K    +W+PR P R+ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKT+K+WEV+TGYC +TF GH +WVR+V+PN DGSLIASCSND +VRVW +A KECK + REHEHVV+CI W  +  H    Q ++D     + G  + K       G  LL SGSRD+TI++WD + G+CL  L+GH+NWV+ ++FHP GKF++S +DDKT+RIWD KN+RC+KTL AH+HFVT++DFH+ +PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAQEE----ITLGGPIAQKRDPKEWIPRPPERYSLSGHRSPVTKVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIISASRDKTMKMWEVATGYCTKTFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESAH----QTIMD-----ATGSETKK---SGKPGPFLL-SGSRDKTIKMWDVSIGMCLMTLVGHDNWVRGMMFHPGGKFIISCADDKTLRIWDYKNKRCKKTLSAHEHFVTSLDFHKAAPYVVTGSVDQTVKVWECR 410

[Close]

BLAST of lissencephaly-1 vs. Ensembl Cavefish
Match: pafah1b1a (lissencephaly-1 homolog A-like [Source:NCBI gene;Acc:103030333])

HSP 1 Score: 483.026 bits (1242), Expect = 2.002e-168
Identity = 226/390 (57.95%), Postives = 298/390 (76.41%), Query Frame = 3

Query:   90 SIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTI 1253
            SIA+YL  NGY+E Y++FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E ++E    I+      +K    +W+PR P R+ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKT+K+WEV+TGYC +TF GH +WVR+V+PN DGSLIASCSND +VRVW +A KECK + REHEHVV+CI W  +  H    Q ++D     S    S K   +       L SGSRD+TI++WD + G+CL  L+GH+NWV+ ++FHP GKF++S +DDKT+RIWD KN+RC+KTL AH+HFVT++
Sbjct:   18 SIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAQEE----ITLGGPIAQKRDPKEWIPRPPERYSLSGHRSPVTKVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIISASRDKTMKMWEVATGYCTKTFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESAH----QTIMD--ATGSETKKSGKPGPF-------LLSGSRDKTIKMWDVSIGMCLMTLVGHDNWVRGMMFHPGGKFIISCADDKTLRIWDYKNKRCKKTLSAHEHFVTSL 390

HSP 2 Score: 81.2629 bits (199), Expect = 3.270e-16
Identity = 37/99 (37.37%), Postives = 59/99 (59.60%), Query Frame = 3

Query: 1023 LLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            ++ S S D TI++WD  TG     L GH + VQ++ F   GK L S S D TI++WD +   C +T+  HDH V+++    N  ++++ S D+ +K+WE
Sbjct:  126 VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIISASRDKTMKMWE 224

HSP 3 Score: 72.7886 bits (177), Expect = 2.152e-13
Identity = 35/98 (35.71%), Postives = 56/98 (57.14%), Query Frame = 3

Query: 1023 LLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            LLAS S D TI+LWD     C+  + GH++ V  +   P G  ++SAS DKT+++W++    C KT   H  +V  +  +++   + + S DQ V+VW
Sbjct:  168 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIISASRDKTMKMWEVATGYCTKTFTGHREWVRMVRPNQDGSLIASCSNDQTVRVW 265

HSP 4 Score: 58.5362 bits (140), Expect = 8.113e-9
Identity = 25/77 (32.47%), Postives = 46/77 (59.74%), Query Frame = 3

Query: 1089 FNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            ++L GH + V +++FHP    ++SAS+D TI++WD +    ++TL+ H   V  I F +    + + S D  +K+W+
Sbjct:  106 YSLSGHRSPVTKVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWD 182

[Close]

BLAST of lissencephaly-1 vs. Ensembl Cavefish
Match: pafah1b1b (lissencephaly-1 homolog B [Source:NCBI gene;Acc:103047044])

HSP 1 Score: 379.793 bits (974), Expect = 4.051e-128
Identity = 206/445 (46.29%), Postives = 268/445 (60.22%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI--LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVS------------------TGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y++FK EA+I    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    I+     G+K    +W+PR P ++ L G                                          H + V  + F P   ++ S S D  IK+WD+      +TL GH  +V  +SF  +G  L S S D TIKLW+                      YCV+TF GH +WVR+V+PN DG+L+ASCSND +VRVW  A KECK + REHEHVV+CI W  +  H    +A            S NK  G    G  LL SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FHP GKF++S +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ SPYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAEIDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----ITLGGPVGQKRDPKEWIPRPPEKYALSG------------------------------------------HRSPVTRVIFHPVFSVMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHVYRFTFFFHLLYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVAATKECKAELREHEHVVECISWAPESAHPTILEAT----------GSENKKSG--KPGPFLL-SGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHPGGKFIVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKTSPYVVTGSVDQTVKVWECR 386

[Close]

BLAST of lissencephaly-1 vs. Ensembl Cavefish
Match: wdr5 (WD repeat domain 5 [Source:NCBI gene;Acc:103033424])

HSP 1 Score: 162.54 bits (410), Expect = 4.323e-45
Identity = 98/332 (29.52%), Postives = 161/332 (48.49%), Query Frame = 3

Query:  342 PRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFH----PQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVWE 1319
            P    +  L GH  +++ V+F P      S S D  IKIW    G +E+T+ GH   + D+A+     LL S S D  +K+WD     C+KTL GH + V   +F P  + ++S S D+++++W+V TG C++T   HSD V  V  N DGSLI S S D   R+W  A+ +C                          + L+DD       +       +  +G ++LA+ + D T++LWD + G CL    GH N  +  +F       GK+++S S+D  + IW+L+ +   + L+ H   V +   H     + + ++  D+ +K+W+
Sbjct:   33 PNYTLKFTLAGHTKAVSSVKFSPSGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL-------------------------KTLIDDD------NPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331

HSP 2 Score: 151.754 bits (382), Expect = 4.393e-41
Identity = 98/287 (34.15%), Postives = 144/287 (50.17%), Query Frame = 3

Query:  489 TLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELV-FHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAH--DHFVTTIDFH-RNSPYVVTGSVDQIVKVWECR*SQI 1337
            TL GHT  V  + F PSG+ LAS SAD  IK+W   +    KT+SGH   +S V++    + L+SAS DKT+K+W+VS+G C++T +GHS++V     N   +LI S S D SVR+W +   +C      H   V         +H               N D S            L+ S S D   R+WDT +G CL  LI  +N     V F P GK++L+A+ D T+++WD    +C KT   H  + +    +F      ++V+GS D +V +W  +  +I
Sbjct:   40 TLAGHTKAVSSVKFSPSGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA-------VHF--------------NRDGS------------LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQTKEI 293

HSP 3 Score: 131.724 bits (330), Expect = 7.594e-34
Identity = 85/299 (28.43%), Postives = 143/299 (47.83%), Query Frame = 3

Query:  321 SSSVDWLPRIPARH------VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTF-EGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSAS--DDKTIRIW 1190
            SSS D L +I   +       + GH+  I+ V +    N+ VS S+D T+KIWD  SG   +TL+GH+N+V    F+P   L+ S S D  +++WD     C+KTL  H   VS V F   G  ++S+S D   ++W+ ++G C++T  +  +  V  VK + +G  I + + DN++++W  +  +C   +  H++   CI                                 + ++G   + SGS D  + +W+  T   +  L GH + V     HP    + SA+  +DKTI++W
Sbjct:   62 SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI------------------------------FANFSVTGGKWIVSGSEDNMVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330

[Close]

BLAST of lissencephaly-1 vs. Ensembl Sea Lamprey
Match: pafah1b1b (platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b [Source:NCBI gene;Acc:394247])

HSP 1 Score: 461.455 bits (1186), Expect = 2.291e-161
Identity = 213/364 (58.52%), Postives = 282/364 (77.47%), Query Frame = 3

Query:  234 KVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            +V +LES+L E K+E   V       G++    +W+PR P ++ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD SGK+LASCSADM +KLWDF  F C++T+ GHDHNVS V+FMP+GDHL+SASRDKT+K+WEV TGYCV+TF GH +WVR+V+PN DGSLIASCSND +VRVW  A KECK + REHEHVV+C+ W         +  +L+     + G  + K  G K  G +LL SGSRD+TI++WD +TG+C+  L+GH+NWV+ ++FHP GKF+LS +DDKT+R+WD KN+RCQK+L AH+HFVT++DFH+ +PYV+TGSVDQ VKVWECR
Sbjct:    1 QVMELESKLNEAKEEF--VSGGGPLGGQRRDPSEWIPRPPEKYALSGHRSPVTRVIFHPVFSVIVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDLSGKMLASCSADMTVKLWDFQSFECLRTMHGHDHNVSSVAFMPNGDHLVSASRDKTMKMWEVQTGYCVKTFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVTATKECKAELREHEHVVECVSWAPDA----ASPVILE-----ATGAEAKK--GGK-PGPYLL-SGSRDKTIKMWDISTGICVITLVGHDNWVRGVLFHPGGKFILSCADDKTLRVWDYKNKRCQKSLAAHEHFVTSLDFHKTAPYVITGSVDQSVKVWECR 349

[Close]

BLAST of lissencephaly-1 vs. Ensembl Sea Lamprey
Match: POC1A (POC1 centriolar protein A [Source:HGNC Symbol;Acc:HGNC:24488])

HSP 1 Score: 166.007 bits (419), Expect = 8.356e-46
Identity = 103/321 (32.09%), Postives = 148/321 (46.11%), Query Frame = 3

Query:  357 RHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            RH  KGHR +IT V F+P      SGS DA + +W+++         GH + V  + F PSG L+ S S D  ++LW             H   V  VSF   G  L++AS DK+IK+W V     + +   HS+WVR  K + DG LI S S+D +VRVW   ++EC   F EH                               G   N++D +    C  +A+   D T+++WD      L +   H   V  L FHP G +L++AS+D T+++ DL   R   TL  H    T + F R   +  +G  D+ V VW+
Sbjct:   12 RH-FKGHRDTITSVDFNPNMKQLASGSMDACLMVWNFKPQTRAYRFVGHKDAVMSVQFSPSGHLVVSASRDKTVRLWVPSVKGESTVFKAHTATVRSVSFSADGQSLVTASDDKSIKVWTVHRQKFLYSLNQHSNWVRSAKFSPDGRLIVSGSDDRTVRVWDSNSRECVHTFYEH-------------------------------GGFVNQVDFHPSGTC--IAAAGTDNTVKVWDIRMNKLLQHYQVHGAAVNSLSFHPTGNYLITASNDSTLKVLDLVEGRLFYTLHGHQGPATAVAFSRAGDFFASGGSDEQVMVWK 298

HSP 2 Score: 144.436 bits (363), Expect = 4.717e-38
Identity = 82/284 (28.87%), Postives = 139/284 (48.94%), Query Frame = 3

Query:  468 ESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            E    ER  +GH + +  + F+P+ K LAS S D  + +W+F   T      GH   V  V F PSG  ++SASRDKT++LW  S       F+ H+  VR V  + DG  + + S+D S++VW++  ++  +   +H + V+                     + + +G               L+ SGS DRT+R+WD+N+  C+     H  +V ++ FHP G  + +A  D T+++WD++  +  +  + H   V ++ FH    Y++T S D  +KV +
Sbjct:    6 EDPSLERHFKGHRDTITSVDFNPNMKQLASGSMDACLMVWNFKPQTRAYRFVGHKDAVMSVQFSPSGHLVVSASRDKTVRLWVPSVKGESTVFKAHTATVRSVSFSADGQSLVTASDDKSIKVWTVHRQKFLYSLNQHSNWVR-------------------SAKFSPDG--------------RLIVSGSDDRTVRVWDSNSRECVHTFYEHGGFVNQVDFHPSGTCIAAAGTDNTVKVWDIRMNKLLQHYQVHGAAVNSLSFHPTGNYLITASNDSTLKVLD 256

HSP 3 Score: 115.161 bits (287), Expect = 7.349e-28
Identity = 67/234 (28.63%), Postives = 105/234 (44.87%), Query Frame = 3

Query:  624 GHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            GH   ++ V F P+   L S S D  + +W          F GH D V  V+ +  G L+ S S D +VR+W  + K     F+ H   V+ +                     +++G S              L + S D++I++W  +    L++L  H+NWV+   F P G+ ++S SDD+T+R+WD  +R C  T   H  FV  +DFH +   +     D  VKVW+ R
Sbjct:   16 GHRDTITSVDFNPNMKQLASGSMDACLMVWNFKPQTRAYRFVGHKDAVMSVQFSPSGHLVVSASRDKTVRLWVPSVKGESTVFKAHTATVRSV-------------------SFSADGQS--------------LVTASDDKSIKVWTVHRQKFLYSLNQHSNWVRSAKFSPDGRLIVSGSDDRTVRVWDSNSRECVHTFYEHGGFVNQVDFHPSGTCIAAAGTDNTVKVWDIR 216

HSP 4 Score: 93.5893 bits (231), Expect = 9.879e-21
Identity = 51/192 (26.56%), Postives = 92/192 (47.92%), Query Frame = 3

Query:  336 WLPRIPARH-VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVW 908
            W+P +     V K H A++  V F       V+ S+D +IK+W      +  +L  H+N V+   F P G+L+ S S D  +++WD     CV T   H   V+ V F PSG  + +A  D T+K+W++     +Q ++ H   V  +  +  G+ + + SND++++V  +      +    H+     + +
Sbjct:   87 WVPSVKGESTVFKAHTATVRSVSFSADGQSLVTASDDKSIKVWTVHRQKFLYSLNQHSNWVRSAKFSPDGRLIVSGSDDRTVRVWDSNSRECVHTFYEHGGFVNQVDFHPSGTCIAAAGTDNTVKVWDIRMNKLLQHYQVHGAAVNSLSFHPTGNYLITASNDSTLKVLDLVEGRLFYTLHGHQGPATAVAF 278

[Close]

BLAST of lissencephaly-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008862.1 (pep scaffold:Pmarinus_7.0:GL476579:86637:114999:1 gene:ENSPMAG00000008000.1 transcript:ENSPMAT00000008862.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 157.147 bits (396), Expect = 5.713e-42
Identity = 108/330 (32.73%), Postives = 161/330 (48.79%), Query Frame = 3

Query:  348 IPARHVLKGHRAS-ITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEA---HDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            I A  VLKGH    ITC++F    N  VSGS+D T+K+W   +G   RTL GHT  V        G ++ S S D  +K+W+     CV TL GH   V  +     G+ ++S SRD T+++W++ TG C+    GH   VR V+  +DG  + S + D +V+VW   ++ C    + H                                  +N++   +  G H++ SGS D +IR+WD  TG CL  L+GH +    +    +   L+S + D T++IWD+K  +C +TL+    H   VT + F R    VVT S D  VK+W+ R
Sbjct:  223 IRAPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RGNIIVSGSTDRTLKVWNADTGQCVHTLYGHTSTVRCMHL--HGNRVVSGSRDATLRVWDIETGQCLHVLAGHVAAVRCVQ--YDGRRVVSGAYDYTVKVWDPESETCLHTLQGH----------------------------------TNRVYSLQFDGVHIV-SGSLDTSIRVWDAETGTCLHTLVGHQSLTSGMEL--RDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFSRK--LVVTSSDDGTVKLWDLR 505

HSP 2 Score: 124.405 bits (311), Expect = 1.045e-30
Identity = 84/284 (29.58%), Postives = 132/284 (46.48%), Query Frame = 3

Query:  486 RTLRGHTNHVQD-LAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR*SQ 1334
            + L+GH +HV   L F   G  + S S D  +K+W  V   C++TL GH   V   S    G+ ++S S D+T+K+W   TG CV T  GH+  VR +  +  G+ + S S D ++RVW +   +C      H   V+C+ + G+++                                    SG+ D T+++WD  +  CL  L GH N V  L F   G  ++S S D +IR+WD +   C  TL  H    + ++   N   +V+G+ D  VK+W+ +  Q
Sbjct:  227 KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV--WSSQMRGNIIVSGSTDRTLKVWNADTGQCVHTLYGHTSTVRCM--HLHGNRVVSGSRDATLRVWDIETGQCLHVLAGHVAAVRCVQYDGRRV-----------------------------------VSGAYDYTVKVWDPESETCLHTLQGHTNRVYSLQF--DGVHIVSGSLDTSIRVWDAETGTCLHTLVGHQSLTSGMELRDN--ILVSGNADSTVKIWDIKTGQ 465

HSP 3 Score: 119.398 bits (298), Expect = 5.881e-29
Identity = 81/265 (30.57%), Postives = 126/265 (47.55%), Query Frame = 3

Query:  417 NVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIG---HNNWVQELVFHPQGKFLLSASDDKTIRIWDLKN 1202
            N+ VSGS D T+K+W+ ++G    TL GHT+ V+ +     G  + S S D  +++WD     C+  L+GH   V  V +   G  ++S + D T+K+W+  +  C+ T +GH++  RV    FDG  I S S D S+RVW      C      H                   Q+L    ++  N                +L SG+ D T+++WD  TG CL  L G   H + V  L F    K ++++SDD T+++WDL+ 
Sbjct:  285 NIIVSGSTDRTLKVWNADTGQCVHTLYGHTSTVRCMHLH--GNRVVSGSRDATLRVWDIETGQCLHVLAGHVAAVRCVQY--DGRRVVSGAYDYTVKVWDPESETCLHTLQGHTN--RVYSLQFDGVHIVSGSLDTSIRVWDAETGTCLHTLVGH-------------------QSLTSGMELRDN----------------ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF--SRKLVVTSSDDGTVKLWDLRT 506

HSP 4 Score: 51.9878 bits (123), Expect = 2.425e-7
Identity = 35/99 (35.35%), Postives = 53/99 (53.54%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRG---HTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSG 647
            H L GH++  + +      N+ VSG+ D+T+KIWD ++G   +TL+G   H + V  L F  S KL+ + S D  +KLWD      ++ L   D   SG
Sbjct:  428 HTLVGHQSLTSGMELRD--NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF--SRKLVVTSSDDGTVKLWDLRTGDFLRNLVSLDSGGSG 522

[Close]

BLAST of lissencephaly-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004902.1 (pep scaffold:Pmarinus_7.0:GL478254:5937:33805:1 gene:ENSPMAG00000004437.1 transcript:ENSPMAT00000004902.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 147.517 bits (371), Expect = 2.478e-38
Identity = 94/320 (29.38%), Postives = 143/320 (44.69%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
              LK H   ++ +  HP   + V+ S+D   K+W   +GD   T +GHT+ + D  F+P+G  LA+   D  +K+WDF +  CV TL GH H V G S+   GD + S+S D + K+W+V++  C QT  GH+D V  V+     S + + S D ++ +W      C   F  H H                N    + K     GD+    D Y +              I++WD   G     L    +    L FHP G  +  ASDD  +RI DL     + TL  H+  V  + F  +   + +G  D  +++WE
Sbjct:  329 QTLKAHEMPVSSMALHPRKEIIVTASDDQLWKMWSIPNGDIIMTGQGHTDWIGDCDFNPTGTNLATGGGDSTVKVWDFSQGACVLTLEGHGHAVWGCSWHSCGDFIASSSMDNSSKVWDVNSERCRQTLRGHTDSVNSVEFLPYSSTLLTSSADKTLSLWDARTGRCAQIFYGHLH--------------SCNHGTFNLK-----GDTVVSCDSYGV--------------IKVWDVRKGTATMTLNLGPHPANRLSFHPSGHVMAVASDDACVRIVDLLTGHVE-TLSGHEDAVQAVVFSPDGDTLFSGGSDGTIRMWE 614

HSP 2 Score: 104.76 bits (260), Expect = 4.490e-24
Identity = 65/238 (27.31%), Postives = 105/238 (44.12%), Query Frame = 3

Query:  612 KTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            +TL  H+  VS ++  P  + +++AS D+  K+W +  G  + T +GH+DW+     N  G+ +A+   D++V+VW  +   C      H H V    W                    S GD               +AS S D + ++WD N+  C   L GH + V  + F P    LL++S DKT+ +WD +  RC +    H H      F+     VV+     ++KVW+ R
Sbjct:  329 QTLKAHEMPVSSMALHPRKEIIVTASDDQLWKMWSIPNGDIIMTGQGHTDWIGDCDFNPTGTNLATGGGDSTVKVWDFSQGACVLTLEGHGHAVWGCSW-------------------HSCGD--------------FIASSSMDNSSKVWDVNSERCRQTLRGHTDSVNSVEFLPYSSTLLTSSADKTLSLWDARTGRCAQIFYGHLHSCNHGTFNLKGDTVVSCDSYGVIKVWDVR 533

HSP 3 Score: 93.5893 bits (231), Expect = 2.099e-20
Identity = 51/161 (31.68%), Postives = 84/161 (52.17%), Query Frame = 3

Query:  357 RHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVW 839
            R  L+GH  S+  V F P  +  ++ S D T+ +WD  +G   +   GH +      F+  G  + SC +   IK+WD  + T   TL+   H  + +SF PSG  +  AS D  +++ ++ TG+ V+T  GH D V+ V  + DG  + S  +D ++R+W
Sbjct:  454 RQTLRGHTDSVNSVEFLPYSSTLLTSSADKTLSLWDARTGRCAQIFYGHLHSCNHGTFNLKGDTVVSCDSYGVIKVWDVRKGTATMTLNLGPHPANRLSFHPSGHVMAVASDDACVRIVDLLTGH-VETLSGHEDAVQAVVFSPDGDTLFSGGSDGTIRMW 613

[Close]

BLAST of lissencephaly-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002506.1 (pep scaffold:Pmarinus_7.0:GL479076:26529:32136:-1 gene:ENSPMAG00000002224.1 transcript:ENSPMAT00000002506.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 124.02 bits (310), Expect = 6.894e-32
Identity = 97/344 (28.20%), Postives = 156/344 (45.35%), Query Frame = 3

Query:  345 RIPARHVLKGHRASITCVRFHPLY-NVFVSGSEDATIKIW-----DYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFE--GHSDWVRVVK--PNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTL---------EAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            ++  R  LKGH   +T +   P + ++ +S S D T+ +W     +   G  +R+L GH + V D+     G+   S S D  ++LWD    T  +   GH  +V  V+F      ++S SRDKTIKLW  + G C  T +  GH++WV  V+  PN +  +I SC  D  V+VW++ N  CK    +  H+       G   ++ T         +T + D S            L ASG +D    LWD N G  L+ L G +  +  L F P  ++ L A+   +I+IWDL+ +     L         +A      ++ +  +   +  G  D  ++VW+
Sbjct:    4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTLIMWKLTRDETNYGIPQRSLHGHGHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWN-TLGVCKYTIQEDGHTEWVSCVRFSPNNNNPIIVSCGWDKLVKVWNLTN--CKL---KTNHI-------GHTGYLNT---------VTVSPDGS------------LCASGGKDGQAMLWDLNEGKHLYTLDGGDT-INALCFSPN-RYWLCAATGPSIKIWDLEGKVIVDELRQEVISTSSKAEPPQCISLAWSADGQTLFAGYTDNFIRVWQ 311

HSP 2 Score: 66.2402 bits (160), Expect = 3.392e-12
Identity = 49/170 (28.82%), Postives = 77/170 (45.29%), Query Frame = 3

Query:  372 GHRASITCVRFHPLYN--VFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTF--EGHSDWVRVVKP-------NFDGSLIASCSNDNSVRVWSMA 848
            GH   ++CVRF P  N  + VS   D  +K+W+  +   +    GHT ++  +   P G L AS   D Q  LWD  E   + TL G D  ++ + F P+  + L A+   +IK+W++     V     E  S   +   P       + DG  + +   DN +RVW + 
Sbjct:  146 GHTEWVSCVRFSPNNNNPIIVSCGWDKLVKVWNLTNCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-TINALCFSPN-RYWLCAATGPSIKIWDLEGKVIVDELRQEVISTSSKAEPPQCISLAWSADGQTLFAGYTDNFIRVWQVT 313

[Close]

BLAST of lissencephaly-1 vs. Ensembl Yeast
Match: RSA4 (WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus [Source:SGD;Acc:S000000668])

HSP 1 Score: 135.576 bits (340), Expect = 8.487e-35
Identity = 122/454 (26.87%), Postives = 205/454 (45.15%), Query Frame = 3

Query:   54 VLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQL-QETKKETHDVIS-----NATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHP-LYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCV-KTLSGHDHNVSGVSFMP-------SGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANK-ECKFDFREHEHVVQCIVWGGQKIHMETNQAL-------LDDKQMTSNGDSSNKLDGY----KMSGC--HLLASGSRDRTIRLWDT-NTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
             +SE+Q+EEL   +      NG  +    +     I G           KK +  ++     ++L S L +     T D I+      A FK +        P   +   + GH ++I C  F P   +  V+G+ D T +IWD ++     TL+GH N V  +++ P G+++A+ S D  I+LWD     C+   L GH   ++ +S+ P       S   L S+S+D TIK+W+  +  C  T  GH++ V  VK    G L+ S S+D +VRVW + ++  C    + H H V         + + T+ AL          K  T        L+ Y    K +G    ++ + S D T+ LW+   +   +  + GH   V  + F P G++++SAS D +I++WD ++ +   T   H   V  + +  +   +V+ S D  +KVW+ R
Sbjct:   54 AISEKQLEELLNQL------NGTSDDPVPYTFSCTIQG-----------KKASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVK--------PVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVN-------HLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVR 474

HSP 2 Score: 135.191 bits (339), Expect = 1.080e-34
Identity = 99/349 (28.37%), Postives = 160/349 (45.85%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGD-YERTLRGHTNHVQDLAFDP-------SGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEV-STGYCVQTFEGHSDWVRVVKPNFDGSL----------IASCSNDNSVRVWSMANKECKFDFREHEHVVQC------IVWGGQK-----IHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            H LKGH   + CV + P   V  +GS D TI++WD +SG      LRGH+  +  L+++P       S   LAS S D  IK+WD V   C  T+SGH ++VS V +   G  L S S D+T+++W++ S G C+   + H+ WV  +  + D +L            S   +   +      K CK +    E +V         +W   K       M  +Q L++    + +G                + S S D +I+LWD   G  +    GH   V ++ +    + L+S S D T+++WD++ R+    L  H   V T+D+  +   V +G  D++V++W
Sbjct:  180 HTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDG--------------RYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513

HSP 3 Score: 86.6557 bits (213), Expect = 1.498e-18
Identity = 62/225 (27.56%), Postives = 104/225 (46.22%), Query Frame = 3

Query:  357 RHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYES-GDYERTLRGHTNHVQDL-----------AFDPSGK----------------------------LLASCSADMQIKLWDFVEFT-CVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVW 908
            ++ + GH  S++CV++     +  SGS D T+++WD  S G     L+ H + V  L           AFD +GK                            ++ + S D  + LW+ ++ T  +  ++GH   V+ V+F P G +++SAS D +IKLW+   G  + TF GH   V  V  + D  L+ SCS D +++VW +  ++   D   H+  V  + W
Sbjct:  271 QYTMSGHTNSVSCVKWGG-QGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDW 494

HSP 4 Score: 76.2554 bits (186), Expect = 2.986e-15
Identity = 47/142 (33.10%), Postives = 72/142 (50.70%), Query Frame = 3

Query:  420 VFVSGSEDATIKIWD-YESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWS 842
            + V+ S+D T+ +W+  +S      + GH   V  +AF P G+ + S S D  IKLWD  +   + T  GH  +V  V++      L+S S+D T+K+W+V T        GH D V  V  + DG  + S   D  VR+W+
Sbjct:  373 MMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLWT 514

[Close]

BLAST of lissencephaly-1 vs. Ensembl Yeast
Match: MET30 (F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p [Source:SGD;Acc:S000001308])

HSP 1 Score: 136.732 bits (343), Expect = 9.973e-35
Identity = 96/303 (31.68%), Postives = 146/303 (48.18%), Query Frame = 3

Query:  366 LKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQK-------IHMETNQALLDDKQMTSNGDSSNK--------LDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEA 1229
             KGH   +  ++F+  Y +  +GS D+TI IWD  +G   R L GH++ V+ L FD   + L + S D  I++W+++   C+ T  GH  +V  V        ++S S DKT+K+W V +  C  T  GH++WV  VK +       SCS+D ++R+W +    C   FR H   VQ I+    K        +     +  DD  MT   D S+         LD       HLL+ G  D TI+LWD  TG C+    GH   V ++        ++S S D +I++WDL++ +C  T   
Sbjct:  298 FKGHMDGVLTLQFN--YRLLFTGSYDSTIGIWDLFTGKLIRRLSGHSDGVKTLYFD--DRKLITGSLDKTIRVWNYITGECISTYRGHSDSVLSVDSYQKV--IVSGSADKTVKVWHVESRTCY-TLRGHTEWVNCVKLHPKSFSCFSCSDDTTIRMWDIRTNSCLKVFRGHVGQVQKIIPLTIKDVENLATDNTSDGSSPQDDPTMTDGADESDTPSNEQETVLDENIPYPTHLLSCG-LDNTIKLWDVKTGKCIRTQFGHVEGVWDIA--ADNFRIISGSHDGSIKVWDLQSGKCMHTFNG 590

HSP 2 Score: 88.9669 bits (219), Expect = 3.867e-19
Identity = 54/186 (29.03%), Postives = 83/186 (44.62%), Query Frame = 3

Query:  675 LLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAH 1232
            L + S D TI +W++ TG  ++   GHSD V+ +   FD   + + S D ++RVW+    EC   +R H                                DS   +D Y+     ++ SGS D+T+++W   +  C + L GH  WV  +  HP+     S SDD TIR+WD++   C K    H
Sbjct:  315 LFTGSYDSTIGIWDLFTGKLIRRLSGHSDGVKTLY--FDDRKLITGSLDKTIRVWNYITGECISTYRGH-------------------------------SDSVLSVDSYQ----KVIVSGSADKTVKVWHVESRTC-YTLRGHTEWVNCVKLHPKSFSCFSCSDDTTIRMWDIRTNSCLKVFRGH 462

HSP 3 Score: 76.2554 bits (186), Expect = 4.357e-15
Identity = 58/195 (29.74%), Postives = 86/195 (44.10%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQ-----------DLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWV-RVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDF------REHEHV 890
            + L+GH   + CV+ HP      S S+D TI++WD  +    +  RGH   VQ           +LA D +    +           D  +    +  +  D N+      P   HLLS   D TIKLW+V TG C++T  GH + V  +   NF    I S S+D S++VW + + +C   F      RE +H 
Sbjct:  415 YTLRGHTEWVNCVKLHPKSFSCFSCSDDTTIRMWDIRTNSCLKVFRGHVGQVQKIIPLTIKDVENLATDNTSDGSSPQDDPTMTDGADESDTPSNEQETVLDENI------PYPTHLLSCGLDNTIKLWDVKTGKCIRTQFGHVEGVWDIAADNF---RIISGSHDGSIKVWDLQSGKCMHTFNGRRLQRETQHT 600

HSP 4 Score: 65.855 bits (159), Expect = 8.627e-12
Identity = 38/98 (38.78%), Postives = 56/98 (57.14%), Query Frame = 3

Query: 1023 LLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            LL +GS D TI +WD  TG  +  L GH++ V+ L F    + L++ S DKTIR+W+     C  T   H   V ++D ++    +V+GS D+ VKVW
Sbjct:  314 LLFTGSYDSTIGIWDLFTGKLIRRLSGHSDGVKTLYF--DDRKLITGSLDKTIRVWNYITGECISTYRGHSDSVLSVDSYQK--VIVSGSADKTVKVW 407

[Close]

BLAST of lissencephaly-1 vs. Ensembl Yeast
Match: PAC1 (Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly [Source:SGD;Acc:S000005795])

HSP 1 Score: 134.035 bits (336), Expect = 1.744e-34
Identity = 138/501 (27.54%), Postives = 234/501 (46.71%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKET-------------YAIFKGEAKILGE-IDKKF----------------SGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISN----ATFKGRKSSS------VDWLPR-IPARHVLKGHRASITCVRFHP-LYNVFVSGSEDATIKIWDYESGDYE---RTLRGHTNHV--QDLAF----DPSGK---LLASCSADMQIKLWDFVEFTC----VKTLSGHDHNVSGVSFMPSGD--HLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGV-----------------CLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEA-HDHFVTT----IDFHRN-SP--YVVTGSVD 1298
            + L++ Q  EL+KS+  YL  N YK+T             +AI      +L E +D++                   LL KKW S++RLQKK+ +LE   +    +  D+ +     A FK   S+       + W+PR +P+   L    +S+T V+ HP L  VFV+       K++ ++  +Y     +L+ HT  +   D+ F    + S K   ++ + S D+QI ++ +V   C    +++L GH+H VS V      +  H+ S SRD+T+K+W+   G+ ++TF+ HS WVR +  +  G  I S S+D ++R+    +         HE  ++ +    + IH      + D  ++     S+++   + M  C    S SRDRTI++W+                      C+  L GH +WV+++    +G++L S +DDK++R WDL   +C    E  H  FV      +DF  N +P   +VTG +D
Sbjct:    8 LPLTDTQKNELDKSVLRYLNWN-YKQTVRHEHAQDYESVRHAIVTLSGFLLQESVDRQEFISNNDTSNESMVDIDELLLPKKWNSIVRLQKKIIELEQNTETLVSQIKDLNTQVSELAQFKPTTSNGTSAHNVLKWIPRNLPS--CLINVESSVTSVKLHPNLPIVFVATDHG---KLYAFDLFNYTIPLASLQSHTKAITSMDVLFTNYTNSSKKNYLVIVTASKDLQIHVFKWVSEECKFQQIRSLLGHEHIVSAVKIWQKNNDVHIASCSRDQTVKIWDFHNGWSLKTFQPHSQWVRSI--DVLGDYIISGSHDTTLRLTHWPSGNGLSVGTGHEFPIEKV----KFIHF-----IEDSPEIRFRTPSTDRYKNWGMQYC---VSASRDRTIKIWEIPLPTLMAHRAPIPNPTDSNFRCVLTLKGHLSWVRDISI--RGQYLFSCADDKSVRCWDLNTGQCLHVWEKLHTGFVNCLDLDVDFDSNVTPRQMMVTGGLD 486

[Close]

BLAST of lissencephaly-1 vs. Ensembl Yeast
Match: TUP1 (General repressor of transcription; forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes [Source:SGD;Acc:S000000680])

HSP 1 Score: 112.079 bits (279), Expect = 1.372e-26
Identity = 75/290 (25.86%), Postives = 124/290 (42.76%), Query Frame = 3

Query:  510 HVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWD------------TNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPY------VVTGSVDQIVKVWECR 1325
            +++ + F P GK LA+ + D  I++WD      V  L GH+ ++  + + PSGD L+S S D+T+++W++ TG C  T         V     DG  IA+ S D +VRVW   + E  F                           LD +  +  G   +            + SGS DR+++LW+             N+G C    IGH ++V  +      +++LS S D+ +  WD K+      L+ H + V ++     SP         TGS D   ++W+ +
Sbjct:  445 YIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMILQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPGDGKYIAAGSLDRAVRVW---DSETGFLVER-----------------------LDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWDKKSGNPLLMLQGHRNSVISVAVANGSPLGPEYNVFATGSGDCKARIWKYK 708

HSP 2 Score: 107.457 bits (267), Expect = 5.440e-25
Identity = 80/285 (28.07%), Postives = 122/285 (42.81%), Query Frame = 3

Query:  387 ITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPS-GDHLLSASRDKTIKLWEVSTGYCVQTFE-------GHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELV------FHPQGKFLLSASDDKTIRIWDLK 1199
            I  V F P      +G+ED  I+IWD E+      L+GH   +  L + PSG  L S S D  +++WD     C  TLS  D  V+ V+  P  G ++ + S D+ +++W+  TG+ V+  +       GH D V  V    DG  + S S D SV++W++ N   K D +        + + G K  + +     +D+                      + SGS+DR +  WD  +G  L  L GH N V  +         P+     + S D   RIW  K
Sbjct:  446 IRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMILQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIED-GVTTVAVSPGDGKYIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDE---------------------YILSGSKDRGVLFWDKKSGNPLLMLQGHRNSVISVAVANGSPLGPEYNVFATGSGDCKARIWKYK 708

HSP 3 Score: 88.5817 bits (218), Expect = 5.407e-19
Identity = 62/261 (23.75%), Postives = 107/261 (41.00%), Query Frame = 3

Query:  594 VEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNL-------IGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRR------------CQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            VE     +    D  +  V F P G  L + + D+ I++W++     V   +GH   +  +     G  + S S D +VR+W +   +C       + V    V  G                           DG        +A+GS DR +R+WD+ TG  +  L        GH + V  +VF   G+ ++S S D+++++W+L+N              C+ T   H  FV ++   +N  Y+++GS D+ V  W+
Sbjct:  431 VENLNTSSSPSSDLYIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMILQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPG---------------------------DG------KYIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWD 658

HSP 4 Score: 80.4925 bits (197), Expect = 2.014e-16
Identity = 61/213 (28.64%), Postives = 95/213 (44.60%), Query Frame = 3

Query:  363 VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPS-GKLLASCSADMQIKLWDFVEFTCVKTL-------SGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEV------------STGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEH-VVQCIVWGGQKIHMETN 938
            +L+GH   I  + + P  +  VSGS D T++IWD  +G    TL    + V  +A  P  GK +A+ S D  +++WD      V+ L       +GH  +V  V F   G  ++S S D+++KLW +            ++G C  T+ GH D+V  V    +   I S S D  V  W   +       + H + V+   V  G  +  E N
Sbjct:  480 ILQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIE-DGVTTVAVSPGDGKYIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWDKKSGNPLLMLQGHRNSVISVAVANGSPLGPEYN 691

HSP 5 Score: 66.2402 bits (160), Expect = 6.789e-12
Identity = 25/74 (33.78%), Postives = 49/74 (66.22%), Query Frame = 3

Query: 1113 WVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR*SQ 1334
            +++ + F P GKFL + ++D+ IRIWD++NR+    L+ H+  + ++D+  +   +V+GS D+ V++W+ R  Q
Sbjct:  445 YIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMILQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQ 518

[Close]

BLAST of lissencephaly-1 vs. Ensembl Yeast
Match: COP1 (Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway [Source:SGD;Acc:S000002304])

HSP 1 Score: 109.768 bits (273), Expect = 1.287e-25
Identity = 82/286 (28.67%), Postives = 124/286 (43.36%), Query Frame = 3

Query:  396 VRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNK--LDGYKM--------SGCHLLASGSRDRTIRLWDTNTGVC--LFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQK 1217
            + FHP     +     +TI++WDY  G        H   V+ L F P+  +  S   D  IK+W      C+ TL+GH   V  V F      ++SAS D+TI++W       +    GH+ +V   + +    LI S S D ++R+W ++        R+         +  Q   M   Q LLD     S GD   K  L+G+              L+ SGS DR ++LW  +      +    GH N V  ++FHP    ++S  +DKT+R+WDL  R   K
Sbjct:   17 IAFHPSRPWVLVALFSSTIQLWDYRMGTLLHRFEDHEGPVRGLDFHPTQPIFVSAGDDYTIKVWSLDTNKCLYTLTGHLDYVRTVFFHRELPWIISASDDQTIRIWNWQNRKEIACLTGHNHFVMCAQFHPTDDLIVSASLDETIRIWDISG------LRKRHSAPGTSSFEEQ---MSAQQNLLDG----SLGDCVVKFILEGHTRGVNWASFHPTLPLIVSGSDDRQVKLWRMSATKAWEVDTCRGHTNNVDSVIFHPHQNLIISVGEDKTLRVWDLDKRTPVK 289

HSP 2 Score: 92.8189 bits (229), Expect = 3.912e-20
Identity = 87/360 (24.17%), Postives = 145/360 (40.28%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEV----------------------------STGYCVQTF--EGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSM-ANKECKFDF-REHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDL-KNRRCQKTLEAHDHFVT------TIDFHRNSPYVVTGSVDQIVKVWEC 1322
            H  + H   +  + FHP   +FVS  +D TIK+W  ++     TL GH ++V+ + F      + S S D  I++W++     +  L+GH+H V    F P+ D ++SAS D+TI++W++                            S G CV  F  EGH+  V     +    LI S S+D  V++W M A K  + D  R H + V  +++     H   N                            L+ S   D+T+R+WD +    +      N+    +  HP    L  A+ D  I ++ L + R C    +    FV       + +F +    +   S+  I + W+ 
Sbjct:   47 HRFEDHEGPVRGLDFHPTQPIFVSAGDDYTIKVWSLDTNKCLYTLTGHLDYVRTVFFHRELPWIISASDDQTIRIWNWQNRKEIACLTGHNHFVMCAQFHPTDDLIVSASLDETIRIWDISGLRKRHSAPGTSSFEEQMSAQQNLLDGSLGDCVVKFILEGHTRGVNWASFHPTLPLIVSGSDDRQVKLWRMSATKAWEVDTCRGHTNNVDSVIF-----HPHQN----------------------------LIISVGEDKTLRVWDLDKRTPVKQFKRENDRFWLIAAHPHIN-LFGAAHDSGIMVFKLDRERPCSFIHQNQLFFVNAEKQIQSFNFQKRVASLPYASLKGIGQPWDA 372

HSP 3 Score: 85.5001 bits (210), Expect = 6.472e-18
Identity = 66/254 (25.98%), Postives = 101/254 (39.76%), Query Frame = 3

Query:  645 GVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRR------------------------------CQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            G++F PS   +L A    TI+LW+   G  +  FE H   VR +  +    +  S  +D +++VWS+   +C +    H   V+ + +     H E                               + S S D+TIR+W+      +  L GHN++V    FHP    ++SAS D+TIRIWD+   R                               +  LE H   V    FH   P +V+GS D+ VK+W
Sbjct:   16 GIAFHPSRPWVLVALFSSTIQLWDYRMGTLLHRFEDHEGPVRGLDFHPTQPIFVSAGDDYTIKVWSLDTNKCLYTLTGHLDYVRTVFF-----HRE----------------------------LPWIISASDDQTIRIWNWQNRKEIACLTGHNHFVMCAQFHPTDDLIVSASLDETIRIWDISGLRKRHSAPGTSSFEEQMSAQQNLLDGSLGDCVVKFILEGHTRGVNWASFHPTLPLIVSGSDDRQVKLW 236

HSP 4 Score: 58.9214 bits (141), Expect = 1.496e-9
Identity = 30/88 (34.09%), Postives = 46/88 (52.27%), Query Frame = 3

Query:  357 RHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDY--ERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVK 614
            + +L+GH   +    FHP   + VSGS+D  +K+W   +       T RGHTN+V  + F P   L+ S   D  +++WD  + T VK
Sbjct:  202 KFILEGHTRGVNWASFHPTLPLIVSGSDDRQVKLWRMSATKAWEVDTCRGHTNNVDSVIFHPHQNLIISVGEDKTLRVWDLDKRTPVK 289

[Close]

BLAST of lissencephaly-1 vs. Ensembl Nematostella
Match: EDO41896 (Lissencephaly-1 homolog [Source:UniProtKB/Swiss-Prot;Acc:A7S338])

HSP 1 Score: 533.102 bits (1372), Expect = 0.000e+0
Identity = 247/425 (58.12%), Postives = 325/425 (76.47%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVL+ RQ EELNK+IA+YL   G+++T   FK +A + GE+DKK++GLLEKKWTSVIRLQKKV DLE++L E +KE H    +     +  S  DW+PR P R+ L GHR+ IT V FHP+Y+V V+ SEDAT+K+WDYE+GD+ERTL+GHT+ VQDLAFD +GK LAS SADM IKLWDF  F C++TL GHDHNVS +SF+PSGDHL+SASRDKTIK+WE++TGYCV+TF+GH +WVR V+PN DGSLIASCSND ++RVW +A++ECK D R+H+HV++ + W       E+   ++++      G  +       MS    L S SRD++I++WD + GVCL  L+GH+NWV+ ++FHP GKF++S SDDKT+RIWD KN+RC KTL AH+HFVTT+DFH+++P+V TGSVD  +KVWECR
Sbjct:    1 MVLTPRQKEELNKAIADYLHQCGFEDTLNAFKQDANMPGELDKKYTGLLEKKWTSVIRLQKKVMDLETRLSEAEKEVH----HGGGPKKTRSPEDWIPRPPERYTLTGHRSPITKVLFHPVYSVMVTSSEDATVKVWDYETGDFERTLKGHTDAVQDLAFDHTGKFLASSSADMTIKLWDFQGFECIRTLHGHDHNVSSISFLPSGDHLVSASRDKTIKMWEIATGYCVKTFQGHGEWVRRVRPNADGSLIASCSNDQTIRVWVVASRECKCDLRDHDHVIEDLNWAP-----ESATPVINEAAGVEGGKKA-------MSPGPFLVSASRDKSIKIWDVSAGVCLVTLVGHDNWVRAVMFHPGGKFIVSCSDDKTLRIWDYKNKRCAKTLVAHEHFVTTLDFHKSAPFVATGSVDLTLKVWECR 409

[Close]

BLAST of lissencephaly-1 vs. Ensembl Nematostella
Match: EDO33297 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SSL6])

HSP 1 Score: 160.999 bits (406), Expect = 9.280e-45
Identity = 98/332 (29.52%), Postives = 163/332 (49.10%), Query Frame = 3

Query:  342 PRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFH----PQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVWE 1319
            P    ++ L GH  +++ V+F        S S D  IKIW    G +E+T+ GH   + D+A+    + L S S D  +K+WDF    C+KTL GH + V   +F P  + ++S S D+++++W+V TG C++T   HSD V  V  N DG+LI S S D   R+W  A+ +C                          + L+DD     +         +  +G ++LA+ + D T++LWD + G CL    GH N  +  VF       GK+++S S+D  + IW+L+++   + L+ H   V     H     + +G++  D+ +K+W+
Sbjct:   53 PNYQLKYTLTGHNKAVSSVKFSHNGEWLASSSADKVIKIWGAYDGKFEKTITGHKLGISDVAWSTDSRHLVSASDDKTLKIWDFATGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVTAVHFNRDGALIVSSSYDGLCRIWDTASGQCL-------------------------KTLIDDDNPPVS------FVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKN-EKYCVFANFSVTGGKWIVSGSEDHKVYIWNLQSKEVVQKLDGHSDVVLCCACHPTENIIASGALENDKTIKIWK 351

HSP 2 Score: 122.094 bits (305), Expect = 1.238e-30
Identity = 85/329 (25.84%), Postives = 151/329 (45.90%), Query Frame = 3

Query:  255 QLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLK--------------GHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTF-EGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSAS--DDKTIRIW 1190
            QL+ T    +  +S+  F    S + +WL    A  V+K              GH+  I+ V +       VS S+D T+KIWD+ +G   +TL+GH+N+V    F+P   L+ S S D  +++WD     C+KTL  H   V+ V F   G  ++S+S D   ++W+ ++G C++T  +  +  V  VK + +G  I + + DN++++W  +  +C   +  H++   C+                                 + ++G   + SGS D  + +W+  +   +  L GH++ V     HP    + S +  +DKTI+IW
Sbjct:   56 QLKYTLTGHNKAVSSVKF----SHNGEWLASSSADKVIKIWGAYDGKFEKTITGHKLGISDVAWSTDSRHLVSASDDKTLKIWDFATGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVTAVHFNRDGALIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCV------------------------------FANFSVTGGKWIVSGSEDHKVYIWNLQSKEVVQKLDGHSDVVLCCACHPTENIIASGALENDKTIKIW 350

[Close]

BLAST of lissencephaly-1 vs. Ensembl Nematostella
Match: EDO45346 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTA6])

HSP 1 Score: 162.54 bits (410), Expect = 1.386e-44
Identity = 99/322 (30.75%), Postives = 149/322 (46.27%), Query Frame = 3

Query:  357 RHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWEC 1322
            RH  KGHR ++T V F+P     V+GS D+++ IW ++         GH + +  + F PSG L+AS S D  ++LW             H   V  V F   G  LL+AS DK++K+W V     + +   H +WVR  K + DG LI S S+D ++++W   +K+C   F +                                G   N ++ +    C  +A+G  D T+++WD      L +   H   V  + FHP G +L+SAS D T++I DL   R   TL  H    T++ F RN  Y  +GS D+ V VW+ 
Sbjct:   12 RH-FKGHRDTVTSVDFNPNMKQLVTGSMDSSLMIWHFKPHMRAYRFVGHKDAILSVKFSPSGHLIASASRDKTVRLWVPSVKGESTVFKAHTATVRSVDFSGDGQSLLTASDDKSLKVWTVHRQKFLYSLNAHMNWVRCAKFSPDGRLIVSGSDDKTIKLWDRTSKDCVHTFYD-------------------------------PGGFVNSVEFHPSGTC--IAAGGTDSTVKVWDIRMNKLLQHYQAHTGAVNSVSFHPSGNYLVSASSDTTLKILDLMEGRLFYTLHGHQGPATSVVFSRNGEYFASGSSDEQVMVWKT 299

HSP 2 Score: 114.39 bits (285), Expect = 1.820e-27
Identity = 69/241 (28.63%), Postives = 110/241 (45.64%), Query Frame = 3

Query:  603 TCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            T  +   GH   V+ V F P+   L++ S D ++ +W          F GH D +  VK +  G LIAS S D +VR+W  + K     F+ H   V+ + + G        Q+LL                           + S D+++++W  +    L++L  H NWV+   F P G+ ++S SDDKTI++WD  ++ C  T      FV +++FH +   +  G  D  VKVW+ R
Sbjct:    9 TLERHFKGHRDTVTSVDFNPNMKQLVTGSMDSSLMIWHFKPHMRAYRFVGHKDAILSVKFSPSGHLIASASRDKTVRLWVPSVKGESTVFKAHTATVRSVDFSGD------GQSLL---------------------------TASDDKSLKVWTVHRQKFLYSLNAHMNWVRCAKFSPDGRLIVSGSDDKTIKLWDRTSKDCVHTFYDPGGFVNSVEFHPSGTCIAAGGTDSTVKVWDIR 216

HSP 3 Score: 98.9821 bits (245), Expect = 2.856e-22
Identity = 59/178 (33.15%), Postives = 88/178 (49.44%), Query Frame = 3

Query:  366 LKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQC 899
            L  H   + C +F P   + VSGS+D TIK+WD  S D   T       V  + F PSG  +A+   D  +K+WD      ++    H   V+ VSF PSG++L+SAS D T+K+ ++  G    T  GH      V  + +G   AS S+D  V VW     +  FD  +++ V++ 
Sbjct:  140 LNAHMNWVRCAKFSPDGRLIVSGSDDKTIKLWDRTSKDCVHTFYDPGGFVNSVEFHPSGTCIAAGGTDSTVKVWDIRMNKLLQHYQAHTGAVNSVSFHPSGNYLVSASSDTTLKILDLMEGRLFYTLHGHQGPATSVVFSRNGEYFASGSSDEQVMVW-----KTNFDKVDYQEVLRT 312

HSP 4 Score: 93.5893 bits (231), Expect = 1.677e-20
Identity = 61/247 (24.70%), Postives = 104/247 (42.11%), Query Frame = 3

Query:  336 WLPRIPARH-VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTN 1073
            W+P +     V K H A++  V F       ++ S+D ++K+W      +  +L  H N V+   F P G+L+ S S D  IKLWD     CV T       V+ V F PSG  + +   D T+K+W++     +Q ++ H+  V  V  +  G+ + S S+D ++++  +      +    H+     +V+                   + NG+                ASGS D  + +W TN
Sbjct:   87 WVPSVKGESTVFKAHTATVRSVDFSGDGQSLLTASDDKSLKVWTVHRQKFLYSLNAHMNWVRCAKFSPDGRLIVSGSDDKTIKLWDRTSKDCVHTFYDPGGFVNSVEFHPSGTCIAAGGTDSTVKVWDIRMNKLLQHYQAHTGAVNSVSFHPSGNYLVSASSDTTLKILDLMEGRLFYTLHGHQGPATSVVF-------------------SRNGE--------------YFASGSSDEQVMVWKTN 300

[Close]

BLAST of lissencephaly-1 vs. Ensembl Nematostella
Match: EDO34865 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SN68])

HSP 1 Score: 160.229 bits (404), Expect = 6.558e-44
Identity = 95/319 (29.78%), Postives = 152/319 (47.65%), Query Frame = 3

Query:  363 VLKGHRASITCVRFH-PLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
             L+GH+  +  + F+ P  +   +GS D T K+W+ E+G    T RGH+  +  LAF+P   ++A+ S D   KLWD      + TLSGH   +   +F  +G  LL+ S D T+ +W+  +G  V T  GH   +   + NFD S I + S D + ++W     +C    R H                       DD+ +    D + +L          +A+ S D T R+++  T  CL  L GH   + ++ F+ QG  LL+AS DKT R+WD    +C + LE H   + +  F+ +   ++TGS D   ++W
Sbjct:  129 TLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWNAETGKCYHTYRGHSAEIVCLAFNPQSTVIATGSMDTTAKLWDVQTGAEISTLSGHSAEIISCAFNSTGTQLLTGSFDHTVSVWDTRSGRRVHTLIGHRGEISNAQFNFDCSFIVTGSMDKTCKIWDAGTGKCIGTLRGH-----------------------DDEVLDVAFDYTGQL----------IATASADGTGRVYNALTHHCLSKLEGHEGEISKITFNAQGTRLLTASSDKTARLWDPNTGKCLQVLEGHTDEIFSCAFNYDGDIIITGSKDNTCRLW 414

HSP 2 Score: 150.214 bits (378), Expect = 3.472e-40
Identity = 89/277 (32.13%), Postives = 127/277 (45.85%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIW 1190
            H  +GH A I C+ F+P   V  +GS D T K+WD ++G    TL GH+  +   AF+ +G  L + S D  + +WD      V TL GH   +S   F      +++ S DKT K+W+  TG C+ T  GH D V  V  ++ G LIA+ S D + RV++     C      HE  +  I +  Q                                G  LL + S D+T RLWD NTG CL  L GH + +    F+  G  +++ S D T R+W
Sbjct:  171 HTYRGHSAEIVCLAFNPQSTVIATGSMDTTAKLWDVQTGAEISTLSGHSAEIISCAFNSTGTQLLTGSFDHTVSVWDTRSGRRVHTLIGHRGEISNAQFNFDCSFIVTGSMDKTCKIWDAGTGKCIGTLRGHDDEVLDVAFDYTGQLIATASADGTGRVYNALTHHCLSKLEGHEGEISKITFNAQ--------------------------------GTRLL-TASSDKTARLWDPNTGKCLQVLEGHTDEIFSCAFNYDGDIIITGSKDNTCRLW 414

HSP 3 Score: 126.716 bits (317), Expect = 8.153e-32
Identity = 83/303 (27.39%), Postives = 138/303 (45.54%), Query Frame = 3

Query:  486 RTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSF-MPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANK--------------ECKFDFR-------EHEHVVQCIVW---GGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            + LR H   + ++AF+ SG    + S D   K+WD        TL GH + V  ++F  P GD + + S DKT KLW   TG C  T+ GHS  +  +  N   ++IA+ S D + ++W +                  C F+           +H V   VW    G+++H                G+ SN    +    C  + +GS D+T ++WD  TG C+  L GH++ V ++ F   G+ + +AS D T R+++     C   LE H+  ++ I F+     ++T S D+  ++W+
Sbjct:   86 KILRAHILPLTNVAFNKSGTSFITGSYDRTCKVWDTASGEETLTLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWNAETGKCYHTYRGHSAEIVCLAFNPQSTVIATGSMDTTAKLWDVQTGAEISTLSGHSAEIISCAFNSTGTQLLTGSFDHTVS--VWDTRSGRRVHTLIGH----------RGEISNAQFNFD---CSFIVTGSMDKTCKIWDAGTGKCIGTLRGHDDEVLDVAFDYTGQLIATASADGTGRVYNALTHHCLSKLEGHEGEISKITFNAQGTRLLTASSDKTARLWD 373

HSP 4 Score: 109.768 bits (273), Expect = 4.760e-26
Identity = 73/250 (29.20%), Postives = 118/250 (47.20%), Query Frame = 3

Query:  600 FTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFD-GSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKI-----HMETNQALLDDKQ----MTSNGDSSNKLD-GYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            F   K L  H   ++ V+F  SG   ++ S D+T K+W+ ++G    T EGH + V  +  N   G  IA+ S D + ++W+    +C   +R H   + C+ +  Q        M+T   L D +      T +G S+  +   +  +G  LL +GS D T+ +WDT +G  +  LIGH   +    F+    F+++ S DKT +IWD    +C  TL  HD  V  + F      + T S D   +V+
Sbjct:   82 FYLFKILRAHILPLTNVAFNKSGTSFITGSYDRTCKVWDTASGEETLTLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWNAETGKCYHTYRGHSAEIVCLAFNPQSTVIATGSMDTTAKLWDVQTGAEISTLSGHSAEIISCAFNSTGTQLL-TGSFDHTVSVWDTRSGRRVHTLIGHRGEISNAQFNFDCSFIVTGSMDKTCKIWDAGTGKCIGTLRGHDDEVLDVAFDYTGQLIATASADGTGRVY 330

HSP 5 Score: 72.7886 bits (177), Expect = 8.296e-14
Identity = 50/199 (25.13%), Postives = 81/199 (40.70%), Query Frame = 3

Query:  729 YCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            Y  +    H   +  V  N  G+   + S D + +VW  A+ E       H++VV  I +                     N    +K+           A+GS D+T +LW+  TG C     GH+  +  L F+PQ   + + S D T ++WD++      TL  H   + +  F+     ++TGS D  V VW+ R
Sbjct:   83 YLFKILRAHILPLTNVAFNKSGTSFITGSYDRTCKVWDTASGEETLTLEGHKNVVYAIAF---------------------NNPYGDKI-----------ATGSFDKTCKLWNAETGKCYHTYRGHSAEIVCLAFNPQSTVIATGSMDTTAKLWDVQTGAEISTLSGHSAEIISCAFNSTGTQLLTGSFDHTVSVWDTR 249

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BLAST of lissencephaly-1 vs. Ensembl Nematostella
Match: EDO49767 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFR6])

HSP 1 Score: 150.214 bits (378), Expect = 1.741e-41
Identity = 89/325 (27.38%), Postives = 143/325 (44.00%), Query Frame = 3

Query:  342 PRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW 1316
            P  P    + G   +I  +   P     ++G  D +I++WDYE+G     L  HT  V  LA  P    L S + D  +K+WD    + V TL GH + VSGV   P    ++S+S DKT+K+W+V T   V + +GH   VR +    DG  + S S D ++R+W++         R H   V C+                DDK                        SGS D  +++WD  +   + +L+GH + +  +   P G  ++S+ DD  +++W L++     +L  H   V  +    +   +V+GS D   K+W
Sbjct:    1 PGGPLLRTIDGRSRTILGIAVTPDTKKIITGGADGSIRVWDYETGKELNKLLDHTKLVYTLALSPHADFLVSGAFDHTVKIWDMDTLSLVHTLKGHKNWVSGVLVTPDSKRIISSSYDKTVKIWDVETCAFVNSLDGHDGHVRGIAITSDGRRLVSASQDRTLRIWNLETFAHVSTLRGHSETVYCVCCSP------------DDK---------------------FAISGSEDTMVKIWDLESAKEVRSLVGHTSDIFAVAVTPDGSKVISSGDDTQVKVWSLESGEELASLHGHSESVRIVTVSPDGLTIVSGSEDATFKIW 292

HSP 2 Score: 83.1889 bits (204), Expect = 1.136e-17
Identity = 52/237 (21.94%), Postives = 106/237 (44.73%), Query Frame = 3

Query:  609 VKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            ++T+ G    + G++  P    +++   D +I++W+  TG  +     H+  V  +  +     + S + D++V++W M         + H++ V  ++               D K++ S+                     S D+T+++WD  T   + +L GH+  V+ +     G+ L+SAS D+T+RIW+L+      TL  H   V  +    +  + ++GS D +VK+W+
Sbjct:    6 LRTIDGRSRTILGIAVTPDTKKIITGGADGSIRVWDYETGKELNKLLDHTKLVYTLALSPHADFLVSGAFDHTVKIWDMDTLSLVHTLKGHKNWVSGVL------------VTPDSKRIISS---------------------SYDKTVKIWDVETCAFVNSLDGHDGHVRGIAITSDGRRLVSASQDRTLRIWNLETFAHVSTLRGHSETVYCVCCSPDDKFAISGSEDTMVKIWD 209

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BLAST of lissencephaly-1 vs. Ensembl Medaka
Match: PAFAH1B1 (lissencephaly-1 homolog A [Source:NCBI gene;Acc:101158788])

HSP 1 Score: 546.199 bits (1406), Expect = 0.000e+0
Identity = 253/427 (59.25%), Postives = 333/427 (77.99%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI-LGE-IDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA++ + E +DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    +++    G+K    +W+PR P R+ + GHRA +T V FHP+++V V+ SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV+TGYCV+TF GH +WVR+V+PN DGSL+ASCSND +VRVW +++KECK + REHEHVV+CI W     H    +A        S    S K   +       L SGSRD+TI++WD + G+CL  L+GH+NWV+ ++FHP G+F++S +DDKTIRIWD KN+RC KTL AH+HFVT++DFH+++PYVVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDMNEDVDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----MTHGGPVGQKRDPKEWIPRPPERYAMSGHRAPVTRVIFHPVFSVMVTASEDATIKVWDYEAGDFERTLKGHTDSVQDVSFDQTGKLLASCSADMSIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFTGHREWVRMVRPNQDGSLLASCSNDQTVRVWVVSSKECKAELREHEHVVECIAWAPDSAHPTILEA------TGSESKKSGKPGPF-------LLSGSRDKTIKMWDVSIGICLMTLVGHDNWVRGVLFHPGGRFIVSCADDKTIRIWDFKNKRCMKTLSAHEHFVTSLDFHKSAPYVVTGSVDQTVKVWECR 410

[Close]

BLAST of lissencephaly-1 vs. Ensembl Medaka
Match: PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1 [Source:NCBI gene;Acc:101169717])

HSP 1 Score: 540.806 bits (1392), Expect = 0.000e+0
Identity = 254/427 (59.48%), Postives = 330/427 (77.28%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILG--EIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    I+      +K    +W+PR P R+ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV+TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A+KECK + REHEHVV+CI W  +       +A        S    S K   +       L SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FHP GKF++S +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ +P+VVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDNNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----ITLGGPVTQKRDPKEWIPRPPERYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFAGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKECKAELREHEHVVECISWAPESASPTILEA------TGSETKKSGKPGPF-------LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGILFHPGGKFIVSCADDKTLRIWDYKNKRCMKTLCAHEHFVTSLDFHKAAPFVVTGSVDQTVKVWECR 410

[Close]

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILG--EIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            MVLS+RQ +ELN++IA+YL  NGY+E Y+ FK EA++    E+DKK++GLLEKKWTSVIRLQKKV +LES+L E K+E    I+      +K    +W+PR P R+ L GHR+ +T V FHP+++V VS SEDATIK+WDYE+GD+ERTL+GHT+ VQD++FD +GKLLASCSADM IKLWDF  F C++T+ GHDHNVS V+ MP+GDH++SASRDKTIK+WEV+TGYCV+TF GH +WVR+V+PN DG+LIASCSND +VRVW +A+KECK + REHEHVV+CI W  +       +A        S    S K   +       L SGSRD+TI++WD +TG+CL  L+GH+NWV+ ++FHP GKF++S +DDKT+RIWD KN+RC KTL AH+HFVT++DFH+ +P+VVTGSVDQ VKVWECR
Sbjct:    1 MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDNNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEE----ITLGGPVTQKRDPKEWIPRPPERYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFAGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKECKAELREHEHVVECISWAPESASPTILEA------TGSETKKSGKPGPF-------LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGILFHPGGKFIVSCADDKTLRIWDYKNKRCMKTLCAHEHFVTSLDFHKAAPFVVTGSVDQTVKVWECR 410

[Close]

BLAST of lissencephaly-1 vs. Ensembl Medaka
Match: wdr5 (WD repeat domain 5 [Source:NCBI gene;Acc:101166483])

HSP 1 Score: 161.77 bits (408), Expect = 9.001e-45
Identity = 98/332 (29.52%), Postives = 161/332 (48.49%), Query Frame = 3

Query:  342 PRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFH----PQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSV--DQIVKVWE 1319
            P    +  L GH  +++ V+F P      S S D  IKIW    G +E+T+ GH   + D+A+     LL S S D  +K+WD     C+KTL GH + V   +F P  + ++S S D+++++W+V TG C++T   HSD V  V  N DGSLI S S D   R+W  A+ +C                          + L+DD     +         +  +G ++LA+ + D T++LWD + G CL    GH N  +  +F       GK+++S S+D  + IW+L+ +   + L+ H   V +   H     + + ++  D+ +K+W+
Sbjct:   33 PNYSLKFTLAGHTKAVSSVKFSPSGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVNSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL-------------------------KTLIDDDNPPVS------FVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331

HSP 2 Score: 150.214 bits (378), Expect = 1.589e-40
Identity = 97/287 (33.80%), Postives = 144/287 (50.17%), Query Frame = 3

Query:  489 TLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELV-FHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAH--DHFVTTIDFH-RNSPYVVTGSVDQIVKVWECR*SQI 1337
            TL GHT  V  + F PSG+ LAS SAD  IK+W   +    KT+SGH   +S V++    + L+SAS DKT+K+W+V++G C++T +GHS++V     N   +LI S S D SVR+W +   +C      H   V         +H               N D S            L+ S S D   R+WDT +G CL  LI  +N     V F P GK++L+A+ D T+++WD    +C KT   H  + +    +F      ++V+GS D +V +W  +  +I
Sbjct:   40 TLAGHTKAVSSVKFSPSGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVNSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA-------VHF--------------NRDGS------------LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQTKEI 293

HSP 3 Score: 131.339 bits (329), Expect = 9.970e-34
Identity = 85/299 (28.43%), Postives = 143/299 (47.83%), Query Frame = 3

Query:  321 SSSVDWLPRIPARH------VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTF-EGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSAS--DDKTIRIW 1190
            SSS D L +I   +       + GH+  I+ V +    N+ VS S+D T+KIWD  SG   +TL+GH+N+V    F+P   L+ S S D  +++WD     C+KTL  H   VS V F   G  ++S+S D   ++W+ ++G C++T  +  +  V  VK + +G  I + + DN++++W  +  +C   +  H++   CI                                 + ++G   + SGS D  + +W+  T   +  L GH + V     HP    + SA+  +DKTI++W
Sbjct:   62 SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVNSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI------------------------------FANFSVTGGKWIVSGSEDNMVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330

[Close]

BLAST of lissencephaly-1 vs. Ensembl Medaka
Match: daw1 (dynein assembly factor with WD repeats 1 [Source:NCBI gene;Acc:101168478])

HSP 1 Score: 159.844 bits (403), Expect = 2.323e-43
Identity = 96/321 (29.91%), Postives = 148/321 (46.11%), Query Frame = 3

Query:  366 LKGHRASITCVRFH-PLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            L+GH   +  V F+ P  +   +GS D T K+W  ++G    TLRGH   ++ LAF+P   L+A+ S D   KLWD      V TL GH   +  + F   G  L++ S D+T+ +W+V+T   V    GH+  +   + N+D SLI S S DN+ ++W   +  C      H   V                                 LD    S   L+A  S D T  +++  T  C+  L GH   + ++ F PQG  +L+AS DKT R+WD++   C + L  H   + +  F+     ++TGS D   ++W C+
Sbjct:  128 LEGHTNIVAAVAFNIPYGDKIATGSFDRTCKLWCAQTGSCLHTLRGHLAEIRCLAFNPQSTLVATGSTDASAKLWDVKRGKEVATLKGHSAEILSLCFNSVGSQLVTGSSDQTLAVWDVATERLVHMLAGHAGEISNAQFNWDCSLIVSGSLDNTCKLWEAVSGRCVATLAAHTEEV---------------------------------LDVCFDSTGQLVAIASADGTASVFNAATYECMARLEGHEGEISKICFSPQGNTILTASSDKTARLWDVQTGGCLQILTGHTLEIFSCAFNYEGDTIITGSADNTCQIWRCK 415

HSP 2 Score: 122.479 bits (306), Expect = 6.217e-30
Identity = 60/160 (37.50%), Postives = 94/160 (58.75%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVW 839
            H+L GH   I+  +F+   ++ VSGS D T K+W+  SG    TL  HT  V D+ FD +G+L+A  SAD    +++   + C+  L GH+  +S + F P G+ +L+AS DKT +LW+V TG C+Q   GH+  +     N++G  I + S DN+ ++W
Sbjct:  253 HMLAGHAGEISNAQFNWDCSLIVSGSLDNTCKLWEAVSGRCVATLAAHTEEVLDVCFDSTGQLVAIASADGTASVFNAATYECMARLEGHEGEISKICFSPQGNTILTASSDKTARLWDVQTGGCLQILTGHTLEIFSCAFNYEGDTIITGSADNTCQIW 412

[Close]

BLAST of lissencephaly-1 vs. Planmine SMEST
Match: SMESG000035997.1 (SMESG000035997.1)

HSP 1 Score: 657.136 bits (1694), Expect = 0.000e+0
Identity = 319/350 (91.14%), Postives = 329/350 (94.00%), Query Frame = 3

Query:   51 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLI 1100
            MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI G++ K F   L+K    +   +KK+       ++ KK+THDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNL+
Sbjct:    1 MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKI-GKLIKNFQDFLKKSGHQLFVYKKKLMIWRVSFKKPKKKTHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLV 349

HSP 2 Score: 108.997 bits (271), Expect = 1.710e-25
Identity = 62/213 (29.11%), Postives = 102/213 (47.89%), Query Frame = 3

Query:  615 TLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTI 1253
             L GH  +++ V F P  +  +S S D TIK+W+  +G   +T  GH++ V+ +  +  G L+ASCS D  +++W      C      H+H V  +                                 +  SG HLL S SRD+TI+LW+ +TG C+    GH++WV+ +  +  G  + S S+D ++R+W + N+ C+     H+H V  I
Sbjct:  104 VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGV--------------------------------SFMPSGDHLL-SASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCI 283

HSP 3 Score: 85.8853 bits (211), Expect = 7.270e-18
Identity = 41/100 (41.00%), Postives = 59/100 (59.00%), Query Frame = 3

Query: 1020 HLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            ++  SGS D TI++WD  +G     L GH N VQ+L F P GK L S S D  I++WD     C KTL  HDH V+ + F  +  ++++ S D+ +K+WE
Sbjct:  122 NVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWE 221

HSP 4 Score: 71.633 bits (174), Expect = 3.219e-13
Identity = 40/106 (37.74%), Postives = 58/106 (54.72%), Query Frame = 3

Query: 1023 LLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW-----ECR 1325
            LLAS S D  I+LWD     C+  L GH++ V  + F P G  LLSAS DKTI++W++    C +T E H  +V  +  + +   + + S D  V+VW     EC+
Sbjct:  165 LLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECK 270

HSP 5 Score: 65.855 bits (159), Expect = 2.436e-11
Identity = 31/32 (96.88%), Postives = 31/32 (96.88%), Query Frame = 1

Query: 1099 LATIIGFKSLYFIHRENFFSVHQTIRLYAYGI 1194
            LA IIGFKSLYFIHRENFFSVHQTIRLYAYGI
Sbjct:  365 LAIIIGFKSLYFIHRENFFSVHQTIRLYAYGI 396

[Close]

BLAST of lissencephaly-1 vs. Planmine SMEST
Match: SMESG000054739.1 (SMESG000054739.1)

HSP 1 Score: 648.662 bits (1672), Expect = 0.000e+0
Identity = 312/313 (99.68%), Postives = 313/313 (100.00%), Query Frame = 3

Query:  162 LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLI 1100
            LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNL+
Sbjct:    3 LGEIDKKFSGLLEKKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRIPARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLV 315

HSP 2 Score: 108.227 bits (269), Expect = 1.897e-25
Identity = 62/213 (29.11%), Postives = 102/213 (47.89%), Query Frame = 3

Query:  615 TLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTI 1253
             L GH  +++ V F P  +  +S S D TIK+W+  +G   +T  GH++ V+ +  +  G L+ASCS D  +++W      C      H+H V  +                                 +  SG HLL S SRD+TI+LW+ +TG C+    GH++WV+ +  +  G  + S S+D ++R+W + N+ C+     H+H V  I
Sbjct:   70 VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGV--------------------------------SFMPSGDHLL-SASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCI 249

HSP 3 Score: 85.8853 bits (211), Expect = 6.874e-18
Identity = 41/100 (41.00%), Postives = 59/100 (59.00%), Query Frame = 3

Query: 1020 HLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            ++  SGS D TI++WD  +G     L GH N VQ+L F P GK L S S D  I++WD     C KTL  HDH V+ + F  +  ++++ S D+ +K+WE
Sbjct:   88 NVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWE 187

HSP 4 Score: 71.2478 bits (173), Expect = 3.537e-13
Identity = 40/106 (37.74%), Postives = 58/106 (54.72%), Query Frame = 3

Query: 1023 LLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVW-----ECR 1325
            LLAS S D  I+LWD     C+  L GH++ V  + F P G  LLSAS DKTI++W++    C +T E H  +V  +  + +   + + S D  V+VW     EC+
Sbjct:  131 LLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECK 236

HSP 5 Score: 66.2402 bits (160), Expect = 1.618e-11
Identity = 31/32 (96.88%), Postives = 31/32 (96.88%), Query Frame = 1

Query: 1099 LATIIGFKSLYFIHRENFFSVHQTIRLYAYGI 1194
            LA IIGFKSLYFIHRENFFSVHQTIRLYAYGI
Sbjct:  331 LAIIIGFKSLYFIHRENFFSVHQTIRLYAYGI 362

[Close]

BLAST of lissencephaly-1 vs. Planmine SMEST
Match: SMESG000024482.1 (SMESG000024482.1)

HSP 1 Score: 146.362 bits (368), Expect = 3.791e-38
Identity = 88/319 (27.59%), Postives = 143/319 (44.83%), Query Frame = 3

Query:  366 LKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWEC 1322
             KGH+  +TCV F+P  +   SG  D+ + IW+++         GH + +  + F P+G+L+AS S D  ++LW             H   V  V        +++ S DKTIK+W++       +   H +WVR V+ + DG LIAS S+D ++++W   N+EC   F+EH   V  + +                     NG                +ASG  D  + +WD      L +   H + V  + FHP G FL+S+SDD +++I+DL   R   T++ H+  +    F        +G  D  V +W+ 
Sbjct:   10 FKGHKDKVTCVDFNPNSSQLASGGIDSCLMIWNFKPQTRAYRFVGHEDAILSVKFSPTGQLVASASRDKTVRLWVPSIKGESLVFRAHTATVRSVDISCDNLEMVTGSDDKTIKVWKMHRQKFSYSLNEHKNWVRCVRFSSDGQLIASSSDDKTIKLWDRHNQECIHTFQEHGGFVPSLAF-------------------HPNGS--------------YIASGGTDSHVNIWDIRMNKLLQHYTSHTSPVNAVSFHPSGNFLISSSDDSSMKIYDLLEGRLLYTVQGHEGPILGTAFSHCGEMFASGGADHQVFLWQA 295

HSP 2 Score: 114.775 bits (286), Expect = 3.742e-27
Identity = 69/234 (29.49%), Postives = 103/234 (44.02%), Query Frame = 3

Query:  624 GHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            GH   V+ V F P+   L S   D  + +W          F GH D +  VK +  G L+AS S D +VR+W  + K     FR H   V+ +      + M T                                 GS D+TI++W  +     ++L  H NWV+ + F   G+ + S+SDDKTI++WD  N+ C  T + H  FV ++ FH N  Y+ +G  D  V +W+ R
Sbjct:   12 GHKDKVTCVDFNPNSSQLASGGIDSCLMIWNFKPQTRAYRFVGHEDAILSVKFSPTGQLVASASRDKTVRLWVPSIKGESLVFRAHTATVRSVDISCDNLEMVT---------------------------------GSDDKTIKVWKMHRQKFSYSLNEHKNWVRCVRFSSDGQLIASSSDDKTIKLWDRHNQECIHTFQEHGGFVPSLAFHPNGSYIASGGTDSHVNIWDIR 212

HSP 3 Score: 93.9745 bits (232), Expect = 2.916e-20
Identity = 52/184 (28.26%), Postives = 90/184 (48.91%), Query Frame = 3

Query:  336 WLPRIPARH-VLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHE 884
            W+P I     V + H A++  V         V+GS+D TIK+W      +  +L  H N V+ + F   G+L+AS S D  IKLWD     C+ T   H   V  ++F P+G ++ S   D  + +W++     +Q +  H+  V  V  +  G+ + S S+D+S++++ +      +  + HE
Sbjct:   83 WVPSIKGESLVFRAHTATVRSVDISCDNLEMVTGSDDKTIKVWKMHRQKFSYSLNEHKNWVRCVRFSSDGQLIASSSDDKTIKLWDRHNQECIHTFQEHGGFVPSLAFHPNGSYIASGGTDSHVNIWDIRMNKLLQHYTSHTSPVNAVSFHPSGNFLISSSDDSSMKIYDLLEGRLLYTVQGHE 266

HSP 4 Score: 71.2478 bits (173), Expect = 6.573e-13
Identity = 35/120 (29.17%), Postives = 57/120 (47.50%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEV 719
            H  + H   +  + FHP  +   SG  D+ + IWD       +    HT+ V  ++F PSG  L S S D  +K++D +E   + T+ GH+  + G +F   G+   S   D  + LW+ 
Sbjct:  176 HTFQEHGGFVPSLAFHPNGSYIASGGTDSHVNIWDIRMNKLLQHYTSHTSPVNAVSFHPSGNFLISSSDDSSMKIYDLLEGRLLYTVQGHEGPILGTAFSHCGEMFASGGADHQVFLWQA 295

[Close]

BLAST of lissencephaly-1 vs. Planmine SMEST
Match: SMESG000008519.1 (SMESG000008519.1)

HSP 1 Score: 141.739 bits (356), Expect = 6.532e-38
Identity = 95/322 (29.50%), Postives = 145/322 (45.03%), Query Frame = 3

Query:  366 LKGHRASITCVRFH-PLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPS--GDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDT-NTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            L+GH+  +  + ++ P  +  V+GS D T K+W    G    T +GHT  V  + F+PS  L+ +   D    LWD     CV  L GH   V  + F  +  G HL++ S D T+ LW+V  G  V    GH   +     NFDG+ +A+ S D S+++W         D R           G + +              T  G +   LD    +    +AS   D T+RLWD  +     F   GH   V ++ F+PQG  LLSAS DK+ R W+    +  + LE H   + +  F+ +   ++TGS D   ++W+
Sbjct:    8 LEGHKNVVYSIAYNLPFSDKIVTGSFDKTAKMWSANDGSLYHTFKGHTAEVVCVQFNPSSTLVGTGGMDTLAMLWDVESGKCVSNLQGHTAEVISLQFGQAHNGKHLITGSFDHTVILWDVHNGRRVSQLIGHDAEISAAVFNFDGTYVATASMDKSIKIW---------DLR----------MGARDL-------------FTLAGHTDEVLDVTFDNVGKQVASAGADNTVRLWDVKDFSKPSFIFKGHEAEVSKVTFNPQGTVLLSASADKSARTWNTTTGKVIQVLEGHTDEIFSCAFNYDGSKIITGSKDNTCRIWQ 297

HSP 2 Score: 125.561 bits (314), Expect = 3.588e-32
Identity = 87/281 (30.96%), Postives = 128/281 (45.55%), Query Frame = 3

Query:  360 HVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRGHTNHVQDLAFDPS--GKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYC-VQTFEGHSDWVRVVKPNFDGSLIASCSNDNSVRVWSMAN-KECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIW 1190
            H  KGH A + CV+F+P   +  +G  D    +WD ESG     L+GHT  V  L F  +  GK L + S D  + LWD      V  L GHD  +S   F   G ++ +AS DK+IK+W++  G   + T  GH+D V  V  +  G  +AS   DN+VR+W + +  +  F F+ HE  V  + +  Q                                   +L S S D++ R W+T TG  +  L GH + +    F+  G  +++ S D T RIW
Sbjct:   49 HTFKGHTAEVVCVQFNPSSTLVGTGGMDTLAMLWDVESGKCVSNLQGHTAEVISLQFGQAHNGKHLITGSFDHTVILWDVHNGRRVSQLIGHDAEISAAVFNFDGTYVATASMDKSIKIWDLRMGARDLFTLAGHTDEVLDVTFDNVGKQVASAGADNTVRLWDVKDFSKPSFIFKGHEAEVSKVTFNPQGT---------------------------------VLLSASADKSARTWNTTTGKVIQVLEGHTDEIFSCAFNYDGSKIITGSKDNTCRIW 296

HSP 3 Score: 73.9442 bits (180), Expect = 2.601e-14
Identity = 56/203 (27.59%), Postives = 86/203 (42.36%), Query Frame = 3

Query:  726 GYCVQTFEGHSDWVRVVKPNFDGS-LIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHP--QGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTTIDFHRNSPYVVTGSVDQIVKVWECR 1325
            G  + T EGH + V  +  N   S  I + S D + ++WS  +      F+ H   V C+ +                     N  S+            L+ +G  D    LWD  +G C+ NL GH   V  L F     GK L++ S D T+ +WD+ N R    L  HD  ++   F+ +  YV T S+D+ +K+W+ R
Sbjct:    2 GTTLFTLEGHKNVVYSIAYNLPFSDKIVTGSFDKTAKMWSANDGSLYHTFKGHTAEVVCVQF---------------------NPSST------------LVGTGGMDTLAMLWDVESGKCVSNLQGHTAEVISLQFGQAHNGKHLITGSFDHTVILWDVHNGRRVSQLIGHDAEISAAVFNFDGTYVATASMDKSIKIWDLR 171

[Close]

BLAST of lissencephaly-1 vs. Planmine SMEST
Match: SMESG000076568.1 (SMESG000076568.1)

HSP 1 Score: 131.339 bits (329), Expect = 5.437e-34
Identity = 96/343 (27.99%), Postives = 152/343 (44.31%), Query Frame = 3

Query:  345 RIPARHVLKGHRASITCVRFHPLY-NVFVSGSEDATIKIWDYES-----GDYERTLRGHTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGVSFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFE--GHSDWVRVVK--PNFDGSLIASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALLDDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLIGHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAH--------DHFVTTIDFHRNSPYVVTGSVDQIVKVWE 1319
            ++  R  L GH   IT +  +P+Y N  +S S D ++ IW+        G  +R L+GH   V D+     G+   S S D  ++LWD       +   GH  +V  V+F      ++S SRD TIKLW  + G C  T +  GH+DWV  V+  P  +   I SC  D  V+VW+++N  CK       H                    L+   ++ +G               L ASG +D    LWD + G  L+ L G  + +  L+F P  ++ L A+   +I+IWDL+N+     L+A            VT + + ++   +  G  D +++VW+
Sbjct:    4 QLTLRGSLTGHDGPITQIATNPIYPNTLISASRDKSLIIWELNRDENSFGYAKRALKGHNGFVSDVVMSSDGQFALSGSWDGTLRLWDLTSGQTTRRFVGHTKDVLSVAFSADNRQIVSGSRDGTIKLWN-TLGVCKYTIQEDGHTDWVSCVRFSPTSENPSIVSCGWDKVVKVWNLSN--CKLRTNHFGH-----------------NGYLNTVAVSPDGS--------------LCASGGKDGQAMLWDLSEGRHLYTLEG-GDIINALIFSPN-RYWLCAATGSSIKIWDLENKVLVGDLKAEVIDNKSKATAEVTCLSWSQDGQTLFAGYSDNVIRVWQ 310

The following BLAST results are available for this feature:

BLAST of lissencephaly-1 vs. Ensembl Human
BLAST of lissencephaly-1 vs. Ensembl Celegans
BLAST of lissencephaly-1 vs. Ensembl Fly
BLAST of lissencephaly-1 vs. Ensembl Zebrafish
BLAST of lissencephaly-1 vs. Ensembl Xenopus
BLAST of lissencephaly-1 vs. Ensembl Mouse
BLAST of lissencephaly-1 vs. UniProt/SwissProt
BLAST of lissencephaly-1 vs. TrEMBL
BLAST of lissencephaly-1 vs. Ensembl Cavefish
BLAST of lissencephaly-1 vs. Ensembl Sea Lamprey
BLAST of lissencephaly-1 vs. Ensembl Yeast
BLAST of lissencephaly-1 vs. Ensembl Nematostella
BLAST of lissencephaly-1 vs. Ensembl Medaka
BLAST of lissencephaly-1 vs. Planmine SMEST

BLAST of lissencephaly-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PAFAH1B1	0.000e+0	58.78	platelet activating factor acetylhydrolase 1b regu...	[more]
PAFAH1B1	5.519e-69	49.07	platelet activating factor acetylhydrolase 1b regu...	[more]
DAW1	4.326e-46	31.56	dynein assembly factor with WD repeats 1 [Source:H...	[more]
WDR5	1.016e-44	28.81	WD repeat domain 5 [Source:HGNC Symbol;Acc:HGNC:12...	[more]
WDR5B	4.360e-43	29.49	WD repeat domain 5B [Source:HGNC Symbol;Acc:HGNC:1...	[more]

BLAST of lissencephaly-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lis-1	9.573e-161	51.41	Lissencephaly-1 homolog [Source:UniProtKB/Swiss-P...	[more]
wdr-5.1	6.952e-42	31.48	WD repeat-containing protein wdr-5.1 [Source:UniP...	[more]
wdr-5.1	6.952e-42	31.48	WD repeat-containing protein wdr-5.1 [Source:UniP...	[more]
W07E6.2	5.713e-35	27.25	pep chromosome:WBcel235:II:480722:484386:-1 gene:W...	[more]
wdr-5.2	6.303e-35	29.72	WD repeat-containing protein wdr-5.2 [Source:UniP...	[more]

BLAST of lissencephaly-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Lis-1	3.133e-178	57.14	gene:FBgn0015754 transcript:FBtr0087241	[more]
Lis-1	3.133e-178	57.14	gene:FBgn0015754 transcript:FBtr0304747	[more]
Lis-1	3.133e-178	57.14	gene:FBgn0015754 transcript:FBtr0087240	[more]
Lis-1	3.133e-178	57.14	gene:FBgn0015754 transcript:FBtr0087236	[more]
wds	9.537e-42	28.92	gene:FBgn0040066 transcript:FBtr0308566	[more]

BLAST of lissencephaly-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pafah1b1b	0.000e+0	60.19	platelet-activating factor acetylhydrolase 1b, reg...	[more]
pafah1b1b	0.000e+0	60.19	platelet-activating factor acetylhydrolase 1b, reg...	[more]
pafah1b1a	0.000e+0	58.78	platelet-activating factor acetylhydrolase 1b, reg...	[more]
pafah1b1a	0.000e+0	58.78	platelet-activating factor acetylhydrolase 1b, reg...	[more]
daw1	1.366e-45	32.30	dynein assembly factor with WDR repeat domains 1 [...	[more]

BLAST of lissencephaly-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pafah1b1	0.000e+0	59.95	platelet activating factor acetylhydrolase 1b regu...	[more]
pafah1b1	0.000e+0	58.84	platelet activating factor acetylhydrolase 1b regu...	[more]
pafah1b1	7.419e-148	53.37	platelet activating factor acetylhydrolase 1b regu...	[more]
daw1	1.457e-45	30.94	dynein assembly factor with WDR repeat domains 1 [...	[more]
daw1	1.533e-45	30.94	dynein assembly factor with WDR repeat domains 1 [...	[more]

BLAST of lissencephaly-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pafah1b1	0.000e+0	58.78	platelet-activating factor acetylhydrolase, isofor...	[more]
Pafah1b1	0.000e+0	58.78	platelet-activating factor acetylhydrolase, isofor...	[more]
Wdr5	6.972e-45	28.81	WD repeat domain 5 [Source:MGI Symbol;Acc:MGI:2155...	[more]
Daw1	2.882e-44	31.25	dynein assembly factor with WDR repeat domains 1 [...	[more]
Wdr5b	7.619e-43	29.39	WD repeat domain 5B [Source:MGI Symbol;Acc:MGI:191...	[more]

BLAST of lissencephaly-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|C3XVT5\|LIS1_BRAFL	0.000e+0	61.65	Lissencephaly-1 homolog OS=Branchiostoma floridae ...	[more]
sp\|Q803D2\|LIS1B_DANRE	0.000e+0	60.19	Lissencephaly-1 homolog B OS=Danio rerio OX=7955 G...	[more]
sp\|Q4RJN5\|LIS1_TETNG	0.000e+0	59.72	Lissencephaly-1 homolog OS=Tetraodon nigroviridis ...	[more]
sp\|P43034\|LIS1_HUMAN	0.000e+0	58.78	Platelet-activating factor acetylhydrolase IB subu...	[more]
sp\|Q6NZH4\|LIS1_XENTR	0.000e+0	59.95	Lissencephaly-1 homolog OS=Xenopus tropicalis OX=8...	[more]

BLAST of lissencephaly-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
I0E0N1	0.000e+0	100.00	Lissencephaly-1 homolog OS=Schmidtea mediterranea ...	[more]
A0A4S2MH89	0.000e+0	58.55	Lissencephaly-1 homolog OS=Opisthorchis felineus O...	[more]
A0A3P8P0Z6	0.000e+0	60.89	Lissencephaly-1 homolog OS=Astatotilapia callipter...	[more]
A0A3P9DHN1	0.000e+0	60.89	Lissencephaly-1 homolog OS=Maylandia zebra OX=1065...	[more]
A0A3B4GNF4	0.000e+0	60.89	Lissencephaly-1 homolog OS=Pundamilia nyererei OX=...	[more]

BLAST of lissencephaly-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pafah1b1b	0.000e+0	60.89	lissencephaly-1 homolog B [Source:NCBI gene;Acc:10...	[more]
pafah1b1a	0.000e+0	59.72	lissencephaly-1 homolog A-like [Source:NCBI gene;A...	[more]
pafah1b1a	2.002e-168	57.95	lissencephaly-1 homolog A-like [Source:NCBI gene;A...	[more]
pafah1b1b	4.051e-128	46.29	lissencephaly-1 homolog B [Source:NCBI gene;Acc:10...	[more]
wdr5	4.323e-45	29.52	WD repeat domain 5 [Source:NCBI gene;Acc:103033424...	[more]

BLAST of lissencephaly-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pafah1b1b	2.291e-161	58.52	platelet-activating factor acetylhydrolase 1b, reg...	[more]
POC1A	8.356e-46	32.09	POC1 centriolar protein A [Source:HGNC Symbol;Acc:...	[more]
ENSPMAT00000008862.1	5.713e-42	32.73	pep scaffold:Pmarinus_7.0:GL476579:86637:114999:1 ...	[more]
ENSPMAT00000004902.1	2.478e-38	29.38	pep scaffold:Pmarinus_7.0:GL478254:5937:33805:1 ge...	[more]
ENSPMAT00000002506.1	6.894e-32	28.20	pep scaffold:Pmarinus_7.0:GL479076:26529:32136:-1 ...	[more]

BLAST of lissencephaly-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
RSA4	8.487e-35	26.87	WD-repeat protein involved in ribosome biogenesis;...	[more]
MET30	9.973e-35	31.68	F-box protein containing five copies of the WD40 m...	[more]
PAC1	1.744e-34	27.54	Involved in nuclear migration, part of the dynein/...	[more]
TUP1	1.372e-26	25.86	General repressor of transcription; forms complex ...	[more]
COP1	1.287e-25	28.67	Alpha subunit of COPI vesicle coatomer complex; co...	[more]

BLAST of lissencephaly-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO41896	0.000e+0	58.12	Lissencephaly-1 homolog [Source:UniProtKB/Swiss-P...	[more]
EDO33297	9.280e-45	29.52	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45346	1.386e-44	30.75	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34865	6.558e-44	29.78	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49767	1.741e-41	27.38	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of lissencephaly-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PAFAH1B1	0.000e+0	59.25	lissencephaly-1 homolog A [Source:NCBI gene;Acc:10...	[more]
PAFAH1B1	0.000e+0	59.48	platelet activating factor acetylhydrolase 1b regu...	[more]
PAFAH1B1	0.000e+0	59.48	platelet activating factor acetylhydrolase 1b regu...	[more]
wdr5	9.001e-45	29.52	WD repeat domain 5 [Source:NCBI gene;Acc:101166483...	[more]
daw1	2.323e-43	29.91	dynein assembly factor with WD repeats 1 [Source:N...	[more]

BLAST of lissencephaly-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000035997.1	1.710e-25	91.14	SMESG000035997.1	[more]
SMESG000054739.1	1.897e-25	99.68	SMESG000054739.1	[more]
SMESG000024482.1	3.791e-38	27.59	SMESG000024482.1	[more]
SMESG000008519.1	6.532e-38	29.50	SMESG000008519.1	[more]
SMESG000076568.1	5.437e-34	27.99	SMESG000076568.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30016141
GenBank	AFH96442.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30016141 ID=SMED30016141|Name=lissencephaly-1|organism=Schmidtea mediterranea sexual|type=transcript|length=1602bp
ATTTTGTGACTTCAAAGGATAACTAAATAATAAATTAAATATTGAAATAA
ATGGTTTTGTCAGAACGGCAAATTGAAGAATTGAACAAGTCTATTGCTGA
ATATTTGATTGATAATGGATACAAGGAAACTTATGCCATATTTAAAGGAG
AAGCCAAAATTTTAGGGGAAATAGATAAAAAATTTTCAGGACTTCTTGAA
AAAAAGTGGACATCAGTTATTCGTTTACAAAAAAAAGTTAATGATTTGGA
GAGTCAGCTTCAAGAAACCAAAAAAGAAACACATGACGTAATATCAAATG
CAACTTTTAAAGGCAGGAAATCATCATCCGTAGATTGGCTTCCTAGAATT
CCAGCCAGACATGTTCTTAAAGGCCACAGAGCATCTATAACTTGTGTGCG
CTTTCATCCATTATATAATGTCTTTGTATCTGGAAGTGAAGATGCCACGA
TAAAGATATGGGATTATGAATCTGGAGATTACGAAAGAACACTTCGGGGT
CATACTAATCATGTCCAGGATCTTGCTTTTGATCCTAGTGGAAAATTGCT
TGCCTCGTGTTCAGCTGATATGCAAATCAAATTGTGGGATTTTGTAGAAT
TTACCTGTGTGAAAACTCTATCCGGGCATGACCACAATGTATCGGGCGTA
TCATTTATGCCTTCAGGTGACCATCTATTATCAGCTAGTCGTGACAAGAC
CATTAAATTATGGGAAGTATCTACTGGATACTGTGTCCAGACGTTTGAAG
GACATAGCGATTGGGTGCGTGTTGTCAAACCAAATTTTGACGGGTCTCTC
ATAGCATCATGCTCGAATGATAATTCCGTCCGCGTGTGGTCTATGGCCAA
TAAAGAGTGCAAATTCGACTTTCGTGAGCATGAGCATGTAGTGCAGTGTA
TCGTATGGGGTGGACAAAAAATTCACATGGAAACCAATCAGGCTTTATTG
GATGACAAACAGATGACCTCCAATGGGGATTCGTCTAATAAATTGGATGG
TTATAAAATGAGTGGCTGCCATTTACTTGCATCAGGTTCTCGTGATAGAA
CGATTAGGTTGTGGGATACTAATACGGGCGTTTGCCTTTTCAATTTAATT
GGCCACAATAATTGGGTTCAAGAGCTTGTATTTCATCCACAGGGAAAATT
TCTTCTCAGTGCATCAGACGATAAGACTATACGCATATGGGATTTAAAAA
ATCGACGATGCCAAAAAACATTGGAAGCACATGATCATTTTGTTACAACG
ATAGATTTTCATCGCAATTCTCCCTATGTGGTAACTGGAAGTGTCGATCA
GATTGTTAAAGTTTGGGAGTGCCGCTAGTCTCAGATCAATAATTGAAACA
ACACTTAATGAACTTCATTAAATATTCTAACCTCTGTGCTATAAAAATTG
TCTTACATCTCTGAAGTCAAGACATTTAAATTTGAAACGTCTCGAGTATA
ACTCAAAATTATAATGCAGTGGCAATAATTATCTTTCATTTATGTTGAGT
TGAATATTTTAAGCAAATATTTTATTTTGCTAAATAAGATTTCAAATAGA
AATATTGTGTGAATTTTCAGTTAAATATGTTAATATAATTGTCTAATTTT
TA

protein sequence of SMED30016141-orf-1

>SMED30016141-orf-1 ID=SMED30016141-orf-1|Name=SMED30016141-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=426bp
MVLSERQIEELNKSIAEYLIDNGYKETYAIFKGEAKILGEIDKKFSGLLE
KKWTSVIRLQKKVNDLESQLQETKKETHDVISNATFKGRKSSSVDWLPRI
PARHVLKGHRASITCVRFHPLYNVFVSGSEDATIKIWDYESGDYERTLRG
HTNHVQDLAFDPSGKLLASCSADMQIKLWDFVEFTCVKTLSGHDHNVSGV
SFMPSGDHLLSASRDKTIKLWEVSTGYCVQTFEGHSDWVRVVKPNFDGSL
IASCSNDNSVRVWSMANKECKFDFREHEHVVQCIVWGGQKIHMETNQALL
DDKQMTSNGDSSNKLDGYKMSGCHLLASGSRDRTIRLWDTNTGVCLFNLI
GHNNWVQELVFHPQGKFLLSASDDKTIRIWDLKNRRCQKTLEAHDHFVTT
IDFHRNSPYVVTGSVDQIVKVWECR*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000499	cell
PLANA:0000016	pharynx
PLANA:0000026	gut
PLANA:0000103	central nervous system
PLANA:0000429	neoblast
PLANA:0002142	parenchyma

Vocabulary: **biological process**
Term	Definition
GO:0051012	microtubule sliding
GO:0000132	establishment of mitotic spindle orientation
GO:0007017	microtubule-based process
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0051301	cell division
GO:0006810	transport

Vocabulary: **molecular function**
Term	Definition
GO:0070840	dynein complex binding
GO:0005515	protein binding

Vocabulary: **INTERPRO**
Term	Definition
IPR037190	LIS1_N
IPR036322	WD40_repeat_dom_sf
IPR020472	G-protein_beta_WD-40_rep
IPR001680	WD40_repeat
IPR017252	Dynein_regulator_LIS1
IPR006594	LisH
IPR015943	WD40/YVTN_repeat-like_dom_sf
IPR019775	WD40_repeat_CS
IPR017986	WD40_repeat_dom

Vocabulary: **cellular component**
Term	Definition
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005875	microtubule associated complex

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 56..83
None	No IPR available	GENE3D	G3DSA:1.20.960.30		coord: 1..82 e-value: 3.1E-27 score: 96.3
None	No IPR available	PANTHER	PTHR44129:SF6	PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT ALPHA	coord: 1..425
None	No IPR available	PANTHER	PTHR44129	FAMILY NOT NAMED	coord: 1..425
None	No IPR available	CDD	cd00200	WD40	coord: 103..423 e-value: 5.35069E-102 score: 303.102
IPR020472	G-protein beta WD-40 repeat	PRINTS	PR00320	GPROTEINBRPT	coord: 368..382 score: 40.56 coord: 125..139 score: 40.77 coord: 326..340 score: 45.83
IPR006594	LIS1 homology motif	SMART	SM00667	Lish	coord: 7..39 e-value: 0.0021 score: 27.3
IPR006594	LIS1 homology motif	PFAM	PF08513	LisH	coord: 9..35 e-value: 1.2E-4 score: 21.9
IPR006594	LIS1 homology motif	PROSITE	PS50896	LISH	coord: 7..39 score: 9.359
IPR001680	WD40 repeat	SMART	SM00320	WD40_4	coord: 225..264 e-value: 7.8E-10 score: 48.7 coord: 99..138 e-value: 8.7E-10 score: 48.5 coord: 384..423 e-value: 8.6E-9 score: 45.2 coord: 183..222 e-value: 1.1E-10 score: 51.4 coord: 141..180 e-value: 8.6E-11 score: 51.9 coord: 342..381 e-value: 1.4E-10 score: 51.1 coord: 267..339 e-value: 2.3E-4 score: 30.5
IPR001680	WD40 repeat	PFAM	PF00400	WD40	coord: 227..264 e-value: 4.4E-7 score: 30.5 coord: 185..221 e-value: 1.2E-8 score: 35.5 coord: 324..339 e-value: 0.0073 score: 17.1 coord: 344..381 e-value: 2.5E-9 score: 37.6 coord: 386..422 e-value: 3.0E-8 score: 34.2 coord: 104..138 e-value: 1.7E-8 score: 35.0 coord: 144..180 e-value: 1.9E-9 score: 38.0
IPR001680	WD40 repeat	PROSITE	PS50082	WD_REPEATS_2	coord: 349..390 score: 17.393
IPR001680	WD40 repeat	PROSITE	PS50082	WD_REPEATS_2	coord: 190..231 score: 17.259
IPR001680	WD40 repeat	PROSITE	PS50082	WD_REPEATS_2	coord: 106..147 score: 17.359
IPR001680	WD40 repeat	PROSITE	PS50082	WD_REPEATS_2	coord: 391..425 score: 14.652
IPR001680	WD40 repeat	PROSITE	PS50082	WD_REPEATS_2	coord: 232..273 score: 12.915
IPR001680	WD40 repeat	PROSITE	PS50082	WD_REPEATS_2	coord: 148..189 score: 15.755
IPR001680	WD40 repeat	PROSITE	PS50082	WD_REPEATS_2	coord: 325..348 score: 10.275
IPR015943	WD40/YVTN repeat-like-containing domain superfamily	GENE3D	G3DSA:2.130.10.10		coord: 103..425 e-value: 2.1E-127 score: 426.2
IPR017252	Dynein regulator LIS1	PIRSF	PIRSF037647	LisH	coord: 1..424 e-value: 2.4E-156 score: 518.4
IPR019775	WD40 repeat, conserved site	PROSITE	PS00678	WD_REPEATS_1	coord: 368..382
IPR019775	WD40 repeat, conserved site	PROSITE	PS00678	WD_REPEATS_1	coord: 167..181
IPR019775	WD40 repeat, conserved site	PROSITE	PS00678	WD_REPEATS_1	coord: 410..424
IPR019775	WD40 repeat, conserved site	PROSITE	PS00678	WD_REPEATS_1	coord: 326..340
IPR019775	WD40 repeat, conserved site	PROSITE	PS00678	WD_REPEATS_1	coord: 209..223
IPR017986	WD40-repeat-containing domain	PROSITE	PS50294	WD_REPEATS_REGION	coord: 106..425 score: 71.553
IPR037190	LIS1, N-terminal	SUPERFAMILY	SSF109925	Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	coord: 2..73
IPR036322	WD40-repeat-containing domain superfamily	SUPERFAMILY	SSF50978	WD40 repeat-like	coord: 97..422