Epidermal growth factor-8
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppSub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30016070 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of Epidermal growth factor-8 vs. TrEMBL
Match: A0A161HX36 (Epidermal growth factor-8 OS=Schmidtea mediterranea OX=79327 GN=egf-8 PE=2 SV=1) HSP 1 Score: 112.464 bits (280), Expect = 4.958e-40 Identity = 55/133 (41.35%), Postives = 82/133 (61.65%), Query Frame = 2 Query: 329 LKKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKCNQLL-------TTKKPTFSTSQQ 706 + ISI V++DD DS DHIAKF+ F ++ G++ +K++ V P + +V LQAS+S KC+ YYG C++ +++ C CINGKC +N +K FFC C W G+ CN+ + +TK PT TSQ+ Sbjct: 103 INSISISVRVDDVDSGGISDHIAKFRTSFNIETPGLIDRKTMSVEPANVKVSLQASVSVKCALNYYGNKCEERSDKFICNSSCINGKCNFNYQKDTFFCQCYNGWDGINCNKSIFINNLSSSTKLPTKHTSQR 235 HSP 2 Score: 83.9593 bits (206), Expect = 4.958e-40 Identity = 34/79 (43.04%), Postives = 53/79 (67.09%), Query Frame = 3 Query: 78 VIIRQNDGNIFLNVRLFNYKNPSDVRYDGRNCEKFYWAGDYCDPVFRICISAKQKCDLLNKKTNVFNNMKEIFTVFTES 314 ++I L V ++NY+N D+++D + CE F+WA D+CDP+F ICI+ K CD+ TNVF+N K+I+ VFT++ Sbjct: 18 ILISPITTKAILKVYIYNYQNHEDMKHDEKKCETFHWANDHCDPIFEICITEKSLCDVFKTTTNVFDNSKKIYNVFTQT 96
BLAST of Epidermal growth factor-8 vs. TrEMBL
Match: A0A419QGW3 (EGF-like domain-containing protein OS=Clonorchis sinensis OX=79923 GN=CSKR_5660s PE=4 SV=1) HSP 1 Score: 40.817 bits (94), Expect = 9.432e-6 Identity = 25/84 (29.76%), Postives = 42/84 (50.00%), Query Frame = 3 Query: 75 MVIIRQNDGNIFLNVRLFNYKNPSDVRYDGRNCEKFYWAGDYCDPVFRICI----SAKQKCDLLNKKTNVFNNMKEIFTVFTES 314 +++ + + N+ L VR + KN D R R CE + GD CDP+F++ + S ++ LL ++ F N K + V S Sbjct: 9 LLLSARAEVNLLLTVRNYENKNNLDSRL--RKCEALSFLGDNCDPIFQLTVHVTNSRNERHLLLRREAGPFTNKKVLKEVLQTS 90 HSP 2 Score: 40.0466 bits (92), Expect = 9.432e-6 Identity = 31/120 (25.83%), Postives = 47/120 (39.17%), Query Frame = 2 Query: 338 ISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCD-------------KDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKC 658 I I + I D D+ D IA+F+ I L G L + S V+++ + +C+ YYG C+ C K CI G C+ + C+C W+G C Sbjct: 100 IEIALDIYDNDA-DEDQLIARFRRIIPLLKTGQLDLQM------GSDVKVKVLLKVECATNYYGERCEIYCQPSPQLWTCNSLTGARMCNKPCIQGSCVLT--NTSAVCVCAPGWSGEFC 210
BLAST of Epidermal growth factor-8 vs. Planmine SMEST
Match: SMESG000077699.1 (SMESG000077699.1) HSP 1 Score: 1182.55 bits (3058), Expect = 0.000e+0 Identity = 643/643 (100.00%), Postives = 643/643 (100.00%), Query Frame = 2 Query: 332 KKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKCNQLLTTKKPTFSTSQQTKDLRLNISKIKFLNFKKDLVKTTDXXXXXXXXXXXXXXXXXXXFTTPSKQIHNSTKFYKKINTKHISNFSTNISSLKPISTPININVFNQKTKTQKLDYATSSSATISTKPLSSKFTSAMESLFNFKLYKENYAKKFDKNLIFRKESVSPEIYRVNSFTKPSTSVNPNLSSSKIHQNLKSTQLLSSNFVISSTENSLNKHKVKTITFNKQGFAFNDIDEKYTSSISKKANSVTFNIKHFSKFSTHIPYVNKFNFNTSDKHXXXXXXXXXXXXXXFAFKKNQMSNKYKLFTTSSQPSVLTKGNDVHKKTAIQLISYKFNLSAFTSKIINQNSITKINKIYLETSNKSVNLTESNFNNASFTYLRMSVLKLLNQTFHNKYLIAICGAFWFCXXXXXXXXXXRKKQRINKFDTNKFIYRHQKAPTTNYHEPDLESEEVNIIQTTNPSIPFKSKILTQKPATEINNKNNDDSNEYETILRNLNNPNTESYVRLTYFSKTSEKPEKNENFRPTNNTKDFSNC 2260 KKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKCNQLLTTKKPTFSTSQQTKDLRLNISKIKFLNFKKDLVKTTDISISKKSSKSSKPFKIIYIFTTPSKQIHNSTKFYKKINTKHISNFSTNISSLKPISTPININVFNQKTKTQKLDYATSSSATISTKPLSSKFTSAMESLFNFKLYKENYAKKFDKNLIFRKESVSPEIYRVNSFTKPSTSVNPNLSSSKIHQNLKSTQLLSSNFVISSTENSLNKHKVKTITFNKQGFAFNDIDEKYTSSISKKANSVTFNIKHFSKFSTHIPYVNKFNFNTSDKHILSSKSSLKVSTTIFAFKKNQMSNKYKLFTTSSQPSVLTKGNDVHKKTAIQLISYKFNLSAFTSKIINQNSITKINKIYLETSNKSVNLTESNFNNASFTYLRMSVLKLLNQTFHNKYLIAICGAFWFCLIIMLIIIVIRKKQRINKFDTNKFIYRHQKAPTTNYHEPDLESEEVNIIQTTNPSIPFKSKILTQKPATEINNKNNDDSNEYETILRNLNNPNTESYVRLTYFSKTSEKPEKNENFRPTNNTKDFSNC Sbjct: 19 KKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKCNQLLTTKKPTFSTSQQTKDLRLNISKIKFLNFKKDLVKTTDISISKKSSKSSKPFKIIYIFTTPSKQIHNSTKFYKKINTKHISNFSTNISSLKPISTPININVFNQKTKTQKLDYATSSSATISTKPLSSKFTSAMESLFNFKLYKENYAKKFDKNLIFRKESVSPEIYRVNSFTKPSTSVNPNLSSSKIHQNLKSTQLLSSNFVISSTENSLNKHKVKTITFNKQGFAFNDIDEKYTSSISKKANSVTFNIKHFSKFSTHIPYVNKFNFNTSDKHILSSKSSLKVSTTIFAFKKNQMSNKYKLFTTSSQPSVLTKGNDVHKKTAIQLISYKFNLSAFTSKIINQNSITKINKIYLETSNKSVNLTESNFNNASFTYLRMSVLKLLNQTFHNKYLIAICGAFWFCLIIMLIIIVIRKKQRINKFDTNKFIYRHQKAPTTNYHEPDLESEEVNIIQTTNPSIPFKSKILTQKPATEINNKNNDDSNEYETILRNLNNPNTESYVRLTYFSKTSEKPEKNENFRPTNNTKDFSNC 661
BLAST of Epidermal growth factor-8 vs. Planmine SMEST
Match: SMESG000077699.1 (SMESG000077699.1) HSP 1 Score: 583.563 bits (1503), Expect = 0.000e+0 Identity = 312/314 (99.36%), Postives = 314/314 (100.00%), Query Frame = 2 Query: 332 KKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKCNQLLTTKKPTFSTSQQTKDLRLNISKIKFLNFKKDLVKTTDXXXXXXXXXXXXXXXXXXXFTTPSKQIHNSTKFYKKINTKHISNFSTNISSLKPISTPININVFNQKTKTQKLDYATSSSATISTKPLSSKFTSAMESLFNFKLYKENYAKKFDKNLIFRKESVSPEIYRVNSFTKPSTSVNPNLSSSKIHQNLKSTQLLSSNF 1273 KKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKCNQLLTTKKPTFSTSQQTKDLRLNISKIKFLNFKKDLVKTTDISISKKSSKSSKPFKIIYIFTTPSKQIHNSTKFYKKINTKHISNFSTNISSLKPISTPININVFNQKTKTQKLDYATSSSATISTKPLSSKFTSAMESLFNFKLYKENYAKKFDKNLIFRKESVSPEIYRVNSFTKPSTSVNPNLSSSKIHQNLKSTQLLS++F Sbjct: 19 KKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKCNQLLTTKKPTFSTSQQTKDLRLNISKIKFLNFKKDLVKTTDISISKKSSKSSKPFKIIYIFTTPSKQIHNSTKFYKKINTKHISNFSTNISSLKPISTPININVFNQKTKTQKLDYATSSSATISTKPLSSKFTSAMESLFNFKLYKENYAKKFDKNLIFRKESVSPEIYRVNSFTKPSTSVNPNLSSSKIHQNLKSTQLLSTSF 332 HSP 2 Score: 312.383 bits (799), Expect = 1.212e-97 Identity = 164/178 (92.13%), Postives = 167/178 (93.82%), Query Frame = 2 Query: 1727 LETSNKSVNLTESNFNNASFTYLRMSVLKLLNQTFHNKYLIAICGAFWFCXXXXXXXXXXRKKQRINKFDTNKFIYRHQKAPTTNYHEPDLESEEVNIIQTTNPSIPFKSKILTQKPATEINNKNNDDSNEYETILRNLNNPNTESYVRLTYFSKTSEKPEKNENFRPTNNTKDFSNC 2260 L +S NL + + SFTYLRMSVLKLLNQTFHNKYLIAICGAFWFCLIIMLIIIVIRKKQRINKFDTNKFIYRHQKAPTTNYHEPDLESEEVNIIQTTNPSIPFKSKILTQKPATEINNKNNDDSNEYETILRNLNNPNTESYVRLTYFSKTSEKPEKNENFRPTNNTKDFSNC Sbjct: 313 LSSSKIHQNLKSTQLLSTSFTYLRMSVLKLLNQTFHNKYLIAICGAFWFCLIIMLIIIVIRKKQRINKFDTNKFIYRHQKAPTTNYHEPDLESEEVNIIQTTNPSIPFKSKILTQKPATEINNKNNDDSNEYETILRNLNNPNTESYVRLTYFSKTSEKPEKNENFRPTNNTKDFSNC 490
BLAST of Epidermal growth factor-8 vs. Planmine SMEST
Match: SMESG000077702.1 (SMESG000077702.1) HSP 1 Score: 113.235 bits (282), Expect = 2.822e-43 Identity = 55/133 (41.35%), Postives = 82/133 (61.65%), Query Frame = 2 Query: 329 LKKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKCNQLL-------TTKKPTFSTSQQ 706 + ISI V++DD DS DHIAKF+ F ++ G++ +K++ V P + +V LQAS+S KC+ YYG C++ +++ C CINGKC +N +K FFC C W G+ CN+ + +TK PT TSQ+ Sbjct: 103 INSISISVRVDDVDSGGISDHIAKFRTSFNIETPGLIDRKTMSVEPANVKVSLQASVSVKCALNYYGNKCEERSDKFTCNSSCINGKCNFNYQKDTFFCQCYNGWDGINCNKSIFINNLSSSTKLPTKHTSQR 235 HSP 2 Score: 82.8037 bits (203), Expect = 2.822e-43 Identity = 34/79 (43.04%), Postives = 52/79 (65.82%), Query Frame = 3 Query: 78 VIIRQNDGNIFLNVRLFNYKNPSDVRYDGRNCEKFYWAGDYCDPVFRICISAKQKCDLLNKKTNVFNNMKEIFTVFTES 314 ++I L V ++NY+N D+++D CE F+WA D+CDP+F ICI+ K CD+ TNVF+N K+I+ VFT++ Sbjct: 18 ILISPITTKAILKVYIYNYQNHEDMKHDKNKCETFHWANDHCDPIFEICITEKSLCDVFKTTTNVFDNSKKIYNVFTQT 96
BLAST of Epidermal growth factor-8 vs. Planmine SMEST
Match: SMESG000077702.1 (SMESG000077702.1) HSP 1 Score: 113.235 bits (282), Expect = 3.248e-43 Identity = 55/133 (41.35%), Postives = 82/133 (61.65%), Query Frame = 2 Query: 329 LKKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKCNQLL-------TTKKPTFSTSQQ 706 + ISI V++DD DS DHIAKF+ F ++ G++ +K++ V P + +V LQAS+S KC+ YYG C++ +++ C CINGKC +N +K FFC C W G+ CN+ + +TK PT TSQ+ Sbjct: 101 INSISISVRVDDVDSGGISDHIAKFRTSFNIETPGLIDRKTMSVEPANVKVSLQASVSVKCALNYYGNKCEERSDKFTCNSSCINGKCNFNYQKDTFFCQCYNGWDGINCNKSIFINNLSSSTKLPTKHTSQR 233 HSP 2 Score: 82.8037 bits (203), Expect = 3.248e-43 Identity = 34/79 (43.04%), Postives = 52/79 (65.82%), Query Frame = 3 Query: 78 VIIRQNDGNIFLNVRLFNYKNPSDVRYDGRNCEKFYWAGDYCDPVFRICISAKQKCDLLNKKTNVFNNMKEIFTVFTES 314 ++I L V ++NY+N D+++D CE F+WA D+CDP+F ICI+ K CD+ TNVF+N K+I+ VFT++ Sbjct: 16 ILISPITTKAILKVYIYNYQNHEDMKHDKNKCETFHWANDHCDPIFEICITEKSLCDVFKTTTNVFDNSKKIYNVFTQT 94
BLAST of Epidermal growth factor-8 vs. Planmine SMEST
Match: SMESG000077703.1 (SMESG000077703.1) HSP 1 Score: 85.5001 bits (210), Expect = 1.507e-32 Identity = 37/88 (42.05%), Postives = 59/88 (67.05%), Query Frame = 3 Query: 63 FVYLMVII-RQNDGNIFLNVRLFNYKNPSDVRYDGRNCEKFYWAGDYCDPVFRICISAKQKCDLLNKKTNVFNNMKEIFTVFTESIPL 323 F+Y+++ I Q L + + NYKN +++++DG CE F WA D CDP+F+IC++AK CD+LNKK + + N K ++TV ++ I L Sbjct: 12 FLYILLQINHQTKAKAVLTIHILNYKNYANLKHDGNKCETFDWANDNCDPMFQICVTAKNPCDILNKKIDHWPNAKTLYTVLSQKIEL 99 HSP 2 Score: 74.7146 bits (182), Expect = 1.507e-32 Identity = 36/109 (33.03%), Postives = 59/109 (54.13%), Query Frame = 2 Query: 332 KKISIEVKIDDEDSYDNIDHIAKFQGIFYLQAVGILSQKSLMVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNERKKAFFCLCDKTWTGLKC 658 +K+S+ V++DD D +D DHIA F F ++ + + ++ + + P + + LQ S+ KC+ YYG C+K + C + CI+GKC +N K C C W C Sbjct: 104 RKLSVIVQVDDHDRFDAPDHIAIFTTSFQIKDLNVFYKQKMQIKPKNLDISLQTSVMIKCADSYYGNNCEKKRTQ--CKQSCIHGKCSFNIEKNQETCECFSGWDLPNC 210 The following BLAST results are available for this feature:
BLAST of Epidermal growth factor-8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Epidermal growth factor-8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Epidermal growth factor-8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 2
BLAST of Epidermal growth factor-8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Epidermal growth factor-8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30016070 ID=SMED30016070|Name=Epidermal growth factor-8|organism=Schmidtea mediterranea sexual|type=transcript|length=2339bpback to top protein sequence of SMED30016070-orf-1 >SMED30016070-orf-1 ID=SMED30016070-orf-1|Name=SMED30016070-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=603bp MVNPPSSRVRLQASISTKCSPGYYGALCDKDYNEYKCIKDCINGKCLWNEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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