DthoxE protein

Overview


Name	DthoxE protein
Smed ID	SMED30016117
Length (bp)	1121

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of DthoxE protein (SMED30016117) t-SNE clustered cells

Violin plots show distribution of expression levels for DthoxE protein (SMED30016117) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DthoxE protein (SMED30016117) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DthoxE protein (SMED30016117) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30016117

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
central nervous system	SMED30016117	SMESG000079807.1	SmedASXL_002885	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
central nervous system	SMED30016117	SMESG000079807.1	SmedASXL_002885	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
parenchymal cell	SMED30016117	SMESG000079807.1	SmedASXL_002885	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
parenchymal cell	SMED30016117	SMESG000079807.1	SmedASXL_002885	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
central nervous system	SMED30016117	SMESG000079807.1	Smed-lox5b	smed_ncbi_20200123	PMID:27034770 Currie et al., 2016
parenchymal cell	SMED30016117	SMESG000079807.1	Smed-lox5b	smed_ncbi_20200123	PMID:27034770 Currie et al., 2016
reproductive organ	SMED30016117	SMESG000079807.1	Contig6820	newmark_ests	PMID:28434803 Rouhana et al., 2017
reproductive organ	SMED30016117	SMESG000079807.1	Contig6820	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of DthoxE protein vs. Ensembl Human
Match: HOXB7 (homeobox B7 [Source:HGNC Symbol;Acc:HGNC:5118])

HSP 1 Score: 134.035 bits (336), Expect = 9.556e-37
Identity = 63/86 (73.26%), Postives = 69/86 (80.23%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            +YPWM       S +D KR RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAH L LTERQIKIWFQNRRMKWKK++   K  GPGT
Sbjct:  126 IYPWMR-----SSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKEN---KTAGPGT 203

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BLAST of DthoxE protein vs. Ensembl Human
Match: HOXA7 (homeobox A7 [Source:HGNC Symbol;Acc:HGNC:5108])

HSP 1 Score: 132.109 bits (331), Expect = 6.475e-36
Identity = 64/84 (76.19%), Postives = 67/84 (79.76%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGP 907
            +YPWM       S  D KR RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+H   K  GP
Sbjct:  119 IYPWMR-----SSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEH---KDEGP 194

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BLAST of DthoxE protein vs. Ensembl Human
Match: HOXB6 (homeobox B6 [Source:HGNC Symbol;Acc:HGNC:5117])

HSP 1 Score: 128.642 bits (322), Expect = 1.204e-34
Identity = 62/82 (75.61%), Postives = 69/82 (84.15%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSD----HKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            VYPWM  +MNS +SS      +R RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+  +
Sbjct:  127 VYPWMQ-RMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKL 207

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Query:  656 VYPWMNPKMNSESSSD----HKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            VYPWM  +MNS +SS      +R RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+  +
Sbjct:  127 VYPWMQ-RMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKL 207

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BLAST of DthoxE protein vs. Ensembl Human
Match: HOXC6 (homeobox C6 [Source:HGNC Symbol;Acc:HGNC:5128])

HSP 1 Score: 125.176 bits (313), Expect = 3.427e-34
Identity = 60/81 (74.07%), Postives = 68/81 (83.95%), Query Frame = 2

Query:  656 VYPWMNPKMNSESS----SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHN 886
            +YPWM  +MNS S     +D +R RQ Y+RYQTLELEKEFHFN+YLTRRRRIEIA+AL LTERQIKIWFQNRRMKWKK+ N
Sbjct:   40 IYPWM-QRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESN 119

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BLAST of DthoxE protein vs. Ensembl Celegans
Match: mab-5 (Homeobox protein mab-5 [Source:UniProtKB/Swiss-Prot;Acc:P10038])

HSP 1 Score: 106.301 bits (264), Expect = 5.512e-27
Identity = 50/75 (66.67%), Postives = 60/75 (80.00%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            V+PWM  KM      + KR+RQTY+R QTLELEKEFH++KYLTR+RR EI+  L LTERQ+KIWFQNRRMK KK+
Sbjct:  103 VFPWM--KMGGAKGGESKRTRQTYSRSQTLELEKEFHYHKYLTRKRRQEISETLHLTERQVKIWFQNRRMKHKKE 175

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BLAST of DthoxE protein vs. Ensembl Celegans
Match: lin-39 (Homeobox protein lin-39 [Source:UniProtKB/Swiss-Prot;Acc:P34684])

HSP 1 Score: 104.76 bits (260), Expect = 7.082e-26
Identity = 51/86 (59.30%), Postives = 61/86 (70.93%), Query Frame = 2

Query:  653 VVYPWMNPKMNSESSS-DHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGP 907
             VYPWM    ++   S   KR R  YTR Q LELEKEFH +KYLTR+RRIE+AH+L LTERQ+KIWFQNRRMK KK++    +  P
Sbjct:  147 AVYPWMTRVHSTTGGSRGEKRQRTAYTRNQVLELEKEFHTHKYLTRKRRIEVAHSLMLTERQVKIWFQNRRMKHKKENKDKPMTPP 232

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Query:  653 VVYPWMNPKMNSESSS-DHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGP 907
             VYPWM    ++   S   KR R  YTR Q LELEKEFH +KYLTR+RRIE+AH+L LTERQ+KIWFQNRRMK KK++    +  P
Sbjct:  147 AVYPWMTRVHSTTGGSRGEKRQRTAYTRNQVLELEKEFHTHKYLTRKRRIEVAHSLMLTERQVKIWFQNRRMKHKKENKDKPMTPP 232

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BLAST of DthoxE protein vs. Ensembl Celegans
Match: php-3 (Posterior Hox gene Paralog [Source:UniProtKB/TrEMBL;Acc:Q9XW88])

HSP 1 Score: 80.1073 bits (196), Expect = 8.263e-17
Identity = 37/64 (57.81%), Postives = 50/64 (78.12%), Query Frame = 2

Query:  686 SESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKK 877
            + SS   ++ R+ YT+ QTLELEKEF +N Y+++++R E+A  L LTERQ+KIWFQNRRMK KK
Sbjct:  193 TSSSHAMRKKRKPYTKAQTLELEKEFLYNTYVSKQKRWELAKYLHLTERQVKIWFQNRRMKDKK 256

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Query:  686 SESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKK 877
            + SS   ++ R+ YT+ QTLELEKEF +N Y+++++R E+A  L LTERQ+KIWFQNRRMK KK
Sbjct:  193 TSSSHAMRKKRKPYTKAQTLELEKEFLYNTYVSKQKRWELAKYLHLTERQVKIWFQNRRMKDKK 256

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BLAST of DthoxE protein vs. Ensembl Fly
Match: Antp (gene:FBgn0260642 transcript:FBtr0081649)

HSP 1 Score: 127.102 bits (318), Expect = 4.119e-33
Identity = 59/75 (78.67%), Postives = 63/75 (84.00%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            +YPWM       S  + KR RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+
Sbjct:  270 LYPWM------RSQFERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 338

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BLAST of DthoxE protein vs. Ensembl Fly
Match: Antp (gene:FBgn0260642 transcript:FBtr0081656)

HSP 1 Score: 127.102 bits (318), Expect = 4.119e-33
Identity = 59/75 (78.67%), Postives = 63/75 (84.00%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            +YPWM       S  + KR RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+
Sbjct:  270 LYPWM------RSQFERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 338

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BLAST of DthoxE protein vs. Ensembl Fly
Match: Antp (gene:FBgn0260642 transcript:FBtr0081648)

HSP 1 Score: 127.487 bits (319), Expect = 4.880e-33
Identity = 59/75 (78.67%), Postives = 63/75 (84.00%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            +YPWM       S  + KR RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+
Sbjct:  283 LYPWM------RSQFERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 351

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BLAST of DthoxE protein vs. Ensembl Fly
Match: Antp (gene:FBgn0260642 transcript:FBtr0081651)

HSP 1 Score: 127.487 bits (319), Expect = 4.880e-33
Identity = 59/75 (78.67%), Postives = 63/75 (84.00%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            +YPWM       S  + KR RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+
Sbjct:  283 LYPWM------RSQFERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 351

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BLAST of DthoxE protein vs. Ensembl Fly
Match: Antp (gene:FBgn0260642 transcript:FBtr0081653)

HSP 1 Score: 127.102 bits (318), Expect = 4.953e-33
Identity = 58/75 (77.33%), Postives = 63/75 (84.00%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            +YPWM  +       + KR RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+
Sbjct:  270 LYPWMRSQFGK--CQERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 342

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BLAST of DthoxE protein vs. Ensembl Zebrafish
Match: hoxc6a (homeobox C6a [Source:NCBI gene;Acc:30346])

HSP 1 Score: 128.642 bits (322), Expect = 5.430e-35
Identity = 64/97 (65.98%), Postives = 74/97 (76.29%), Query Frame = 2

Query:  647 DMVVYPWMNPKMNSESS----SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHN----IPKLNGPGT 913
            ++ +YPWM  +MNS S     SD +R RQ Y+RYQTLELEKEFHFN+YLTRRRRIEIA+AL LTERQIKIWFQNRRMKWKK+ N    +P     GT
Sbjct:   97 NIQIYPWMQ-RMNSHSGVGYGSDRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKETNLTSTVPGTESAGT 192

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BLAST of DthoxE protein vs. Ensembl Zebrafish
Match: hoxb7a (homeobox B7a [Source:NCBI gene;Acc:58044])

HSP 1 Score: 127.872 bits (320), Expect = 1.585e-34
Identity = 57/78 (73.08%), Postives = 66/78 (84.62%), Query Frame = 2

Query:  647 DMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            ++ +YPWM       + +D KR RQTY+RYQTLELEKEFHFN+YL+RRRRIEIAHAL LTERQIKIWFQNRRMKWKK+
Sbjct:  131 NLRIYPWMRS-----TGADRKRGRQTYSRYQTLELEKEFHFNRYLSRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 203

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BLAST of DthoxE protein vs. Ensembl Zebrafish
Match: hoxb6a (homeobox B6a [Source:NCBI gene;Acc:30341])

HSP 1 Score: 127.872 bits (320), Expect = 1.863e-34
Identity = 61/81 (75.31%), Postives = 69/81 (85.19%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSS---DHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            VYPWM  +MNS + +     +R RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK++ +
Sbjct:  132 VYPWMQ-RMNSCNGTFGNAGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKL 211

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BLAST of DthoxE protein vs. Ensembl Zebrafish
Match: hoxb6b (homeobox B6b [Source:NCBI gene;Acc:58053])

HSP 1 Score: 125.946 bits (315), Expect = 8.396e-34
Identity = 60/79 (75.95%), Postives = 68/79 (86.08%), Query Frame = 2

Query:  656 VYPWMNPKMNSESS---SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDH 883
            VYPWM  +MNS +    S  +R RQTYTR+QTLELEKEFHFN+YLTRRRRIEI+HAL LTERQIKIWFQNRRMKWKK++
Sbjct:  129 VYPWMQ-RMNSCNGMPGSTGRRGRQTYTRFQTLELEKEFHFNRYLTRRRRIEISHALCLTERQIKIWFQNRRMKWKKEN 206

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Query:  656 VYPWMNPKMNSESS---SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDH 883
            VYPWM  +MNS +    S  +R RQTYTR+QTLELEKEFHFN+YLTRRRRIEI+HAL LTERQIKIWFQNRRMKWKK++
Sbjct:  129 VYPWMQ-RMNSCNGMPGSTGRRGRQTYTRFQTLELEKEFHFNRYLTRRRRIEISHALCLTERQIKIWFQNRRMKWKKEN 206

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BLAST of DthoxE protein vs. Ensembl Xenopus
Match: cd276 (CD276 molecule [Source:Xenbase;Acc:XB-GENE-921537])

HSP 1 Score: 130.954 bits (328), Expect = 8.939e-36
Identity = 61/76 (80.26%), Postives = 64/76 (84.21%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDH 883
            +YPWM       S  D KR RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+H
Sbjct:  110 IYPWMR-----SSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEH 180

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BLAST of DthoxE protein vs. Ensembl Xenopus
Match: HOXB7 (homeobox B7 [Source:NCBI gene;Acc:100494663])

HSP 1 Score: 130.568 bits (327), Expect = 1.950e-35
Identity = 59/79 (74.68%), Postives = 67/79 (84.81%), Query Frame = 2

Query:  647 DMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDH 883
            ++ +YPWM       + +D KR RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK++
Sbjct:  122 NLRIYPWMR-----STGADRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN 195

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BLAST of DthoxE protein vs. Ensembl Xenopus
Match: zdhhc15 (zinc finger DHHC-type containing 15 [Source:Xenbase;Acc:XB-GENE-948859])

HSP 1 Score: 129.798 bits (325), Expect = 6.196e-35
Identity = 62/90 (68.89%), Postives = 71/90 (78.89%), Query Frame = 2

Query:  656 VYPWMNPKMNSESS----SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            +YPWM  +MNS S     +D +R RQ Y+RYQTLELEKEFHFN+YLTRRRRIEIA+AL LTERQIKIWFQNRRMKWKK+ N+      GT
Sbjct:  122 IYPWMQ-RMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGT 210

[Close]

BLAST of DthoxE protein vs. Ensembl Xenopus
Match: HOXB6 (homeobox B6 [Source:NCBI gene;Acc:100124320])

HSP 1 Score: 127.872 bits (320), Expect = 2.379e-34
Identity = 62/82 (75.61%), Postives = 69/82 (84.15%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSS----DHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            VYPWM  +MNS +SS      +R RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAH+L LTERQIKIWFQNRRMKWKK+  +
Sbjct:  126 VYPWMQ-RMNSCNSSVFGPSGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHSLCLTERQIKIWFQNRRMKWKKESKL 206

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BLAST of DthoxE protein vs. Ensembl Xenopus
Match: ppm1j (protein phosphatase, Mg2+/Mn2+ dependent 1J [Source:Xenbase;Acc:XB-GENE-941439])

HSP 1 Score: 127.102 bits (318), Expect = 9.605e-34
Identity = 60/87 (68.97%), Postives = 67/87 (77.01%), Query Frame = 2

Query:  647 DMVVYPWMNPKMNSESSS-----DHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIP 892
            D VVYPWM     S +SS     + KRSR  YTR Q LELEKEFH+N+YLTRRRR+EIAH L L+ERQIKIWFQNRRMKWKKDH +P
Sbjct:  146 DPVVYPWMKKAHISRASSTYSDGEAKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHTLRLSERQIKIWFQNRRMKWKKDHKLP 232

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BLAST of DthoxE protein vs. Ensembl Mouse
Match: Hoxb7 (homeobox B7 [Source:MGI Symbol;Acc:MGI:96188])

HSP 1 Score: 133.265 bits (334), Expect = 1.299e-36
Identity = 63/86 (73.26%), Postives = 69/86 (80.23%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            +YPWM       S  D KR RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAH L LTERQIKIWFQNRRMKWKK++   K +GPGT
Sbjct:  126 IYPWMR-----SSGPDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKEN---KTSGPGT 203

[Close]

BLAST of DthoxE protein vs. Ensembl Mouse
Match: Hoxa7 (homeobox A7 [Source:MGI Symbol;Acc:MGI:96179])

HSP 1 Score: 133.265 bits (334), Expect = 1.614e-36
Identity = 61/76 (80.26%), Postives = 64/76 (84.21%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDH 883
            +YPWM       S  D KR RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+H
Sbjct:  118 IYPWMR-----SSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEH 188

[Close]

BLAST of DthoxE protein vs. Ensembl Mouse
Match: Hoxb6 (homeobox B6 [Source:MGI Symbol;Acc:MGI:96187])

HSP 1 Score: 129.028 bits (323), Expect = 5.973e-35
Identity = 70/127 (55.12%), Postives = 82/127 (64.57%), Query Frame = 2

Query:  530 NNAICQHLGSN---LFHDQHFKSDIPSLXXXXXXXXXXXXXXDMVVYPWMNPKMNSESSSD----HKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
             +A C   G++    FH +  KSD       +             VYPWM  +MNS +SS      +R RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+  +
Sbjct:   84 KDAACALSGADEPPPFHPEPRKSDC--AQDKSVFGETEEQKCSTPVYPWMQ-RMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKL 207

[Close]

Query:  530 NNAICQHLGSN---LFHDQHFKSDIPSLXXXXXXXXXXXXXXDMVVYPWMNPKMNSESSSD----HKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
             +A C   G++    FH +  KSD       +             VYPWM  +MNS +SS      +R RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK+  +
Sbjct:   84 KDAACALSGADEPPPFHPEPRKSDC--AQDKSVFGETEEQKCSTPVYPWMQ-RMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKL 207

[Close]

BLAST of DthoxE protein vs. Ensembl Mouse
Match: Hoxc6 (homeobox C6 [Source:MGI Symbol;Acc:MGI:96197])

HSP 1 Score: 126.331 bits (316), Expect = 8.976e-34
Identity = 60/81 (74.07%), Postives = 68/81 (83.95%), Query Frame = 2

Query:  656 VYPWMNPKMNSESS----SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHN 886
            +YPWM  +MNS S     +D +R RQ Y+RYQTLELEKEFHFN+YLTRRRRIEIA+AL LTERQIKIWFQNRRMKWKK+ N
Sbjct:  122 IYPWMQ-RMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESN 201

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BLAST of DthoxE protein vs. UniProt/SwissProt
Match: sp|Q9TT89|HXB7_BOVIN (Homeobox protein Hox-B7 OS=Bos taurus OX=9913 GN=HOXB7 PE=2 SV=1)

HSP 1 Score: 136.732 bits (343), Expect = 4.626e-37
Identity = 64/86 (74.42%), Postives = 71/86 (82.56%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            +YPWM       S +D KR RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK++   K +GPGT
Sbjct:  126 IYPWMR-----SSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN---KTSGPGT 203

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BLAST of DthoxE protein vs. UniProt/SwissProt
Match: sp|A1YFA5|HXB7_GORGO (Homeobox protein Hox-B7 OS=Gorilla gorilla gorilla OX=9595 GN=HOXB7 PE=3 SV=1)

HSP 1 Score: 136.346 bits (342), Expect = 5.771e-37
Identity = 64/86 (74.42%), Postives = 70/86 (81.40%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            +YPWM       S +D KR RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK++   K  GPGT
Sbjct:  126 IYPWMR-----SSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN---KTAGPGT 203

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BLAST of DthoxE protein vs. UniProt/SwissProt
Match: sp|P18864|HXB7_RAT (Homeobox protein Hox-B7 OS=Rattus norvegicus OX=10116 GN=Hoxb7 PE=2 SV=2)

HSP 1 Score: 134.806 bits (338), Expect = 2.775e-36
Identity = 63/86 (73.26%), Postives = 71/86 (82.56%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            +YPWM       S ++ KR RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK++   K +GPGT
Sbjct:  126 IYPWMR-----SSGTERKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN---KTSGPGT 203

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BLAST of DthoxE protein vs. UniProt/SwissProt
Match: sp|P09629|HXB7_HUMAN (Homeobox protein Hox-B7 OS=Homo sapiens OX=9606 GN=HOXB7 PE=1 SV=4)

HSP 1 Score: 134.035 bits (336), Expect = 4.589e-36
Identity = 63/86 (73.26%), Postives = 69/86 (80.23%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            +YPWM       S +D KR RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAH L LTERQIKIWFQNRRMKWKK++   K  GPGT
Sbjct:  126 IYPWMR-----SSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKEN---KTAGPGT 203

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BLAST of DthoxE protein vs. UniProt/SwissProt
Match: sp|P09024|HXB7_MOUSE (Homeobox protein Hox-B7 OS=Mus musculus OX=10090 GN=Hoxb7 PE=2 SV=2)

HSP 1 Score: 133.265 bits (334), Expect = 9.089e-36
Identity = 63/86 (73.26%), Postives = 69/86 (80.23%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            +YPWM       S  D KR RQTYTRYQTLELEKEFH+N+YLTRRRRIEIAH L LTERQIKIWFQNRRMKWKK++   K +GPGT
Sbjct:  126 IYPWMR-----SSGPDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKEN---KTSGPGT 203

[Close]

BLAST of DthoxE protein vs. TrEMBL
Match: O76939 (DthoxE protein OS=Girardia tigrina OX=6162 GN=DthoxE PE=3 SV=1)

HSP 1 Score: 412.92 bits (1060), Expect = 5.369e-141
Identity = 268/329 (81.46%), Postives = 293/329 (89.06%), Query Frame = 2

Query:   59 MKLMYPNYHSVMPEFQLNCESEISSNTT-----IGYDHPVSIXXXXXXXXXXXXXXXXXXXXXXXGLELPPNFSIPRYSDEFLLTGN-QDSSKSLPNYSQQSCYYLYRKPSRTETQNLNLPYSGAWKNSSLFCHGTINSNYETDS-----XXXXXXXXXXISHIRALGNNAICQHLGSNLFHDQHFKSDIPSLXXXXXXXXXXXXXXDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTXXXXXXXXXXXXXXXXXXXTDIEDHCSDTESLN 1012
            MKLMYPNYHSVMPEFQL+CE+EISSNTT     I YDH  S+T++SYNSMKN   FT+PS+LNNS LEL PNFSIPRYS+EFLL G+ QDSSK++PNY+QQ CYYLYRK  R+ET +LNLPY  +WKNS++FCHG+IN+NYETDS     N+  NN NNNI+HIRAL NNAICQHLG+NLFH+ HFKSD+ SLHSPNNIINNSPNHNDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKL+ KTD EDHCSD ES N
Sbjct:    1 MKLMYPNYHSVMPEFQLSCETEISSNTTLASGAIDYDHSTSLTDTSYNSMKNQPVFTTPSSLNNSCLELAPNFSIPRYSEEFLLPGDHQDSSKNIPNYNQQPCYYLYRKQPRSETHDLNLPYP-SWKNSNIFCHGSINNNYETDSLLHPNNSNNNNTNNNITHIRALSNNAICQHLGTNLFHEPHFKSDLQSLHSPNNIINNSPNHNDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKLDIKTDQEDHCSDAESGN 328

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BLAST of DthoxE protein vs. TrEMBL
Match: Q9XY03 (PLOX6-Dj (Fragment) OS=Dugesia japonica OX=6161 GN=Plox6-Dj PE=2 SV=1)

HSP 1 Score: 293.893 bits (751), Expect = 9.511e-96
Identity = 188/216 (87.04%), Postives = 201/216 (93.06%), Query Frame = 2

Query:  380 ETQNLNLPYSGAWKNSSLFCHGTINSNYETDS-------XXXXXXXXXXISHIRALGNNAICQHLGSNLFHDQHFKSDIPSLXXXXXXXXXXXXXXDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTXXXXXXXXXXXXXXXXXXXTDIEDHCSDTES 1006
            ETQ+LNLPY  +WKNS++FCHG+IN+NYE DS       NN ++NN+NN ++IRAL NNAICQHLGSNLFH+ HFKSD+PSLHSPNNIINNSPNHNDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKLEAKTDIEDHCSD ES
Sbjct:    1 ETQDLNLPYP-SWKNSNIFCHGSINTNYENDSLINSNNNNNNSSNNSNNSNNIRALSNNAICQHLGSNLFHEPHFKSDLPSLHSPNNIINNSPNHNDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKLEAKTDIEDHCSDNES 215

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BLAST of DthoxE protein vs. TrEMBL
Match: Q24681 (DNA-binding protein (Fragment) OS=Girardia tigrina OX=6162 GN=homeobox PE=2 SV=1)

HSP 1 Score: 283.108 bits (723), Expect = 8.466e-92
Identity = 160/191 (83.77%), Postives = 174/191 (91.10%), Query Frame = 2

Query:  353 YLYRKPSRTETQNLNLPYSGAWKNSSLFCHGTINSNYETDS-----XXXXXXXXXXISHIRALGNNAICQHLGSNLFHDQHFKSDIPSLXXXXXXXXXXXXXXDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPG 910
            YLYRK  R+ET +LNLPY  +WKNS++FCHG+IN+NYETDS     N+  N+ NNNI+HIRAL NNAICQHLG+NLFH+ HFKSD+ SLHSPNNIINNSPNHNDMVVYPW+NPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAH LSLTERQIKIWFQNRRMKWKKDHNIPKLNGPG
Sbjct:    1 YLYRKRPRSETHDLNLPYP-SWKNSNIFCHGSINNNYETDSLLHPNNSNNNSTNNNITHIRALSNNAICQHLGTNLFHEPHFKSDLQSLHSPNNIINNSPNHNDMVVYPWLNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHGLSLTERQIKIWFQNRRMKWKKDHNIPKLNGPG 190

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BLAST of DthoxE protein vs. TrEMBL
Match: A0A1S6KMI5 (Homeobox domain-containing protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 215.312 bits (547), Expect = 2.975e-66
Identity = 122/122 (100.00%), Postives = 122/122 (100.00%), Query Frame = 2

Query:  650 MVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTXXXXXXXXXXXXXXXXXXXTDIEDHCSDTESLNT 1015
            MVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKLEAKTDIEDHCSDTESLNT
Sbjct:    1 MVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKLEAKTDIEDHCSDTESLNT 122

[Close]

BLAST of DthoxE protein vs. TrEMBL
Match: A0A094ZDF2 (Homeobox protein SMOX-1 (Fragment) OS=Schistosoma haematobium OX=6185 GN=MS3_00445 PE=3 SV=1)

HSP 1 Score: 166.007 bits (419), Expect = 1.444e-44
Identity = 76/89 (85.39%), Postives = 82/89 (92.13%), Query Frame = 2

Query:  647 DMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            ++VVYPWMNPK  ++ S D KR+RQTYTRYQTLELEKEFHFNKYLTRRRRIEIAH L+LTERQIKIWFQNRRMKWKKDHNI KLNGPGT
Sbjct:   41 NVVVYPWMNPK-GTDISVDQKRTRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHTLTLTERQIKIWFQNRRMKWKKDHNIAKLNGPGT 128

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BLAST of DthoxE protein vs. Ensembl Cavefish
Match: hoxb7a (homeobox B7 [Source:NCBI gene;Acc:103045369])

HSP 1 Score: 130.183 bits (326), Expect = 2.151e-35
Identity = 59/89 (66.29%), Postives = 69/89 (77.53%), Query Frame = 2

Query:  647 DMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            ++ +YPWM       + +D KR RQTY+RYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK++     + P  
Sbjct:  133 NLRIYPWMR-----STGADRKRGRQTYSRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTAHPSSPAA 216

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BLAST of DthoxE protein vs. Ensembl Cavefish
Match: hoxc6a (homeobox C6 [Source:NCBI gene;Acc:103034651])

HSP 1 Score: 128.257 bits (321), Expect = 1.208e-34
Identity = 61/85 (71.76%), Postives = 71/85 (83.53%), Query Frame = 2

Query:  647 DMVVYPWMNPKMNSESS----SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            ++ +YPWM  +MNS S     SD +R RQ Y+RYQTLELEKEFHFN+YLTRRRRIEIA+AL LTERQIKIWFQNRRMKWKK+ N+
Sbjct:  119 NIQIYPWMQ-RMNSHSGVGYGSDRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNL 202

[Close]

BLAST of DthoxE protein vs. Ensembl Cavefish
Match: hoxb6a (homeobox protein Hox-B6a [Source:NCBI gene;Acc:103045875])

HSP 1 Score: 127.102 bits (318), Expect = 2.866e-34
Identity = 61/81 (75.31%), Postives = 69/81 (85.19%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSS---DHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            VYPWM  +MNS + +     +R RQTYTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKK++ +
Sbjct:  130 VYPWMQ-RMNSCNGTFGNPGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKL 209

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BLAST of DthoxE protein vs. Ensembl Cavefish
Match: hoxb6b (homeobox protein Hox-B6b [Source:NCBI gene;Acc:103030519])

HSP 1 Score: 125.561 bits (314), Expect = 8.406e-34
Identity = 59/81 (72.84%), Postives = 69/81 (85.19%), Query Frame = 2

Query:  656 VYPWMNPKMNSESS---SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            VYPWM  +MNS +    +  +R RQTYTR+QTLELEKEFHFN+YLTRRRRIEI+HAL LTERQIKIWFQNRRMKWKK++ +
Sbjct:  121 VYPWMQ-RMNSCNGIPGNTGRRGRQTYTRFQTLELEKEFHFNRYLTRRRRIEISHALCLTERQIKIWFQNRRMKWKKENKV 200

[Close]

BLAST of DthoxE protein vs. Ensembl Cavefish
Match: hoxb5b (homeobox protein Hox-B5b [Source:NCBI gene;Acc:103029979])

HSP 1 Score: 126.331 bits (316), Expect = 2.300e-33
Identity = 58/83 (69.88%), Postives = 66/83 (79.52%), Query Frame = 2

Query:  656 VYPWMNPKMNSE--SSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKL 898
            ++PWM     S   +  D KR+R  YTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKKD+ +  +
Sbjct:  188 IFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKDNKLKSM 270

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BLAST of DthoxE protein vs. Ensembl Sea Lamprey
Match: hoxb7a (homeobox B7a [Source:NCBI gene;Acc:58044])

HSP 1 Score: 114.005 bits (284), Expect = 6.208e-32
Identity = 53/64 (82.81%), Postives = 59/64 (92.19%), Query Frame = 2

Query:  701 DHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIP 892
            D KR RQTY+RYQTLELEKEFHFN+YLTRRRR+EIAH+L LTERQIKIWFQNRRMKWKK++  P
Sbjct:    3 DGKRGRQTYSRYQTLELEKEFHFNRYLTRRRRVEIAHSLCLTERQIKIWFQNRRMKWKKENRGP 66

[Close]

BLAST of DthoxE protein vs. Ensembl Sea Lamprey
Match: hoxd4a (homeobox D4a [Source:NCBI gene;Acc:30329])

HSP 1 Score: 113.235 bits (282), Expect = 1.695e-31
Identity = 52/64 (81.25%), Postives = 57/64 (89.06%), Query Frame = 2

Query:  701 DHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIP 892
            + KRSR  YTR Q LELEKEFHFN+YLTRRRRIEIAH+L L+ERQIKIWFQNRRMKWKKDH +P
Sbjct:    1 ESKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHKLP 64

[Close]

BLAST of DthoxE protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005057.1 (pep scaffold:Pmarinus_7.0:GL483321:9136:13526:-1 gene:ENSPMAG00000004598.1 transcript:ENSPMAT00000005057.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 111.694 bits (278), Expect = 9.863e-31
Identity = 52/81 (64.20%), Postives = 63/81 (77.78%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKL 898
            V+PWM P+         +R RQTY+RYQTLELEKEF FN YLTR+RRIE++H L L+ERQ+KIWFQNRRMKWKK++N  K 
Sbjct:   16 VFPWMRPQ-----GPARRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHVLGLSERQVKIWFQNRRMKWKKENNRDKF 91

[Close]

BLAST of DthoxE protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011116.1 (pep scaffold:Pmarinus_7.0:GL482944:7995:8174:-1 gene:ENSPMAG00000010089.1 transcript:ENSPMAT00000011116.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 98.9821 bits (245), Expect = 2.182e-26
Identity = 42/58 (72.41%), Postives = 55/58 (94.83%), Query Frame = 2

Query:  707 KRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            ++ R++Y+R+Q+LELEKEFHFN+YL RRRR+EIAH+L L+ERQ+KIWFQNRRMKWKK+
Sbjct:    2 RKGRRSYSRHQSLELEKEFHFNRYLARRRRVEIAHSLCLSERQVKIWFQNRRMKWKKE 59

[Close]

BLAST of DthoxE protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011449.1 (pep scaffold:Pmarinus_7.0:GL493006:3300:3479:1 gene:ENSPMAG00000010422.1 transcript:ENSPMAT00000011449.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 83.5741 bits (205), Expect = 1.022e-20
Identity = 40/57 (70.18%), Postives = 49/57 (85.96%), Query Frame = 2

Query:  707 KRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKK 877
            ++ R  YT++QTLELEKEF F+ YLTR RR+EI+H LSLT+RQ+KIWFQNRRMK KK
Sbjct:    2 RKKRCPYTKHQTLELEKEFLFSMYLTRERRLEISHLLSLTDRQVKIWFQNRRMKLKK 58

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BLAST of DthoxE protein vs. Ensembl Yeast
Match: YOX1 (Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication [Source:SGD;Acc:S000004489])

HSP 1 Score: 46.2098 bits (108), Expect = 4.265e-6
Identity = 25/75 (33.33%), Postives = 42/75 (56.00%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLE-LEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKK 877
             +P   PK+++   +  KR R   T  Q L  L+ EF      ++ +RIE+A +  +TE+ ++IWFQN+R   K+
Sbjct:  162 TFPKKEPKIDNAPLARRKRRR---TSSQELSILQAEFEKCPAPSKEKRIELAESCHMTEKAVQIWFQNKRQAVKR 233

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BLAST of DthoxE protein vs. Ensembl Nematostella
Match: ANTHOX1A.NV (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGM8])

HSP 1 Score: 94.7449 bits (234), Expect = 1.674e-23
Identity = 45/67 (67.16%), Postives = 50/67 (74.63%), Query Frame = 2

Query:  710 RSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHN--IPKLNG 904
            R R  YTR Q LELEKEFHF +YLT+ RR E+A  L LTERQ+KIWFQNRRMKWKKD+   IP   G
Sbjct:   81 RKRMAYTRIQLLELEKEFHFTRYLTKERRTEMARMLDLTERQVKIWFQNRRMKWKKDNKPVIPTSRG 147

[Close]

BLAST of DthoxE protein vs. Ensembl Nematostella
Match: EDO42187 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S274])

HSP 1 Score: 89.3521 bits (220), Expect = 1.329e-22
Identity = 44/58 (75.86%), Postives = 47/58 (81.03%), Query Frame = 2

Query:  707 KRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            KR R +YT  Q LELEKEFHFNKYL   RR EI+ AL LTERQ+KIWFQNRRMKWKKD
Sbjct:    2 KRHRTSYTNKQLLELEKEFHFNKYLCSSRRREISKALQLTERQVKIWFQNRRMKWKKD 59

[Close]

BLAST of DthoxE protein vs. Ensembl Nematostella
Match: ANTHOX7 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S272])

HSP 1 Score: 93.9745 bits (232), Expect = 2.224e-22
Identity = 58/132 (43.94%), Postives = 75/132 (56.82%), Query Frame = 2

Query:  542 CQHLGSNLFHDQH-------FKSDIPSLXXXXXXXXXXXXXXDMVVYPWMNPKMNSE---SSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGP 907
             Q  G+ LF D +       F   I S+   ++   + PN+    +YPWM  K +          KR R +YT  Q LELEKEFH+NKYL   RR E+A+A+ LTERQ+K+WFQNRRMK KKD    K +GP
Sbjct:   35 TQGFGAGLFLDTYTSHIGRDFDGPIGSIPVGSSNRESLPNYLLQPIYPWMRTKKSGSRGIGGKHTKRYRTSYTNRQLLELEKEFHYNKYLCGTRRRELANAMKLTERQVKVWFQNRRMKLKKDEK-QKEDGP 165

[Close]

BLAST of DthoxE protein vs. Ensembl Nematostella
Match: HOX6 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S277])

HSP 1 Score: 92.8189 bits (229), Expect = 1.076e-21
Identity = 43/69 (62.32%), Postives = 54/69 (78.26%), Query Frame = 2

Query:  674 PKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            P+   ++ S  ++ R T+T+ Q +ELEKEFHF+KYLTR RRIEIA  L LTE QIKIWFQNRRMKWK++
Sbjct:  143 PEEKEQNPSPSQKKRFTFTQRQLVELEKEFHFSKYLTRTRRIEIATTLKLTEMQIKIWFQNRRMKWKRE 211

[Close]

BLAST of DthoxE protein vs. Ensembl Nematostella
Match: EDO45896 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRW6])

HSP 1 Score: 84.3445 bits (207), Expect = 8.255e-21
Identity = 38/60 (63.33%), Postives = 50/60 (83.33%), Query Frame = 2

Query:  710 RSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            ++R  Y+  Q +ELEKEFH+N+YL R RRIEIA +L LTE+Q+KIWFQNRRMKWKK++ +
Sbjct:    3 KNRTIYSTRQLVELEKEFHYNRYLCRPRRIEIAQSLELTEKQVKIWFQNRRMKWKKENKL 62

[Close]

BLAST of DthoxE protein vs. Ensembl Medaka
Match: HOXA7 (homeobox A7 [Source:NCBI gene;Acc:110015904])

HSP 1 Score: 129.028 bits (323), Expect = 6.274e-35
Identity = 58/76 (76.32%), Postives = 65/76 (85.53%), Query Frame = 2

Query:  656 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDH 883
            +YPWM       S  + KR RQTY+RYQTLELEKEFHFN+YL+RRRR+EIAHAL+LTERQIKIWFQNRRMKWKKDH
Sbjct:  112 MYPWMQA-----SDPNRKRGRQTYSRYQTLELEKEFHFNRYLSRRRRVEIAHALTLTERQIKIWFQNRRMKWKKDH 182

[Close]

BLAST of DthoxE protein vs. Ensembl Medaka
Match: hoxc6a (homeobox C6 [Source:NCBI gene;Acc:101173938])

HSP 1 Score: 127.487 bits (319), Expect = 2.199e-34
Identity = 60/83 (72.29%), Postives = 70/83 (84.34%), Query Frame = 2

Query:  656 VYPWMNPKMNSESS-----SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            +YPWM  +MNS S+     +D +R RQ Y+RYQTLELEKEFHFN+YLTRRRRIEIA+AL LTERQIKIWFQNRRMKWKK+ N+
Sbjct:  121 IYPWMQ-RMNSHSAGVGYGTDRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNL 202

[Close]

BLAST of DthoxE protein vs. Ensembl Medaka
Match: hoxb6b (homeobox protein Hox-B6b [Source:NCBI gene;Acc:101164012])

HSP 1 Score: 126.331 bits (316), Expect = 8.939e-34
Identity = 59/83 (71.08%), Postives = 71/83 (85.54%), Query Frame = 2

Query:  653 VVYPWMNPKMNSESS----SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNI 889
            ++YPWM  +MN+ S+    +  +R RQTYTRYQTLELEKEFHFN+YLTRRRRIEI+HAL LTERQIKIWFQNRRMKWKK++ +
Sbjct:  153 LIYPWMQ-RMNACSAGPFGTSGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEISHALCLTERQIKIWFQNRRMKWKKENKL 234

[Close]

BLAST of DthoxE protein vs. Ensembl Medaka
Match: ENSORLT00000021320.2 (homeobox protein Hox-B5a [Source:NCBI gene;Acc:101169786])

HSP 1 Score: 127.487 bits (319), Expect = 1.403e-33
Identity = 58/84 (69.05%), Postives = 67/84 (79.76%), Query Frame = 2

Query:  656 VYPWMNPKMNSE--SSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLN 901
            ++PWM     S   +  D KR+R  YTRYQTLELEKEFHFN+YLTRRRRIEIAHAL LTERQIKIWFQNRRMKWKKD+ +  ++
Sbjct:  217 IFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKDNKVKSMS 300

[Close]

BLAST of DthoxE protein vs. Ensembl Medaka
Match: hoxd4a (homeobox D4a [Source:NCBI gene;Acc:30329])

HSP 1 Score: 125.946 bits (315), Expect = 1.681e-33
Identity = 61/89 (68.54%), Postives = 68/89 (76.40%), Query Frame = 2

Query:  653 VVYPWMNP----KMNSE-SSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNG 904
            VVYPWM       +N + + S+ KRSR  YTR Q LELEKEFHFN+YLTRRRRIEIAH L L+ERQIKIWFQNRRMKWKKDH +P   G
Sbjct:  144 VVYPWMKKVHVTTVNPDYTGSEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKG 232

[Close]

BLAST of DthoxE protein vs. Planmine SMEST
Match: SMESG000079807.1 (SMESG000079807.1)

HSP 1 Score: 511.146 bits (1315), Expect = 0.000e+0
Identity = 319/319 (100.00%), Postives = 319/319 (100.00%), Query Frame = 2

Query:   59 MKLMYPNYHSVMPEFQLNCESEISSNTTIGYDHPVSIXXXXXXXXXXXXXXXXXXXXXXXGLELPPNFSIPRYSDEFLLTGNQDSSKSLPNYSQQSCYYLYRKPSRTETQNLNLPYSGAWKNSSLFCHGTINSNYETDSXXXXXXXXXXISHIRALGNNAICQHLGSNLFHDQHFKSDIPSLXXXXXXXXXXXXXXDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTXXXXXXXXXXXXXXXXXXXTDIEDHCSDTESLNT 1015
            MKLMYPNYHSVMPEFQLNCESEISSNTTIGYDHPVSITESSYNSMKNSSSFTSPSTLNNSGLELPPNFSIPRYSDEFLLTGNQDSSKSLPNYSQQSCYYLYRKPSRTETQNLNLPYSGAWKNSSLFCHGTINSNYETDSNNPTNNNNNNISHIRALGNNAICQHLGSNLFHDQHFKSDIPSLHSPNNIINNSPNHNDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKLEAKTDIEDHCSDTESLNT
Sbjct:    1 MKLMYPNYHSVMPEFQLNCESEISSNTTIGYDHPVSITESSYNSMKNSSSFTSPSTLNNSGLELPPNFSIPRYSDEFLLTGNQDSSKSLPNYSQQSCYYLYRKPSRTETQNLNLPYSGAWKNSSLFCHGTINSNYETDSNNPTNNNNNNISHIRALGNNAICQHLGSNLFHDQHFKSDIPSLHSPNNIINNSPNHNDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKLEAKTDIEDHCSDTESLNT 319

[Close]

BLAST of DthoxE protein vs. Planmine SMEST
Match: SMESG000079807.1 (SMESG000079807.1)

HSP 1 Score: 504.597 bits (1298), Expect = 0.000e+0
Identity = 316/316 (100.00%), Postives = 316/316 (100.00%), Query Frame = 2

Query:   68 MYPNYHSVMPEFQLNCESEISSNTTIGYDHPVSIXXXXXXXXXXXXXXXXXXXXXXXGLELPPNFSIPRYSDEFLLTGNQDSSKSLPNYSQQSCYYLYRKPSRTETQNLNLPYSGAWKNSSLFCHGTINSNYETDSXXXXXXXXXXISHIRALGNNAICQHLGSNLFHDQHFKSDIPSLXXXXXXXXXXXXXXDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTXXXXXXXXXXXXXXXXXXXTDIEDHCSDTESLNT 1015
            MYPNYHSVMPEFQLNCESEISSNTTIGYDHPVSITESSYNSMKNSSSFTSPSTLNNSGLELPPNFSIPRYSDEFLLTGNQDSSKSLPNYSQQSCYYLYRKPSRTETQNLNLPYSGAWKNSSLFCHGTINSNYETDSNNPTNNNNNNISHIRALGNNAICQHLGSNLFHDQHFKSDIPSLHSPNNIINNSPNHNDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKLEAKTDIEDHCSDTESLNT
Sbjct:    1 MYPNYHSVMPEFQLNCESEISSNTTIGYDHPVSITESSYNSMKNSSSFTSPSTLNNSGLELPPNFSIPRYSDEFLLTGNQDSSKSLPNYSQQSCYYLYRKPSRTETQNLNLPYSGAWKNSSLFCHGTINSNYETDSNNPTNNNNNNISHIRALGNNAICQHLGSNLFHDQHFKSDIPSLHSPNNIINNSPNHNDMVVYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEKLEAKTDIEDHCSDTESLNT 316

[Close]

BLAST of DthoxE protein vs. Planmine SMEST
Match: SMESG000022667.1 (SMESG000022667.1)

HSP 1 Score: 150.214 bits (378), Expect = 1.066e-42
Identity = 69/91 (75.82%), Postives = 83/91 (91.21%), Query Frame = 2

Query:  647 DMVVYPWMNPKMNSES--SSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGT 913
            ++++Y WMNPK  +++  SS++KR+RQTYTR+QTLELEKEFHFNKYLTRRRRIEIAH+L LTERQIKIWFQNRRMKWKK+HNI KL GPG+
Sbjct:  142 NVMLYSWMNPKSGADNPNSSNNKRTRQTYTRHQTLELEKEFHFNKYLTRRRRIEIAHSLILTERQIKIWFQNRRMKWKKEHNIAKLTGPGS 232

[Close]

BLAST of DthoxE protein vs. Planmine SMEST
Match: SMESG000044469.1 (SMESG000044469.1)

HSP 1 Score: 111.694 bits (278), Expect = 2.951e-29
Identity = 52/82 (63.41%), Postives = 67/82 (81.71%), Query Frame = 2

Query:  647 DMVVYPWMNP----KMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD 880
            +   +PWM      K  S+ S+++KRSRQ Y+R QTLELEKEF++N+YLTRRRRIEIA+++ L+ERQIKIWFQNRRMK+KKD
Sbjct:   82 NFPAFPWMQKSNTRKNKSDRSAEYKRSRQAYSRQQTLELEKEFYYNQYLTRRRRIEIANSVCLSERQIKIWFQNRRMKYKKD 163

[Close]

BLAST of DthoxE protein vs. Planmine SMEST
Match: SMESG000071019.1 (SMESG000071019.1)

HSP 1 Score: 116.316 bits (290), Expect = 3.277e-29
Identity = 51/65 (78.46%), Postives = 58/65 (89.23%), Query Frame = 2

Query:  698 SDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKDHNIP 892
            SD KR+R  YTR Q LELEKEFHFNKYLTR+RRIEIA +L L+ERQ+KIWFQNRRMKWKKDH++P
Sbjct:  223 SDSKRNRTAYTRQQILELEKEFHFNKYLTRKRRIEIAQSLQLSERQVKIWFQNRRMKWKKDHHLP 287

The following BLAST results are available for this feature:

BLAST of DthoxE protein vs. Ensembl Human
BLAST of DthoxE protein vs. Ensembl Celegans
BLAST of DthoxE protein vs. Ensembl Fly
BLAST of DthoxE protein vs. Ensembl Zebrafish
BLAST of DthoxE protein vs. Ensembl Xenopus
BLAST of DthoxE protein vs. Ensembl Mouse
BLAST of DthoxE protein vs. UniProt/SwissProt
BLAST of DthoxE protein vs. TrEMBL
BLAST of DthoxE protein vs. Ensembl Cavefish
BLAST of DthoxE protein vs. Ensembl Sea Lamprey
BLAST of DthoxE protein vs. Ensembl Yeast
BLAST of DthoxE protein vs. Ensembl Nematostella
BLAST of DthoxE protein vs. Ensembl Medaka
BLAST of DthoxE protein vs. Planmine SMEST

BLAST of DthoxE protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HOXB7	9.556e-37	73.26	homeobox B7 [Source:HGNC Symbol;Acc:HGNC:5118]	[more]
HOXA7	6.475e-36	76.19	homeobox A7 [Source:HGNC Symbol;Acc:HGNC:5108]	[more]
HOXB6	1.204e-34	75.61	homeobox B6 [Source:HGNC Symbol;Acc:HGNC:5117]	[more]
HOXB6	1.204e-34	75.61	homeobox B6 [Source:HGNC Symbol;Acc:HGNC:5117]	[more]
HOXC6	3.427e-34	74.07	homeobox C6 [Source:HGNC Symbol;Acc:HGNC:5128]	[more]

BLAST of DthoxE protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mab-5	5.512e-27	66.67	Homeobox protein mab-5 [Source:UniProtKB/Swiss-Pr...	[more]
lin-39	7.082e-26	59.30	Homeobox protein lin-39 [Source:UniProtKB/Swiss-P...	[more]
lin-39	7.082e-26	59.30	Homeobox protein lin-39 [Source:UniProtKB/Swiss-P...	[more]
php-3	8.263e-17	57.81	Posterior Hox gene Paralog [Source:UniProtKB/TrEM...	[more]
php-3	8.263e-17	57.81	Posterior Hox gene Paralog [Source:UniProtKB/TrEM...	[more]

BLAST of DthoxE protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Antp	4.119e-33	78.67	gene:FBgn0260642 transcript:FBtr0081649	[more]
Antp	4.119e-33	78.67	gene:FBgn0260642 transcript:FBtr0081656	[more]
Antp	4.880e-33	78.67	gene:FBgn0260642 transcript:FBtr0081648	[more]
Antp	4.880e-33	78.67	gene:FBgn0260642 transcript:FBtr0081651	[more]
Antp	4.953e-33	77.33	gene:FBgn0260642 transcript:FBtr0081653	[more]

BLAST of DthoxE protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hoxc6a	5.430e-35	65.98	homeobox C6a [Source:NCBI gene;Acc:30346]	[more]
hoxb7a	1.585e-34	73.08	homeobox B7a [Source:NCBI gene;Acc:58044]	[more]
hoxb6a	1.863e-34	75.31	homeobox B6a [Source:NCBI gene;Acc:30341]	[more]
hoxb6b	8.396e-34	75.95	homeobox B6b [Source:NCBI gene;Acc:58053]	[more]
hoxb6b	8.396e-34	75.95	homeobox B6b [Source:NCBI gene;Acc:58053]	[more]

BLAST of DthoxE protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cd276	8.939e-36	80.26	CD276 molecule [Source:Xenbase;Acc:XB-GENE-921537]	[more]
HOXB7	1.950e-35	74.68	homeobox B7 [Source:NCBI gene;Acc:100494663]	[more]
zdhhc15	6.196e-35	68.89	zinc finger DHHC-type containing 15 [Source:Xenbas...	[more]
HOXB6	2.379e-34	75.61	homeobox B6 [Source:NCBI gene;Acc:100124320]	[more]
ppm1j	9.605e-34	68.97	protein phosphatase, Mg2+/Mn2+ dependent 1J [Sourc...	[more]

BLAST of DthoxE protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hoxb7	1.299e-36	73.26	homeobox B7 [Source:MGI Symbol;Acc:MGI:96188]	[more]
Hoxa7	1.614e-36	80.26	homeobox A7 [Source:MGI Symbol;Acc:MGI:96179]	[more]
Hoxb6	5.973e-35	55.12	homeobox B6 [Source:MGI Symbol;Acc:MGI:96187]	[more]
Hoxb6	5.973e-35	55.12	homeobox B6 [Source:MGI Symbol;Acc:MGI:96187]	[more]
Hoxc6	8.976e-34	74.07	homeobox C6 [Source:MGI Symbol;Acc:MGI:96197]	[more]

BLAST of DthoxE protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9TT89\|HXB7_BOVIN	4.626e-37	74.42	Homeobox protein Hox-B7 OS=Bos taurus OX=9913 GN=H...	[more]
sp\|A1YFA5\|HXB7_GORGO	5.771e-37	74.42	Homeobox protein Hox-B7 OS=Gorilla gorilla gorilla...	[more]
sp\|P18864\|HXB7_RAT	2.775e-36	73.26	Homeobox protein Hox-B7 OS=Rattus norvegicus OX=10...	[more]
sp\|P09629\|HXB7_HUMAN	4.589e-36	73.26	Homeobox protein Hox-B7 OS=Homo sapiens OX=9606 GN...	[more]
sp\|P09024\|HXB7_MOUSE	9.089e-36	73.26	Homeobox protein Hox-B7 OS=Mus musculus OX=10090 G...	[more]

BLAST of DthoxE protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
O76939	5.369e-141	81.46	DthoxE protein OS=Girardia tigrina OX=6162 GN=Dtho...	[more]
Q9XY03	9.511e-96	87.04	PLOX6-Dj (Fragment) OS=Dugesia japonica OX=6161 GN...	[more]
Q24681	8.466e-92	83.77	DNA-binding protein (Fragment) OS=Girardia tigrina...	[more]
A0A1S6KMI5	2.975e-66	100.00	Homeobox domain-containing protein OS=Schmidtea me...	[more]
A0A094ZDF2	1.444e-44	85.39	Homeobox protein SMOX-1 (Fragment) OS=Schistosoma ...	[more]

BLAST of DthoxE protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hoxb7a	2.151e-35	66.29	homeobox B7 [Source:NCBI gene;Acc:103045369]	[more]
hoxc6a	1.208e-34	71.76	homeobox C6 [Source:NCBI gene;Acc:103034651]	[more]
hoxb6a	2.866e-34	75.31	homeobox protein Hox-B6a [Source:NCBI gene;Acc:103...	[more]
hoxb6b	8.406e-34	72.84	homeobox protein Hox-B6b [Source:NCBI gene;Acc:103...	[more]
hoxb5b	2.300e-33	69.88	homeobox protein Hox-B5b [Source:NCBI gene;Acc:103...	[more]

BLAST of DthoxE protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hoxb7a	6.208e-32	82.81	homeobox B7a [Source:NCBI gene;Acc:58044]	[more]
hoxd4a	1.695e-31	81.25	homeobox D4a [Source:NCBI gene;Acc:30329]	[more]
ENSPMAT00000005057.1	9.863e-31	64.20	pep scaffold:Pmarinus_7.0:GL483321:9136:13526:-1 g...	[more]
ENSPMAT00000011116.1	2.182e-26	72.41	pep scaffold:Pmarinus_7.0:GL482944:7995:8174:-1 ge...	[more]
ENSPMAT00000011449.1	1.022e-20	70.18	pep scaffold:Pmarinus_7.0:GL493006:3300:3479:1 gen...	[more]

BLAST of DthoxE protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
YOX1	4.265e-6	33.33	Homeobox transcriptional repressor; binds to Mcm1p...	[more]

BLAST of DthoxE protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
ANTHOX1A.NV	1.674e-23	67.16	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42187	1.329e-22	75.86	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
ANTHOX7	2.224e-22	43.94	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
HOX6	1.076e-21	62.32	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45896	8.255e-21	63.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of DthoxE protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HOXA7	6.274e-35	76.32	homeobox A7 [Source:NCBI gene;Acc:110015904]	[more]
hoxc6a	2.199e-34	72.29	homeobox C6 [Source:NCBI gene;Acc:101173938]	[more]
hoxb6b	8.939e-34	71.08	homeobox protein Hox-B6b [Source:NCBI gene;Acc:101...	[more]
ENSORLT00000021320.2	1.403e-33	69.05	homeobox protein Hox-B5a [Source:NCBI gene;Acc:101...	[more]
hoxd4a	1.681e-33	68.54	homeobox D4a [Source:NCBI gene;Acc:30329]	[more]

BLAST of DthoxE protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000079807.1	0.000e+0	100.00	SMESG000079807.1	[more]
SMESG000079807.1	0.000e+0	100.00	SMESG000079807.1	[more]
SMESG000022667.1	1.066e-42	75.82	SMESG000022667.1	[more]
SMESG000044469.1	2.951e-29	63.41	SMESG000044469.1	[more]
SMESG000071019.1	3.277e-29	78.46	SMESG000071019.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30016117 ID=SMED30016117|Name=DthoxE protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1121bp
GTTACATTAAACTCTAAAATCGAATTAATAATAATTTGTCCATTTACATA
TATATGATATGAAACTAATGTATCCAAATTATCATTCCGTTATGCCAGAA
TTTCAATTAAATTGTGAATCAGAAATCTCCTCCAACACAACCATTGGCTA
TGATCATCCAGTTTCCATAACAGAATCTTCATACAATTCAATGAAGAACT
CTTCGAGTTTTACTAGCCCGTCGACGCTGAACAATTCCGGATTAGAATTA
CCTCCGAATTTTTCAATTCCAAGATATTCGGATGAATTCCTATTGACAGG
AAATCAAGACTCATCGAAAAGTTTACCGAATTACTCCCAACAGTCTTGTT
ATTACCTCTATAGGAAACCCTCGAGAACCGAAACTCAAAATCTGAATTTG
CCGTATTCTGGAGCTTGGAAAAATTCCAGCCTATTTTGTCATGGAACGAT
TAACTCAAACTACGAAACGGATTCCAACAATCCTACTAATAATAACAACA
ATAATATTTCTCATATTCGAGCTCTCGGAAACAATGCAATTTGTCAACAT
CTCGGATCGAATCTATTTCATGATCAGCATTTCAAATCCGACATACCTTC
ATTGCACAGTCCTAATAATATCATCAACAACTCTCCCAATCACAATGACA
TGGTTGTTTACCCATGGATGAATCCCAAAATGAATTCAGAATCATCAAGC
GACCACAAACGATCCAGACAAACCTATACACGATATCAAACTCTGGAGCT
GGAAAAAGAATTTCATTTCAATAAATACCTCACTCGACGGAGAAGAATAG
AAATCGCTCACGCATTATCTTTAACGGAAAGGCAAATCAAAATATGGTTT
CAAAACAGGAGAATGAAATGGAAAAAAGACCACAACATCCCGAAACTAAA
CGGCCCAGGAACATTGGAACAATACGAGCAACAATTCGAGAAAGAGCAAC
TGGAGAAACTGGAAGCAAAGACCGATATTGAGGACCATTGCTCCGACACA
GAATCATTGAACACGTAAACCACTTGTATCACCCGGTTCATCAATTTGTA
GAAATTATTTGTACAGCGCTAAAGATGCATGCCAAAGCGTAAAAAAGAAT
TTAAAAAAATAATAATCGAAA

protein sequence of SMED30016117-orf-1

>SMED30016117-orf-1 ID=SMED30016117-orf-1|Name=SMED30016117-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=320bp
MKLMYPNYHSVMPEFQLNCESEISSNTTIGYDHPVSITESSYNSMKNSSS
FTSPSTLNNSGLELPPNFSIPRYSDEFLLTGNQDSSKSLPNYSQQSCYYL
YRKPSRTETQNLNLPYSGAWKNSSLFCHGTINSNYETDSNNPTNNNNNNI
SHIRALGNNAICQHLGSNLFHDQHFKSDIPSLHSPNNIINNSPNHNDMVV
YPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIA
HALSLTERQIKIWFQNRRMKWKKDHNIPKLNGPGTLEQYEQQFEKEQLEK
LEAKTDIEDHCSDTESLNT*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000103	central nervous system
PLANA:0002089	reproductive organ
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR017995	Homeobox_antennapedia
IPR020479	Homeobox_metazoa
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0003700	transcription factor activity, sequence-specific DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 286..306
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 195..276 e-value: 9.5E-33 score: 114.0
None	No IPR available	PANTHER	PTHR45659:SF4	HOMEOTIC PROTEIN ULTRABITHORAX	coord: 58..306
None	No IPR available	PANTHER	PTHR45659	FAMILY NOT NAMED	coord: 58..306
IPR017995	Homeobox protein, antennapedia type	PRINTS	PR00025	ANTENNAPEDIA	coord: 199..206 score: 46.61 coord: 217..232 score: 66.96
IPR020479	Homeobox domain, metazoa	PRINTS	PR00024	HOMEOBOX	coord: 253..263 score: 66.0 coord: 238..249 score: 51.06 coord: 263..272 score: 83.3
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 216..278 e-value: 1.2E-26 score: 104.5
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 217..273 e-value: 2.7E-21 score: 75.1
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 214..274 score: 21.54
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 217..275 e-value: 1.09097E-24 score: 92.6916
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 249..272
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 194..273