PDZ/DHR/GLGF domain protein

Overview
NamePDZ/DHR/GLGF domain protein
Smed IDSMED30015740
Length (bp)1336
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of PDZ/DHR/GLGF domain protein (SMED30015740) t-SNE clustered cells

Violin plots show distribution of expression levels for PDZ/DHR/GLGF domain protein (SMED30015740) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of PDZ/DHR/GLGF domain protein (SMED30015740) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for PDZ/DHR/GLGF domain protein (SMED30015740) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30015740

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
muscle cellSMED30015740SMESG000032390.1 dd_Smed_v4_11753_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30015740SMESG000032390.1 dd_Smed_v6_11753_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Human
Match: PDZD3 (PDZ domain containing 3 [Source:HGNC Symbol;Acc:HGNC:19891])

HSP 1 Score: 66.6254 bits (161), Expect = 3.855e-11
Identity = 51/189 (26.98%), Postives = 82/189 (43.39%), Query Frame = 1 
Query:  625 IDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKAR--------------------SLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHV 1131
            ++  R  +L ++  K FG  L +   G     +  + PG+ AQ  GL+ GD+I+ V+N  V       +V  IRA    V +   AR                       VR ++ H+ K+   FG  +    QG F   +    AA++A +  G +LL++N V V  ++  + T  L  S Q +TL V
Sbjct:  110 LERPRFCLLSKEEGKSFGFHLQQ-ELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGVSVEKFTHNQLTRKLWQSGQQVTLLV 297
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Human
Match: PDZD3 (PDZ domain containing 3 [Source:HGNC Symbol;Acc:HGNC:19891])

HSP 1 Score: 66.6254 bits (161), Expect = 3.939e-11
Identity = 56/207 (27.05%), Postives = 89/207 (43.00%), Query Frame = 1 
Query:  577 NNHNSSETENSISYHP--IDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKAR--------------------SLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHV 1131
            +N   S  E+   Y P  ++  R  +L ++  K FG  L +   G     +  + PG+ AQ  GL+ GD+I+ V+N  V       +V  IRA    V +   AR                       VR ++ H+ K+   FG  +    QG F   +    AA++A +  G +LL++N V V  ++  + T  L  S Q +TL V
Sbjct:   26 DNPVLSLAEDHDPYDPWSLERPRFCLLSKEEGKSFGFHLQQ-ELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGVSVEKFTHNQLTRKLWQSGQQVTLLV 231
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Human
Match: PDZD3 (PDZ domain containing 3 [Source:HGNC Symbol;Acc:HGNC:19891])

HSP 1 Score: 65.855 bits (159), Expect = 7.015e-11
Identity = 51/189 (26.98%), Postives = 82/189 (43.39%), Query Frame = 1 
Query:  625 IDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKAR--------------------SLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHV 1131
            ++  R  +L ++  K FG  L +   G     +  + PG+ AQ  GL+ GD+I+ V+N  V       +V  IRA    V +   AR                       VR ++ H+ K+   FG  +    QG F   +    AA++A +  G +LL++N V V  ++  + T  L  S Q +TL V
Sbjct:   31 LERPRFCLLSKEEGKSFGFHLQQ-ELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGVSVEKFTHNQLTRKLWQSGQQVTLLV 218
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Human
Match: DLG2 (discs large MAGUK scaffold protein 2 [Source:HGNC Symbol;Acc:HGNC:2901])

HSP 1 Score: 57.7658 bits (138), Expect = 6.144e-9
Identity = 44/153 (28.76%), Postives = 75/153 (49.02%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN+++ + L V   T
Sbjct:   45 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPT 197
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Human
Match: DLG2 (discs large MAGUK scaffold protein 2 [Source:HGNC Symbol;Acc:HGNC:2901])

HSP 1 Score: 58.5362 bits (140), Expect = 1.473e-8
Identity = 44/153 (28.76%), Postives = 75/153 (49.02%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRVQ--------GVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN+++ + L V   T
Sbjct:  167 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPT 319
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Celegans
Match: mpz-1 (Multiple PDZ domain protein [Source:UniProtKB/TrEMBL;Acc:G1K0W2])

HSP 1 Score: 49.2914 bits (116), Expect = 5.884e-6
Identity = 43/155 (27.74%), Postives = 71/155 (45.81%), Query Frame = 1 
Query:  739 GSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVF-YK----ARSLLVRTKVVHL------KKENNRFGLRLIRR--VQGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQT--LTLHVYDATFAAN 1155
            G+ A    LK GDQ++ V+   +  ++ +  + Y+R     VR+  Y+      SLL  T++ ++      KK     G+ ++ R    GV+V  ++    A+    L  GDQ+L++N  DV    QE    +LK  T    L L  +  T  AN
Sbjct: 2094 GAAAHDGRLKPGDQVLEVNGTSLRGVTHDQSIAYLRRTPPKVRLLIYRDVNLQLSLLDPTQIYNIFEIDLVKKTGRGLGISIVGRKNEPGVYVSEIVKGGLAESDGRLMTGDQILEVNGKDVRGCMQEDVAAMLKTITGKVHLKLGRWKITETAN 2248
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Celegans
Match: mpz-1 (Multiple PDZ domain protein [Source:UniProtKB/TrEMBL;Acc:G1K0W2])

HSP 1 Score: 48.9062 bits (115), Expect = 6.329e-6
Identity = 43/155 (27.74%), Postives = 71/155 (45.81%), Query Frame = 1 
Query:  739 GSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVF-YK----ARSLLVRTKVVHL------KKENNRFGLRLIRR--VQGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQT--LTLHVYDATFAAN 1155
            G+ A    LK GDQ++ V+   +  ++ +  + Y+R     VR+  Y+      SLL  T++ ++      KK     G+ ++ R    GV+V  ++    A+    L  GDQ+L++N  DV    QE    +LK  T    L L  +  T  AN
Sbjct:  583 GAAAHDGRLKPGDQVLEVNGTSLRGVTHDQSIAYLRRTPPKVRLLIYRDVNLQLSLLDPTQIYNIFEIDLVKKTGRGLGISIVGRKNEPGVYVSEIVKGGLAESDGRLMTGDQILEVNGKDVRGCMQEDVAAMLKTITGKVHLKLGRWKITETAN 737
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Celegans
Match: mpz-1 (Multiple PDZ domain protein [Source:UniProtKB/TrEMBL;Acc:G1K0W2])

HSP 1 Score: 49.2914 bits (116), Expect = 6.622e-6
Identity = 43/155 (27.74%), Postives = 71/155 (45.81%), Query Frame = 1 
Query:  739 GSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVF-YK----ARSLLVRTKVVHL------KKENNRFGLRLIRR--VQGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQT--LTLHVYDATFAAN 1155
            G+ A    LK GDQ++ V+   +  ++ +  + Y+R     VR+  Y+      SLL  T++ ++      KK     G+ ++ R    GV+V  ++    A+    L  GDQ+L++N  DV    QE    +LK  T    L L  +  T  AN
Sbjct: 1787 GAAAHDGRLKPGDQVLEVNGTSLRGVTHDQSIAYLRRTPPKVRLLIYRDVNLQLSLLDPTQIYNIFEIDLVKKTGRGLGISIVGRKNEPGVYVSEIVKGGLAESDGRLMTGDQILEVNGKDVRGCMQEDVAAMLKTITGKVHLKLGRWKITETAN 1941
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Celegans
Match: mpz-1 (Multiple PDZ domain protein [Source:UniProtKB/TrEMBL;Acc:G1K0W2])

HSP 1 Score: 49.2914 bits (116), Expect = 6.800e-6
Identity = 43/155 (27.74%), Postives = 71/155 (45.81%), Query Frame = 1 
Query:  739 GSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVF-YK----ARSLLVRTKVVHL------KKENNRFGLRLIRR--VQGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQT--LTLHVYDATFAAN 1155
            G+ A    LK GDQ++ V+   +  ++ +  + Y+R     VR+  Y+      SLL  T++ ++      KK     G+ ++ R    GV+V  ++    A+    L  GDQ+L++N  DV    QE    +LK  T    L L  +  T  AN
Sbjct: 1805 GAAAHDGRLKPGDQVLEVNGTSLRGVTHDQSIAYLRRTPPKVRLLIYRDVNLQLSLLDPTQIYNIFEIDLVKKTGRGLGISIVGRKNEPGVYVSEIVKGGLAESDGRLMTGDQILEVNGKDVRGCMQEDVAAMLKTITGKVHLKLGRWKITETAN 1959
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Celegans
Match: mpz-1 (Multiple PDZ domain protein [Source:UniProtKB/TrEMBL;Acc:G1K0W2])

HSP 1 Score: 48.9062 bits (115), Expect = 7.049e-6
Identity = 43/155 (27.74%), Postives = 71/155 (45.81%), Query Frame = 1 
Query:  739 GSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVF-YK----ARSLLVRTKVVHL------KKENNRFGLRLIRR--VQGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQT--LTLHVYDATFAAN 1155
            G+ A    LK GDQ++ V+   +  ++ +  + Y+R     VR+  Y+      SLL  T++ ++      KK     G+ ++ R    GV+V  ++    A+    L  GDQ+L++N  DV    QE    +LK  T    L L  +  T  AN
Sbjct: 1012 GAAAHDGRLKPGDQVLEVNGTSLRGVTHDQSIAYLRRTPPKVRLLIYRDVNLQLSLLDPTQIYNIFEIDLVKKTGRGLGISIVGRKNEPGVYVSEIVKGGLAESDGRLMTGDQILEVNGKDVRGCMQEDVAAMLKTITGKVHLKLGRWKITETAN 1166
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0112812)

HSP 1 Score: 53.1434 bits (126), Expect = 4.617e-7
Identity = 24/55 (43.64%), Postives = 37/55 (67.27%), Query Frame = 1 
Query:  964 QGVFVDFVIPDSAAD-KADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTL 1125
            QG++V F++    AD  ++LK GDQLL +NNV+++H + E+A   LK S   +TL
Sbjct:  468 QGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTL 522
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0073489)

HSP 1 Score: 52.7582 bits (125), Expect = 4.864e-7
Identity = 26/77 (33.77%), Postives = 45/77 (58.44%), Query Frame = 1 
Query:  904 KVVHLKKENNRFGLRLI--RRVQGVFVDFVIPDSAAD-KADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTL 1125
            + + ++K     G  ++     QG++V F++    AD  ++LK GDQLL +NNV+++H + E+A   LK S   +TL
Sbjct:  485 RTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTL 561
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0308089)

HSP 1 Score: 52.7582 bits (125), Expect = 4.864e-7
Identity = 26/77 (33.77%), Postives = 45/77 (58.44%), Query Frame = 1 
Query:  904 KVVHLKKENNRFGLRLI--RRVQGVFVDFVIPDSAAD-KADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTL 1125
            + + ++K     G  ++     QG++V F++    AD  ++LK GDQLL +NNV+++H + E+A   LK S   +TL
Sbjct:  485 RTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTL 561
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0333262)

HSP 1 Score: 52.7582 bits (125), Expect = 4.866e-7
Identity = 24/55 (43.64%), Postives = 37/55 (67.27%), Query Frame = 1 
Query:  964 QGVFVDFVIPDSAAD-KADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTL 1125
            QG++V F++    AD  ++LK GDQLL +NNV+++H + E+A   LK S   +TL
Sbjct:  515 QGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTL 569
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0073486)

HSP 1 Score: 52.7582 bits (125), Expect = 4.898e-7
Identity = 26/77 (33.77%), Postives = 45/77 (58.44%), Query Frame = 1 
Query:  904 KVVHLKKENNRFGLRLI--RRVQGVFVDFVIPDSAAD-KADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTL 1125
            + + ++K     G  ++     QG++V F++    AD  ++LK GDQLL +NNV+++H + E+A   LK S   +TL
Sbjct:  493 RTITIQKGPQGLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTL 569
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Zebrafish
Match: dlg2 (discs, large homolog 2 (Drosophila) [Source:NCBI gene;Acc:497638])

HSP 1 Score: 58.5362 bits (140), Expect = 1.001e-8
Identity = 57/215 (26.51%), Postives = 97/215 (45.12%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPN-SPNRSRYNELKNH 1326
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++A    VR++ + R  ++ T   + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T      +     +   +I++  S ++      S  +    E+  SLP  SP   RY+ L  H
Sbjct:  166 FITKIIPGGAAAEDGRLRVNDCILRVNESDVSEVSHSKAVEALKAAGSIVRLYVRRRRPMLETVTEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTSDVVYLKVGKPT-----SVYLSDPYGPPDITHSFSPAMENHI-SSPGNNGTLEYKSSLPPISPG--RYSPLPKH 372
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Zebrafish
Match: dlg4b (pep chromosome:GRCz11:23:44307996:44332790:1 gene:ENSDARG00000039385.6 transcript:ENSDART00000042430.7 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:dlg4b)

HSP 1 Score: 56.225 bits (134), Expect = 4.270e-8
Identity = 23/55 (41.82%), Postives = 39/55 (70.91%), Query Frame = 1 
Query:  964 QGVFVDFVIPDSAAD-KADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTL 1125
            +G+F+ F++   AAD   +L++GDQ+L +N VD+ H + E+A   LKN+ QT+T+
Sbjct:   66 EGIFISFILAGGAADLSGELRKGDQILSVNGVDLRHATHEQAAAALKNAGQTVTI 120
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Zebrafish
Match: sdcbp (syndecan binding protein (syntenin) [Source:ZFIN;Acc:ZDB-GENE-081104-57])

HSP 1 Score: 53.1434 bits (126), Expect = 2.598e-7
Identity = 32/79 (40.51%), Postives = 46/79 (58.23%), Query Frame = 1 
Query:  904 KVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNS-TQTLTLHVYD 1137
            +VV  K  + + GLRL     GVFV  V  ++AA  A L+ GDQ+L+IN    + W+ + A  +LKNS  + +TL V D
Sbjct:  123 EVVLCKDMDGKIGLRLKAIDNGVFVQLVQANTAAALAGLRFGDQILEINGKSCAGWNSDYAHKVLKNSNPERITLAVRD 201
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Zebrafish
Match: pdzd3a (PDZ domain containing 3a [Source:ZFIN;Acc:ZDB-GENE-080430-1])

HSP 1 Score: 52.373 bits (124), Expect = 6.854e-7
Identity = 51/199 (25.63%), Postives = 87/199 (43.72%), Query Frame = 1 
Query:  619 HPIDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLV------------------DYIRAKKDSVRVFYKARSL----LVRTKVVHLKKENN-RFGLRL--IRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDA 1140
            HP    R  VL R+  + FG  L R +   +   +  + P S A+ +GL++GD ++ V+  +V      T+V                  DY  A  +   +   ARS       R ++ H+ KE     GL +  I   +G +    + D  A++A ++ GD+L+ IN V +S  S      ++K   + LT+ V D+
Sbjct:   41 HP----RLCVLRREEGQGFGFYLSRDAGRCRGHVVRQVEPWSSAERAGLRIGDHVLEVNEDFVDDKEHSTVVLKVQASGLKLYLLVLSAQDYEFAVSEGRDLLSVARSYRPEGCSRPRLCHITKEPGCGLGLSIIPIEGARGRYRLNPVTDGPAERAGIQNGDRLIWINGVSISVISYAALAKMVKKCEKHLTVLVIDS 235
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Zebrafish
Match: pdzd11 (PDZ domain containing 11 [Source:NCBI gene;Acc:405893])

HSP 1 Score: 48.1358 bits (113), Expect = 2.387e-6
Identity = 21/51 (41.18%), Postives = 32/51 (62.75%), Query Frame = 1 
Query:  967 GVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTL 1119
            G+F+  V+PDS A +A L+EGDQ+L +N VD       +A  +LK + + L
Sbjct:   73 GIFISKVVPDSDAHRAGLQEGDQVLSVNEVDFQDIEHSRAVEILKTAREIL 123
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Xenopus
Match: hjv (hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB-GENE-922976])

HSP 1 Score: 56.9954 bits (136), Expect = 4.430e-8
Identity = 44/153 (28.76%), Postives = 74/153 (48.37%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T
Sbjct:  142 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPT 294
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Xenopus
Match: hjv (hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB-GENE-922976])

HSP 1 Score: 56.9954 bits (136), Expect = 4.690e-8
Identity = 67/259 (25.87%), Postives = 117/259 (45.17%), Query Frame = 1 
Query:  601 ENSISYHPID-EIRDVVLVRDSSK-RFGIK--LDRTSFGEQIT-YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSL-PNSPNRSRYNELKNH 1326
            EN+I+   I+ E  ++ L R +S   F I   +D    G+    +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T      +     +   +I++  S  + +    S ++    E+   L P SP   RY+ +  H
Sbjct:   91 ENAINGTEIEYEFEEITLERGNSGLGFSIAGGIDNPHVGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPT-----TIYMTDPYGPPDITHSYSPPLESHILSSANNGT-LEYKSPLAPISPG--RYSPIPKH 341
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Xenopus
Match: hjv (hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB-GENE-922976])

HSP 1 Score: 56.6102 bits (135), Expect = 5.545e-8
Identity = 44/153 (28.76%), Postives = 74/153 (48.37%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T
Sbjct:  118 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPT 270
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Xenopus
Match: hjv (hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB-GENE-922976])

HSP 1 Score: 56.6102 bits (135), Expect = 5.968e-8
Identity = 44/153 (28.76%), Postives = 74/153 (48.37%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T
Sbjct:  118 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPT 270
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Xenopus
Match: hjv (hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB-GENE-922976])

HSP 1 Score: 56.6102 bits (135), Expect = 6.145e-8
Identity = 55/215 (25.58%), Postives = 97/215 (45.12%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSL-PNSPNRSRYNELKNH 1326
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T      +     +   +I++  S  + +    S ++    E+   L P SP   RY+ +  H
Sbjct:  123 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPT-----TIYMTDPYGPPDITHSYSPPLESHILSSANNGT-LEYKSPLAPISPG--RYSPIPKH 329
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Mouse
Match: Pdzd3 (PDZ domain containing 3 [Source:MGI Symbol;Acc:MGI:2429554])

HSP 1 Score: 59.6918 bits (143), Expect = 3.673e-9
Identity = 49/185 (26.49%), Postives = 80/185 (43.24%), Query Frame = 1 
Query:  637 RDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKK-------------DSVRVFYKARSLL-------VRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHV 1131
            R  +L ++  K FG  L +   G+    +  + PG+ AQ  GL+ GD+I+ V+N  V       +V YIRA               D  RV   + + L       VR ++ H+ K+   FG  +    +G F   +    AA++A +  G +LL++N   V   +  +    L  S   +TL V
Sbjct:   48 RFCLLSKEEEKTFGFHLQQ-HLGKADHVVCRVDPGTSAQRQGLREGDRILAVNNNIVAHEDHAVVVRYIRASGPRVLLTVLAQHVHDVARVLQGSDAFLCPTLPSGVRPRLCHVVKDEGGFGFSVTHGSRGPFWLVLSAGGAAERAGVPPGARLLEVNGASVEKLTYNQLNRKLWQSGDQVTLLV 231
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Mouse
Match: Dlg2 (discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351])

HSP 1 Score: 56.9954 bits (136), Expect = 4.258e-8
Identity = 44/153 (28.76%), Postives = 74/153 (48.37%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T
Sbjct:  270 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPT 422
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Mouse
Match: Dlg2 (discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351])

HSP 1 Score: 56.6102 bits (135), Expect = 4.427e-8
Identity = 44/153 (28.76%), Postives = 74/153 (48.37%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T
Sbjct:  163 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPT 315
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Mouse
Match: Dlg2 (discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351])

HSP 1 Score: 56.6102 bits (135), Expect = 5.102e-8
Identity = 44/153 (28.76%), Postives = 74/153 (48.37%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T
Sbjct:  163 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPT 315
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Mouse
Match: Dlg2 (discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351])

HSP 1 Score: 56.6102 bits (135), Expect = 5.350e-8
Identity = 44/153 (28.76%), Postives = 74/153 (48.37%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T
Sbjct:  163 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPT 315
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. UniProt/SwissProt
Match: sp|Q86UT5|NHRF4_HUMAN (Na(+)/H(+) exchange regulatory cofactor NHE-RF4 OS=Homo sapiens OX=9606 GN=PDZD3 PE=1 SV=2)

HSP 1 Score: 66.6254 bits (161), Expect = 1.851e-10
Identity = 51/189 (26.98%), Postives = 82/189 (43.39%), Query Frame = 1 
Query:  625 IDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKAR--------------------SLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHV 1131
            ++  R  +L ++  K FG  L +   G     +  + PG+ AQ  GL+ GD+I+ V+N  V       +V  IRA    V +   AR                       VR ++ H+ K+   FG  +    QG F   +    AA++A +  G +LL++N V V  ++  + T  L  S Q +TL V
Sbjct:  110 LERPRFCLLSKEEGKSFGFHLQQ-ELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGVSVEKFTHNQLTRKLWQSGQQVTLLV 297
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. UniProt/SwissProt
Match: sp|Q99MJ6|NHRF4_MOUSE (Na(+)/H(+) exchange regulatory cofactor NHE-RF4 OS=Mus musculus OX=10090 GN=Pdzd3 PE=1 SV=1)

HSP 1 Score: 59.6918 bits (143), Expect = 2.615e-8
Identity = 49/185 (26.49%), Postives = 80/185 (43.24%), Query Frame = 1 
Query:  637 RDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKK-------------DSVRVFYKARSLL-------VRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHV 1131
            R  +L ++  K FG  L +   G+    +  + PG+ AQ  GL+ GD+I+ V+N  V       +V YIRA               D  RV   + + L       VR ++ H+ K+   FG  +    +G F   +    AA++A +  G +LL++N   V   +  +    L  S   +TL V
Sbjct:   48 RFCLLSKEEEKTFGFHLQQ-HLGKADHVVCRVDPGTSAQRQGLREGDRILAVNNNIVAHEDHAVVVRYIRASGPRVLLTVLAQHVHDVARVLQGSDAFLCPTLPSGVRPRLCHVVKDEGGFGFSVTHGSRGPFWLVLSAGGAAERAGVPPGARLLEVNGASVEKLTYNQLNRKLWQSGDQVTLLV 231
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. UniProt/SwissProt
Match: sp|Q6R005|DLG4_DANRE (Disks large homolog 4 OS=Danio rerio OX=7955 GN=dlg4 PE=2 SV=1)

HSP 1 Score: 58.9214 bits (141), Expect = 6.240e-8
Identity = 48/196 (24.49%), Postives = 80/196 (40.82%), Query Frame = 1 
Query:  703 GEQITYIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLV-------------------------------------------DYIRAKKDSVRVFYKA--RSLLV--------RTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAAD-KADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTL 1125
            G+   Y+  I+ G  A   G L++GD+I+ V+N Y+ ++  E  V                                           DY +A   S    Y    + L +        R  V+H       F +      +G+F+ F++   AAD   +L++GDQ+L +N VD+ H + E+A   LKN+ QT+T+
Sbjct:  273 GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNNMYLEEVMHEDAVAALKNTGDVVFLRVAKTLHQHHHQDAYNPPDITSSYSPHMDMSDYPQALSPSSPRRYSPIPKGLFLDDDISREPRRVVIHRGSTGLGFNIVGGEDGEGIFISFILAGGAADLSGELRKGDQILSVNGVDLRHATHEQAAAALKNAGQTVTI 468
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. UniProt/SwissProt
Match: sp|Q5PYH7|DLG2_DANRE (Disks large homolog 2 OS=Danio rerio OX=7955 GN=dlg2 PE=2 SV=1)

HSP 1 Score: 58.9214 bits (141), Expect = 6.913e-8
Identity = 57/215 (26.51%), Postives = 97/215 (45.12%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPN-SPNRSRYNELKNH 1326
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++A    VR++ + R  ++ T   + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN++  + L V   T      +     +   +I++  S ++      S  +    E+  SLP  SP   RY+ L  H
Sbjct:  185 FITKIIPGGAAAEDGRLRVNDCILRVNESDVSEVSHSKAVEALKAAGSIVRLYVRRRRPMLETVTEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTSDVVYLKVGKPT-----SVYLSDPYGPPDITHSFSPAMENHI-SSPGNNGTLEYKSSLPPISPG--RYSPLPKH 391
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. UniProt/SwissProt
Match: sp|Q15700|DLG2_HUMAN (Disks large homolog 2 OS=Homo sapiens OX=9606 GN=DLG2 PE=1 SV=3)

HSP 1 Score: 57.3806 bits (137), Expect = 1.938e-7
Identity = 44/153 (28.76%), Postives = 75/153 (49.02%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN+++ + L V   T
Sbjct:  128 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPT 280
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. TrEMBL
Match: A0A4E0RLE5 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_000933 PE=4 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 1.288e-30
Identity = 72/214 (33.64%), Postives = 122/214 (57.01%), Query Frame = 1 
Query:  571 VCNNHNSS------ETENSISYHPIDEIRDVVLVR-DSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKN--STQTLTLHVYDATFAANDCLNQKSIFC 1185
            VC  H S       E++    ++ I EIR+ +L+R +   RFG++++    G    Y+  +L  S A  +GLKVGD++++++ F +  +S  T+++ +R+   ++ V Y+ R LL R   + +KK + R G+RL R  +G+FVD V+P SAA +A +KEGD+LL +N   VS WSQ+  + +L+   S Q + L++       +   N K I C
Sbjct:  401 VCKEHGSGFHVPHCESQELCHHYRIPEIRETILIRPEGMHRFGMRIESIGGG---VYLTTVLKNSPASAAGLKVGDELIQLNGFQLTSLSTPTIMELVRSTPQALHVTYRPRMLLARCHEIQIKKLDGRVGIRLKRLPEGMFVDVVLPFSAASQAGIKEGDELLMVNGQPVSSWSQDGVSQMLREIPSDQIVRLYIKQLVPLRDLITNPKKILC 611
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. TrEMBL
Match: A0A5K4FF09 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 1.361e-30
Identity = 61/161 (37.89%), Postives = 113/161 (70.19%), Query Frame = 1 
Query:  622 PIDEIRDVVLVR-DSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLK 1101
            P  EIR++ + R ++ +RFG+++++  FG+  TY+  +LPGS+A  +GLKVGD+I+ ++   +  IS+ ++   +R+ +  +++ Y+ R++L + + + +KK N R G+RL R  +G++VD V+P+SAA +A +KEGD+L+ +NN  V+ W+QE A+ LL+
Sbjct:  418 PFQEIREISVTRSEAGQRFGMRIEK--FGKG-TYLTTVLPGSLASQAGLKVGDEILHLNGISLQSISINSINQLVRSTRQ-LKIAYRPRTMLAKIRFILVKKINGRVGIRLKRMAEGLYVDVVLPNSAAYEAGIKEGDELICVNNQIVTSWTQEAASKLLR 574
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. TrEMBL
Match: A0A4Z2DF97 (Protein scribble OS=Schistosoma japonicum OX=6182 GN=EWB00_001647 PE=4 SV=1)

HSP 1 Score: 133.265 bits (334), Expect = 8.790e-30
Identity = 60/161 (37.27%), Postives = 111/161 (68.94%), Query Frame = 1 
Query:  622 PIDEIRDVVLVR-DSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLK 1101
            P  E+R++ L R +  +RFG+++++   G   TY+  +LPGS+A  +GLK+GD+I++V+   +  IS+ ++   +R+ +  +++ Y+ R++L + + + +KK + R G+RL R  QG++VD V+P+SAA +A +KEGD+L+ +NN  V+ W+QE A+ LL+
Sbjct:  423 PFQEVREICLTRPEVGQRFGMRIEKVGKG---TYLTTVLPGSVASQAGLKIGDEILQVNGISIQSISINSINQLVRSTRQ-LKIAYRPRTILTKIRFITVKKIDGRVGIRLKRTAQGLYVDVVLPNSAASEAGIKEGDELICVNNQIVTSWTQEAASKLLR 579
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. TrEMBL
Match: A0A183AN87 (Uncharacterized protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS8422 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 1.107e-26
Identity = 63/157 (40.13%), Postives = 94/157 (59.87%), Query Frame = 1 
Query:  634 IRDVVLVRD-SSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLK 1101
            +R+V L R    +RFG+KLDRT   E+ITYI MILP S A  +GL+VGDQ++RV+   V Q+ ++ L++ IR+   S+RV Y++R     TK + ++K+  + G+RL     G+ VD V+  S A    L  G +LL +N   V  W Q  A + L+
Sbjct:  309 MREVTLQRRYPQQRFGMKLDRTESPEKITYIAMILPESPASQAGLRVGDQVLRVNQTDVQQMELDDLLNRIRSADQSLRVVYQSRPTCGLTKTMIIRKQCGKLGIRLRTEPSGLVVDVVLSGSPAASVGLLAGQRLLGLNGQHVGGWDQRTAMNWLR 465
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. TrEMBL
Match: G7YEW7 (Syntenin-2 OS=Clonorchis sinensis OX=79923 GN=CLF_106264 PE=4 SV=1)

HSP 1 Score: 119.783 bits (299), Expect = 1.299e-26
Identity = 60/162 (37.04%), Postives = 101/162 (62.35%), Query Frame = 1 
Query:  625 IDEIRDVVLVR-DSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSV-RVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKN 1104
            + E+R+V LVR +   RFG++++    G    Y+  +L  S A  +GLKVGD+++ +D   V  +S     + +R+    V R+ Y+ R+ +   + V +KK + R G+RL RR +G+FVD V+P SAA  A ++EGD+L+K+NN  ++ WSQ+ A+ LL++
Sbjct:   30 LPEVREVTLVRRNVGHRFGMRIESLGCG---IYVTTVLRNSPAATAGLKVGDELLTIDGEPVSHMSTHGATERVRSSASEVLRITYRPRTPVTCIREVTVKKIDGRVGIRLKRRKEGLFVDVVLPCSAASNAGIREGDELIKVNNQPINGWSQDAASQLLRD 188
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Cavefish
Match: dlg2 (discs, large homolog 2 (Drosophila) [Source:NCBI gene;Acc:497638])

HSP 1 Score: 61.2326 bits (147), Expect = 1.540e-9
Identity = 58/215 (26.98%), Postives = 98/215 (45.58%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRVQ--------GVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPN-SPNRSRYNELKNH 1326
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN+   + L V   T      +     +   +I++  S +++     S  +    E+  SLP  SP  SRY+ L  H
Sbjct:  230 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKVAGSIVRLYVRRRRPMLETVVEIKLVKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTADVVYLKVGKPT-----SVYLSDPYGPPDITHSFSPAMDNHI-SSAGNNGTLEYKSSLPPISP--SRYSPLPRH 436
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Cavefish
Match: dlg2 (discs, large homolog 2 (Drosophila) [Source:NCBI gene;Acc:497638])

HSP 1 Score: 60.8474 bits (146), Expect = 1.866e-9
Identity = 58/215 (26.98%), Postives = 98/215 (45.58%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRVQ--------GVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPN-SPNRSRYNELKNH 1326
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN+   + L V   T      +     +   +I++  S +++     S  +    E+  SLP  SP  SRY+ L  H
Sbjct:  233 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKVAGSIVRLYVRRRRPMLETVVEIKLVKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTADVVYLKVGKPT-----SVYLSDPYGPPDITHSFSPAMDNHI-SSAGNNGTLEYKSSLPPISP--SRYSPLPRH 439
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Cavefish
Match: dlg2 (discs, large homolog 2 (Drosophila) [Source:NCBI gene;Acc:497638])

HSP 1 Score: 60.4622 bits (145), Expect = 2.122e-9
Identity = 58/215 (26.98%), Postives = 98/215 (45.58%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRVQ--------GVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPN-SPNRSRYNELKNH 1326
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN+   + L V   T      +     +   +I++  S +++     S  +    E+  SLP  SP  SRY+ L  H
Sbjct:  155 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKVAGSIVRLYVRRRRPMLETVVEIKLVKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTADVVYLKVGKPT-----SVYLSDPYGPPDITHSFSPAMDNHI-SSAGNNGTLEYKSSLPPISP--SRYSPLPRH 361
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Cavefish
Match: dlg2 (discs, large homolog 2 (Drosophila) [Source:NCBI gene;Acc:497638])

HSP 1 Score: 60.4622 bits (145), Expect = 2.195e-9
Identity = 58/215 (26.98%), Postives = 98/215 (45.58%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRVQ--------GVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPN-SPNRSRYNELKNH 1326
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN+   + L V   T      +     +   +I++  S +++     S  +    E+  SLP  SP  SRY+ L  H
Sbjct:  238 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKVAGSIVRLYVRRRRPMLETVVEIKLVKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTADVVYLKVGKPT-----SVYLSDPYGPPDITHSFSPAMDNHI-SSAGNNGTLEYKSSLPPISP--SRYSPLPRH 444
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Cavefish
Match: dlg2 (discs, large homolog 2 (Drosophila) [Source:NCBI gene;Acc:497638])

HSP 1 Score: 59.3066 bits (142), Expect = 5.239e-9
Identity = 58/215 (26.98%), Postives = 98/215 (45.58%), Query Frame = 1 
Query:  718 YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRVQ--------GVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPN-SPNRSRYNELKNH 1326
            +I  I+PG  A   G L+V D I+RV+   V ++S    V+ ++     VR++ + R  ++ T V + L K     G  +   V          ++V  +I   AA K   L+ GD+LL +NN  +   + E+A  +LKN+   + L V   T      +     +   +I++  S +++     S  +    E+  SLP  SP  SRY+ L  H
Sbjct:  163 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKVAGSIVRLYVRRRRPMLETVVEIKLVKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTADVVYLKVGKPT-----SVYLSDPYGPPDITHSFSPAMDNHI-SSAGNNGTLEYKSSLPPISP--SRYSPLPRH 369
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Sea Lamprey
Match: SDCBP (syndecan binding protein [Source:HGNC Symbol;Acc:HGNC:10662])

HSP 1 Score: 51.9878 bits (123), Expect = 7.587e-8
Identity = 28/82 (34.15%), Postives = 46/82 (56.10%), Query Frame = 1 
Query:  904 KVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNST-QTLTLHVYDATF 1146
            +V+  K ++ + GLRL    +G+FV  V   S A  A L+ GDQ+L+IN  + + W  +KA  +LK +  + + + V D  F
Sbjct:   74 EVILCKDQDGKLGLRLKAVDKGIFVQLVQGGSPASLAGLRFGDQVLQINGENCAAWDTDKAHKVLKKAAPERIVMAVRDRPF 155
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004677.1 (pep scaffold:Pmarinus_7.0:GL479538:28591:32639:-1 gene:ENSPMAG00000004260.1 transcript:ENSPMAT00000004677.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.447 bits (119), Expect = 9.794e-8
Identity = 42/143 (29.37%), Postives = 68/143 (47.55%), Query Frame = 1 
Query:  739 GSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVF-------YKA--RSLLVRTKVVHLKKENNRFGLRLI--RRVQGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHV 1131
            G+ A+   L  GDQI++V+   +   + E  ++ +RA    VR++       Y+    S L    V  LKK     GL ++  +   GVFV  V+   AA+    L +GDQ+L ++  DV   SQE    +LK +   + + V
Sbjct:   13 GAAAKDGRLWAGDQILKVNGTDLRSATHEDAINALRASPQLVRLYVYRDEARYRGDDESALHVFTVELLKKAGRGLGLSIVGKKSGNGVFVSEVVHGGAAEADGRLTQGDQILSVDGEDVRSASQETVAAILKCAQGVVKMEV 155
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Sea Lamprey
Match: lin7a (lin-7 homolog A (C. elegans) [Source:ZFIN;Acc:ZDB-GENE-040426-1665])

HSP 1 Score: 46.9802 bits (110), Expect = 1.710e-6
Identity = 27/78 (34.62%), Postives = 40/78 (51.28%), Query Frame = 1 
Query:  904 KVVHLKKENNRFGLRLIRRVQ---GVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTL 1125
            +VV L K +   G  ++   +    +++  +IP   AD+   LK GDQLL +N V V     EKA  LLK +  T+ L
Sbjct:   79 RVVELPKTDEGLGFNIMGGKEQNSPIYISRIIPGGVADRQGGLKRGDQLLSVNGVSVEGEHHEKAVELLKQAQGTVKL 156
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001894.1 (pep scaffold:Pmarinus_7.0:GL482309:11063:22203:-1 gene:ENSPMAG00000001715.1 transcript:ENSPMAT00000001894.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 46.595 bits (109), Expect = 9.681e-6
Identity = 47/189 (24.87%), Postives = 84/189 (44.44%), Query Frame = 1 
Query:  622 PIDEIRDVVLVRDSSKRFGIKLD---RTSFGEQITYIVMILPGSIA--QMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTK------VVHLKKENNRFGLRLI---RRVQGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            P   I  V L +  S   GI +    R SFGE +  I  I  GS+A  ++  L+ GD+++ +D  ++   SM      +R  +D V++  +        +       V LK+     G+ +      +  + +  + P   A++   +  GDQ+L INNV +      +A  LL+ S++T+ L +   T
Sbjct:    9 PSSGIFHVKLPKKRSVELGITISSPSRRSFGEPLV-ITDIRKGSVAHRRIGTLEPGDRLLAIDQVHLENASMADAAQVLRQCEDLVKLKIRKDDDGANDEGGAISYTVELKRYGGPLGITISGTEEPLDPITISGLTPSGLAERTGAIHVGDQILAINNVSLKAKGLTEAIQLLQRSSETVALKIKKPT 196
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Nematostella
Match: EDO42095 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2D9])

HSP 1 Score: 48.9062 bits (115), Expect = 1.458e-6
Identity = 31/92 (33.70%), Postives = 48/92 (52.17%), Query Frame = 1 
Query:  904 KVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKN-STQTLTLHVYDATFAANDCLNQKS 1176
            +V+  K    + GLR+    +G+FV FV  DS A    L+ GDQ+L+I+  +++ +  +KA   LKN S Q +   V D  F     L + S
Sbjct:   76 EVILCKDNEGKLGLRVRAVNKGIFVAFVHKDSPAALGGLRFGDQILQIDGENMAGFDTDKAMKRLKNASPQRVVFAVRDRPFERTIVLQKDS 167
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Nematostella
Match: EDO48372 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJG2])

HSP 1 Score: 48.9062 bits (115), Expect = 4.668e-6
Identity = 42/143 (29.37%), Postives = 72/143 (50.35%), Query Frame = 1 
Query:  673 FGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLK 1101
            FG K+     G+    I+ +   SIA+ +GL+ GDQI+ ++   V  ++ + +V   R    S RV   A +++ R +   L++   RF    +R    VFV  V P S A    ++ GD +LK+N V V H + E+   +++
Sbjct:   12 FGFKIG----GKAPVVIISVQDNSIAERAGLQAGDQILELNGENVQALTKDQIVLLARR---STRV-PPALAVISRIRTFDLRRRRGRF-GFTVRGSGPVFVHNVEPKSPAFTVGMRTGDLVLKVNGVSVRHANAEQVQQVVE 145
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Medaka
Match: dlg2 (disks large homolog 2 [Source:NCBI gene;Acc:101168565])

HSP 1 Score: 53.9138 bits (128), Expect = 2.875e-7
Identity = 49/164 (29.88%), Postives = 73/164 (44.51%), Query Frame = 1 
Query:  688 DRTSFGEQIT-YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            D   FGE    YI  I+PG  A   G LKV D I+RV++  V  +S    V+ ++     V ++ + R     T V + + K     G  +   V          +F+  +I   AA K   L  GD+LL +NN  V   S E A  +LK+++  + L V   T
Sbjct:  114 DNPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRRRRPAPETVVEIKITKGPKGLGFSIAGGVGNQHLPGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPT 277
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Medaka
Match: dlg2 (disks large homolog 2 [Source:NCBI gene;Acc:101168565])

HSP 1 Score: 53.5286 bits (127), Expect = 3.062e-7
Identity = 49/164 (29.88%), Postives = 73/164 (44.51%), Query Frame = 1 
Query:  688 DRTSFGEQIT-YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            D   FGE    YI  I+PG  A   G LKV D I+RV++  V  +S    V+ ++     V ++ + R     T V + + K     G  +   V          +F+  +I   AA K   L  GD+LL +NN  V   S E A  +LK+++  + L V   T
Sbjct:  114 DNPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRRRRPAPETVVEIKITKGPKGLGFSIAGGVGNQHLPGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPT 277
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Medaka
Match: dlg2 (disks large homolog 2 [Source:NCBI gene;Acc:101168565])

HSP 1 Score: 53.5286 bits (127), Expect = 3.548e-7
Identity = 49/164 (29.88%), Postives = 73/164 (44.51%), Query Frame = 1 
Query:  688 DRTSFGEQIT-YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            D   FGE    YI  I+PG  A   G LKV D I+RV++  V  +S    V+ ++     V ++ + R     T V + + K     G  +   V          +F+  +I   AA K   L  GD+LL +NN  V   S E A  +LK+++  + L V   T
Sbjct:   96 DNPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRRRRPAPETVVEIKITKGPKGLGFSIAGGVGNQHLPGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPT 259
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Medaka
Match: grid2ipa (delphilin [Source:NCBI gene;Acc:101160910])

HSP 1 Score: 53.5286 bits (127), Expect = 3.786e-7
Identity = 32/79 (40.51%), Postives = 44/79 (55.70%), Query Frame = 1 
Query:  904 KVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDA 1140
            + V + K N  FG  L R    V++D VIP S ADKA LK GD++L +N +D+   S EK   +L+ S    TL V + 
Sbjct:  104 RTVRVCKGNMSFGFTL-RGHAPVWIDSVIPGSPADKAGLKPGDRILFLNGLDMRTSSHEKVVSMLQGSGAMPTLVVEEG 181
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Medaka
Match: dlg2 (disks large homolog 2 [Source:NCBI gene;Acc:101168565])

HSP 1 Score: 53.1434 bits (126), Expect = 4.053e-7
Identity = 49/164 (29.88%), Postives = 73/164 (44.51%), Query Frame = 1 
Query:  688 DRTSFGEQIT-YIVMILPGSIAQMSG-LKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKV-VHLKKENNRFGLRLIRRV--------QGVFVDFVIPDSAADK-ADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT 1143
            D   FGE    YI  I+PG  A   G LKV D I+RV++  V  +S    V+ ++     V ++ + R     T V + + K     G  +   V          +F+  +I   AA K   L  GD+LL +NN  V   S E A  +LK+++  + L V   T
Sbjct:   59 DNPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRRRRPAPETVVEIKITKGPKGLGFSIAGGVGNQHLPGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPT 222
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Planmine SMEST
Match: SMESG000032390.1 (SMESG000032390.1)

HSP 1 Score: 675.626 bits (1742), Expect = 0.000e+0
Identity = 359/361 (99.45%), Postives = 359/361 (99.45%), Query Frame = 1 
Query:  247 ILDKSMPCSPFKNKVMRXXXXXXXXXXXXXPIKNHRHLSYPIIHTNIQRRVKSVLSLPQKTLNSPTSLKIKPXXXXXXXXXXXXXIHILNSFHKNNHETDDNSASFGSVCNNHNSSETENSISYHPIDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPNSPNRSRYNELKNHC 1329
            I  KSMPCSPFKNKVMRNSSCDRSNSVSNSPIKNHRHLSYPIIHTNIQRRVKSVLSLPQKTLNSPTSLKIKPFSKDKFDNNDSSSIHILNSFHKNNHETDDNSASFGSVCNNHNSSETENSISYHPIDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPNSPNRSRYNELKNHC
Sbjct:   65 ISSKSMPCSPFKNKVMRNSSCDRSNSVSNSPIKNHRHLSYPIIHTNIQRRVKSVLSLPQKTLNSPTSLKIKPFSKDKFDNNDSSSIHILNSFHKNNHETDDNSASFGSVCNNHNSSETENSISYHPIDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDATFAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPNSPNRSRYNELKNHC 425

HSP 2 Score: 123.635 bits (309), Expect = 6.348e-31
Identity = 62/63 (98.41%), Postives = 63/63 (100.00%), Query Frame = 3 
Query:   69 MSAKLSTGYRELNSSLLNITSVSTNNSPLLRRLQITKIKHLLSFKSKISPLTKECVNNHDSGQ 257
            MSAKLSTGYRELNSSLLNITSVSTNNSPLLRRLQITKIKHLLSFKSKISPLTKECVNNHDSG+
Sbjct:    1 MSAKLSTGYRELNSSLLNITSVSTNNSPLLRRLQITKIKHLLSFKSKISPLTKECVNNHDSGK 63
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Planmine SMEST
Match: SMESG000028232.1 (SMESG000028232.1)

HSP 1 Score: 144.821 bits (364), Expect = 2.518e-39
Identity = 76/178 (42.70%), Postives = 120/178 (67.42%), Query Frame = 1 
Query:  568 SVCNNHNSSETENSISYHPIDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLK 1101
            S C++   S  + S +     E RDV+L +DS ++FGIK++R   GE   YI MI+  S A  +GLKVGD+I+RV+N  + + S +TL++ I+  +  V++ +K R ++ R ++V LKK N +FG+R+ RR +G++   V+P+S+A  A +KEGD++LKIN+  VSHWSQE+ T LL+
Sbjct:  114 SCCSSPYKSNLDISTTSLHYQETRDVILTKDSFEKFGIKINR--IGESF-YISMIVCDSPAAKAGLKVGDEIIRVNNQTIDRYSNKTLIELIKNNEREVKISFKPRLVIARLRLVILKKVNGKFGIRIQRRSEGIYFAAVLPNSSACLAGIKEGDEILKINDEIVSHWSQEEVTRLLR 288
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Planmine SMEST
Match: SMESG000028232.1 (SMESG000028232.1)

HSP 1 Score: 144.821 bits (364), Expect = 2.680e-39
Identity = 76/178 (42.70%), Postives = 120/178 (67.42%), Query Frame = 1 
Query:  568 SVCNNHNSSETENSISYHPIDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLK 1101
            S C++   S  + S +     E RDV+L +DS ++FGIK++R   GE   YI MI+  S A  +GLKVGD+I+RV+N  + + S +TL++ I+  +  V++ +K R ++ R ++V LKK N +FG+R+ RR +G++   V+P+S+A  A +KEGD++LKIN+  VSHWSQE+ T LL+
Sbjct:  108 SCCSSPYKSNLDISTTSLHYQETRDVILTKDSFEKFGIKINR--IGESF-YISMIVCDSPAAKAGLKVGDEIIRVNNQTIDRYSNKTLIELIKNNEREVKISFKPRLVIARLRLVILKKVNGKFGIRIQRRSEGIYFAAVLPNSSACLAGIKEGDEILKINDEIVSHWSQEEVTRLLR 282
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BLAST of PDZ/DHR/GLGF domain protein vs. Planmine SMEST
Match: SMESG000028750.1 (SMESG000028750.1)

HSP 1 Score: 136.346 bits (342), Expect = 1.748e-35
Identity = 64/161 (39.75%), Postives = 109/161 (67.70%), Query Frame = 1 
Query:  622 PIDEIRDVVLVRDSSKRFGIKLDRTSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIPDSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKN 1104
            P  EIR++ L+++ S+++G K+++   G    +I  +LP S    +GLKVGD+IVR++N  + ++S   L++ I++ +  ++V +K R +++R + V ++K + R G+RL ++ +G+F+  VI DS A +A LKEGD+LLKINN  VS WSQEK T  L++
Sbjct:  201 PFQEIREICLIKEKSEKYGFKVEKIGMG---IFITNLLPDSPTVKAGLKVGDEIVRLNNLQISELSNVELIEQIKSSETCLKVSFKPRLVVMRLRDVIIRKVDGRLGIRLQKKPEGLFLAIVITDSPASRAGLKEGDELLKINNEIVSDWSQEKVTQYLRD 358
[Close]
BLAST of PDZ/DHR/GLGF domain protein vs. Planmine SMEST
Match: SMESG000061485.1 (SMESG000061485.1)

HSP 1 Score: 58.9214 bits (141), Expect = 5.040e-9
Identity = 42/149 (28.19%), Postives = 79/149 (53.02%), Query Frame = 1 
Query:  727 MILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYIRAKKDSVRVFYKARSLLVRT-----------KVVHLKKENNRFGLRLIRRV--QGVFVDFVIPDSAA-DKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHV 1131
            + L G I+Q   L+ GDQI+ V+NF +      T   ++ AK+    +  K R ++ R             V  +K+ +++ G+ L ++   +G+++  +IP S A    DL +GD++L INN+++ + SQE A  ++K + + + L V
Sbjct:  345 IYLDGIISQDCRLRPGDQILEVNNFDL------TNATHVEAKRALSMLSSKCRFVIFRECAPVSNKLEIFTVTLVKRHDSQLGIVLDKKRNHEGIYIRNIIPGSEAYMNGDLAKGDRILSINNIEIGNGSQEYAAKIIKEALENVILVV 487
The following BLAST results are available for this feature:
BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PDZD33.855e-1126.98PDZ domain containing 3 [Source:HGNC Symbol;Acc:HG... [more]
PDZD33.939e-1127.05PDZ domain containing 3 [Source:HGNC Symbol;Acc:HG... [more]
PDZD37.015e-1126.98PDZ domain containing 3 [Source:HGNC Symbol;Acc:HG... [more]
DLG26.144e-928.76discs large MAGUK scaffold protein 2 [Source:HGNC ... [more]
DLG21.473e-828.76discs large MAGUK scaffold protein 2 [Source:HGNC ... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mpz-15.884e-627.74Multiple PDZ domain protein [Source:UniProtKB/TrE... [more]
mpz-16.329e-627.74Multiple PDZ domain protein [Source:UniProtKB/TrE... [more]
mpz-16.622e-627.74Multiple PDZ domain protein [Source:UniProtKB/TrE... [more]
mpz-16.800e-627.74Multiple PDZ domain protein [Source:UniProtKB/TrE... [more]
mpz-17.049e-627.74Multiple PDZ domain protein [Source:UniProtKB/TrE... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dlg14.617e-743.64gene:FBgn0001624 transcript:FBtr0112812[more]
dlg14.864e-733.77gene:FBgn0001624 transcript:FBtr0073489[more]
dlg14.864e-733.77gene:FBgn0001624 transcript:FBtr0308089[more]
dlg14.866e-743.64gene:FBgn0001624 transcript:FBtr0333262[more]
dlg14.898e-733.77gene:FBgn0001624 transcript:FBtr0073486[more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dlg21.001e-826.51discs, large homolog 2 (Drosophila) [Source:NCBI g... [more]
dlg4b4.270e-841.82pep chromosome:GRCz11:23:44307996:44332790:1 gene:... [more]
sdcbp2.598e-740.51syndecan binding protein (syntenin) [Source:ZFIN;A... [more]
pdzd3a6.854e-725.63PDZ domain containing 3a [Source:ZFIN;Acc:ZDB-GENE... [more]
pdzd112.387e-641.18PDZ domain containing 11 [Source:NCBI gene;Acc:405... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hjv4.430e-828.76hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB... [more]
hjv4.690e-825.87hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB... [more]
hjv5.545e-828.76hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB... [more]
hjv5.968e-828.76hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB... [more]
hjv6.145e-825.58hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pdzd33.673e-926.49PDZ domain containing 3 [Source:MGI Symbol;Acc:MGI... [more]
Dlg24.258e-828.76discs large MAGUK scaffold protein 2 [Source:MGI S... [more]
Dlg24.427e-828.76discs large MAGUK scaffold protein 2 [Source:MGI S... [more]
Dlg25.102e-828.76discs large MAGUK scaffold protein 2 [Source:MGI S... [more]
Dlg25.350e-828.76discs large MAGUK scaffold protein 2 [Source:MGI S... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q86UT5|NHRF4_HUMAN1.851e-1026.98Na(+)/H(+) exchange regulatory cofactor NHE-RF4 OS... [more]
sp|Q99MJ6|NHRF4_MOUSE2.615e-826.49Na(+)/H(+) exchange regulatory cofactor NHE-RF4 OS... [more]
sp|Q6R005|DLG4_DANRE6.240e-824.49Disks large homolog 4 OS=Danio rerio OX=7955 GN=dl... [more]
sp|Q5PYH7|DLG2_DANRE6.913e-826.51Disks large homolog 2 OS=Danio rerio OX=7955 GN=dl... [more]
sp|Q15700|DLG2_HUMAN1.938e-728.76Disks large homolog 2 OS=Homo sapiens OX=9606 GN=D... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0RLE51.288e-3033.64Uncharacterized protein OS=Fasciola hepatica OX=61... [more]
A0A5K4FF091.361e-3037.89Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
A0A4Z2DF978.790e-3037.27Protein scribble OS=Schistosoma japonicum OX=6182 ... [more]
A0A183AN871.107e-2640.13Uncharacterized protein OS=Echinostoma caproni OX=... [more]
G7YEW71.299e-2637.04Syntenin-2 OS=Clonorchis sinensis OX=79923 GN=CLF_... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dlg21.540e-926.98discs, large homolog 2 (Drosophila) [Source:NCBI g... [more]
dlg21.866e-926.98discs, large homolog 2 (Drosophila) [Source:NCBI g... [more]
dlg22.122e-926.98discs, large homolog 2 (Drosophila) [Source:NCBI g... [more]
dlg22.195e-926.98discs, large homolog 2 (Drosophila) [Source:NCBI g... [more]
dlg25.239e-926.98discs, large homolog 2 (Drosophila) [Source:NCBI g... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
SDCBP7.587e-834.15syndecan binding protein [Source:HGNC Symbol;Acc:H... [more]
ENSPMAT00000004677.19.794e-829.37pep scaffold:Pmarinus_7.0:GL479538:28591:32639:-1 ... [more]
lin7a1.710e-634.62lin-7 homolog A (C. elegans) [Source:ZFIN;Acc:ZDB-... [more]
ENSPMAT00000001894.19.681e-624.87pep scaffold:Pmarinus_7.0:GL482309:11063:22203:-1 ... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO420951.458e-633.70Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO483724.668e-629.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
dlg22.875e-729.88disks large homolog 2 [Source:NCBI gene;Acc:101168... [more]
dlg23.062e-729.88disks large homolog 2 [Source:NCBI gene;Acc:101168... [more]
dlg23.548e-729.88disks large homolog 2 [Source:NCBI gene;Acc:101168... [more]
grid2ipa3.786e-740.51delphilin [Source:NCBI gene;Acc:101160910][more]
dlg24.053e-729.88disks large homolog 2 [Source:NCBI gene;Acc:101168... [more]
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BLAST of PDZ/DHR/GLGF domain protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000032390.16.348e-3199.45SMESG000032390.1[more]
SMESG000028232.12.518e-3942.70SMESG000028232.1[more]
SMESG000028232.12.680e-3942.70SMESG000028232.1[more]
SMESG000028750.11.748e-3539.75SMESG000028750.1[more]
SMESG000061485.15.040e-928.19SMESG000061485.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30015740 ID=SMED30015740|Name=PDZ/DHR/GLGF domain protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1336bp
GAAATATAAATGATAATAATAACGCGTCTCCGGCCTTTACATTATTCATA
TGTAAAATCCCTCTCCATATGAGTGCAAAACTCTCCACAGGTTATCGGGA
ATTAAATAGTTCTCTTCTGAACATTACGTCTGTGTCTACGAATAATTCTC
CTTTGTTAAGGCGATTACAAATAACCAAAATCAAACATCTTTTATCATTC
AAAAGTAAAATCTCTCCATTGACGAAGGAGTGCGTCAACAATCATGATTC
TGGACAAATCAATGCCATGTTCTCCATTCAAAAATAAAGTAATGAGAAAT
TCTTCATGCGACCGAAGCAACTCAGTTTCTAACAGTCCGATTAAAAATCA
TAGGCACCTTTCATATCCTATAATTCATACAAATATCCAAAGAAGAGTAA
AATCAGTATTGAGTTTACCCCAGAAGACATTGAATTCCCCAACCTCCTTG
AAAATCAAACCATTTTCAAAAGATAAATTCGACAATAACGATTCATCTTC
AATACACATTTTAAATTCATTTCATAAAAACAATCACGAAACCGACGACA
ACTCTGCTTCTTTTGGTTCGGTATGCAACAATCACAATTCTTCAGAAACA
GAAAATTCGATCTCCTACCATCCGATTGATGAAATAAGAGACGTAGTTCT
AGTGAGAGACTCTAGCAAGAGGTTCGGCATTAAATTAGATCGAACTTCAT
TTGGTGAACAGATCACATATATTGTGATGATTTTACCGGGATCTATTGCT
CAAATGTCTGGATTGAAAGTCGGGGATCAAATTGTCCGAGTTGATAATTT
CTATGTCCATCAGATCAGTATGGAGACTCTTGTCGATTACATCAGAGCGA
AAAAAGATTCTGTTCGAGTATTTTACAAGGCTCGCTCATTGCTGGTCAGA
ACAAAAGTTGTTCATTTAAAAAAGGAAAACAACAGATTTGGCCTTCGTTT
AATCAGACGAGTTCAAGGGGTATTTGTTGATTTTGTCATCCCGGATTCAG
CTGCTGACAAAGCTGATCTTAAAGAAGGAGATCAACTGCTCAAAATCAAC
AACGTCGATGTTTCACATTGGTCCCAAGAAAAGGCTACTCACCTGCTCAA
AAATTCAACACAAACTCTGACATTGCACGTCTACGATGCCACATTTGCTG
CCAATGATTGTTTAAATCAAAAAAGCATATTTTGTGACTGCAATATATCA
AATGTGCTGTCTTCTTCAGTCAATACAGAATTCGAAAAATCAGTATCATC
AAAAGTCCATTGTGAATTCACAAAATCTCTTCCGAATAGTCCTAACAGAT
CCCGATACAATGAATTGAAAAATCACTGCTAATCAT
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protein sequence of SMED30015740-orf-1

>SMED30015740-orf-1 ID=SMED30015740-orf-1|Name=SMED30015740-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=363bp
MILDKSMPCSPFKNKVMRNSSCDRSNSVSNSPIKNHRHLSYPIIHTNIQR
RVKSVLSLPQKTLNSPTSLKIKPFSKDKFDNNDSSSIHILNSFHKNNHET
DDNSASFGSVCNNHNSSETENSISYHPIDEIRDVVLVRDSSKRFGIKLDR
TSFGEQITYIVMILPGSIAQMSGLKVGDQIVRVDNFYVHQISMETLVDYI
RAKKDSVRVFYKARSLLVRTKVVHLKKENNRFGLRLIRRVQGVFVDFVIP
DSAADKADLKEGDQLLKINNVDVSHWSQEKATHLLKNSTQTLTLHVYDAT
FAANDCLNQKSIFCDCNISNVLSSSVNTEFEKSVSSKVHCEFTKSLPNSP
NRSRYNELKNHC*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR036034PDZ_sf
IPR001478PDZ
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0030251guanylate cyclase inhibitor activity
GO:0008022protein C-terminus binding
GO:0008200ion channel inhibitor activity
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0035003subapical complex
GO:0045177apical part of cell
GO:0005737cytoplasm
GO:0005829cytosol
GO:0005886plasma membrane
GO:0005903brush border
Vocabulary: biological process
TermDefinition
GO:0019934cGMP-mediated signaling
GO:0030827negative regulation of cGMP biosynthetic process
GO:0031283negative regulation of guanylate cyclase activity
GO:0065009regulation of molecular function
GO:0006811ion transport
GO:0006833water transport
GO:0007168receptor guanylyl cyclase signaling pathway
GO:0009636response to toxic substance
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001478PDZ domainSMARTSM00228pdz_newcoord: 230..300
e-value: 1.2E-15
score: 67.9
coord: 142..215
e-value: 3.8E-4
score: 29.8
IPR001478PDZ domainPFAMPF00595PDZcoord: 134..209
e-value: 1.5E-8
score: 34.9
coord: 223..296
e-value: 8.0E-15
score: 55.0
IPR001478PDZ domainPROSITEPS50106PDZcoord: 133..215
score: 12.325
IPR001478PDZ domainPROSITEPS50106PDZcoord: 222..300
score: 15.963
IPR036034PDZ superfamilyGENE3DG3DSA:2.30.42.10coord: 213..310
e-value: 6.6E-21
score: 76.2
IPR036034PDZ superfamilyGENE3DG3DSA:2.30.42.10coord: 122..212
e-value: 1.3E-13
score: 52.8
IPR036034PDZ superfamilySUPERFAMILYSSF50156PDZ domain-likecoord: 219..296
IPR036034PDZ superfamilySUPERFAMILYSSF50156PDZ domain-likecoord: 124..209
NoneNo IPR availablePANTHERPTHR14191:SF3GH04176Pcoord: 94..208
NoneNo IPR availablePANTHERPTHR14191PDZ DOMAIN CONTAINING PROTEINcoord: 94..208
NoneNo IPR availablePANTHERPTHR14191PDZ DOMAIN CONTAINING PROTEINcoord: 219..300
NoneNo IPR availablePANTHERPTHR14191:SF3GH04176Pcoord: 219..300
NoneNo IPR availableCDDcd00992PDZ_signalingcoord: 220..296
e-value: 1.67539E-18
score: 77.2218
NoneNo IPR availableCDDcd00992PDZ_signalingcoord: 131..209
e-value: 4.31959E-14
score: 64.8954