VPS37C subunit of ESCRT-I

Overview


Name	VPS37C subunit of ESCRT-I
Smed ID	SMED30016048
Length (bp)	914

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of VPS37C subunit of ESCRT-I (SMED30016048) t-SNE clustered cells

Violin plots show distribution of expression levels for VPS37C subunit of ESCRT-I (SMED30016048) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of VPS37C subunit of ESCRT-I (SMED30016048) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for VPS37C subunit of ESCRT-I (SMED30016048) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30016048

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
gut	SMED30016048	h1SMcG0009317	Contig5669	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30016048	h1SMcG0009317	Contig5669	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30016048	h1SMcG0009317	Contig5669	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30016048	h1SMcG0009317	Contig5669	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30016048	h1SMcG0021644	Contig5669	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30016048	h1SMcG0021644	Contig5669	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30016048	h1SMcG0021644	Contig5669	newmark_ests	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30016048	h1SMcG0021644	Contig5669	uc_Smed_v2	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30016048	h1SMcG0021644	Contig2668	GPL15192	PMID:23079596 Forsthoefel et al., 2012

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Human
Match: VPS37C (VPS37C subunit of ESCRT-I [Source:HGNC Symbol;Acc:HGNC:26097])

HSP 1 Score: 73.9442 bits (180), Expect = 2.460e-14
Identity = 43/128 (33.59%), Postives = 73/128 (57.03%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL + Y  LRK+ +  ++ ++KLE +     P  ++ LL + GM + EE+SE  AE F+     +E F+ENF   R L H RR++V++LQ+
Sbjct:   29 SPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGM-KIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQE 155

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Human
Match: VPS37C (VPS37C subunit of ESCRT-I [Source:HGNC Symbol;Acc:HGNC:26097])

HSP 1 Score: 66.6254 bits (161), Expect = 6.458e-13
Identity = 38/120 (31.67%), Postives = 63/120 (52.50%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRI 609
            S ++  +Q  +E  L  N  +A +N E++  L   + NL + Y  LRK+ +  ++ ++KLE +     P  ++ LL     + EE+SE  AE F+     +E F+ENF   R L H RR+
Sbjct:   29 SPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRV 148

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Human
Match: VPS37B (VPS37B subunit of ESCRT-I [Source:HGNC Symbol;Acc:HGNC:25754])

HSP 1 Score: 60.4622 bits (145), Expect = 2.009e-10
Identity = 40/127 (31.50%), Postives = 67/127 (52.76%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S Q  ++Q +KE  L  N  +A  N  Y+P L   K  L  +Y  L+ + +  +  ++KL+      S   ++ LL A  A+ EE +E  AE F+     ++ FI+ +  KR L H RR+K+++LQ+
Sbjct:   33 SCQTQNVQLNKEMTLASNRSLAEGNLLYQPQLDTLKARLTQKYQELQVLFEAYQIKKTKLDRQSSSASLETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQE 159

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Human
Match: VPS37B (VPS37B subunit of ESCRT-I [Source:HGNC Symbol;Acc:HGNC:25754])

HSP 1 Score: 58.151 bits (139), Expect = 3.958e-9
Identity = 38/121 (31.40%), Postives = 64/121 (52.89%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            +Q +KE  L  N  +A  N  Y+P L   K  L  +Y  L+ + +  +  ++KL+      S   ++ LL A  A+ EE +E  AE F+     ++ FI+ +  KR L H RR+K+++LQ+
Sbjct:   41 VQLNKEMTLASNRSLAEGNLLYQPQLDTLKARLTQKYQELQVLFEAYQIKKTKLDRQSSSASLETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQE 161

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Human
Match: VPS37B (VPS37B subunit of ESCRT-I [Source:HGNC Symbol;Acc:HGNC:25754])

HSP 1 Score: 57.7658 bits (138), Expect = 4.172e-9
Identity = 38/121 (31.40%), Postives = 64/121 (52.89%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            +Q +KE  L  N  +A  N  Y+P L   K  L  +Y  L+ + +  +  ++KL+      S   ++ LL A  A+ EE +E  AE F+     ++ FI+ +  KR L H RR+K+++LQ+
Sbjct:   39 VQLNKEMTLASNRSLAEGNLLYQPQLDTLKARLTQKYQELQVLFEAYQIKKTKLDRQSSSASLETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQE 159

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Celegans
Match: vps-37 (Related to yeast Vacuolar Protein Sorting factor [Source:UniProtKB/TrEMBL;Acc:O44158])

HSP 1 Score: 52.7582 bits (125), Expect = 6.441e-8
Identity = 34/123 (27.64%), Postives = 61/123 (49.59%), Query Frame = 1

Query:  256 QIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQL 624
            Q+ SM   KE  L  N  +A  N   +P +   K   ++ YD ++K+Q     L+S+L+S     S +   +L+     E+++ +E     F      +E F++ F +K+ + H R+IK D+L
Sbjct:   49 QVRSMPTDKESALAANKSLAEWNLAQKPRIDAAKTQTVDLYDQVKKLQGEVAVLKSQLDSVSSSKSLDTTSSLMQVAAQEADDDAEALFTQFENGEISVEIFLKQFKDKKTIAHLRKIKSDRL 171

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Fly
Match: Vps37B (gene:FBgn0037299 transcript:FBtr0078777)

HSP 1 Score: 47.7506 bits (112), Expect = 3.152e-6
Identity = 34/131 (25.95%), Postives = 61/131 (46.56%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSP----------NNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            ++  K  +  DN   A +N E EP + + +  L           +++ED R++  S ++K S              + LL    +ESEEQ+E+  + F      +E F++ FL  R   H RR+K +++Q+
Sbjct:   42 LRTQKTSVFEDNRSRAERNIEREPQIIELRGQLA----------ELSEDGRTRCSSVQEKLSQLKEKSGGVGLETALALLQTAASESEEQTEEMVKKFNDSDIGVEDFLDAFLPIRRTMHLRRLKAEKMQE 162

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Fly
Match: Vps37B (gene:FBgn0037299 transcript:FBtr0305001)

HSP 1 Score: 47.7506 bits (112), Expect = 3.152e-6
Identity = 34/131 (25.95%), Postives = 61/131 (46.56%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSP----------NNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            ++  K  +  DN   A +N E EP + + +  L           +++ED R++  S ++K S              + LL    +ESEEQ+E+  + F      +E F++ FL  R   H RR+K +++Q+
Sbjct:   42 LRTQKTSVFEDNRSRAERNIEREPQIIELRGQLA----------ELSEDGRTRCSSVQEKLSQLKEKSGGVGLETALALLQTAASESEEQTEEMVKKFNDSDIGVEDFLDAFLPIRRTMHLRRLKAEKMQE 162

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Fly
Match: Vps37B (gene:FBgn0037299 transcript:FBtr0305002)

HSP 1 Score: 47.7506 bits (112), Expect = 3.152e-6
Identity = 34/131 (25.95%), Postives = 61/131 (46.56%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSP----------NNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            ++  K  +  DN   A +N E EP + + +  L           +++ED R++  S ++K S              + LL    +ESEEQ+E+  + F      +E F++ FL  R   H RR+K +++Q+
Sbjct:   42 LRTQKTSVFEDNRSRAERNIEREPQIIELRGQLA----------ELSEDGRTRCSSVQEKLSQLKEKSGGVGLETALALLQTAASESEEQTEEMVKKFNDSDIGVEDFLDAFLPIRRTMHLRRLKAEKMQE 162

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Zebrafish
Match: si:ch211-284f22.3 (si:ch211-284f22.3 [Source:ZFIN;Acc:ZDB-GENE-060526-166])

HSP 1 Score: 64.3142 bits (155), Expect = 2.323e-11
Identity = 38/130 (29.23%), Postives = 68/130 (52.31%), Query Frame = 1

Query:  241 INTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            +  S +   +Q  ++ LL+ N  +A  +    P L++ K  L  +Y+ L  +     + +S+LE++ +K SP     LL   +  +EEQSE+  E FM     +E+F++ F   R  YH RR + ++LQ+
Sbjct:   51 VRLSEKFQELQMDRDTLLVTNRSLAEDSLTRRPHLQNGKLQLAAKYEELATLSTACREKQSRLEAFTEKHSPQTAHNLLQEEVTRAEEQSEELLERFMEGHVPLEEFLDCFQSHRKTYHIRRAQAEKLQE 180

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Zebrafish
Match: vps37c (VPS37C subunit of ESCRT-I [Source:ZFIN;Acc:ZDB-GENE-061110-126])

HSP 1 Score: 59.6918 bits (143), Expect = 8.016e-10
Identity = 35/127 (27.56%), Postives = 71/127 (55.91%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S +I ++Q  +E  L  N  +A +N + +P + + +  L+ +Y  L  +++  +      +S   + SP  +++ L A  A +E +SE  A+ F+  S  ++ F+E FL  R+L H RR+++++LQ+
Sbjct:   29 SDEIQNIQLEREMALAANRSLAEQNLDMKPRIENDRARLVEKYTELEAVREKYKQHCVLRDSIMGQVSPEGLLSRLQAEGASTEAESEALADEFLEGSISLDSFLERFLSLRSLAHTRRVRIEKLQE 155

[Close]

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S +I ++Q  +E  L  N  +A +N + +P + + +  L+ +Y  L  +++  +      +S   + SP  +++ L A  A +E +SE  A+ F+  S  ++ F+E FL  R+L H RR+++++LQ+
Sbjct:   29 SDEIQNIQLEREMALAANRSLAEQNLDMKPRIENDRARLVEKYTELEAVREKYKQHCVLRDSIMGQVSPEGLLSRLQAEGASTEAESEALADEFLEGSISLDSFLERFLSLRSLAHTRRVRIEKLQE 155

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Zebrafish
Match: vps37b (VPS37B subunit of ESCRT-I [Source:ZFIN;Acc:ZDB-GENE-060526-254])

HSP 1 Score: 58.9214 bits (141), Expect = 1.197e-9
Identity = 38/130 (29.23%), Postives = 73/130 (56.15%), Query Frame = 1

Query:  241 INTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            I+ S +I  +Q++KE  L +N  +A +N   +P L   K  L   Y  L+++ +  +  +S L+        + ++ LL A  A+ EE++E  A+ F+  +  ++ FI+++  KR L H RR+K+++LQ+
Sbjct:   30 IDESEEIKGLQQNKETTLANNRFLAEQNLLLQPKLDHQKNELTRRYRGLQELYEAYQLRKSTLDDRLGNTPLDTLLALLQAEGAKIEEETENLADAFLDGAAPLDTFIDDYQSKRKLAHLRRVKIEKLQE 159

[Close]

Query:  241 INTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            I+ S +I  +Q++KE  L +N  +A +N   +P L   K  L   Y  L+++ +  +  +S L+        + ++ LL A  A+ EE++E  A+ F+  +  ++ FI+++  KR L H RR+K+++LQ+
Sbjct:   30 IDESEEIKGLQQNKETTLANNRFLAEQNLLLQPKLDHQKNELTRRYRGLQELYEAYQLRKSTLDDRLGNTPLDTLLALLQAEGAKIEEETENLADAFLDGAAPLDTFIDDYQSKRKLAHLRRVKIEKLQE 159

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Xenopus
Match: vps37b (VPS37B, ESCRT-I subunit [Source:NCBI gene;Acc:394642])

HSP 1 Score: 59.3066 bits (142), Expect = 1.515e-9
Identity = 37/121 (30.58%), Postives = 65/121 (53.72%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            +Q  KE  L  N  +A  N   +P L   K  L  +Y  L+ + + ++  ++KL+      S   ++ LL A  A+ EE++E  AENF+     ++ F + ++ KR L H RR+K+++LQ+
Sbjct:   39 VQLSKEMTLAGNRSLAEGNLLLQPDLETLKATLTQKYQELQSLIESHQLKKTKLDKQSVNSSLETLLALLQAEGAKIEEETENMAENFLDGGIQLDNFTDEYMNKRKLAHLRRVKIEKLQE 159

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Xenopus
Match: vps37a (vacuolar protein sorting 37 homolog A [Source:NCBI gene;Acc:548736])

HSP 1 Score: 53.5286 bits (127), Expect = 1.657e-7
Identity = 33/116 (28.45%), Postives = 66/116 (56.90%), Query Frame = 1

Query:  280 KEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQ 627
            KE+L+ +  ++A +N + EP L   +Q ++++Y+ L +++   E    +     +  S + +   L     E+EE+S+K A+ F+    +I++F+ NF++KR   H RR K ++LQ
Sbjct:  253 KEELVRNIEEMAKRNLQMEPVLEVKRQAILDKYEQLMQLKLSFEKKLQRQHELSESCSLSALQARLKVAAHEAEEESDKIADEFLEGKIEIDEFLVNFMDKRTCCHSRRAKEEKLQ 368

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Xenopus
Match: vps37a (vacuolar protein sorting 37 homolog A [Source:NCBI gene;Acc:548736])

HSP 1 Score: 53.1434 bits (126), Expect = 2.012e-7
Identity = 33/116 (28.45%), Postives = 66/116 (56.90%), Query Frame = 1

Query:  280 KEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQ 627
            KE+L+ +  ++A +N + EP L   +Q ++++Y+ L +++   E    +     +  S + +   L     E+EE+S+K A+ F+    +I++F+ NF++KR   H RR K ++LQ
Sbjct:  255 KEELVRNIEEMAKRNLQMEPVLEVKRQAILDKYEQLMQLKLSFEKKLQRQHELSESCSLSALQARLKVAAHEAEEESDKIADEFLEGKIEIDEFLVNFMDKRTCCHSRRAKEEKLQ 370

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Mouse
Match: Vps37c (vacuolar protein sorting 37C [Source:MGI Symbol;Acc:MGI:2147661])

HSP 1 Score: 75.485 bits (184), Expect = 5.410e-15
Identity = 43/128 (33.59%), Postives = 74/128 (57.81%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL ++Y  LRK+ +  ++ ++KLE +     P  ++ LL + GM + EE+SE  AE F+     +E F+E+F   R L H RR++V++LQD
Sbjct:   29 SPEVQDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGM-KIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQD 155

[Close]

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL ++Y  LRK+ +  ++ ++KLE +     P  ++ LL + GM + EE+SE  AE F+     +E F+E+F   R L H RR++V++LQD
Sbjct:   29 SPEVQDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGM-KIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQD 155

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Mouse
Match: Vps37b (vacuolar protein sorting 37B [Source:MGI Symbol;Acc:MGI:1916724])

HSP 1 Score: 57.3806 bits (137), Expect = 4.324e-9
Identity = 39/122 (31.97%), Postives = 66/122 (54.10%), Query Frame = 1

Query:  265 SMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            ++Q +KE  L  N  +A  N  Y+P L   K  L  +Y  L+ + +  +  ++KL+   +  S   ++ LL A  A+ EE +E  AE F+     ++ FI+ +  KR L H RR+KV++LQ+
Sbjct:   40 TVQLNKEMTLASNRSLAEGNLLYQPQLDAQKARLTQKYQELQVLFEAYQIKKTKLDKQSNNASLETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKVEKLQE 161

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. UniProt/SwissProt
Match: sp|Q8R105|VP37C_MOUSE (Vacuolar protein sorting-associated protein 37C OS=Mus musculus OX=10090 GN=Vps37c PE=1 SV=1)

HSP 1 Score: 75.485 bits (184), Expect = 3.784e-14
Identity = 43/128 (33.59%), Postives = 74/128 (57.81%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL ++Y  LRK+ +  ++ ++KLE +     P  ++ LL + GM + EE+SE  AE F+     +E F+E+F   R L H RR++V++LQD
Sbjct:   29 SPEVQDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGM-KIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQD 155

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. UniProt/SwissProt
Match: sp|A5D8V6|VP37C_HUMAN (Vacuolar protein sorting-associated protein 37C OS=Homo sapiens OX=9606 GN=VPS37C PE=1 SV=2)

HSP 1 Score: 73.9442 bits (180), Expect = 1.181e-13
Identity = 43/128 (33.59%), Postives = 73/128 (57.03%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL + Y  LRK+ +  ++ ++KLE +     P  ++ LL + GM + EE+SE  AE F+     +E F+ENF   R L H RR++V++LQ+
Sbjct:   29 SPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGM-KIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQE 155

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. UniProt/SwissProt
Match: sp|Q5R9T2|VP37C_PONAB (Vacuolar protein sorting-associated protein 37C OS=Pongo abelii OX=9601 GN=VPS37C PE=2 SV=1)

HSP 1 Score: 72.0182 bits (175), Expect = 6.283e-13
Identity = 42/128 (32.81%), Postives = 73/128 (57.03%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL ++Y  LRK+ +  ++ ++KLE +     P  ++ LL + GM + E +SE  AE F+     +E F+ENF   R L H RR++V++LQ+
Sbjct:   29 SPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGM-KIEGESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQE 155

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. UniProt/SwissProt
Match: sp|Q9H9H4|VP37B_HUMAN (Vacuolar protein sorting-associated protein 37B OS=Homo sapiens OX=9606 GN=VPS37B PE=1 SV=1)

HSP 1 Score: 58.151 bits (139), Expect = 1.901e-8
Identity = 38/121 (31.40%), Postives = 64/121 (52.89%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            +Q +KE  L  N  +A  N  Y+P L   K  L  +Y  L+ + +  +  ++KL+      S   ++ LL A  A+ EE +E  AE F+     ++ FI+ +  KR L H RR+K+++LQ+
Sbjct:   41 VQLNKEMTLASNRSLAEGNLLYQPQLDTLKARLTQKYQELQVLFEAYQIKKTKLDRQSSSASLETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQE 161

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. UniProt/SwissProt
Match: sp|Q8R0J7|VP37B_MOUSE (Vacuolar protein sorting-associated protein 37B OS=Mus musculus OX=10090 GN=Vps37b PE=1 SV=1)

HSP 1 Score: 57.3806 bits (137), Expect = 3.025e-8
Identity = 39/122 (31.97%), Postives = 66/122 (54.10%), Query Frame = 1

Query:  265 SMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            ++Q +KE  L  N  +A  N  Y+P L   K  L  +Y  L+ + +  +  ++KL+   +  S   ++ LL A  A+ EE +E  AE F+     ++ FI+ +  KR L H RR+KV++LQ+
Sbjct:   40 TVQLNKEMTLASNRSLAEGNLLYQPQLDAQKARLTQKYQELQVLFEAYQIKKTKLDKQSNNASLETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKVEKLQE 161

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. TrEMBL
Match: G1SMB5 (VPS37C subunit of ESCRT-I OS=Oryctolagus cuniculus OX=9986 GN=VPS37C PE=4 SV=2)

HSP 1 Score: 78.9518 bits (193), Expect = 9.346e-13
Identity = 44/128 (34.38%), Postives = 75/128 (58.59%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL ++Y  LRK+ +  ++ ++KLE++     P  ++ LL + GM + EE+SE  AE F+     +E F+ENF   R L H RR++V++LQD
Sbjct:   43 SPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLETFASALQPGALLDLLQIEGM-KIEEESEAMAEKFLEGEVPLETFLENFSSMRTLSHLRRVRVEKLQD 169

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. TrEMBL
Match: A0A5F9D843 (VPS37C subunit of ESCRT-I OS=Oryctolagus cuniculus OX=9986 GN=VPS37C PE=4 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 1.063e-12
Identity = 44/128 (34.38%), Postives = 75/128 (58.59%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL ++Y  LRK+ +  ++ ++KLE++     P  ++ LL + GM + EE+SE  AE F+     +E F+ENF   R L H RR++V++LQD
Sbjct:   29 SPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLETFASALQPGALLDLLQIEGM-KIEEESEAMAEKFLEGEVPLETFLENFSSMRTLSHLRRVRVEKLQD 155

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. TrEMBL
Match: A0A5F9DK27 (VPS37C subunit of ESCRT-I OS=Oryctolagus cuniculus OX=9986 GN=VPS37C PE=4 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 1.130e-12
Identity = 44/128 (34.38%), Postives = 75/128 (58.59%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL ++Y  LRK+ +  ++ ++KLE++     P  ++ LL + GM + EE+SE  AE F+     +E F+ENF   R L H RR++V++LQD
Sbjct:   60 SPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLETFASALQPGALLDLLQIEGM-KIEEESEAMAEKFLEGEVPLETFLENFSSMRTLSHLRRVRVEKLQD 186

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. TrEMBL
Match: I3M9U9 (VPS37C subunit of ESCRT-I OS=Ictidomys tridecemlineatus OX=43179 GN=VPS37C PE=4 SV=1)

HSP 1 Score: 78.1814 bits (191), Expect = 1.291e-12
Identity = 44/128 (34.38%), Postives = 76/128 (59.38%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLL-LAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S ++  +Q  +E  L  N  +A +N E++  L   + NL ++Y  LR++ +  ++ ++KLE +   F P  ++ LL + GM + EE+SE  AE F+     +EKF+E+F   R L H RR++V++LQD
Sbjct:   29 SPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDKYQELRRLVERCQEQKAKLEKFSSAFQPGTLLDLLQIEGM-KIEEESEAMAEKFLEGEVPLEKFLEDFSSMRMLSHLRRVRVEKLQD 155

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. TrEMBL
Match: H3AJ11 (VPS37 C-terminal domain-containing protein OS=Latimeria chalumnae OX=7897 GN=VPS37C PE=4 SV=1)

HSP 1 Score: 77.7962 bits (190), Expect = 1.678e-12
Identity = 43/130 (33.08%), Postives = 75/130 (57.69%), Query Frame = 1

Query:  241 INTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            +  SS++ ++Q  +E  L  N  +A +N E++P L   K  L   Y  L+ I +  ++ R+KLE +        ++ LL    A+ EE+SE+ AENF+     +EKF+E +  KR L H+RR+++++LQ+
Sbjct:   44 VQESSEVQNIQLEQEMALATNRSLAEQNLEFQPRLESGKACLSERYQELQGICESCKESRAKLEEFSAMLDLGTMLALLQTEGAKMEEESEQVAENFLEGMVPLEKFLEEYGVKRKLAHQRRVRIEKLQE 173

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Cavefish
Match: si:ch211-284f22.3 (vacuolar protein sorting-associated protein 37D-like [Source:NCBI gene;Acc:103041644])

HSP 1 Score: 67.781 bits (164), Expect = 1.249e-12
Identity = 39/121 (32.23%), Postives = 66/121 (54.55%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            +Q  +E LL+ N  +A ++  + P L++ K  L  +Y  L K+     + +S+LE +  K SP     LL   +A +EEQSE+  E FM     +E F+++F   R  YH RR + +++Q+
Sbjct:   46 LQVDRETLLVTNRSLAEESLAHRPRLQNGKLQLATKYQELAKLTTACREKQSRLEGHMKKHSPQTAQNLLQEEVARAEEQSEELLERFMEGQVPLEGFLDSFQSFRKTYHIRRAQAEKIQE 166

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Cavefish
Match: zgc:114173 (vacuolar protein sorting-associated protein 37B-like [Source:NCBI gene;Acc:103026711])

HSP 1 Score: 60.4622 bits (145), Expect = 2.527e-10
Identity = 42/147 (28.57%), Postives = 76/147 (51.70%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQDXXXXXXXXXXXXXXXYQQPFISNSKS 708
            +Q+ KE  L  N  +A +N   +P L   K  L   Y  L+++ +  +  +S L+    K S + ++ LL A  A+ EE++E  A++F+     ++ FIE +  KR L H RR+K+D+LQ+++         + +   QP  +N  +
Sbjct:   45 VQQCKEMTLASNRSLAEQNLGLQPDLDQQKMRLTKRYCCLQELYESYQLRKSTLDHSSGKSSLDTLLALLQAEGAKIEEETENLADSFLDGDLSLDSFIEAYQSKRKLAHLRRVKIDKLQEMVIRYFQMPQASVTEPGQPLAANPPA 191

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Cavefish
Match: vps37c (vacuolar protein sorting-associated protein 37C-like [Source:NCBI gene;Acc:103037835])

HSP 1 Score: 56.225 bits (134), Expect = 1.019e-8
Identity = 34/127 (26.77%), Postives = 68/127 (53.54%), Query Frame = 1

Query:  250 SSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            S +I ++Q  +E  L  N  +A +N + +P L   ++ L+ +Y  L ++++  +   +  +    + SP  +   L    A +E +SE  A+ F+  S  +E F+E F   R+L H+RR+ +++LQ+
Sbjct:   29 SDEIQNIQLEREMALASNRSLAEQNLDMKPQLERERERLVEKYAELEEVREKYKQHCALRDGIMGQVSPEGLFCRLQVEGASTEAESETLADEFLEGSLSLESFLERFHSLRSLAHKRRVSIEKLQE 155

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Cavefish
Match: vps37b (VPS37B subunit of ESCRT-I [Source:NCBI gene;Acc:103038428])

HSP 1 Score: 53.5286 bits (127), Expect = 7.077e-8
Identity = 37/120 (30.83%), Postives = 64/120 (53.33%), Query Frame = 1

Query:  271 QKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            Q+ KE  L  N  +A +N E +P L   K  L   Y  L+   +  +  +S L+      S + ++ LL A  A+ EE++E  A++F+     ++ FI+ +  KR L H RR+K+++LQ+
Sbjct:   40 QQSKEMTLASNRSLAEQNLELQPQLDHQKNELTKRYRCLQDKFEAYQLRKSTLDHKSGSSSLDTLLALLQAEGAKIEEETEIMADSFLDGDVTLDTFIDEYQSKRKLAHLRRVKIEKLQE 159

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Sea Lamprey
Match: vps37b (VPS37B subunit of ESCRT-I [Source:ZFIN;Acc:ZDB-GENE-060526-254])

HSP 1 Score: 64.3142 bits (155), Expect = 4.536e-12
Identity = 39/125 (31.20%), Postives = 74/125 (59.20%), Query Frame = 1

Query:  256 QIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            Q+ ++Q  KE  L  N  +A +N + +P L + +  L  +Y  L+ + +   +  +++ES  D    + ++ LL A  A+ E+++EK AE+FM     +E+F++++  KR L H RRIK+++LQ+
Sbjct:    1 QLENIQMEKELCLASNRSLAEENLKQQPQLEEGRLLLAQKYQQLKTLHEAFTEKAARIESRADSQGVDTLLALLQAEGAKIEDETEKMAEHFMEGQLTLEEFVDDYQNKRRLAHMRRIKIEKLQE 125

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Nematostella
Match: EDO31948 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWG3])

HSP 1 Score: 67.0106 bits (162), Expect = 2.000e-13
Identity = 36/123 (29.27%), Postives = 69/123 (56.10%), Query Frame = 1

Query:  256 QIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQL 624
            +I  ++ ++E L   N  +A  N + EP L   +Q LI  ++    +Q   +  ++KL++  D++S +    LL   +A++EE SEK  + F+     +E FI+ F+ ++ L+H RR+K ++L
Sbjct:   52 EIKKIEVNREMLTASNRSLAEFNLKIEPQLNQGRQQLIEAHERREMLQAQFQSNKAKLDTLSDQYSSDTTTALLQTAVAQAEEDSEKTVDTFLDGKMSMEDFIQTFMPQKALHHLRRVKAEKL 174

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Medaka
Match: vps37a (VPS37A subunit of ESCRT-I [Source:NCBI gene;Acc:101170151])

HSP 1 Score: 68.5514 bits (166), Expect = 1.176e-12
Identity = 39/116 (33.62%), Postives = 67/116 (57.76%), Query Frame = 1

Query:  280 KEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQ 627
            KE+L+    D+A KN + EP L D +Q ++N+Y+ L +++   E    +     +  S + +   L     ++EE+SE  AENF+    +I++F+ +F+EKR L H RR K ++LQ
Sbjct:  267 KEELISSIVDMAKKNLQMEPQLEDKRQEMLNKYEQLTQMKTAFEMKMQRQHELSESCSLSTLQARLKVAAHQAEEESEDTAENFLEGGIEIDEFLTSFMEKRTLCHSRRAKEEKLQ 382

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Medaka
Match: vps37b (VPS37B subunit of ESCRT-I [Source:NCBI gene;Acc:101163176])

HSP 1 Score: 57.7658 bits (138), Expect = 2.713e-9
Identity = 36/121 (29.75%), Postives = 72/121 (59.50%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            +Q++KE+ L++N  +A +N   +P+L   K++L   Y  L++  +  +  +S L+      S + ++ LL    A+ EE++E  A++FM     ++ FI+++  KR L H RR+K+++LQ+
Sbjct:   39 VQQNKEKTLVNNRTLAEQNLALQPSLEHKKEDLTKHYRCLQERFESFQLRKSTLDHKSGNTSLDTLLALLQTEGAKIEEETENMADSFMDGEITLDSFIDSYQSKRKLAHLRRVKIEKLQE 159

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Medaka
Match: si:ch211-284f22.3 (vacuolar protein sorting-associated protein 37D [Source:NCBI gene;Acc:105355693])

HSP 1 Score: 51.2174 bits (121), Expect = 4.916e-7
Identity = 36/121 (29.75%), Postives = 63/121 (52.07%), Query Frame = 1

Query:  268 MQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQD 630
            +Q  +E LL  N  +A ++    P L + K  L  +Y  L  +     + +S+L +   K S      LL   +A +EEQSE+  E FM  +  +++F+++F   R  YH RR +V+++Q+
Sbjct:   45 LQVDRETLLTSNRSVAEESLARRPPLNNGKLQLAEKYKELSNLVTTCWEKQSQL-ARGQKHSLQTAQNLLQEEVARAEEQSEELLEKFMEGNVGLDEFLDSFQSSRKTYHIRRAQVEKMQE 164

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Planmine SMEST
Match: SMESG000028338.1 (SMESG000028338.1)

HSP 1 Score: 327.02 bits (837), Expect = 1.186e-113
Identity = 200/200 (100.00%), Postives = 200/200 (100.00%), Query Frame = 1

Query:  127 MYYKTIFPNDDSIMDTVRKNNXXXXXXXXXXXXXXXXXINTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQDXXXXXXXXXXXXXXXYQQPFISNSKSNIGFKF 726
            MYYKTIFPNDDSIMDTVRKNNKEELQKLLDDDEKLLLLINTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQDIINNKTDNNINNYSNYQQPFISNSKSNIGFKF
Sbjct:    1 MYYKTIFPNDDSIMDTVRKNNKEELQKLLDDDEKLLLLINTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQDIINNKTDNNINNYSNYQQPFISNSKSNIGFKF 200

[Close]

BLAST of VPS37C subunit of ESCRT-I vs. Planmine SMEST
Match: SMESG000028338.1 (SMESG000028338.1)

HSP 1 Score: 299.286 bits (765), Expect = 6.463e-103
Identity = 187/187 (100.00%), Postives = 187/187 (100.00%), Query Frame = 1

Query:  166 MDTVRKNNXXXXXXXXXXXXXXXXXINTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQDXXXXXXXXXXXXXXXYQQPFISNSKSNIGFKF 726
            MDTVRKNNKEELQKLLDDDEKLLLLINTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQDIINNKTDNNINNYSNYQQPFISNSKSNIGFKF
Sbjct:    1 MDTVRKNNKEELQKLLDDDEKLLLLINTSSQIVSMQKHKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSKLESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFLEKRNLYHERRIKVDQLQDIINNKTDNNINNYSNYQQPFISNSKSNIGFKF 187

The following BLAST results are available for this feature:

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Human
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Celegans
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Fly
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Zebrafish
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Xenopus
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Mouse
BLAST of VPS37C subunit of ESCRT-I vs. UniProt/SwissProt
BLAST of VPS37C subunit of ESCRT-I vs. TrEMBL
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Cavefish
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Sea Lamprey
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Yeast
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Nematostella
BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Medaka
BLAST of VPS37C subunit of ESCRT-I vs. Planmine SMEST

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
VPS37C	2.460e-14	33.59	VPS37C subunit of ESCRT-I [Source:HGNC Symbol;Acc:...	[more]
VPS37C	6.458e-13	31.67	VPS37C subunit of ESCRT-I [Source:HGNC Symbol;Acc:...	[more]
VPS37B	2.009e-10	31.50	VPS37B subunit of ESCRT-I [Source:HGNC Symbol;Acc:...	[more]
VPS37B	3.958e-9	31.40	VPS37B subunit of ESCRT-I [Source:HGNC Symbol;Acc:...	[more]
VPS37B	4.172e-9	31.40	VPS37B subunit of ESCRT-I [Source:HGNC Symbol;Acc:...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
vps-37	6.441e-8	27.64	Related to yeast Vacuolar Protein Sorting factor ...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Vps37B	3.152e-6	25.95	gene:FBgn0037299 transcript:FBtr0078777	[more]
Vps37B	3.152e-6	25.95	gene:FBgn0037299 transcript:FBtr0305001	[more]
Vps37B	3.152e-6	25.95	gene:FBgn0037299 transcript:FBtr0305002	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
si:ch211-284f22.3	2.323e-11	29.23	si:ch211-284f22.3 [Source:ZFIN;Acc:ZDB-GENE-060526...	[more]
vps37c	8.016e-10	27.56	VPS37C subunit of ESCRT-I [Source:ZFIN;Acc:ZDB-GEN...	[more]
vps37c	8.016e-10	27.56	VPS37C subunit of ESCRT-I [Source:ZFIN;Acc:ZDB-GEN...	[more]
vps37b	1.197e-9	29.23	VPS37B subunit of ESCRT-I [Source:ZFIN;Acc:ZDB-GEN...	[more]
vps37b	1.197e-9	29.23	VPS37B subunit of ESCRT-I [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
vps37b	1.515e-9	30.58	VPS37B, ESCRT-I subunit [Source:NCBI gene;Acc:3946...	[more]
vps37a	1.657e-7	28.45	vacuolar protein sorting 37 homolog A [Source:NCBI...	[more]
vps37a	2.012e-7	28.45	vacuolar protein sorting 37 homolog A [Source:NCBI...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Vps37c	5.410e-15	33.59	vacuolar protein sorting 37C [Source:MGI Symbol;Ac...	[more]
Vps37c	5.410e-15	33.59	vacuolar protein sorting 37C [Source:MGI Symbol;Ac...	[more]
Vps37b	4.324e-9	31.97	vacuolar protein sorting 37B [Source:MGI Symbol;Ac...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8R105\|VP37C_MOUSE	3.784e-14	33.59	Vacuolar protein sorting-associated protein 37C OS...	[more]
sp\|A5D8V6\|VP37C_HUMAN	1.181e-13	33.59	Vacuolar protein sorting-associated protein 37C OS...	[more]
sp\|Q5R9T2\|VP37C_PONAB	6.283e-13	32.81	Vacuolar protein sorting-associated protein 37C OS...	[more]
sp\|Q9H9H4\|VP37B_HUMAN	1.901e-8	31.40	Vacuolar protein sorting-associated protein 37B OS...	[more]
sp\|Q8R0J7\|VP37B_MOUSE	3.025e-8	31.97	Vacuolar protein sorting-associated protein 37B OS...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
G1SMB5	9.346e-13	34.38	VPS37C subunit of ESCRT-I OS=Oryctolagus cuniculus...	[more]
A0A5F9D843	1.063e-12	34.38	VPS37C subunit of ESCRT-I OS=Oryctolagus cuniculus...	[more]
A0A5F9DK27	1.130e-12	34.38	VPS37C subunit of ESCRT-I OS=Oryctolagus cuniculus...	[more]
I3M9U9	1.291e-12	34.38	VPS37C subunit of ESCRT-I OS=Ictidomys tridecemlin...	[more]
H3AJ11	1.678e-12	33.08	VPS37 C-terminal domain-containing protein OS=Lati...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
si:ch211-284f22.3	1.249e-12	32.23	vacuolar protein sorting-associated protein 37D-li...	[more]
zgc:114173	2.527e-10	28.57	vacuolar protein sorting-associated protein 37B-li...	[more]
vps37c	1.019e-8	26.77	vacuolar protein sorting-associated protein 37C-li...	[more]
vps37b	7.077e-8	30.83	VPS37B subunit of ESCRT-I [Source:NCBI gene;Acc:10...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
vps37b	4.536e-12	31.20	VPS37B subunit of ESCRT-I [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO31948	2.000e-13	29.27	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
vps37a	1.176e-12	33.62	VPS37A subunit of ESCRT-I [Source:NCBI gene;Acc:10...	[more]
vps37b	2.713e-9	29.75	VPS37B subunit of ESCRT-I [Source:NCBI gene;Acc:10...	[more]
si:ch211-284f22.3	4.916e-7	29.75	vacuolar protein sorting-associated protein 37D [S...	[more]

BLAST of VPS37C subunit of ESCRT-I vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000028338.1	1.186e-113	100.00	SMESG000028338.1	[more]
SMESG000028338.1	6.463e-103	100.00	SMESG000028338.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30016048 ID=SMED30016048|Name=VPS37C subunit of ESCRT-I|organism=Schmidtea mediterranea sexual|type=transcript|length=914bp
GATGACCAATTAAATCTATTTTTGCAAAAATAAATTCAAAAAATATTTAG
ATTTTAATGGGTTAATTAGAAAATCATTTTTAACATCGTATTAAACTTTG
TTTTATTACAGCAATTGTCATTATTTATGTATTACAAAACTATATTTCCC
AATGATGATTCTATCATGGATACTGTTAGAAAAAATAATAAAGAAGAATT
GCAAAAACTATTAGATGACGATGAAAAGTTGTTGTTGTTAATTAATACTA
GTAGTCAGATAGTTTCCATGCAAAAGCACAAAGAACAGCTACTTTTAGAT
AATTATGACATTGCCAATAAAAATAAAGAATATGAGCCTGCTTTACGGGA
TTTTAAACAAAATTTAATAAATGAATATGATAATCTAAGGAAAATACAAC
AAATGAATGAAGATCTTAGATCCAAATTAGAGTCTTATGAAGATAAATTT
TCACCAAATAATATAGTAACCCTATTATTGGCTGGTATGGCAGAATCGGA
AGAGCAATCTGAGAAATGTGCTGAAAATTTCATGCTTAAATCTACTGATA
TTGAAAAATTTATAGAAAATTTTCTTGAAAAACGAAATTTATATCATGAG
CGAAGAATAAAAGTTGATCAATTGCAGGATATAATTAATAACAAAACAGA
CAATAATATAAATAATTATTCAAACTATCAACAACCATTTATTTCTAATT
CTAAGTCAAATATTGGATTTAAATTCTAAAATTTTCTTGTTTGACAATAT
AAAACAGTTCTTGTAGTTTTGAATAATTACATTTATGTTACAAGTTCATT
TTATATAGCATATAACATTCTGAAAATCTTGTATGTGGTGATATAATATT
TTTAGAGTTATAAACTTATTGATTGTTTAATATTGTTGAAGATCAATAAA
AAAAATTGGTTTTC

protein sequence of SMED30016048-orf-1

>SMED30016048-orf-1 ID=SMED30016048-orf-1|Name=SMED30016048-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=201bp
MYYKTIFPNDDSIMDTVRKNNKEELQKLLDDDEKLLLLINTSSQIVSMQK
HKEQLLLDNYDIANKNKEYEPALRDFKQNLINEYDNLRKIQQMNEDLRSK
LESYEDKFSPNNIVTLLLAGMAESEEQSEKCAENFMLKSTDIEKFIENFL
EKRNLYHERRIKVDQLQDIINNKTDNNINNYSNYQQPFISNSKSNIGFKF
*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0000813	ESCRT I complex

Vocabulary: **biological process**
Term	Definition
GO:0015031	protein transport
GO:0032509	endosome transport via multivesicular body sorting pathway

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000070	intestinal phagocyte

Vocabulary: **INTERPRO**
Term	Definition
IPR029012	Helix_hairpin_bin_sf
IPR037859	Vps37
IPR037202	ESCRT_assembly_dom
IPR009851	Mod_r

Vocabulary: **molecular function**
Term	Definition
GO:0005199	structural constituent of cell wall

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 87..107
IPR009851	Modifier of rudimentary, Modr	PFAM	PF07200	Mod_r	coord: 21..162 e-value: 6.2E-30 score: 104.2
IPR009851	Modifier of rudimentary, Modr	PROSITE	PS51314	VPS37_C	coord: 91..180 score: 22.502
IPR029012	Helix hairpin bin domain superfamily	GENE3D	G3DSA:1.10.287.660		coord: 91..169 e-value: 8.5E-6 score: 27.8
IPR037859	Vacuolar protein sorting-associated protein 37	PANTHER	PTHR13678	WILLIAMS-BEUREN SYNDROME CRITICAL REGION PROTEIN-RELATED	coord: 11..176
IPR037202	ESCRT assembly domain	SUPERFAMILY	SSF140111	Endosomal sorting complex assembly domain	coord: 107..164

Main menu

VPS37C subunit of ESCRT-I

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Owlery

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