Death-domain associated protein

Overview
NameDeath-domain associated protein
Smed IDSMED30015859
Length (bp)1854
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Death-domain associated protein (SMED30015859) t-SNE clustered cells

Violin plots show distribution of expression levels for Death-domain associated protein (SMED30015859) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Death-domain associated protein (SMED30015859) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Death-domain associated protein (SMED30015859) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30015859

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30015859SMESG000081382.1 SmedASXL_009078SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30015859SMESG000081382.1 dd_Smed_v4_12059_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Death-domain associated protein vs. Ensembl Human
Match: DAXX (death domain associated protein [Source:HGNC Symbol;Acc:HGNC:2681])

HSP 1 Score: 110.538 bits (275), Expect = 1.030e-24
Identity = 65/242 (26.86%), Postives = 125/242 (51.65%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI--STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +S+++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  MA D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A +    E G+     + +  ++ HS+D+      S E P  +A+Q  
Sbjct:  111 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGC 352
[Close]
BLAST of Death-domain associated protein vs. Ensembl Human
Match: DAXX (death domain associated protein [Source:HGNC Symbol;Acc:HGNC:2681])

HSP 1 Score: 110.538 bits (275), Expect = 1.030e-24
Identity = 65/242 (26.86%), Postives = 125/242 (51.65%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI--STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +S+++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  MA D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A +    E G+     + +  ++ HS+D+      S E P  +A+Q  
Sbjct:  111 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGC 352
[Close]
BLAST of Death-domain associated protein vs. Ensembl Human
Match: DAXX (death domain associated protein [Source:HGNC Symbol;Acc:HGNC:2681])

HSP 1 Score: 110.538 bits (275), Expect = 1.030e-24
Identity = 65/242 (26.86%), Postives = 125/242 (51.65%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI--STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +S+++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  MA D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A +    E G+     + +  ++ HS+D+      S E P  +A+Q  
Sbjct:  111 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGC 352
[Close]
BLAST of Death-domain associated protein vs. Ensembl Human
Match: DAXX (death domain associated protein [Source:HGNC Symbol;Acc:HGNC:2681])

HSP 1 Score: 110.538 bits (275), Expect = 1.030e-24
Identity = 65/242 (26.86%), Postives = 125/242 (51.65%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI--STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +S+++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  MA D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A +    E G+     + +  ++ HS+D+      S E P  +A+Q  
Sbjct:  111 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGC 352
[Close]
BLAST of Death-domain associated protein vs. Ensembl Human
Match: DAXX (death domain associated protein [Source:HGNC Symbol;Acc:HGNC:2681])

HSP 1 Score: 110.538 bits (275), Expect = 1.350e-24
Identity = 65/242 (26.86%), Postives = 125/242 (51.65%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI--STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +S+++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  MA D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A +    E G+     + +  ++ HS+D+      S E P  +A+Q  
Sbjct:  186 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGC 427
[Close]
BLAST of Death-domain associated protein vs. Ensembl Fly
Match: Daxx (gene:FBgn0031820 transcript:FBtr0079260)

HSP 1 Score: 82.0333 bits (201), Expect = 8.633e-16
Identity = 52/168 (30.95%), Postives = 90/168 (53.57%), Query Frame = 1 
Query:  562 LQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK-FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKN 1062
            L A  ++I+  EE E+   DL++E+SS++ L++ K    ++++KI  L+  + S+ +Q  K  +F  S+YP  N  ++ FV R + FPD+HD+  I+   N +  L L+   +  +A D F ++G  L+  R N+  +    H T   K   DP   D +L   L +N
Sbjct: 1281 LHAITKRIKMLEEAEV---DLNDEDSSYLQLERFKKRACQIYEKICDLKGESKSVRRQLKKPIHFKDSDYPHFNNSLSAFVNRMQDFPDYHDVLQILEKCNKEKELGLAKYEMKRIAYDAFNKVGRMLQSRRKNDLYETV-THYTANGK---DPASSDPELLAKLKEN 1441
[Close]
BLAST of Death-domain associated protein vs. Ensembl Fly
Match: Daxx (gene:FBgn0031820 transcript:FBtr0344764)

HSP 1 Score: 82.0333 bits (201), Expect = 8.633e-16
Identity = 52/168 (30.95%), Postives = 90/168 (53.57%), Query Frame = 1 
Query:  562 LQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK-FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKN 1062
            L A  ++I+  EE E+   DL++E+SS++ L++ K    ++++KI  L+  + S+ +Q  K  +F  S+YP  N  ++ FV R + FPD+HD+  I+   N +  L L+   +  +A D F ++G  L+  R N+  +    H T   K   DP   D +L   L +N
Sbjct: 1281 LHAITKRIKMLEEAEV---DLNDEDSSYLQLERFKKRACQIYEKICDLKGESKSVRRQLKKPIHFKDSDYPHFNNSLSAFVNRMQDFPDYHDVLQILEKCNKEKELGLAKYEMKRIAYDAFNKVGRMLQSRRKNDLYETV-THYTANGK---DPASSDPELLAKLKEN 1441
[Close]
BLAST of Death-domain associated protein vs. Ensembl Zebrafish
Match: daxx (death-domain associated protein [Source:ZFIN;Acc:ZDB-GENE-010110-3])

HSP 1 Score: 110.538 bits (275), Expect = 7.569e-25
Identity = 62/201 (30.85%), Postives = 117/201 (58.21%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKKF----PDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHEN 1125
            + I  LE +L+   E+I + +E +L+LDDL+ E+SS++   KLK   +K+++K+ +L+  N+   +   +   ++G+ YPE+N+++ +F+   +     PD+ DI  IV   N + +L+LS ++  +++ + F + GN+L++ R  + V NFG+HLTD  K   DP + D  L + L  N      +L+ V+  +A   E+
Sbjct:  198 RQIAYLENLLKVYNEEIRRLQEGDLSLDDLEKEDSSYIQEHKLKRKMMKIYEKLCELKGCNTLTGRVIEQKIPYSGTRYPEINKKVERFINSSEALLNPPDYSDILKIVQRANERYNLQLSRKQQAQISQEAFRETGNKLQERRHLDMVYNFGSHLTDPYKPTLDPALMDPALHRKLRSNRDVAISSLEEVINKYANKQED 398
[Close]
BLAST of Death-domain associated protein vs. Ensembl Zebrafish
Match: daxx (death-domain associated protein [Source:ZFIN;Acc:ZDB-GENE-010110-3])

HSP 1 Score: 110.538 bits (275), Expect = 7.585e-25
Identity = 62/201 (30.85%), Postives = 117/201 (58.21%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKKF----PDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHEN 1125
            + I  LE +L+   E+I + +E +L+LDDL+ E+SS++   KLK   +K+++K+ +L+  N+   +   +   ++G+ YPE+N+++ +F+   +     PD+ DI  IV   N + +L+LS ++  +++ + F + GN+L++ R  + V NFG+HLTD  K   DP + D  L + L  N      +L+ V+  +A   E+
Sbjct:  198 RQIAYLENLLKVYNEEIRRLQEGDLSLDDLEKEDSSYIQEHKLKRKMMKIYEKLCELKGCNTLTGRVIEQKIPYSGTRYPEINKKVERFINSSEALLNPPDYSDILKIVQRANERYNLQLSRKQQAQISQEAFRETGNKLQERRHLDMVYNFGSHLTDPYKPTLDPALMDPALHRKLRSNRDVAISSLEEVINKYANKQED 398
[Close]
BLAST of Death-domain associated protein vs. Ensembl Xenopus
Match: DAXX (death-associated protein 6 [Source:NCBI gene;Acc:100038126])

HSP 1 Score: 124.02 bits (310), Expect = 8.269e-29
Identity = 66/199 (33.17%), Postives = 117/199 (58.79%), Query Frame = 1 
Query:  541 ITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK--FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHENGQ 1131
            I  LE +LQ    +I+K +E+EL+LD+L++E+SS++   +LK   + ++ K+ +L+   S   +   +   + G+ YPE+N  + KF+      FPD+ D+  ++   N K+SL L  +++  MA D F ++GN+L++ R  + V NFG HLTD  K   DP ++D  L + L +N      +LD+++K +A M + G+
Sbjct:  174 IRYLENLLQTFSREIQKLQEKELSLDELEDEDSSYIQESRLKRKLLCIFHKLCQLKGCPSLTGRVIEQKIKYCGTRYPEVNRRLQKFINETSDGFPDYGDVLRVIQKANEKHSLGLVRRQMEGMAQDAFRELGNRLQERRHLDLVYNFGCHLTDAYKPGFDPALQDPALTRRLRENRGVALSHLDDIIKKYAEMQDEGE 372
[Close]
BLAST of Death-domain associated protein vs. Ensembl Xenopus
Match: DAXX (death-associated protein 6 [Source:NCBI gene;Acc:100038126])

HSP 1 Score: 123.635 bits (309), Expect = 9.293e-29
Identity = 66/199 (33.17%), Postives = 117/199 (58.79%), Query Frame = 1 
Query:  541 ITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK--FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHENGQ 1131
            I  LE +LQ    +I+K +E+EL+LD+L++E+SS++   +LK   + ++ K+ +L+   S   +   +   + G+ YPE+N  + KF+      FPD+ D+  ++   N K+SL L  +++  MA D F ++GN+L++ R  + V NFG HLTD  K   DP ++D  L + L +N      +LD+++K +A M + G+
Sbjct:  174 IRYLENLLQTFSREIQKLQEKELSLDELEDEDSSYIQESRLKRKLLCIFHKLCQLKGCPSLTGRVIEQKIKYCGTRYPEVNRRLQKFINETSDGFPDYGDVLRVIQKANEKHSLGLVRRQMEGMAQDAFRELGNRLQERRHLDLVYNFGCHLTDAYKPGFDPALQDPALTRRLRENRGVALSHLDDIIKKYAEMQDEGE 372
[Close]
BLAST of Death-domain associated protein vs. Ensembl Mouse
Match: Daxx (Fas death domain-associated protein [Source:MGI Symbol;Acc:MGI:1197015])

HSP 1 Score: 109.768 bits (273), Expect = 1.678e-24
Identity = 65/242 (26.86%), Postives = 122/242 (50.41%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI--STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +SS++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  +A D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A M    E G+     + +  +    SD      +S E P  +A+Q  
Sbjct:  192 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSSYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGLDTFPDYGDVLRAVEKAATRHSLGLPRQQLQLLAQDAFRDVGVRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPTLARRLRENRTLAMNRLDEVISKYAMMQDKTEEGERQKRRARLLGTAPQPSDPPKASSESGEGPSGMASQEC 433
[Close]
BLAST of Death-domain associated protein vs. Ensembl Mouse
Match: Daxx (Fas death domain-associated protein [Source:MGI Symbol;Acc:MGI:1197015])

HSP 1 Score: 109.768 bits (273), Expect = 1.678e-24
Identity = 65/242 (26.86%), Postives = 122/242 (50.41%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI--STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +SS++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  +A D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A M    E G+     + +  +    SD      +S E P  +A+Q  
Sbjct:  192 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSSYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGLDTFPDYGDVLRAVEKAATRHSLGLPRQQLQLLAQDAFRDVGVRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPTLARRLRENRTLAMNRLDEVISKYAMMQDKTEEGERQKRRARLLGTAPQPSDPPKASSESGEGPSGMASQEC 433
[Close]
BLAST of Death-domain associated protein vs. UniProt/SwissProt
Match: sp|Q8VIB2|DAXX_RAT (Death domain-associated protein 6 OS=Rattus norvegicus OX=10116 GN=Daxx PE=1 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 3.685e-25
Identity = 69/239 (28.87%), Postives = 123/239 (51.46%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSD-ISTEHSSDSEVFIEKSFENPISVANQ 1230
            + I +LE +L     +I++ +E+EL L +LD+ +SS++   +LK   ++++ ++  L++ +S   K   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  +A D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A M    E G+     +  ++T  SSD       S E P  VA+Q
Sbjct:  184 RQIQRLEQLLALYVAEIQRLQEKELDLSELDDPDSSYLQEARLKRKLIRLFGRLCDLKDCSSLTGKVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAATRHSLGLPRQQLQLLAQDAFRDVGVRLQERRHLDLIYNFGCHLTDDYRPGVDPALTDPTLARRLRENRTLAMSRLDEVISKYAMMQDKSEEGERQKRRARLLATSQSSDLPKASSDSGEGPSGVASQ 422
[Close]
BLAST of Death-domain associated protein vs. UniProt/SwissProt
Match: sp|Q9UER7|DAXX_HUMAN (Death domain-associated protein 6 OS=Homo sapiens OX=9606 GN=DAXX PE=1 SV=2)

HSP 1 Score: 110.538 bits (275), Expect = 6.550e-24
Identity = 65/242 (26.86%), Postives = 125/242 (51.65%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI--STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +S+++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  MA D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A +    E G+     + +  ++ HS+D+      S E P  +A+Q  
Sbjct:  186 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGC 427
[Close]
BLAST of Death-domain associated protein vs. UniProt/SwissProt
Match: sp|Q5TJE1|DAXX_CANLF (Death domain-associated protein 6 OS=Canis lupus familiaris OX=9615 GN=DAXX PE=3 SV=1)

HSP 1 Score: 110.153 bits (274), Expect = 7.706e-24
Identity = 66/243 (27.16%), Postives = 124/243 (51.03%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI---STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +S+++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  MA D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A M    E G+     + +   ++ HS+D       S E P  +A+Q  
Sbjct:  185 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSTYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGIDPALSDPALARRLRENRSLAMSRLDEVISKYAMMQDKSEEGERQKRRARLPQATSSHSTDPLKASLDSGEGPSGMASQEC 427
[Close]
BLAST of Death-domain associated protein vs. UniProt/SwissProt
Match: sp|O35613|DAXX_MOUSE (Death domain-associated protein 6 OS=Mus musculus OX=10090 GN=Daxx PE=1 SV=1)

HSP 1 Score: 109.768 bits (273), Expect = 1.141e-23
Identity = 65/242 (26.86%), Postives = 122/242 (50.41%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH---ENGQTLDSGSDI--STEHSSDSEVFIEKSFENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +SS++   +LK   ++++ ++ +L++ +S   +   +   + G+ YPE+N  I + + +     FPD+ D+   V     ++SL L  Q++  +A D F  +G +L++ R  + + NFG HLTD  +   DP + D  L + L +N       LD V+  +A M    E G+     + +  +    SD      +S E P  +A+Q  
Sbjct:  192 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSSYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGLDTFPDYGDVLRAVEKAATRHSLGLPRQQLQLLAQDAFRDVGVRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPTLARRLRENRTLAMNRLDEVISKYAMMQDKTEEGERQKRRARLLGTAPQPSDPPQASSESGEGPSGMASQEC 433
[Close]
BLAST of Death-domain associated protein vs. UniProt/SwissProt
Match: sp|O18805|DAXX_CHLAE (Death domain-associated protein 6 OS=Chlorocebus aethiops OX=9534 GN=DAXX PE=2 SV=1)

HSP 1 Score: 105.531 bits (262), Expect = 2.969e-22
Identity = 65/242 (26.86%), Postives = 124/242 (51.24%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK---FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHENGQTLDSGSDISTEH--SSDSEVFIEKSF---ENPISVANQNI 1236
            + I +LE +L     +I + +E+EL L +LD+ +S+++   +LK   ++++ ++ +L++ +S   +   +   + G+ YP++N  I + + +     FPD+ D+   V     ++SL L  Q++  MA D F  +G +L++ R  + + NFG HLT+  +   DP +    L + L +N I   + LD V+  +A + + G+        +  H  SS S    E S    E PI +A+Q  
Sbjct:  186 RQIQRLEQLLALYVAEIRRLQERELDLSELDDPDSTYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIKQRIPYRGTRYPKVNRRIERLINKPGPDTFPDYGDVLRAVKKAAARHSLGLPRQQLQLMAQDAFRNVGIRLQEQRHLDLIYNFGCHLTNDYRPGVDPALSYPVLARRLRENRILALIRLDQVISFYAMLQDGGEEGKKKKRRARLHGPSSHSANPPEPSLDSGEGPIGMASQGC 427
[Close]
BLAST of Death-domain associated protein vs. TrEMBL
Match: A0A2T7NMX3 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_18335 PE=4 SV=1)

HSP 1 Score: 148.673 bits (374), Expect = 1.218e-33
Identity = 80/221 (36.20%), Postives = 134/221 (60.63%), Query Frame = 1 
Query:  526 KIEKYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKK-FPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMH-ENGQ---TLDSGSDISTEHSS 1173
            K  K++ +LE +L+  +++IE+  E EL+L DLD E+SS++L D+L+  +VKVWK++ ++     S  +   K+F + G+ YPE+N +I+KFV R+K FPD+HDI GIV   N + SLKL+  +VN ++ + F  +G  L+  R  +F+  F +  T + + + DP + DE L++ L++N   G   LD V+  ++ +  E G+    +  GSD    H S
Sbjct:  364 KQAKHVMRLERLLEQLRDKIEQIREAELSLHDLDAEDSSYILEDRLQKKFVKVWKRLCEVTGRMPSTGRPVEKVFKYEGTRYPEVNRKISKFVNRRKIFPDYHDICGIVKKVNARLSLKLNANQVNNISREAFLDVGEALQNRRHKDFISTFRSKQTLEFRSDQDPALFDEDLQRKLNENRRIGMSRLDEVVSKYSNLQFETGEEPKEVPDGSDADRSHKS 584
[Close]
BLAST of Death-domain associated protein vs. TrEMBL
Match: H2KVJ0 (Death domain-associated protein 6 OS=Clonorchis sinensis OX=79923 GN=CLF_112466 PE=4 SV=1)

HSP 1 Score: 140.198 bits (352), Expect = 4.375e-31
Identity = 76/220 (34.55%), Postives = 120/220 (54.55%), Query Frame = 1 
Query:  541 ITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFV-KRKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHENGQTL-----DSGSDISTEHSSDSE 1182
            + +LE +L    + I   EE+EL +D LD+ NSS++ LD LK  Y++VW ++   R       +   + F + G  YP +N  I   V  +KKFPD+ DI+ IV S N   +L+L++  V E+A ++F  +G+ LK+ R ++  Q+ G HLTD ++ E+DP   D  LR+ L  N   GEL L+ V   +  + +N  T      D GS   ++H S  +
Sbjct:  228 VERLEHLLSRLSKAIRALEEEELDMDALDSNNSSYLKLDGLKRRYLQVWHRLCDARRMARISGRIVRRRFTYTGCKYPSVNSRIEYLVNDKKKFPDYTDIRRIVSSVNRDENLELTSSAVTELAREVFIDVGHLLKRRRQDDLRQDLGCHLTDDLQEEDDPTYYDSALRRQLAHNKTVGELRLNAVFDKYVQL-QNATTPPLVNEDQGSVDGSDHKSSCK 446
[Close]
BLAST of Death-domain associated protein vs. TrEMBL
Match: A0A4E0R9N9 (Death domain-associated protein 6 OS=Fasciola hepatica OX=6192 GN=D915_005246 PE=4 SV=1)

HSP 1 Score: 138.272 bits (347), Expect = 1.538e-30
Identity = 78/237 (32.91%), Postives = 130/237 (54.85%), Query Frame = 1 
Query:  523 DKIEKYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFV-KRKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHENGQTLDS-----GSDISTEHSS-DSEVFIEKSFENP 1212
            D+    +++LE +L    + I K EE EL  D LD+E+S ++ LD LK  Y+ VW+++ + R+   S  +   + F + G  Y  +N  I   V  +K+FPD  DI+ IV   N +  L+L +  V+++A  +F  +G++LK+ R ++ + +FG +LTD ++ E+DP   D  LR+ L +N   GE  L++V   F  + ++  T         S I TE SS DSE   ++S  +P
Sbjct:  182 DRRRAVVSRLERLLAQITKSIRKLEEHELDFDSLDSEHSPYIQLDVLKRRYLDVWRRLCEARKVARSSGRILRRRFVYTGCKYSSVNRMIENLVNDKKRFPDLMDIRRIVSHVNKQEKLQLRSVSVSDLARHVFIDVGHKLKQRRQSDLLHDFGCYLTDDLREEDDPTFADPSLRRKLAENRHAGEAKLNSVFDKFVQLQQSNPTYSDRVKPEPSTIKTELSSFDSEPLTKQSKYDP 418
[Close]
BLAST of Death-domain associated protein vs. TrEMBL
Match: A0A1S8WRT8 (Daxx domain-containing protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=X801_07042 PE=4 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 9.444e-30
Identity = 67/193 (34.72%), Postives = 109/193 (56.48%), Query Frame = 1 
Query:  541 ITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFV-KRKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATM 1116
            + +LE +L    + I   EE+EL +D L++ NSS++ LD LK  Y++VW ++   R       +   + F + G  YP +N  I   V  R+KFPD+ DI+ IV S N   +L+L +  V+++A ++F  +G+ LK+ R ++  Q+ G HLTD ++ E+DP   D  LR+ L  N   GEL L+ V   +  +
Sbjct:  192 VERLEHLLSRLSKAIRALEEEELDMDALESSNSSYLKLDGLKRRYLQVWHRLCDARRMARISGRIVRRRFTYAGCKYPSVNSRIEYLVNDRRKFPDYTDIRRIVSSVNRDENLELGSSAVSDLAREVFIDVGHLLKRRRQDDLRQDLGCHLTDDLQEEDDPTYYDSTLRRQLAHNKTVGELRLNAVFDKYVQL 384
[Close]
BLAST of Death-domain associated protein vs. TrEMBL
Match: A0A4S2MFL7 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000396 PE=4 SV=1)

HSP 1 Score: 135.576 bits (340), Expect = 1.094e-29
Identity = 68/193 (35.23%), Postives = 108/193 (55.96%), Query Frame = 1 
Query:  541 ITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFV-KRKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATM 1116
            + +LE +L    + I   EE+EL +D LD+ NSS++ LD LK  Y++VW ++   R       +   + F + G  YP +N  I   V  +KKFPD+ DI+ IV S N   +L+L++  V E+A ++F  +G+ LK+ R ++  Q+ G HLTD ++ E+DP   D  LR+ L  N   GE  L+ V   +  +
Sbjct:  193 VERLEHLLSRLSKAIRGLEEEELDMDALDSSNSSYLKLDGLKRRYLQVWHRLCDARRMARISGRIVRRRFTYTGCKYPSVNSRIEYLVNDKKKFPDYTDIRRIVSSVNRDENLELASSSVTELAREVFIDVGHLLKRRRQDDLRQDLGCHLTDDLQEEDDPTYYDYTLRRQLAHNKTVGEFRLNAVFDKYVQL 385
[Close]
BLAST of Death-domain associated protein vs. Ensembl Cavefish
Match: daxx (death domain associated protein [Source:NCBI gene;Acc:103026117])

HSP 1 Score: 111.309 bits (277), Expect = 4.033e-25
Identity = 63/196 (32.14%), Postives = 115/196 (58.67%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKKF----PDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFA 1110
            + I  LE +L+   ++I++ +E+EL LDDL+ E+SS+V   KLK   +K++ K+ +L+   +   +   +   ++G+ YPELN++I +F+ + +     PD+ DI  +V   N + SL LS +++ ++A + F + GN+L++ R  + V NFG+HLTD  K   DP + +  L + L  N      +L+ V+  +A
Sbjct:  185 RQIAYLENLLKVYNDEIKRLQERELGLDDLEKEDSSYVQEHKLKRKMMKIYDKLCELKGCTTMTGRVIEQRITYSGTRYPELNKKIERFINKPESQQNPPDYGDILQVVKRANERYSLTLSRKQLLQIAQEAFRETGNRLQERRHLDMVYNFGSHLTDLYKPTTDPALSNPSLSQKLRSNREVALTSLEEVINKYA 380
[Close]
BLAST of Death-domain associated protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004788.1 (pep scaffold:Pmarinus_7.0:GL479768:26396:30755:-1 gene:ENSPMAG00000004354.1 transcript:ENSPMAT00000004788.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 88.9669 bits (219), Expect = 4.124e-20
Identity = 53/201 (26.37%), Postives = 106/201 (52.74%), Query Frame = 1 
Query:  595 EEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKKF-PDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFA-----TMHENGQTLDSGSDISTEHSSDS 1179
            +E+EL LD+L  ++SS++   +LK   + ++ ++ +L+   +   +   +      + +PE+N  + + + +  F PD  D+KG+V + N + +L LS + V+ +++D F +   +L++ R  + V NFG HLT+  K  +DP   D +L   L +N +    +L++V+  +A     T  ++ Q         + HS DS
Sbjct:    2 QERELDLDELGRDDSSYLQEHQLKRKIMSIFSRLCELKGCTNMTGRVIEQRLYIKCTRHPEVNRHVERLINKPGFFPDLQDVKGVVRATNQRYNLGLSPREVHNVSLDAFREACTKLQERRHLDLVYNFGCHLTEDFKPSSDPARYDGELEAKLRRNRVVALQHLEDVVNKYAELEIPTSEQDKQEPGRRDGRDSRHSRDS 202
[Close]
BLAST of Death-domain associated protein vs. Ensembl Nematostella
Match: EDO43420 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYU1])

HSP 1 Score: 98.2117 bits (243), Expect = 1.078e-23
Identity = 56/179 (31.28%), Postives = 101/179 (56.42%), Query Frame = 1 
Query:  577 EQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVK-RKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFA 1110
            E+I++ +  EL+L+++++ +SS++   KL+    ++W KI  L+   ++  +   +      +  P+++  + +F+K R  FPD  DI+ +V +   K+ LK S    +E+A +IFT IGN+++K R  +F  NFG HLTD  K   DP + D  L + L  N  +GE  L+ V + + 
Sbjct:    4 EEIKRLDLVELSLEEMEHGHSSYIKKSKLEEKCNEIWNKICFLQRRPTNTGRVVEREVKCKSTGVPQIDRAVKRFLKNRTTFPDIFDIRNLVSNAVKKHKLKFSASVQDELANEIFTDIGNKMQKKRKKDFAYNFGCHLTDSCKPSKDPALDDHILLQKLEDNKRRGESALNEVFRKYV 182
[Close]
BLAST of Death-domain associated protein vs. Ensembl Medaka
Match: daxx (death domain-associated protein 6 [Source:NCBI gene;Acc:101167464])

HSP 1 Score: 108.227 bits (269), Expect = 3.601e-24
Identity = 61/201 (30.35%), Postives = 113/201 (56.22%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVK----RKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHEN 1125
            K I  LE +L+   ++I + ++ EL+L+DL+ E+S ++   KLK   +K+++K+ +L+  N+   +   +   +  + YPE+N+ I +F+     +K  PD+ DI   V   N +++L LS   +N++A + F + G+ L++ R+N+   NFG+HLTD  K   DP + D  L++ L  N       L+ V+  +A   E+
Sbjct:  214 KQIAYLENLLKVYNDEIFRLQQTELSLNDLEAEDSIYIQEHKLKRKLMKIYEKLCELKGCNTLTGRAIEERIEYKSTRYPEINKRIQRFINSPEVQKNPPDYQDILQQVLRANERHNLCLSKSHLNQIAQEAFRETGDLLQRRRLNDMFYNFGSHLTDNYKPTADPALSDSSLQQKLRSNREVAMSRLEEVITKYAVKQED 414
[Close]
BLAST of Death-domain associated protein vs. Ensembl Medaka
Match: daxx (death domain-associated protein 6 [Source:NCBI gene;Acc:101167464])

HSP 1 Score: 108.227 bits (269), Expect = 3.608e-24
Identity = 61/201 (30.35%), Postives = 113/201 (56.22%), Query Frame = 1 
Query:  535 KYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVK----RKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHEN 1125
            K I  LE +L+   ++I + ++ EL+L+DL+ E+S ++   KLK   +K+++K+ +L+  N+   +   +   +  + YPE+N+ I +F+     +K  PD+ DI   V   N +++L LS   +N++A + F + G+ L++ R+N+   NFG+HLTD  K   DP + D  L++ L  N       L+ V+  +A   E+
Sbjct:  214 KQIAYLENLLKVYNDEIFRLQQTELSLNDLEAEDSIYIQEHKLKRKLMKIYEKLCELKGCNTLTGRAIEERIEYKSTRYPEINKRIQRFINSPEVQKNPPDYQDILQQVLRANERHNLCLSKSHLNQIAQEAFRETGDLLQRRRLNDMFYNFGSHLTDNYKPTADPALSDSSLQQKLRSNREVAMSRLEEVITKYAVKQED 414
[Close]
BLAST of Death-domain associated protein vs. Planmine SMEST
Match: SMESG000081382.1 (SMESG000081382.1)

HSP 1 Score: 821.617 bits (2121), Expect = 0.000e+0
Identity = 488/491 (99.39%), Postives = 490/491 (99.80%), Query Frame = 1 
Query:  319 SHIESKKRKIVQEIPQNLTNIELEPEIHATIEYNTNILESNKPINDNNNSIDTGLFXXXXXXXXXXXXDKIEKYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHENGQTLDSGSDISTEHSSDSEVFIEKSFENPISVANQNIEQIAVETDNVNSSEPQLLIMNSSEISLNEIPNNVLSLLPVAPEISFDNTNKQLIFDMNIQKSIEKPSEEYLKEISSTTFRFNVEQMKHGDKSQYYKETIILXXXXXXXXXXXXXXXXXXXXXXRFTYSSKLDDFILSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPAVLNQKVSETFKSDGKI 1791
            S +ESKKRKIVQEIPQNLTNIELEPEIHATIEYNTNILESNKPINDNNNSIDTGLFSSNEENSSNVNNDKIEKYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHENGQTLDSGSDISTEHSSDSEVFIEKSFENPISVANQNIEQIAVETDNVNSSEPQLLIMNSSEISLNEIPNNVLSL+PVAPEISFDNTNKQLIFDMNIQKSIEKPSEEYLKEISSTTFRFNVEQMKHGDKSQYYKETIILNSDDSNESNGSDSEDIDDDKNSRFTYSSKLDDFILSKPKQKKPEIKEILINLDDYEDDDDIILIDPPAVLNQKVSETFKSDGKI
Sbjct:   89 SVVESKKRKIVQEIPQNLTNIELEPEIHATIEYNTNILESNKPINDNNNSIDTGLFSSNEENSSNVNNDKIEKYITKLEFVLQATKEQIEKFEEQELTLDDLDNENSSFVLLDKLKSHYVKVWKKISKLRETNSSLHKQYLKLFNFNGSNYPELNEEINKFVKRKKFPDFHDIKGIVFSFNVKNSLKLSTQRVNEMAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVLHKNYIQGELNLDNVMKNFATMHENGQTLDSGSDISTEHSSDSEVFIEKSFENPISVANQNIEQIAVETDNVNSSEPQLLIMNSSEISLNEIPNNVLSLIPVAPEISFDNTNKQLIFDMNIQKSIEKPSEEYLKEISSTTFRFNVEQMKHGDKSQYYKETIILNSDDSNESNGSDSEDIDDDKNSRFTYSSKLDDFILSKPKQKKPEIKEILINLDDYEDDDDIILIDPPAVLNQKVSETFKSDGKI 579

HSP 2 Score: 179.104 bits (453), Expect = 1.239e-48
Identity = 88/88 (100.00%), Postives = 88/88 (100.00%), Query Frame = 2 
Query:   62 MADKIWNKFAKDIKILSPNIDNTVLNKLKSNFFDMPNDYISSRICSDAMADTLKNINENKLKVYIHLLEFKKSMKNTKKLKRQHSKVI 325
            MADKIWNKFAKDIKILSPNIDNTVLNKLKSNFFDMPNDYISSRICSDAMADTLKNINENKLKVYIHLLEFKKSMKNTKKLKRQHSKVI
Sbjct:    1 MADKIWNKFAKDIKILSPNIDNTVLNKLKSNFFDMPNDYISSRICSDAMADTLKNINENKLKVYIHLLEFKKSMKNTKKLKRQHSKVI 88
The following BLAST results are available for this feature:
BLAST of Death-domain associated protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
DAXX1.030e-2426.86death domain associated protein [Source:HGNC Symbo... [more]
DAXX1.030e-2426.86death domain associated protein [Source:HGNC Symbo... [more]
DAXX1.030e-2426.86death domain associated protein [Source:HGNC Symbo... [more]
DAXX1.030e-2426.86death domain associated protein [Source:HGNC Symbo... [more]
DAXX1.350e-2426.86death domain associated protein [Source:HGNC Symbo... [more]
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BLAST of Death-domain associated protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Death-domain associated protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Daxx8.633e-1630.95gene:FBgn0031820 transcript:FBtr0079260[more]
Daxx8.633e-1630.95gene:FBgn0031820 transcript:FBtr0344764[more]
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BLAST of Death-domain associated protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
daxx7.569e-2530.85death-domain associated protein [Source:ZFIN;Acc:Z... [more]
daxx7.585e-2530.85death-domain associated protein [Source:ZFIN;Acc:Z... [more]
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BLAST of Death-domain associated protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
DAXX8.269e-2933.17death-associated protein 6 [Source:NCBI gene;Acc:1... [more]
DAXX9.293e-2933.17death-associated protein 6 [Source:NCBI gene;Acc:1... [more]
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BLAST of Death-domain associated protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Daxx1.678e-2426.86Fas death domain-associated protein [Source:MGI Sy... [more]
Daxx1.678e-2426.86Fas death domain-associated protein [Source:MGI Sy... [more]
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BLAST of Death-domain associated protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8VIB2|DAXX_RAT3.685e-2528.87Death domain-associated protein 6 OS=Rattus norveg... [more]
sp|Q9UER7|DAXX_HUMAN6.550e-2426.86Death domain-associated protein 6 OS=Homo sapiens ... [more]
sp|Q5TJE1|DAXX_CANLF7.706e-2427.16Death domain-associated protein 6 OS=Canis lupus f... [more]
sp|O35613|DAXX_MOUSE1.141e-2326.86Death domain-associated protein 6 OS=Mus musculus ... [more]
sp|O18805|DAXX_CHLAE2.969e-2226.86Death domain-associated protein 6 OS=Chlorocebus a... [more]
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BLAST of Death-domain associated protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2T7NMX31.218e-3336.20Uncharacterized protein OS=Pomacea canaliculata OX... [more]
H2KVJ04.375e-3134.55Death domain-associated protein 6 OS=Clonorchis si... [more]
A0A4E0R9N91.538e-3032.91Death domain-associated protein 6 OS=Fasciola hepa... [more]
A0A1S8WRT89.444e-3034.72Daxx domain-containing protein (Fragment) OS=Opist... [more]
A0A4S2MFL71.094e-2935.23Uncharacterized protein OS=Opisthorchis felineus O... [more]
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BLAST of Death-domain associated protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
daxx4.033e-2532.14death domain associated protein [Source:NCBI gene;... [more]
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BLAST of Death-domain associated protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000004788.14.124e-2026.37pep scaffold:Pmarinus_7.0:GL479768:26396:30755:-1 ... [more]
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BLAST of Death-domain associated protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Death-domain associated protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO434201.078e-2331.28Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Death-domain associated protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
daxx3.601e-2430.35death domain-associated protein 6 [Source:NCBI gen... [more]
daxx3.608e-2430.35death domain-associated protein 6 [Source:NCBI gen... [more]
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BLAST of Death-domain associated protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000081382.11.239e-4899.39SMESG000081382.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30015859 ID=SMED30015859|Name=Death-domain associated protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1854bp
TTTTAAATCAAGTTTTGAAATCAAAATTTTATTAAAAAATTTTATTTCAC
ATTTTCTTTTTATGGCAGACAAAATATGGAATAAATTCGCCAAAGATATA
AAAATCTTGAGTCCCAATATTGATAATACAGTTTTAAATAAGTTAAAGAG
TAACTTCTTCGATATGCCAAACGACTATATTTCTTCCAGAATATGCTCAG
ATGCAATGGCTGATACTTTGAAAAATATTAATGAAAACAAATTAAAAGTT
TACATACATTTACTGGAGTTTAAAAAATCGATGAAAAATACAAAGAAGCT
GAAACGACAACATTCAAAAGTCATATTGAAAGCAAGAAAAGAAAAATAGT
CCAAGAAATACCCCAAAATTTGACAAATATTGAGTTAGAGCCAGAAATTC
ATGCCACTATAGAGTACAATACAAATATATTGGAATCCAATAAACCAATA
AATGATAATAATAATTCAATTGATACTGGCTTATTCAGTTCGAATGAAGA
AAATTCCAGCAATGTTAATAATGATAAAATTGAAAAATATATCACCAAAT
TAGAATTTGTTTTACAGGCCACAAAAGAGCAAATTGAAAAGTTTGAGGAA
CAAGAATTGACTCTCGATGATTTGGATAATGAAAATAGTTCATTTGTACT
TTTGGACAAATTAAAATCGCATTATGTAAAAGTTTGGAAGAAAATATCTA
AATTGCGTGAGACCAATTCTAGTCTCCATAAACAATATTTAAAGTTATTT
AATTTCAACGGCTCAAATTATCCCGAGTTAAATGAAGAAATCAATAAATT
TGTAAAAAGGAAAAAGTTTCCCGATTTTCATGACATAAAAGGAATTGTGT
TTTCGTTCAACGTTAAAAATTCATTAAAACTAAGTACTCAAAGGGTCAAT
GAAATGGCTATTGATATTTTCACACAGATTGGAAATCAGTTGAAAAAGTT
AAGAATCAATGAATTTGTTCAAAACTTCGGGAATCATTTAACCGATCAAG
TGAAACATGAAAATGATCCTATCATACGCGATGAGCAATTGAGAAAAGTT
CTGCATAAAAACTATATCCAAGGAGAACTTAATTTAGATAATGTAATGAA
AAATTTTGCTACAATGCACGAAAATGGACAAACTTTAGATTCTGGTTCTG
ATATATCAACAGAACATTCATCAGATTCAGAAGTGTTTATAGAAAAATCA
TTTGAAAATCCCATTAGTGTGGCAAATCAAAATATTGAACAGATTGCAGT
AGAAACTGACAATGTTAATTCTTCAGAACCACAACTATTAATCATGAATT
CCTCAGAAATCTCACTAAATGAAATCCCCAATAACGTCTTATCTCTTTTA
CCTGTAGCTCCCGAAATTTCTTTTGATAATACTAACAAGCAGTTGATCTT
CGACATGAATATACAGAAATCCATCGAGAAACCGTCTGAAGAATATCTAA
AAGAAATTAGTTCAACAACTTTCCGATTTAATGTTGAACAAATGAAACAT
GGGGATAAAAGTCAATATTATAAGGAGACCATCATCCTCAACTCTGATGA
TAGCAATGAATCAAATGGGTCTGATTCTGAGGACATTGATGATGATAAGA
ACAGCCGTTTTACTTACAGTTCTAAATTAGACGATTTCATTTTGTCTAAG
CCGAAGCAAAAGAAACCGGAAATTAAAGAAATTTTAATCAATTTAGATGA
TTATGAGGATGATGACGATATTATTTTAATAGATCCACCAGCTGTATTAA
ATCAGAAAGTTAGCGAAACTTTCAAGTCCGACGGAAAAATATGAAAGATA
TTGCTGAATTATTGCTCAGGTCTTGAGTAACTGTTATACGATAAAATCCA
GTTT
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protein sequence of SMED30015859-orf-1

>SMED30015859-orf-1 ID=SMED30015859-orf-1|Name=SMED30015859-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=116bp
FKSSFEIKILLKNFISHFLFMADKIWNKFAKDIKILSPNIDNTVLNKLKS
NFFDMPNDYISSRICSDAMADTLKNINENKLKVYIHLLEFKKSMKNTKKL
KRQHSKVILKARKEK*
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protein sequence of SMED30015859-orf-2

>SMED30015859-orf-2 ID=SMED30015859-orf-2|Name=SMED30015859-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=297bp
MAIDIFTQIGNQLKKLRINEFVQNFGNHLTDQVKHENDPIIRDEQLRKVL
HKNYIQGELNLDNVMKNFATMHENGQTLDSGSDISTEHSSDSEVFIEKSF
ENPISVANQNIEQIAVETDNVNSSEPQLLIMNSSEISLNEIPNNVLSLLP
VAPEISFDNTNKQLIFDMNIQKSIEKPSEEYLKEISSTTFRFNVEQMKHG
DKSQYYKETIILNSDDSNESNGSDSEDIDDDKNSRFTYSSKLDDFILSKP
KQKKPEIKEILINLDDYEDDDDIILIDPPAVLNQKVSETFKSDGKI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003714transcription corepressor activity
GO:0019894kinesin binding
GO:0019901protein kinase binding
GO:0042803protein homodimerization activity
GO:0050681androgen receptor binding
GO:0003713transcription coactivator activity
GO:0005515protein binding
GO:0008134transcription factor binding
GO:0008432JUN kinase binding
Vocabulary: biological process
TermDefinition
GO:1903507negative regulation of nucleic acid-templated transcription
GO:0016569covalent chromatin modification
GO:0030578PML body organization
GO:0031396regulation of protein ubiquitination
GO:0033129positive regulation of histone phosphorylation
GO:0034605cellular response to heat
GO:0034620cellular response to unfolded protein
GO:0043065positive regulation of apoptotic process
GO:0045892negative regulation of transcription, DNA-templated
GO:0071276cellular response to cadmium ion
GO:0071280cellular response to copper ion
GO:0071356cellular response to tumor necrosis factor
GO:0071454cellular response to anoxia
GO:0072738cellular response to diamide
GO:1903936cellular response to sodium arsenite
GO:0000122negative regulation of transcription from RNA polymerase II promoter
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0006915apoptotic process
GO:0010038response to metal ion
GO:0010832negative regulation of myotube differentiation
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0002109X1 cell
Vocabulary: cellular component
TermDefinition
GO:0016605PML body
GO:0043005neuron projection
GO:0044297cell body
GO:0000775chromosome, centromeric region
GO:0001741XY body
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005694chromosome
GO:0005730nucleolus
GO:0005737cytoplasm
GO:0005829cytosol
GO:0005874microtubule
GO:0005938cell cortex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:1.20.58.2170coord: 1..77
e-value: 9.8E-16
score: 59.6
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 213..232