Ran GTPase-activating protein 1

Overview


Name	Ran GTPase-activating protein 1
Smed ID	SMED30015929
Length (bp)	2215

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Ran GTPase-activating protein 1 (SMED30015929) t-SNE clustered cells

Violin plots show distribution of expression levels for Ran GTPase-activating protein 1 (SMED30015929) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Ran GTPase-activating protein 1 (SMED30015929) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Ran GTPase-activating protein 1 (SMED30015929) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30015929

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30015929	SMESG000061064.1	SmedASXL_010114	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
neoblast	SMED30015929	SMESG000061064.1	dd_Smed_v4_7553_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
ovary	SMED30015929	SMESG000061064.1	DN312988	ncbi_smed_ests	PMID:16344473 Zayas et al., 2005
testis	SMED30015929	SMESG000061064.1	DN312988	ncbi_smed_ests	PMID:16344473 Zayas et al., 2005

Note: Hover over icons to view figure legend

Homology

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Human
Match: RANGAP1 (Ran GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:9854])

HSP 1 Score: 194.512 bits (493), Expect = 7.798e-53
Identity = 120/329 (36.47%), Postives = 193/329 (58.66%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT ED + V+K++ E+ + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL++EI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL SS C+TL+ L +NN G+G  G + L  AL +    S+ +G  + L+VF+AGRNRLEN G   L E F   + +L+++ + QNGI   GI     L  +   +  L+V+N++DNT   +G   +++ L     +E +  GDCL+++ G   +   +      LK +++S  EI    A+     + + K  +E +DL  N + +    +++E+L
Sbjct:   23 LSFKGKSLKLNTAEDAKDVIKEI-EDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRV-IGTLEEVHMPQNGINHPGITA---LAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMAD-KAELEKLDLNGNTLGEEGCEQLQEVL 345

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Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT ED + V+K++ E+ + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL++EI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL SS C+TL+ L +NN G+G  G + L  AL +    S+ +G  + L+VF+AGRNRLEN G   L E F   + +L+++ + QNGI   GI     L  +   +  L+V+N++DNT   +G   +++ L     +E +  GDCL+++ G   +   +      LK +++S  EI    A+     + + K  +E +DL  N + +    +++E+L
Sbjct:   23 LSFKGKSLKLNTAEDAKDVIKEI-EDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRV-IGTLEEVHMPQNGINHPGITA---LAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMAD-KAELEKLDLNGNTLGEEGCEQLQEVL 345

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Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT ED + V+K++ E+ + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL++EI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL SS C+TL+ L +NN G+G  G + L  AL +    S+ +G  + L+VF+AGRNRLEN G   L E F   + +L+++ + QNGI   GI     L  +   +  L+V+N++DNT   +G   +++ L     +E +  GDCL+++ G   +   +      LK +++S  EI    A+     + + K  +E +DL  N + +    +++E+L
Sbjct:   23 LSFKGKSLKLNTAEDAKDVIKEI-EDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRV-IGTLEEVHMPQNGINHPGITA---LAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMAD-KAELEKLDLNGNTLGEEGCEQLQEVL 345

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Human
Match: RANGAP1 (Ran GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:9854])

HSP 1 Score: 117.857 bits (294), Expect = 4.922e-29
Identity = 85/288 (29.51%), Postives = 142/288 (49.31%), Query Frame = 2

Query:  224 LGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            +GV AA  + + L  ++++++  W+D+FTGRL++EI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL SS C+TL+ L +NN G+G  G + +                                             +L+++ + QNGI   GI     L  +   +  L+V+N++DNT   +G   +++ L     +E +  GDCL+++ G   +   +      LK +++S  EI    A+     + + K  +E +DL  N + +    +++E+L
Sbjct:    2 VGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKVI--------------------------------------------GTLEEVHMPQNGINHPGITA---LAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMAD-KAELEKLDLNGNTLGEEGCEQLQEVL 241

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Human
Match: RANGAP1 (Ran GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:9854])

HSP 1 Score: 105.145 bits (261), Expect = 7.044e-26
Identity = 52/110 (47.27%), Postives = 77/110 (70.00%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVG 436
            LS+ G   + NT ED + V+K++ E+ + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL++EI  AL SL  GL+ A   LVELDLSDNAFGP+GV G
Sbjct:   23 LSFKGKSLKLNTAEDAKDVIKEI-EDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQG 131

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Celegans
Match: ran-2 (Ran GTPase-activating protein 2 [Source:UniProtKB/Swiss-Prot;Acc:P34342])

HSP 1 Score: 181.415 bits (459), Expect = 1.957e-47
Identity = 113/291 (38.83%), Postives = 168/291 (57.73%), Query Frame = 2

Query:  137 NTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQG---CRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLN-QMSLNLKTVSVSGNEITGHCAIKFISK 997
            +T E  E VVK +    + +  L+L GNTLG+ A   + + L +  ++++ +W+DLFTGRLK+EI   L +L   +M A   + ELDLSDNAFGP G   + +LL S   ++L+ L +NN GLG  G    + L + L+K+        + L+ FIAGRNRLEN G   L   F   + +++   + QNGI   GI+    L+ +LK++ NL+ L + DNT+ P+G K L+K L  +  LE L L DCLI+++G  ++   LN Q   +LK V + GNE+T   A   I K
Sbjct:  423 DTAESAEPVVKVIAA-ASSMKALELRGNTLGIAAGNVIAKALESHPELERCLWSDLFTGRLKNEIPPILEALGKAMMTAGCKIKELDLSDNAFGPIGADALKDLLESPSSFSLEVLKLNNNGLGIGGKQIAKSLTECLRKSIAVGGENRLRLKTFIAGRNRLENPGAHALAATFK-ALETVEWFDVRQNGIHEEGIRA---LVAALKHNRNLRYLWLEDNTVLPKGAKALAKTLESWPKLEVLNLSDCLIRDAGCNYIIDHLNPQHHRHLKNVYLCGNELTPPVAKLLIQK 708

HSP 2 Score: 152.14 bits (383), Expect = 6.716e-38
Identity = 106/295 (35.93%), Postives = 166/295 (56.27%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQG-------CRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLN-LKTVSVSGNEIT 967
            LS+ G Q + +TEE+I  V+  + +++N +  L   GNTL V A + + E L  + ++++ IW+D+FTGRLK EI + L +L   L  +   L  LDLSDNAFG      +   L S   Y+L+ L +NN GLG  G       C  L+DA KKA        + L+ F+ GRNRLE      L++ F   + +L++I L QNGI   GI     L  + + +  L++++I+DN   PEG  ++S++L   + +E L LGDC+  + G+  +   L++++ + LK V +SGN IT
Sbjct:    7 LSFFGKQLKLDTEEEISKVIDQIRKHLN-LEVLDFRGNTLSVLAGKLIAESLKTRRELKECIWSDMFTGRLKDEIPLVLDALGEALTASGCRLTTLDLSDNAFGAGLSTSLYNFLQSPALYSLENLILNNNGLGLAGKTVGKALC-SLIDASKKAGTP-----LKLKKFVCGRNRLEVESTIALSDAFIK-LGTLEEIRLPQNGIRDDGIIA---LAEAFRMNKKLRIIDINDNFCCPEGAIQISEVLSDLQFIEVLDLGDCVCDDPGVLAIIAELDKINRDCLKKVVLSGNNIT 290

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Celegans
Match: ran-2 (Ran GTPase-activating protein 2 [Source:UniProtKB/Swiss-Prot;Acc:P34342])

HSP 1 Score: 181.8 bits (460), Expect = 1.961e-47
Identity = 113/291 (38.83%), Postives = 168/291 (57.73%), Query Frame = 2

Query:  137 NTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQG---CRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLN-QMSLNLKTVSVSGNEITGHCAIKFISK 997
            +T E  E VVK +    + +  L+L GNTLG+ A   + + L +  ++++ +W+DLFTGRLK+EI   L +L   +M A   + ELDLSDNAFGP G   + +LL S   ++L+ L +NN GLG  G    + L + L+K+        + L+ FIAGRNRLEN G   L   F   + +++   + QNGI   GI+    L+ +LK++ NL+ L + DNT+ P+G K L+K L  +  LE L L DCLI+++G  ++   LN Q   +LK V + GNE+T   A   I K
Sbjct:  460 DTAESAEPVVKVIAA-ASSMKALELRGNTLGIAAGNVIAKALESHPELERCLWSDLFTGRLKNEIPPILEALGKAMMTAGCKIKELDLSDNAFGPIGADALKDLLESPSSFSLEVLKLNNNGLGIGGKQIAKSLTECLRKSIAVGGENRLRLKTFIAGRNRLENPGAHALAATFK-ALETVEWFDVRQNGIHEEGIRA---LVAALKHNRNLRYLWLEDNTVLPKGAKALAKTLESWPKLEVLNLSDCLIRDAGCNYIIDHLNPQHHRHLKNVYLCGNELTPPVAKLLIQK 745

HSP 2 Score: 152.525 bits (384), Expect = 5.747e-38
Identity = 106/295 (35.93%), Postives = 166/295 (56.27%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQG-------CRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLN-LKTVSVSGNEIT 967
            LS+ G Q + +TEE+I  V+  + +++N +  L   GNTL V A + + E L  + ++++ IW+D+FTGRLK EI + L +L   L  +   L  LDLSDNAFG      +   L S   Y+L+ L +NN GLG  G       C  L+DA KKA        + L+ F+ GRNRLE      L++ F   + +L++I L QNGI   GI     L  + + +  L++++I+DN   PEG  ++S++L   + +E L LGDC+  + G+  +   L++++ + LK V +SGN IT
Sbjct:   44 LSFFGKQLKLDTEEEISKVIDQIRKHLN-LEVLDFRGNTLSVLAGKLIAESLKTRRELKECIWSDMFTGRLKDEIPLVLDALGEALTASGCRLTTLDLSDNAFGAGLSTSLYNFLQSPALYSLENLILNNNGLGLAGKTVGKALC-SLIDASKKAGTP-----LKLKKFVCGRNRLEVESTIALSDAFIK-LGTLEEIRLPQNGIRDDGIIA---LAEAFRMNKKLRIIDINDNFCCPEGAIQISEVLSDLQFIEVLDLGDCVCDDPGVLAIIAELDKINRDCLKKVVLSGNNIT 327

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Fly
Match: RanGAP (gene:FBgn0003346 transcript:FBtr0334175)

HSP 1 Score: 206.838 bits (525), Expect = 1.193e-57
Identity = 122/280 (43.57%), Postives = 170/280 (60.71%), Query Frame = 2

Query:  134 WNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGM-EMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEI 964
            WNT  D++ VV  LN+    V  L L GNTLGV AA+ + E L    + +K +W ++FTGRL SEI  AL  L   L+ A   L  LDLSDNA GPNG+ G+ ELL S  CY+L+ L + N GLG +G   L  AL     N+N  G  + L VFI  RNRLE+AG  EM T F +  + + ++IVL QN I    I+GV+ L  S K++ +L+VLN++DNT+K EG +++++ LP+   L E+  GDCLIK +G  H  + L + +  L+ + +  NEI
Sbjct:   20 WNTAADVQDVVDALNKQTT-VHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAFQT--LKTFEEIVLEQNSI---YIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEI 293

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Fly
Match: RanGAP (gene:FBgn0003346 transcript:FBtr0081234)

HSP 1 Score: 206.838 bits (525), Expect = 1.452e-57
Identity = 122/280 (43.57%), Postives = 169/280 (60.36%), Query Frame = 2

Query:  134 WNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGM-EMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEI 964
            WNT  D++ VV  LN+    V  L L GNTLGV AA+ + E L    + +K +W ++FTGRL SEI  AL  L   L+ A   L  LDLSDNA GPNG+ G+ ELL S  CY+L+ L + N GLG +G   L  AL     N+N  G  + L VFI  RNRLE+AG  EM T F    + + ++IVL QN I    I+GV+ L  S K++ +L+VLN++DNT+K EG +++++ LP+   L E+  GDCLIK +G  H  + L + +  L+ + +  NEI
Sbjct:   28 WNTAADVQDVVDALNKQTT-VHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAF--QTLKTFEEIVLEQNSI---YIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEI 301

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Fly
Match: RanGAP (gene:FBgn0003346 transcript:FBtr0334174)

HSP 1 Score: 206.838 bits (525), Expect = 1.452e-57
Identity = 122/280 (43.57%), Postives = 169/280 (60.36%), Query Frame = 2

Query:  134 WNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGM-EMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEI 964
            WNT  D++ VV  LN+    V  L L GNTLGV AA+ + E L    + +K +W ++FTGRL SEI  AL  L   L+ A   L  LDLSDNA GPNG+ G+ ELL S  CY+L+ L + N GLG +G   L  AL     N+N  G  + L VFI  RNRLE+AG  EM T F    + + ++IVL QN I    I+GV+ L  S K++ +L+VLN++DNT+K EG +++++ LP+   L E+  GDCLIK +G  H  + L + +  L+ + +  NEI
Sbjct:   28 WNTAADVQDVVDALNKQTT-VHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAF--QTLKTFEEIVLEQNSI---YIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEI 301

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Zebrafish
Match: rangap1a (RAN GTPase activating protein 1a [Source:ZFIN;Acc:ZDB-GENE-060929-492])

HSP 1 Score: 199.904 bits (507), Expect = 3.406e-55
Identity = 122/341 (35.78%), Postives = 201/341 (58.94%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAE---HDKLDAL 1114
            LSY G   + +  + +E +VK++ E    +  L+L GNT+GV AA+ + + L N++ +Q   W+D+FTGRL++EI  AL SL   L+ A   L  LDLSDNAFGP+GV G+ +LL S+ C+TL+ L +NN G+G  G + L  AL +    S+  G    L+VFIAGRNRLEN G   L + F   M SL+++ + QNGI   G+     L  +++++  L+VLN++DNT   +G   +++ L +  +++ +  GDCL+++ G   L + + +    LK +++S  EI    A++ +++ V+ K   E +DL  N + +     +K+++      DKL +L
Sbjct:   23 LSYKGKGLKLDNAQSVEQMVKEIGE-FEGLRALRLEGNTIGVEAAQTIAKALENKSDLQCCHWSDMFTGRLRAEIPPALVSLGDALILAGARLKVLDLSDNAFGPDGVKGIEKLLKSAACHTLQELRLNNCGMGIGGGKILAAALSECHQQSSALGAPFKLKVFIAGRNRLENDGATALAQAFQL-MGSLEEVHMPQNGINYPGVTA---LATAMQHNPQLRVLNLNDNTFTKKGAMAMAQALKHLRNVQVINFGDCLVRSEGASALAETVREGLPILKELNLSFGEIMEEAALE-VAQSVQHKDQFEKLDLNGNSLGEDGCKSLKQLMESINMADKLGSL 357

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Zebrafish
Match: rangap1b (Ran GTPase activating protein 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1921])

HSP 1 Score: 195.282 bits (495), Expect = 1.956e-53
Identity = 126/338 (37.28%), Postives = 198/338 (58.58%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDAL 1114
            LSY G   + +  E ++ +V+D+ E    + +L+L GNTLGV AA+ + + L  + ++++  W+D+FTGRL+SEI  AL SL   LM +   L +LDLSDNAFGP+GV G+  LL SS CYTL+ L +NN G+G  G   L  AL +    S+     + L+VFIAGRNRLEN G   L + F   + SL+++ + QNGI   GI     L  +LK++ NL+VLN++DNT   +G K +++ + + + L+ +  GDCL+++ G   +   L +    L+ +++S  EI    A   ++K V+ K  +E +DL  N   +     +KE + + +  D L
Sbjct:   23 LSYKGRGLKLDNAESVKEIVEDI-ERCQGLQSLRLEGNTLGVEAADAIAKSLEAKRELEQCHWSDMFTGRLRSEIPPALKSLGNALMTSGARLTQLDLSDNAFGPDGVKGIENLLKSSACYTLQELRLNNCGMGSGGGVVLASALTECHKQSSAAASPLRLKVFIAGRNRLENDGATALAKAFKL-LGSLEEVHMPQNGINHPGITA---LAAALKHNPNLQVLNLNDNTFTTKGSKAMAEAIRHLQCLKAINFGDCLVRSEGAIAIAGALREGLHLLRELNLSFGEIC-EAAAMVVAKAVQGKADLEKLDLNGNCFGEDGCEALKEAMEKMNMEDLL 354

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Zebrafish
Match: rangap1b (Ran GTPase activating protein 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1921])

HSP 1 Score: 195.282 bits (495), Expect = 2.129e-53
Identity = 126/338 (37.28%), Postives = 198/338 (58.58%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDAL 1114
            LSY G   + +  E ++ +V+D+ E    + +L+L GNTLGV AA+ + + L  + ++++  W+D+FTGRL+SEI  AL SL   LM +   L +LDLSDNAFGP+GV G+  LL SS CYTL+ L +NN G+G  G   L  AL +    S+     + L+VFIAGRNRLEN G   L + F   + SL+++ + QNGI   GI     L  +LK++ NL+VLN++DNT   +G K +++ + + + L+ +  GDCL+++ G   +   L +    L+ +++S  EI    A   ++K V+ K  +E +DL  N   +     +KE + + +  D L
Sbjct:   23 LSYKGRGLKLDNAESVKEIVEDI-ERCQGLQSLRLEGNTLGVEAADAIAKSLEAKRELEQCHWSDMFTGRLRSEIPPALKSLGNALMTSGARLTQLDLSDNAFGPDGVKGIENLLKSSACYTLQELRLNNCGMGSGGGVVLASALTECHKQSSAAASPLRLKVFIAGRNRLENDGATALAKAFKL-LGSLEEVHMPQNGINHPGITA---LAAALKHNPNLQVLNLNDNTFTTKGSKAMAEAIRHLQCLKAINFGDCLVRSEGAIAIAGALREGLHLLRELNLSFGEIC-EAAAMVVAKAVQGKADLEKLDLNGNCFGEDGCEALKEAMEKMNMEDLL 354

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Zebrafish
Match: rangap1b (Ran GTPase activating protein 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1921])

HSP 1 Score: 159.073 bits (401), Expect = 6.459e-44
Identity = 94/220 (42.73%), Postives = 135/220 (61.36%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHIN 760
            LSY G   + +  E ++ +V+D+ E    + +L+L GNTLGV AA+ + + L  + ++++  W+D+FTGRL+SEI  AL SL   LM +   L +LDLSDNAFGP+GV G+  LL SS CYTL+ L +NN G+G  G   L  AL +    S+     + L+VFIAGRNRLEN G   L + F   + SL+++ + QNGI   GI     L  +LK++ N
Sbjct:   23 LSYKGRGLKLDNAESVKEIVEDI-ERCQGLQSLRLEGNTLGVEAADAIAKSLEAKRELEQCHWSDMFTGRLRSEIPPALKSLGNALMTSGARLTQLDLSDNAFGPDGVKGIENLLKSSACYTLQELRLNNCGMGSGGGVVLASALTECHKQSSAAASPLRLKVFIAGRNRLENDGATALAKAFKL-LGSLEEVHMPQNGINHPGITA---LAAALKHNPN 237

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Zebrafish
Match: si:ch211-156p11.1 (si:ch211-156p11.1 [Source:ZFIN;Acc:ZDB-GENE-070912-120])

HSP 1 Score: 78.9518 bits (193), Expect = 1.675e-14
Identity = 94/358 (26.26%), Postives = 170/358 (47.49%), Query Frame = 2

Query:  140 TEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVA---LSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGN--------EITG-----HCAIK--------------FISKIV-ETKHIIESIDLTENEIKKVALNEIKEILAE-HDKLDALV 1117
            TEE    +   L  + + +  L LS N L  +  ++L + L  ++K++KL +         SE S++     +L+  L     HL+ELDL  N  G +GV  +T+LL    C TLKTL+++N  +  +    L  ALK     S+ + +NL       N++ N G+ ++ +   D    LK++ L +  +       + +++ S  +  +LK L++S+N ++  GVK LS  L   + LE+L L DC I   G + L   L     +L  + + GN        E+T      HC +K              F++ +V E   +++ ++L+E E+    +N++  +L + H +L+ L+
Sbjct:  883 TEESCSALALVLRSDSSSLKDLDLSNNNLQDSGVKRLSDVLK-ESKLEKLGF---------SECSISEEGYKALASALRSNPSHLIELDLRGNDPGQSGVKELTDLLQDPHC-TLKTLSLHNCSITEEHGENLTSALKSNP--SHLRELNL-----SGNQIRNTGVNLVCDVLKDSGCRLKRLRLSKCDLTEESCSALASVLRS--DSSSLKDLDLSNNNLQDSGVKLLSDELKDSK-LEKLSLSDCSISEEGYKALASALRSNPSHLIELDLRGNDPGQSGVKELTDLLQDPHCTLKTLRFLSPAADEFCQFVTGVVGENPLLLKELNLSERELGDTRVNQLSALLQDKHCRLNTLM 1219

HSP 2 Score: 60.8474 bits (146), Expect = 6.859e-9
Identity = 89/305 (29.18%), Postives = 141/305 (46.23%), Query Frame = 2

Query:  140 TEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSN---YKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKIL--PYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISK-IVETKHIIESIDL 1036
            TEE    +   L  + + +  L LS N L  +  + L + L + +K++KL  +D     +  E   AL+S    L     HL+ELDL  N  GP+GV  +T+LL    C TL TL   +     +GC Q V  +    +  N    K +NL     G  R     +  L+    D   +L  ++L    I   G   V + + S  +H  L+ LN+ +N +   GVK LS +L  P F+ L+ L L +C I     E LT  L     NL+ +++S N + G   +K ++  ++ET+  +E + L
Sbjct: 1397 TEESCSALASVLRSDSSSLKNLDLSNNNLQDSGVKLLSDGLKD-SKLEKLSLSDC---SISEEGYKALAS---ALRSNPSHLIELDLRGNDPGPSGVKELTDLLQDPHC-TLNTLRFLSPA-ADEGC-QFVTGI----VGENPLLLKELNLSDRELGDTR-----VNQLSALLQDKHCTLNTLMLSSCKITDEGYSAVTSALKSNPSH--LRELNLRENKLGGFGVKNLSDLLMKPQFK-LKILDLYNCSITEEQCEILTSALKSNPTNLRELNLSWNNL-GDSGVKNLNNLLMETQFKLEKLHL 1678

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Xenopus
Match: tcf7l1 (transcription factor 7 like 1 [Source:Xenbase;Acc:XB-GENE-1031985])

HSP 1 Score: 195.282 bits (495), Expect = 3.107e-53
Identity = 121/329 (36.78%), Postives = 195/329 (59.27%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKA--RINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT +D E V++++ E+   +  L+L GNT+G+ AA+ + + L  +  +++  W+D+FTGRL+SEI  +L SL   L+ A   L ELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +   + +S+ K + L+VFIAGRNRLEN G   L E F   + +L+++ + QNGI   GI     L  S K +  LKV+N++DNT   +G   +++ L     +E +  GDCL+++ G + +   L +    LK +++S  EI    A+  +++ VE +  ++ +DL  N + +    +++EIL
Sbjct:   40 LSFKGKSLKLNTAQDAEEVIREI-EDFEGLHALRLEGNTVGLEAAKAIAKVLEKKPDLKRCHWSDMFTGRLRSEIPPSLISLGDALITAGAQLTELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECYKKSSSHGKPLALKVFIAGRNRLENDGATALAEAFRL-IGTLEEVHMPQNGINHAGITA---LAESFKANSLLKVINLNDNTFTEKGGIAMAEALKTLRQVEVINFGDCLVRSKGAQAIATALKEGLHKLKELNLSFCEIKRDAAV-VLAESVEDRSELQKLDLNGNCLGEGGCEQVQEIL 362

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Xenopus
Match: tcf7l1 (transcription factor 7 like 1 [Source:Xenbase;Acc:XB-GENE-1031985])

HSP 1 Score: 194.897 bits (494), Expect = 4.373e-53
Identity = 121/329 (36.78%), Postives = 195/329 (59.27%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKA--RINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT +D E V++++ E+   +  L+L GNT+G+ AA+ + + L  +  +++  W+D+FTGRL+SEI  +L SL   L+ A   L ELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +   + +S+ K + L+VFIAGRNRLEN G   L E F   + +L+++ + QNGI   GI     L  S K +  LKV+N++DNT   +G   +++ L     +E +  GDCL+++ G + +   L +    LK +++S  EI    A+  +++ VE +  ++ +DL  N + +    +++EIL
Sbjct:   24 LSFKGKSLKLNTAQDAEEVIREI-EDFEGLHALRLEGNTVGLEAAKAIAKVLEKKPDLKRCHWSDMFTGRLRSEIPPSLISLGDALITAGAQLTELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECYKKSSSHGKPLALKVFIAGRNRLENDGATALAEAFRL-IGTLEEVHMPQNGINHAGITA---LAESFKANSLLKVINLNDNTFTEKGGIAMAEALKTLRQVEVINFGDCLVRSKGAQAIATALKEGLHKLKELNLSFCEIKRDAAV-VLAESVEDRSELQKLDLNGNCLGEGGCEQVQEIL 346

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Xenopus
Match: tcf7l1 (transcription factor 7 like 1 [Source:Xenbase;Acc:XB-GENE-1031985])

HSP 1 Score: 194.126 bits (492), Expect = 4.963e-53
Identity = 121/329 (36.78%), Postives = 195/329 (59.27%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKA--RINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT +D E V++++ E+   +  L+L GNT+G+ AA+ + + L  +  +++  W+D+FTGRL+SEI  +L SL   L+ A   L ELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +   + +S+ K + L+VFIAGRNRLEN G   L E F   + +L+++ + QNGI   GI     L  S K +  LKV+N++DNT   +G   +++ L     +E +  GDCL+++ G + +   L +    LK +++S  EI    A+  +++ VE +  ++ +DL  N + +    +++EIL
Sbjct:   24 LSFKGKSLKLNTAQDAEEVIREI-EDFEGLHALRLEGNTVGLEAAKAIAKVLEKKPDLKRCHWSDMFTGRLRSEIPPSLISLGDALITAGAQLTELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECYKKSSSHGKPLALKVFIAGRNRLENDGATALAEAFRL-IGTLEEVHMPQNGINHAGITA---LAESFKANSLLKVINLNDNTFTEKGGIAMAEALKTLRQVEVINFGDCLVRSKGAQAIATALKEGLHKLKELNLSFCEIKRDAAV-VLAESVEDRSELQKLDLNGNCLGEGGCEQVQEIL 346

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Xenopus
Match: tcf7l1 (transcription factor 7 like 1 [Source:Xenbase;Acc:XB-GENE-1031985])

HSP 1 Score: 189.504 bits (480), Expect = 1.835e-51
Identity = 117/312 (37.50%), Postives = 186/312 (59.62%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKA--RINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDL 1036
            LS+ G   + NT +D E V++++ E+   +  L+L GNT+G+ AA+ + + L  +  +++  W+D+FTGRL+SEI  +L SL   L+ A   L ELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +   + +S+ K + L+VFIAGRNRLEN G   L E F   + +L+++ + QNGI   GI     L  S K +  LKV+N++DNT   +G   +++ L     +E +  GDCL+++ G + +   L +    LK +++S  EI    A+  +++ VE +  ++ +DL
Sbjct:   24 LSFKGKSLKLNTAQDAEEVIREI-EDFEGLHALRLEGNTVGLEAAKAIAKVLEKKPDLKRCHWSDMFTGRLRSEIPPSLISLGDALITAGAQLTELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECYKKSSSHGKPLALKVFIAGRNRLENDGATALAEAFRL-IGTLEEVHMPQNGINHAGITA---LAESFKANSLLKVINLNDNTFTEKGGIAMAEALKTLRQVEVINFGDCLVRSKGAQAIATALKEGLHKLKELNLSFCEIKRDAAV-VLAESVEDRSELQKLDL 329

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Xenopus
Match: tcf7l1 (transcription factor 7 like 1 [Source:Xenbase;Acc:XB-GENE-1031985])

HSP 1 Score: 107.842 bits (268), Expect = 3.704e-24
Identity = 66/193 (34.20%), Postives = 106/193 (54.92%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVL 685
            LS+ G   + NT +D E V++++ E+   +  L+L GNT+G+ AA+ + + L  +  +++  W+D+FTGRL+SEI  +L SL   L+ A   L ELDLSDNAFGP+GV G   LL S        +N+N+     +G   + +ALK  R         +EV   G   + + G + +     +G+  LK++ L
Sbjct:   24 LSFKGKSLKLNTAQDAEEVIREI-EDFEGLHALRLEGNTVGLEAAKAIAKVLEKKPDLKRCHWSDMFTGRLRSEIPPSLISLGDALITAGAQLTELDLSDNAFGPDGVRGFEALLKSPAL-----INLNDNTFTEKGGIAMAEALKTLR--------QVEVINFGDCLVRSKGAQAIATALKEGLHKLKELNL 202

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Mouse
Match: Rangap1 (RAN GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:103071])

HSP 1 Score: 189.504 bits (480), Expect = 3.363e-51
Identity = 120/329 (36.47%), Postives = 192/329 (58.36%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT ED + V+K++ E  + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL+SEI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +    S+ +G  + L+VF+AGRNRLEN G   L E F   + +L+++ + QNGI  H   GV  L  +   +  L+V+N++DNT   +G   +++ L     +E +  GDCL+++ G   +   +      LK +++S  EI    A+     + + K  +E +DL  N + +    +++E++
Sbjct:   23 LSFKGKGLKLNTAEDAKDVIKEIEE-FDGLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGI-IGTLEEVHMPQNGIN-H--PGVTALAQAFAINPLLRVINLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVAD-KAELEKLDLNGNALGEEGCEQLQEVM 345

[Close]

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT ED + V+K++ E  + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL+SEI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +    S+ +G  + L+VF+AGRNRLEN G   L E F   + +L+++ + QNGI  H   GV  L  +   +  L+V+N++DNT   +G   +++ L     +E +  GDCL+++ G   +   +      LK +++S  EI    A+     + + K  +E +DL  N + +    +++E++
Sbjct:   23 LSFKGKGLKLNTAEDAKDVIKEIEE-FDGLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGI-IGTLEEVHMPQNGIN-H--PGVTALAQAFAINPLLRVINLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVAD-KAELEKLDLNGNALGEEGCEQLQEVM 345

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Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT ED + V+K++ E  + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL+SEI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +    S+ +G  + L+VF+AGRNRLEN G   L E F   + +L+++ + QNGI  H   GV  L  +   +  L+V+N++DNT   +G   +++ L     +E +  GDCL+++ G   +   +      LK +++S  EI    A+     + + K  +E +DL  N + +    +++E++
Sbjct:   23 LSFKGKGLKLNTAEDAKDVIKEIEE-FDGLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGI-IGTLEEVHMPQNGIN-H--PGVTALAQAFAINPLLRVINLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVAD-KAELEKLDLNGNALGEEGCEQLQEVM 345

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Mouse
Match: Rangap1 (RAN GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:103071])

HSP 1 Score: 170.244 bits (430), Expect = 1.233e-47
Identity = 101/235 (42.98%), Postives = 148/235 (62.98%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEG 805
            LS+ G   + NT ED + V+K++ E  + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL+SEI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +    S+ +G  + L+VF+AGRNRLEN G   L E F   + +L+++ + QNGI  H   GV  L  +   +  L+V+N++DNT   +G
Sbjct:   23 LSFKGKGLKLNTAEDAKDVIKEIEE-FDGLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGI-IGTLEEVHMPQNGIN-H--PGVTALAQAFAINPLLRVINLNDNTFTEKG 252

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Mouse
Match: Rangap1 (RAN GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:103071])

HSP 1 Score: 117.087 bits (292), Expect = 4.066e-30
Identity = 59/123 (47.97%), Postives = 83/123 (67.48%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTL 475
            LS+ G   + NT ED + V+K++ E  + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL+SEI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL S  C+TL
Sbjct:   23 LSFKGKGLKLNTAEDAKDVIKEIEE-FDGLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTL 144

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BLAST of Ran GTPase-activating protein 1 vs. UniProt/SwissProt
Match: sp|Q9VIW3|RAGP1_DROME (Ran GTPase-activating protein OS=Drosophila melanogaster OX=7227 GN=RanGAP PE=1 SV=1)

HSP 1 Score: 206.838 bits (525), Expect = 1.455e-56
Identity = 122/280 (43.57%), Postives = 169/280 (60.36%), Query Frame = 2

Query:  134 WNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGM-EMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEI 964
            WNT  D++ VV  LN+    V  L L GNTLGV AA+ + E L    + +K +W ++FTGRL SEI  AL  L   L+ A   L  LDLSDNA GPNG+ G+ ELL S  CY+L+ L + N GLG +G   L  AL     N+N  G  + L VFI  RNRLE+AG  EM T F    + + ++IVL QN I    I+GV+ L  S K++ +L+VLN++DNT+K EG +++++ LP+   L E+  GDCLIK +G  H  + L + +  L+ + +  NEI
Sbjct:   28 WNTAADVQDVVDALNKQTT-VHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAF--QTLKTFEEIVLEQNSI---YIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEI 301

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BLAST of Ran GTPase-activating protein 1 vs. UniProt/SwissProt
Match: sp|O13066|RAGP1_XENLA (Ran GTPase-activating protein 1 OS=Xenopus laevis OX=8355 GN=rangap1 PE=1 SV=1)

HSP 1 Score: 203.371 bits (516), Expect = 2.285e-55
Identity = 125/329 (37.99%), Postives = 192/329 (58.36%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT +D E V++++ E    +  L+L GNT+GV AA+ + E L  +  +++  W+D+FTGRL+ EI  AL SL   L+ A   L ELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +    S+  G  + L+VFIAGRNRLEN G   L+E F   + +L+++ + QNGI   GI     L  S K +  LKV+N++DNT   +G   +++ L     +E +  GDCL+++ G + +   L +    LK +++S  EI    A+  +++ VE K  +E +DL  N + +    +++EIL
Sbjct:   23 LSFKGKTLKLNTAQDAEEVIREIEE-YEGLQALRLEGNTVGVEAAKAIAEVLQRKPDLKRCHWSDMFTGRLRPEIPTALRSLGDALITAGAQLTELDLSDNAFGPDGVRGFEALLKSPTCFTLQELKLNNCGMGIGGGKILAAALTECHKKSSAHGKPLALKVFIAGRNRLENDGATALSEAFRL-IGTLEEVHMPQNGINHAGITA---LAESFKANSLLKVINLNDNTFTEKGGVAMAEALKTLRQVEVINFGDCLVRSKGAQAIASALKEGLHKLKDLNLSYCEIKADAAVS-LAESVEDKSDLEKLDLNGNCLGEEGCEQVQEIL 345

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BLAST of Ran GTPase-activating protein 1 vs. UniProt/SwissProt
Match: sp|P46060|RAGP1_HUMAN (Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 3.745e-52
Identity = 120/329 (36.47%), Postives = 193/329 (58.66%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT ED + V+K++ E+ + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL++EI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL SS C+TL+ L +NN G+G  G + L  AL +    S+ +G  + L+VF+AGRNRLEN G   L E F   + +L+++ + QNGI   GI     L  +   +  L+V+N++DNT   +G   +++ L     +E +  GDCL+++ G   +   +      LK +++S  EI    A+     + + K  +E +DL  N + +    +++E+L
Sbjct:   23 LSFKGKSLKLNTAEDAKDVIKEI-EDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRV-IGTLEEVHMPQNGINHPGITA---LAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMAD-KAELEKLDLNGNTLGEEGCEQLQEVL 345

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BLAST of Ran GTPase-activating protein 1 vs. UniProt/SwissProt
Match: sp|P46061|RAGP1_MOUSE (Ran GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rangap1 PE=1 SV=2)

HSP 1 Score: 189.504 bits (480), Expect = 2.352e-50
Identity = 120/329 (36.47%), Postives = 192/329 (58.36%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LS+ G   + NT ED + V+K++ E  + +  L+L GNT+GV AA  + + L  ++++++  W+D+FTGRL+SEI  AL SL  GL+ A   LVELDLSDNAFGP+GV G   LL S  C+TL+ L +NN G+G  G + L  AL +    S+ +G  + L+VF+AGRNRLEN G   L E F   + +L+++ + QNGI  H   GV  L  +   +  L+V+N++DNT   +G   +++ L     +E +  GDCL+++ G   +   +      LK +++S  EI    A+     + + K  +E +DL  N + +    +++E++
Sbjct:   23 LSFKGKGLKLNTAEDAKDVIKEIEE-FDGLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGI-IGTLEEVHMPQNGIN-H--PGVTALAQAFAINPLLRVINLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVAD-KAELEKLDLNGNALGEEGCEQLQEVM 345

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BLAST of Ran GTPase-activating protein 1 vs. UniProt/SwissProt
Match: sp|P34342|RGP2_CAEEL (Ran GTPase-activating protein 2 OS=Caenorhabditis elegans OX=6239 GN=ran-2 PE=4 SV=3)

HSP 1 Score: 181.8 bits (460), Expect = 2.495e-46
Identity = 113/291 (38.83%), Postives = 168/291 (57.73%), Query Frame = 2

Query:  137 NTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQG---CRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLN-QMSLNLKTVSVSGNEITGHCAIKFISK 997
            +T E  E VVK +    + +  L+L GNTLG+ A   + + L +  ++++ +W+DLFTGRLK+EI   L +L   +M A   + ELDLSDNAFGP G   + +LL S   ++L+ L +NN GLG  G    + L + L+K+        + L+ FIAGRNRLEN G   L   F   + +++   + QNGI   GI+    L+ +LK++ NL+ L + DNT+ P+G K L+K L  +  LE L L DCLI+++G  ++   LN Q   +LK V + GNE+T   A   I K
Sbjct:  460 DTAESAEPVVKVIAA-ASSMKALELRGNTLGIAAGNVIAKALESHPELERCLWSDLFTGRLKNEIPPILEALGKAMMTAGCKIKELDLSDNAFGPIGADALKDLLESPSSFSLEVLKLNNNGLGIGGKQIAKSLTECLRKSIAVGGENRLRLKTFIAGRNRLENPGAHALAATFK-ALETVEWFDVRQNGIHEEGIRA---LVAALKHNRNLRYLWLEDNTVLPKGAKALAKTLESWPKLEVLNLSDCLIRDAGCNYIIDHLNPQHHRHLKNVYLCGNELTPPVAKLLIQK 745

HSP 2 Score: 152.525 bits (384), Expect = 7.311e-37
Identity = 106/295 (35.93%), Postives = 166/295 (56.27%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQG-------CRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLN-LKTVSVSGNEIT 967
            LS+ G Q + +TEE+I  V+  + +++N +  L   GNTL V A + + E L  + ++++ IW+D+FTGRLK EI + L +L   L  +   L  LDLSDNAFG      +   L S   Y+L+ L +NN GLG  G       C  L+DA KKA        + L+ F+ GRNRLE      L++ F   + +L++I L QNGI   GI     L  + + +  L++++I+DN   PEG  ++S++L   + +E L LGDC+  + G+  +   L++++ + LK V +SGN IT
Sbjct:   44 LSFFGKQLKLDTEEEISKVIDQIRKHLN-LEVLDFRGNTLSVLAGKLIAESLKTRRELKECIWSDMFTGRLKDEIPLVLDALGEALTASGCRLTTLDLSDNAFGAGLSTSLYNFLQSPALYSLENLILNNNGLGLAGKTVGKALC-SLIDASKKAGTP-----LKLKKFVCGRNRLEVESTIALSDAFIK-LGTLEEIRLPQNGIRDDGIIA---LAEAFRMNKKLRIIDINDNFCCPEGAIQISEVLSDLQFIEVLDLGDCVCDDPGVLAIIAELDKINRDCLKKVVLSGNNIT 327

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BLAST of Ran GTPase-activating protein 1 vs. TrEMBL
Match: A0A183A5Z9 (Uncharacterized protein OS=Echinostoma caproni OX=27848 PE=4 SV=1)

HSP 1 Score: 293.893 bits (751), Expect = 4.120e-85
Identity = 152/310 (49.03%), Postives = 213/310 (68.71%), Query Frame = 2

Query:  209 LSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSL--NLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDALVEDEAN 1132
            LSGNTLG+ AAE +   L N  K+Q+ +W+DLFTGRLKSEI+ AL  LS G++ +   LVELDLSDNAFGPNGVVGV +L+AS  C TL+ L MNNQGLGH+GCR L +AL+K R +S  +G+ L+VF AGRNRLEN G ++L++ F D M SL+++ L QNGIGIHGI+GVD L+  +K++ NL+VLN+SDN++  +G K ++K L   E+LEEL+L DC+++ SG+  + + L       N++ ++++GNEIT    I  I  +  +K  +E +DL  NE  K  +  I   LA    L  L  ++A+
Sbjct:    1 LSGNTLGITAAEPIGIALENNPKLQRCLWSDLFTGRLKSEIAPALRHLSSGIIASGARLVELDLSDNAFGPNGVVGVVDLIASPACSTLQILRMNNQGLGHEGCRHLTEALQKGRKSSGGRGLLLKVFCAGRNRLENYGAQLLSDVFCD-MGSLEEVALYQNGIGIHGIEGVDALVRMMKHNPNLRVLNLSDNSLTQKGGKAIAKALSSLENLEELHLSDCILRPSGVTAIARALEDPDTLPNIRVLNLTGNEITRSTGISLILSL-GSKSRLEFLDLNANEFGKSGIRAIIRTLASVGLLHVLPVNQAD 308

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BLAST of Ran GTPase-activating protein 1 vs. TrEMBL
Match: A0A3P8G2K2 (Uncharacterized protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS2384 PE=4 SV=1)

HSP 1 Score: 293.123 bits (749), Expect = 7.290e-85
Identity = 151/310 (48.71%), Postives = 213/310 (68.71%), Query Frame = 2

Query:  209 LSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSL--NLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDALVEDEAN 1132
            +SGNTLG+ AAE +   L N  K+Q+ +W+DLFTGRLKSEI+ AL  LS G++ +   LVELDLSDNAFGPNGVVGV +L+AS  C TL+ L MNNQGLGH+GCR L +AL+K R +S  +G+ L+VF AGRNRLEN G ++L++ F D M SL+++ L QNGIGIHGI+GVD L+  +K++ NL+VLN+SDN++  +G K ++K L   E+LEEL+L DC+++ SG+  + + L       N++ ++++GNEIT    I  I  +  +K  +E +DL  NE  K  +  I   LA    L  L  ++A+
Sbjct:    1 MSGNTLGITAAEPIGIALENNPKLQRCLWSDLFTGRLKSEIAPALRHLSSGIIASGARLVELDLSDNAFGPNGVVGVVDLIASPACSTLQILRMNNQGLGHEGCRHLTEALQKGRKSSGGRGLLLKVFCAGRNRLENYGAQLLSDVFCD-MGSLEEVALYQNGIGIHGIEGVDALVRMMKHNPNLRVLNLSDNSLTQKGGKAIAKALSSLENLEELHLSDCILRPSGVTAIARALEDPDTLPNIRVLNLTGNEITRSTGISLILSL-GSKSRLEFLDLNANEFGKSGIRAIIRTLASVGLLHVLPVNQAD 308

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BLAST of Ran GTPase-activating protein 1 vs. TrEMBL
Match: A0A4E0RKC2 (Ran GTPase-activating protein 1 OS=Fasciola hepatica OX=6192 GN=D915_002760 PE=4 SV=1)

HSP 1 Score: 294.664 bits (753), Expect = 9.051e-85
Identity = 155/329 (47.11%), Postives = 223/329 (67.78%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSL--NLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            + ++GL  + +  +D+E +V+ L EN +  +   LSG+TLG+ AAE +   L + TK+Q+ +W+DLFTGRLKSEI+ AL  LS G+M +   LVELDLSDNAFGPNGVVGV +L+AS  C TL+ L MNNQGLGH+GCR LV+AL+K R  S  +G+ L+VF AGRNRLEN G ++L++ FSD M SL+++ L QNGIGIHGI+GV++L+  ++ +  L++LN+SDNT+  +G K ++K L    DLEEL+L DCL++ SG+  L + L    L  N++ ++++GNEI     I  I  +   K  ++ +DL  NE     +  I   L
Sbjct:    6 VDFSGLALKLDEPKDVEKIVEALVENPD-ASCFNLSGSTLGIAAAEPIGIALEHNTKLQRCLWSDLFTGRLKSEIAPALRHLSTGVMASGACLVELDLSDNAFGPNGVVGVVDLIASPACATLQILRMNNQGLGHEGCRHLVEALQKGRKASGGQGLRLKVFSAGRNRLENYGAQLLSDVFSD-MGSLEEVSLYQNGIGIHGIEGVNSLVKMMEKNAGLRILNLSDNTLTEKGGKAIAKALCSLPDLEELHLSDCLLRASGVAALARALEDPELVPNIRVLNLTGNEINRSIGISLILSL-GNKSKLQLLDLNANEFGTSGIQAIIRTL 331

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BLAST of Ran GTPase-activating protein 1 vs. TrEMBL
Match: A0A504YLS8 (Ran GTPase-activating protein 1 OS=Fasciola gigantica OX=46835 GN=FGIG_04561 PE=4 SV=1)

HSP 1 Score: 293.123 bits (749), Expect = 3.191e-84
Identity = 154/329 (46.81%), Postives = 221/329 (67.17%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSL--NLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            + ++GL  + +  +D+E +V+ L  N +      LSG+TLG+ AAE +   L + TK+Q+ +W+DLFTGRLKSEI+ AL  LS G+M +   LVELDLSDNAFGPNGV+GV +L+AS  C TL+ L MNNQGLGH+GCR LV+AL+K R  S  +G+ L+VF AGRNRLEN G  +L++  SD M SL+++ L QNGIGIHGI+GV++L+  ++ +  L++LN+SDNT+  +G K ++K L    DLEEL+LGDCL++ SG+  L + L    L  N++ ++++GNEI     I  I  + E K  ++ +DL  NE     +  I   L
Sbjct:    6 VDFSGLALKLDEPKDVEKIVEALVGNPDAFC-FNLSGSTLGIAAAEPIGIALEHNTKLQRCLWSDLFTGRLKSEIAPALRHLSTGVMASGACLVELDLSDNAFGPNGVIGVVDLIASPACATLQILRMNNQGLGHEGCRHLVEALQKGRKASGGRGLRLKVFSAGRNRLENYGARLLSDVLSD-MGSLEEVSLYQNGIGIHGIEGVNSLVKMMEKNAGLRILNLSDNTLTEKGGKAIAKALCSLPDLEELHLGDCLLRASGVAALARALEDPELVPNIRVLNLTGNEINRSVGISLILSL-ENKSKLQLLDLNANEFGTSGIQAIIRTL 331

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BLAST of Ran GTPase-activating protein 1 vs. TrEMBL
Match: A0A4S2MDX3 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000693 PE=4 SV=1)

HSP 1 Score: 292.352 bits (747), Expect = 4.897e-84
Identity = 159/338 (47.04%), Postives = 224/338 (66.27%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLN--QMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDAL 1114
            +++ GL  + +T ED+  +V +L  N   VT L L+GNTLG+ A+E L   L N  K+++ I++DLFTGRLK+EI+ AL  L  G++ +  HLVELDLSDNAFGPNGVVGV ELL+S  C+TL+ L MNNQGLGH+GCR L  AL+K R   N  G+ L+VF A RNRLEN G +ML +  +D M SL+++ L QNGIGIHG  G+ +L   L  +  L++LN+SDNT+  EG K ++K L   E LEEL+LGDC++++SG + L  VL+  +++ +L+ +++SGNEIT    +  +  +  +K  +ES+DL  NE  K  +  I   L   D L  L
Sbjct:   16 VTFAGLGLKLDTVEDVGFIVSELRSNTE-VTCLNLTGNTLGIVASEPLGAALENNKKLRRCIFSDLFTGRLKTEIAPALRHLCSGIISSGAHLVELDLSDNAFGPNGVVGVVELLSSPACFTLEVLRMNNQGLGHEGCRYLTQALEKGREACNRNGLALKVFSASRNRLENVGAQMLAKVLAD-MGSLEELSLCQNGIGIHGKDGMQSLSKILMANTKLRLLNLSDNTLTAEGGKIIAKALRSLEKLEELHLGDCILRSSGAQALAAVLDDPKVAPDLRVLNLSGNEITRQAGVSLVLSL-GSKSNLESLDLNANEFGKSGIQAIIRSLESIDLLHTL 350

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Cavefish
Match: rangap1b (ran GTPase-activating protein 1-like [Source:NCBI gene;Acc:103043879])

HSP 1 Score: 185.267 bits (469), Expect = 4.997e-50
Identity = 122/340 (35.88%), Postives = 194/340 (57.06%), Query Frame = 2

Query:  101 EYLSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDAL 1114
            E LSY G   + + E+ +E +V+++++    +  L+L GNT+GV AA  + + L    +++   W+D+FTGRL+SEI  AL SL   L+ +   L ELDLSDNAFGP+GV G+  LL S  C+TLK L +NN G+G  G   L  AL +    S+  G  + L+VFIAGRNRLEN G   L   F   + SL+++ + QNGI   GI     L  +++++ NL+VLN++DNT    G   +++ L +   ++ +  GDCL++  G   +   L +    +K +++S  EIT   A   +++ ++ K  ++ +DL  N + +     +KE +   DK D L
Sbjct:   20 EELSYKGQGLKLDDEQSVEKIVREIDQ-FRGLRALRLEGNTIGVEAAHAIAKALETHNELECCHWSDMFTGRLRSEIPPALKSLGSALITSGARLTELDLSDNAFGPDGVKGIETLLKSPVCHTLKELRLNNCGMGIGGGIILASALTECYKQSSAMGSPLKLKVFIAGRNRLENDGATALARAFQ-MIGSLEEVHMPQNGINHPGITA---LATAMQHNPNLRVLNLNDNTFTKRGAVAMAQALKHLRSIQVVNFGDCLVRTEGAIAIAAALREGLTVIKELNLSFGEIT-EAAALVLARALKDKPDLKKLDLNGNCLGEYGCEALKEAMESVDKSDVL 353

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Cavefish
Match: rangap1a (RAN GTPase activating protein 1a [Source:ZFIN;Acc:ZDB-GENE-060929-492])

HSP 1 Score: 180.259 bits (456), Expect = 2.760e-48
Identity = 115/329 (34.95%), Postives = 186/329 (56.53%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LSY G   + +  +  E +VK + E    +  L+L GNT+GV AA+ + + L +++  Q   W+D+FTGRL         SL   LM A   L  LDLSDNAFGP+GV G+  LL S+ C+TL+ L +NN G+G  G + L  AL +    S+  G  ++L+VFIAGRNRLEN G   L + F   + +L++I + QNGI   G+  + N   +++ +  L+VLN++DNT   +G   +++ L     ++ +  GDCL+++ G   + + L +    LK +++S  EIT   A+  ++K VE K  +E +DL  N   +     +++++
Sbjct:   23 LSYKGQGLKLDNAQTAEEIVKAIRE-FQGLQALRLEGNTIGVEAAQAIAKALEDKSDFQCCYWSDMFTGRL--------FSLGAALMSAGARLKVLDLSDNAFGPDGVKGIENLLKSATCHTLQELRLNNCGMGIGGGKILAAALTECHKKSSKLGAPLSLKVFIAGRNRLENDGATALAQAFQL-IGTLEEIHMPQNGINHPGVTALAN---AVQQNPQLRVLNLNDNTFTKKGAIAMAQALKNLRSVQVINFGDCLVRSEGAVAIAEALKEGLPILKELNLSFGEITEEAALA-VAKAVEHKDQLEKLDLNGNCFGEDGCQNLRDLM 337

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Cavefish
Match: ENSAMXT00000050645.1 (NLR family CARD domain-containing protein 3-like [Source:NCBI gene;Acc:103035935])

HSP 1 Score: 58.5362 bits (140), Expect = 2.227e-8
Identity = 90/347 (25.94%), Postives = 147/347 (42.36%), Query Frame = 2

Query:  149 DIEHVVKDLNENVNC----VTTLQLSGNTLGVNAAEKLIEPLSN-QTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIG--------------------------IHGIQGVDNLILSLKN-HINLKVLNISDNTIKPEGVKRLSKIL---PYF---EDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEI 1075
            D E V   L E++      ++ L LSG   G +  +KL   L +   + +KL  N+     +  E   ALSS    L     HL+ELDL +N  G +GV+ + ELL ++ C  L+ L   +  +  +G   L  ALK     SN     +E+ + G N   + G+++LT+   +  + LK + LL++                             I G  G+  L   LK+ H  +++L +S++ I  EG   LS  L   P      DL E  LG     N G++ L   LN     L+   +    I        +S +      I  +DL++N++  + LN++
Sbjct:  764 DAEEVCASLTESLGTDPLLLSELDLSGKIQGDSEMKKLSHLLEDSHCRTKKLKLNN---SSVTEEGCAALSS---ALCLNPSHLIELDLGENKLGNSGVMKLCELLNNNFC-KLQRLGFADCCITEKGYAALASALK-----SNPSSTLMELDLRG-NDPGDEGVQLLTDLTKNENSKLKTLRLLKSPAAEKAHATLTKQLGANPLRLREMVLKGKIQGDSGLKQLSDLLKDSHCRIEILGLSNSNITEEGCAALSSSLCSNPSHLIGLDLCENKLG-----NLGVQQLCSFLNNTHCKLQQFRLKNCSIKEKGCADLVSALCSNPTHINVLDLSKNKVGDLGLNQL 1092

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Cavefish
Match: ENSAMXT00000035222.1 (ribonuclease inhibitor-like [Source:NCBI gene;Acc:103031476])

HSP 1 Score: 54.299 bits (129), Expect = 3.684e-7
Identity = 65/217 (29.95%), Postives = 103/217 (47.47%), Query Frame = 2

Query:  338 ALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGI----QGVDNLILSL-KNHINLKVLNISDNTIKPEGVKRLSKIL--PYFE--DLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNE 961
            A   L+  L  A  HL+E+DLS+N  G  GV  +   L S  C  L+ L+++   L    C  L   L     +S +    LE+   G N L ++G+++L     D    LK+       +G+ G     +G  +L L+L  NH  LK L+IS N  +  G+K LS IL  P+ +   L   Y G C IK    ++  ++    +   +T+S++GN+
Sbjct:  272 ACEPLASVLESANPHLIEMDLSNNYIGDKGVKLLCSGLRSPNC-KLQKLSLDWCSLTDSCCSDLASVL-----SSQFCLRELEL---GDNDLLDSGVKLLCVGLQDPKCKLKR-------LGLSGCCVTKEGCSSLGLALSSNHSQLKDLDISYNHPEEHGLKELSTILDNPHCKLMKLSTEYGGKCRIKPGLQKYACEITLDPNTAHRTLSLNGNK 472

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Cavefish
Match: ENSAMXT00000055168.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000774.1:21:36365:-1 gene:ENSAMXG00000031550.1 transcript:ENSAMXT00000055168.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 52.373 bits (124), Expect = 5.462e-7
Identity = 65/241 (26.97%), Postives = 114/241 (47.30%), Query Frame = 2

Query:  104 YLSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPL-SNQTKIQKL-IWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLS 820
            +    G    W+   ++  V+K +N ++     L LS N L     + L E L S+  K++KL +    FT    S++S  L S++  L        ELDLS+N    +GV  ++E L SS C  L+ L +         C  L   L+   +NS+ K ++L       N L + G++ L++        L+K+ L+          G+ +++ S+ +  +LK L++S+N ++  GVK+LS
Sbjct:   20 FCRLVGCNFTWSVCNELASVLKSVNSSLK---ELDLSENELWDGGVKLLSEGLKSSHCKLEKLRLVGCNFTSYSCSDVSSVLESVNSSLK-------ELDLSENELQDDGVKDLSEGLKSSHC-KLEKLRLVGCNFTGYSCSDLSSVLES--VNSSLKELDL-----SENELRDDGVKKLSKGLKSSHCKLEKLRLVGCNFTSFSCSGLSSVLESVNS--SLKELDLSENKLRDYGVKKLS 240

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Sea Lamprey
Match: rangap1a (RAN GTPase activating protein 1a [Source:ZFIN;Acc:ZDB-GENE-060929-492])

HSP 1 Score: 182.956 bits (463), Expect = 2.111e-49
Identity = 112/312 (35.90%), Postives = 182/312 (58.33%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDL 1036
            +S+ G   + NT ED   VV  + +    +  L L GNT+GV AA+ +   L+ +   Q+ +W+D+FTGRL++EI  AL++L   ++ +   LVELDLSDNAFGP+GV     LL S  C++L+TL +NN G+G  G + L +AL +    S  +G  + L VF+AGRNRLEN G   L + F   M SL+++ + QNGI   GI     L  +   +  L+VLN++DNT    G   +++ L   + +E +  GDCL+++ G + +   L     ++K ++++  EI    A++ +++ +ETK   +++DL
Sbjct:   73 VSFKGECLKLNTAEDAGVVVTAI-QKCEHMEALSLEGNTIGVEAAKAIATALAEKPHFQRALWSDMFTGRLRTEIPPALTALGNAMVTSGARLVELDLSDNAFGPDGVRACDTLLRSRACFSLRTLRLNNCGMGIGGGKILAEALSECHRASAAEGKPLALRVFVAGRNRLENEGASALAKAFM-AMGSLEEVHVPQNGINHAGITA---LAKAFAKNPELRVLNLNDNTFTERGALSMAEALKVLKKVEVINFGDCLVRSVGAKAIAVALKDGLPHIKELNLAFGEINMDAAMQ-VAEALETKSFFKTLDL 378

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Yeast
Match: RNA1 (GTPase activating protein (GAP) for Gsp1p; involved in nuclear transport [Source:SGD;Acc:S000004848])

HSP 1 Score: 109.768 bits (273), Expect = 3.406e-26
Identity = 97/296 (32.77%), Postives = 153/296 (51.69%), Query Frame = 2

Query:  110 SYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLI----WNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMN---LEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLI-LSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFED-LEELYLGDCLIKNSGLEHLTKVLNQMSL-NLKTVSVSGNEIT 967
            S +G   +  T +DI+  +++L     C T L LSGNT+G  A+E L + ++  T++++ +    + DL+T RL  E+  +L  L   L++   HL  ++LSDNAFG   +  + + +A +    +K L ++N G+G     ++  AL    +  N K  +   LE FI GRNRLEN     L          LK + L QNGI     +GV  LI   L+   NL++L++ DNT        L+K LP ++D L EL L DCL+K +G + + KV  ++   NL  +    NE+ 
Sbjct:   17 SISGKALKLTTSDDIKPYLEELAALKTC-TKLDLSGNTIGTEASEALAKCIAENTQVRESLVEVNFADLYTSRLVDEVVDSLKFLLPVLLKCP-HLEIVNLSDNAFGLRTIELLEDYIAHAV--NIKHLILSNNGMGPFAGERIGKAL--FHLAQNKKAASKPFLETFICGRNRLENGSAVYLALGLKSHSEGLKVVKLYQNGI---RPKGVATLIHYGLQYLKNLEILDLQDNTFTKHASLILAKALPTWKDSLFELNLNDCLLKTAGSDEVFKVFTEVKFPNLHVLKFEYNEMA 303

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Nematostella
Match: EDO31643 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXB3])

HSP 1 Score: 185.267 bits (469), Expect = 2.261e-52
Identity = 119/312 (38.14%), Postives = 185/312 (59.29%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDL 1036
            +S+ G   + N+ ED   + + + +N   +  L L GNT+GV AA+ + E LS + + ++ +W+D+FTGR+++EI  A+ +LS  ++ A   LVELDLSDNAFGP+GV    +LL S  CY+LK L  NN GLG  G + L  AL     +S   G  + LEVFI+GRNRLEN G + L E F   + +L ++ + QNGI   GI     L  S +++ NLK++N++DN    +G   ++K+LP   ++E +  GDCL+K++G   L +       NLK + +S +EI    A+  ++K V+ K   + +DL
Sbjct:   26 ISFKGESLKLNSAEDAAKICEAI-KNCKDMQALCLEGNTIGVEAAKAIAEALSKRPEFERALWSDMFTGRVRAEIPPAMEALSDAVISAGTRLVELDLSDNAFGPDGVKACVKLLTSPACYSLKILRFNNNGLGVGGGKLLSGALLDNHKSSTAAGTPLKLEVFISGRNRLENPGSKCLAEAFKT-IGTLVEVQMPQNGIQHEGITA---LAESFRSNPNLKIINLNDNIFTEKGATSMAKVLPTLNNVEVINFGDCLVKSAGAVALAEACCTSLPNLKELILSFDEIKKDAALT-VAKSVQNKADFKKLDL 331

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BLAST of Ran GTPase-activating protein 1 vs. Ensembl Nematostella
Match: EDO35050 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SML2])

HSP 1 Score: 55.0694 bits (131), Expect = 6.303e-8
Identity = 52/174 (29.89%), Postives = 84/174 (48.28%), Query Frame = 2

Query:  194 VTTLQLSGNTLGVNAAEKLIEPLSNQTKIQ--KLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFS-DGMTSLKKIVLLQNGIGI 706
            + +L    N L    +  L E L++ T ++   L WND+  G        A+++L+ GL R    + ELDLS N F   GV+ V   L  S   +L+TL+++N G+   G   +   L+  R        NL+V   GRN  +NAG+  + E    +  +SL+++    +GIG 
Sbjct:  134 LKSLIFHSNNLSDQGSRLLSEALASNTALETLDLSWNDIRPG--------AMATLAKGL-RLNHTIQELDLSWNTFQSRGVIAVQWFLTHST--SLQTLDISNCGIHLDGAEVIAKVLRANR--------NLQVLKLGRNPFQNAGVPCILEAVRLNARSSLRELTF--DGIGF 286

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Medaka
Match: rangap1b (ran GTPase-activating protein 1-like [Source:NCBI gene;Acc:101160693])

HSP 1 Score: 204.142 bits (518), Expect = 9.591e-57
Identity = 126/339 (37.17%), Postives = 199/339 (58.70%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDALV 1117
            LSY GL  + +  E +  +V+D+  + + +  L+L GNT+GV AA+ + + L N+  +Q+  W+D+FTGRL+SEI  AL SL   +M A   L ELDLSDNAFGP+GV G+ +LL S+ C++LK L +NN G+G  G + L +AL +    S+  G  + L VF+AGRNRLEN G   L + F   + SL+++ L QNGI  H   GV  L  +++ +  L+V+N++DNT    G   ++  L    +++ +  GDCL+++ G   L  VL +    L+ V++S  EIT   A   +++ V  K  +E +DL  N + +     +++++   DK D L 
Sbjct:   23 LSYKGLGLKLDDAESVAELVRDIRRSSD-LRALRLEGNTVGVEAAQTIAKALENKEMLQRCYWSDMFTGRLRSEIPTALMSLGGAIMGAGARLTELDLSDNAFGPDGVKGIEQLLKSASCHSLKELRLNNCGMGIGGGKILAEALTEGHRRSSALGAPLRLRVFMAGRNRLENEGASALAKAFKL-IGSLEEVHLPQNGIN-HA--GVTALAAAMRQNPELRVVNLNDNTFTRRGALAMAHALRPLRNVQVINFGDCLVRSEGAVALAAVLREGLPTLREVNLSFGEIT-EAAAMAVAQAVADKPSMEKVDLNGNCLGEDGCEALRDLMENADKGDLLA 355

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Medaka
Match: rangap1a (Ran GTPase activating protein 1 [Source:NCBI gene;Acc:101170844])

HSP 1 Score: 179.874 bits (455), Expect = 3.552e-48
Identity = 112/329 (34.04%), Postives = 197/329 (59.88%), Query Frame = 2

Query:  107 LSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKG--MNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEIL 1087
            LSY G  ++ +  + +E +VK++ ++   +  L+L GNT+GV AA+ + + L  + +++   W+D+FTGR++SEI  AL+SL   LM A   L  LDLSDNAFGP+GV G+ +LL S+ CYTL+ L +NN G+G  G + L  +L      S+ +   ++L+VF+AGRNRLEN G   L + F   + +L+++ + QNGI  H   GV  L  +++ +  L++LN++DNT   +G   +++ L +   ++ +  GDCL++ +G + + + + +    L  +++S  EIT   A   ++  V+ K  ++ +DL  N + +     +KE++
Sbjct:   23 LSYKGQGRKLDDAKSVEEIVKNI-QDFEGLEALRLEGNTVGVEAAQAIAKALETKNELKCCYWSDMFTGRVRSEIPPALNSLGDALMLAGARLTVLDLSDNAFGPDGVKGIEKLLKSTSCYTLQELRLNNCGMGIGGGKILAASLMHCHQKSSAEKTPLSLKVFVAGRNRLENDGAAALAQAFQL-IGTLEEVHMPQNGIN-H--PGVTALASAMQQNPQLRILNLNDNTFTEKGALAMAQALKHLHSIQVINFGDCLVRPAGAKAIAEAVTEGLPALMELNLSFGEIT-EEAALALAHAVKDKEQLQRLDLNGNCLGEDGCKALKEVM 345

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Medaka
Match: nlrc3 (NLR family CARD domain containing 3 [Source:NCBI gene;Acc:101165263])

HSP 1 Score: 51.2174 bits (121), Expect = 4.090e-6
Identity = 67/242 (27.69%), Postives = 115/242 (47.52%), Query Frame = 2

Query:  194 VTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEF--FSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVL 913
            +T L L  N +G   A+ L E L      Q L   +     ++ E + AL+ +    ++    LV L++  N  G +G   + + L  +   TL  L + +  LG +G   L +ALK   +N     + L+      N + N GM  LT+   F+ G+ +L    L +N IGI   +G  N+  +LK + +L+ L+++ N +  EGV+ +S  + + + L  L+L    IK++     TKVL
Sbjct:  764 LTYLNLRNNNIGSKGAKFLAEALKMN---QVLTSINFQNNSIEEEGAQALAEV----LQCNRKLVSLNVRKNKIGADGAKRIADALKMN--QTLTKLILCSNQLGDKGTVALAEALK---LNQTLLSLQLQ-----SNSISNRGMTALTKALRFNHGLVTLN---LRENSIGI---EGAKNMAQALKENNSLQNLDLTANLLHDEGVQAISAAIKFNQGLTSLHLQWNFIKSTA----TKVL 978

[Close]

Query:  194 VTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEF--FSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVL 913
            +T L L  N +G   A+ L E L      Q L   +     ++ E + AL+ +    ++    LV L++  N  G +G   + + L  +   TL  L + +  LG +G   L +ALK   +N     + L+      N + N GM  LT+   F+ G+ +L    L +N IGI   +G  N+  +LK + +L+ L+++ N +  EGV+ +S  + + + L  L+L    IK++     TKVL
Sbjct:  764 LTYLNLRNNNIGSKGAKFLAEALKMN---QVLTSINFQNNSIEEEGAQALAEV----LQCNRKLVSLNVRKNKIGADGAKRIADALKMN--QTLTKLILCSNQLGDKGTVALAEALK---LNQTLLSLQLQ-----SNSISNRGMTALTKALRFNHGLVTLN---LRENSIGI---EGAKNMAQALKENNSLQNLDLTANLLHDEGVQAISAAIKFNQGLTSLHLQWNFIKSTA----TKVL 978

[Close]

BLAST of Ran GTPase-activating protein 1 vs. Planmine SMEST
Match: SMESG000061064.1 (SMESG000061064.1)

HSP 1 Score: 1327.77 bits (3435), Expect = 0.000e+0
Identity = 701/705 (99.43%), Postives = 703/705 (99.72%), Query Frame = 2

Query:   95 MLEYLSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDALVEDEANXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKADEKEETKLQITPTVTQSALFPNKIDCCKPSLTNGTAQSNLFAQSNQINPLNTARNIFGSQSAKPFSFLDAAKPSAFPVTGSLFATSQKQQFTFTNSDSSKPSLFSATAQSNLFSQSPQTNFLKPVNIFGTTSAKPFSFIEASATPNALEKELIEYVISNLHSDSLMSIKEFNSTINQTLGKFSFDANIYKTAEDFPENAVRVGLMLCKNTSTCDAGVELISHLLLSKSAWNRATNAILVEMDCIKCEEKKFVPFSEDNPKMPVKVLTNVLERNSSLPNEVKTNLTVVLKNLSKKSNDATDELLKKLECCVDNLRI 2209
            MLEYLSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGH AIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDALVEDEANSDGELSEDESD+YEGSGDDDDSSKSSTGEEEYSDEYSENDSYKADEKEETKLQITPTVTQSALFPNKIDCCKPSLTNGTAQSNLFAQSNQINPLNTARNIFGSQS+KPFSFLDAAKPSAFPVTGSLFATSQKQQFTFTNSDSSKPSLFSATAQSNLFSQSPQTNFLKPVNIFGTTSAKPFSFIEASATPNALEKELIEYVISNLHSDSLMSIKEFNS INQTLGKFSFDANIYKTAEDFPENAVRVGLMLCKNTSTCDAGVELISHLLLSKSAWNRATNAILVEMDCIKCEEKKFVPFSEDNPKMPVKVLTNVLERNSSLPNEVKTNLTVVLKNLSKKSNDATDELLKKLECCVDNLRI
Sbjct:    1 MLEYLSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAEKLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVELDLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALKKARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQNGIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFEDLEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHSAIKFISKIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDALVEDEANSDGELSEDESDNYEGSGDDDDSSKSSTGEEEYSDEYSENDSYKADEKEETKLQITPTVTQSALFPNKIDCCKPSLTNGTAQSNLFAQSNQINPLNTARNIFGSQSSKPFSFLDAAKPSAFPVTGSLFATSQKQQFTFTNSDSSKPSLFSATAQSNLFSQSPQTNFLKPVNIFGTTSAKPFSFIEASATPNALEKELIEYVISNLHSDSLMSIKEFNSNINQTLGKFSFDANIYKTAEDFPENAVRVGLMLCKNTSTCDAGVELISHLLLSKSAWNRATNAILVEMDCIKCEEKKFVPFSEDNPKMPVKVLTNVLERNSSLPNEVKTNLTVVLKNLSKKSNDATDELLKKLECCVDNLRI 705

The following BLAST results are available for this feature:

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Human
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Celegans
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Fly
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Zebrafish
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Xenopus
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Mouse
BLAST of Ran GTPase-activating protein 1 vs. UniProt/SwissProt
BLAST of Ran GTPase-activating protein 1 vs. TrEMBL
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Cavefish
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Sea Lamprey
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Yeast
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Nematostella
BLAST of Ran GTPase-activating protein 1 vs. Ensembl Medaka
BLAST of Ran GTPase-activating protein 1 vs. Planmine SMEST

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RANGAP1	7.798e-53	36.47	Ran GTPase activating protein 1 [Source:HGNC Symbo...	[more]
RANGAP1	7.798e-53	36.47	Ran GTPase activating protein 1 [Source:HGNC Symbo...	[more]
RANGAP1	7.798e-53	36.47	Ran GTPase activating protein 1 [Source:HGNC Symbo...	[more]
RANGAP1	4.922e-29	29.51	Ran GTPase activating protein 1 [Source:HGNC Symbo...	[more]
RANGAP1	7.044e-26	47.27	Ran GTPase activating protein 1 [Source:HGNC Symbo...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ran-2	1.957e-47	38.83	Ran GTPase-activating protein 2 [Source:UniProtKB...	[more]
ran-2	1.961e-47	38.83	Ran GTPase-activating protein 2 [Source:UniProtKB...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
RanGAP	1.193e-57	43.57	gene:FBgn0003346 transcript:FBtr0334175	[more]
RanGAP	1.452e-57	43.57	gene:FBgn0003346 transcript:FBtr0081234	[more]
RanGAP	1.452e-57	43.57	gene:FBgn0003346 transcript:FBtr0334174	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rangap1a	3.406e-55	35.78	RAN GTPase activating protein 1a [Source:ZFIN;Acc:...	[more]
rangap1b	1.956e-53	37.28	Ran GTPase activating protein 1b [Source:ZFIN;Acc:...	[more]
rangap1b	2.129e-53	37.28	Ran GTPase activating protein 1b [Source:ZFIN;Acc:...	[more]
rangap1b	6.459e-44	42.73	Ran GTPase activating protein 1b [Source:ZFIN;Acc:...	[more]
si:ch211-156p11.1	1.675e-14	26.26	si:ch211-156p11.1 [Source:ZFIN;Acc:ZDB-GENE-070912...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tcf7l1	3.107e-53	36.78	transcription factor 7 like 1 [Source:Xenbase;Acc:...	[more]
tcf7l1	4.373e-53	36.78	transcription factor 7 like 1 [Source:Xenbase;Acc:...	[more]
tcf7l1	4.963e-53	36.78	transcription factor 7 like 1 [Source:Xenbase;Acc:...	[more]
tcf7l1	1.835e-51	37.50	transcription factor 7 like 1 [Source:Xenbase;Acc:...	[more]
tcf7l1	3.704e-24	34.20	transcription factor 7 like 1 [Source:Xenbase;Acc:...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Rangap1	3.363e-51	36.47	RAN GTPase activating protein 1 [Source:MGI Symbol...	[more]
Rangap1	3.363e-51	36.47	RAN GTPase activating protein 1 [Source:MGI Symbol...	[more]
Rangap1	3.363e-51	36.47	RAN GTPase activating protein 1 [Source:MGI Symbol...	[more]
Rangap1	1.233e-47	42.98	RAN GTPase activating protein 1 [Source:MGI Symbol...	[more]
Rangap1	4.066e-30	47.97	RAN GTPase activating protein 1 [Source:MGI Symbol...	[more]

BLAST of Ran GTPase-activating protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9VIW3\|RAGP1_DROME	1.455e-56	43.57	Ran GTPase-activating protein OS=Drosophila melano...	[more]
sp\|O13066\|RAGP1_XENLA	2.285e-55	37.99	Ran GTPase-activating protein 1 OS=Xenopus laevis ...	[more]
sp\|P46060\|RAGP1_HUMAN	3.745e-52	36.47	Ran GTPase-activating protein 1 OS=Homo sapiens OX...	[more]
sp\|P46061\|RAGP1_MOUSE	2.352e-50	36.47	Ran GTPase-activating protein 1 OS=Mus musculus OX...	[more]
sp\|P34342\|RGP2_CAEEL	2.495e-46	38.83	Ran GTPase-activating protein 2 OS=Caenorhabditis ...	[more]

BLAST of Ran GTPase-activating protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A183A5Z9	4.120e-85	49.03	Uncharacterized protein OS=Echinostoma caproni OX=...	[more]
A0A3P8G2K2	7.290e-85	48.71	Uncharacterized protein OS=Echinostoma caproni OX=...	[more]
A0A4E0RKC2	9.051e-85	47.11	Ran GTPase-activating protein 1 OS=Fasciola hepati...	[more]
A0A504YLS8	3.191e-84	46.81	Ran GTPase-activating protein 1 OS=Fasciola gigant...	[more]
A0A4S2MDX3	4.897e-84	47.04	Uncharacterized protein OS=Opisthorchis felineus O...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rangap1b	4.997e-50	35.88	ran GTPase-activating protein 1-like [Source:NCBI ...	[more]
rangap1a	2.760e-48	34.95	RAN GTPase activating protein 1a [Source:ZFIN;Acc:...	[more]
ENSAMXT00000050645.1	2.227e-8	25.94	NLR family CARD domain-containing protein 3-like [...	[more]
ENSAMXT00000035222.1	3.684e-7	29.95	ribonuclease inhibitor-like [Source:NCBI gene;Acc:...	[more]
ENSAMXT00000055168.1	5.462e-7	26.97	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
rangap1a	2.111e-49	35.90	RAN GTPase activating protein 1a [Source:ZFIN;Acc:...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
RNA1	3.406e-26	32.77	GTPase activating protein (GAP) for Gsp1p; involve...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO31643	2.261e-52	38.14	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35050	6.303e-8	29.89	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4


Match Name	E-value	Identity	Description
rangap1b	9.591e-57	37.17	ran GTPase-activating protein 1-like [Source:NCBI ...	[more]
rangap1a	3.552e-48	34.04	Ran GTPase activating protein 1 [Source:NCBI gene;...	[more]
nlrc3	4.090e-6	27.69	NLR family CARD domain containing 3 [Source:NCBI g...	[more]
nlrc3	4.090e-6	27.69	NLR family CARD domain containing 3 [Source:NCBI g...	[more]

BLAST of Ran GTPase-activating protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000061064.1	0.000e+0	99.43	SMESG000061064.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30015929 ID=SMED30015929|Name=Ran GTPase-activating protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=2215bp
TTCCGATCTGAAATATTTGTTTGTTTAATAGTTTTTTTTTAAAATAGTTA
TAGAGAAATTTGATATTTAATTTTTACTATTTTGTGATTTTTAAATGTTA
GAATACTTATCTTATACTGGATTGCAAAAGCAGTGGAATACGGAAGAGGA
TATAGAACACGTTGTTAAGGACTTAAATGAAAATGTAAATTGTGTCACCA
CTCTTCAACTTAGTGGAAATACTCTTGGAGTTAATGCAGCGGAAAAGTTA
ATTGAACCTTTATCTAATCAAACAAAAATACAAAAATTGATTTGGAATGA
TTTATTTACTGGTCGATTAAAATCAGAAATAAGTGTTGCTCTTTCTTCTC
TTTCTATTGGCTTAATGAGAGCACAAGTTCATTTAGTAGAATTAGATTTA
AGTGATAATGCATTCGGACCAAATGGTGTTGTTGGTGTTACAGAACTTCT
TGCAAGTTCTTGTTGCTATACTTTAAAAACTCTTAATATGAACAATCAAG
GTTTAGGTCATCAAGGCTGCAGACAACTTGTCGATGCACTTAAAAAAGCT
CGAATTAACAGTAACTACAAAGGAATGAATTTAGAAGTTTTCATAGCAGG
GAGAAATCGACTAGAAAACGCTGGAATGGAAATGTTGACTGAATTCTTTT
CGGATGGAATGACAAGTCTTAAAAAAATTGTTTTGTTACAAAATGGAATC
GGTATTCATGGTATCCAAGGCGTTGACAACCTAATTTTGTCTCTTAAAAA
TCACATAAATTTGAAGGTGCTCAATATCTCCGATAATACTATTAAACCAG
AAGGTGTTAAACGACTGTCGAAAATTCTACCATATTTTGAAGACTTAGAA
GAACTGTATTTGGGCGATTGTTTGATTAAAAACAGTGGCTTGGAACACCT
GACTAAGGTTCTTAATCAAATGAGTTTAAATTTGAAGACAGTCTCAGTGT
CTGGAAATGAAATTACTGGTCACTGTGCAATTAAATTTATTTCCAAAATT
GTGGAAACTAAACACATAATTGAGAGTATTGATTTGACGGAAAACGAAAT
TAAAAAGGTCGCTTTAAATGAAATTAAAGAAATTCTCGCTGAACATGATA
AATTGGATGCTCTGGTAGAAGATGAGGCAAACAGTGATGGCGAATTAAGT
GAAGATGAAAGTGATGATTATGAAGGCAGTGGAGATGATGATGATAGTTC
CAAAAGTTCTACTGGTGAGGAGGAATATAGCGATGAATATAGCGAAAATG
ATTCATATAAAGCTGATGAAAAAGAAGAAACCAAATTGCAAATTACTCCG
ACAGTCACACAGTCGGCTTTATTTCCAAATAAAATTGATTGCTGTAAGCC
GTCCTTGACTAATGGAACTGCCCAATCAAATCTATTTGCGCAATCCAATC
AAATAAATCCTCTAAATACTGCTAGGAATATTTTCGGATCTCAATCTGCA
AAGCCATTTTCATTTCTCGATGCTGCAAAACCATCGGCATTTCCCGTTAC
CGGTAGCCTATTTGCTACCTCACAGAAGCAACAGTTTACATTCACAAATA
GCGATTCTAGCAAGCCATCTCTCTTCAGTGCAACTGCCCAGTCGAATTTA
TTCAGTCAGTCTCCCCAAACCAACTTTTTAAAGCCCGTCAACATCTTTGG
AACGACCTCAGCAAAACCATTCTCATTTATAGAGGCGTCGGCCACTCCTA
ATGCCTTGGAGAAGGAGCTTATCGAATATGTGATATCAAATCTCCACTCG
GATTCATTGATGTCTATTAAAGAATTCAATTCTACTATTAATCAAACACT
TGGAAAATTTTCTTTTGATGCAAACATTTATAAAACTGCAGAAGATTTCC
CGGAAAATGCTGTTCGAGTCGGTTTGATGTTATGCAAGAATACCTCAACT
TGCGATGCCGGTGTGGAATTGATCAGTCACTTGTTGTTGTCTAAATCTGC
CTGGAATAGAGCGACAAATGCGATCCTTGTCGAAATGGATTGTATAAAGT
GCGAGGAGAAAAAATTTGTCCCATTCTCTGAGGATAATCCCAAAATGCCA
GTGAAAGTGTTGACAAATGTACTAGAAAGGAATTCTAGTTTACCCAATGA
AGTCAAAACCAATTTGACTGTCGTTCTGAAGAATTTATCCAAAAAGTCCA
ACGATGCTACAGATGAATTATTAAAGAAATTGGAATGTTGTGTTGACAAT
TTAAGAATTTGATGT

protein sequence of SMED30015929-orf-1

>SMED30015929-orf-1 ID=SMED30015929-orf-1|Name=SMED30015929-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=706bp
MLEYLSYTGLQKQWNTEEDIEHVVKDLNENVNCVTTLQLSGNTLGVNAAE
KLIEPLSNQTKIQKLIWNDLFTGRLKSEISVALSSLSIGLMRAQVHLVEL
DLSDNAFGPNGVVGVTELLASSCCYTLKTLNMNNQGLGHQGCRQLVDALK
KARINSNYKGMNLEVFIAGRNRLENAGMEMLTEFFSDGMTSLKKIVLLQN
GIGIHGIQGVDNLILSLKNHINLKVLNISDNTIKPEGVKRLSKILPYFED
LEELYLGDCLIKNSGLEHLTKVLNQMSLNLKTVSVSGNEITGHCAIKFIS
KIVETKHIIESIDLTENEIKKVALNEIKEILAEHDKLDALVEDEANSDGE
LSEDESDDYEGSGDDDDSSKSSTGEEEYSDEYSENDSYKADEKEETKLQI
TPTVTQSALFPNKIDCCKPSLTNGTAQSNLFAQSNQINPLNTARNIFGSQ
SAKPFSFLDAAKPSAFPVTGSLFATSQKQQFTFTNSDSSKPSLFSATAQS
NLFSQSPQTNFLKPVNIFGTTSAKPFSFIEASATPNALEKELIEYVISNL
HSDSLMSIKEFNSTINQTLGKFSFDANIYKTAEDFPENAVRVGLMLCKNT
STCDAGVELISHLLLSKSAWNRATNAILVEMDCIKCEEKKFVPFSEDNPK
MPVKVLTNVLERNSSLPNEVKTNLTVVLKNLSKKSNDATDELLKKLECCV
DNLRI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005856	cytoskeleton

Vocabulary: **biological process**
Term	Definition
GO:0007165	signal transduction
GO:0043547	positive regulation of GTPase activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000204	ovary
PLANA:0000208	testis
PLANA:0000429	neoblast
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR032675	LRR_dom_sf
IPR001611	Leu-rich_rpt

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0005096	GTPase activator activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	SMART	SM00368	LRR_RI_2	coord: 189..216 e-value: 31.0 score: 6.7 coord: 220..247 e-value: 0.65 score: 18.5 coord: 94..121 e-value: 0.22 score: 20.6 coord: 31..58 e-value: 110.0 score: 2.6 coord: 248..275 e-value: 1.5 score: 16.0 coord: 124..151 e-value: 2.7 score: 14.1
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 345..362
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 345..399
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 363..398
None	No IPR available	PANTHER	PTHR24113	FAMILY NOT NAMED	coord: 9..400
None	No IPR available	PANTHER	PTHR24113:SF5	RAN GTPASE-ACTIVATING PROTEIN	coord: 9..400
None	No IPR available	SUPERFAMILY	SSF52047	RNI-like	coord: 16..335
IPR001611	Leucine-rich repeat	PFAM	PF13516	LRR_6	coord: 96..113 e-value: 0.078 score: 13.1 coord: 221..242 e-value: 0.0035 score: 17.3
IPR032675	Leucine-rich repeat domain superfamily	GENE3D	G3DSA:3.80.10.10		coord: 5..348 e-value: 1.6E-63 score: 216.6