Trans-L-3-hydroxyproline dehydratase

Overview
NameTrans-L-3-hydroxyproline dehydratase
Smed IDSMED30015802
Length (bp)1142
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Trans-L-3-hydroxyproline dehydratase (SMED30015802) t-SNE clustered cells

Violin plots show distribution of expression levels for Trans-L-3-hydroxyproline dehydratase (SMED30015802) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Trans-L-3-hydroxyproline dehydratase (SMED30015802) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Trans-L-3-hydroxyproline dehydratase (SMED30015802) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30015802

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30015802SMESG000021283.1 dd_Smed_v4_7144_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30015802SMESG000021283.1 dd_Smed_v4_7144_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30015802SMESG000021283.1 dd_Smed_v4_7144_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30015802SMESG000021283.1 dd_Smed_v4_7144_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30015802SMESG000021283.1 Contig37903newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30015802SMESG000021283.1 Contig37903uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
epidermisSMED30015802SMESG000021283.1 dd_Smed_v4_7144_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Human
Match: L3HYPDH (trans-L-3-hydroxyproline dehydratase [Source:HGNC Symbol;Acc:HGNC:20488])

HSP 1 Score: 220.705 bits (561), Expect = 2.693e-68
Identity = 122/347 (35.16%), Postives = 196/347 (56.48%), Query Frame = 2 
Query:   89 LETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIP----ETTIRMDCLCGLVILFVEW-DGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNC-ELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            L   +MHT GEP+RI+ +  P++  P    +L K+++  ++ D +R+ LM EPRGH+DM+G ++  P+E   + +G+LFL+  GY+SMCGHA +A+GR+ L+  L+ P  P    E  + + C CGLV  FV   DG   G  +FHSVPAFVL  +  V +P     +  DI YGG FYA ++ + L     S+    +++   ++ + ++  F+          +LYG ++T+  +      T  +C+F +E VDRSP GSG TA IA  Y    L L + +  ++   G  S FTG  ++E     + C + K + V++SG+A++ G ++F  E+DD  + GF L
Sbjct:   20 LSVVDMHTGGEPLRIVLAGCPEVSGPT---LLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLV-PSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLV-PAPPAGTREARVNIHCPCGLVTAFVACEDGRSHGPVRFHSVPAFVLATDLMVDVPG-HGKVMVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKSSATG--SVFTGKAVRE-----AKCGDFKAVIVEVSGQAHYTGTASFIIEDDDPLRDGFLL 353
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Human
Match: L3HYPDH (trans-L-3-hydroxyproline dehydratase [Source:HGNC Symbol;Acc:HGNC:20488])

HSP 1 Score: 73.1738 bits (178), Expect = 5.006e-15
Identity = 40/133 (30.08%), Postives = 67/133 (50.38%), Query Frame = 2 
Query:  584 DIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKE 976
            DI YGG FYA ++ + L     S+    +++   ++ + ++  F+          +LYG ++T+  +      T  +C+F +E VDRSP GSG TA IA  Y    L L + +  ++   G  S FTG  ++E
Sbjct:   13 DIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKSSATG--SVFTGKAVRE 143
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Human
Match: L3HYPDH (trans-L-3-hydroxyproline dehydratase [Source:HGNC Symbol;Acc:HGNC:20488])

HSP 1 Score: 70.8626 bits (172), Expect = 2.769e-14
Identity = 39/132 (29.55%), Postives = 66/132 (50.00%), Query Frame = 2 
Query:  584 DIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLK 973
            DI YGG FYA ++ + L     S+    +++   ++ + ++  F+          +LYG ++T+  +      T  +C+F +E VDRSP GSG TA IA  Y    L L + +  ++   G  S FTG  ++
Sbjct:   13 DIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKSSATG--SVFTGKAVR 142
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Zebrafish
Match: l3hypdh (trans-L-3-hydroxyproline dehydratase [Source:ZFIN;Acc:ZDB-GENE-170412-1])

HSP 1 Score: 224.557 bits (571), Expect = 3.704e-70
Identity = 119/345 (34.49%), Postives = 195/345 (56.52%), Query Frame = 2 
Query:   80 GYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLIT-PDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            G  L   +MHT GEP+RI+ S  P+++      IL K+++  E+ D +R++LMLEPRGH DM+G ++ + +E + +D+G+LFL+  GY++MCGHA IA+GR+ ++  L+  P  PET I + C CGLV  F ++   K G  +FHSVPAF    +  VS+  +   +  DI YGG  YA +S +        S    +++   ++ + ++   +    +     +LYG ++T+  +  +   T  +C+F +  VDRSP GSG TA +A  Y    + L + +  ++   G  S FTG  ++E    T+  + K + V++ G A+++G +TFT E DD    GF L
Sbjct:   11 GSVLSVVDMHTGGEPLRIILSGFPEVQ---GDTILAKRRYVREHLDHLRKVLMLEPRGHNDMYGALLVK-SELAEADLGVLFLHNEGYSTMCGHAVIALGRFAVDYGLVKEPTSPETQINIHCPCGLVKAFTQYADGKTGAVRFHSVPAFAFATDVSVSVEGYG-TVTVDISYGGALYAFVSAEKFGLDVNKSKTRDLVDAATAVSEAVKSQVKLYHPVSEDLAFLYGTILTDGKDAFSEEPTANMCVFADAQVDRSPTGSGVTARVALQYHKGLIRLNQTRSFQSGATG--SVFTGTAIEE----TTCGDFKAVVVEVKGHAHYSGVATFTQESDDPLSGGFLL 344
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Xenopus
Match: prss16 (serine protease 16 [Source:Xenbase;Acc:XB-GENE-5903844])

HSP 1 Score: 229.565 bits (584), Expect = 6.096e-72
Identity = 121/346 (34.97%), Postives = 195/346 (56.36%), Query Frame = 2 
Query:   77 NGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLI-TPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            +G  L   +MHT GEP+RI+ S  P    P+   IL K+++  EN D++R++LM EPRGH+DM+G ++  P +   ++IG+LF++  GY++MCGHA IA+GR+ ++  L+     PET + + C CGL+  +V + G + G  +F SVPAF    +  V +P +   +  DI YGG FYA +S +       SS    +++   ++ ++++   +      +   +LYG ++T+  +  +   T  +CIF E  VDRSP GSG TA IA  Y    + L + +  ++   G  S FTG  +KE +        K + V++SG+AY+ G S+F  E +D  K GF L
Sbjct:   13 DGPMLSVVDMHTGGEPLRIVLSGAPA---PEGRTILEKRRWVRENADWLRKVLMFEPRGHRDMYGALLV-PGDEEEANIGVLFMHNEGYSTMCGHAIIALGRFAVDYGLVNAAQGPETAVNIQCPCGLIRAYVSYTGGRSGSVRFRSVPAFAFATDVTVDVPGYG-KVVVDIAYGGAFYAFVSAETFGLDVCSSRTRDLVDVSAAVTESVKAQVKLNHPDSDDLAFLYGTILTDGKDSYSEEPTANICIFAESQVDRSPTGSGVTARIALQYHKGLIQLEQIRTFKSGATG--SLFTGKAVKETLC----GNFKAVVVEVSGQAYYTGASSFVIENEDSLKDGFLL 347
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Xenopus
Match: prss16 (serine protease 16 [Source:Xenbase;Acc:XB-GENE-5903844])

HSP 1 Score: 203.756 bits (517), Expect = 2.969e-62
Identity = 106/303 (34.98%), Postives = 172/303 (56.77%), Query Frame = 2 
Query:   77 NGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLI-TPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKE 976
            +G  L   +MHT GEP+RI+ S  P    P+   IL K+++  EN D++R++LM EPRGH+DM+G ++  P +   ++IG+LF++  GY++MCGHA IA+GR+ ++  L+     PET + + C CGL+  +V + G + G  +F SVPAF    +  V +P +   +  DI YGG FYA +S +       SS    +++   ++ ++++   +      +   +LYG ++T+  +  +   T  +CIF E  VDRSP GSG TA IA  Y    + L + +  ++   G  S FTG  +KE
Sbjct:   13 DGPMLSVVDMHTGGEPLRIVLSGAPA---PEGRTILEKRRWVRENADWLRKVLMFEPRGHRDMYGALLV-PGDEEEANIGVLFMHNEGYSTMCGHAIIALGRFAVDYGLVNAAQGPETAVNIQCPCGLIRAYVSYTGGRSGSVRFRSVPAFAFATDVTVDVPGYG-KVVVDIAYGGAFYAFVSAETFGLDVCSSRTRDLVDVSAAVTESVKAQVKLNHPDSDDLAFLYGTILTDGKDSYSEEPTANICIFAESQVDRSPTGSGVTARIALQYHKGLIQLEQIRTFKSGATG--SLFTGKAVKE 308
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Mouse
Match: L3hypdh (L-3-hydroxyproline dehydratase (trans-) [Source:MGI Symbol;Acc:MGI:1914467])

HSP 1 Score: 224.172 bits (570), Expect = 8.396e-70
Identity = 124/347 (35.73%), Postives = 197/347 (56.77%), Query Frame = 2 
Query:   89 LETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIP----ETTIRMDCLCGLVILFVEWDGVK-IGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNC-ELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            L   +MHT GEP+RI+ +  P++  P    +L K+++  ++ D+IR+ L+ EPRGH+DM+G I+  P+E   + +G+LFL+  GY+SMCGHA +A+GR+ L+  L+ P  P    E  + + C CGLV  FVE +G +  G  +FHSVPAFVL  +  V +P     L  DI YGG FYA +S + L     S+    +++   +L   ++  F+          +LYG ++T+  +  +   T  +C+F +E VDRSP GSG TA IA  Y    L L + +  ++   G  S FTG  ++E     + C + K + V+++G+A++ G +  T E+ D  + GF L
Sbjct:   20 LSVVDMHTGGEPLRIVHAGCPEVAGPT---LLAKRRYMRQHLDYIRRRLVFEPRGHRDMYGAILV-PSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLV-PAPPKGAREAQVNIHCPCGLVTAFVECEGGRSCGPVRFHSVPAFVLASDLTVDVPGHGKVL-VDIAYGGAFYAFVSAEKLGLDVCSAKTRDLVDAASALTGAVKAQFKINHPESEDLGFLYGSILTDGKDAYSEEATTNICVFADEQVDRSPTGSGVTARIALQYHKGLLQLNQTRAFKSSATG--SVFTGCAVRE-----AKCGDFKAVIVEVAGQAHYTGTANLTVEDGDPLRDGFLL 353
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. UniProt/SwissProt
Match: sp|P0DKB4|T3HPD_SACKO (Trans-L-3-hydroxyproline dehydratase OS=Saccoglossus kowalevskii OX=10224 GN=l3hypdh PE=1 SV=1)

HSP 1 Score: 229.565 bits (584), Expect = 1.783e-71
Identity = 123/336 (36.61%), Postives = 186/336 (55.36%), Query Frame = 2 
Query:  104 MHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            MHT GEP+RI+    PK   PD   IL K++F  E  D  R++LM EPRGH DM+G ++ EP+    +DI +LF++   Y++MCGHA IA+GRY  +   + P  PET + ++C CGLV   VE+   K G  +F SVPAFV   + E+++ Q    +K DI YGG FYA IS   L      +   +I +    +   ++   +      N   ++YG ++T+  +  +   T  +C+F +  VDRSP GSG TA  A  Y  + + L + ++  N  +G  S F+  P+++    T       + +++SG A++ GKS FT+EEDD  K GF L
Sbjct:    1 MHTGGEPLRIVTDGFPK---PDGKTILQKRRFVKEKLDNFRKLLMHEPRGHYDMYGALLVEPDIED-ADIAVLFMDNRSYSTMCGHAVIALGRYATDYGYVRPTEPETKVNIECPCGLVKALVEYKNGKSGSVRFQSVPAFVFATDVELNV-QGHGKVKVDISYGGAFYAFISADKLGLDLWKTPINQIKDAATMVTNAVKNEVQLEHPDDNDLAFIYGTIVTDGKDEYSDEPTANICVFADAQVDRSPTGSGVTARTALQYHKRHISLNKSRVFVNARIG--SKFSAKPVRQ----TKCGSYDAVIIEVSGHAFYTGKSAFTFEEDDPLKGGFLL 325
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. UniProt/SwissProt
Match: sp|Q3SX04|T3HPD_BOVIN (Trans-L-3-hydroxyproline dehydratase OS=Bos taurus OX=9913 GN=L3HYPDH PE=2 SV=1)

HSP 1 Score: 228.794 bits (582), Expect = 1.044e-70
Identity = 124/346 (35.84%), Postives = 198/346 (57.23%), Query Frame = 2 
Query:   89 LETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITP---DIPETTIRMDCLCGLVILFVEWDGVKI-GKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNC-ELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            L   +MHT GEP+RI+ +  P++  P    +L K+++  ++ D +R+ LM EPRGH+DM+G ++  P+E   + +G+LFLN  GY+SMCGHA +A+GR+ L+  L+     D  E  + + C CGLV  FVE +G +  G  +FHSVPAFVL  ++ V +P     +  DI YGG FYA +S + L     S+    ++    ++ + ++  F+          +LYG ++T+  +  N   T  +C+F +E VDRSP GSG TA IA  Y    L L + +  ++   G  S FTG  ++E     + C + K + V++SG+A++ G ++F  E+DD  + GF L
Sbjct:   20 LSVVDMHTGGEPLRIVLAGCPEVVGPT---LLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLV-PSELPDAHLGVLFLNNEGYSSMCGHAVLALGRFALDFGLVPAPPSDAQEALVNIHCPCGLVAAFVECEGCRSRGPVRFHSVPAFVLATDFLVDVPG-RGKVVVDIAYGGAFYAFVSAEKLGLDVCSAKMGDLVAAASAVTEAVKAQFKISHPDSEDLAFLYGTILTDGKDTYNEEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQTRAFKSSATG--SVFTGKAVRE-----AKCGDFKAVIVEVSGQAHYTGTASFIVEDDDPLRDGFLL 353
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. UniProt/SwissProt
Match: sp|Q66II5|T3HPD_XENTR (Trans-L-3-hydroxyproline dehydratase OS=Xenopus tropicalis OX=8364 GN=l3hypdh PE=2 SV=1)

HSP 1 Score: 228.024 bits (580), Expect = 1.293e-70
Identity = 120/346 (34.68%), Postives = 194/346 (56.07%), Query Frame = 2 
Query:   77 NGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLI-TPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            +G  L   +MHT GEP+RI+ S  P    P+   IL K+++  EN D++R++LM EPRGH+DM+G ++  P +   ++IG+LF++  GY++MCGHA +A+GR+ ++  L+     PET + + C CGL+  +V + G + G  +F SVPAF    +  V +P +   +  DI YGG FYA +S +       SS    +++   ++ ++++   +      +   +LYG ++T+  +  +   T  +CIF E  VDRSP GSG TA IA  Y    + L + +  ++   G  S FTG  +KE +        K + V++SG+AY+ G S+F  E  D  K GF L
Sbjct:   13 DGPMLSVVDMHTGGEPLRIVLSGAPA---PEGRTILEKRRWVRENADWLRKVLMFEPRGHRDMYGALLV-PGDEEEANIGVLFMHNEGYSTMCGHAIVALGRFAVDYGLVNAAQGPETAVNIQCPCGLIRAYVSYTGGRSGSVRFRSVPAFAFATDVTVDVPGYG-KVVVDIAYGGAFYAFVSAETFGLDVCSSRTRDLVDVSAAVTESVKAQVKLNHPDSDDLAFLYGTILTDGKDSYSEEPTANICIFAESQVDRSPTGSGVTARIALQYHKGLIQLEQIRTFKSGATG--SLFTGKAVKETLC----GNFKAVVVEVSGQAYYTGASSFVIENKDSLKDGFLL 347
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. UniProt/SwissProt
Match: sp|Q9CXA2|T3HPD_MOUSE (Trans-L-3-hydroxyproline dehydratase OS=Mus musculus OX=10090 GN=L3hypdh PE=1 SV=1)

HSP 1 Score: 224.172 bits (570), Expect = 5.873e-69
Identity = 124/347 (35.73%), Postives = 197/347 (56.77%), Query Frame = 2 
Query:   89 LETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIP----ETTIRMDCLCGLVILFVEWDGVK-IGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNC-ELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            L   +MHT GEP+RI+ +  P++  P    +L K+++  ++ D+IR+ L+ EPRGH+DM+G I+  P+E   + +G+LFL+  GY+SMCGHA +A+GR+ L+  L+ P  P    E  + + C CGLV  FVE +G +  G  +FHSVPAFVL  +  V +P     L  DI YGG FYA +S + L     S+    +++   +L   ++  F+          +LYG ++T+  +  +   T  +C+F +E VDRSP GSG TA IA  Y    L L + +  ++   G  S FTG  ++E     + C + K + V+++G+A++ G +  T E+ D  + GF L
Sbjct:   20 LSVVDMHTGGEPLRIVHAGCPEVAGPT---LLAKRRYMRQHLDYIRRRLVFEPRGHRDMYGAILV-PSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLV-PAPPKGAREAQVNIHCPCGLVTAFVECEGGRSCGPVRFHSVPAFVLASDLTVDVPGHGKVL-VDIAYGGAFYAFVSAEKLGLDVCSAKTRDLVDAASALTGAVKAQFKINHPESEDLGFLYGSILTDGKDAYSEEATTNICVFADEQVDRSPTGSGVTARIALQYHKGLLQLNQTRAFKSSATG--SVFTGCAVRE-----AKCGDFKAVIVEVAGQAHYTGTANLTVEDGDPLRDGFLL 353
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. UniProt/SwissProt
Match: sp|Q5RC28|T3HPD_PONAB (Trans-L-3-hydroxyproline dehydratase OS=Pongo abelii OX=9601 GN=L3HYPDH PE=2 SV=1)

HSP 1 Score: 221.476 bits (563), Expect = 7.015e-68
Identity = 122/347 (35.16%), Postives = 195/347 (56.20%), Query Frame = 2 
Query:   89 LETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIP----ETTIRMDCLCGLVILFVEW-DGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNC-ELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            L   +MHT GEP+RI+ +  P++  P    +L K+++  ++ D +R+ LM EPRGH+DM+G ++  P+E   + +G+LFL+  GY+SMCGHA +A+GR+ L+  L+ P  P    E  + + C CGLV  FV   DG   G  +FHSVPAFVL  +  V +P     +  DI YGG FYA ++ + L     S+    +++   ++ K ++  F+          +LYG ++T+  +      T  +C+F +E VDRSP GSG  A IA  Y    L L + +  ++   G  S FTG  ++E     + C + K + V++SG+A++ G ++F  E+DD  + GF L
Sbjct:   20 LSVVDMHTGGEPLRIVLAGCPEVSGPT---LLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLV-PSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLV-PATPAGTREARVNIHCPCGLVTAFVACEDGRSHGPVRFHSVPAFVLATDLMVDVPG-HGKVVVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTKAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSGVIARIALQYHKGLLELNQTRAFKSSATG--SVFTGKAVRE-----AKCGDFKAVIVEVSGQAHYTGTASFIVEDDDPLRDGFLL 353
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. TrEMBL
Match: A0A3M6V367 (Uncharacterized protein OS=Pocillopora damicornis OX=46731 GN=pdam_00021555 PE=4 SV=1)

HSP 1 Score: 240.736 bits (613), Expect = 5.579e-73
Identity = 128/353 (36.26%), Postives = 204/353 (57.79%), Query Frame = 2 
Query:   77 NGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIPETTIR-----MDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITE-----NHENSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            NG ++ T EMHT GEP+RI+ S  P+I+      IL K+++  EN D +R++LM EPRGH DM+G ++ +P+    +D+G++F++  GY++MCGHA IA+GRY ++  L++ D+  +++      ++C CG+V   V+ +  K G+ +F SVPAF    + E++  +F   +K DI +GG FYAI+    L     SS    I+E   ++    +   +          +LYG +IT+     N ++   T  +C+F +  VDRSP GSG TA IA  Y  Q++ L + ++    L+G  S FTG  +KE    T   +   + V+++G AY+ GK TFT E+DD F+ GF L
Sbjct:    4 NGLEISTIEMHTGGEPLRIIASGFPEIK---GDTILDKRRYVRENLDHLRKLLMFEPRGHYDMYGAVIVQPHSEM-ADLGVIFMHNEGYSTMCGHAVIALGRYAVDSGLLSTDVSRSSVGEVPVFIECPCGVVKALVDIEEGKSGRVRFVSVPAFAFGLDVELNTEKFG-QVKVDIGFGGAFYAIVPAHRLGVDVRSSRLADIVEAANAITNAGKSQIKLHHPDSEELAFLYGTIITDGKDMFNSDSKEATANVCVFADSEVDRSPTGSGVTARIAVQYARQQIGLHQMRVFEQGLVG--SQFTGQAVKE----TKVGDFDAVHVEVAGNAYYTGKCTFTVEKDDPFRDGFLL 345
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. TrEMBL
Match: A0A1S3J6Y6 (trans-L-3-hydroxyproline dehydratase-like OS=Lingula unguis OX=7574 GN=LOC106170725 PE=4 SV=1)

HSP 1 Score: 239.195 bits (609), Expect = 2.033e-72
Identity = 131/344 (38.08%), Postives = 200/344 (58.14%), Query Frame = 2 
Query:   89 LETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLI--TPDIPETTIRMDCLCGLVILFVEWDGV-KIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            ++T EMHT GEP+RI+ES  PKI       IL K+KF  ENFDF+R+ LM EPRGH DM+G ++ EP+ N  +D+ +LF++  GY++MCGHA IA+GRY L+K L    P  PET + + C CGLV  FVE + + + G+ +FHSVP+F+   + +VS+P +   L+ DI YGG FYA ++T+ L   F ++   +I++    + + ++ + +          +LYG ++T+  E  +   T  +C+F +  VDR P GSG TA IA  +    + + +++   N   G  S FTG  ++     T +     + V++SG  Y+ G  TF  E  D  K GF L
Sbjct:   17 IKTTEMHTGGEPLRIVESGYPKI---SGETILEKRKFVKENFDFLRKFLMFEPRGHFDMYGALLIEPD-NPEADMAVLFMHNEGYSTMCGHAVIALGRYALDKGLARHKPSPPETEVNIQCPCGLVKAFVECNHLGETGRVRFHSVPSFLFAADVKVSVPGYG-ELQVDIAYGGAFYAFVTTEALGLNFQTNKTSEIVDAASKVTEAVKSTVKLHHPDSPDLAFLYGTIVTDGKEEFSQEPTANICVFADRQVDRCPTGSGVTARIALQFAKGLISIDQERAFENGCTG--SRFTGKAIRSCKAGTHD----AVVVEVSGNGYYTGSCTFIAEAKDMLKEGFIL 349
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. TrEMBL
Match: A0A1S3J6V6 (trans-L-3-hydroxyproline dehydratase OS=Lingula unguis OX=7574 GN=LOC106170700 PE=4 SV=1)

HSP 1 Score: 238.424 bits (607), Expect = 4.369e-72
Identity = 130/344 (37.79%), Postives = 200/344 (58.14%), Query Frame = 2 
Query:   89 LETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLI--TPDIPETTIRMDCLCGLVILFVEWDGV-KIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            ++T EMHT GEP+RI+ES  PKI       IL K+KF  ENFDF+R+ LM EPRGH DM+G ++ EP+ N  +D+ +LF++  GY++MCGHA IA+GRY L+K L    P  PET + + C CGLV  FVE + + + G+ +FHSVP+F+   + +VS+P +   L+ DI YGG FYA ++T+ L   F +    +I++    + + ++ + +          +LYG ++T+  E  +   T  +C+F +  VDR P GSG TA IA  +    + + ++++  +   G  S FTG  ++     T +     + V++SG  Y+ G  TF  E  D  K GF L
Sbjct:   17 IKTTEMHTGGEPLRIVESGYPKI---SGETILEKRKFVKENFDFLRKFLMFEPRGHFDMYGALLIEPD-NPEADMAVLFMHNEGYSTMCGHAVIALGRYALDKGLARHKPSPPETEVNIQCPCGLVKAFVECNHLGETGRVRFHSVPSFLFAADVKVSVPGYG-ELQVDIAYGGAFYAFVTTEALGLNFQTKKTSEIVDAASKVTEAVKSTVKLHHPDSPDLAFLYGTIVTDGKEEFSQEPTANICVFADRQVDRCPTGSGVTARIALQFAKGLISIDQERVFESGCTG--SRFTGKAIRSCKAGTHD----AVVVEVSGNGYYTGSCTFIAEAKDMLKEGFIL 349
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. TrEMBL
Match: A0A1B1JCG8 (Trans-L-3-hydroxyproline dehydratase-like protein OS=Saccoglossus kowalevskii OX=10224 PE=2 SV=1)

HSP 1 Score: 236.884 bits (603), Expect = 1.218e-71
Identity = 127/341 (37.24%), Postives = 191/341 (56.01%), Query Frame = 2 
Query:   89 LETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            + T EMHT GEP+RI+    PK   PD   IL K++F  E  D  R++LM EPRGH DM+G ++ EP+    +DI  LF++  GY++MCGHA IA+GRY ++   +TP  PET + ++C CGLV   VE+   K G  +F SVPAFV   + E+++ Q    +K DI YGG FYA IS   L      +   +I +    +   ++   +      N   ++YG ++T+  +  +   T  +C+F +  VDRSP GSG TA  A  Y  + + L + ++  N  +G  S F+  P+++    T       + +++SG A++ GKS FT+EEDD  K GF L
Sbjct:    3 INTVEMHTGGEPLRIITDGFPK---PDGKTILQKRRFVKEKLDNFRKLLMHEPRGHYDMYGALLVEPDIKD-ADIAALFIHNEGYSTMCGHAVIALGRYAIDYGHVTPTEPETKVNIECPCGLVRALVEYKNGKSGSVRFQSVPAFVFATDVELNV-QGHGKVKVDISYGGAFYAFISADKLGLDLWKTPINQIKDAATMVTNAVKNEVQLEHPDDNDLAFIYGTIVTDGKDEYSDEPTANICVFADAQVDRSPTGSGVTARTALQYHKRHISLNKSRVFVNARIG--SKFSAKPVRQ----TKCGSYDAVIIEVSGHAFYTGKSAFTFEEDDPLKGGFLL 332
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. TrEMBL
Match: A0A1S3MAE3 (trans-3-hydroxy-L-proline dehydratase isoform X1 OS=Salmo salar OX=8030 GN=l3hypdh PE=4 SV=1)

HSP 1 Score: 236.498 bits (602), Expect = 3.075e-71
Identity = 125/364 (34.34%), Postives = 206/364 (56.59%), Query Frame = 2 
Query:   23 MSLNN*LLQDKMEYNKILNGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLIT-PDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            M+LN+ +   KME      G  L   +MHT GEP+RI+ S  P+++      +L K+++  EN D++R++LM EPRGH DM+G ++ E +E   +D+G+LF++  GY++MCGHA IA+GR+ ++  L+  P  PET + + C CGLV  FVE+   K G  +FHSVPAF    +  V++P ++  +  DI YGG FYA +  +        S    +++   ++  +++   +          +LYG ++T+  +  +   T  +C+F +  VDRSP GSG TA +A  Y    + L + +  ++   G  S FTG  ++E    T+  + K + V+++GRA++ G ++F  E DD  K GF L
Sbjct:    1 MNLNSRIGSKKMELPP-HEGSVLSVVDMHTGGEPLRIILSGYPEVK---GEGVLSKRRYVRENLDYLRRVLMFEPRGHYDMYGALVVE-SEIPEADLGVLFMHNEGYSTMCGHAVIALGRFAVDYKLVQEPRSPETQVNIHCPCGLVKAFVEYSNGKTGGVRFHSVPAFAFATDVIVAVPGYD-EVTVDISYGGAFYAFVRAERFGLDINKSKTRDLVDAATAVTNSVKSQVKLHHPTSEDLAFLYGTILTDGKDAYSQEPTANMCVFADAQVDRSPTGSGVTARVALQYHKGLIQLNQTRTFQSGATG--SLFTGKAVQE----TTCGDFKAVVVEVAGRAHYTGVASFVQESDDKLKHGFLL 352
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Cavefish
Match: l3hypdh (trans-L-3-hydroxyproline dehydratase [Source:NCBI gene;Acc:103042342])

HSP 1 Score: 230.335 bits (586), Expect = 2.025e-72
Identity = 121/355 (34.08%), Postives = 204/355 (57.46%), Query Frame = 2 
Query:   56 MEYNKI--LNGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLI-TPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            ME+ K+   +G  L   +MHT GEP+R++ +  P++       +L K+++  E+ D +R++LM EPRGH DM+G ++ + +E + +DIG+LF++  GY++MCGHA IA+GR+ ++  L+ +P  PET I + C CGLV  FVE+   K G  +FHSVPAFV   + +V++P F   +  DI YGG  YA ++    +   + S    +++   ++   ++   +    + +   +LYG ++T+  +  +   T  +C+F +  VDRSP GSG TA IA  Y    + L + +  ++      + FTG  ++E    T+  E K + V+++G AY+ G ++FT E  D  K GF L
Sbjct:    1 MEFPKLPPHDGPVLSVVDMHTGGEPLRVIINGYPEVT---GDTVLAKRRYAREHLDHLRKVLMFEPRGHYDMYGALLVQ-SEIAEADIGVLFMHNEGYSTMCGHAVIALGRFAVDYGLVKSPTSPETQINIHCPCGLVKAFVEYSNGKTGAVRFHSVPAFVFATDVKVTVPGFG-EITVDISYGGALYAFVNADSFRMDVSKSRTRDLVDVATAVSNAVKSQVKLHHPVSDDLAFLYGTILTDGKDAFSDEPTANICVFADAQVDRSPTGSGVTARIALQYHKGLIQLHQTRSFKSGTT--EALFTGKAVQE----TTCGEFKAVVVEVAGHAYYTGAASFTLENSDLLKDGFLL 344
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Cavefish
Match: l3hypdh (trans-L-3-hydroxyproline dehydratase [Source:NCBI gene;Acc:103042342])

HSP 1 Score: 230.335 bits (586), Expect = 2.025e-72
Identity = 121/355 (34.08%), Postives = 204/355 (57.46%), Query Frame = 2 
Query:   56 MEYNKI--LNGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLI-TPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            ME+ K+   +G  L   +MHT GEP+R++ +  P++       +L K+++  E+ D +R++LM EPRGH DM+G ++ + +E + +DIG+LF++  GY++MCGHA IA+GR+ ++  L+ +P  PET I + C CGLV  FVE+   K G  +FHSVPAFV   + +V++P F   +  DI YGG  YA ++    +   + S    +++   ++   ++   +    + +   +LYG ++T+  +  +   T  +C+F +  VDRSP GSG TA IA  Y    + L + +  ++      + FTG  ++E    T+  E K + V+++G AY+ G ++FT E  D  K GF L
Sbjct:    1 MEFPKLPPHDGPVLSVVDMHTGGEPLRVIINGYPEVT---GDTVLAKRRYAREHLDHLRKVLMFEPRGHYDMYGALLVQ-SEIAEADIGVLFMHNEGYSTMCGHAVIALGRFAVDYGLVKSPTSPETQINIHCPCGLVKAFVEYSNGKTGAVRFHSVPAFVFATDVKVTVPGFG-EITVDISYGGALYAFVNADSFRMDVSKSRTRDLVDVATAVSNAVKSQVKLHHPVSDDLAFLYGTILTDGKDAFSDEPTANICVFADAQVDRSPTGSGVTARIALQYHKGLIQLHQTRSFKSGTT--EALFTGKAVQE----TTCGEFKAVVVEVAGHAYYTGAASFTLENSDLLKDGFLL 344
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Nematostella
Match: EDO30757 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZV9])

HSP 1 Score: 226.868 bits (577), Expect = 2.282e-71
Identity = 131/364 (35.99%), Postives = 200/364 (54.95%), Query Frame = 2 
Query:   44 LQDKMEYNKILNGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDI-----PETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHEN-----SNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            L+D   Y+ +  G ++ T EMHT GEP+RI+ S  P+I+      IL K++F  +N D++R+MLMLEPRGH DM+G ++ EP+  + +D+ +LFL+  GY  MCGHA IA+GRY ++  ++  D       E  + + C CG+V  FVE    K GK +F SVPAF    +  V   ++  P+K DI YGG FYAI+S   L     +      I+    + + ++   +          +LYGV+IT++++       + T  + +F + +VDR PCGSGTTA IA  Y  Q + L + ++         S F G  LKE    T   E   + V+++G A++ G  +F  E+DD  K+GF L
Sbjct:    7 LEDGGVYS-LEEGIQIRTVEMHTGGEPLRIITSGYPEIK---GETILQKRRFVRDNLDYLRKMLMLEPRGHADMYGALLVEPDAEN-ADMAVLFLHNEGYGLMCGHAIIALGRYAVDTGVVAVDTGSSSYGEVPVFIQCPCGVVKAFVELCEGKSGKVRFVSVPAFAFAIDLVVETDKYG-PVKLDIGYGGAFYAIVSGDKLGLDVKTCKVRDAIDAAAVISRAVKNQVKLTHPDSPDLAFLYGVIITDSNDRYSDDPDDCTKNITVFADNAVDRCPCGSGTTARIAVQYAKQLIGLNQLRLFEGM---SRSKFGGRVLKE----TKCGEFDAVHVEVAGHAFYTGSCSFRVEKDDDLKYGFLL 357
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Nematostella
Match: EDO35809 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKB9])

HSP 1 Score: 213.772 bits (543), Expect = 1.471e-66
Identity = 122/344 (35.47%), Postives = 186/344 (54.07%), Query Frame = 2 
Query:  104 MHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIP-----ETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHEN-----SNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            MHT GEP+RI+ S  P+I+      IL K++F  +N D++R+MLM EPRGH DM+G ++ EP+  + +D+ +LFL+  GY++MCGHA IA+GRY ++  ++  D       E  + + C CG+V  FVE    K GK +F SVPAF    +  V   ++  P+K DI YGG FYAI+S   L     +      I+    + + ++   +          +LYGV+IT++ +       + T  + +F +  VDR P GSG TA IA  Y  Q + L + ++         S F G  LKE    T   E   + V+++G A++ G  +F  E+DD  K+GF L
Sbjct:    1 MHTGGEPLRIITSGYPEIK---GETILQKRRFVRDNLDYLRKMLMFEPRGHADMYGALLVEPDAEN-ADMAVLFLHNEGYSTMCGHAIIALGRYAVDTGVVAVDTDSSSYGEVPVFIQCPCGVVKAFVELCEGKSGKVRFVSVPAFAFAIDLVVETDKYG-PVKLDIGYGGAFYAIVSGDKLGLDVKTCKVRDAIDAAAVISRAVKNQVKLTHPDSPELAFLYGVIITDSKDRYSDDPDDCTKNITVFADNQVDRCPTGSGVTARIAVQYAKQLIGLNQLRVFEGV---SGSKFGGRVLKE----TKCGEFDAVHVEVAGHAFYTGSCSFRVEKDDDLKYGFLL 332
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Nematostella
Match: EDO25484 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DWC5])

HSP 1 Score: 130.183 bits (326), Expect = 9.992e-36
Identity = 72/212 (33.96%), Postives = 114/212 (53.77%), Query Frame = 2 
Query:  227 QMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDI-----PETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHEN-----SNTTDVLCIFGEESV 832
            +MLMLEPRGH DM+G ++ EP+  + +D+ +LFL+  GY  MCGHA IA+GRY ++  ++  D       E  + + C CG+V  FVE    K GK +F SVPAF    +  V   ++  P+K DI YGG FYAI+S   L     +      I+    + + ++   +          +LYGV+IT++++       + T  + +F + +V
Sbjct:   13 KMLMLEPRGHADMYGALLVEPDAEN-ADMAVLFLHNEGYGLMCGHAIIALGRYAVDTGVVAVDTGSSSYGEVPVFIQCPCGVVKAFVELCEGKSGKVRFVSVPAFAFAIDLVVETDKYG-PVKLDIGYGGAFYAIVSGDKLGLDVKTCKVRDAIDAAAVISRAVKNQVKLTHPDSPDLAFLYGVIITDSNDRYSDDPDDCTKNITVFADNAV 222
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Nematostella
Match: EDO25964 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TD89])

HSP 1 Score: 52.373 bits (124), Expect = 7.719e-8
Identity = 49/243 (20.16%), Postives = 99/243 (40.74%), Query Frame = 2 
Query:  164 PDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNP------YLYGVLITENHENSNTTDVLCIFGEESVDRSPCGSGTTAIIA 874
            P   D L  +  +      +R  ++ EPRG      V +  P ++  + +  + +       M G  S+ +   +LE  ++    P+T + ++   GL+    +    K+ K +  +VP+F    +  + +      L+ D  YGG+ + I   + L     +     +   G+ + +   +   F   + NP+        L G L  ++   S    V+   G+  +DRSP G+G +A +A
Sbjct:   27 PPPGDTLWAQSRWIAEEQTLRNFMLNEPRGGV-FRHVNLLVPAKDPRAQMAWIIMEPADTPPMSGSNSLCVATVLLESGILPMTEPQTHLILEAPGGLIEAVAQCRNGKVEKVEIKNVPSFADRLDAWIEVDGIGS-LQVDTAYGGDSFVIADAQALGFSLGADEAADLAACGLKITRAANEQLGFVHPL-NPDWAHISFCQLAGPLQRQDGVLSAANAVVIRPGK--IDRSPTGTGCSARMA 264
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Medaka
Match: ENSORLT00000021808.2 (trans-L-3-hydroxyproline dehydratase [Source:NCBI gene;Acc:101166521])

HSP 1 Score: 212.231 bits (539), Expect = 3.899e-65
Identity = 120/368 (32.61%), Postives = 189/368 (51.36%), Query Frame = 2 
Query:   77 NGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLIT-PDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLN----------------------PNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
             G +    +MHT GEP+RI+ S  P+++      IL K+++  E+ D +R+ LM EPRGH DM+G ++ + +E   +D+ +LF++  GY++MCGHA IA+GR+ ++  L+  P  PET + + C CGLV  FVE+   K G+ +F SVPAFV                         +  V +  F   L  DI YGG FYA I  +      T S    +++   ++ K ++   +          +LYG ++T+  E  +   T  +C+F E  VDRSP GSG TA +A  Y    + + + +  ++   G  S FTG  ++E        + K + V++SGRA++ G S F  E +D    GF L
Sbjct:   11 QGGEFSVVDMHTGGEPLRIIVSGYPEVK---GDTILSKRRYAREHLDHLRRALMFEPRGHADMYGALIVD-SETPKADLAVLFMHNEGYSTMCGHAVIALGRFAVDYKLVKEPQTPETQVNILCPCGLVQAFVEYSDGKTGRVRFLSVPAFVFAEGAFLSTEGGPERFHIVTETFVADVPVEVEGFG-ELTVDISYGGAFYAFIDAQRFGLDVTKSRTRDLVDAATAVTKAVKSQVKLYHPCSEDLAFLYGTILTDGKEEYSPEPTANMCVFAEAQVDRSPTGSGVTARVALQYHKGLIQMNQTRTFQSGATG--SQFTGKAVQE----VECGDFKAVVVEVSGRAFYTGVSRFVQETEDQLTTGFLL 367
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Medaka
Match: ENSORLT00000041946.1 (trans-L-3-hydroxyproline dehydratase [Source:NCBI gene;Acc:101166521])

HSP 1 Score: 201.06 bits (510), Expect = 2.385e-61
Identity = 105/304 (34.54%), Postives = 168/304 (55.26%), Query Frame = 2 
Query:   77 NGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLIT-PDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHE--NSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKEN 979
             G +    +MHT GEP+RI+ S  P+++      IL K+++  E+ D +R+ LM EPRGH DM+G ++ + +E   +D+ +LF++  GY++MCGHA IA+GR+ ++  L+  P  PET + + C CGLV  FVE+   K G+ +F SVPAFV   +  V +  F   L  DI YGG FYA I  +      T S    +++   ++ K ++   +          +LYG ++T+  E  +   T  +C+F E  VDRSP GSG TA +A  Y    + + + +  ++   G  S FTG  ++ +
Sbjct:   11 QGGEFSVVDMHTGGEPLRIIVSGYPEVK---GDTILSKRRYAREHLDHLRRALMFEPRGHADMYGALIVD-SETPKADLAVLFMHNEGYSTMCGHAVIALGRFAVDYKLVKEPQTPETQVNILCPCGLVQAFVEYSDGKTGRVRFLSVPAFVFAEDVPVEVEGFG-ELTVDISYGGAFYAFIDAQRFGLDVTKSRTRDLVDAATAVTKAVKSQVKLYHPCSEDLAFLYGTILTDGKEEYSPEPTANMCVFAEAQVDRSPTGSGVTARVALQYHKGLIQMNQTRTFQSGATG--SQFTGKAVQSH 307
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Planmine SMEST
Match: SMESG000021283.1 (SMESG000021283.1)

HSP 1 Score: 721.079 bits (1860), Expect = 0.000e+0
Identity = 349/350 (99.71%), Postives = 350/350 (100.00%), Query Frame = 2 
Query:   56 MEYNKILNGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHENSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            MEYNKILNGYKLETCEMHTCGEPVRILESTEPKI+FPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHENSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL
Sbjct:    1 MEYNKILNGYKLETCEMHTCGEPVRILESTEPKIKFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHENSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 350
[Close]
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Planmine SMEST
Match: SMESG000021281.1 (SMESG000021281.1)

HSP 1 Score: 389.808 bits (1000), Expect = 6.545e-135
Identity = 181/343 (52.77%), Postives = 240/343 (69.97%), Query Frame = 2 
Query:   77 NGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFSENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMCGHASIAIGRYMLEKNLITPDIPETTIRMDCLCGLVILFVEWDGVKIGKTKFHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSSNKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHENSNTTDVLCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNFTGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL 1105
            NG  ++TCEMH CGEPVRILE+ EP + FP  SDIL K+K+FSENFDFIR+MLMLEPRGH +M GV++TEPN +SGSD G+LF+NT+    MCGH +I +GRY+LEKNLI   IPET I+ DC CGLV++ VEWDG  +G TK  +VP+FV   +YEV I +    +KCDI +GGNF+AIIS  +L   F +  +  IIE GI L+ TL+K F F   +     YLY  +I E ++++     LC++GE   DRSPCGSG+TA+    YF +KL L +  +T+N  LG+HS F   P +E  +IT N  +K + V+ISGRA+F G+  FT+EE+D FK+GFN+
Sbjct:    8 NGLNIQTCEMHCCGEPVRILETIEPSLNFPKDSDILQKRKYFSENFDFIRKMLMLEPRGHGNMLGVLLTEPNPSSGSDYGLLFMNTVDLLPMCGHMTIGVGRYLLEKNLIKKQIPETVIKFDCPCGLVVVSVEWDGTTVGNTKMLNVPSFVEKMDYEVIISELGRKVKCDIAFGGNFFAIISANELGVNFENDAQSVIIEKGILLLNTLKKQFCFSHLVSKEIEYLYAAIIIEKNDSNQRVKQLCVYGENLFDRSPCGSGSTAVTTCQYFRKKLQLNQTMVTQNAFLGEHSTFFATPKEEKEIITENGNIKSLLVEISGRAFFTGECNFTFEENDFFKYGFNI 350
The following BLAST results are available for this feature:
BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
L3HYPDH2.693e-6835.16trans-L-3-hydroxyproline dehydratase [Source:HGNC ... [more]
L3HYPDH5.006e-1530.08trans-L-3-hydroxyproline dehydratase [Source:HGNC ... [more]
L3HYPDH2.769e-1429.55trans-L-3-hydroxyproline dehydratase [Source:HGNC ... [more]
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
l3hypdh3.704e-7034.49trans-L-3-hydroxyproline dehydratase [Source:ZFIN;... [more]
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
prss166.096e-7234.97serine protease 16 [Source:Xenbase;Acc:XB-GENE-590... [more]
prss162.969e-6234.98serine protease 16 [Source:Xenbase;Acc:XB-GENE-590... [more]
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
L3hypdh8.396e-7035.73L-3-hydroxyproline dehydratase (trans-) [Source:MG... [more]
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P0DKB4|T3HPD_SACKO1.783e-7136.61Trans-L-3-hydroxyproline dehydratase OS=Saccogloss... [more]
sp|Q3SX04|T3HPD_BOVIN1.044e-7035.84Trans-L-3-hydroxyproline dehydratase OS=Bos taurus... [more]
sp|Q66II5|T3HPD_XENTR1.293e-7034.68Trans-L-3-hydroxyproline dehydratase OS=Xenopus tr... [more]
sp|Q9CXA2|T3HPD_MOUSE5.873e-6935.73Trans-L-3-hydroxyproline dehydratase OS=Mus muscul... [more]
sp|Q5RC28|T3HPD_PONAB7.015e-6835.16Trans-L-3-hydroxyproline dehydratase OS=Pongo abel... [more]
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3M6V3675.579e-7336.26Uncharacterized protein OS=Pocillopora damicornis ... [more]
A0A1S3J6Y62.033e-7238.08trans-L-3-hydroxyproline dehydratase-like OS=Lingu... [more]
A0A1S3J6V64.369e-7237.79trans-L-3-hydroxyproline dehydratase OS=Lingula un... [more]
A0A1B1JCG81.218e-7137.24Trans-L-3-hydroxyproline dehydratase-like protein ... [more]
A0A1S3MAE33.075e-7134.34trans-3-hydroxy-L-proline dehydratase isoform X1 O... [more]
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
l3hypdh2.025e-7234.08trans-L-3-hydroxyproline dehydratase [Source:NCBI ... [more]
l3hypdh2.025e-7234.08trans-L-3-hydroxyproline dehydratase [Source:NCBI ... [more]
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4
Match NameE-valueIdentityDescription
EDO307572.282e-7135.99Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO358091.471e-6635.47Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO254849.992e-3633.96Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8... [more]
EDO259647.719e-820.16Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSORLT00000021808.23.899e-6532.61trans-L-3-hydroxyproline dehydratase [Source:NCBI ... [more]
ENSORLT00000041946.12.385e-6134.54trans-L-3-hydroxyproline dehydratase [Source:NCBI ... [more]
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BLAST of Trans-L-3-hydroxyproline dehydratase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000021283.10.000e+099.71SMESG000021283.1[more]
SMESG000021281.16.545e-13552.77SMESG000021281.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30015802 ID=SMED30015802|Name=Trans-L-3-hydroxyproline dehydratase|organism=Schmidtea mediterranea sexual|type=transcript|length=1142bp
CTTATATAAATTCACATCAAAAATGTCATTAAATAATTGACTTTTACAAG
ACAAAATGGAATATAACAAGATCTTGAATGGATATAAGTTAGAAACCTGT
GAAATGCACACTTGTGGGGAGCCCGTGAGAATTCTCGAAAGCACCGAACC
GAAAATAAGATTCCCTGACCACTCGGATATTTTGGTAAAAAAAAAGTTTT
TTTCAGAAAATTTCGATTTTATTAGACAAATGCTAATGCTGGAACCGAGA
GGTCACAAAGATATGTTTGGAGTAATTATGACTGAACCTAATGAAAACAG
TGGATCGGACATAGGGATTTTATTTTTAAATACTATTGGCTACGCATCAA
TGTGTGGACACGCTTCAATTGCAATTGGTCGGTATATGTTAGAGAAGAAT
CTAATAACTCCTGATATTCCAGAAACTACAATAAGAATGGACTGTCTATG
CGGTTTAGTGATATTGTTCGTTGAATGGGATGGAGTGAAAATCGGCAAAA
CTAAATTTCACAGTGTTCCAGCTTTTGTTCTAAATCCAAACTACGAAGTC
TCTATTCCACAGTTTGAATTTCCATTAAAATGTGATATTGTGTATGGAGG
AAACTTTTATGCAATTATATCAACCAAAGATTTAAAAACTAAGTTTACCT
CTTCAAATAAAGAAAAGATTATTGAGAATGGAATTTCGTTGATGAAAACT
CTTAGGAAATCTTTCAGGTTTCCTCAATCCATGATTAATCCAAACCCCTA
TCTGTATGGAGTTTTGATAACCGAAAACCATGAAAATAGTAACACGACAG
ATGTTCTTTGTATTTTCGGAGAAGAGTCTGTTGACAGAAGTCCGTGTGGA
TCTGGTACAACTGCAATTATAGCCCGAGATTATTTTGCACAAAAATTACA
TTTAATGGAAAAGAAAATTACTAGAAACCCATTGCTTGGAGATCATTCAA
ATTTCACAGGGATCCCATTAAAAGAAAACATTTTAATAACTTCGAATTGC
GAACTTAAATGCATTACGGTACAAATTAGTGGCCGAGCATACTTTGCAGG
GAAATCCACTTTTACATACGAAGAAGATGATCATTTTAAGTTTGGCTTTA
ATTTATAATTATAATTGCATTTCAAATATATTTTTGTTTTCG
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protein sequence of SMED30015802-orf-1

>SMED30015802-orf-1 ID=SMED30015802-orf-1|Name=SMED30015802-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=351bp
MEYNKILNGYKLETCEMHTCGEPVRILESTEPKIRFPDHSDILVKKKFFS
ENFDFIRQMLMLEPRGHKDMFGVIMTEPNENSGSDIGILFLNTIGYASMC
GHASIAIGRYMLEKNLITPDIPETTIRMDCLCGLVILFVEWDGVKIGKTK
FHSVPAFVLNPNYEVSIPQFEFPLKCDIVYGGNFYAIISTKDLKTKFTSS
NKEKIIENGISLMKTLRKSFRFPQSMINPNPYLYGVLITENHENSNTTDV
LCIFGEESVDRSPCGSGTTAIIARDYFAQKLHLMEKKITRNPLLGDHSNF
TGIPLKENILITSNCELKCITVQISGRAYFAGKSTFTYEEDDHFKFGFNL
*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0000034epidermis
Vocabulary: INTERPRO
TermDefinition
IPR008794Pro_racemase_fam
Vocabulary: biological process
TermDefinition
GO:0008152metabolic process
Vocabulary: molecular function
TermDefinition
GO:0016829lyase activity
GO:0016836hydro-lyase activity
GO:0050346trans-L-3-hydroxyproline dehydratase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR008794Proline racemase familyPFAMPF05544Pro_racemasecoord: 16..348
e-value: 4.4E-67
score: 226.4
IPR008794Proline racemase familyPIRSFPIRSF029792Pro_racemasecoord: 9..350
e-value: 5.1E-74
score: 246.8
IPR008794Proline racemase familySFLDSFLDS00028Proline_Racemasecoord: 11..350
e-value: 0.0
score: 258.8
IPR008794Proline racemase familyPANTHERPTHR33442FAMILY NOT NAMEDcoord: 9..349
NoneNo IPR availableGENE3DG3DSA:3.10.310.10coord: 15..348
e-value: 4.2E-80
score: 271.3
NoneNo IPR availableGENE3DG3DSA:3.10.310.10coord: 154..334
e-value: 4.2E-80
score: 271.3
NoneNo IPR availablePANTHERPTHR33442:SF1TRANS-3-HYDROXY-L-PROLINE DEHYDRATASEcoord: 9..349
NoneNo IPR availableSUPERFAMILYSSF54506Diaminopimelate epimerase-likecoord: 12..348