Dual specificity tyrosine-phosphorylation-regulated kinase 4
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30015820 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Human
Match: DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:HGNC Symbol;Acc:HGNC:3095]) HSP 1 Score: 409.838 bits (1052), Expect = 8.457e-136 Identity = 190/388 (48.97%), Postives = 277/388 (71.39%), Query Frame = 2
Query: 545 SLKVSPHNYQDHSP--HGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
S+K ++ SP + AL+ ++ QL+ EQ EI + ++WFLGL +KK + +DDE G Y+KV HDHIA+RYE+LET+GKGSFGQV K +DH+ VA+K+IRNKKRFHQQ+ +E+ IL+ L++K++ +++V+H+ + F+FRNH C+ FELLG NLY+++K NNF+GFSLS +++ + S+L CL +L E IIHCDLKPENI++ + +K+IDFGSSC+ ++K+YTYIQSRFYRSPEVILG PY ID+WS GC+ EL TG PLFPGE+E++QL CIMEV LPP ++ ++R++ FFD+KG P+++ N++G++R P+S+ + +K D+ F+D + CL W+ +R+ PD ALKH+W
Sbjct: 16 SIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKD--NTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLK-TYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Human
Match: DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:HGNC Symbol;Acc:HGNC:3095]) HSP 1 Score: 409.838 bits (1052), Expect = 8.457e-136 Identity = 190/388 (48.97%), Postives = 277/388 (71.39%), Query Frame = 2
Query: 545 SLKVSPHNYQDHSP--HGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
S+K ++ SP + AL+ ++ QL+ EQ EI + ++WFLGL +KK + +DDE G Y+KV HDHIA+RYE+LET+GKGSFGQV K +DH+ VA+K+IRNKKRFHQQ+ +E+ IL+ L++K++ +++V+H+ + F+FRNH C+ FELLG NLY+++K NNF+GFSLS +++ + S+L CL +L E IIHCDLKPENI++ + +K+IDFGSSC+ ++K+YTYIQSRFYRSPEVILG PY ID+WS GC+ EL TG PLFPGE+E++QL CIMEV LPP ++ ++R++ FFD+KG P+++ N++G++R P+S+ + +K D+ F+D + CL W+ +R+ PD ALKH+W
Sbjct: 16 SIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKD--NTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLK-TYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Human
Match: DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:HGNC Symbol;Acc:HGNC:3095]) HSP 1 Score: 410.994 bits (1055), Expect = 8.530e-135 Identity = 190/388 (48.97%), Postives = 277/388 (71.39%), Query Frame = 2
Query: 545 SLKVSPHNYQDHSP--HGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
S+K ++ SP + AL+ ++ QL+ EQ EI + ++WFLGL +KK + +DDE G Y+KV HDHIA+RYE+LET+GKGSFGQV K +DH+ VA+K+IRNKKRFHQQ+ +E+ IL+ L++K++ +++V+H+ + F+FRNH C+ FELLG NLY+++K NNF+GFSLS +++ + S+L CL +L E IIHCDLKPENI++ + +K+IDFGSSC+ ++K+YTYIQSRFYRSPEVILG PY ID+WS GC+ EL TG PLFPGE+E++QL CIMEV LPP ++ ++R++ FFD+KG P+++ N++G++R P+S+ + +K D+ F+D + CL W+ +R+ PD ALKH+W
Sbjct: 131 SIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKD--NTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLK-TYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWI 515
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 392.889 bits (1008), Expect = 4.021e-129 Identity = 188/386 (48.70%), Postives = 264/386 (68.39%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGRRRV----PNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P A++ Y +LT+ E EI + +I+FLGLN+KK + + G N GYDD+ G+Y++VPHDH+A+RYE+L+ +GKGSFGQV KA DH+ +VA+K++RN+KRFH+Q+ E+ IL+HL+++++ + +VIH+L +F FRNH C+ FELL NLY++IK+N F+GFSL ++K ++SIL CL L + IIHCDLKPENIL+ S IK+IDFGSSC+ ++++YTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL C++E+ +P + +L+ S R K F +KG PR L+ + RR P S+ + +K D F+D + CLEWD VR+ P AL+H W +
Sbjct: 80 PMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD--NTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 463
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Human
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:HGNC Symbol;Acc:HGNC:3093]) HSP 1 Score: 393.66 bits (1010), Expect = 1.830e-128 Identity = 188/386 (48.70%), Postives = 264/386 (68.39%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P A++ Y +LT+ E EI + +I+FLGLN+KK + + G N GYDD+ G+Y++VPHDH+A+RYE+L+ +GKGSFGQV KA DH+ +VA+K++RN+KRFH+Q+ E+ IL+HL+++++ + +VIH+L +F FRNH C+ FELL NLY++IK+N F+GFSL ++K ++SIL CL L + IIHCDLKPENIL+ S IK+IDFGSSC+ ++++YTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL C++E+ +P + +L+ S R K F +KG PR L+ + R R P S+ + +K D F+D + CLEWD VR+ P AL+H W +
Sbjct: 153 PMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD--NTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 536
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 373.244 bits (957), Expect = 1.137e-122 Identity = 181/383 (47.26%), Postives = 254/383 (66.32%), Query Frame = 2
Query: 605 PRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR---------------SLHNSKGRRRV-PNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
P A+Q + +L E+ EI ++ +++F+G ++KK + G + N GYDDE G+Y V HDHIA+RYE+L+ +GKGSFGQV KA DH+ VA+K++RN+KRFH+Q+ E+ IL HL+ ++ + ++IH+L+ F FRNH C+ FELL NLY++IKRN F+GFSL ++K +YS+L CL +L++ +IHCDLKPEN+L+ S IK+IDFGSSCF +++IYTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL I+E+ +PP LE + R + F +KG PR + +G+ R P S++ + +K D FVD + CL+WD R+ P ALKH W +
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSD--GTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLR 448
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 373.244 bits (957), Expect = 1.137e-122 Identity = 181/383 (47.26%), Postives = 254/383 (66.32%), Query Frame = 2
Query: 605 PRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR---------------SLHNSKGRRRV-PNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
P A+Q + +L E+ EI ++ +++F+G ++KK + G + N GYDDE G+Y V HDHIA+RYE+L+ +GKGSFGQV KA DH+ VA+K++RN+KRFH+Q+ E+ IL HL+ ++ + ++IH+L+ F FRNH C+ FELL NLY++IKRN F+GFSL ++K +YS+L CL +L++ +IHCDLKPEN+L+ S IK+IDFGSSCF +++IYTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL I+E+ +PP LE + R + F +KG PR + +G+ R P S++ + +K D FVD + CL+WD R+ P ALKH W +
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSD--GTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLR 448
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 373.244 bits (957), Expect = 1.137e-122 Identity = 181/383 (47.26%), Postives = 254/383 (66.32%), Query Frame = 2
Query: 605 PRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR---------------SLHNSKGRRRV-PNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
P A+Q + +L E+ EI ++ +++F+G ++KK + G + N GYDDE G+Y V HDHIA+RYE+L+ +GKGSFGQV KA DH+ VA+K++RN+KRFH+Q+ E+ IL HL+ ++ + ++IH+L+ F FRNH C+ FELL NLY++IKRN F+GFSL ++K +YS+L CL +L++ +IHCDLKPEN+L+ S IK+IDFGSSCF +++IYTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL I+E+ +PP LE + R + F +KG PR + +G+ R P S++ + +K D FVD + CL+WD R+ P ALKH W +
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSD--GTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLR 448
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 373.244 bits (957), Expect = 1.687e-122 Identity = 181/383 (47.26%), Postives = 254/383 (66.32%), Query Frame = 2
Query: 605 PRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR---------------SLHNSKGRRRV-PNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
P A+Q + +L E+ EI ++ +++F+G ++KK + G + N GYDDE G+Y V HDHIA+RYE+L+ +GKGSFGQV KA DH+ VA+K++RN+KRFH+Q+ E+ IL HL+ ++ + ++IH+L+ F FRNH C+ FELL NLY++IKRN F+GFSL ++K +YS+L CL +L++ +IHCDLKPEN+L+ S IK+IDFGSSCF +++IYTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL I+E+ +PP LE + R + F +KG PR + +G+ R P S++ + +K D FVD + CL+WD R+ P ALKH W +
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSD--GTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLR 448
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Celegans
Match: mbk-2 (Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9XTF3]) HSP 1 Score: 373.244 bits (957), Expect = 1.687e-122 Identity = 181/383 (47.26%), Postives = 254/383 (66.32%), Query Frame = 2
Query: 605 PRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR---------------SLHNSKGRRRV-PNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
P A+Q + +L E+ EI ++ +++F+G ++KK + G + N GYDDE G+Y V HDHIA+RYE+L+ +GKGSFGQV KA DH+ VA+K++RN+KRFH+Q+ E+ IL HL+ ++ + ++IH+L+ F FRNH C+ FELL NLY++IKRN F+GFSL ++K +YS+L CL +L++ +IHCDLKPEN+L+ S IK+IDFGSSCF +++IYTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL I+E+ +PP LE + R + F +KG PR + +G+ R P S++ + +K D FVD + CL+WD R+ P ALKH W +
Sbjct: 68 PEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSHAKKQAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSD--GTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWLR 448
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0100447) HSP 1 Score: 410.223 bits (1053), Expect = 1.225e-133 Identity = 196/373 (52.55%), Postives = 266/373 (71.31%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKT---EAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P ++ +R LT LE EE+ + ++W+ G ++ K A ++ N GYDD+ G Y + HDHIAFRYEILE +GKGSFGQV +A+DH+T +VA+K+IRNKKRF Q+ VE+NIL L+EK+ S +VIH+L+ +FR H C+ FEL+ NLY++IK+NN+ GFS+S I++ SI+ CL +L +ENIIHCDLKPENIL+ SS IK+IDFGSSC+ + KIYTYIQSRFYRSPEVILG+ Y T ID+WS GC+L EL TG PLFPGE+E++QL CIMEV LPPK ++ + R++LFFD++ PR + N+KGR+R P S+++ + D F+D + CLEWD R+ PD+A H + Q
Sbjct: 126 PMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADG--SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQ-DRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0089289) HSP 1 Score: 410.223 bits (1053), Expect = 1.225e-133 Identity = 196/373 (52.55%), Postives = 266/373 (71.31%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKT---EAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P ++ +R LT LE EE+ + ++W+ G ++ K A ++ N GYDD+ G Y + HDHIAFRYEILE +GKGSFGQV +A+DH+T +VA+K+IRNKKRF Q+ VE+NIL L+EK+ S +VIH+L+ +FR H C+ FEL+ NLY++IK+NN+ GFS+S I++ SI+ CL +L +ENIIHCDLKPENIL+ SS IK+IDFGSSC+ + KIYTYIQSRFYRSPEVILG+ Y T ID+WS GC+L EL TG PLFPGE+E++QL CIMEV LPPK ++ + R++LFFD++ PR + N+KGR+R P S+++ + D F+D + CLEWD R+ PD+A H + Q
Sbjct: 126 PMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADG--SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQ-DRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0100448) HSP 1 Score: 410.223 bits (1053), Expect = 1.225e-133 Identity = 196/373 (52.55%), Postives = 266/373 (71.31%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKT---EAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P ++ +R LT LE EE+ + ++W+ G ++ K A ++ N GYDD+ G Y + HDHIAFRYEILE +GKGSFGQV +A+DH+T +VA+K+IRNKKRF Q+ VE+NIL L+EK+ S +VIH+L+ +FR H C+ FEL+ NLY++IK+NN+ GFS+S I++ SI+ CL +L +ENIIHCDLKPENIL+ SS IK+IDFGSSC+ + KIYTYIQSRFYRSPEVILG+ Y T ID+WS GC+L EL TG PLFPGE+E++QL CIMEV LPPK ++ + R++LFFD++ PR + N+KGR+R P S+++ + D F+D + CLEWD R+ PD+A H + Q
Sbjct: 126 PMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADG--SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQ-DRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0089288) HSP 1 Score: 410.223 bits (1053), Expect = 1.225e-133 Identity = 196/373 (52.55%), Postives = 266/373 (71.31%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKT---EAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P ++ +R LT LE EE+ + ++W+ G ++ K A ++ N GYDD+ G Y + HDHIAFRYEILE +GKGSFGQV +A+DH+T +VA+K+IRNKKRF Q+ VE+NIL L+EK+ S +VIH+L+ +FR H C+ FEL+ NLY++IK+NN+ GFS+S I++ SI+ CL +L +ENIIHCDLKPENIL+ SS IK+IDFGSSC+ + KIYTYIQSRFYRSPEVILG+ Y T ID+WS GC+L EL TG PLFPGE+E++QL CIMEV LPPK ++ + R++LFFD++ PR + N+KGR+R P S+++ + D F+D + CLEWD R+ PD+A H + Q
Sbjct: 126 PMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADG--SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQ-DRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Fly
Match: Dyrk2 (gene:FBgn0016930 transcript:FBtr0089290) HSP 1 Score: 410.223 bits (1053), Expect = 1.225e-133 Identity = 196/373 (52.55%), Postives = 266/373 (71.31%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKT---EAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P ++ +R LT LE EE+ + ++W+ G ++ K A ++ N GYDD+ G Y + HDHIAFRYEILE +GKGSFGQV +A+DH+T +VA+K+IRNKKRF Q+ VE+NIL L+EK+ S +VIH+L+ +FR H C+ FEL+ NLY++IK+NN+ GFS+S I++ SI+ CL +L +ENIIHCDLKPENIL+ SS IK+IDFGSSC+ + KIYTYIQSRFYRSPEVILG+ Y T ID+WS GC+L EL TG PLFPGE+E++QL CIMEV LPPK ++ + R++LFFD++ PR + N+KGR+R P S+++ + D F+D + CLEWD R+ PD+A H + Q
Sbjct: 126 PMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADG--SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQ-DRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Zebrafish
Match: dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-091015-3]) HSP 1 Score: 449.514 bits (1155), Expect = 2.517e-150 Identity = 203/376 (53.99%), Postives = 281/376 (74.73%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHAN 1720
PM P +AL++++ QLT E+EEI +++IW+LGL++KK E +GS N GYDDE G+Y+KV HDHI +RYE+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFH Q+ VE+ IL ++ ++R +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL I++ ++S+L CL +L +E IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIME+ LPP ++ ++R++LFFD+KG PR++ NSKG++R P+S+ + S +K N D F+D I CL WD R+ PD+A++H W + N
Sbjct: 107 LPMSPTTALKHFQNQLTEYEREEIMDYSEIWYLGLDTKKIEGSQGSPQNAGYDDEHGSYLKVLHDHIGYRYEVLEVIGKGSFGQVLKCLDHKTNETVAIKIIRNKKRFHHQALVELKILDAVRRRDRD--NCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLGLIRRFAHSLLKCLQMLHKEKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEIMGLPPNDFVQTASRRRLFFDSKGNPRNITNSKGKKRRPSSKDLASVLKTN-DPLFLDFIQRCLVWDPTKRMTPDEAMQHEWITEGRLN 479
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Zebrafish
Match: dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-091015-3]) HSP 1 Score: 449.514 bits (1155), Expect = 3.334e-150 Identity = 203/376 (53.99%), Postives = 281/376 (74.73%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHAN 1720
PM P +AL++++ QLT E+EEI +++IW+LGL++KK E +GS N GYDDE G+Y+KV HDHI +RYE+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFH Q+ VE+ IL ++ ++R +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL I++ ++S+L CL +L +E IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIME+ LPP ++ ++R++LFFD+KG PR++ NSKG++R P+S+ + S +K N D F+D I CL WD R+ PD+A++H W + N
Sbjct: 117 LPMSPTTALKHFQNQLTEYEREEIMDYSEIWYLGLDTKKIEGSQGSPQNAGYDDEHGSYLKVLHDHIGYRYEVLEVIGKGSFGQVLKCLDHKTNETVAIKIIRNKKRFHHQALVELKILDAVRRRDRD--NCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLGLIRRFAHSLLKCLQMLHKEKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEIMGLPPNDFVQTASRRRLFFDSKGNPRNITNSKGKKRRPSSKDLASVLKTN-DPLFLDFIQRCLVWDPTKRMTPDEAMQHEWITEGRLN 489
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Zebrafish
Match: dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-091015-3]) HSP 1 Score: 449.899 bits (1156), Expect = 4.177e-150 Identity = 203/376 (53.99%), Postives = 281/376 (74.73%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHAN 1720
PM P +AL++++ QLT E+EEI +++IW+LGL++KK E +GS N GYDDE G+Y+KV HDHI +RYE+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFH Q+ VE+ IL ++ ++R +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL I++ ++S+L CL +L +E IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIME+ LPP ++ ++R++LFFD+KG PR++ NSKG++R P+S+ + S +K N D F+D I CL WD R+ PD+A++H W + N
Sbjct: 135 LPMSPTTALKHFQNQLTEYEREEIMDYSEIWYLGLDTKKIEGSQGSPQNAGYDDEHGSYLKVLHDHIGYRYEVLEVIGKGSFGQVLKCLDHKTNETVAIKIIRNKKRFHHQALVELKILDAVRRRDRD--NCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLGLIRRFAHSLLKCLQMLHKEKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEIMGLPPNDFVQTASRRRLFFDSKGNPRNITNSKGKKRRPSSKDLASVLKTN-DPLFLDFIQRCLVWDPTKRMTPDEAMQHEWITEGRLN 507
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Zebrafish
Match: dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-091015-3]) HSP 1 Score: 448.743 bits (1153), Expect = 4.725e-150 Identity = 203/376 (53.99%), Postives = 281/376 (74.73%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHAN 1720
PM P +AL++++ QLT E+EEI +++IW+LGL++KK E +GS N GYDDE G+Y+KV HDHI +RYE+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFH Q+ VE+ IL ++ ++R +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL I++ ++S+L CL +L +E IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIME+ LPP ++ ++R++LFFD+KG PR++ NSKG++R P+S+ + S +K N D F+D I CL WD R+ PD+A++H W + N
Sbjct: 114 LPMSPTTALKHFQNQLTEYEREEIMDYSEIWYLGLDTKKIEGSQGSPQNAGYDDEHGSYLKVLHDHIGYRYEVLEVIGKGSFGQVLKCLDHKTNETVAIKIIRNKKRFHHQALVELKILDAVRRRDRD--NCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLGLIRRFAHSLLKCLQMLHKEKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEIMGLPPNDFVQTASRRRLFFDSKGNPRNITNSKGKKRRPSSKDLASVLKTN-DPLFLDFIQRCLVWDPTKRMTPDEAMQHEWITEGRLN 486
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Zebrafish
Match: dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-091015-3]) HSP 1 Score: 448.743 bits (1153), Expect = 7.756e-150 Identity = 203/376 (53.99%), Postives = 281/376 (74.73%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHAN 1720
PM P +AL++++ QLT E+EEI +++IW+LGL++KK E +GS N GYDDE G+Y+KV HDHI +RYE+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFH Q+ VE+ IL ++ ++R +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL I++ ++S+L CL +L +E IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIME+ LPP ++ ++R++LFFD+KG PR++ NSKG++R P+S+ + S +K N D F+D I CL WD R+ PD+A++H W + N
Sbjct: 124 LPMSPTTALKHFQNQLTEYEREEIMDYSEIWYLGLDTKKIEGSQGSPQNAGYDDEHGSYLKVLHDHIGYRYEVLEVIGKGSFGQVLKCLDHKTNETVAIKIIRNKKRFHHQALVELKILDAVRRRDRD--NCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLGLIRRFAHSLLKCLQMLHKEKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEIMGLPPNDFVQTASRRRLFFDSKGNPRNITNSKGKKRRPSSKDLASVLKTN-DPLFLDFIQRCLVWDPTKRMTPDEAMQHEWITEGRLN 496
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 386.341 bits (991), Expect = 2.114e-126 Identity = 194/384 (50.52%), Postives = 264/384 (68.75%), Query Frame = 2
Query: 599 MGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
+ P A++ Y+ QL++ E +EIS F++I+F+G N+KK + + G N GYDD+ G Y VPHDH+A+RYE+L+ +GKGSFGQV K DH+ ++A+K++RN+KRFH+Q+ E+ IL+HLK++++ S +VIH+L SF FRNH C+ FELL NLY++IKRN F+GFSL ++K ++SIL CL L R IIHCDLKPENIL+ S IK+IDFGSSCF ++++YTYIQSRFYR+PEVILG Y ID+WSFGC+L ELLTG PLFPGE E DQL C+ME+ PP +LE++ R K F ++KG PR L+ S+ R R P S+ + +K DS F+D + CL WD R+ P AL+H W
Sbjct: 100 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKT--GSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWI 481
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 385.571 bits (989), Expect = 2.835e-126 Identity = 194/384 (50.52%), Postives = 264/384 (68.75%), Query Frame = 2
Query: 599 MGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
+ P A++ Y+ QL++ E +EIS F++I+F+G N+KK + + G N GYDD+ G Y VPHDH+A+RYE+L+ +GKGSFGQV K DH+ ++A+K++RN+KRFH+Q+ E+ IL+HLK++++ S +VIH+L SF FRNH C+ FELL NLY++IKRN F+GFSL ++K ++SIL CL L R IIHCDLKPENIL+ S IK+IDFGSSCF ++++YTYIQSRFYR+PEVILG Y ID+WSFGC+L ELLTG PLFPGE E DQL C+ME+ PP +LE++ R K F ++KG PR L+ S+ R R P S+ + +K DS F+D + CL WD R+ P AL+H W
Sbjct: 83 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKT--GSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWI 464
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 386.726 bits (992), Expect = 2.895e-126 Identity = 194/384 (50.52%), Postives = 264/384 (68.75%), Query Frame = 2
Query: 599 MGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
+ P A++ Y+ QL++ E +EIS F++I+F+G N+KK + + G N GYDD+ G Y VPHDH+A+RYE+L+ +GKGSFGQV K DH+ ++A+K++RN+KRFH+Q+ E+ IL+HLK++++ S +VIH+L SF FRNH C+ FELL NLY++IKRN F+GFSL ++K ++SIL CL L R IIHCDLKPENIL+ S IK+IDFGSSCF ++++YTYIQSRFYR+PEVILG Y ID+WSFGC+L ELLTG PLFPGE E DQL C+ME+ PP +LE++ R K F ++KG PR L+ S+ R R P S+ + +K DS F+D + CL WD R+ P AL+H W
Sbjct: 122 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKT--GSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWI 503
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Xenopus
Match: dyrk3 (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:NCBI gene;Acc:493520]) HSP 1 Score: 385.185 bits (988), Expect = 5.805e-126 Identity = 194/384 (50.52%), Postives = 264/384 (68.75%), Query Frame = 2
Query: 599 MGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
+ P A++ Y+ QL++ E +EIS F++I+F+G N+KK + + G N GYDD+ G Y VPHDH+A+RYE+L+ +GKGSFGQV K DH+ ++A+K++RN+KRFH+Q+ E+ IL+HLK++++ S +VIH+L SF FRNH C+ FELL NLY++IKRN F+GFSL ++K ++SIL CL L R IIHCDLKPENIL+ S IK+IDFGSSCF ++++YTYIQSRFYR+PEVILG Y ID+WSFGC+L ELLTG PLFPGE E DQL C+ME+ PP +LE++ R K F ++KG PR L+ S+ R R P S+ + +K DS F+D + CL WD R+ P AL+H W
Sbjct: 93 LTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKT--GSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWI 474
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Xenopus
Match: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2 [Source:NCBI gene;Acc:100485120]) HSP 1 Score: 385.571 bits (989), Expect = 5.140e-125 Identity = 186/385 (48.31%), Postives = 264/385 (68.57%), Query Frame = 2
Query: 599 MGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
+ P A++ Y +LT+ E EI ++ +I+FLG N+KK + + G N GYDD+ G+Y++VPHDH+A+RYE+L+ +GKGSFGQV KA DH+ +VA+K++RN+KRFH+Q+ E+ IL+HLK++++ + +VIH+L +F FRNH C+ FELL NLY++IK+N F+GFSL ++K ++SIL CL L + IIHCDLKPENIL+ S IK+IDFGSSC+ ++++YTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL C++E+ +P + +L+ S R K FF +KG PR L+ + R R P S+ + +K D F+D + CLEWD +R+ P AL+H W +
Sbjct: 178 LTPEQAMKQYMQKLTAFEHHEIFNYPEIYFLGPNAKKRQGVIGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKD--NNMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLR 560
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Mouse
Match: Dyrk4 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [Source:MGI Symbol;Acc:MGI:1330292]) HSP 1 Score: 407.912 bits (1047), Expect = 8.267e-134 Identity = 195/424 (45.99%), Postives = 291/424 (68.63%), Query Frame = 2
Query: 458 NQKPSWGSVNISQS---NCVDDSSRSTNQLDSSLKVSPHNYQDH----SPHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQD 1708
N+ PS G + ++ N V S T+++ ++ + + H H P+ AL+ ++ QL+ EQ EI ++++WFLGL +KK + +DDE G+Y+KV HDHIA+RYE+LE +GKGSFGQV K +DH+ VA+K+IRNKKRFH Q+ VE+ IL+ L+ K++ + +V+H+ + F+FRNH C+ FELLG NLY+++K N+F GF+LS +++ ++SIL CL +L E IIHCDLKPENI++ +K+IDFGSSC+ ++K+YTYIQSRFYRSPEVILG PY ID+WS GC++ EL TG PLFPGE+E++QL CIMEV LPP + ++R+++FFD+KG P++++N++G +R P+S+ + +K DS F+D + CL W+ +R+ P+ ALKH+W +
Sbjct: 97 NKVPSKGPMQYQENQIHNQVLSSELKTSEIPFNINTKAQDTKPHPELQKKHKVPLTVAEALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVVPEKFSKTSFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKD--NNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKNINNNRGGKRYPDSKDLTMVVK-TYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWIHE 517
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Mouse
Match: Dyrk3 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:MGI Symbol;Acc:MGI:1330300]) HSP 1 Score: 391.734 bits (1005), Expect = 4.820e-128 Identity = 196/426 (46.01%), Postives = 278/426 (65.26%), Query Frame = 2
Query: 485 NISQSNCVDDSSRST----NQLDSSLKVSPHNYQDHSPHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNS---------------KGRRR-VPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
N QS+ + +S +S+ + SL N P+ P AL+ Y+ LT+ E+ EI + +I+F+G N+KK + + G N GYDD GAYI VP DH+A+RYE+L+ +GKGSFGQV + DH+ VA+K++RN+KRFH+Q+ E+ IL+HLK++++ S +VIH+L SF FRNH C+ FELL +LY++IK+N F+GFS+ ++K + SIL L L + IIHCDLKPENIL+ ++ S K+IDFGSSCF +K+YTYIQSRFYR+PE+ILG Y+T IDIWSFGC+L ELLTG+PLFPGE E DQL C++E+ +PP+ +LE+S R K F ++KG PR S +G++R P S+ + +K D F++ + CL+WD R+ P AL+H W
Sbjct: 98 NTLQSDGISNSEKSSPASQGKSSESLSAVKCNLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT--GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWI 521
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Mouse
Match: Dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:MGI Symbol;Acc:MGI:1330301]) HSP 1 Score: 391.349 bits (1004), Expect = 9.292e-128 Identity = 187/386 (48.45%), Postives = 263/386 (68.13%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P A++ Y +LT+ E EI + +I+FLG N+KK + + G N GYDD+ G+Y++VPHDH+A+RYE+L+ +GKGSFGQV KA DH+ +VA+K++RN+KRFH+Q+ E+ IL+HL+++++ + +VIH+L +F FRNH C+ FELL NLY++IK+N F+GFSL ++K ++SIL CL L + IIHCDLKPENIL+ S IK+IDFGSSC+ ++++YTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL C++E+ +P + +L+ S R K F +KG PR L+ + R R P S+ + +K D F+D + CLEWD VR+ P AL+H W +
Sbjct: 151 PMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD--NTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 534
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 271.552 bits (693), Expect = 1.391e-81 Identity = 156/409 (38.14%), Postives = 233/409 (56.97%), Query Frame = 2
Query: 584 PHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSP------------NNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRE--NIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDN-KGEPRSLHNSKGRRR---VPNSQTIQSTMKMNADS-----------------KFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
P P+ R A +L+ + H N++++ +KK + + P N+GYDD+ YI + RYEI +GKGSFGQV KA DHQT VA+K+I+NKK F Q+ +E+ +L+ + + + + ++++HL F FRNH CLVFELL NLYD+++ +FRG SL+ +K++ + + L L +IIHCDLKPENIL+ N S IKI+DFGSSC ++IY YIQSRFYRSPEV+LG PY ID+WS GC+L E+ TG PLF G +E+DQ+ I+EV +PP +LE++ + + +F+ G +L +K R+ P ++ +Q + + +F DL+ LE++ RI P AL+H +F+
Sbjct: 30 PRRLPLAFRDAASAPLRKLSVDLIKTYKHINEVYY----AKKKRRAQQAPPQDSSTKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFR 432
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Mouse
Match: Dyrk1b (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b [Source:MGI Symbol;Acc:MGI:1330302]) HSP 1 Score: 268.855 bits (686), Expect = 6.459e-81 Identity = 153/389 (39.33%), Postives = 226/389 (58.10%), Query Frame = 2
Query: 584 PHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSP------------NNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRE--NIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQ-TIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
P P+ R A +L+ + H N++++ +KK + + P N+GYDD+ YI + RYEI +GKGSFGQV KA DHQT VA+K+I+NKK F Q+ +E+ +L+ + + + + ++++HL F FRNH CLVFELL NLYD+++ +FRG SL+ +K++ + + L L +IIHCDLKPENIL+ N S IKI+DFGSSC ++IY YIQSRFYRSPEV+LG PY ID+WS GC+L E+ TG PLF G +E+DQ+ I+EV +PP +LE++ + + +F+ R+P T++ T ++ DL+ LE++ RI P AL+H +F+
Sbjct: 30 PRRLPLAFRDAASAPLRKLSVDLIKTYKHINEVYY----AKKKRRAQQAPPQDSSTKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTE--MKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFE---------------RLPGGGWTLRRTKELRK-----DLVLRMLEYEPAARISPLGALQHGFFR 392
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. UniProt/SwissProt
Match: sp|Q9NR20|DYRK4_HUMAN (Dual specificity tyrosine-phosphorylation-regulated kinase 4 OS=Homo sapiens OX=9606 GN=DYRK4 PE=1 SV=2) HSP 1 Score: 409.838 bits (1052), Expect = 4.061e-135 Identity = 190/388 (48.97%), Postives = 277/388 (71.39%), Query Frame = 2
Query: 545 SLKVSPHNYQDHSP--HGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
S+K ++ SP + AL+ ++ QL+ EQ EI + ++WFLGL +KK + +DDE G Y+KV HDHIA+RYE+LET+GKGSFGQV K +DH+ VA+K+IRNKKRFHQQ+ +E+ IL+ L++K++ +++V+H+ + F+FRNH C+ FELLG NLY+++K NNF+GFSLS +++ + S+L CL +L E IIHCDLKPENI++ + +K+IDFGSSC+ ++K+YTYIQSRFYRSPEVILG PY ID+WS GC+ EL TG PLFPGE+E++QL CIMEV LPP ++ ++R++ FFD+KG P+++ N++G++R P+S+ + +K D+ F+D + CL W+ +R+ PD ALKH+W
Sbjct: 16 SIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKD--NTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLK-TYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. UniProt/SwissProt
Match: sp|Q8BI55|DYRK4_MOUSE (Dual specificity tyrosine-phosphorylation-regulated kinase 4 OS=Mus musculus OX=10090 GN=Dyrk4 PE=2 SV=1) HSP 1 Score: 407.912 bits (1047), Expect = 5.782e-133 Identity = 195/424 (45.99%), Postives = 291/424 (68.63%), Query Frame = 2
Query: 458 NQKPSWGSVNISQS---NCVDDSSRSTNQLDSSLKVSPHNYQDH----SPHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQD 1708
N+ PS G + ++ N V S T+++ ++ + + H H P+ AL+ ++ QL+ EQ EI ++++WFLGL +KK + +DDE G+Y+KV HDHIA+RYE+LE +GKGSFGQV K +DH+ VA+K+IRNKKRFH Q+ VE+ IL+ L+ K++ + +V+H+ + F+FRNH C+ FELLG NLY+++K N+F GF+LS +++ ++SIL CL +L E IIHCDLKPENI++ +K+IDFGSSC+ ++K+YTYIQSRFYRSPEVILG PY ID+WS GC++ EL TG PLFPGE+E++QL CIMEV LPP + ++R+++FFD+KG P++++N++G +R P+S+ + +K DS F+D + CL W+ +R+ P+ ALKH+W +
Sbjct: 97 NKVPSKGPMQYQENQIHNQVLSSELKTSEIPFNINTKAQDTKPHPELQKKHKVPLTVAEALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVVPEKFSKTSFDDEHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKD--NNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKNINNNRGGKRYPDSKDLTMVVK-TYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWIHE 517
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. UniProt/SwissProt
Match: sp|Q9V3D5|DYRK2_DROME (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Drosophila melanogaster OX=7227 GN=Dyrk2 PE=1 SV=1) HSP 1 Score: 410.223 bits (1053), Expect = 1.228e-132 Identity = 196/373 (52.55%), Postives = 266/373 (71.31%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKT---EAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P ++ +R LT LE EE+ + ++W+ G ++ K A ++ N GYDD+ G Y + HDHIAFRYEILE +GKGSFGQV +A+DH+T +VA+K+IRNKKRF Q+ VE+NIL L+EK+ S +VIH+L+ +FR H C+ FEL+ NLY++IK+NN+ GFS+S I++ SI+ CL +L +ENIIHCDLKPENIL+ SS IK+IDFGSSC+ + KIYTYIQSRFYRSPEVILG+ Y T ID+WS GC+L EL TG PLFPGE+E++QL CIMEV LPPK ++ + R++LFFD++ PR + N+KGR+R P S+++ + D F+D + CLEWD R+ PD+A H + Q
Sbjct: 126 PMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADG--SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQ-DRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. UniProt/SwissProt
Match: sp|Q92630|DYRK2_HUMAN (Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Homo sapiens OX=9606 GN=DYRK2 PE=1 SV=3) HSP 1 Score: 393.66 bits (1010), Expect = 8.787e-128 Identity = 188/386 (48.70%), Postives = 264/386 (68.39%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PM P A++ Y +LT+ E EI + +I+FLGLN+KK + + G N GYDD+ G+Y++VPHDH+A+RYE+L+ +GKGSFGQV KA DH+ +VA+K++RN+KRFH+Q+ E+ IL+HL+++++ + +VIH+L +F FRNH C+ FELL NLY++IK+N F+GFSL ++K ++SIL CL L + IIHCDLKPENIL+ S IK+IDFGSSC+ ++++YTYIQSRFYR+PEVILG Y ID+WS GC+L ELLTG PL PGE E DQL C++E+ +P + +L+ S R K F +KG PR L+ + R R P S+ + +K D F+D + CLEWD VR+ P AL+H W +
Sbjct: 153 PMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD--NTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 536
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. UniProt/SwissProt
Match: sp|Q922Y0|DYRK3_MOUSE (Dual specificity tyrosine-phosphorylation-regulated kinase 3 OS=Mus musculus OX=10090 GN=Dyrk3 PE=1 SV=1) HSP 1 Score: 391.734 bits (1005), Expect = 3.372e-127 Identity = 196/426 (46.01%), Postives = 278/426 (65.26%), Query Frame = 2
Query: 485 NISQSNCVDDSSRST----NQLDSSLKVSPHNYQDHSPHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNS---------------KGRRR-VPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
N QS+ + +S +S+ + SL N P+ P AL+ Y+ LT+ E+ EI + +I+F+G N+KK + + G N GYDD GAYI VP DH+A+RYE+L+ +GKGSFGQV + DH+ VA+K++RN+KRFH+Q+ E+ IL+HLK++++ S +VIH+L SF FRNH C+ FELL +LY++IK+N F+GFS+ ++K + SIL L L + IIHCDLKPENIL+ ++ S K+IDFGSSCF +K+YTYIQSRFYR+PE+ILG Y+T IDIWSFGC+L ELLTG+PLFPGE E DQL C++E+ +PP+ +LE+S R K F ++KG PR S +G++R P S+ + +K D F++ + CL+WD R+ P AL+H W
Sbjct: 98 NTLQSDGISNSEKSSPASQGKSSESLSAVKCNLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIVSYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT--GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVSTQTDGRVVLLGGRSRRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWI 521
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. TrEMBL
Match: A0A2B4SBZ4 (Dual specificity tyrosine-phosphorylation-regulated kinase 4 OS=Stylophora pistillata OX=50429 GN=DYRK4 PE=4 SV=1) HSP 1 Score: 479.559 bits (1233), Expect = 7.451e-159 Identity = 216/379 (56.99%), Postives = 297/379 (78.36%), Query Frame = 2
Query: 572 QDHSPHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQD 1708
+D + H PM P A++NY ++++ EQ EI F +WFLGL +KK E + G+ NNGYDDE+G+Y+K HDH+ +RYE+LE LGKGSFGQV KA+DH+TG +VAVK+IRNKKRFHQQ+ VEV IL+HL +K+++ ++++IH+++ F+FRNH C+ FEL+G NLY++IK+NNF+GFSL+ I++ +YS+L CL VL +E IIHCDLKPENIL+ S IK+IDFGSSC+ ++++YTYIQSRFYRSPEVILGIPY ID+WSFGC+L EL TG PLFPGE+E++QL CIME+ PP +VLE ++R+++FFD+KG PRS+ NSKG++R N + + + +K N D+ FVD I CLEWD R+ PD+A++H W Q+
Sbjct: 80 RDPNGHKLPMSPSVAIKNYGDKMSTFEQSEILDFPDVWFLGLEAKKIEGVPGAPQNNGYDDESGSYLKALHDHLVYRYEVLEVLGKGSFGQVVKALDHKTGQHVAVKIIRNKKRFHQQALVEVKILEHLLKKDKE--NNYNLIHMIDYFYFRNHLCISFELMGMNLYELIKKNNFQGFSLALIRRFAYSLLQCLRVLDKEKIIHCDLKPENILLRQRGQSSIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGIPYNMAIDMWSFGCILVELYTGYPLFPGENEVEQLACIMEILGKPPPNVLEPASRRRIFFDSKGNPRSMTNSKGKKRQVNGKELGAALKTN-DALFVDFIRGCLEWDPAARLTPDEAIQHEWIQE 455
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. TrEMBL
Match: A0A4E0QUJ3 (Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Fragment) OS=Fasciola hepatica OX=6192 GN=D915_010713 PE=3 SV=1) HSP 1 Score: 459.529 bits (1181), Expect = 5.131e-154 Identity = 211/383 (55.09%), Postives = 297/383 (77.55%), Query Frame = 2
Query: 581 SPHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHANDDC 1729
SP F +A+ Y LT+ E++E+ +++IWFLGL ++K I G+ N GYDDE G+Y+KV +DH+A+RYE+LETLGKGSFG+V +A DH+TG VAVK+IRNKKRFHQQ+ +EV +L+ LK+ + S H+IH+ + F FR+H C+VF+L+G+NLY+V+K+N+FRGF++ S++K++ +LSCL LR+ IIHCDLKPENIL+ NSS++ +IDFGSSC+ N+++YTYIQSRFYR+PE+ILG+PY T IDIWSFGC+LPEL TGRPLFPGE+E +QL CIMEV+ PP+++LE++ R+++FFD+KG PR+L NSKGR+R+P +T+Q +K ++D KF+DLI CL W+ RI P+ AL H WF++ + C
Sbjct: 11 SPIFFGSLYTAAVNRYGKNLTAFERQEVESYSEIWFLGLQAEKIHGIPGAPLNAGYDDEHGSYLKVTNDHLAYRYEVLETLGKGSFGRVVRAKDHRTGNFVAVKIIRNKKRFHQQAQIEVTVLEELKKVDSN--NSCHIIHIRDHFVFRDHLCIVFDLMGQNLYEVLKKNDFRGFTMHSLRKIATKLLSCLCALRKRGIIHCDLKPENILIGTKNSSDLCVIDFGSSCYTNKRVYTYIQSRFYRAPEIILGLPYGTPIDIWSFGCILPELFTGRPLFPGENENEQLACIMEVFGQPPENILEKANRRRIFFDSKGNPRNLVNSKGRKRLPGCRTLQELVK-SSDPKFLDLIQQCLRWNPDERITPEVALNHDWFREVTSQAKC 390
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. TrEMBL
Match: C3Y4L0 (Protein kinase domain-containing protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_211971 PE=3 SV=1) HSP 1 Score: 461.07 bits (1185), Expect = 7.441e-154 Identity = 209/365 (57.26%), Postives = 286/365 (78.36%), Query Frame = 2
Query: 614 ALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQD 1708
AL+ Y+ +LT EQ EI +N++WF+G ++K E I+GS NNGYDDE G+Y+KV HDH+A+RYE+LE +GKGSFGQV KAIDH+TG ++AVK+IRNKKRFH Q+ VEV IL L+ K+R + +VIH++ F+FRNH C+ FELLG NLY++IK+NNF+GFSL+ I++ ++++L C+ VL +E IIHCDLKPENIL+ + S IK+IDFGSSC+ +++YTYIQSRFYRSPEVILGIPY+ ID+WSFGC+L EL TG PLFPGE+E++QL CIMEV LPP +++++ R++LFFD++G+PR + NSKG++R PNS+ + ++ +D FVD I CLEWD +R P++A+KH W D
Sbjct: 21 ALKFYKGKLTGFEQSEILDYNEVWFVGAEARKIEGIQGSPQNNGYDDENGSYLKVIHDHLAYRYEVLEVIGKGSFGQVVKAIDHKTGEHIAVKIIRNKKRFHHQALVEVKILDALRRKDRD--GTMNVIHMVEYFYFRNHLCITFELLGMNLYELIKKNNFQGFSLALIRRFAHALLQCMKVLYKERIIHCDLKPENILLKSKGQSAIKVIDFGSSCYEFQRVYTYIQSRFYRSPEVILGIPYSMAIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEVLGLPPMRLIDDAQRRRLFFDSRGQPRCVTNSKGKKRRPNSKDLAQAIR-TSDPLFVDFIRRCLEWDPNLRWTPEEAMKHEWITD 382
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. TrEMBL
Match: A0A1E1XNC6 (Putative mitogen-activated protein kinase erk-a (Fragment) OS=Amblyomma sculptum OX=1581419 PE=2 SV=1) HSP 1 Score: 462.611 bits (1189), Expect = 8.351e-154 Identity = 221/395 (55.95%), Postives = 294/395 (74.43%), Query Frame = 2
Query: 584 PHG--FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFH-VIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHANDDCFKENQNSDIK 1759
PHG P+ P A+ Y +L++ E+ E+S + IW+LGL++ K E +G+ N GYDDETG+YIKV HDHIA+RYEILE +GKGSFGQV +A DH+T +VA+K+IRNKKRFHQQ+ +EV IL HLK+K++ ++H VIH+ + F+FRNH C+ FEL+G NLY++IK NN++GFSL+ I++ +YS++ CL +L RE IIHCDLKPENIL+ SS IK+IDFGSSCF ++++YTYIQSRFYRSPEVILG+PY T IDIWS GC+L EL TG PLFPGE E DQL CIMEV +PP +VLE +TR++LFFD+K PR NSKG++R PNS+T+ + + N D +FVD + CL W+ R+ PD+AL+HSW + +K Q +K
Sbjct: 9 PHGRRLPLSPAEAILYYGTRLSNYERSEVSQYRDIWYLGLDASKIEFDEGAGQNGGYDDETGSYIKVMHDHIAYRYEILEVIGKGSFGQVIRAYDHKTKEHVALKIIRNKKRFHQQALIEVKILDHLKKKDK---DAYHNVIHMYDYFYFRNHLCITFELMGMNLYELIKNNNYQGFSLNLIRRFAYSLVQCLRLLHREKIIHCDLKPENILLKQRGSSAIKVIDFGSSCFVHQRVYTYIQSRFYRSPEVILGLPYGTAIDIWSLGCILAELYTGFPLFPGEHEADQLACIMEVLGVPPVAVLELATRRRLFFDSKNVPRLTQNSKGKKRKPNSKTLAAVLGCN-DEEFVDFLSLCLVWNPETRVTPDEALRHSWLAMPKDSRQIYKTVQAITVK 399
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. TrEMBL
Match: A0A4Z2CUC2 (Dual specificity tyrosine-phosphorylation-regulated kinase 4 OS=Schistosoma japonicum OX=6182 GN=EWB00_007409 PE=4 SV=1) HSP 1 Score: 469.929 bits (1208), Expect = 1.054e-152 Identity = 214/377 (56.76%), Postives = 302/377 (80.11%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHAND 1723
PM PR+AL Y +LT+ E+EEI F++IW+LGL+++K + I+GSS N+GYDD+ G Y+K+ HDHIA+R++ LETLGKGSFG+V +AIDH++G VA+K+IRNKKRFHQQ+ VEV IL++LK+ + K + ++IH+ + F FRNH C+VF+LLG NLYD++++N+FRGF++ S++K++ +L+CL +LR++ IIHCDLKPENIL+ NNSSE+K+IDFGSSCF N+K YTYIQSRFYR+PE+ILGI Y ID+WS GC+LPEL TGRPLFPGE+E +QL CIMEV +P + +LE+++R+++FFD+K PR L NS+GR+R+P S+TI++ +K DSKF++L++ CL WD R+ P++AL H W H N+
Sbjct: 375 IPMTPRTALDMYSKKLTTFEREEILSFSKIWYLGLSAQKIDGIQGSSNNHGYDDDNGGYLKITHDHIAYRFQTLETLGKGSFGRVIRAIDHKSGFPVAIKIIRNKKRFHQQAQVEVAILENLKKADHK--NTHNIIHIRDHFTFRNHLCIVFDLLGSNLYDLLRKNDFRGFTIHSLKKITVKLLNCLCLLRKQGIIHCDLKPENILIGLNNSSELKVIDFGSSCFTNQKTYTYIQSRFYRAPEIILGISYGPPIDMWSLGCILPELYTGRPLFPGENENEQLACIMEVLGVPSELLLEKASRRRVFFDSKRTPRYLTNSRGRKRIPGSETIENLVKT-VDSKFINLLNQCLTWDPDERLTPNEALNHEWI--LHENE 746
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 459.529 bits (1181), Expect = 6.155e-154 Identity = 207/372 (55.65%), Postives = 284/372 (76.34%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQD 1708
PM P +AL++++ QLT EQEEI +++IW+LGL++KK E +GS N+GYDDE G+Y+KV HDHIA+RYE+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFHQQ+ VE+ IL ++ K+R + +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL+ I++ ++S+L CL +L RE IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIMEV +PP ++ ++R++LFFD+KG PR++ NSKG++R PNS+ + S +K N D F+D I CL WD R+ PD+ ++H W +
Sbjct: 129 LPMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIEGCQGSPQNSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRD--SCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNVTNSKGKKRRPNSKELASVLKTN-DPLFLDFIRRCLVWDPTKRMTPDEGMQHEWITE 497
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 459.529 bits (1181), Expect = 9.279e-154 Identity = 207/372 (55.65%), Postives = 284/372 (76.34%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQD 1708
PM P +AL++++ QLT EQEEI +++IW+LGL++KK E +GS N+GYDDE G+Y+KV HDHIA+RYE+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFHQQ+ VE+ IL ++ K+R + +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL+ I++ ++S+L CL +L RE IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIMEV +PP ++ ++R++LFFD+KG PR++ NSKG++R PNS+ + S +K N D F+D I CL WD R+ PD+ ++H W +
Sbjct: 137 LPMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIEGCQGSPQNSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRD--SCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNVTNSKGKKRRPNSKELASVLKTN-DPLFLDFIRRCLVWDPTKRMTPDEGMQHEWITE 505
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 458.373 bits (1178), Expect = 1.632e-153 Identity = 207/372 (55.65%), Postives = 284/372 (76.34%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQD 1708
PM P +AL++++ QLT EQEEI +++IW+LGL++KK E +GS N+GYDDE G+Y+KV HDHIA+RYE+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFHQQ+ VE+ IL ++ K+R + +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL+ I++ ++S+L CL +L RE IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIMEV +PP ++ ++R++LFFD+KG PR++ NSKG++R PNS+ + S +K N D F+D I CL WD R+ PD+ ++H W +
Sbjct: 126 LPMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIEGCQGSPQNSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRD--SCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNVTNSKGKKRRPNSKELASVLKTN-DPLFLDFIRRCLVWDPTKRMTPDEGMQHEWITE 494
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Cavefish
Match: dyrk4 (dual specificity tyrosine phosphorylation regulated kinase 4 [Source:NCBI gene;Acc:103029392]) HSP 1 Score: 459.144 bits (1180), Expect = 2.214e-153 Identity = 207/372 (55.65%), Postives = 284/372 (76.34%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQD 1708
PM P +AL++++ QLT EQEEI +++IW+LGL++KK E +GS N+GYDDE G+Y+KV HDHIA+RYE+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFHQQ+ VE+ IL ++ K+R + +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL+ I++ ++S+L CL +L RE IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIMEV +PP ++ ++R++LFFD+KG PR++ NSKG++R PNS+ + S +K N D F+D I CL WD R+ PD+ ++H W +
Sbjct: 154 LPMSPTAALKHFQSQLTEYEQEEIMDYSEIWYLGLDTKKIEGCQGSPQNSGYDDEHGSYLKVLHDHIAYRYEVLEVIGKGSFGQVLKCLDHKTNEMVAIKIIRNKKRFHQQALVELKILDAVRRKDRD--SCHNVIHMKEYFYFRNHLCISFELLGANLYELIKKNNFQGFSLALIRRFAHSLLKCLQMLHREKIIHCDLKPENILLSQRGQGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVMGMPPNDFVQTASRRRLFFDSKGNPRNVTNSKGKKRRPNSKELASVLKTN-DPLFLDFIRRCLVWDPTKRMTPDEGMQHEWITE 522
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Cavefish
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:103034036]) HSP 1 Score: 409.838 bits (1052), Expect = 2.893e-135 Identity = 197/387 (50.90%), Postives = 273/387 (70.54%), Query Frame = 2
Query: 590 GFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
G P+G AL+ YR QLT++EQ+E+ ++++I+F+G N+KK +A+ G S N GYDD+ G YI VPHDHIA+RYE L+ +GKGSFGQV K DH+ ++A+K++RN+KRFH+Q+ E+ IL+HLK++++ S +V+H+L +F FRNH C+ FELL NLY++IKRN F+GFSL ++K ++SIL CL L+R IIHCDLKPENIL+ S IK+IDFGSSCF ++++YTYIQSRFYR+PEVILG Y ID+WSFGC+L ELLTG PLFPGE E DQL C+ME+ +PP+ +LE++ R K F ++KG PR L+ S+ R R P S+ + +K D F+D + CL+W+ R+ P AL+H W
Sbjct: 125 GGPLGAEQALKQYRQQLTAMEQQEVHNYSEIFFVGPNAKKRQAVAGGSNNCGYDDDQGGYIHVPHDHIAYRYEFLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKT--GSMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALQRHKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMMELLGMPPQKLLEQAKRAKNFINSKGHPRYCTVTTLSNGTLVLNGSRSRRGKMRGPPGSKEWVTALKGCDDPTFIDFLRKCLDWEPSTRMTPVSALRHPWL 509
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 385.185 bits (988), Expect = 1.310e-126 Identity = 183/381 (48.03%), Postives = 260/381 (68.24%), Query Frame = 2
Query: 605 PRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSW 1699
P A++ Y +LT+ E +EI ++ +I+F+G N+KK + G + N GYDDE G+Y+ V HDH+A+RYE+L+ +GKGSFGQV KA DH+T +VA+K++RN+KRFH+Q+ E+ IL+HL++++R+ S ++IHLL SF FR H C+ FELL NLY++IK+N F+GFSL+ ++K ++SIL CL L R IIHCDLKPENIL+ S IK+IDFGSSCF ++++YTYIQSRFYR+PEV+LG Y ID+WS GC+L ELLTG PL PGE E DQL C ME+ +PP+ +L + R + F ++G PR L+ + R R P S+ + + ++ D +D + CLEW+ R+ P AL+H W
Sbjct: 96 PDQAVRLYGQKLTAYEHQEIYNYAEIYFVGHNAKKRPGVVGGASNCGYDDEQGSYVHVAHDHVAYRYEVLKVIGKGSFGQVVKAFDHKTQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDRE--NSMNIIHLLESFTFRGHVCMTFELLSMNLYELIKKNKFQGFSLALVRKFAHSILQCLDTLHRNRIIHCDLKPENILLKQPGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVVLGARYGPPIDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELLGMPPQRLLAQGKRSRNFVSSRGHPRYCGVTEAPDGAVVLNAGRSRRGKPRGPPGSRELPAALRGCDDPLLLDFLRGCLEWEPSERLTPAQALRHPW 474
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Sea Lamprey
Match: dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2804]) HSP 1 Score: 372.474 bits (955), Expect = 1.025e-121 Identity = 185/391 (47.31%), Postives = 255/391 (65.22%), Query Frame = 2
Query: 584 PHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIK-IIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
PH M P A++ Y +L+ E EI ++++++F+G ++KK +A NNG+DDE G+YI VPHDH+A+RYE+L +GKGSFGQV KA DH+T VA+K++RN+KRFH+Q+ E+ I K++ E + +VIH+L SF FRNH C+ FELL NLY++IK+N F+GFSL ++K ++SIL CL+ L + IIHCDLKPENIL+ S IK IIDFGSSC+ ++++YTYIQSRFYR+P G+P ID+WS GC+L ELLTG PL PGE E DQL C ME+ PP +LE+S R + FF + G PR L+ + R R P+S+ + +K D F+D + CL+WD R+ P ALKH W +
Sbjct: 99 PHSTAMSPEQAMRKYMHRLSMFEHHEIFNYHEVYFVGPSAKKRQATLSGVNNNGFDDEQGSYIHVPHDHVAYRYEVLRVIGKGSFGQVVKAYDHRTHQYVALKMVRNEKRFHRQAAEEIRI--LEHLKKQDKENTMNVIHMLESFNFRNHICMTFELLSMNLYELIKKNKFQGFSLQVVRKFAHSILLCLNALHKNRIIHCDLKPENILLRQQGRSGIKIIIDFGSSCYEHQRVYTYIQSRFYRAPGGRYGLP----IDMWSLGCILAELLTGSPLLPGEDEGDQLACAMELTGSPPARLLEQSKRARQFFSSLGHPRYCTVTTLPGGPVVLNGGRTRRGKLRGPPSSRDWTTALKGCDDHLFIDFLKKCLDWDPATRLTPSQALKHPWLR 483
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Sea Lamprey
Match: dyrk1aa (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a [Source:ZFIN;Acc:ZDB-GENE-050302-29]) HSP 1 Score: 264.618 bits (675), Expect = 2.068e-78 Identity = 148/331 (44.71%), Postives = 202/331 (61.03%), Query Frame = 2
Query: 800 RYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRE--NIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFF--------------DNKGE-----PRSLHN--------SKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
RYEI +GKGSFGQV KA DHQ VA+K+I+NKK F Q+ +EV +L+ + + + + ++++HL F FRNH CLVFELL NLYD+++ NFRG SL+ +K + + + L L +IIHCDLKPENIL+ N S IKI+DFGSSC ++IY YIQSRFYRSPEV+LGIPY ID+WS GC+L E+ TG PLF G +E+DQ+ I+EV LPP +LE++ + + +F D+K E R LH+ GRR T+ + KF DLI L++D + RI P AL+H++F+
Sbjct: 161 RYEIDSLIGKGSFGQVVKAYDHQEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTDM--KYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGLPPTHMLEQAPKARKYFERLSDGSWTVKKTKDSKREYKTAGSRKLHDIIGVESGGPGGRRMGEAGHTVADYL------KFKDLILRMLDYDPKTRITPFYALQHNFFK 483
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007952.1 (pep scaffold:Pmarinus_7.0:GL476685:157428:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007952.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 243.817 bits (621), Expect = 1.473e-75 Identity = 131/312 (41.99%), Postives = 192/312 (61.54%), Query Frame = 2
Query: 773 KVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFV-EVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
KV H+H+ +RYE+LE LG+GSFG+V K +DH++ VA+KV+ N+ RF++ E+ ILK L+ S +I ++ F FR C+VFELL NL +K + +GF L ++ + S+L L LR N+IH DLKP NI + + + E+K+ DFG SCF +E+ +T IQ+R YR+PEVIL + Y+ D+WS GC L EL +G+ LFPG + DQL IMEV+ LPP+ ++EES + FF K ++ ++G RVP S+ + ++ D F D I SCL+WD R+ P A+ H W +
Sbjct: 1 KVWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVL-NRARFNESVHRREIEILKRLQTAR----ESSKIIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEESRVQLGFFACKDFSSNVRLNRGLVRVPGSRALPLALR-TTDEHFTDFIRSCLQWDPEWRLTPHGAMDHEWVR 306
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007958.1 (pep scaffold:Pmarinus_7.0:GL476685:157443:173166:-1 gene:ENSPMAG00000007188.1 transcript:ENSPMAT00000007958.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 243.047 bits (619), Expect = 2.276e-75 Identity = 132/313 (42.17%), Postives = 192/313 (61.34%), Query Frame = 2
Query: 773 KVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFV-EVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFD-NKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
KV H+H+ +RYE+LE LG+GSFG+V K +DH++ VA+KV+ N+ RF++ E+ ILK L+ S +I ++ F FR C+VFELL NL +K + +GF L ++ + S+L L LR N+IH DLKP NI + + + E+K+ DFG SCF +E+ +T IQ+R YR+PEVIL + Y+ D+WS GC L EL +G+ LFPG + DQL IMEV+ LPP+ ++EES + FF K ++N +G RVP S+ + ++ D F D I SCL+WD R+ P A+ H W +
Sbjct: 1 KVWHEHLLYRYEVLEVLGQGSFGKVLKCLDHKSKEFVAIKVL-NRARFNESVHRREIEILKRLQTAR----ESSKIIRMMEHFSFRGRECVVFELLNGNLRSQLKLTHRQGFGLEMVRLFAISLLKSLEQLRDANVIHGDLKPGNIGICSYEAGEVKLFDFGCSCFDHEEHFTKIQTRHYRAPEVILDLGYSFPADMWSLGCTLAELHSGQKLFPGHTNEDQLHSIMEVFGLPPQDMIEESRVQLGFFAITKPTHWDINNHRGLVRVPGSRALPLALR-TTDEHFTDFIRSCLQWDPEWRLTPHGAMDHEWVR 307
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Yeast
Match: YAK1 (Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose [Source:SGD;Acc:S000003677]) HSP 1 Score: 226.868 bits (577), Expect = 1.063e-64 Identity = 115/254 (45.28%), Postives = 163/254 (64.17%), Query Frame = 2
Query: 737 NNGYDDETGAYIKVPHDHIAF----RYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLE 1486
NNG+D+ YI +D + +Y +L+ LG+G+FGQV K + T +AVKV++++ + QS E IL+ L +K H + + +SF +NH CLVFELL NLY+++K+N F G S+ I+ + IL L VL+ +IHCDLKPENIL+ + E+KIIDFGSSC +YTYIQSRFYR+PE+ILGIPY+T ID+WS GC++ EL G P+FPG SE +QL I++ PP +++
Sbjct: 343 NNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAKILELLNQKIDPT-NKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMID 595
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952]) HSP 1 Score: 139.428 bits (350), Expect = 2.573e-37 Identity = 90/315 (28.57%), Postives = 157/315 (49.84%), Query Frame = 2
Query: 800 RYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKR----NNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTY---IQSRFYRSPEVILGI-PYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDN--KGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFH 1714
+++ LE LG G++ V+K ++ TG+ VA+K ++ S I + K + + VIH N LVFE + +L + N RG L+ ++ + +L L+ I+H DLKP+N+L+ N ++K+ DFG + + + T+ + + +YR+P+V++G Y+T IDIWS GC+L E++TG+PLFPG ++ +QL I ++ P +S+ T+ + N + PR L Q +Q K D +D +H L+ + +R+ AL H WF +++
Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKL------TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLI--NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLR-----------QVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Yeast
Match: KNS1 (Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation [Source:SGD;Acc:S000003942]) HSP 1 Score: 139.813 bits (351), Expect = 5.064e-35 Identity = 90/291 (30.93%), Postives = 147/291 (50.52%), Query Frame = 2
Query: 752 DETGAYIKVPHDHIAF--RYEILETLGKGSFGQVFKAIDHQTGIN-VAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNN------------------------------SSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLP-PKSVLEESTRKKLFFDNK 1522
D+ G Y+ +D R+ + + LG+G+FG+V K ID++ N VAVKVIR R+ + + E+ IL+ + + + F + L F ++NH CLV +L G ++YD + N F S IQ ++ ++ + L IIH DLKPENIL+ + + EIKIIDFGS+ F+ E I +R YR+PE++LG+ ++ DIWS C+L EL+ G L+P ++ + + + P P +++ K+F+ +K
Sbjct: 294 DKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQG--QFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIID-----KMFYKSK 577
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Yeast
Match: KSS1 (Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]) HSP 1 Score: 133.65 bits (335), Expect = 1.325e-34 Identity = 105/337 (31.16%), Postives = 174/337 (51.63%), Query Frame = 2
Query: 791 IAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIR--NKKRFHQQSFVEVNIXXXXXXXXXXXXTSFH----VIHLLN-----SFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSS---IQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFG-SSCFYNEK---------IYTYIQSRFYRSPEVILGI-PYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHANDD 1726
I +Y++++ +G+G++G V AI +GI VA+K I+ +KK F ++ E+ +L++ FH +I +L+ S N LV EL+ +L VI N GFS S +Q +Y IL L + +IH D+KP N+L+ N++ ++K+ DFG + C + + Y+ +R+YR+PE++L YTT +DIWS GC+L E+++G+PLFPG QL I+EV P E+ + K +K + N R +P +T+ S +N D +DL+ L+++ RI +AL+H + +H D
Sbjct: 9 IPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRY-----------FHEHENIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQN-SGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLL--NSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPS---FEDFNQIK----SKRAKEYIANLPMRPPLP-WETVWSKTDLNPD--MIDLLDKMLQFNPDKRISAAEALRHPYLAMYHDPSD 321
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103]) HSP 1 Score: 123.635 bits (309), Expect = 9.298e-31 Identity = 91/312 (29.17%), Postives = 153/312 (49.04%), Query Frame = 2
Query: 791 IAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIR---NKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGI-PYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFH 1714
I RY L +G G+FG V A D T VA+K I + ++++ E+ +LKHL+ + + L + +F V EL G +L+ +++ R +Q Y IL L + +IH DLKP NIL+ N + ++KI DFG + + ++ Y+ +R+YR+PE++L Y ++DIWS GC+ E++ G+PLFPG+ + Q I ++ PPK V+ + + + + R +P S+ ++ + VDL+ L +D + RI DAL H + +H
Sbjct: 19 ITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYF-------VTELQGTDLHRLLQT---RPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILI--NENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTL-------KFVTSLPHRDPIPFSERFKT-----VEPDAVDLLEKMLVFDPKKRITAADALAHPYSAPYH 306
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Nematostella
Match: EDO36294 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJ45]) HSP 1 Score: 421.009 bits (1081), Expect = 1.568e-143 Identity = 190/338 (56.21%), Postives = 270/338 (79.88%), Query Frame = 2
Query: 635 QLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLE 1648
++T+ EQ EI + ++WFLGL++KK + + G+ NN YDD+ G+Y+K HDH+A+RYE+LE LGKGSFGQV KA+DH+TG +VAVK+IRNKKRFHQQ+ VEV IL +L++K++ + ++IH++ F+FRNH C+ FEL+G NLY++IK+NNF+GFSL+ I++ ++++L CL V+ +E IIHCDLKPENIL+ + IK+IDFGSSC+ ++++YTYIQSRFYRSPEVILG+PY+ ID+WSFGC+L EL TG PLFPGE+E++QL CIMEV LP ++E ++R++LFFD+KG PR + NSKG++R P+S+ I + +K N D+ F+D + CLE
Sbjct: 4 RITTFEQSEILDYPEVWFLGLDAKKIDGVPGAPQNNNYDDDNGSYLKALHDHLAYRYEVLEVLGKGSFGQVVKALDHKTGQHVAVKIIRNKKRFHQQALVEVKILDNLRKKDKD--NTHNLIHMIEHFYFRNHLCITFELMGMNLYELIKKNNFQGFSLALIRRFAFALLHCLKVIHKEKIIHCDLKPENILLRQRGQTSIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYSMAIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEVLGLPSPKLIESASRRRLFFDSKGIPRCITNSKGKKRRPSSRDISAALKTN-DALFLDFLKQCLE 338
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Nematostella
Match: EDO46144 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQP1]) HSP 1 Score: 391.734 bits (1005), Expect = 4.385e-129 Identity = 192/380 (50.53%), Postives = 262/380 (68.95%), Query Frame = 2
Query: 614 ALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR----------SLHNSKGRRR------VPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
A++ Y +L+ E EI +++QI+F+G +KK + + G + N GYDDE G+YI VP DHIA+RYE+L+ +GKGSFGQV KA+DH+T +VA+K++RN+KRFH+Q+ E+ IL+HLK++++ + ++IH+L F FRNH C+ FELL NLY++IK+N F+GFSL ++K ++SIL CL L + IIHCDLKPENIL+ S IK+IDFGSSC+ +++IYTYIQSRFYR+PEVILG Y ID+WSFGC+L ELLTG PLFPGE E DQL C ME+ P+ + E S R K F ++KG PR S+ S GR R PNS+T +K D+ F+D + CLEWD R+ P AL+H W +
Sbjct: 104 AMKQYMHKLSGYETHEIFNYSQIYFVGEAAKKRQGVVGGANNCGYDDEQGSYIHVPKDHIAYRYEVLKIIGKGSFGQVVKALDHKTNTHVALKMVRNEKRFHRQAQEEIRILEHLKKQDKD--NTHNIIHMLEHFTFRNHVCMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGARYGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACNMELLGYIPEKLRETSKRAKNFINSKGYPRYCTITTLPDGSVAVSGGRSRRGKTRGAPNSKTFVQALKGCDDAMFIDFLKRCLEWDPSARMTPSQALRHPWLR 481
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Nematostella
Match: EDO45187 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTC8]) HSP 1 Score: 271.937 bits (694), Expect = 2.654e-84 Identity = 158/382 (41.36%), Postives = 217/382 (56.81%), Query Frame = 2
Query: 668 HFNQIWFLGLNSKKTEAIKGSSP-------NNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRE--NIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGE-------------------PRSLHN--------SKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
H N++++ K E P N+GYDDE YI + RYEI +GKGSFGQV KA DHQ ++AVK+I+NKK F Q+ +EV +L+ + + + ++++ L F +RNH CLVFELL NLYD+++ NFRG SL+ +K + + + L L +IIHCDLKPENIL+ N S IKI+DFGSSC ++IY YIQSRFYRSPEV+LGIPY ID+WS GC+L E+ TG PLF G +E DQ++ I+EV +PPK +L+ + + + FFD + R LH+ GRR T+Q + KF DLI L++D + RI P AL H +F+
Sbjct: 27 HINEVYYANKKRPKPEEPDPVRPKKRPPQYNDGYDDENYDYIVKAGEKWFDRYEIESLIGKGSFGQVCKAYDHQEKEHIAVKIIKNKKPFLNQAQIEVKLLELMNKNDPD--GKYYIVRLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLCSPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQIGQRIYQYIQSRFYRSPEVLLGIPYNLAIDMWSLGCILVEMHTGEPLFSGANEFDQMMKIVEVLGMPPKDILDNAPKARKFFDRLPDGSYQCLKVKDGVKEYLSPGSRKLHDILGCETGGPGGRRLGEAGHTLQDYL------KFKDLILRMLDYDRKTRIVPYAALHHCFFK 400
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Nematostella
Match: EDO49238 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGV4]) HSP 1 Score: 187.963 bits (476), Expect = 7.348e-54 Identity = 113/339 (33.33%), Postives = 183/339 (53.98%), Query Frame = 2
Query: 809 ILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSS--EIKIIDFGSSCFYNEKIY-TYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRS------LHNSKGRRR---VPNSQ-------TIQSTMKMNADS---------------KFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHAND 1723
+LE LG+G+FGQV K T VA+K++++ + +Q +E++IL L + + +++ + + F +NH CLVFE+L +NLYD +K++ F L I+ + +L LS LR +IH DLKPENI++++ + +K+IDFGS+ ++ + TY+QSR+YR+PEVILG+P+ ID+WS GC++ EL G PL+PG SE DQ+ I++ LP +L +T+ FF + L N+ R +P+ + ++ ++N S +FV L+ L D RI P++AL H + H D
Sbjct: 1 VLEFLGRGTFGQVVKCWKKGTNELVAIKILKDHPSYARQGQIEISILAKLSAENSE---AYNFVRAIECFQHKNHTCLVFEMLQQNLYDYLKQSKFNPLPLKHIRPIVQQVLVALSKLRTLGLIHADLKPENIMLVDPDKQPFRVKVIDFGSATHVSKVVCSTYLQSRYYRAPEVILGLPFCESIDMWSLGCVIAELFLGWPLYPGSSEFDQIRYIIQTQGLPYDHLLNNATKTSRFFKKAINTHTGVLEWKLKNANEHERETKIPSKEARKYIFNSLDDIAQVNLSSSLTGNERIAEKIDRYEFVSLLKRMLTIDQEKRITPEEALSHQFVTLSHLVD 336
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Nematostella
Match: EDO33758 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SR83]) HSP 1 Score: 174.481 bits (441), Expect = 6.048e-48 Identity = 109/346 (31.50%), Postives = 186/346 (53.76%), Query Frame = 2
Query: 749 DDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNN-----------------SSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSK--FVDLIHSCLEWDARVRIQPDDALKHSWFQDFHANDDC 1729
DDE G I D + RYE+ LG+G+FG+V + D +TG VAVKVI+N +++ + + +E+ +L+ + +K R ++ I +L+ F H CLVFE +G +++D +K NN+ + L ++ +SY ++ + L + H DLKPEN+L +N++ SS +++IDFGS+ F +E T + +R YR+PEVIL + ++ DIWS GC++ EL TG LF + L + + P ++S + K F+ K E +S G+ N + ++ M +++ F +L+ LE+D RI +A++H +F + DC
Sbjct: 107 DDEDGHLIYHKGDQLHSRYEVHCLLGEGTFGKVLECYDKKTGDVVAVKVIKNIEKYREAAKLEIKVLEKINQKNRYGKSL--CIKMLDWFNHHGHMCLVFEKMGLSVFDFMKDNNYEPYPLDQVRHISYQLIVAVKFLHEMKLTHTDLKPENMLFVNSDCDVFYNKDTKQDQRYVKSSHMRLIDFGSATFEHEHHSTTVSTRHYRAPEVILELGWSYPCDIWSIGCIMFELYTGFTLFQTHENREHLAMMERIIGPIPSDFAKKSRKTKYFYKGKLEWDE-KSSSGKYVRENCKPLKKYMLSDSEGHQLFFNLLDYLLEYDPEKRITAKEAMQHPFFNSMYY--DC 447
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Medaka
Match: dyrk4 (dual specificity tyrosine-phosphorylation-regulated kinase 4 [Source:NCBI gene;Acc:101159741]) HSP 1 Score: 444.891 bits (1143), Expect = 2.135e-148 Identity = 201/370 (54.32%), Postives = 279/370 (75.41%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
PM P AL N++ +LT EQEEI+ + ++WFLGL S+K E +G+ N+GYDDE G+YI+V HDHIA+R+E+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFH Q+ VE+ IL+ +K+K++ +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL+ I++ ++++L CL +L +E IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIMEV +PP ++ ++R+KLFFD+KG PR++ NSKG++R PNS+ + + +K D F++ I CL WD R+ PD+ L+H W
Sbjct: 130 LPMSPSEALNNFQERLTEFEQEEINAYAEVWFLGLGSQKIEGSQGAPHNSGYDDEHGSYIRVLHDHIAYRFEVLEVIGKGSFGQVLKCLDHKTNELVAIKMIRNKKRFHHQALVELKILEVIKKKDKDNL--HNVIHMKEYFYFRNHLCISFELLGVNLYELIKKNNFQGFSLALIRRFAHALLRCLQMLHKEKIIHCDLKPENILLSQRGPGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELHTGYPLFPGESEVEQIACIMEVLGMPPNDFVQSASRRKLFFDSKGNPRNITNSKGKKRRPNSKELSAALK-TTDPLFLEFIKGCLTWDPTKRMTPDEGLQHQWI 496
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Medaka
Match: dyrk4 (dual specificity tyrosine-phosphorylation-regulated kinase 4 [Source:NCBI gene;Acc:101159741]) HSP 1 Score: 444.506 bits (1142), Expect = 4.349e-148 Identity = 201/370 (54.32%), Postives = 279/370 (75.41%), Query Frame = 2
Query: 593 FPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
PM P AL N++ +LT EQEEI+ + ++WFLGL S+K E +G+ N+GYDDE G+YI+V HDHIA+R+E+LE +GKGSFGQV K +DH+T VA+K+IRNKKRFH Q+ VE+ IL+ +K+K++ +VIH+ F+FRNH C+ FELLG NLY++IK+NNF+GFSL+ I++ ++++L CL +L +E IIHCDLKPENIL+ IK++DFGSSC+ +++YTYIQSRFYRSPEVILG PY+ ID+WS GC+L EL TG PLFPGESE++Q+ CIMEV +PP ++ ++R+KLFFD+KG PR++ NSKG++R PNS+ + + +K D F++ I CL WD R+ PD+ L+H W
Sbjct: 145 LPMSPSEALNNFQERLTEFEQEEINAYAEVWFLGLGSQKIEGSQGAPHNSGYDDEHGSYIRVLHDHIAYRFEVLEVIGKGSFGQVLKCLDHKTNELVAIKMIRNKKRFHHQALVELKILEVIKKKDKDNL--HNVIHMKEYFYFRNHLCISFELLGVNLYELIKKNNFQGFSLALIRRFAHALLRCLQMLHKEKIIHCDLKPENILLSQRGPGNIKVVDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELHTGYPLFPGESEVEQIACIMEVLGMPPNDFVQSASRRKLFFDSKGNPRNITNSKGKKRRPNSKELSAALK-TTDPLFLEFIKGCLTWDPTKRMTPDEGLQHQWI 511
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 395.586 bits (1015), Expect = 3.533e-130 Identity = 196/385 (50.91%), Postives = 259/385 (67.27%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
P+ P AL+ YR QL+ +E EI + ++F+G N+KK A+ G S N GYDDE G YI VPHDH+A+RYE L+ +GKGSFGQV K DH+ ++A+K++RN+KRFH+Q+ E+ IL+HL +++R + +V+H+L +F FRNH C+ FELL NLY++IKRN F+GFSL ++K ++SIL CL L R IIHCDLKPENIL+ S IK+IDFGSSCF ++++YTYIQSRFYR+PEVILG Y ID+WSFGC+L ELLTG PLFPGE E DQL C ME+ +PP VLE++ R K F ++KG PR L S+ R R P S+ +K D F+D I CL+WD R+ P AL+H W
Sbjct: 91 PLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRN--GTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATVLTGSRSRRGKMRGPPASKDWNVALKGCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWL 473
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 395.971 bits (1016), Expect = 1.440e-129 Identity = 196/385 (50.91%), Postives = 259/385 (67.27%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
P+ P AL+ YR QL+ +E EI + ++F+G N+KK A+ G S N GYDDE G YI VPHDH+A+RYE L+ +GKGSFGQV K DH+ ++A+K++RN+KRFH+Q+ E+ IL+HL +++R + +V+H+L +F FRNH C+ FELL NLY++IKRN F+GFSL ++K ++SIL CL L R IIHCDLKPENIL+ S IK+IDFGSSCF ++++YTYIQSRFYR+PEVILG Y ID+WSFGC+L ELLTG PLFPGE E DQL C ME+ +PP VLE++ R K F ++KG PR L S+ R R P S+ +K D F+D I CL+WD R+ P AL+H W
Sbjct: 149 PLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRN--GTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATVLTGSRSRRGKMRGPPASKDWNVALKGCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWL 531
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Medaka
Match: dyrk3 (dual specificity tyrosine-phosphorylation-regulated kinase 2 [Source:NCBI gene;Acc:101157613]) HSP 1 Score: 395.971 bits (1016), Expect = 1.440e-129 Identity = 196/385 (50.91%), Postives = 259/385 (67.27%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWF 1702
P+ P AL+ YR QL+ +E EI + ++F+G N+KK A+ G S N GYDDE G YI VPHDH+A+RYE L+ +GKGSFGQV K DH+ ++A+K++RN+KRFH+Q+ E+ IL+HL +++R + +V+H+L +F FRNH C+ FELL NLY++IKRN F+GFSL ++K ++SIL CL L R IIHCDLKPENIL+ S IK+IDFGSSCF ++++YTYIQSRFYR+PEVILG Y ID+WSFGC+L ELLTG PLFPGE E DQL C ME+ +PP VLE++ R K F ++KG PR L S+ R R P S+ +K D F+D I CL+WD R+ P AL+H W
Sbjct: 149 PLTPDQALRLYRSQLSPMELSEIHSYPDVYFVGPNAKKRPAVAGGSNNCGYDDEQGGYIHVPHDHLAYRYEFLKIIGKGSFGQVAKVYDHKLQQHLALKMVRNEKRFHRQAQEEIRILEHLHKQDRN--GTMNVVHMLENFTFRNHICMTFELLSMNLYELIKRNKFQGFSLPLVRKFAHSILQCLEALSRHRIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQRVYTYIQSRFYRAPEVILGSRYGLPIDMWSFGCILAELLTGYPLFPGEDESDQLACAMELLGMPPLKVLEQAKRAKNFINSKGHPRYCGYNTLPTGATVLTGSRSRRGKMRGPPASKDWNVALKGCEDPTFIDFIKKCLDWDPLSRLTPSQALRHPWL 531
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Planmine SMEST
Match: SMESG000042374.1 (SMESG000042374.1) HSP 1 Score: 1236.09 bits (3197), Expect = 0.000e+0 Identity = 623/629 (99.05%), Postives = 624/629 (99.21%), Query Frame = 2
Query: 86 MLPVPQLLGNIHNGRNYNTTKLGKGQRHLQFNFNSQQMNIPNTSNKTKQISINYPTFPMFDNFKSIHDISNQETNCDGHTQRXXXXXXXXXIRDIFKNSNGMNKNLFEPNNFITKKRVSNLSSINQKPSWGSVNISQSNCVDDSSRSTNQLDSSLKVSPHNYQDHSPHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHANDDCFKENQNSDIKPPLKRPRHRFQNRDKIQFKQLREFNSHYKPNGYLPPIQIGSNKKIENPVSENLQFIEDVMFNKTEFPSLYR 1972
MLPVPQLLGNIHN RNYNTTKLGKGQRHLQFNFNSQQMNIPNTSNKTKQISINYPTFPMFDNFKSIHD+SNQETNCDGHTQRNQKQNNNKNIRDIFKNSNGMNKNLFEPNNFITKKRVSNLSSINQKPSWGSVNI QSNCVDDSSRSTNQLDSSLKVSPHNYQDHSPHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNILKHLKEKERKLETSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHANDDCFKENQNSDIKPPLKRPRHR NRDKIQFKQ REFNSHYKPNGYLPPIQIGSNKKIENPVSENLQFIEDVMFNKTEFPSLYR
Sbjct: 1 MLPVPQLLGNIHNDRNYNTTKLGKGQRHLQFNFNSQQMNIPNTSNKTKQISINYPTFPMFDNFKSIHDMSNQETNCDGHTQRNQKQNNNKNIRDIFKNSNGMNKNLFEPNNFITKKRVSNLSSINQKPSWGSVNIYQSNCVDDSSRSTNQLDSSLKVSPHNYQDHSPHGFPMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNILKHLKEKERKLETSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNSKGRRRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQDFHANDDCFKENQNSDIKPPLKRPRHRIPNRDKIQFKQSREFNSHYKPNGYLPPIQIGSNKKIENPVSENLQFIEDVMFNKTEFPSLYR 629
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Planmine SMEST
Match: SMESG000081181.1 (SMESG000081181.1) HSP 1 Score: 379.407 bits (973), Expect = 8.644e-124 Identity = 188/397 (47.36%), Postives = 266/397 (67.00%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR------------SLHNSKGR----RRVPNSQTIQSTMKMNADSK-----------FVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
P P A++ Y+ +LTS E +EI ++ Q++FLGL++ K I G N YDDE +YI VPHDHI++R+EIL+ +GKGSFGQV +A DH G VA+K++RN+KRF +Q+ E+ IL+HL+ ++ +V+HLL F FRNH C+ FELL NLY++IK+N F GFSL ++K +++IL CL +L R IIHCDLKPENIL+ S IK+IDFGSSC+ ++K+Y Y+QSRFYR+PEVILG Y ID+WS GC+L EL+TG PLFPGE E DQL CI+EV +PP S+LE S R ++FF ++G PR ++ K R R +P S+ +Q+++K+ D++ F+D + SCL W+ R+ P +AL+H+W +
Sbjct: 166 PQSPSVAMRLYKTKLTSYEHQEIFNYPQVYFLGLSANKRSGIIGGGNNCNYDDEQHSYIYVPHDHISYRFEILKIIGKGSFGQVVRAFDHMQGQLVALKIVRNEKRFARQALEEIKILEHLRHEDTD--NGHNVVHLLEHFTFRNHMCMTFELLSYNLYELIKKNKFHGFSLQLVRKFAHAILQCLDLLYRNRIIHCDLKPENILLKQTGRSGIKVIDFGSSCYDHQKVYNYVQSRFYRAPEVILGASYGLSIDMWSLGCILCELVTGYPLFPGEDEGDQLACIIEVLGMPPPSLLEISKRSRVFFTSRGFPRYCVIETDYNGQCAIKPGKSRRGKVRGLPGSRDLQTSLKLLDDNQIENSEYESKLDFLDFVKSCLMWNCEDRLIPREALRHNWLR 560
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Planmine SMEST
Match: SMESG000064198.1 (SMESG000064198.1) HSP 1 Score: 376.326 bits (965), Expect = 2.057e-123 Identity = 191/413 (46.25%), Postives = 267/413 (64.65%), Query Frame = 2
Query: 596 PMGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPR-------------------------SLHNSKGRRR-VPNSQTIQSTM-KMNAD----------------SKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
P+ P A++ Y +L++ E EI ++ QI+F+G N+KK I + NNGYDDE G+Y V HDH+++RYEIL+ LGKGSFGQV KA DH+TG+ VA+K++RN+KRF +Q+ E+ IL+ LK +++ + ++H+L F FRNH C+ FELL NLY +IK+N F+GFSL ++K +YSIL CL +L + +IHCDLKPENIL+ S IK+IDFGSSC+ +++IYTYIQSRFYR+PEVILG Y+ QID+WSFGC+L E+LTG PLFPGE EMDQL CI+EV +PP++ L++ R K FF +KG PR + +G+ R P S+++ S + MN D + F++ + CLEW R P +AL+H W +
Sbjct: 77 PLTPDQAMKLYMHRLSTFEHHEIFNYPQIYFVGHNAKKKHGISVGANNNGYDDEHGSYQHVAHDHVSYRYEILKILGKGSFGQVVKAYDHKTGMFVALKMVRNEKRFAKQALEEIKILEQLKIQDKDNNKN--IVHILEHFTFRNHVCMTFELLNINLYSLIKKNKFQGFSLLLVKKFAYSILVCLDLLHKNKVIHCDLKPENILLKQQGRSGIKVIDFGSSCYDHQRIYTYIQSRFYRAPEVILGGKYSVQIDMWSFGCILVEMLTGYPLFPGEDEMDQLACIIEVLGMPPQNFLDQCKRSKEFFCSKGYPRYCQLETETETQSGKTIINGVVFYLKGCKSKRGKYRGSPGSKSLASIVNAMNPDLNSDANIDSEIQLKDFTNFINFLLKCLEWVPDDRFTPKEALRHEWLR 487
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 376.711 bits (966), Expect = 7.140e-123 Identity = 187/385 (48.57%), Postives = 257/385 (66.75%), Query Frame = 2
Query: 599 MGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNS---------------KGR-RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
+ P SA++ + +LT+ E EI + I+F+G N+KK + G + N GYDD+ +YI V HDHIA+RYE+L+ LGKGSFGQV KA+DH+TG VA+K++RN+KRF +Q+ E+ +L+ LK+++ ++ +VIH+++ F FRNH C+ FELL NLY++IK+N F+GFSL ++K +YSIL CL +L R IIHCDLKPENIL+ S IK+IDFGSSC +++IYTYIQSRFYR+PEVILG Y ID+WSFGC+L EL TG P+FPGE E DQL CIME+ PP + + R K+FF ++ PR S +GR R P S+T+ + +K D F+D CL W R+ P +ALKH W +
Sbjct: 147 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPD--SNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILKGGRSKRGRFRGPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLR 529
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Planmine SMEST
Match: SMESG000058389.1 (SMESG000058389.1) HSP 1 Score: 376.711 bits (966), Expect = 7.485e-123 Identity = 187/385 (48.57%), Postives = 257/385 (66.75%), Query Frame = 2
Query: 599 MGPRSALQNYRFQLTSLEQEEISHFNQIWFLGLNSKKTEAIKGSSPNNGYDDETGAYIKVPHDHIAFRYEILETLGKGSFGQVFKAIDHQTGINVAVKVIRNKKRFHQQSFVEVNIXXXXXXXXXXXXTSFHVIHLLNSFFFRNHPCLVFELLGENLYDVIKRNNFRGFSLSSIQKMSYSILSCLSVLRRENIIHCDLKPENILVMNNNSSEIKIIDFGSSCFYNEKIYTYIQSRFYRSPEVILGIPYTTQIDIWSFGCLLPELLTGRPLFPGESEMDQLLCIMEVYDLPPKSVLEESTRKKLFFDNKGEPRSLHNS---------------KGR-RRVPNSQTIQSTMKMNADSKFVDLIHSCLEWDARVRIQPDDALKHSWFQ 1705
+ P SA++ + +LT+ E EI + I+F+G N+KK + G + N GYDD+ +YI V HDHIA+RYE+L+ LGKGSFGQV KA+DH+TG VA+K++RN+KRF +Q+ E+ +L+ LK+++ ++ +VIH+++ F FRNH C+ FELL NLY++IK+N F+GFSL ++K +YSIL CL +L R IIHCDLKPENIL+ S IK+IDFGSSC +++IYTYIQSRFYR+PEVILG Y ID+WSFGC+L EL TG P+FPGE E DQL CIME+ PP + + R K+FF ++ PR S +GR R P S+T+ + +K D F+D CL W R+ P +ALKH W +
Sbjct: 150 LSPDSAMRQFMSKLTTYEHHEIFSYPSIFFVGTNAKKRAGVLGGTNNCGYDDDQNSYIHVAHDHIAYRYEVLKLLGKGSFGQVVKALDHKTGECVAIKMVRNEKRFTRQAAEEIRLLELLKKQDPD--SNCNVIHIIDQFIFRNHVCMTFELLSINLYELIKKNKFQGFSLQLVRKFAYSILLCLELLYRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCCEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSFGCILAELYTGYPIFPGEDEGDQLACIMEILGQPPTKLTDICKRTKIFFTSQRYPRYCVQSTDADGSVILKGGRSKRGRFRGPPASKTLSTALKNCDDQLFLDFTLRCLTWIPETRMTPKEALKHPWLR 532 The following BLAST results are available for this feature:
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Dual specificity tyrosine-phosphorylation-regulated kinase 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30015820 ID=SMED30015820|Name=Dual specificity tyrosine-phosphorylation-regulated kinase 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1995bpback to top protein sequence of SMED30015820-orf-1 >SMED30015820-orf-1 ID=SMED30015820-orf-1|Name=SMED30015820-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=630bp MLPVPQLLGNIHNGRNYNTTKLGKGQRHLQFNFNSQQMNIPNTSNKTKQIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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